RPL7P45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.46195069
2DNA deamination (GO:0045006)4.41688191
3piRNA metabolic process (GO:0034587)4.35911104
4viral transcription (GO:0019083)4.27362001
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.12344972
6protein neddylation (GO:0045116)4.09074339
7translational termination (GO:0006415)4.05621805
8ATP synthesis coupled proton transport (GO:0015986)4.01778357
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01778357
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00665874
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98869749
12tryptophan metabolic process (GO:0006568)3.98657993
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.98121928
14ribosomal large subunit biogenesis (GO:0042273)3.89905032
15cotranslational protein targeting to membrane (GO:0006613)3.89807207
16protein targeting to ER (GO:0045047)3.87317723
17positive regulation of granulocyte differentiation (GO:0030854)3.83177765
18GTP biosynthetic process (GO:0006183)3.81427021
19kynurenine metabolic process (GO:0070189)3.77062307
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.76181559
21regulation of mitotic spindle checkpoint (GO:1903504)3.76181559
22protein localization to endoplasmic reticulum (GO:0070972)3.65965161
23T-helper cell differentiation (GO:0042093)3.61296615
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.61296615
25ribonucleoprotein complex disassembly (GO:0032988)3.60239724
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.59703960
27indolalkylamine metabolic process (GO:0006586)3.53530335
28tryptophan catabolic process (GO:0006569)3.53354329
29indole-containing compound catabolic process (GO:0042436)3.53354329
30indolalkylamine catabolic process (GO:0046218)3.53354329
31translational elongation (GO:0006414)3.50475165
32spliceosomal complex assembly (GO:0000245)3.49167370
33aldehyde catabolic process (GO:0046185)3.49053622
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47592145
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.47592145
36NADH dehydrogenase complex assembly (GO:0010257)3.47592145
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.43292241
38alpha-beta T cell differentiation involved in immune response (GO:0002293)3.39320114
39alpha-beta T cell activation involved in immune response (GO:0002287)3.39320114
40T cell differentiation involved in immune response (GO:0002292)3.39320114
41proteasome assembly (GO:0043248)3.34810608
42regulation of isotype switching to IgG isotypes (GO:0048302)3.29906005
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29771846
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29771846
45DNA methylation involved in gamete generation (GO:0043046)3.26511937
46regulation of cellular respiration (GO:0043457)3.24545456
47termination of RNA polymerase III transcription (GO:0006386)3.24255367
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.24255367
49regulation of granulocyte differentiation (GO:0030852)3.24222367
50regulation of chronic inflammatory response (GO:0002676)3.22716369
51regulation of oxidative phosphorylation (GO:0002082)3.18998193
52organelle disassembly (GO:1903008)3.17330443
53regulation of immunoglobulin secretion (GO:0051023)3.16422808
54translational initiation (GO:0006413)3.16373945
55electron transport chain (GO:0022900)3.15521935
56UTP biosynthetic process (GO:0006228)3.13958377
57respiratory electron transport chain (GO:0022904)3.13358370
58protein complex biogenesis (GO:0070271)3.12897548
59negative regulation of T-helper cell differentiation (GO:0045623)3.10680629
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10680629
61auditory receptor cell stereocilium organization (GO:0060088)3.08522771
62ribosomal small subunit biogenesis (GO:0042274)3.04974177
63translation (GO:0006412)3.04188447
64UTP metabolic process (GO:0046051)2.97856048
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95176062
66mitochondrial respiratory chain complex assembly (GO:0033108)2.93916104
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92324650
68regulation of beta-amyloid formation (GO:1902003)2.90734075
69positive regulation of defense response to virus by host (GO:0002230)2.90118300
70negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89803574
71cellular protein complex disassembly (GO:0043624)2.87153227
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86876271
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82200967
74positive regulation of activated T cell proliferation (GO:0042104)2.79072816
75water-soluble vitamin biosynthetic process (GO:0042364)2.78903618
76negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.78363601
77positive regulation of organelle assembly (GO:1902117)2.75249753
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.74738640
79behavioral response to nicotine (GO:0035095)2.73130338
80viral life cycle (GO:0019058)2.72599145
81rRNA modification (GO:0000154)2.71615556
82negative regulation of macrophage differentiation (GO:0045650)2.70856483
83cellular ketone body metabolic process (GO:0046950)2.70596137
84peptidyl-histidine modification (GO:0018202)2.69367571
85CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69105955
86termination of RNA polymerase I transcription (GO:0006363)2.68968741
87negative regulation of acute inflammatory response (GO:0002674)2.65177060
88regulation of cilium movement (GO:0003352)2.62199100
89indole-containing compound metabolic process (GO:0042430)2.61842511
90regulation of action potential (GO:0098900)2.61189863
91maturation of SSU-rRNA (GO:0030490)2.60173902
92multicellular organism reproduction (GO:0032504)2.58457187
93positive regulation of isotype switching (GO:0045830)2.58355491
94phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57808564
95lateral ventricle development (GO:0021670)2.56352891
96positive regulation of immunoglobulin production (GO:0002639)2.55236365
97innate immune response in mucosa (GO:0002227)2.54838946
98positive regulation of DNA recombination (GO:0045911)2.53715112
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50628488
100nephron tubule morphogenesis (GO:0072078)2.50397744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48848867
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.58937257
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45754076
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36535920
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.24837617
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.02077914
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94782882
8IRF1_19129219_ChIP-ChIP_H3396_Human2.63769468
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61625153
10IGF1R_20145208_ChIP-Seq_DFB_Human2.59130385
11EZH2_22144423_ChIP-Seq_EOC_Human2.51089806
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36182793
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34420493
14ELK1_19687146_ChIP-ChIP_HELA_Human2.26916285
15ZNF274_21170338_ChIP-Seq_K562_Hela2.26397121
16VDR_22108803_ChIP-Seq_LS180_Human2.26028651
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.19472913
18VDR_23849224_ChIP-Seq_CD4+_Human2.16527315
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.09082905
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01152710
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95204908
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88015389
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87780646
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83237191
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82344721
26ER_23166858_ChIP-Seq_MCF-7_Human1.69116972
27FOXP3_21729870_ChIP-Seq_TREG_Human1.68932936
28EWS_26573619_Chip-Seq_HEK293_Human1.67808951
29GATA3_26560356_Chip-Seq_TH2_Human1.60349928
30TP53_22573176_ChIP-Seq_HFKS_Human1.57425181
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55030203
32FUS_26573619_Chip-Seq_HEK293_Human1.47850218
33MYC_18940864_ChIP-ChIP_HL60_Human1.47410496
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46108136
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44804158
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44140145
37BCAT_22108803_ChIP-Seq_LS180_Human1.41419261
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38831232
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.38831232
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.38243550
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35834101
42CBP_20019798_ChIP-Seq_JUKART_Human1.34146744
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34146744
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30874934
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30225055
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.28017402
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.27100941
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25551885
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.25537285
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25358724
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.24561893
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23735248
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22473812
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22201709
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.21533576
56SOX2_19829295_ChIP-Seq_ESCs_Human1.19932205
57NANOG_19829295_ChIP-Seq_ESCs_Human1.19932205
58GBX2_23144817_ChIP-Seq_PC3_Human1.18909975
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18875928
60AR_20517297_ChIP-Seq_VCAP_Human1.18759437
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18585422
62P300_19829295_ChIP-Seq_ESCs_Human1.14897291
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11025654
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06739769
65NCOR_22424771_ChIP-Seq_293T_Human1.06240940
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04416729
67* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02783200
68MYC_19829295_ChIP-Seq_ESCs_Human1.01429897
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00623960
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00316414
71E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99872858
72ELK1_22589737_ChIP-Seq_MCF10A_Human0.99534558
73TAF15_26573619_Chip-Seq_HEK293_Human0.96204425
74TTF2_22483619_ChIP-Seq_HELA_Human0.95941187
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95748517
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94479591
77OCT4_18555785_Chip-Seq_ESCs_Mouse0.94151818
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92717241
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.92690271
80MYB_26560356_Chip-Seq_TH2_Human0.92072019
81RAC3_21632823_ChIP-Seq_H3396_Human0.91447668
82IRF8_21731497_ChIP-ChIP_J774_Mouse0.90909172
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90613887
84TCF4_22108803_ChIP-Seq_LS180_Human0.90311508
85RNF2_27304074_Chip-Seq_NSC_Mouse0.90216576
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.89821445
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89603933
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89469644
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89251977
90YY1_21170310_ChIP-Seq_MESCs_Mouse0.89094674
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88992552
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88803748
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88790853
94CTCF_18555785_Chip-Seq_ESCs_Mouse0.88082613
95ERA_21632823_ChIP-Seq_H3396_Human0.87929112
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87623199
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87424700
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87417994
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.87078680
100TAF2_19829295_ChIP-Seq_ESCs_Human0.86115423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.81664738
2MP0001835_abnormal_antigen_presentation3.90574542
3MP0008875_abnormal_xenobiotic_pharmacok3.29857844
4MP0002138_abnormal_hepatobiliary_system3.23247429
5MP0001968_abnormal_touch/_nociception3.14693478
6MP0001873_stomach_inflammation2.90206242
7MP0009379_abnormal_foot_pigmentation2.89283869
8MP0008877_abnormal_DNA_methylation2.74996144
9MP0008872_abnormal_physiological_respon2.61997186
10MP0003195_calcinosis2.59723402
11MP0004145_abnormal_muscle_electrophysio2.54053330
12MP0005646_abnormal_pituitary_gland2.50350370
13MP0000372_irregular_coat_pigmentation2.29228159
14MP0009697_abnormal_copulation2.23878221
15MP0006292_abnormal_olfactory_placode2.23069887
16MP0005671_abnormal_response_to2.17614370
17MP0003646_muscle_fatigue2.17475682
18MP0005645_abnormal_hypothalamus_physiol2.12167054
19MP0005075_abnormal_melanosome_morpholog2.08449976
20MP0006072_abnormal_retinal_apoptosis2.08014442
21MP0001986_abnormal_taste_sensitivity1.89876469
22MP0002736_abnormal_nociception_after1.75721523
23MP0002837_dystrophic_cardiac_calcinosis1.67671337
24MP0002148_abnormal_hypersensitivity_rea1.66535705
25MP0002234_abnormal_pharynx_morphology1.59133132
26MP0001984_abnormal_olfaction1.58841062
27MP0000685_abnormal_immune_system1.49780664
28MP0001790_abnormal_immune_system1.49457680
29MP0005387_immune_system_phenotype1.49457680
30MP0003693_abnormal_embryo_hatching1.46519177
31MP0002876_abnormal_thyroid_physiology1.46228081
32MP0001800_abnormal_humoral_immune1.45659989
33MP0002733_abnormal_thermal_nociception1.43412764
34MP0004142_abnormal_muscle_tone1.35495898
35MP0002102_abnormal_ear_morphology1.34098965
36MP0001905_abnormal_dopamine_level1.33753645
37MP0001440_abnormal_grooming_behavior1.32916623
38MP0005551_abnormal_eye_electrophysiolog1.30738833
39MP0001348_abnormal_lacrimal_gland1.26020117
40MP0001970_abnormal_pain_threshold1.25886534
41MP0003186_abnormal_redox_activity1.24622804
42MP0001293_anophthalmia1.24439675
43MP0001485_abnormal_pinna_reflex1.22688998
44MP0005670_abnormal_white_adipose1.22375551
45MP0001919_abnormal_reproductive_system1.22162899
46MP0005171_absent_coat_pigmentation1.17905524
47MP0001529_abnormal_vocalization1.17790142
48MP0006276_abnormal_autonomic_nervous1.16483613
49MP0004043_abnormal_pH_regulation1.16256559
50MP0002735_abnormal_chemical_nociception1.13047623
51MP0002166_altered_tumor_susceptibility1.12705315
52MP0002822_catalepsy1.12557038
53MP0008058_abnormal_DNA_repair1.11951287
54MP0005084_abnormal_gallbladder_morpholo1.10283121
55MP0010386_abnormal_urinary_bladder1.05082827
56MP0004742_abnormal_vestibular_system1.04975644
57MP0006036_abnormal_mitochondrial_physio1.03492458
58MP0002006_tumorigenesis1.02701603
59MP0009333_abnormal_splenocyte_physiolog1.02483215
60MP0002272_abnormal_nervous_system0.99921790
61MP0004381_abnormal_hair_follicle0.98575498
62MP0002452_abnormal_antigen_presenting0.97839626
63MP0005389_reproductive_system_phenotype0.96005475
64MP0002723_abnormal_immune_serum0.95062649
65MP0000516_abnormal_urinary_system0.93309656
66MP0005367_renal/urinary_system_phenotyp0.93309656
67MP0005253_abnormal_eye_physiology0.92913113
68MP0005000_abnormal_immune_tolerance0.92857641
69MP0009745_abnormal_behavioral_response0.92551633
70MP0002653_abnormal_ependyma_morphology0.92423621
71MP0003045_fibrosis0.91356327
72MP0006082_CNS_inflammation0.90349112
73MP0003880_abnormal_central_pattern0.89208654
74MP0001663_abnormal_digestive_system0.88844261
75MP0008789_abnormal_olfactory_epithelium0.87766723
76MP0003718_maternal_effect0.87141684
77MP0005410_abnormal_fertilization0.84138990
78MP0002009_preneoplasia0.83917787
79MP0003786_premature_aging0.83681413
80MP0005636_abnormal_mineral_homeostasis0.82821888
81MP0002638_abnormal_pupillary_reflex0.81571398
82MP0009764_decreased_sensitivity_to0.80057520
83MP0003763_abnormal_thymus_physiology0.79849382
84MP0001819_abnormal_immune_cell0.79502407
85MP0000631_abnormal_neuroendocrine_gland0.79411364
86MP0008775_abnormal_heart_ventricle0.79034672
87MP0002420_abnormal_adaptive_immunity0.76775616
88MP0000613_abnormal_salivary_gland0.74271991
89MP0005195_abnormal_posterior_eye0.72126263
90MP0002693_abnormal_pancreas_physiology0.69006101
91MP0001845_abnormal_inflammatory_respons0.68394803
92MP0003787_abnormal_imprinting0.68269192
93MP0002160_abnormal_reproductive_system0.67758522
94MP0003866_abnormal_defecation0.67498119
95MP0002163_abnormal_gland_morphology0.64876284
96MP0001765_abnormal_ion_homeostasis0.63685449
97MP0002277_abnormal_respiratory_mucosa0.62525914
98MP0000538_abnormal_urinary_bladder0.61102925
99MP0005377_hearing/vestibular/ear_phenot0.61022298
100MP0003878_abnormal_ear_physiology0.61022298

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.23137061
2Congenital, generalized hypertrichosis (HP:0004540)4.15542333
3Hypothermia (HP:0002045)3.77101667
4Stomatitis (HP:0010280)3.75969782
5Molar tooth sign on MRI (HP:0002419)3.67406278
6Abnormality of midbrain morphology (HP:0002418)3.67406278
7Mitochondrial inheritance (HP:0001427)3.61721910
83-Methylglutaconic aciduria (HP:0003535)3.51542943
9Acute necrotizing encephalopathy (HP:0006965)3.48157974
10Pancreatic fibrosis (HP:0100732)3.45603926
11Lipid accumulation in hepatocytes (HP:0006561)3.34524511
12Increased hepatocellular lipid droplets (HP:0006565)3.32394937
13Increased CSF lactate (HP:0002490)3.28762515
14Nephronophthisis (HP:0000090)3.26627599
15Progressive macrocephaly (HP:0004481)3.26235956
16Acute encephalopathy (HP:0006846)3.12328397
17Abolished electroretinogram (ERG) (HP:0000550)3.09850582
18Hepatocellular necrosis (HP:0001404)3.07308672
19Abnormality of the prostate (HP:0008775)3.07248276
20IgG deficiency (HP:0004315)3.04934389
21Hepatic necrosis (HP:0002605)2.88042653
22Abnormal mitochondria in muscle tissue (HP:0008316)2.87632076
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79989829
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68880691
25Abnormality of alanine metabolism (HP:0010916)2.68880691
26Hyperalaninemia (HP:0003348)2.68880691
27Exertional dyspnea (HP:0002875)2.64198875
28Abnormality of the renal medulla (HP:0100957)2.62798043
29Methylmalonic acidemia (HP:0002912)2.62342680
30Abnormality of cells of the erythroid lineage (HP:0012130)2.61944398
31Congenital stationary night blindness (HP:0007642)2.60650943
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58854577
33Hypoproteinemia (HP:0003075)2.56021453
34Thyroiditis (HP:0100646)2.52565194
35Renal Fanconi syndrome (HP:0001994)2.51187706
36Posterior subcapsular cataract (HP:0007787)2.45287960
37Abnormal rod and cone electroretinograms (HP:0008323)2.43708155
38Severe combined immunodeficiency (HP:0004430)2.41252714
39Absent thumb (HP:0009777)2.40900959
40Colon cancer (HP:0003003)2.39377828
41Bile duct proliferation (HP:0001408)2.36422019
42Abnormal biliary tract physiology (HP:0012439)2.36422019
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.34002973
44Increased intramyocellular lipid droplets (HP:0012240)2.33552840
45Medial flaring of the eyebrow (HP:0010747)2.32300208
46Fibular aplasia (HP:0002990)2.29617177
47Delayed CNS myelination (HP:0002188)2.27189679
48Pendular nystagmus (HP:0012043)2.24576805
49True hermaphroditism (HP:0010459)2.23321853
50Abnormality of the renal cortex (HP:0011035)2.23258898
51Keratoconus (HP:0000563)2.23170199
52Increased corneal curvature (HP:0100692)2.23170199
53Optic disc pallor (HP:0000543)2.23165438
54Abnormality of B cell number (HP:0010975)2.22455723
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21803453
56Polydipsia (HP:0001959)2.21166142
57Abnormal drinking behavior (HP:0030082)2.21166142
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20183800
59Multiple enchondromatosis (HP:0005701)2.17813358
60Asplenia (HP:0001746)2.17506643
61Rectal fistula (HP:0100590)2.17366252
62Rectovaginal fistula (HP:0000143)2.17366252
63B lymphocytopenia (HP:0010976)2.16586021
64Abnormal number of erythroid precursors (HP:0012131)2.15680024
65Type 2 muscle fiber atrophy (HP:0003554)2.11924258
66Increased serum lactate (HP:0002151)2.11480249
67Methylmalonic aciduria (HP:0012120)2.09640742
68Gaze-evoked nystagmus (HP:0000640)2.08447995
69Increased muscle lipid content (HP:0009058)2.04055187
70Panhypogammaglobulinemia (HP:0003139)2.03621156
71Increased IgM level (HP:0003496)2.03540504
72Tubular atrophy (HP:0000092)1.99624841
73Prostate neoplasm (HP:0100787)1.99540160
74Lactic acidosis (HP:0003128)1.98539081
75Cystic liver disease (HP:0006706)1.97783254
76Cerebral edema (HP:0002181)1.97544053
77Hypochromic microcytic anemia (HP:0004840)1.95989145
78Abnormality of male internal genitalia (HP:0000022)1.94875603
79Aplasia/Hypoplasia of the ulna (HP:0006495)1.94819604
80Attenuation of retinal blood vessels (HP:0007843)1.93227669
81Median cleft lip (HP:0000161)1.92636004
82Alveolar cell carcinoma (HP:0006519)1.92164765
83Woolly hair (HP:0002224)1.91677564
84Respiratory difficulties (HP:0002880)1.90767563
85Abnormality of renal resorption (HP:0011038)1.88504368
86Type II lissencephaly (HP:0007260)1.87444774
87Supernumerary spleens (HP:0009799)1.87207093
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86002156
89Dicarboxylic aciduria (HP:0003215)1.86002156
90Stenosis of the external auditory canal (HP:0000402)1.84963590
91Renal cortical cysts (HP:0000803)1.81183503
92Elevated erythrocyte sedimentation rate (HP:0003565)1.80898198
93Hypoplasia of the ulna (HP:0003022)1.80546165
94Aplasia/hypoplasia of the uterus (HP:0008684)1.79811176
95Cleft eyelid (HP:0000625)1.75712353
96Aplastic anemia (HP:0001915)1.75206244
97Combined immunodeficiency (HP:0005387)1.74405712
98Abnormality of urine glucose concentration (HP:0011016)1.74067207
99Glycosuria (HP:0003076)1.74067207
100Lethargy (HP:0001254)1.73145366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.49012416
2BMPR1B3.40325183
3TLK13.09059129
4NUAK12.89220903
5CDK82.88426978
6TAOK32.57964784
7VRK22.48792990
8SRPK12.47117996
9ZAK2.42218453
10ADRBK22.39905625
11SCYL22.30353645
12TEC2.29899180
13WNK42.25270466
14TXK2.21021130
15BMPR22.06475499
16VRK11.83386766
17GRK11.80374967
18STK391.71748431
19MKNK11.66334031
20TNK21.65281233
21CDK191.63783357
22ITK1.55817968
23FLT31.51601271
24TGFBR11.49088373
25PBK1.47479389
26KIT1.45093886
27CAMKK21.39939238
28ACVR1B1.39508579
29MAP4K21.35127256
30RPS6KA51.29384734
31MST41.25504706
32PIK3CG1.24622570
33RIPK41.20917623
34PHKG21.19050763
35PHKG11.19050763
36OXSR11.14728591
37BCKDK1.14156632
38WNK11.14151044
39CSF1R1.11003071
40SYK1.09015442
41MKNK21.05859491
42DYRK21.04688512
43PDK20.98064316
44MAPKAPK50.96578575
45LIMK10.95573928
46FGFR20.90638600
47PINK10.89802903
48CSNK1G30.88619673
49TAF10.85231031
50BTK0.84238798
51NME20.79049473
52DAPK30.76821933
53CSNK1G10.75235642
54CAMK10.69869321
55CSNK1G20.69698060
56PRKCQ0.69583308
57EIF2AK20.68579983
58DAPK10.66867513
59LYN0.65493546
60STK38L0.65410759
61TRIM280.64933961
62CHEK20.64564777
63MYLK0.64267104
64CSNK1A1L0.64246171
65MAPK130.64180490
66ADRBK10.63236366
67PLK30.63204005
68RPS6KA40.62903085
69IKBKB0.62758437
70TSSK60.61625896
71PRKCE0.59468185
72TIE10.59202401
73INSRR0.58521607
74NLK0.58507700
75CDK90.54715040
76LCK0.54089682
77EIF2AK30.54046177
78ERBB30.51840260
79WNK30.48841045
80CDK30.48616127
81OBSCN0.45911081
82STK160.45869333
83NME10.45820616
84PKN10.44782326
85FES0.44560609
86CDK70.44297698
87MAP4K10.43411255
88PRKCG0.43069560
89NEK10.42049079
90BLK0.41718717
91CAMK2A0.38143575
92SIK20.38053682
93CAMK40.37944859
94ABL20.37906149
95MAP3K120.35678840
96PRKACA0.34264649
97PLK40.31877656
98CSNK1A10.31727009
99ILK0.31659300
100ABL10.30336660

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.09163042
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.91894474
3Allograft rejection_Homo sapiens_hsa053303.88507892
4Autoimmune thyroid disease_Homo sapiens_hsa053203.77239106
5Ribosome_Homo sapiens_hsa030103.55584363
6Protein export_Homo sapiens_hsa030603.10476542
7Oxidative phosphorylation_Homo sapiens_hsa001902.99313797
8RNA polymerase_Homo sapiens_hsa030202.77709476
9Parkinsons disease_Homo sapiens_hsa050122.36371305
10Graft-versus-host disease_Homo sapiens_hsa053322.33458407
11Type I diabetes mellitus_Homo sapiens_hsa049402.12830577
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04653433
13Proteasome_Homo sapiens_hsa030501.98299841
14Primary immunodeficiency_Homo sapiens_hsa053401.69769976
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61443346
16Systemic lupus erythematosus_Homo sapiens_hsa053221.57154604
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56116050
18Alzheimers disease_Homo sapiens_hsa050101.53713066
19Linoleic acid metabolism_Homo sapiens_hsa005911.53279934
20Homologous recombination_Homo sapiens_hsa034401.50962113
21Phototransduction_Homo sapiens_hsa047441.45911007
22Huntingtons disease_Homo sapiens_hsa050161.44210725
23RNA degradation_Homo sapiens_hsa030181.38983478
24Hematopoietic cell lineage_Homo sapiens_hsa046401.36367357
25Rheumatoid arthritis_Homo sapiens_hsa053231.33654344
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30899168
27One carbon pool by folate_Homo sapiens_hsa006701.25612170
28Caffeine metabolism_Homo sapiens_hsa002321.24642530
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22273971
30Antigen processing and presentation_Homo sapiens_hsa046121.21637952
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17755513
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17262521
33Viral myocarditis_Homo sapiens_hsa054161.16226085
34Fanconi anemia pathway_Homo sapiens_hsa034601.13608437
35Staphylococcus aureus infection_Homo sapiens_hsa051501.12674449
36Cardiac muscle contraction_Homo sapiens_hsa042601.09517480
37Nucleotide excision repair_Homo sapiens_hsa034201.00666216
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98637901
39Propanoate metabolism_Homo sapiens_hsa006400.98122974
40Arachidonic acid metabolism_Homo sapiens_hsa005900.97324947
41Pyrimidine metabolism_Homo sapiens_hsa002400.96503877
42Purine metabolism_Homo sapiens_hsa002300.93775058
43Tryptophan metabolism_Homo sapiens_hsa003800.90520558
44Mismatch repair_Homo sapiens_hsa034300.90134376
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85203637
46Collecting duct acid secretion_Homo sapiens_hsa049660.85094125
47Basal transcription factors_Homo sapiens_hsa030220.84096953
48Nitrogen metabolism_Homo sapiens_hsa009100.80213974
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78664095
50RNA transport_Homo sapiens_hsa030130.72763182
51Butanoate metabolism_Homo sapiens_hsa006500.70745665
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70268072
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70091848
54Ether lipid metabolism_Homo sapiens_hsa005650.69770389
55Non-homologous end-joining_Homo sapiens_hsa034500.67299415
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.66705735
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.63569845
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.62572613
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62416218
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60270038
61Leishmaniasis_Homo sapiens_hsa051400.59714193
62Chemical carcinogenesis_Homo sapiens_hsa052040.59363945
63DNA replication_Homo sapiens_hsa030300.59343196
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57627608
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.56792102
66Spliceosome_Homo sapiens_hsa030400.55167241
67ABC transporters_Homo sapiens_hsa020100.55134770
68Peroxisome_Homo sapiens_hsa041460.54919556
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53968953
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51603313
71Olfactory transduction_Homo sapiens_hsa047400.51100540
72Salivary secretion_Homo sapiens_hsa049700.50573382
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49627480
74T cell receptor signaling pathway_Homo sapiens_hsa046600.48643661
75Base excision repair_Homo sapiens_hsa034100.47848413
76Taste transduction_Homo sapiens_hsa047420.45704270
77Retinol metabolism_Homo sapiens_hsa008300.42702085
78Regulation of autophagy_Homo sapiens_hsa041400.42178667
79Metabolic pathways_Homo sapiens_hsa011000.42136735
80Ovarian steroidogenesis_Homo sapiens_hsa049130.42075632
81Alcoholism_Homo sapiens_hsa050340.40337003
82Fatty acid biosynthesis_Homo sapiens_hsa000610.37573509
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36994737
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36274291
85Vitamin B6 metabolism_Homo sapiens_hsa007500.32844987
86Morphine addiction_Homo sapiens_hsa050320.31485143
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31182117
88Dorso-ventral axis formation_Homo sapiens_hsa043200.30455109
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.28549178
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.28064211
91Fat digestion and absorption_Homo sapiens_hsa049750.23944873
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23589404
93Serotonergic synapse_Homo sapiens_hsa047260.21354089
94Steroid biosynthesis_Homo sapiens_hsa001000.19651456
95Sulfur metabolism_Homo sapiens_hsa009200.19555645
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19158964
97Sulfur relay system_Homo sapiens_hsa041220.18003158
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17855079
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17390917
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16073600

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