ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.18148073
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.18148073
3	positive regulation of respiratory burst (GO:0060267)	5.02648337
4	DNA deamination (GO:0045006)	4.90799694
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.89926492
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.36224332
7	ribosomal small subunit assembly (GO:0000028)	4.09725296
8	viral transcription (GO:0019083)	3.93080261
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.84005941
10	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.84005941
11	protein neddylation (GO:0045116)	3.75773603
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.74166810
13	translational termination (GO:0006415)	3.72923058
14	positive regulation of prostaglandin secretion (GO:0032308)	3.67743566
15	electron transport chain (GO:0022900)	3.65395334
16	respiratory electron transport chain (GO:0022904)	3.64521135
17	cytidine deamination (GO:0009972)	3.59879946
18	cytidine metabolic process (GO:0046087)	3.59879946
19	cytidine catabolic process (GO:0006216)	3.59879946
20	behavioral response to nicotine (GO:0035095)	3.48646417
21	regulation of regulatory T cell differentiation (GO:0045589)	3.47798743
22	chaperone-mediated protein transport (GO:0072321)	3.43219464
23	fucose catabolic process (GO:0019317)	3.42396516
24	L-fucose metabolic process (GO:0042354)	3.42396516
25	L-fucose catabolic process (GO:0042355)	3.42396516
26	protein complex biogenesis (GO:0070271)	3.40305635
27	maturation of SSU-rRNA (GO:0030490)	3.35548360
28	ubiquinone biosynthetic process (GO:0006744)	3.30995308
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.27765378
30	translational elongation (GO:0006414)	3.27404639
31	protein targeting to ER (GO:0045047)	3.27233099
32	sulfation (GO:0051923)	3.25380463
33	cotranslational protein targeting to membrane (GO:0006613)	3.25045768
34	ribosomal small subunit biogenesis (GO:0042274)	3.21823405
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20700898
36	respiratory chain complex IV assembly (GO:0008535)	3.17277306
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16140884
38	positive regulation of fatty acid transport (GO:2000193)	3.15722624
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13818071
40	cytochrome complex assembly (GO:0017004)	3.13409644
41	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.11427592
42	regulation of immunoglobulin secretion (GO:0051023)	3.10817056
43	rRNA modification (GO:0000154)	3.09895313
44	protein localization to endoplasmic reticulum (GO:0070972)	3.09785391
45	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.08513055
46	quinone biosynthetic process (GO:1901663)	3.08225230
47	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.07415488
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.03522718
49	NADH dehydrogenase complex assembly (GO:0010257)	3.03522718
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.03522718
51	regulation of prostaglandin secretion (GO:0032306)	3.02773308
52	cellular response to interferon-beta (GO:0035458)	3.02622234
53	mitochondrial respiratory chain complex assembly (GO:0033108)	3.02052537
54	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.00749823
55	protein-cofactor linkage (GO:0018065)	2.98537232
56	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.97818003
57	ATP biosynthetic process (GO:0006754)	2.95089129
58	antibacterial humoral response (GO:0019731)	2.95017807
59	ribosomal large subunit biogenesis (GO:0042273)	2.93968694
60	hydrogen ion transmembrane transport (GO:1902600)	2.93596488
61	kynurenine metabolic process (GO:0070189)	2.92807170
62	ubiquinone metabolic process (GO:0006743)	2.92256539
63	negative regulation of B cell apoptotic process (GO:0002903)	2.92243431
64	positive regulation of icosanoid secretion (GO:0032305)	2.89524058
65	rRNA catabolic process (GO:0016075)	2.88100564
66	positive regulation of defense response to virus by host (GO:0002230)	2.86044186
67	indolalkylamine catabolic process (GO:0046218)	2.85842464
68	tryptophan catabolic process (GO:0006569)	2.85842464
69	indole-containing compound catabolic process (GO:0042436)	2.85842464
70	response to interferon-beta (GO:0035456)	2.85724982
71	regulation of guanylate cyclase activity (GO:0031282)	2.83163400
72	viral life cycle (GO:0019058)	2.80265858
73	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.79886166
74	proton transport (GO:0015992)	2.79798327
75	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.79345053
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.77919970
77	termination of RNA polymerase III transcription (GO:0006386)	2.77919970
78	hydrogen transport (GO:0006818)	2.77156031
79	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.76311374
80	arginine metabolic process (GO:0006525)	2.74322247
81	regulation of respiratory burst (GO:0060263)	2.72621193
82	vitamin biosynthetic process (GO:0009110)	2.68864452
83	translation (GO:0006412)	2.66599192
84	cellular response to exogenous dsRNA (GO:0071360)	2.66257213
85	drug catabolic process (GO:0042737)	2.66214592
86	cellular protein complex disassembly (GO:0043624)	2.65975280
87	antimicrobial humoral response (GO:0019730)	2.64938198
88	mannosylation (GO:0097502)	2.64846065
89	positive regulation of guanylate cyclase activity (GO:0031284)	2.63748779
90	kidney morphogenesis (GO:0060993)	2.63747394
91	pseudouridine synthesis (GO:0001522)	2.63510865
92	piRNA metabolic process (GO:0034587)	2.60512956
93	translational initiation (GO:0006413)	2.58597613
94	proteasome assembly (GO:0043248)	2.57362545
95	regulation of triglyceride catabolic process (GO:0010896)	2.57041196
96	cellular component biogenesis (GO:0044085)	2.51079996
97	negative regulation of mast cell activation (GO:0033004)	2.51033637
98	rRNA methylation (GO:0031167)	2.49223031
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.46845141
100	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.46091261

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.55520450
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.52736542
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.47726277
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.17831473
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14638002
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.04641804
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.95474102
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72726849
9	VDR_22108803_ChIP-Seq_LS180_Human	2.67635292
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67467746
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.54981594
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48094505
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.47870360
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.44939128
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40762207
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07247630
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.06567469
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.83301264
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77917622
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75240506
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.74864578
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.67340982
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67010836
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66566088
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66154768
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66116693
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.65645821
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63664849
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.62980568
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.62980568
31	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.60790615
32	EWS_26573619_Chip-Seq_HEK293_Human	1.60637772
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59383562
34	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.55827753
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54842728
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.53071644
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50755870
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48543589
39	STAT1_20625510_ChIP-Seq_HELA_Human	1.42528724
40	AR_20517297_ChIP-Seq_VCAP_Human	1.41644015
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40595277
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40463126
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39596851
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39514093
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39311422
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39174926
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.38078964
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34026993
49	GATA3_26560356_Chip-Seq_TH2_Human	1.33538187
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32535043
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.32056201
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30351830
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.29516349
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.28822116
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28765644
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28765644
57	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.28544149
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27805237
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25503205
60	FUS_26573619_Chip-Seq_HEK293_Human	1.24686213
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23938274
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23099880
63	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.22672766
64	ERA_21632823_ChIP-Seq_H3396_Human	1.19053505
65	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18079462
66	NCOR_22424771_ChIP-Seq_293T_Human	1.16873306
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16659277
68	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15017255
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14736690
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12802373
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.09923372
72	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09494173
73	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06251718
74	TTF2_22483619_ChIP-Seq_HELA_Human	1.05880449
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04963503
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04551286
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04396323
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02753137
79	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01819495
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01478019
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01423228
82	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01401875
83	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01368971
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.01283441
85	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00179331
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00013170
87	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99397682
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96722353
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.95799062
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95110318
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94475890
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94298068
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93966493
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93562633
95	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92987201
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92909418
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92879568
98	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.92287747
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90767233
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89483586

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.42109495
2	MP0002138_abnormal_hepatobiliary_system	4.02139375
3	MP0006292_abnormal_olfactory_placode	3.19827195
4	MP0001835_abnormal_antigen_presentation	2.83914290
5	MP0005360_urolithiasis	2.61040791
6	MP0000685_abnormal_immune_system	2.60543470
7	MP0005671_abnormal_response_to	2.47782937
8	MP0002876_abnormal_thyroid_physiology	2.27150357
9	MP0002139_abnormal_hepatobiliary_system	2.23579498
10	MP0008872_abnormal_physiological_respon	2.18923472
11	MP0008875_abnormal_xenobiotic_pharmacok	2.14737327
12	MP0002148_abnormal_hypersensitivity_rea	2.03574111
13	MP0005645_abnormal_hypothalamus_physiol	1.96211034
14	MP0002102_abnormal_ear_morphology	1.92498318
15	MP0003646_muscle_fatigue	1.86199619
16	MP0005085_abnormal_gallbladder_physiolo	1.85010896
17	MP0001790_abnormal_immune_system	1.82286259
18	MP0005387_immune_system_phenotype	1.82286259
19	MP0010155_abnormal_intestine_physiology	1.81605601
20	MP0001968_abnormal_touch/_nociception	1.78719334
21	MP0001800_abnormal_humoral_immune	1.74198397
22	MP0005646_abnormal_pituitary_gland	1.70593371
23	MP0003718_maternal_effect	1.70187542
24	MP0003724_increased_susceptibility_to	1.67771606
25	MP0001986_abnormal_taste_sensitivity	1.67738328
26	MP0009764_decreased_sensitivity_to	1.64788621
27	MP0003806_abnormal_nucleotide_metabolis	1.63274646
28	MP0001293_anophthalmia	1.59483720
29	MP0006072_abnormal_retinal_apoptosis	1.53171582
30	MP0002736_abnormal_nociception_after	1.48537227
31	MP0004019_abnormal_vitamin_homeostasis	1.45678594
32	MP0004885_abnormal_endolymph	1.42124036
33	MP0005000_abnormal_immune_tolerance	1.39949001
34	MP0003252_abnormal_bile_duct	1.32711549
35	MP0004147_increased_porphyrin_level	1.31936402
36	MP0005551_abnormal_eye_electrophysiolog	1.29720684
37	MP0002723_abnormal_immune_serum	1.26475865
38	MP0001666_abnormal_nutrient_absorption	1.26336337
39	MP0002234_abnormal_pharynx_morphology	1.26079984
40	MP0004142_abnormal_muscle_tone	1.25163735
41	MP0003878_abnormal_ear_physiology	1.24735384
42	MP0005377_hearing/vestibular/ear_phenot	1.24735384
43	MP0003866_abnormal_defecation	1.24691886
44	MP0009785_altered_susceptibility_to	1.23500630
45	MP0001845_abnormal_inflammatory_respons	1.21001681
46	MP0003011_delayed_dark_adaptation	1.20836239
47	MP0005084_abnormal_gallbladder_morpholo	1.18656326
48	MP0003283_abnormal_digestive_organ	1.18128158
49	MP0002452_abnormal_antigen_presenting	1.16420913
50	MP0008789_abnormal_olfactory_epithelium	1.12912151
51	MP0005075_abnormal_melanosome_morpholog	1.12690960
52	MP0002272_abnormal_nervous_system	1.12331477
53	MP0001663_abnormal_digestive_system	1.11515342
54	MP0005389_reproductive_system_phenotype	1.09807747
55	MP0001873_stomach_inflammation	1.09763135
56	MP0001819_abnormal_immune_cell	1.09428035
57	MP0002420_abnormal_adaptive_immunity	1.07897006
58	MP0001501_abnormal_sleep_pattern	1.06947801
59	MP0005025_abnormal_response_to	1.05604281
60	MP0002837_dystrophic_cardiac_calcinosis	1.04735467
61	MP0001919_abnormal_reproductive_system	1.04659665
62	MP0009333_abnormal_splenocyte_physiolog	1.04604189
63	MP0000604_amyloidosis	1.03477183
64	MP0004145_abnormal_muscle_electrophysio	1.02191779
65	MP0008877_abnormal_DNA_methylation	1.01628070
66	MP0005365_abnormal_bile_salt	0.99904377
67	MP0003638_abnormal_response/metabolism_	0.96358289
68	MP0000465_gastrointestinal_hemorrhage	0.96115068
69	MP0005332_abnormal_amino_acid	0.92893208
70	MP0001905_abnormal_dopamine_level	0.92881408
71	MP0008775_abnormal_heart_ventricle	0.91771070
72	MP0006036_abnormal_mitochondrial_physio	0.91661788
73	MP0000427_abnormal_hair_cycle	0.90785212
74	MP0003436_decreased_susceptibility_to	0.89052780
75	MP0005174_abnormal_tail_pigmentation	0.88708189
76	MP0002163_abnormal_gland_morphology	0.88643227
77	MP0002006_tumorigenesis	0.88615581
78	MP0009643_abnormal_urine_homeostasis	0.88080822
79	MP0010329_abnormal_lipoprotein_level	0.87428806
80	MP0003195_calcinosis	0.86958984
81	MP0000013_abnormal_adipose_tissue	0.86441791
82	MP0002638_abnormal_pupillary_reflex	0.85769031
83	MP0005636_abnormal_mineral_homeostasis	0.85262017
84	MP0001765_abnormal_ion_homeostasis	0.82998386
85	MP0003693_abnormal_embryo_hatching	0.82641882
86	MP0002277_abnormal_respiratory_mucosa	0.82312516
87	MP0002160_abnormal_reproductive_system	0.79838710
88	MP0003786_premature_aging	0.78397944
89	MP0001485_abnormal_pinna_reflex	0.77364425
90	MP0002938_white_spotting	0.77185898
91	MP0002095_abnormal_skin_pigmentation	0.76179210
92	MP0002166_altered_tumor_susceptibility	0.75906959
93	MP0009745_abnormal_behavioral_response	0.75501172
94	MP0000716_abnormal_immune_system	0.75160016
95	MP0004043_abnormal_pH_regulation	0.74875166
96	MP0003879_abnormal_hair_cell	0.74294956
97	MP0002733_abnormal_thermal_nociception	0.73693209
98	MP0000538_abnormal_urinary_bladder	0.72826957
99	MP0001348_abnormal_lacrimal_gland	0.72607387
100	MP0005379_endocrine/exocrine_gland_phen	0.71829956

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	3.98562358
2	Acute necrotizing encephalopathy (HP:0006965)	3.84700190
3	IgG deficiency (HP:0004315)	3.78653949
4	Acute encephalopathy (HP:0006846)	3.54826442
5	Congenital, generalized hypertrichosis (HP:0004540)	3.53719954
6	Mitochondrial inheritance (HP:0001427)	3.52271851
7	Pancreatic cysts (HP:0001737)	3.45488043
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.27038244
9	Progressive macrocephaly (HP:0004481)	3.25291225
10	Increased hepatocellular lipid droplets (HP:0006565)	3.23869466
11	Increased CSF lactate (HP:0002490)	3.20878482
12	Pancreatic fibrosis (HP:0100732)	3.14124930
13	Lipid accumulation in hepatocytes (HP:0006561)	3.09972850
14	Congenital stationary night blindness (HP:0007642)	2.99220910
15	True hermaphroditism (HP:0010459)	2.98683219
16	Abnormality of cells of the erythroid lineage (HP:0012130)	2.89274715
17	Stomatitis (HP:0010280)	2.87562889
18	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86966908
19	Hepatocellular necrosis (HP:0001404)	2.85621689
20	Pendular nystagmus (HP:0012043)	2.85396372
21	Hyperglycinemia (HP:0002154)	2.85261402
22	Abnormality of B cell number (HP:0010975)	2.82026470
23	Cerebral edema (HP:0002181)	2.80797301
24	Increased IgM level (HP:0003496)	2.77607576
25	Reticulocytopenia (HP:0001896)	2.72423824
26	Abnormal biliary tract physiology (HP:0012439)	2.71688430
27	Bile duct proliferation (HP:0001408)	2.71688430
28	Glycosuria (HP:0003076)	2.69332984
29	Abnormality of urine glucose concentration (HP:0011016)	2.69332984
30	Abnormality of midbrain morphology (HP:0002418)	2.66976234
31	Molar tooth sign on MRI (HP:0002419)	2.66976234
32	Abolished electroretinogram (ERG) (HP:0000550)	2.65583252
33	Methylmalonic aciduria (HP:0012120)	2.64792875
34	Hepatic necrosis (HP:0002605)	2.61716085
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.61317763
36	Nephronophthisis (HP:0000090)	2.53821752
37	B lymphocytopenia (HP:0010976)	2.53016866
38	Abnormal number of erythroid precursors (HP:0012131)	2.48464780
39	Confusion (HP:0001289)	2.46905815
40	Decreased central vision (HP:0007663)	2.46296209
41	Methylmalonic acidemia (HP:0002912)	2.43558365
42	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.41325416
43	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.37437871
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.37105364
45	Lethargy (HP:0001254)	2.36769329
46	Type II lissencephaly (HP:0007260)	2.34500103
47	Increased serum lactate (HP:0002151)	2.33954446
48	Optic disc pallor (HP:0000543)	2.32960223
49	Abnormality of glycine metabolism (HP:0010895)	2.31934824
50	Abnormality of serine family amino acid metabolism (HP:0010894)	2.31934824
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.30895170
52	Increased intramyocellular lipid droplets (HP:0012240)	2.30568211
53	Renal Fanconi syndrome (HP:0001994)	2.29321706
54	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.27877793
55	Macrocytic anemia (HP:0001972)	2.25440476
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24901197
57	Absent thumb (HP:0009777)	2.24745333
58	Exertional dyspnea (HP:0002875)	2.24708285
59	Lactic acidosis (HP:0003128)	2.23996733
60	Increased corneal curvature (HP:0100692)	2.23025684
61	Keratoconus (HP:0000563)	2.23025684
62	Hyperglycinuria (HP:0003108)	2.21329112
63	Hypoplasia of the uterus (HP:0000013)	2.19167655
64	Abnormality of the prostate (HP:0008775)	2.17791785
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17466880
66	Abnormality of T cell physiology (HP:0011840)	2.16228372
67	Abnormality of the renal medulla (HP:0100957)	2.15700417
68	Cystic liver disease (HP:0006706)	2.14740493
69	Pancytopenia (HP:0001876)	2.13605791
70	Sclerocornea (HP:0000647)	2.12265793
71	Thyroiditis (HP:0100646)	2.10318328
72	Eosinophilia (HP:0001880)	2.09119328
73	Abnormality of vitamin B metabolism (HP:0004340)	2.07886595
74	Abnormality of the renal cortex (HP:0011035)	2.04890776
75	Severe combined immunodeficiency (HP:0004430)	2.03438254
76	Increased muscle lipid content (HP:0009058)	2.01468820
77	Alveolar cell carcinoma (HP:0006519)	1.99870521
78	Panhypogammaglobulinemia (HP:0003139)	1.99244692
79	Dicarboxylic aciduria (HP:0003215)	1.95582659
80	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.95582659
81	Abnormality of eosinophils (HP:0001879)	1.94431637
82	Hyperphosphaturia (HP:0003109)	1.93191989
83	IgM deficiency (HP:0002850)	1.92225089
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91777772
85	Abnormality of serum amino acid levels (HP:0003112)	1.89992735
86	Septo-optic dysplasia (HP:0100842)	1.88566607
87	Metabolic alkalosis (HP:0200114)	1.87307544
88	Asplenia (HP:0001746)	1.84116991
89	Colon cancer (HP:0003003)	1.82166191
90	IgA deficiency (HP:0002720)	1.80255940
91	Polydipsia (HP:0001959)	1.80250149
92	Abnormal drinking behavior (HP:0030082)	1.80250149
93	Ketosis (HP:0001946)	1.79822824
94	Agammaglobulinemia (HP:0004432)	1.78839294
95	Attenuation of retinal blood vessels (HP:0007843)	1.77947882
96	Male pseudohermaphroditism (HP:0000037)	1.77625863
97	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.77000338
98	Tubular atrophy (HP:0000092)	1.76730248
99	Respiratory failure (HP:0002878)	1.73613559
100	Hypoproteinemia (HP:0003075)	1.73493750

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.75265929
2	TLK1	3.45291722
3	NUAK1	3.31480096
4	ACVR1B	2.88331956
5	ZAK	2.85099083
6	FRK	2.64337479
7	ADRBK2	2.62698836
8	VRK2	2.58068892
9	TXK	2.48387128
10	GRK1	2.36269130
11	WNK4	2.21933614
12	MAP4K2	2.13801929
13	BCKDK	1.83649724
14	EIF2AK3	1.77387564
15	PINK1	1.74477268
16	STK16	1.70701681
17	NEK1	1.68333089
18	KIT	1.64112055
19	OXSR1	1.49090243
20	GRK6	1.40307533
21	FES	1.38472505
22	TEC	1.38047676
23	DYRK2	1.34746008
24	NME1	1.33150349
25	MAPKAPK3	1.31849598
26	CDK19	1.31636149
27	STK39	1.28771804
28	VRK1	1.27613521
29	MST4	1.24337338
30	EIF2AK1	1.22687826
31	WNK3	1.21963597
32	MAP2K2	1.19280728
33	IKBKB	1.14640557
34	KDR	1.09448765
35	ITK	1.07155859
36	MAP4K1	1.05814496
37	RPS6KA5	0.98938266
38	SRPK1	0.96335144
39	MAP3K14	0.88351013
40	PHKG2	0.85824558
41	PHKG1	0.85824558
42	TNIK	0.85519683
43	PRKCQ	0.84443950
44	SYK	0.83559045
45	MKNK1	0.82000835
46	INSRR	0.79922491
47	TIE1	0.78475650
48	ADRBK1	0.77129303
49	LYN	0.74646289
50	IKBKE	0.74002525
51	MAPK13	0.73873773
52	MAPKAPK5	0.72637235
53	PIK3CA	0.72028177
54	MUSK	0.71859126
55	MAP2K6	0.71617476
56	EIF2AK2	0.71007682
57	CDC7	0.70784652
58	PLK3	0.70434778
59	MKNK2	0.68946012
60	NEK2	0.68809789
61	PLK2	0.68282031
62	LCK	0.66086731
63	BCR	0.65644565
64	BMPR1B	0.62711165
65	BTK	0.62533926
66	FLT3	0.60600512
67	TAF1	0.57364369
68	PRKCE	0.55855722
69	BUB1	0.55143293
70	TESK2	0.51830581
71	AURKB	0.51702514
72	PRKCG	0.51430729
73	PRKCA	0.51354288
74	CSF1R	0.51281588
75	NME2	0.50768886
76	SIK2	0.49629183
77	PLK4	0.49247484
78	PRKCD	0.48216380
79	MAP3K12	0.47919421
80	PLK1	0.46722100
81	CAMKK2	0.46590312
82	CSNK2A1	0.46538447
83	PDK2	0.46521738
84	GRK5	0.45025065
85	PRKACA	0.43281863
86	TNK2	0.42646999
87	PRKCI	0.41834559
88	JAK3	0.41338914
89	CSNK1G2	0.40672194
90	CSNK2A2	0.40603736
91	MATK	0.40530288
92	PRKCH	0.39710433
93	PASK	0.39611206
94	PIM1	0.39335851
95	RPS6KA6	0.39267186
96	IGF1R	0.38901365
97	RPS6KA4	0.37914955
98	CSNK1A1	0.37414033
99	MYLK	0.35264069
100	PRKACG	0.33653355

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.04928303
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.42405421
3	Allograft rejection_Homo sapiens_hsa05330	3.10504054
4	Ribosome_Homo sapiens_hsa03010	3.05639090
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.94712714
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.92647671
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77986844
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.44279498
9	Proteasome_Homo sapiens_hsa03050	2.35990065
10	Parkinsons disease_Homo sapiens_hsa05012	2.31747884
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10863589
12	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.10133467
13	Fat digestion and absorption_Homo sapiens_hsa04975	2.07685468
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81236679
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.80302757
16	RNA polymerase_Homo sapiens_hsa03020	1.77401638
17	Sulfur metabolism_Homo sapiens_hsa00920	1.75963252
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73476492
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.65163985
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.64472884
21	Alzheimers disease_Homo sapiens_hsa05010	1.52282044
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44927869
23	Caffeine metabolism_Homo sapiens_hsa00232	1.44519846
24	Huntingtons disease_Homo sapiens_hsa05016	1.40216837
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.39834836
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37353413
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.34143697
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30811737
29	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.30487971
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.29834367
31	One carbon pool by folate_Homo sapiens_hsa00670	1.29265362
32	Protein export_Homo sapiens_hsa03060	1.28636046
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.23100042
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20818521
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20464738
36	Phototransduction_Homo sapiens_hsa04744	1.18618434
37	Homologous recombination_Homo sapiens_hsa03440	1.15793017
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14967768
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.12516709
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11414867
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10879257
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08520555
43	RNA degradation_Homo sapiens_hsa03018	1.06468371
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.05490881
45	Retinol metabolism_Homo sapiens_hsa00830	1.05090656
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98035791
47	Sulfur relay system_Homo sapiens_hsa04122	0.97811329
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97042113
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.92308932
50	Propanoate metabolism_Homo sapiens_hsa00640	0.91553233
51	Viral myocarditis_Homo sapiens_hsa05416	0.90683615
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88015478
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87055300
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86425986
55	Butanoate metabolism_Homo sapiens_hsa00650	0.85078313
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.80739590
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80724247
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79661850
59	Peroxisome_Homo sapiens_hsa04146	0.77338838
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75964937
61	Purine metabolism_Homo sapiens_hsa00230	0.75444842
62	Basal transcription factors_Homo sapiens_hsa03022	0.75230382
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73962611
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68763977
65	Mineral absorption_Homo sapiens_hsa04978	0.68695550
66	Mismatch repair_Homo sapiens_hsa03430	0.68444875
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68187297
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67508870
69	Glutathione metabolism_Homo sapiens_hsa00480	0.67292662
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65046503
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64708800
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64310191
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63845501
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62112037
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61983657
76	Base excision repair_Homo sapiens_hsa03410	0.60147949
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58405831
78	Metabolic pathways_Homo sapiens_hsa01100	0.54464232
79	Fatty acid degradation_Homo sapiens_hsa00071	0.50659290
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48954680
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48079496
82	Leishmaniasis_Homo sapiens_hsa05140	0.46156636
83	Spliceosome_Homo sapiens_hsa03040	0.45709167
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45602458
85	Arginine biosynthesis_Homo sapiens_hsa00220	0.43570372
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.43364081
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43020643
88	Histidine metabolism_Homo sapiens_hsa00340	0.41818641
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40516054
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39300460
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.38055496
92	Renin-angiotensin system_Homo sapiens_hsa04614	0.37981861
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34406971
94	DNA replication_Homo sapiens_hsa03030	0.31560905
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30501856
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.28831141
97	Herpes simplex infection_Homo sapiens_hsa05168	0.27838283
98	Olfactory transduction_Homo sapiens_hsa04740	0.25609827
99	RNA transport_Homo sapiens_hsa03013	0.25458819
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24943218

RPL7P48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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