ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.12325563
2	ribosomal small subunit assembly (GO:0000028)	4.95792001
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.83999364
4	ATP synthesis coupled proton transport (GO:0015986)	4.83999364
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.66215061
6	cytidine metabolic process (GO:0046087)	4.62863234
7	cytidine catabolic process (GO:0006216)	4.62863234
8	cytidine deamination (GO:0009972)	4.62863234
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.57837844
10	protein neddylation (GO:0045116)	4.08431993
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.97802357
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.96273192
13	respiratory electron transport chain (GO:0022904)	3.58087651
14	electron transport chain (GO:0022900)	3.56365509
15	viral transcription (GO:0019083)	3.55376950
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.49604634
17	maturation of SSU-rRNA (GO:0030490)	3.47784729
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47429493
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47429493
20	ribosomal large subunit biogenesis (GO:0042273)	3.47139988
21	translational termination (GO:0006415)	3.44532437
22	protein complex biogenesis (GO:0070271)	3.37895218
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.37582346
24	behavioral response to nicotine (GO:0035095)	3.36055302
25	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.30097749
26	cotranslational protein targeting to membrane (GO:0006613)	3.23745760
27	protein targeting to ER (GO:0045047)	3.21658349
28	response to pheromone (GO:0019236)	3.18837657
29	translational elongation (GO:0006414)	3.16740021
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.12048107
31	NADH dehydrogenase complex assembly (GO:0010257)	3.12048107
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.12048107
33	protein localization to endoplasmic reticulum (GO:0070972)	3.10650730
34	kynurenine metabolic process (GO:0070189)	3.08148058
35	negative regulation of mast cell activation (GO:0033004)	3.07419923
36	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.05807067
37	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95782085
38	indole-containing compound catabolic process (GO:0042436)	2.93223441
39	indolalkylamine catabolic process (GO:0046218)	2.93223441
40	tryptophan catabolic process (GO:0006569)	2.93223441
41	platelet dense granule organization (GO:0060155)	2.90958074
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.89405808
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.84272077
44	GPI anchor metabolic process (GO:0006505)	2.83676736
45	ATP biosynthetic process (GO:0006754)	2.83479713
46	regulation of regulatory T cell differentiation (GO:0045589)	2.82648954
47	mast cell activation (GO:0045576)	2.82234427
48	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.82040793
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.81228267
50	hydrogen ion transmembrane transport (GO:1902600)	2.79734709
51	proteasome assembly (GO:0043248)	2.79007365
52	respiratory chain complex IV assembly (GO:0008535)	2.78648238
53	proton transport (GO:0015992)	2.76507469
54	positive regulation of defense response to virus by host (GO:0002230)	2.74837180
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.73334689
56	termination of RNA polymerase III transcription (GO:0006386)	2.73334689
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72735504
58	hydrogen transport (GO:0006818)	2.72557249
59	regulation of cellular amino acid metabolic process (GO:0006521)	2.72269778
60	GPI anchor biosynthetic process (GO:0006506)	2.71127262
61	mannosylation (GO:0097502)	2.69591702
62	piRNA metabolic process (GO:0034587)	2.69201245
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.69182072
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.68996020
65	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.67788634
66	axoneme assembly (GO:0035082)	2.66183053
67	indolalkylamine metabolic process (GO:0006586)	2.65887357
68	DNA demethylation (GO:0080111)	2.65411679
69	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.64932943
70	translation (GO:0006412)	2.64879409
71	positive thymic T cell selection (GO:0045059)	2.63320666
72	tryptophan metabolic process (GO:0006568)	2.62875966
73	positive regulation of prostaglandin secretion (GO:0032308)	2.62533493
74	cytochrome complex assembly (GO:0017004)	2.62128003
75	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.59147635
76	rRNA catabolic process (GO:0016075)	2.59134749
77	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.58958512
78	positive regulation of interleukin-17 production (GO:0032740)	2.57231989
79	mast cell activation involved in immune response (GO:0002279)	2.55369674
80	mast cell degranulation (GO:0043303)	2.55369674
81	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.54429498
82	regulation of interleukin-8 secretion (GO:2000482)	2.53655570
83	protein-cofactor linkage (GO:0018065)	2.53586914
84	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.53285722
85	positive T cell selection (GO:0043368)	2.53099991
86	negative regulation of heart rate (GO:0010459)	2.52785898
87	translational initiation (GO:0006413)	2.52557239
88	viral life cycle (GO:0019058)	2.52371273
89	negative regulation of T cell apoptotic process (GO:0070233)	2.51429434
90	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.51428558
91	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.49802540
92	DNA dealkylation (GO:0035510)	2.48989250
93	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.47888150
94	metallo-sulfur cluster assembly (GO:0031163)	2.47569907
95	iron-sulfur cluster assembly (GO:0016226)	2.47569907
96	response to interferon-beta (GO:0035456)	2.47459214
97	aldehyde catabolic process (GO:0046185)	2.46433921
98	regulation of T cell mediated cytotoxicity (GO:0001914)	2.45564613
99	cellular protein complex disassembly (GO:0043624)	2.45093090
100	aggressive behavior (GO:0002118)	2.44823641

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54136800
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50395758
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.18024007
4	VDR_22108803_ChIP-Seq_LS180_Human	3.03727698
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91919025
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81775157
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.77134062
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.76075795
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.72301578
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61091819
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32003709
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.28761306
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.26224159
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17625683
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14757618
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.07093846
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01792455
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.88966797
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87356783
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82796136
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.82582801
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80653692
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75106388
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.73578383
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73377884
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.73143435
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72670701
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70207353
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.63042965
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.62296128
31	EWS_26573619_Chip-Seq_HEK293_Human	1.61971718
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61839883
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.60578547
34	GATA3_26560356_Chip-Seq_TH2_Human	1.53938661
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52480092
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47975121
37	AR_20517297_ChIP-Seq_VCAP_Human	1.47968455
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47768058
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47122914
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47122914
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46920683
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.46596760
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46576668
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.44307868
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.42392575
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36593970
47	MYB_26560356_Chip-Seq_TH2_Human	1.34040639
48	FUS_26573619_Chip-Seq_HEK293_Human	1.33921486
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.32556792
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32183007
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32183007
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31366785
53	P300_19829295_ChIP-Seq_ESCs_Human	1.29233270
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29196846
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27388074
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27238682
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23438135
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23352101
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22289671
60	NCOR_22424771_ChIP-Seq_293T_Human	1.22139456
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21158977
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.21158977
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21091989
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21029891
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20108141
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19675936
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19325572
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17443413
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16018959
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15001467
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14746197
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14593995
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12282266
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11812382
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10939829
76	GATA3_27048872_Chip-Seq_THYMUS_Human	1.09190665
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06833678
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06771168
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06269486
80	GBX2_23144817_ChIP-Seq_PC3_Human	1.05974402
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05519303
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.05475483
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05276133
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02906953
85	ERG_20517297_ChIP-Seq_VCAP_Human	1.02281787
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.01335676
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01066152
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00581174
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00252436
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99844251
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98456881
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98315343
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98112463
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97186981
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97141193
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.96903273
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96009376
98	RUNX_20019798_ChIP-Seq_JUKART_Human	0.92328957
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92032308
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91758468

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.02913708
2	MP0001835_abnormal_antigen_presentation	3.55280972
3	MP0009379_abnormal_foot_pigmentation	2.64696902
4	MP0006292_abnormal_olfactory_placode	2.42829210
5	MP0009785_altered_susceptibility_to	2.22774506
6	MP0008875_abnormal_xenobiotic_pharmacok	2.19260123
7	MP0006072_abnormal_retinal_apoptosis	2.16194725
8	MP0004147_increased_porphyrin_level	2.09212236
9	MP0008877_abnormal_DNA_methylation	2.06913311
10	MP0002102_abnormal_ear_morphology	1.94120428
11	MP0008872_abnormal_physiological_respon	1.93700696
12	MP0003806_abnormal_nucleotide_metabolis	1.93096106
13	MP0002148_abnormal_hypersensitivity_rea	1.91721650
14	MP0003646_muscle_fatigue	1.90097206
15	MP0001800_abnormal_humoral_immune	1.87558231
16	MP0005645_abnormal_hypothalamus_physiol	1.82010591
17	MP0005646_abnormal_pituitary_gland	1.79177865
18	MP0001986_abnormal_taste_sensitivity	1.77956351
19	MP0004885_abnormal_endolymph	1.77842266
20	MP0005084_abnormal_gallbladder_morpholo	1.74862423
21	MP0005075_abnormal_melanosome_morpholog	1.74423287
22	MP0002138_abnormal_hepatobiliary_system	1.73639873
23	MP0004142_abnormal_muscle_tone	1.73493281
24	MP0005551_abnormal_eye_electrophysiolog	1.72917394
25	MP0005000_abnormal_immune_tolerance	1.71699279
26	MP0000372_irregular_coat_pigmentation	1.68086210
27	MP0001968_abnormal_touch/_nociception	1.63699372
28	MP0004145_abnormal_muscle_electrophysio	1.59248667
29	MP0002837_dystrophic_cardiac_calcinosis	1.57147462
30	MP0001873_stomach_inflammation	1.56878368
31	MP0002723_abnormal_immune_serum	1.53247016
32	MP0005377_hearing/vestibular/ear_phenot	1.51654848
33	MP0003878_abnormal_ear_physiology	1.51654848
34	MP0000685_abnormal_immune_system	1.51119925
35	MP0009764_decreased_sensitivity_to	1.44129957
36	MP0003866_abnormal_defecation	1.43892691
37	MP0002166_altered_tumor_susceptibility	1.43666928
38	MP0002420_abnormal_adaptive_immunity	1.39447027
39	MP0001819_abnormal_immune_cell	1.38685580
40	MP0001790_abnormal_immune_system	1.38572921
41	MP0005387_immune_system_phenotype	1.38572921
42	MP0002876_abnormal_thyroid_physiology	1.38140804
43	MP0002452_abnormal_antigen_presenting	1.37059990
44	MP0002006_tumorigenesis	1.35751722
45	MP0009333_abnormal_splenocyte_physiolog	1.35410670
46	MP0003763_abnormal_thymus_physiology	1.33547433
47	MP0002736_abnormal_nociception_after	1.32431400
48	MP0005389_reproductive_system_phenotype	1.29693581
49	MP0003195_calcinosis	1.27896991
50	MP0001905_abnormal_dopamine_level	1.27363668
51	MP0003787_abnormal_imprinting	1.26841929
52	MP0003011_delayed_dark_adaptation	1.24555504
53	MP0006276_abnormal_autonomic_nervous	1.23514471
54	MP0005253_abnormal_eye_physiology	1.22091290
55	MP0003724_increased_susceptibility_to	1.20828886
56	MP0001919_abnormal_reproductive_system	1.17543153
57	MP0005025_abnormal_response_to	1.16361506
58	MP0001501_abnormal_sleep_pattern	1.15329380
59	MP0001984_abnormal_olfaction	1.12443079
60	MP0004742_abnormal_vestibular_system	1.11764337
61	MP0003786_premature_aging	1.09979233
62	MP0008995_early_reproductive_senescence	1.08696767
63	MP0002160_abnormal_reproductive_system	1.04855741
64	MP0010155_abnormal_intestine_physiology	1.04815876
65	MP0003880_abnormal_central_pattern	1.02232203
66	MP0002272_abnormal_nervous_system	1.01896470
67	MP0001485_abnormal_pinna_reflex	1.01589559
68	MP0002163_abnormal_gland_morphology	1.01170478
69	MP0000716_abnormal_immune_system	1.00597588
70	MP0002398_abnormal_bone_marrow	0.96674859
71	MP0002638_abnormal_pupillary_reflex	0.96264097
72	MP0003252_abnormal_bile_duct	0.94906107
73	MP0001440_abnormal_grooming_behavior	0.94348973
74	MP0006036_abnormal_mitochondrial_physio	0.92871311
75	MP0001970_abnormal_pain_threshold	0.92186785
76	MP0002095_abnormal_skin_pigmentation	0.90159481
77	MP0001845_abnormal_inflammatory_respons	0.88896222
78	MP0005410_abnormal_fertilization	0.88268393
79	MP0001529_abnormal_vocalization	0.87618803
80	MP0008058_abnormal_DNA_repair	0.87425213
81	MP0002733_abnormal_thermal_nociception	0.86471215
82	MP0009745_abnormal_behavioral_response	0.86215042
83	MP0000689_abnormal_spleen_morphology	0.84820547
84	MP0003186_abnormal_redox_activity	0.83687016
85	MP0005636_abnormal_mineral_homeostasis	0.82995861
86	MP0006082_CNS_inflammation	0.82536509
87	MP0002405_respiratory_system_inflammati	0.81265480
88	MP0002277_abnormal_respiratory_mucosa	0.81112475
89	MP0002234_abnormal_pharynx_morphology	0.80652596
90	MP0001764_abnormal_homeostasis	0.79770907
91	MP0005085_abnormal_gallbladder_physiolo	0.79765324
92	MP0001486_abnormal_startle_reflex	0.78633689
93	MP0001765_abnormal_ion_homeostasis	0.76681315
94	MP0005174_abnormal_tail_pigmentation	0.76516398
95	MP0000427_abnormal_hair_cycle	0.76047559
96	MP0002429_abnormal_blood_cell	0.73888699
97	MP0008789_abnormal_olfactory_epithelium	0.73763303
98	MP0001188_hyperpigmentation	0.73544049
99	MP0002419_abnormal_innate_immunity	0.72277840
100	MP0001293_anophthalmia	0.72228537

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.12541530
2	Mitochondrial inheritance (HP:0001427)	3.96878149
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.66554889
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.61981729
5	Increased CSF lactate (HP:0002490)	3.52379370
6	Hepatocellular necrosis (HP:0001404)	3.51687616
7	IgG deficiency (HP:0004315)	3.50963230
8	Acute encephalopathy (HP:0006846)	3.48137726
9	Progressive macrocephaly (HP:0004481)	3.48021830
10	Aplastic anemia (HP:0001915)	3.37146971
11	Pancreatic cysts (HP:0001737)	3.32262659
12	Congenital stationary night blindness (HP:0007642)	3.32009968
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28282894
14	Abnormality of midbrain morphology (HP:0002418)	3.24667349
15	Molar tooth sign on MRI (HP:0002419)	3.24667349
16	Increased hepatocellular lipid droplets (HP:0006565)	3.21376170
17	Hepatic necrosis (HP:0002605)	3.13208185
18	Hypoproteinemia (HP:0003075)	3.11187957
19	3-Methylglutaconic aciduria (HP:0003535)	3.07954190
20	Abolished electroretinogram (ERG) (HP:0000550)	3.03386645
21	Lipid accumulation in hepatocytes (HP:0006561)	3.01016650
22	Pancreatic fibrosis (HP:0100732)	2.88732799
23	Stomatitis (HP:0010280)	2.88716109
24	True hermaphroditism (HP:0010459)	2.87411041
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.82441279
26	Congenital, generalized hypertrichosis (HP:0004540)	2.82203349
27	Renal Fanconi syndrome (HP:0001994)	2.73946878
28	Abnormality of the prostate (HP:0008775)	2.71873729
29	Cerebral edema (HP:0002181)	2.68505171
30	Severe combined immunodeficiency (HP:0004430)	2.61508371
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59113176
32	Decreased central vision (HP:0007663)	2.55650644
33	Increased intramyocellular lipid droplets (HP:0012240)	2.55003551
34	Optic disc pallor (HP:0000543)	2.54613501
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.50896201
36	Nephronophthisis (HP:0000090)	2.50130049
37	Methylmalonic acidemia (HP:0002912)	2.48086729
38	Increased serum lactate (HP:0002151)	2.47472395
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.42501877
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.42501877
41	Attenuation of retinal blood vessels (HP:0007843)	2.39565024
42	Type II lissencephaly (HP:0007260)	2.39385108
43	Type 2 muscle fiber atrophy (HP:0003554)	2.38537455
44	Thyroiditis (HP:0100646)	2.34745592
45	Exertional dyspnea (HP:0002875)	2.33092421
46	Medial flaring of the eyebrow (HP:0010747)	2.32253012
47	Abnormality of the renal cortex (HP:0011035)	2.31494987
48	Abnormal number of erythroid precursors (HP:0012131)	2.31387445
49	Abnormality of B cell number (HP:0010975)	2.30424477
50	Abnormality of T cell number (HP:0011839)	2.28967121
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25831601
52	T lymphocytopenia (HP:0005403)	2.25539853
53	Lactic acidosis (HP:0003128)	2.23444046
54	Increased IgM level (HP:0003496)	2.21171610
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.14248446
56	Absent/shortened dynein arms (HP:0200106)	2.14248446
57	Reticulocytopenia (HP:0001896)	2.13385688
58	Abnormality of the renal medulla (HP:0100957)	2.09963180
59	Renal cortical cysts (HP:0000803)	2.09828612
60	Increased muscle lipid content (HP:0009058)	2.08922584
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07633770
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04599867
63	Abnormality of alanine metabolism (HP:0010916)	2.04599867
64	Hyperalaninemia (HP:0003348)	2.04599867
65	Lethargy (HP:0001254)	2.03882622
66	Methylmalonic aciduria (HP:0012120)	2.03816541
67	Sclerocornea (HP:0000647)	2.03682775
68	Abnormality of T cells (HP:0002843)	2.03095733
69	Pendular nystagmus (HP:0012043)	1.97692511
70	Respiratory failure (HP:0002878)	1.92875589
71	Keratoconus (HP:0000563)	1.90090026
72	Increased corneal curvature (HP:0100692)	1.90090026
73	Constricted visual fields (HP:0001133)	1.88822898
74	Pancytopenia (HP:0001876)	1.88659727
75	Abnormality of eosinophils (HP:0001879)	1.87823278
76	Macrocytic anemia (HP:0001972)	1.87788091
77	Abnormality of urine glucose concentration (HP:0011016)	1.87331926
78	Glycosuria (HP:0003076)	1.87331926
79	Cystic liver disease (HP:0006706)	1.87263719
80	Muscle fiber atrophy (HP:0100295)	1.86463751
81	Combined immunodeficiency (HP:0005387)	1.85833541
82	B lymphocytopenia (HP:0010976)	1.85639060
83	Abnormality of DNA repair (HP:0003254)	1.84080446
84	Autoimmune hemolytic anemia (HP:0001890)	1.82372450
85	Leukodystrophy (HP:0002415)	1.81466404
86	Abnormality of renal resorption (HP:0011038)	1.78844044
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78059091
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78044940
89	Absent thumb (HP:0009777)	1.77780180
90	Generalized aminoaciduria (HP:0002909)	1.77490116
91	Colon cancer (HP:0003003)	1.75845495
92	Polydipsia (HP:0001959)	1.75843706
93	Abnormal drinking behavior (HP:0030082)	1.75843706
94	Stenosis of the external auditory canal (HP:0000402)	1.75436075
95	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.74000897
96	Panhypogammaglobulinemia (HP:0003139)	1.73437179
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.70904917
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70904917
99	Hypothermia (HP:0002045)	1.70229004
100	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.66573991

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.32631006
2	TAOK3	3.63616755
3	MAP4K2	3.18950960
4	CDK19	3.02995233
5	TLK1	2.88506690
6	ZAK	2.66800029
7	KDR	2.37140602
8	ADRBK2	2.36651695
9	FRK	2.34255666
10	NUAK1	2.30056584
11	BCKDK	2.20418401
12	GRK1	2.14219987
13	STK16	2.05982702
14	MAP4K1	2.01554659
15	MAP3K12	1.95647391
16	PINK1	1.79091100
17	VRK2	1.78842851
18	ITK	1.53676858
19	BMPR2	1.52946831
20	KIT	1.48473343
21	WNK4	1.46517688
22	WNK3	1.43656760
23	TEC	1.40147946
24	EIF2AK3	1.37924605
25	MST4	1.37084942
26	FES	1.35810912
27	SYK	1.26900231
28	IKBKB	1.25963231
29	VRK1	1.22126052
30	OXSR1	1.20467569
31	TIE1	1.18554695
32	BMPR1B	1.15617107
33	MYLK	1.13114922
34	INSRR	1.09963826
35	CSF1R	1.00670845
36	BTK	1.00438828
37	ERBB3	0.99679794
38	PASK	0.94298053
39	MAPK13	0.86879450
40	PRKCQ	0.85984244
41	GRK6	0.85261287
42	PIK3CA	0.82607584
43	LYN	0.81680936
44	LCK	0.81587501
45	MUSK	0.80110498
46	DYRK2	0.79324524
47	PHKG1	0.77773301
48	PHKG2	0.77773301
49	FLT3	0.77157352
50	CAMKK2	0.76359500
51	SCYL2	0.74373564
52	TRIM28	0.73764482
53	RPS6KA5	0.71850271
54	IKBKE	0.71360730
55	DAPK1	0.67032273
56	CSNK1G3	0.66721025
57	ADRBK1	0.62853011
58	GRK7	0.62779216
59	JAK3	0.61485628
60	STK39	0.61228692
61	TRPM7	0.60931923
62	IGF1R	0.60559873
63	CSNK1G1	0.58390351
64	OBSCN	0.58361140
65	NME1	0.55522756
66	TNK2	0.55484556
67	DAPK2	0.54288348
68	MAPKAPK3	0.53701573
69	CSNK1G2	0.53607873
70	EIF2AK2	0.53369357
71	MAP3K4	0.51947946
72	PLK2	0.50834147
73	LIMK1	0.48686903
74	PRKCE	0.47842048
75	MAP2K6	0.47452128
76	TESK2	0.46709292
77	DAPK3	0.45955606
78	PRKCA	0.45414803
79	PRKACA	0.45041177
80	MATK	0.45013262
81	MAPKAPK5	0.43743185
82	CAMKK1	0.43072961
83	MKNK1	0.42143509
84	PLK4	0.41018159
85	PIK3CG	0.40568650
86	MAP2K7	0.40258835
87	PLK3	0.39423203
88	CSNK1A1L	0.38522039
89	MAP3K14	0.37510622
90	CDK8	0.36954345
91	ABL1	0.36911945
92	ILK	0.36867790
93	RPS6KA4	0.35820060
94	HCK	0.35290546
95	CSNK2A2	0.34754519
96	CSNK2A1	0.34659828
97	ZAP70	0.33955110
98	ATR	0.32649248
99	CSNK1A1	0.31881550
100	CAMK2A	0.31841548

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.86395236
2	Allograft rejection_Homo sapiens_hsa05330	3.38042773
3	Proteasome_Homo sapiens_hsa03050	3.28411715
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.28253242
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.25672335
6	Ribosome_Homo sapiens_hsa03010	3.19693751
7	Graft-versus-host disease_Homo sapiens_hsa05332	3.16626485
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.96240074
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.70987300
10	Parkinsons disease_Homo sapiens_hsa05012	2.68141919
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.50352695
12	Protein export_Homo sapiens_hsa03060	2.23656718
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.19868186
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86281491
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80108845
16	RNA polymerase_Homo sapiens_hsa03020	1.74425047
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.73445392
18	Alzheimers disease_Homo sapiens_hsa05010	1.72908934
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.68639836
20	Phototransduction_Homo sapiens_hsa04744	1.59679748
21	Huntingtons disease_Homo sapiens_hsa05016	1.59634306
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54269728
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50879131
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50789028
25	Caffeine metabolism_Homo sapiens_hsa00232	1.46804253
26	RNA degradation_Homo sapiens_hsa03018	1.36295106
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31300860
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.29469407
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23434342
30	Homologous recombination_Homo sapiens_hsa03440	1.23307289
31	Viral myocarditis_Homo sapiens_hsa05416	1.20733652
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.13256412
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09902171
34	Propanoate metabolism_Homo sapiens_hsa00640	1.02732393
35	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.02431819
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01187716
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98352372
38	One carbon pool by folate_Homo sapiens_hsa00670	0.92714630
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91430940
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88998764
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88761099
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.88459051
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87175345
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87115220
45	Peroxisome_Homo sapiens_hsa04146	0.86116620
46	Basal transcription factors_Homo sapiens_hsa03022	0.85960086
47	Olfactory transduction_Homo sapiens_hsa04740	0.85582472
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79287123
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78619063
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.75242309
51	Butanoate metabolism_Homo sapiens_hsa00650	0.74191374
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73946906
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72507140
54	Leishmaniasis_Homo sapiens_hsa05140	0.71774122
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71302379
56	Retinol metabolism_Homo sapiens_hsa00830	0.70173758
57	Regulation of autophagy_Homo sapiens_hsa04140	0.69993254
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68404882
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.67185298
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67115824
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66747862
62	Purine metabolism_Homo sapiens_hsa00230	0.66528522
63	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64163536
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63134122
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60269930
66	Nicotine addiction_Homo sapiens_hsa05033	0.59396484
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.58904116
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57880691
69	Mismatch repair_Homo sapiens_hsa03430	0.55719603
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55518627
71	Spliceosome_Homo sapiens_hsa03040	0.55415167
72	RNA transport_Homo sapiens_hsa03013	0.53665711
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52927734
74	Sulfur metabolism_Homo sapiens_hsa00920	0.52691961
75	Taste transduction_Homo sapiens_hsa04742	0.49924691
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46575739
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46493561
78	Metabolic pathways_Homo sapiens_hsa01100	0.46241334
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43742688
80	Herpes simplex infection_Homo sapiens_hsa05168	0.42975567
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41932693
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40033582
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.39774574
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39320075
85	Morphine addiction_Homo sapiens_hsa05032	0.37508108
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.34057849
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33927159
88	Salivary secretion_Homo sapiens_hsa04970	0.33298931
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31470548
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31228616
91	Fatty acid elongation_Homo sapiens_hsa00062	0.30501606
92	Base excision repair_Homo sapiens_hsa03410	0.29748599
93	Malaria_Homo sapiens_hsa05144	0.27064038
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25682757
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25455994
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.23344985
97	Serotonergic synapse_Homo sapiens_hsa04726	0.22989080
98	Measles_Homo sapiens_hsa05162	0.22926611
99	DNA replication_Homo sapiens_hsa03030	0.22790998
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22158901

RPL7P47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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