RPL7P46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)5.57264158
2single strand break repair (GO:0000012)4.99037495
3response to pheromone (GO:0019236)4.70192492
4fatty acid elongation (GO:0030497)4.49354625
5protein polyglutamylation (GO:0018095)4.44090820
6water-soluble vitamin biosynthetic process (GO:0042364)4.34603051
7branched-chain amino acid catabolic process (GO:0009083)4.28004003
8cellular ketone body metabolic process (GO:0046950)4.10339451
9acrosome reaction (GO:0007340)4.04554963
10respiratory chain complex IV assembly (GO:0008535)3.93530623
11folic acid-containing compound biosynthetic process (GO:0009396)3.77283390
12DNA deamination (GO:0045006)3.70037406
13sperm motility (GO:0030317)3.66624522
14protein complex biogenesis (GO:0070271)3.62186375
15ketone body metabolic process (GO:1902224)3.59616246
16C4-dicarboxylate transport (GO:0015740)3.52825404
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.47092069
18NADH dehydrogenase complex assembly (GO:0010257)3.47092069
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47092069
20cullin deneddylation (GO:0010388)3.43698045
21signal peptide processing (GO:0006465)3.43487857
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41058989
23histone H2A acetylation (GO:0043968)3.35554351
24mitochondrial respiratory chain complex assembly (GO:0033108)3.34836196
25protein deneddylation (GO:0000338)3.33258970
26pteridine-containing compound biosynthetic process (GO:0042559)3.28741778
27coenzyme catabolic process (GO:0009109)3.23987916
28rRNA methylation (GO:0031167)3.22613653
29establishment of protein localization to Golgi (GO:0072600)3.21988568
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20990118
31protein targeting to Golgi (GO:0000042)3.20696777
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19934567
33DNA double-strand break processing (GO:0000729)3.19849432
34regulation of microtubule-based movement (GO:0060632)3.18339091
35modulation of growth of symbiont involved in interaction with host (GO:0044144)3.15044614
36regulation of growth of symbiont in host (GO:0044126)3.15044614
37negative regulation of growth of symbiont in host (GO:0044130)3.15044614
38negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.15044614
39branched-chain amino acid metabolic process (GO:0009081)3.13039751
40epithelial cilium movement (GO:0003351)3.11287835
41rRNA modification (GO:0000154)3.08834952
42negative regulation of execution phase of apoptosis (GO:1900118)3.08501664
43positive regulation of respiratory burst (GO:0060267)3.06483591
44preassembly of GPI anchor in ER membrane (GO:0016254)3.06345003
45positive regulation of macrophage activation (GO:0043032)3.06302148
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.05606995
47cytochrome complex assembly (GO:0017004)3.04203048
48DNA damage response, detection of DNA damage (GO:0042769)3.04011777
49IMP biosynthetic process (GO:0006188)2.97140256
50multicellular organism reproduction (GO:0032504)2.97121774
51negative regulation of DNA-dependent DNA replication (GO:2000104)2.96981624
52tetrahydrofolate metabolic process (GO:0046653)2.96750075
53axoneme assembly (GO:0035082)2.94910119
54nonmotile primary cilium assembly (GO:0035058)2.94660484
55negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94189598
56maturation of 5.8S rRNA (GO:0000460)2.93609968
57proline transport (GO:0015824)2.92097598
58cilium morphogenesis (GO:0060271)2.91727202
59non-recombinational repair (GO:0000726)2.85175027
60double-strand break repair via nonhomologous end joining (GO:0006303)2.85175027
61peptidyl-cysteine modification (GO:0018198)2.85028082
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.84085207
63isotype switching (GO:0045190)2.84085207
64somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84085207
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83356344
66adenosine metabolic process (GO:0046085)2.82462928
67alanine transport (GO:0032328)2.81214275
68presynaptic membrane organization (GO:0097090)2.78126767
69negative regulation of DNA recombination (GO:0045910)2.76086555
70regulation of cellular amino acid metabolic process (GO:0006521)2.75381221
71protein localization to Golgi apparatus (GO:0034067)2.72005627
72one-carbon compound transport (GO:0019755)2.70945790
73cellular response to leptin stimulus (GO:0044320)2.70232117
74retrograde transport, vesicle recycling within Golgi (GO:0000301)2.68732059
75sperm-egg recognition (GO:0035036)2.68077734
76microtubule depolymerization (GO:0007019)2.67651323
77tRNA modification (GO:0006400)2.66804040
78regulation of chronic inflammatory response (GO:0002676)2.66661494
79cilium organization (GO:0044782)2.65842137
80spermatid nucleus differentiation (GO:0007289)2.65445194
81opsonization (GO:0008228)2.65343078
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63890067
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63890067
84C-terminal protein lipidation (GO:0006501)2.62613814
85positive regulation of prostaglandin secretion (GO:0032308)2.60312552
86cilium assembly (GO:0042384)2.59925417
87replication fork processing (GO:0031297)2.59842901
88intraciliary transport (GO:0042073)2.58755607
89regulation of protein glycosylation (GO:0060049)2.58313856
90ncRNA catabolic process (GO:0034661)2.57123524
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.57087941
92termination of RNA polymerase III transcription (GO:0006386)2.57087941
93positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.55561531
94C-terminal protein amino acid modification (GO:0018410)2.55209749
95regulation of telomere maintenance (GO:0032204)2.54487603
96intra-Golgi vesicle-mediated transport (GO:0006891)2.54108850
97postsynaptic membrane organization (GO:0001941)2.52604473
98photoreceptor cell maintenance (GO:0045494)2.51041300
99DNA catabolic process, exonucleolytic (GO:0000738)2.49493995
100regulation of cardiac muscle cell contraction (GO:0086004)2.47213125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.42453681
2ZNF274_21170338_ChIP-Seq_K562_Hela3.93216873
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77644832
4IGF1R_20145208_ChIP-Seq_DFB_Human3.17810345
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10094935
6GBX2_23144817_ChIP-Seq_PC3_Human3.06331645
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.88400996
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.46688470
9ELK1_19687146_ChIP-ChIP_HELA_Human2.38856799
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37868498
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37639468
12VDR_22108803_ChIP-Seq_LS180_Human2.30949178
13TAF15_26573619_Chip-Seq_HEK293_Human2.18675302
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14873852
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.03845654
16P300_19829295_ChIP-Seq_ESCs_Human2.00187864
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96017155
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95442135
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90569086
20FUS_26573619_Chip-Seq_HEK293_Human1.90031665
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89921257
22EWS_26573619_Chip-Seq_HEK293_Human1.75631678
23ER_23166858_ChIP-Seq_MCF-7_Human1.72204557
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71771985
25VDR_23849224_ChIP-Seq_CD4+_Human1.71220575
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71202988
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68827692
28CBP_20019798_ChIP-Seq_JUKART_Human1.68827692
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66771753
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59094727
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.56131698
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52146097
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51789342
34KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48183763
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47891123
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47387769
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45197149
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45002228
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.44101345
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39313150
41SMAD4_21799915_ChIP-Seq_A2780_Human1.39058545
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.36033089
43AR_25329375_ChIP-Seq_VCAP_Human1.35744416
44STAT3_23295773_ChIP-Seq_U87_Human1.35647380
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.33722575
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33370211
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31800962
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30550945
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27809044
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.27122418
51TP53_22573176_ChIP-Seq_HFKS_Human1.26896905
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26224382
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23714115
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22712492
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21023883
56TCF4_23295773_ChIP-Seq_U87_Human1.20875056
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.20077419
58NANOG_19829295_ChIP-Seq_ESCs_Human1.18946645
59SOX2_19829295_ChIP-Seq_ESCs_Human1.18946645
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18910125
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18146536
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17723583
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17541184
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.16132011
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15298451
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14765091
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14201372
68IRF1_19129219_ChIP-ChIP_H3396_Human1.14092639
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12109931
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10687693
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10687693
72FOXP3_21729870_ChIP-Seq_TREG_Human1.10567500
73EZH2_22144423_ChIP-Seq_EOC_Human1.10148172
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09155929
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08940120
76TCF4_22108803_ChIP-Seq_LS180_Human1.08341348
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.07439816
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07439816
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.07045366
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.04832107
81MYC_18940864_ChIP-ChIP_HL60_Human1.04418635
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04016033
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03052234
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.02940367
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.02860933
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.02396744
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.01038101
88RUNX2_22187159_ChIP-Seq_PCA_Human1.00781528
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.00132063
90P53_22387025_ChIP-Seq_ESCs_Mouse0.99995465
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99041237
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97466925
93CDX2_22108803_ChIP-Seq_LS180_Human0.97371038
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96849340
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96311147
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95661936
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95259316
98AR_20517297_ChIP-Seq_VCAP_Human0.95092913
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94850379
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94777938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology3.30571505
2MP0002736_abnormal_nociception_after3.10635892
3MP0008058_abnormal_DNA_repair3.05588776
4MP0001984_abnormal_olfaction3.04648343
5MP0003011_delayed_dark_adaptation2.95092004
6MP0005410_abnormal_fertilization2.89926461
7MP0005379_endocrine/exocrine_gland_phen2.80287130
8MP0001968_abnormal_touch/_nociception2.54197369
9MP0002102_abnormal_ear_morphology2.51629868
10MP0008877_abnormal_DNA_methylation2.51535795
11MP0005551_abnormal_eye_electrophysiolog2.40313903
12MP0000372_irregular_coat_pigmentation2.39772535
13MP0003880_abnormal_central_pattern2.36830560
14MP0005253_abnormal_eye_physiology2.27761209
15MP0006072_abnormal_retinal_apoptosis2.18019500
16MP0001529_abnormal_vocalization2.09599007
17MP0009780_abnormal_chondrocyte_physiolo1.89417270
18MP0008875_abnormal_xenobiotic_pharmacok1.89405718
19MP0002254_reproductive_system_inflammat1.84773932
20MP0004043_abnormal_pH_regulation1.79350458
21MP0003718_maternal_effect1.76277483
22MP0001501_abnormal_sleep_pattern1.73826954
23MP0010386_abnormal_urinary_bladder1.61924927
24MP0008789_abnormal_olfactory_epithelium1.61809923
25MP0008872_abnormal_physiological_respon1.51724706
26MP0001905_abnormal_dopamine_level1.43133562
27MP0005670_abnormal_white_adipose1.41492232
28MP0003787_abnormal_imprinting1.40529175
29MP0002837_dystrophic_cardiac_calcinosis1.39887488
30MP0004133_heterotaxia1.37213093
31MP0003122_maternal_imprinting1.35807890
32MP0006054_spinal_hemorrhage1.31847623
33MP0006035_abnormal_mitochondrial_morpho1.29027456
34MP0001486_abnormal_startle_reflex1.28699777
35MP0004215_abnormal_myocardial_fiber1.27999651
36MP0001485_abnormal_pinna_reflex1.27395577
37MP0006276_abnormal_autonomic_nervous1.27023533
38MP0003786_premature_aging1.26968943
39MP0005394_taste/olfaction_phenotype1.23991062
40MP0005499_abnormal_olfactory_system1.23991062
41MP0002928_abnormal_bile_duct1.22595162
42MP0003252_abnormal_bile_duct1.21619246
43MP0002938_white_spotting1.20044675
44MP0001929_abnormal_gametogenesis1.20032572
45MP0003698_abnormal_male_reproductive1.19356398
46MP0006036_abnormal_mitochondrial_physio1.17568254
47MP0009697_abnormal_copulation1.17041309
48MP0003646_muscle_fatigue1.14857190
49MP0005084_abnormal_gallbladder_morpholo1.14705350
50MP0000749_muscle_degeneration1.13278776
51MP0005310_abnormal_salivary_gland1.11030989
52MP0003950_abnormal_plasma_membrane1.08967420
53MP0003186_abnormal_redox_activity1.06471365
54MP0010094_abnormal_chromosome_stability1.04133083
55MP0003878_abnormal_ear_physiology1.01824428
56MP0005377_hearing/vestibular/ear_phenot1.01824428
57MP0002272_abnormal_nervous_system0.99653925
58MP0008775_abnormal_heart_ventricle0.98681218
59MP0005332_abnormal_amino_acid0.98622667
60MP0002734_abnormal_mechanical_nocicepti0.98346546
61MP0009745_abnormal_behavioral_response0.97583853
62MP0001970_abnormal_pain_threshold0.95016569
63MP0005645_abnormal_hypothalamus_physiol0.94571893
64MP0002090_abnormal_vision0.94546238
65MP0002557_abnormal_social/conspecific_i0.88052859
66MP0009764_decreased_sensitivity_to0.87939940
67MP0004484_altered_response_of0.87935903
68MP0001756_abnormal_urination0.86828127
69MP0000685_abnormal_immune_system0.86797924
70MP0001177_atelectasis0.86773452
71MP0000538_abnormal_urinary_bladder0.85873286
72MP0005636_abnormal_mineral_homeostasis0.85461306
73MP0003195_calcinosis0.84442357
74MP0000013_abnormal_adipose_tissue0.83751673
75MP0009046_muscle_twitch0.81372031
76MP0001764_abnormal_homeostasis0.80960176
77MP0001963_abnormal_hearing_physiology0.80797226
78MP0002277_abnormal_respiratory_mucosa0.80096462
79MP0000569_abnormal_digit_pigmentation0.79136588
80MP0000613_abnormal_salivary_gland0.78129664
81MP0005423_abnormal_somatic_nervous0.77617690
82MP0005391_vision/eye_phenotype0.76837638
83MP0001661_extended_life_span0.76093276
84MP0000427_abnormal_hair_cycle0.75814921
85MP0002229_neurodegeneration0.74958834
86MP0005395_other_phenotype0.74705391
87MP0001986_abnormal_taste_sensitivity0.73932495
88MP0005165_increased_susceptibility_to0.73135661
89MP0005195_abnormal_posterior_eye0.72306090
90MP0002233_abnormal_nose_morphology0.72184017
91MP0004084_abnormal_cardiac_muscle0.71950565
92MP0001873_stomach_inflammation0.71694379
93MP0009785_altered_susceptibility_to0.68798120
94MP0004085_abnormal_heartbeat0.67479744
95MP0002733_abnormal_thermal_nociception0.67197627
96MP0002876_abnormal_thyroid_physiology0.66471197
97MP0002210_abnormal_sex_determination0.66461576
98MP0002067_abnormal_sensory_capabilities0.65989575
99MP0001853_heart_inflammation0.65730932
100MP0002572_abnormal_emotion/affect_behav0.65608925

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.94263332
2Methylmalonic acidemia (HP:0002912)3.65439963
3Nephrogenic diabetes insipidus (HP:0009806)3.51213176
4Acute necrotizing encephalopathy (HP:0006965)3.50020492
5Congenital primary aphakia (HP:0007707)3.47926656
6Gait imbalance (HP:0002141)3.46948478
7Methylmalonic aciduria (HP:0012120)3.44055031
8Acute encephalopathy (HP:0006846)3.42726937
9Pancreatic cysts (HP:0001737)3.30158848
10Progressive macrocephaly (HP:0004481)3.25690276
11Chronic hepatic failure (HP:0100626)3.20625498
12True hermaphroditism (HP:0010459)3.20481734
13Pancreatic fibrosis (HP:0100732)3.19748476
14Nephronophthisis (HP:0000090)3.06848219
15Abnormal mitochondria in muscle tissue (HP:0008316)3.01708038
16Increased CSF lactate (HP:0002490)2.96039262
17Mitochondrial inheritance (HP:0001427)2.93956825
18Abnormality of midbrain morphology (HP:0002418)2.83784688
19Molar tooth sign on MRI (HP:0002419)2.83784688
20Pancreatic islet-cell hyperplasia (HP:0004510)2.83383717
21Prominent metopic ridge (HP:0005487)2.83203020
22Lipid accumulation in hepatocytes (HP:0006561)2.82564828
23Large for gestational age (HP:0001520)2.82137711
24Poor coordination (HP:0002370)2.80711698
25Tubulointerstitial nephritis (HP:0001970)2.78578350
26Hyperglycinemia (HP:0002154)2.75791211
27Gaze-evoked nystagmus (HP:0000640)2.75507758
28Hemiparesis (HP:0001269)2.74905017
29Genital tract atresia (HP:0001827)2.69322824
30Abnormality of the metopic suture (HP:0005556)2.66716079
31Vaginal atresia (HP:0000148)2.65958184
32Increased hepatocellular lipid droplets (HP:0006565)2.63278008
33Hepatocellular necrosis (HP:0001404)2.56208692
34Occipital encephalocele (HP:0002085)2.53409226
35Cerebral edema (HP:0002181)2.49170186
36Hepatic necrosis (HP:0002605)2.48558768
37Hypoproteinemia (HP:0003075)2.44611342
38Tubular atrophy (HP:0000092)2.42559690
39Hypoglycemic coma (HP:0001325)2.40153789
40Adactyly (HP:0009776)2.39284538
41Abnormality of glycolysis (HP:0004366)2.37987378
42Abnormality of glycine metabolism (HP:0010895)2.37555148
43Abnormality of serine family amino acid metabolism (HP:0010894)2.37555148
44Progressive cerebellar ataxia (HP:0002073)2.37107019
45Cholecystitis (HP:0001082)2.36520419
46Abnormal gallbladder physiology (HP:0012438)2.36520419
47Abnormality of the renal cortex (HP:0011035)2.35864841
48Volvulus (HP:0002580)2.35037074
49Renal Fanconi syndrome (HP:0001994)2.34885080
50Abnormality of the renal medulla (HP:0100957)2.34546643
51Attenuation of retinal blood vessels (HP:0007843)2.34379925
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.33840351
53Hypoplasia of the thymus (HP:0000778)2.33317782
54Abnormality of vitamin B metabolism (HP:0004340)2.33115613
55Hyperinsulinemic hypoglycemia (HP:0000825)2.27330071
56Bile duct proliferation (HP:0001408)2.26010750
57Abnormal biliary tract physiology (HP:0012439)2.26010750
58Generalized aminoaciduria (HP:0002909)2.24262371
59Pendular nystagmus (HP:0012043)2.23029146
60Intestinal atresia (HP:0011100)2.08474063
61Abnormality of endocrine pancreas physiology (HP:0012093)2.06908182
62Abnormality of the pancreatic islet cells (HP:0006476)2.06908182
63Hypothermia (HP:0002045)2.06468952
64Muscular hypotonia of the trunk (HP:0008936)2.03356997
65Limb hypertonia (HP:0002509)2.03192923
66Late onset (HP:0003584)2.03182046
67Horizontal nystagmus (HP:0000666)2.02643130
68Hyperglycinuria (HP:0003108)2.02112352
69Thyroiditis (HP:0100646)1.99330764
70Anencephaly (HP:0002323)1.98811673
71Optic disc pallor (HP:0000543)1.98045810
72Renal cortical cysts (HP:0000803)1.97537698
73Poor suck (HP:0002033)1.93544841
74Poor head control (HP:0002421)1.92364221
75Hypomagnesemia (HP:0002917)1.91510683
76Increased serum pyruvate (HP:0003542)1.90625903
77Postaxial foot polydactyly (HP:0001830)1.89714691
78Oligodactyly (hands) (HP:0001180)1.89386836
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.89127046
80Supernumerary spleens (HP:0009799)1.88265159
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87827912
82Dicarboxylic aciduria (HP:0003215)1.87827912
83Ketoacidosis (HP:0001993)1.87045026
84Lissencephaly (HP:0001339)1.87040069
85Abnormal drinking behavior (HP:0030082)1.85396159
86Polydipsia (HP:0001959)1.85396159
87Abnormality of macular pigmentation (HP:0008002)1.84167184
88Specific learning disability (HP:0001328)1.83336741
89Hypoglycemic seizures (HP:0002173)1.83293138
90Double outlet right ventricle (HP:0001719)1.82245162
91Congenital malformation of the right heart (HP:0011723)1.82245162
92Sclerocornea (HP:0000647)1.79564988
93Abnormal spermatogenesis (HP:0008669)1.78937135
94Congenital hepatic fibrosis (HP:0002612)1.78464004
95Respiratory failure (HP:0002878)1.77631525
96Aplasia/Hypoplasia of the lens (HP:0008063)1.76732307
97Type II lissencephaly (HP:0007260)1.76400466
98Postaxial hand polydactyly (HP:0001162)1.75996666
99Increased serum lactate (HP:0002151)1.73063114
100Lethargy (HP:0001254)1.72250938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.08209946
2MAP4K23.50927460
3PLK42.68132947
4NME12.66939503
5MST42.58811574
6PLK22.58367696
7NEK12.44246819
8TSSK62.30949616
9WNK32.30471200
10TRIM282.20599999
11EIF2AK12.20537209
12BCKDK2.12572269
13LMTK22.10266318
14EIF2AK31.84415525
15ADRBK21.78101535
16ERBB31.72535078
17MKNK21.68401697
18MAP3K41.67237429
19BMPR1B1.64389345
20BRSK21.62752060
21CAMKK21.61019277
22PLK31.60608405
23GRK11.59290711
24BUB11.52023313
25BMPR21.51383975
26NUAK11.50254025
27PAK31.46065301
28SRPK11.43751120
29AKT31.34573019
30INSRR1.32013052
31CSNK1G11.28697848
32MAPK131.21361185
33MARK11.18697795
34STK161.13029637
35TNIK1.12580375
36PIK3CA1.11652399
37MKNK11.11550221
38CSNK1G31.06382048
39CSNK1G21.03519783
40MAP2K71.03124058
41STK390.99377414
42BCR0.95863878
43DDR20.94412563
44BRD40.93830005
45FER0.93620498
46ZAK0.93234345
47PRKD30.92272539
48FLT30.89103473
49PRKCE0.84400700
50WEE10.82688959
51VRK10.82220268
52NLK0.81904014
53PNCK0.81597584
54TXK0.81178927
55PLK10.80204739
56WNK40.77898216
57BRSK10.77879654
58PRKCI0.76831774
59TTK0.76649974
60NEK60.75114921
61OXSR10.71692045
62TNK20.69931250
63CSNK1A1L0.68488544
64PRKG20.67240922
65PRKCG0.66988830
66OBSCN0.66087936
67PKN10.64706804
68PHKG20.64049662
69PHKG10.64049662
70ATM0.63995432
71PINK10.61713593
72TAOK30.61369148
73PRKACB0.58745764
74CDC70.56944807
75MAP3K120.53238669
76PRKG10.51505009
77ADRBK10.51158283
78STK38L0.50577786
79CAMK2A0.49759479
80CLK10.49236155
81PBK0.49047159
82LIMK10.46405768
83PIK3CG0.45919813
84CAMK10.45214989
85MAP2K60.45048166
86MAP3K30.44435851
87PTK2B0.43727186
88CASK0.43556888
89CSNK1D0.39128769
90PRKACA0.36335360
91CSNK1A10.35968041
92ROCK10.35565587
93STK100.34193071
94EIF2AK20.34166527
95PRKAA10.33033730
96PRKCQ0.30411626
97IKBKB0.30159731
98FGFR20.29550645
99MINK10.28892423
100MYLK0.28454563

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.87339892
2Proteasome_Homo sapiens_hsa030503.79609188
3Non-homologous end-joining_Homo sapiens_hsa034503.25603082
4Protein export_Homo sapiens_hsa030603.24494705
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65423139
6Fatty acid elongation_Homo sapiens_hsa000622.56575544
7Propanoate metabolism_Homo sapiens_hsa006402.45688181
8One carbon pool by folate_Homo sapiens_hsa006702.43246652
9RNA polymerase_Homo sapiens_hsa030202.39496529
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38472234
11RNA degradation_Homo sapiens_hsa030182.02432328
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92175641
13Steroid biosynthesis_Homo sapiens_hsa001001.80508584
14Oxidative phosphorylation_Homo sapiens_hsa001901.78279424
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77091085
16Butanoate metabolism_Homo sapiens_hsa006501.71581154
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69270926
18Vitamin B6 metabolism_Homo sapiens_hsa007501.69029610
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68214413
20Basal transcription factors_Homo sapiens_hsa030221.67414885
21Homologous recombination_Homo sapiens_hsa034401.63788124
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54620559
23Phototransduction_Homo sapiens_hsa047441.52134640
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.50830423
25Parkinsons disease_Homo sapiens_hsa050121.38716085
26Mismatch repair_Homo sapiens_hsa034301.37223306
27Fatty acid metabolism_Homo sapiens_hsa012121.36862683
28Regulation of autophagy_Homo sapiens_hsa041401.31764783
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30822327
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29849551
31Peroxisome_Homo sapiens_hsa041461.25462714
32Fanconi anemia pathway_Homo sapiens_hsa034601.24849841
33Glutathione metabolism_Homo sapiens_hsa004801.20385994
34Huntingtons disease_Homo sapiens_hsa050161.12680994
35Caffeine metabolism_Homo sapiens_hsa002321.11275315
36Selenocompound metabolism_Homo sapiens_hsa004501.06886629
37Purine metabolism_Homo sapiens_hsa002301.04950966
38Circadian rhythm_Homo sapiens_hsa047101.03432063
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98057378
40Folate biosynthesis_Homo sapiens_hsa007900.95734137
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.95428316
42Fatty acid biosynthesis_Homo sapiens_hsa000610.93244008
43Collecting duct acid secretion_Homo sapiens_hsa049660.93214697
44Tryptophan metabolism_Homo sapiens_hsa003800.90809876
45RNA transport_Homo sapiens_hsa030130.89698579
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85944427
47Fatty acid degradation_Homo sapiens_hsa000710.85294458
48Pyrimidine metabolism_Homo sapiens_hsa002400.84871767
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83804754
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82886005
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.82769919
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82062846
53Nitrogen metabolism_Homo sapiens_hsa009100.81612245
54Olfactory transduction_Homo sapiens_hsa047400.80469255
55Chemical carcinogenesis_Homo sapiens_hsa052040.80459826
56Mineral absorption_Homo sapiens_hsa049780.79835583
57Taste transduction_Homo sapiens_hsa047420.77802715
58beta-Alanine metabolism_Homo sapiens_hsa004100.76429246
59Retinol metabolism_Homo sapiens_hsa008300.74671898
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74453430
61Metabolic pathways_Homo sapiens_hsa011000.73933349
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73372497
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.72030023
64Linoleic acid metabolism_Homo sapiens_hsa005910.70877721
65Type I diabetes mellitus_Homo sapiens_hsa049400.70371719
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68724089
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68380549
68Ether lipid metabolism_Homo sapiens_hsa005650.67519841
69Nucleotide excision repair_Homo sapiens_hsa034200.66125521
70Alzheimers disease_Homo sapiens_hsa050100.64645692
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62742348
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62676854
73ABC transporters_Homo sapiens_hsa020100.62228820
74Carbon metabolism_Homo sapiens_hsa012000.58587724
75Base excision repair_Homo sapiens_hsa034100.58308744
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56624995
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54810672
78Insulin secretion_Homo sapiens_hsa049110.54047766
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49439657
80Arginine and proline metabolism_Homo sapiens_hsa003300.49394985
81Spliceosome_Homo sapiens_hsa030400.47857815
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47165138
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45025008
84Cardiac muscle contraction_Homo sapiens_hsa042600.44234076
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43330892
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38420487
87Sphingolipid metabolism_Homo sapiens_hsa006000.35979480
88Vibrio cholerae infection_Homo sapiens_hsa051100.33820426
89Vitamin digestion and absorption_Homo sapiens_hsa049770.32696332
90Synaptic vesicle cycle_Homo sapiens_hsa047210.32180037
91Oocyte meiosis_Homo sapiens_hsa041140.31573606
92Biosynthesis of amino acids_Homo sapiens_hsa012300.30096839
93Salivary secretion_Homo sapiens_hsa049700.29939630
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29615654
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29230634
96N-Glycan biosynthesis_Homo sapiens_hsa005100.28725473
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27744165
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27472469
99Tight junction_Homo sapiens_hsa045300.26098749
100Primary immunodeficiency_Homo sapiens_hsa053400.24201893

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