RPL7P49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.13158160
2rRNA catabolic process (GO:0016075)4.78396633
3ncRNA catabolic process (GO:0034661)4.05900527
4detection of light stimulus involved in sensory perception (GO:0050962)3.81674910
5detection of light stimulus involved in visual perception (GO:0050908)3.81674910
6kynurenine metabolic process (GO:0070189)3.80403530
7regulation of mitotic spindle checkpoint (GO:1903504)3.79528267
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79528267
9cellular response to ATP (GO:0071318)3.74160786
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.71929741
11NADH dehydrogenase complex assembly (GO:0010257)3.71929741
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71929741
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70017384
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70017384
15protein neddylation (GO:0045116)3.67054934
16protein complex biogenesis (GO:0070271)3.64933480
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61777974
18mannosylation (GO:0097502)3.59707263
19negative regulation of transcription regulatory region DNA binding (GO:2000678)3.57784507
20neural tube formation (GO:0001841)3.57548424
21behavioral response to nicotine (GO:0035095)3.56894570
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44750276
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42874884
24L-fucose catabolic process (GO:0042355)3.37873680
25fucose catabolic process (GO:0019317)3.37873680
26L-fucose metabolic process (GO:0042354)3.37873680
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37275000
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35563836
29protein K63-linked deubiquitination (GO:0070536)3.35050611
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.34773689
31termination of RNA polymerase III transcription (GO:0006386)3.34773689
32water-soluble vitamin biosynthetic process (GO:0042364)3.34588456
33tryptophan catabolic process (GO:0006569)3.32463459
34indole-containing compound catabolic process (GO:0042436)3.32463459
35indolalkylamine catabolic process (GO:0046218)3.32463459
36centriole replication (GO:0007099)3.30097748
37mitochondrial respiratory chain complex assembly (GO:0033108)3.27195068
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26730451
39resolution of meiotic recombination intermediates (GO:0000712)3.22506036
40ATP synthesis coupled proton transport (GO:0015986)3.16315212
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16315212
42base-excision repair, AP site formation (GO:0006285)3.12587904
43ribosomal small subunit assembly (GO:0000028)3.11882669
44indolalkylamine metabolic process (GO:0006586)3.11612308
45response to pheromone (GO:0019236)3.10458350
46tryptophan metabolic process (GO:0006568)3.08147088
47DNA deamination (GO:0045006)3.07270360
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03350012
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.01152931
50lactate metabolic process (GO:0006089)2.99345692
51DNA replication checkpoint (GO:0000076)2.99233818
52monoubiquitinated protein deubiquitination (GO:0035520)2.97540669
53replication fork processing (GO:0031297)2.97049753
54kidney morphogenesis (GO:0060993)2.95679293
55establishment of protein localization to mitochondrial membrane (GO:0090151)2.94941949
56electron transport chain (GO:0022900)2.94519564
57maturation of 5.8S rRNA (GO:0000460)2.93037047
58transcription elongation from RNA polymerase I promoter (GO:0006362)2.93030177
59dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86883487
60respiratory electron transport chain (GO:0022904)2.86670052
61cell wall macromolecule catabolic process (GO:0016998)2.86249337
62positive regulation of oligodendrocyte differentiation (GO:0048714)2.84378611
63regulation of cilium movement (GO:0003352)2.78138883
64regulation of triglyceride catabolic process (GO:0010896)2.75712886
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.75261656
66negative regulation of telomere maintenance (GO:0032205)2.74024713
67benzene-containing compound metabolic process (GO:0042537)2.72458356
68synapsis (GO:0007129)2.71301215
69tRNA processing (GO:0008033)2.70442301
70pyrimidine nucleobase catabolic process (GO:0006208)2.69880832
71recombinational repair (GO:0000725)2.69424864
72regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.69366159
73double-strand break repair via homologous recombination (GO:0000724)2.67182376
74histone mRNA metabolic process (GO:0008334)2.67075405
75respiratory chain complex IV assembly (GO:0008535)2.66250312
76ribosomal large subunit biogenesis (GO:0042273)2.65826990
77protein heterotetramerization (GO:0051290)2.65254446
78serotonin receptor signaling pathway (GO:0007210)2.63987841
79DNA double-strand break processing (GO:0000729)2.61203454
80rRNA modification (GO:0000154)2.58101379
81chromatin remodeling at centromere (GO:0031055)2.57495003
82hepatocyte apoptotic process (GO:0097284)2.56450356
83keratinocyte development (GO:0003334)2.52597753
84cell proliferation in forebrain (GO:0021846)2.50430414
85transcription from RNA polymerase III promoter (GO:0006383)2.50392593
86isoprenoid biosynthetic process (GO:0008299)2.50352292
87rRNA methylation (GO:0031167)2.48565190
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48525165
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48525165
90isotype switching (GO:0045190)2.48525165
91centriole assembly (GO:0098534)2.48145676
92cell wall macromolecule metabolic process (GO:0044036)2.46591108
93RNA phosphodiester bond hydrolysis (GO:0090501)2.46480781
94cytochrome complex assembly (GO:0017004)2.45839600
95microtubule depolymerization (GO:0007019)2.43946321
96intraciliary transport (GO:0042073)2.43782901
97termination of RNA polymerase I transcription (GO:0006363)2.41453475
98CENP-A containing nucleosome assembly (GO:0034080)2.40764500
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.40732597
100histone exchange (GO:0043486)2.40574992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.89282795
2ZNF274_21170338_ChIP-Seq_K562_Hela4.00256357
3VDR_22108803_ChIP-Seq_LS180_Human3.54764162
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50397197
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16290507
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.06819284
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76094188
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.61050226
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54631370
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.38749373
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35956223
12ELK1_19687146_ChIP-ChIP_HELA_Human2.34283455
13EWS_26573619_Chip-Seq_HEK293_Human2.31539341
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29143924
15FUS_26573619_Chip-Seq_HEK293_Human2.27790577
16TAF15_26573619_Chip-Seq_HEK293_Human2.21363910
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07526131
18P300_19829295_ChIP-Seq_ESCs_Human2.03698084
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.00398848
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97696556
21IGF1R_20145208_ChIP-Seq_DFB_Human1.92736394
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84649841
23VDR_23849224_ChIP-Seq_CD4+_Human1.80376294
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79246729
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77631466
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.70741611
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70513736
28EZH2_22144423_ChIP-Seq_EOC_Human1.67744051
29GBX2_23144817_ChIP-Seq_PC3_Human1.66313389
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65292507
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63723988
32ER_23166858_ChIP-Seq_MCF-7_Human1.63608300
33FOXP3_21729870_ChIP-Seq_TREG_Human1.58168005
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58154783
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57978440
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54606018
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52769957
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.52628874
39MYC_18940864_ChIP-ChIP_HL60_Human1.44737138
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43874687
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42429494
42IRF1_19129219_ChIP-ChIP_H3396_Human1.40971043
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40662631
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40516547
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40298246
46BCAT_22108803_ChIP-Seq_LS180_Human1.37764394
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36603935
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.36241148
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33145501
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32770495
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.32688352
52TCF4_22108803_ChIP-Seq_LS180_Human1.32677056
53CBP_20019798_ChIP-Seq_JUKART_Human1.32006363
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32006363
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28998929
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28157145
57TP53_22573176_ChIP-Seq_HFKS_Human1.26886474
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25916095
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25236623
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20625278
61NANOG_19829295_ChIP-Seq_ESCs_Human1.18172499
62SOX2_19829295_ChIP-Seq_ESCs_Human1.18172499
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17129384
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16457004
65AR_20517297_ChIP-Seq_VCAP_Human1.16232205
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.15289776
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.15000704
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12552195
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11402598
70NCOR_22424771_ChIP-Seq_293T_Human1.11058849
71P53_22387025_ChIP-Seq_ESCs_Mouse1.08331915
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06291834
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.06291834
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.05887849
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03401194
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.03178821
77RNF2_27304074_Chip-Seq_NSC_Mouse1.02855322
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02780901
79HOXB7_26014856_ChIP-Seq_BT474_Human1.02700409
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01844333
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.01297997
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01030818
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00295035
84P300_18555785_Chip-Seq_ESCs_Mouse0.99763742
85STAT3_23295773_ChIP-Seq_U87_Human0.99546566
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.98338540
87AR_25329375_ChIP-Seq_VCAP_Human0.97981004
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.97580953
89SOX2_18555785_Chip-Seq_ESCs_Mouse0.97152642
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96651818
91NMYC_18555785_Chip-Seq_ESCs_Mouse0.95196263
92TCF4_23295773_ChIP-Seq_U87_Human0.94796637
93RUNX2_22187159_ChIP-Seq_PCA_Human0.94631422
94SMAD4_21799915_ChIP-Seq_A2780_Human0.94627784
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94535244
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94442612
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.94322370
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.93696742
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.92928234
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92807518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.83321674
2MP0003787_abnormal_imprinting3.64361262
3MP0005646_abnormal_pituitary_gland3.08051009
4MP0008872_abnormal_physiological_respon2.89267283
5MP0006292_abnormal_olfactory_placode2.69844273
6MP0004142_abnormal_muscle_tone2.62540475
7MP0002102_abnormal_ear_morphology2.61932360
8MP0000372_irregular_coat_pigmentation2.44744220
9MP0002837_dystrophic_cardiac_calcinosis2.34912733
10MP0004885_abnormal_endolymph2.22360495
11MP0008875_abnormal_xenobiotic_pharmacok2.11888655
12MP0001529_abnormal_vocalization2.07441693
13MP0005551_abnormal_eye_electrophysiolog2.06384898
14MP0001485_abnormal_pinna_reflex2.04950335
15MP0002163_abnormal_gland_morphology2.04735500
16MP0006072_abnormal_retinal_apoptosis2.03438702
17MP0008058_abnormal_DNA_repair2.01503228
18MP0008789_abnormal_olfactory_epithelium1.95686769
19MP0003195_calcinosis1.92347219
20MP0002938_white_spotting1.81434417
21MP0009379_abnormal_foot_pigmentation1.79381795
22MP0005671_abnormal_response_to1.77688197
23MP0003567_abnormal_fetal_cardiomyocyte1.77583976
24MP0004742_abnormal_vestibular_system1.73848410
25MP0002736_abnormal_nociception_after1.69693855
26MP0003890_abnormal_embryonic-extraembry1.60991764
27MP0008995_early_reproductive_senescence1.59032231
28MP0009697_abnormal_copulation1.53821912
29MP0003718_maternal_effect1.52486983
30MP0005379_endocrine/exocrine_gland_phen1.51971270
31MP0003693_abnormal_embryo_hatching1.51803162
32MP0010094_abnormal_chromosome_stability1.47580111
33MP0001968_abnormal_touch/_nociception1.41857568
34MP0003646_muscle_fatigue1.40700335
35MP0000569_abnormal_digit_pigmentation1.38817950
36MP0002234_abnormal_pharynx_morphology1.37378463
37MP0004147_increased_porphyrin_level1.36135168
38MP0003786_premature_aging1.36129433
39MP0000516_abnormal_urinary_system1.35578695
40MP0005367_renal/urinary_system_phenotyp1.35578695
41MP0008007_abnormal_cellular_replicative1.30714293
42MP0000631_abnormal_neuroendocrine_gland1.29771782
43MP0005410_abnormal_fertilization1.29138876
44MP0005389_reproductive_system_phenotype1.28404604
45MP0003121_genomic_imprinting1.27751181
46MP0005253_abnormal_eye_physiology1.27699879
47MP0005084_abnormal_gallbladder_morpholo1.27315862
48MP0001486_abnormal_startle_reflex1.24232944
49MP0001919_abnormal_reproductive_system1.22575668
50MP0005499_abnormal_olfactory_system1.21068140
51MP0005394_taste/olfaction_phenotype1.21068140
52MP0004381_abnormal_hair_follicle1.20726509
53MP0002653_abnormal_ependyma_morphology1.14930718
54MP0002160_abnormal_reproductive_system1.12807327
55MP0009745_abnormal_behavioral_response1.10109053
56MP0001986_abnormal_taste_sensitivity1.09834715
57MP0002876_abnormal_thyroid_physiology1.06686972
58MP0000427_abnormal_hair_cycle1.06329004
59MP0001293_anophthalmia1.05006537
60MP0001502_abnormal_circadian_rhythm1.01042613
61MP0002272_abnormal_nervous_system0.99736715
62MP0000049_abnormal_middle_ear0.94725234
63MP0001929_abnormal_gametogenesis0.94350184
64MP0006276_abnormal_autonomic_nervous0.93645853
65MP0002735_abnormal_chemical_nociception0.90927477
66MP0005195_abnormal_posterior_eye0.90768313
67MP0008775_abnormal_heart_ventricle0.90268960
68MP0003137_abnormal_impulse_conducting0.89762579
69MP0002210_abnormal_sex_determination0.89370129
70MP0001440_abnormal_grooming_behavior0.87650096
71MP0001963_abnormal_hearing_physiology0.86416553
72MP0000653_abnormal_sex_gland0.83079538
73MP0001145_abnormal_male_reproductive0.81587019
74MP0001501_abnormal_sleep_pattern0.80315935
75MP0002752_abnormal_somatic_nervous0.79551290
76MP0006035_abnormal_mitochondrial_morpho0.78261334
77MP0004215_abnormal_myocardial_fiber0.77869084
78MP0004957_abnormal_blastocyst_morpholog0.77476702
79MP0002572_abnormal_emotion/affect_behav0.76247063
80MP0002557_abnormal_social/conspecific_i0.76007712
81MP0003011_delayed_dark_adaptation0.75245036
82MP0005174_abnormal_tail_pigmentation0.74327740
83MP0003638_abnormal_response/metabolism_0.72836349
84MP0004145_abnormal_muscle_electrophysio0.71892238
85MP0005636_abnormal_mineral_homeostasis0.71778119
86MP0000778_abnormal_nervous_system0.70192603
87MP0002067_abnormal_sensory_capabilities0.69009002
88MP0002184_abnormal_innervation0.68760799
89MP0003136_yellow_coat_color0.68717641
90MP0000647_abnormal_sebaceous_gland0.68341896
91MP0001346_abnormal_lacrimal_gland0.67253006
92MP0004924_abnormal_behavior0.66718286
93MP0005386_behavior/neurological_phenoty0.66718286
94MP0002638_abnormal_pupillary_reflex0.66292101
95MP0003698_abnormal_male_reproductive0.65107843
96MP0003806_abnormal_nucleotide_metabolis0.64604082
97MP0009764_decreased_sensitivity_to0.64246658
98MP0010386_abnormal_urinary_bladder0.63611546
99MP0001905_abnormal_dopamine_level0.61397212
100MP0001119_abnormal_female_reproductive0.61325998

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.13787558
2Congenital, generalized hypertrichosis (HP:0004540)3.92698746
3Pancreatic fibrosis (HP:0100732)3.85668228
4True hermaphroditism (HP:0010459)3.52072750
5Acute necrotizing encephalopathy (HP:0006965)3.33655291
6Abnormality of the pons (HP:0007361)3.29925141
7Hypoproteinemia (HP:0003075)3.24049122
8Molar tooth sign on MRI (HP:0002419)3.19608912
9Abnormality of midbrain morphology (HP:0002418)3.19608912
10Acute encephalopathy (HP:0006846)3.04837369
11Abnormality of the renal cortex (HP:0011035)3.00451124
12Hypoplasia of the pons (HP:0012110)2.97691832
13Abolished electroretinogram (ERG) (HP:0000550)2.96869994
14Abnormal mitochondria in muscle tissue (HP:0008316)2.91787577
15Chronic hepatic failure (HP:0100626)2.90532250
16Methylmalonic acidemia (HP:0002912)2.88183807
17Abnormality of DNA repair (HP:0003254)2.87661152
18Progressive macrocephaly (HP:0004481)2.86829369
193-Methylglutaconic aciduria (HP:0003535)2.77583706
20Abnormality of the renal medulla (HP:0100957)2.75773056
21Reticulocytopenia (HP:0001896)2.73832839
22Nephronophthisis (HP:0000090)2.72864557
23Pendular nystagmus (HP:0012043)2.67936596
24Intestinal atresia (HP:0011100)2.66246019
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65922871
26Type I transferrin isoform profile (HP:0003642)2.63404302
27Mitochondrial inheritance (HP:0001427)2.62241576
28Congenital stationary night blindness (HP:0007642)2.61822391
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57221995
30Colon cancer (HP:0003003)2.52947705
31Cystic liver disease (HP:0006706)2.52455129
32Sclerocornea (HP:0000647)2.46803462
33Methylmalonic aciduria (HP:0012120)2.46783194
34Attenuation of retinal blood vessels (HP:0007843)2.43548590
35Reduced antithrombin III activity (HP:0001976)2.43303059
36Hyperglycinemia (HP:0002154)2.39672968
37Medial flaring of the eyebrow (HP:0010747)2.38605146
38Hepatocellular necrosis (HP:0001404)2.38107136
39Increased CSF lactate (HP:0002490)2.36903802
40Dyschromatopsia (HP:0007641)2.35086431
41Decreased central vision (HP:0007663)2.31847988
42Carpal bone hypoplasia (HP:0001498)2.31652821
43Abnormal rod and cone electroretinograms (HP:0008323)2.23800673
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.21977192
45Postaxial foot polydactyly (HP:0001830)2.21793507
46Bifid tongue (HP:0010297)2.17728500
47Progressive inability to walk (HP:0002505)2.16599705
48Absent thumb (HP:0009777)2.15806141
49Poor coordination (HP:0002370)2.14815612
50Abnormality of the ileum (HP:0001549)2.14426682
51Optic disc pallor (HP:0000543)2.11392296
52Gastrointestinal atresia (HP:0002589)2.10627758
53Macular degeneration (HP:0000608)2.07745022
54Hyperventilation (HP:0002883)2.05025098
55Hepatic necrosis (HP:0002605)2.04429506
56Chorioretinal atrophy (HP:0000533)2.02317336
57Nephrogenic diabetes insipidus (HP:0009806)2.01842877
58Delayed CNS myelination (HP:0002188)2.01382486
59Pancreatic islet-cell hyperplasia (HP:0004510)2.00739293
60Meckel diverticulum (HP:0002245)1.99792932
61Type II lissencephaly (HP:0007260)1.99510288
62Abnormal hair whorl (HP:0010721)1.97584427
63Aplasia/Hypoplasia of the uvula (HP:0010293)1.96666655
64Anophthalmia (HP:0000528)1.95427972
65Hypothermia (HP:0002045)1.93695262
66Stomatitis (HP:0010280)1.93644255
67Genital tract atresia (HP:0001827)1.93532098
68Polyuria (HP:0000103)1.90566991
69Stomach cancer (HP:0012126)1.89912659
70Congenital hepatic fibrosis (HP:0002612)1.88080775
71Gait imbalance (HP:0002141)1.87578293
72Male pseudohermaphroditism (HP:0000037)1.87333632
73Congenital primary aphakia (HP:0007707)1.87282432
74Vaginal atresia (HP:0000148)1.83032237
75Meningocele (HP:0002435)1.82808709
76Abnormality of the proximal phalanges of the hand (HP:0009834)1.82378418
77Bile duct proliferation (HP:0001408)1.81359530
78Abnormal biliary tract physiology (HP:0012439)1.81359530
79Polydipsia (HP:0001959)1.81198689
80Abnormal drinking behavior (HP:0030082)1.81198689
81Abnormality of the renal collecting system (HP:0004742)1.81108085
82Renal cortical cysts (HP:0000803)1.80600449
83Cerebral edema (HP:0002181)1.79416020
84Duplicated collecting system (HP:0000081)1.79296264
85Inability to walk (HP:0002540)1.78477495
86Volvulus (HP:0002580)1.77258233
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72434789
88Abnormal protein N-linked glycosylation (HP:0012347)1.72434789
89Abnormal protein glycosylation (HP:0012346)1.72434789
90Abnormal glycosylation (HP:0012345)1.72434789
91Constricted visual fields (HP:0001133)1.71445786
92Leukodystrophy (HP:0002415)1.71202472
93Increased corneal curvature (HP:0100692)1.68944206
94Keratoconus (HP:0000563)1.68944206
95Rectal fistula (HP:0100590)1.68913447
96Rectovaginal fistula (HP:0000143)1.68913447
97Preaxial hand polydactyly (HP:0001177)1.68191671
98Lipid accumulation in hepatocytes (HP:0006561)1.68146232
99Abnormality of glycine metabolism (HP:0010895)1.68035937
100Abnormality of serine family amino acid metabolism (HP:0010894)1.68035937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.88157977
2FRK3.41481570
3BRSK23.25784087
4MST42.98786671
5ZAK2.85796955
6EIF2AK32.49460212
7WEE12.39288758
8WNK32.16685993
9EPHA32.05025688
10MAP4K22.04000067
11STK162.00834280
12MKNK21.93979825
13ADRBK21.90445982
14TXK1.90063213
15MKNK11.83511645
16TRIM281.79141293
17NUAK11.77870598
18GRK11.74253451
19TIE11.61753733
20TSSK61.53861464
21PIK3CA1.53567806
22CDC71.49149916
23TAF11.42188457
24BMPR1B1.40269926
25PINK11.39629067
26VRK21.37395598
27CAMKK21.37115347
28PAK31.35936039
29STK38L1.34628364
30TLK11.33933963
31SRPK11.30508905
32PIK3CG1.27038178
33PLK31.22862246
34TNIK1.18192474
35OXSR11.17953149
36FER1.15872577
37MAPK131.14424311
38CASK1.11213307
39WNK41.08348130
40BRSK11.07222424
41DYRK21.03474607
42NME10.97488956
43IKBKE0.93051209
44PLK40.90613396
45BUB10.83481846
46TEC0.76540651
47PRKCI0.72628994
48PLK10.72589751
49VRK10.71920209
50IKBKB0.71727826
51ACVR1B0.70916775
52PRKCQ0.69465302
53CDK190.67758665
54MAPKAPK50.67608236
55TAOK30.65815050
56PRKCE0.65691125
57MAP3K120.65430524
58TNK20.64716055
59NEK90.62832743
60ITK0.61456765
61AKT30.60407039
62FLT30.58721354
63DAPK20.58433345
64NLK0.57246308
65AURKB0.56876455
66PLK20.56535284
67MARK30.54949287
68PIM10.51420105
69PKN10.49691844
70ADRBK10.48450590
71STK30.48415994
72RPS6KA50.47978256
73PASK0.45132691
74FGFR10.44603827
75UHMK10.43977793
76CAMK10.43896415
77ATM0.43353880
78ATR0.43058555
79BCR0.42483454
80IGF1R0.42210844
81IRAK10.42171726
82CAMK40.42051336
83STK110.41966733
84LYN0.41580122
85EIF2AK20.38145633
86STK390.37753460
87CSNK2A20.37527043
88MARK10.37435100
89CSNK1G20.37400754
90PRKCG0.37255268
91PRKACA0.36750598
92ERBB20.36478881
93PNCK0.36175669
94TYRO30.35901044
95FES0.35701905
96TGFBR10.34396966
97MAP2K60.33504697
98NEK60.32818337
99EIF2AK10.32603457
100PHKG20.32401463

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.18193709
2Oxidative phosphorylation_Homo sapiens_hsa001903.06192553
3Protein export_Homo sapiens_hsa030602.77856765
4Homologous recombination_Homo sapiens_hsa034402.72276190
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61268904
6Ribosome_Homo sapiens_hsa030102.58802952
7RNA polymerase_Homo sapiens_hsa030202.49659962
8Parkinsons disease_Homo sapiens_hsa050122.39606929
9RNA degradation_Homo sapiens_hsa030182.31360870
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15627868
11Linoleic acid metabolism_Homo sapiens_hsa005912.12811514
12Fanconi anemia pathway_Homo sapiens_hsa034602.03765397
13Asthma_Homo sapiens_hsa053102.02171767
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99580612
15Nucleotide excision repair_Homo sapiens_hsa034201.91867003
16Phototransduction_Homo sapiens_hsa047441.86580791
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78726319
18Huntingtons disease_Homo sapiens_hsa050161.72037264
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70076804
20Basal transcription factors_Homo sapiens_hsa030221.65496119
21Mismatch repair_Homo sapiens_hsa034301.59089534
22Tryptophan metabolism_Homo sapiens_hsa003801.56329301
23Alzheimers disease_Homo sapiens_hsa050101.50151383
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.49941320
25Autoimmune thyroid disease_Homo sapiens_hsa053201.48884389
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46279819
27Non-homologous end-joining_Homo sapiens_hsa034501.45468286
28Allograft rejection_Homo sapiens_hsa053301.44149455
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42002613
30Nitrogen metabolism_Homo sapiens_hsa009101.35935932
31Base excision repair_Homo sapiens_hsa034101.35318217
32One carbon pool by folate_Homo sapiens_hsa006701.33382910
33Cardiac muscle contraction_Homo sapiens_hsa042601.31490525
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25951195
35Propanoate metabolism_Homo sapiens_hsa006401.24569510
36Caffeine metabolism_Homo sapiens_hsa002321.24201292
37Graft-versus-host disease_Homo sapiens_hsa053321.22743327
38beta-Alanine metabolism_Homo sapiens_hsa004101.22370254
39RNA transport_Homo sapiens_hsa030131.19764793
40Spliceosome_Homo sapiens_hsa030401.19113539
41Ether lipid metabolism_Homo sapiens_hsa005651.16614872
42DNA replication_Homo sapiens_hsa030301.16413616
43Primary immunodeficiency_Homo sapiens_hsa053401.14755338
44Retinol metabolism_Homo sapiens_hsa008301.14152485
45Type I diabetes mellitus_Homo sapiens_hsa049401.10789413
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08516565
47Butanoate metabolism_Homo sapiens_hsa006501.07369037
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03783349
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02908900
50Chemical carcinogenesis_Homo sapiens_hsa052041.02139373
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00587394
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95576557
53Pyruvate metabolism_Homo sapiens_hsa006200.95524210
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93003810
55Arachidonic acid metabolism_Homo sapiens_hsa005900.91294061
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91252508
57Fatty acid degradation_Homo sapiens_hsa000710.90772721
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90307328
59Histidine metabolism_Homo sapiens_hsa003400.88630505
60Vitamin digestion and absorption_Homo sapiens_hsa049770.86301203
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83781857
62Pyrimidine metabolism_Homo sapiens_hsa002400.83553226
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82302724
64Fat digestion and absorption_Homo sapiens_hsa049750.78444308
65Nicotine addiction_Homo sapiens_hsa050330.75593967
66Olfactory transduction_Homo sapiens_hsa047400.74376380
67Steroid biosynthesis_Homo sapiens_hsa001000.74244348
68Purine metabolism_Homo sapiens_hsa002300.73302162
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.70984127
70Ovarian steroidogenesis_Homo sapiens_hsa049130.68061789
71Antigen processing and presentation_Homo sapiens_hsa046120.66150443
72Peroxisome_Homo sapiens_hsa041460.65186614
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.64069778
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63019029
75Rheumatoid arthritis_Homo sapiens_hsa053230.61470337
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59904181
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58887906
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57230144
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56824887
80Metabolic pathways_Homo sapiens_hsa011000.55318951
81Systemic lupus erythematosus_Homo sapiens_hsa053220.54802794
82Hematopoietic cell lineage_Homo sapiens_hsa046400.53817113
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47924002
84Glycerolipid metabolism_Homo sapiens_hsa005610.47907828
85Taste transduction_Homo sapiens_hsa047420.47077170
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46162057
87Circadian rhythm_Homo sapiens_hsa047100.42427991
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42348608
89Hedgehog signaling pathway_Homo sapiens_hsa043400.39509769
90mRNA surveillance pathway_Homo sapiens_hsa030150.36699456
91Lysine degradation_Homo sapiens_hsa003100.36305477
92Regulation of autophagy_Homo sapiens_hsa041400.33078270
93Cell cycle_Homo sapiens_hsa041100.30883470
94Arginine and proline metabolism_Homo sapiens_hsa003300.28074233
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.26388955
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25619307
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.25560025
98Morphine addiction_Homo sapiens_hsa050320.23771342
99Staphylococcus aureus infection_Homo sapiens_hsa051500.22842151
100N-Glycan biosynthesis_Homo sapiens_hsa005100.22240367

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