ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of skeletal muscle contraction (GO:0014819)	9.60468456
2	skeletal muscle tissue regeneration (GO:0043403)	9.47222984
3	muscle filament sliding (GO:0030049)	9.23383061
4	actin-myosin filament sliding (GO:0033275)	9.23383061
5	response to muscle activity (GO:0014850)	8.27200193
6	negative regulation of skeletal muscle tissue development (GO:0048642)	8.15682188
7	actin-mediated cell contraction (GO:0070252)	7.50682070
8	cellular response to dexamethasone stimulus (GO:0071549)	6.76013378
9	response to dexamethasone (GO:0071548)	6.22796419
10	response to activity (GO:0014823)	5.78018353
11	protein K6-linked ubiquitination (GO:0085020)	5.38263422
12	actin filament-based movement (GO:0030048)	5.11569439
13	striated muscle adaptation (GO:0014888)	4.96411070
14	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	4.73901180
15	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.64954686
16	ribosomal small subunit assembly (GO:0000028)	4.50577136
17	regulation of muscle hypertrophy (GO:0014743)	4.47441302
18	viral transcription (GO:0019083)	4.37021865
19	negative regulation of organelle assembly (GO:1902116)	4.33723663
20	DNA damage response, signal transduction resulting in transcription (GO:0042772)	4.30556209
21	protein trimerization (GO:0070206)	4.25353871
22	dosage compensation (GO:0007549)	4.18926536
23	translational termination (GO:0006415)	4.12628153
24	protein polyglutamylation (GO:0018095)	4.04808406
25	myotube cell development (GO:0014904)	4.03924922
26	response to testosterone (GO:0033574)	4.00452866
27	response to electrical stimulus (GO:0051602)	3.98881259
28	translational elongation (GO:0006414)	3.95704890
29	muscle adaptation (GO:0043500)	3.89059307
30	regulation of DNA methylation (GO:0044030)	3.83759292
31	skeletal muscle contraction (GO:0003009)	3.81059827
32	ribosomal small subunit biogenesis (GO:0042274)	3.75842771
33	negative regulation of striated muscle tissue development (GO:0045843)	3.74624781
34	negative regulation of muscle tissue development (GO:1901862)	3.73308818
35	muscle organ development (GO:0007517)	3.68888646
36	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.63756592
37	muscle structure development (GO:0061061)	3.62104971
38	cell proliferation in forebrain (GO:0021846)	3.60699051
39	negative regulation of muscle organ development (GO:0048635)	3.47668013
40	regulation of centriole replication (GO:0046599)	3.46178915
41	skeletal muscle fiber development (GO:0048741)	3.42792107
42	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.41625581
43	cellular response to glucocorticoid stimulus (GO:0071385)	3.40493017
44	protein neddylation (GO:0045116)	3.40042446
45	tissue regeneration (GO:0042246)	3.36756909
46	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.32126899
47	positive regulation of histone H3-K4 methylation (GO:0051571)	3.29606928
48	regulation of gene expression by genetic imprinting (GO:0006349)	3.27544090
49	protein targeting to ER (GO:0045047)	3.26383906
50	regulation of relaxation of muscle (GO:1901077)	3.25917300
51	cotranslational protein targeting to membrane (GO:0006613)	3.23785840
52	dendritic spine morphogenesis (GO:0060997)	3.20270749
53	cellular response to corticosteroid stimulus (GO:0071384)	3.13294451
54	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.11955376
55	dentate gyrus development (GO:0021542)	3.11903332
56	cellular protein complex disassembly (GO:0043624)	3.07060336
57	protein localization to endoplasmic reticulum (GO:0070972)	3.06931810
58	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.05485403
59	viral life cycle (GO:0019058)	3.02959042
60	cellular response to ketone (GO:1901655)	3.02620185
61	myoblast migration (GO:0051451)	2.98437112
62	muscle system process (GO:0003012)	2.97773808
63	heparin metabolic process (GO:0030202)	2.96966530
64	heparin biosynthetic process (GO:0030210)	2.96966530
65	muscle contraction (GO:0006936)	2.88957337
66	negative regulation of histone acetylation (GO:0035067)	2.88708709
67	genetic imprinting (GO:0071514)	2.87025531
68	response to inactivity (GO:0014854)	2.73652480
69	translational initiation (GO:0006413)	2.72735554
70	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.72473676
71	protein complex disassembly (GO:0043241)	2.70638058
72	negative regulation of fatty acid metabolic process (GO:0045922)	2.70033458
73	regulation of histone H3-K9 methylation (GO:0051570)	2.68949783
74	somite development (GO:0061053)	2.67345118
75	maturation of SSU-rRNA (GO:0030490)	2.65602354
76	radial glial cell differentiation (GO:0060019)	2.65440852
77	mesonephros development (GO:0001823)	2.62506460
78	viral genome replication (GO:0019079)	2.59113610
79	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.57597775
80	macromolecular complex disassembly (GO:0032984)	2.57421317
81	pattern specification involved in kidney development (GO:0061004)	2.52452344
82	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.51847711
83	heart field specification (GO:0003128)	2.49378618
84	secondary heart field specification (GO:0003139)	2.49378618
85	negative regulation of histone methylation (GO:0031061)	2.48966729
86	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.47745449
87	calcium ion import (GO:0070509)	2.47346792
88	nephron epithelium morphogenesis (GO:0072088)	2.43196894
89	nephron tubule morphogenesis (GO:0072078)	2.43196894
90	regulation of germinal center formation (GO:0002634)	2.42435537
91	cartilage morphogenesis (GO:0060536)	2.40311944
92	muscle fiber development (GO:0048747)	2.38347595
93	middle ear morphogenesis (GO:0042474)	2.37150908
94	lymphangiogenesis (GO:0001946)	2.36791791
95	positive regulation of gastrulation (GO:2000543)	2.36714364
96	response to gravity (GO:0009629)	14.9014935
97	skeletal muscle adaptation (GO:0043501)	12.0224802
98	striated muscle atrophy (GO:0014891)	11.7976573
99	muscle atrophy (GO:0014889)	10.6080633
100	negative regulation of muscle hypertrophy (GO:0014741)	10.5090271

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.14997184
2	VDR_22108803_ChIP-Seq_LS180_Human	8.00375671
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.25312612
4	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	5.02889068
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.60778396
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.84524925
7	TAF15_26573619_Chip-Seq_HEK293_Human	3.44919470
8	FUS_26573619_Chip-Seq_HEK293_Human	2.80930849
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.51692224
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.49353830
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.41681887
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.18874708
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.17755150
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00914645
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.93573123
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92441268
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82378310
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.82004891
19	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.76162242
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67633281
21	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.67511112
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.62875742
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.60299446
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.59685325
25	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.59014727
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58013306
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.55482412
28	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.54908759
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54008693
30	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.51303239
31	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.49623872
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47391231
33	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.45088435
34	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.44172585
35	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.44172585
36	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.43378038
37	RXR_22108803_ChIP-Seq_LS180_Human	1.39606045
38	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.38441924
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.38196872
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36523675
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32349932
42	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.30803620
43	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.30803620
44	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.30803620
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28683684
46	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.26256264
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25861492
48	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.21142968
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18674324
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18597766
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17963082
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.17248186
53	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.16743879
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15523072
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.15360196
56	P300_19829295_ChIP-Seq_ESCs_Human	1.13877385
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09022658
58	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.07140618
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.06278789
60	SOX9_26525672_Chip-Seq_HEART_Mouse	1.05907546
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05805778
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04587722
63	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00076627
64	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.00060018
65	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98087293
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97173358
67	KDM2B_26808549_Chip-Seq_REH_Human	0.97000306
68	MYC_19829295_ChIP-Seq_ESCs_Human	0.94933030
69	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94852367
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93966612
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92978607
72	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.92965583
73	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91499633
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.90403169
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89959763
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89426047
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.88408864
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87504689
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.86469060
80	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86364801
81	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.85336322
82	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.82737989
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.82530030
84	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.78538873
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.78460744
86	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.77231384
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.77012203
88	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.76618454
89	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.75399760
90	CBP_21632823_ChIP-Seq_H3396_Human	0.74269554
91	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.74178108
92	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.72725416
93	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.72520235
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.72386224
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.71555925
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.71173132
97	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.69647551
98	STAT3_23295773_ChIP-Seq_U87_Human	0.69551678
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.69174776
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.69174776

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	5.21249089
2	MP0000747_muscle_weakness	4.98583590
3	MP0002089_abnormal_postnatal_growth/wei	4.23128305
4	MP0003705_abnormal_hypodermis_morpholog	3.65203333
5	MP0004036_abnormal_muscle_relaxation	3.48058288
6	MP0000749_muscle_degeneration	3.14492451
7	MP0002269_muscular_atrophy	3.02401547
8	MP0000759_abnormal_skeletal_muscle	2.96206718
9	MP0005083_abnormal_biliary_tract	2.77443191
10	MP0000566_synostosis	2.61826842
11	MP0002106_abnormal_muscle_physiology	2.57307329
12	MP0009379_abnormal_foot_pigmentation	2.53848265
13	MP0005620_abnormal_muscle_contractility	2.35944897
14	MP0002108_abnormal_muscle_morphology	2.32171633
15	MP0003646_muscle_fatigue	2.23189965
16	MP0004087_abnormal_muscle_fiber	2.20656867
17	MP0006292_abnormal_olfactory_placode	2.19901526
18	MP0010030_abnormal_orbit_morphology	2.19321324
19	MP0003959_abnormal_lean_body	2.10540920
20	MP0002138_abnormal_hepatobiliary_system	2.10299638
21	MP0005369_muscle_phenotype	1.96627846
22	MP0000750_abnormal_muscle_regeneration	1.91617598
23	MP0001968_abnormal_touch/_nociception	1.85827092
24	MP0000372_irregular_coat_pigmentation	1.81772202
25	MP0008789_abnormal_olfactory_epithelium	1.81155112
26	MP0003937_abnormal_limbs/digits/tail_de	1.74143957
27	MP0000751_myopathy	1.71018497
28	MP0001879_abnormal_lymphatic_vessel	1.61706462
29	MP0000049_abnormal_middle_ear	1.61546797
30	MP0002736_abnormal_nociception_after	1.57375547
31	MP0009250_abnormal_appendicular_skeleto	1.49285050
32	MP0000733_abnormal_muscle_development	1.40798746
33	MP0002095_abnormal_skin_pigmentation	1.40219415
34	MP0004142_abnormal_muscle_tone	1.39995611
35	MP0002638_abnormal_pupillary_reflex	1.39086676
36	MP0002277_abnormal_respiratory_mucosa	1.38480432
37	MP0003880_abnormal_central_pattern	1.33483962
38	MP0003938_abnormal_ear_development	1.28870178
39	MP0003123_paternal_imprinting	1.28067179
40	MP0000427_abnormal_hair_cycle	1.26567923
41	MP0004885_abnormal_endolymph	1.26114876
42	MP0002653_abnormal_ependyma_morphology	1.25895235
43	MP0004134_abnormal_chest_morphology	1.23371684
44	MP0002837_dystrophic_cardiac_calcinosis	1.20604801
45	MP0002896_abnormal_bone_mineralization	1.18053008
46	MP0006072_abnormal_retinal_apoptosis	1.17583867
47	MP0004270_analgesia	1.11808933
48	MP0002160_abnormal_reproductive_system	1.04019958
49	MP0004043_abnormal_pH_regulation	1.01103784
50	MP0009780_abnormal_chondrocyte_physiolo	0.98512230
51	MP0003787_abnormal_imprinting	0.97293626
52	MP0004130_abnormal_muscle_cell	0.94051039
53	MP0001485_abnormal_pinna_reflex	0.92674105
54	MP0002184_abnormal_innervation	0.91713109
55	MP0005499_abnormal_olfactory_system	0.91598256
56	MP0005394_taste/olfaction_phenotype	0.91598256
57	MP0000778_abnormal_nervous_system	0.89088658
58	MP0004484_altered_response_of	0.88600922
59	MP0000631_abnormal_neuroendocrine_gland	0.87133934
60	MP0001293_anophthalmia	0.86722093
61	MP0002876_abnormal_thyroid_physiology	0.85303483
62	MP0003755_abnormal_palate_morphology	0.84865832
63	MP0003121_genomic_imprinting	0.83452143
64	MP0002109_abnormal_limb_morphology	0.80026689
65	MP0002272_abnormal_nervous_system	0.76463581
66	MP0003119_abnormal_digestive_system	0.76078529
67	MP0003136_yellow_coat_color	0.75904708
68	MP0001905_abnormal_dopamine_level	0.75541945
69	MP0003045_fibrosis	0.75294706
70	MP0003878_abnormal_ear_physiology	0.73067365
71	MP0005377_hearing/vestibular/ear_phenot	0.73067365
72	MP0000467_abnormal_esophagus_morphology	0.72338659
73	MP0004133_heterotaxia	0.71267558
74	MP0002733_abnormal_thermal_nociception	0.70695610
75	MP0002102_abnormal_ear_morphology	0.68731796
76	MP0002177_abnormal_outer_ear	0.68298765
77	MP0004084_abnormal_cardiac_muscle	0.67903419
78	MP0002282_abnormal_trachea_morphology	0.67752578
79	MP0003942_abnormal_urinary_system	0.67287265
80	MP0000762_abnormal_tongue_morphology	0.65928379
81	MP0002116_abnormal_craniofacial_bone	0.65663093
82	MP0002114_abnormal_axial_skeleton	0.65553905
83	MP0005389_reproductive_system_phenotype	0.64365231
84	MP0003936_abnormal_reproductive_system	0.63911018
85	MP0002233_abnormal_nose_morphology	0.63747070
86	MP0010368_abnormal_lymphatic_system	0.63130732
87	MP0008057_abnormal_DNA_replication	0.62669558
88	MP0003315_abnormal_perineum_morphology	0.62240812
89	MP0003950_abnormal_plasma_membrane	0.61822105
90	MP0002115_abnormal_skeleton_extremities	0.60225995
91	MP0002067_abnormal_sensory_capabilities	0.59748294
92	MP0002127_abnormal_cardiovascular_syste	0.59705582
93	MP0001486_abnormal_startle_reflex	0.57759722
94	MP0002928_abnormal_bile_duct	0.57492579
95	MP0002734_abnormal_mechanical_nocicepti	0.57090026
96	MP0005551_abnormal_eye_electrophysiolog	0.55505170
97	MP0009745_abnormal_behavioral_response	0.55386915
98	MP0002210_abnormal_sex_determination	0.55313591
99	MP0001963_abnormal_hearing_physiology	0.54545460
100	MP0008872_abnormal_physiological_respon	0.53751724

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	8.94844908
2	Distal arthrogryposis (HP:0005684)	6.77318868
3	Round ear (HP:0100830)	6.42733915
4	Mask-like facies (HP:0000298)	6.29723284
5	Exercise-induced myalgia (HP:0003738)	6.25436586
6	Nemaline bodies (HP:0003798)	6.21811736
7	Absent phalangeal crease (HP:0006109)	5.77395998
8	Calcaneovalgus deformity (HP:0001848)	5.59523524
9	Ulnar deviation of the wrist (HP:0003049)	5.52787565
10	Deformed tarsal bones (HP:0008119)	5.07307050
11	Muscle fiber inclusion bodies (HP:0100299)	4.96529528
12	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	4.87128626
13	Abnormal finger flexion creases (HP:0006143)	4.83415327
14	Hyperkalemia (HP:0002153)	4.66998237
15	Periorbital edema (HP:0100539)	4.63733024
16	Facial edema (HP:0000282)	4.43532842
17	Type 1 muscle fiber predominance (HP:0003803)	4.06122678
18	Myoglobinuria (HP:0002913)	3.29920780
19	Fibular aplasia (HP:0002990)	3.27315914
20	Myopathic facies (HP:0002058)	3.11320938
21	Reticulocytopenia (HP:0001896)	3.06942224
22	Down-sloping shoulders (HP:0200021)	3.00666910
23	Exercise-induced muscle cramps (HP:0003710)	2.97141998
24	Stenosis of the external auditory canal (HP:0000402)	2.97010962
25	Nonprogressive disorder (HP:0003680)	2.94826519
26	Myotonia (HP:0002486)	2.93636391
27	Microglossia (HP:0000171)	2.93447487
28	Abnormality of the calcaneus (HP:0008364)	2.92180688
29	3-Methylglutaconic aciduria (HP:0003535)	2.89608424
30	Decreased circulating renin level (HP:0003351)	2.82611872
31	Abnormality of potassium homeostasis (HP:0011042)	2.61841007
32	Oligomenorrhea (HP:0000876)	2.56359197
33	Abnormality of the parietal bone (HP:0002696)	2.50027067
34	Difficulty running (HP:0009046)	2.47653258
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.42137699
36	Bell-shaped thorax (HP:0001591)	2.34281465
37	Increased connective tissue (HP:0009025)	2.33692253
38	Short 4th metacarpal (HP:0010044)	2.30656169
39	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.30656169
40	Maternal diabetes (HP:0009800)	2.29815945
41	Supernumerary ribs (HP:0005815)	2.27826126
42	Rhabdomyolysis (HP:0003201)	2.25303530
43	Neoplasm of the heart (HP:0100544)	2.21387403
44	Supernumerary bones of the axial skeleton (HP:0009144)	2.20888554
45	Abnormality of the 4th metacarpal (HP:0010012)	2.16905242
46	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.15222397
47	Hypoplastic iliac wings (HP:0002866)	2.12899783
48	Septo-optic dysplasia (HP:0100842)	2.12258407
49	Metatarsus adductus (HP:0001840)	2.11822414
50	Muscle stiffness (HP:0003552)	2.09676023
51	Mesomelia (HP:0003027)	2.08754031
52	Hyperphosphatemia (HP:0002905)	2.04095298
53	Hypoplastic ischia (HP:0003175)	2.03341443
54	Asplenia (HP:0001746)	2.01173283
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98666613
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94518008
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92493943
58	2-3 toe syndactyly (HP:0004691)	1.89890041
59	Abnormal rod and cone electroretinograms (HP:0008323)	1.89178847
60	Absent thumb (HP:0009777)	1.87132546
61	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.86131452
62	Rectal prolapse (HP:0002035)	1.84724336
63	Macroorchidism (HP:0000053)	1.81589662
64	Malignant hyperthermia (HP:0002047)	1.79372761
65	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.77722191
66	Muscle hypertrophy of the lower extremities (HP:0008968)	1.76752315
67	Conjunctival hamartoma (HP:0100780)	1.76484474
68	Tarsal synostosis (HP:0008368)	1.74099232
69	Molar tooth sign on MRI (HP:0002419)	1.73696425
70	Abnormality of midbrain morphology (HP:0002418)	1.73696425
71	Type II lissencephaly (HP:0007260)	1.73085714
72	Hypoplasia of the ulna (HP:0003022)	1.70964868
73	Generalized muscle weakness (HP:0003324)	1.70488171
74	Paralysis (HP:0003470)	1.70230005
75	Acute necrotizing encephalopathy (HP:0006965)	1.69792273
76	Abnormality of the ischium (HP:0003174)	1.69203095
77	Colon cancer (HP:0003003)	1.68895745
78	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.68085336
79	Hypoplasia of the radius (HP:0002984)	1.67141032
80	Ectopic kidney (HP:0000086)	1.64392151
81	Hypokalemia (HP:0002900)	1.63958305
82	Forearm undergrowth (HP:0009821)	1.63954646
83	Abnormality of the peritoneum (HP:0002585)	1.63695558
84	Intellectual disability, moderate (HP:0002342)	1.63657183
85	Adrenal hypoplasia (HP:0000835)	1.63458939
86	Congenital stationary night blindness (HP:0007642)	1.62076217
87	Oligodactyly (hands) (HP:0001180)	1.61898269
88	Abnormality of the columella (HP:0009929)	1.56819307
89	Abnormal number of erythroid precursors (HP:0012131)	1.56195168
90	Synostosis involving bones of the feet (HP:0009140)	1.55712371
91	Synostosis involving bones of the lower limbs (HP:0009138)	1.55712371
92	Poor eye contact (HP:0000817)	1.52566169
93	Abnormality of the renal collecting system (HP:0004742)	1.52224529
94	Delayed CNS myelination (HP:0002188)	1.52223469
95	Reduced subcutaneous adipose tissue (HP:0003758)	1.50551222
96	Pendular nystagmus (HP:0012043)	1.49916785
97	Progressive macrocephaly (HP:0004481)	1.48014180
98	Oligodactyly (HP:0012165)	1.46217235
99	Abolished electroretinogram (ERG) (HP:0000550)	1.45018272
100	Metabolic acidosis (HP:0001942)	1.42348653

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PHKG2	4.63035180
2	PHKG1	4.63035180
3	TIE1	4.19785188
4	OBSCN	3.83628335
5	WNK4	3.79055692
6	NME2	3.73637215
7	MUSK	2.90672103
8	TYRO3	2.80882503
9	STK16	2.63610685
10	WNK1	2.62149801
11	CAMKK2	2.48538448
12	PIK3CA	2.38168928
13	LIMK1	2.13403037
14	VRK2	1.91215628
15	CAMK1D	1.86370973
16	STK39	1.82340040
17	EPHB2	1.68401585
18	TNIK	1.59141497
19	MAP3K12	1.58318332
20	BCKDK	1.54773917
21	IRAK1	1.49487966
22	MAPK13	1.48007872
23	NUAK1	1.40807956
24	CCNB1	1.36292484
25	CASK	1.35687317
26	JAK3	1.30875317
27	CHEK2	1.30472145
28	MAP2K2	1.15587231
29	CAMK1G	1.14357984
30	DYRK1B	1.06296018
31	AURKA	1.04233907
32	DYRK2	1.04041016
33	ADRBK2	1.01023431
34	PIK3CG	0.97547922
35	CAMK2G	0.96724001
36	PINK1	0.95402041
37	MAPK7	0.95068510
38	TXK	0.91860840
39	TEC	0.90964236
40	CAMK1	0.89351232
41	LRRK2	0.85922299
42	CAMKK1	0.84066422
43	TAF1	0.78253907
44	DYRK3	0.72857143
45	CAMK4	0.72458473
46	TESK1	0.71486582
47	SGK494	0.70452504
48	SGK223	0.70452504
49	CDK4	0.67154384
50	MST4	0.67111002
51	BRAF	0.62839932
52	GRK1	0.61877123
53	ARAF	0.61453625
54	MAP2K7	0.60239697
55	MARK3	0.59240655
56	CSNK1G1	0.58219592
57	EPHA4	0.56604014
58	TAOK3	0.54920854
59	TESK2	0.53481497
60	FRK	0.52783627
61	DDR2	0.51788073
62	MAP3K11	0.51777677
63	SGK2	0.50882588
64	MAPK12	0.50379007
65	ILK	0.49713634
66	EIF2AK2	0.48666427
67	SGK1	0.45879559
68	PRKG1	0.45655079
69	MYLK	0.44830406
70	CSNK1G2	0.43791970
71	PIM1	0.41076506
72	PRKACA	0.39501366
73	OXSR1	0.39406561
74	GRK6	0.39267048
75	RPS6KA5	0.39086614
76	NLK	0.38713817
77	CSNK1A1L	0.38697439
78	ATR	0.38539603
79	PDK2	0.37962343
80	SGK3	0.37874623
81	DAPK3	0.37327185
82	DMPK	0.37071326
83	FGFR2	0.36981614
84	ABL2	0.36916438
85	RPS6KA6	0.36191293
86	VRK1	0.33233463
87	HIPK2	0.33160081
88	CSNK1G3	0.32226450
89	TLK1	0.30862659
90	DAPK2	0.30321484
91	PRKCE	0.29364272
92	AKT3	0.27494705
93	PRKCG	0.26866587
94	RPS6KL1	0.26599227
95	RPS6KC1	0.26599227
96	ITK	0.26224036
97	IKBKE	0.25733053
98	PRKCQ	0.25673358
99	STK11	0.24216599
100	RPS6KA3	0.21725641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.92077429
2	Tight junction_Homo sapiens_hsa04530	3.89896937
3	Regulation of autophagy_Homo sapiens_hsa04140	2.81711048
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.67224139
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.52148341
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.37162730
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09573586
8	Oxytocin signaling pathway_Homo sapiens_hsa04921	2.05900005
9	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79628205
10	Alzheimers disease_Homo sapiens_hsa05010	1.67363870
11	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.66857527
12	Parkinsons disease_Homo sapiens_hsa05012	1.65616415
13	Calcium signaling pathway_Homo sapiens_hsa04020	1.63569837
14	Insulin secretion_Homo sapiens_hsa04911	1.61766282
15	Gastric acid secretion_Homo sapiens_hsa04971	1.61566746
16	Basal cell carcinoma_Homo sapiens_hsa05217	1.59332889
17	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.57133722
18	Wnt signaling pathway_Homo sapiens_hsa04310	1.52362400
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49212546
20	Circadian entrainment_Homo sapiens_hsa04713	1.47636697
21	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.46511955
22	RNA degradation_Homo sapiens_hsa03018	1.44909641
23	Huntingtons disease_Homo sapiens_hsa05016	1.41454493
24	Olfactory transduction_Homo sapiens_hsa04740	1.39735060
25	Circadian rhythm_Homo sapiens_hsa04710	1.38140145
26	Morphine addiction_Homo sapiens_hsa05032	1.37524359
27	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.35167635
28	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.33680450
29	Proteasome_Homo sapiens_hsa03050	1.30119547
30	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.28711190
31	Phototransduction_Homo sapiens_hsa04744	1.21824928
32	Renin secretion_Homo sapiens_hsa04924	1.21453067
33	Salivary secretion_Homo sapiens_hsa04970	1.19673733
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17879167
35	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.16496114
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11490825
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10462284
38	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.07327857
39	RNA polymerase_Homo sapiens_hsa03020	1.04922673
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02233160
41	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.01273533
42	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.00629596
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.00011840
44	Dopaminergic synapse_Homo sapiens_hsa04728	0.98420802
45	Glucagon signaling pathway_Homo sapiens_hsa04922	0.96478417
46	Spliceosome_Homo sapiens_hsa03040	0.95730858
47	Cholinergic synapse_Homo sapiens_hsa04725	0.89916589
48	Axon guidance_Homo sapiens_hsa04360	0.83627936
49	Amphetamine addiction_Homo sapiens_hsa05031	0.78622510
50	Pancreatic secretion_Homo sapiens_hsa04972	0.77942780
51	GABAergic synapse_Homo sapiens_hsa04727	0.77112050
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76573780
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.76409559
54	Protein export_Homo sapiens_hsa03060	0.76010144
55	Long-term potentiation_Homo sapiens_hsa04720	0.75783439
56	Basal transcription factors_Homo sapiens_hsa03022	0.73313312
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.72570642
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.71783664
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70268279
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69692665
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69400012
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67480254
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66357857
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.65614866
65	Oocyte meiosis_Homo sapiens_hsa04114	0.64355590
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63939434
67	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.61225767
68	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.60185857
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58582662
70	Purine metabolism_Homo sapiens_hsa00230	0.58317422
71	Long-term depression_Homo sapiens_hsa04730	0.55163865
72	Melanogenesis_Homo sapiens_hsa04916	0.55131626
73	MAPK signaling pathway_Homo sapiens_hsa04010	0.54223055
74	Nicotine addiction_Homo sapiens_hsa05033	0.53617442
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.53012820
76	Caffeine metabolism_Homo sapiens_hsa00232	0.50211600
77	Serotonergic synapse_Homo sapiens_hsa04726	0.48577537
78	Glutathione metabolism_Homo sapiens_hsa00480	0.45932442
79	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.45660205
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44002257
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41771417
82	Melanoma_Homo sapiens_hsa05218	0.39897209
83	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37457060
84	Ras signaling pathway_Homo sapiens_hsa04014	0.37427973
85	Asthma_Homo sapiens_hsa05310	0.36892032
86	Adherens junction_Homo sapiens_hsa04520	0.36668502
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35455589
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.35058479
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33618805
90	Platelet activation_Homo sapiens_hsa04611	0.32929737
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32242118
92	Notch signaling pathway_Homo sapiens_hsa04330	0.30815626
93	Retinol metabolism_Homo sapiens_hsa00830	0.30457132
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30303777
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.29551122
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.29277443
97	Sulfur relay system_Homo sapiens_hsa04122	0.29106128
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.28256818
99	ErbB signaling pathway_Homo sapiens_hsa04012	0.27637037
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.27153532

RPL7P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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