ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.45234362
2	ribosomal small subunit assembly (GO:0000028)	5.78455610
3	ATP synthesis coupled proton transport (GO:0015986)	5.03791675
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.03791675
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.95259521
6	maturation of SSU-rRNA (GO:0030490)	4.81965384
7	protein neddylation (GO:0045116)	4.69290879
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51886545
9	viral transcription (GO:0019083)	4.39183265
10	translational termination (GO:0006415)	4.20839689
11	cytidine deamination (GO:0009972)	4.19113458
12	cytidine metabolic process (GO:0046087)	4.19113458
13	cytidine catabolic process (GO:0006216)	4.19113458
14	ribosomal large subunit biogenesis (GO:0042273)	3.96780096
15	behavioral response to nicotine (GO:0035095)	3.91222082
16	translational elongation (GO:0006414)	3.85507237
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.79203335
18	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.76777312
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.76619949
20	ribosomal small subunit biogenesis (GO:0042274)	3.75823079
21	cotranslational protein targeting to membrane (GO:0006613)	3.69768365
22	protein targeting to ER (GO:0045047)	3.69374332
23	piRNA metabolic process (GO:0034587)	3.55212734
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.52985647
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.52242466
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.52093503
27	protein localization to endoplasmic reticulum (GO:0070972)	3.49243646
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31712589
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31712589
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27288367
31	rRNA catabolic process (GO:0016075)	3.23626905
32	translational initiation (GO:0006413)	3.23086788
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.22418656
34	translation (GO:0006412)	3.22102159
35	viral life cycle (GO:0019058)	3.18869481
36	pseudouridine synthesis (GO:0001522)	3.17324240
37	positive regulation of defense response to virus by host (GO:0002230)	3.15059583
38	electron transport chain (GO:0022900)	3.12007293
39	respiratory electron transport chain (GO:0022904)	3.11459349
40	chaperone-mediated protein transport (GO:0072321)	3.09585818
41	rRNA modification (GO:0000154)	3.09297987
42	kynurenine metabolic process (GO:0070189)	3.08726050
43	cellular protein complex disassembly (GO:0043624)	3.06077661
44	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.05436499
45	rRNA metabolic process (GO:0016072)	3.04706315
46	rRNA processing (GO:0006364)	3.04691129
47	GTP biosynthetic process (GO:0006183)	2.99423849
48	ribonucleoprotein complex biogenesis (GO:0022613)	2.94672165
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90953675
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90953675
51	NADH dehydrogenase complex assembly (GO:0010257)	2.90953675
52	positive regulation of protein homodimerization activity (GO:0090073)	2.86870539
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86634852
54	termination of RNA polymerase III transcription (GO:0006386)	2.86634852
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.86261530
56	tRNA processing (GO:0008033)	2.85400233
57	protein complex biogenesis (GO:0070271)	2.83784129
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.83195880
59	indole-containing compound catabolic process (GO:0042436)	2.81019626
60	indolalkylamine catabolic process (GO:0046218)	2.81019626
61	tryptophan catabolic process (GO:0006569)	2.81019626
62	cellular component biogenesis (GO:0044085)	2.80735937
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.79357995
64	regulation of isotype switching to IgG isotypes (GO:0048302)	2.78906113
65	ATP biosynthetic process (GO:0006754)	2.78071258
66	negative regulation of telomere maintenance (GO:0032205)	2.76867349
67	hydrogen ion transmembrane transport (GO:1902600)	2.75171635
68	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.73122597
69	indolalkylamine metabolic process (GO:0006586)	2.72786695
70	maturation of 5.8S rRNA (GO:0000460)	2.72152539
71	regulation of chronic inflammatory response (GO:0002676)	2.70102985
72	protein-cofactor linkage (GO:0018065)	2.70033039
73	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69019457
74	positive regulation of T-helper 1 type immune response (GO:0002827)	2.65958682
75	interferon-gamma production (GO:0032609)	2.65073774
76	proteasome assembly (GO:0043248)	2.64849602
77	proton transport (GO:0015992)	2.63902472
78	DNA methylation involved in gamete generation (GO:0043046)	2.63092154
79	regulation of cellular amino acid metabolic process (GO:0006521)	2.61967795
80	positive regulation of prostaglandin secretion (GO:0032308)	2.61047482
81	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.59684510
82	hydrogen transport (GO:0006818)	2.58077758
83	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.57906743
84	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.57552054
85	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.57171733
86	respiratory chain complex IV assembly (GO:0008535)	2.56948125
87	ubiquinone biosynthetic process (GO:0006744)	2.56844142
88	aldehyde catabolic process (GO:0046185)	2.56240509
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.53360375
90	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52752934
91	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.52208881
92	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.52208881
93	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.52208881
94	protein complex disassembly (GO:0043241)	2.50890864
95	ncRNA processing (GO:0034470)	2.49044441
96	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.49041262
97	pyrimidine nucleotide catabolic process (GO:0006244)	2.47846218
98	mRNA catabolic process (GO:0006402)	2.47009497
99	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.46610960
100	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.46610960

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.29838739
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.15591853
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.97750009
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43505827
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.37607301
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.04006826
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00891056
8	VDR_22108803_ChIP-Seq_LS180_Human	3.00182880
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92206294
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.69217336
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.67484136
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.48548778
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35645530
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31931001
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26587980
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.26401348
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.20035639
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18690505
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.16227910
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12887354
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89441021
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.86172934
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83525583
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.79108003
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75785865
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.75021205
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74984162
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70532300
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66537910
30	EWS_26573619_Chip-Seq_HEK293_Human	1.62575566
31	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.60940567
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.60822956
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59363334
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55394154
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52760204
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.51471207
37	FUS_26573619_Chip-Seq_HEK293_Human	1.44356579
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42301849
39	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.40926190
40	GATA3_26560356_Chip-Seq_TH2_Human	1.37877606
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36281103
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.35610926
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35269992
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.34009566
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32498813
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29954588
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.28929136
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26714927
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.26204652
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25863008
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25863008
52	AR_20517297_ChIP-Seq_VCAP_Human	1.22516453
53	NCOR_22424771_ChIP-Seq_293T_Human	1.20947632
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20849211
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20170084
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20032319
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19841308
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19631594
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19431287
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16392306
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14986666
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14495174
63	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14089974
64	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14006022
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13981444
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.13895573
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12579185
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10731864
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10658312
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10343523
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.10225600
72	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07684114
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06842495
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06733987
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06733987
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04336005
77	XRN2_22483619_ChIP-Seq_HELA_Human	1.04171188
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.03623849
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03623849
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03590668
81	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02952685
82	DCP1A_22483619_ChIP-Seq_HELA_Human	1.01702535
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01219454
84	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01064038
85	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00562180
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00254943
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99837961
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99393388
89	MYB_26560356_Chip-Seq_TH2_Human	0.99148616
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98942764
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98899479
92	ERA_21632823_ChIP-Seq_H3396_Human	0.97781944
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94422729
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94116638
95	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92893067
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.91000594
97	GATA3_26560356_Chip-Seq_TH1_Human	0.90834377
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90337353
99	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.89668994
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89644105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.59815224
2	MP0009379_abnormal_foot_pigmentation	3.02201537
3	MP0008877_abnormal_DNA_methylation	3.01934635
4	MP0001835_abnormal_antigen_presentation	2.81354057
5	MP0002102_abnormal_ear_morphology	2.52479647
6	MP0006292_abnormal_olfactory_placode	2.48475300
7	MP0002138_abnormal_hepatobiliary_system	2.29570594
8	MP0008875_abnormal_xenobiotic_pharmacok	2.18172548
9	MP0000685_abnormal_immune_system	2.16238939
10	MP0006072_abnormal_retinal_apoptosis	2.05831490
11	MP0008872_abnormal_physiological_respon	2.05178752
12	MP0004145_abnormal_muscle_electrophysio	2.01198113
13	MP0004147_increased_porphyrin_level	1.97460205
14	MP0002006_tumorigenesis	1.95825813
15	MP0001986_abnormal_taste_sensitivity	1.91287626
16	MP0001800_abnormal_humoral_immune	1.87848839
17	MP0005646_abnormal_pituitary_gland	1.84129264
18	MP0008058_abnormal_DNA_repair	1.83768033
19	MP0002166_altered_tumor_susceptibility	1.78638794
20	MP0003646_muscle_fatigue	1.77324798
21	MP0001968_abnormal_touch/_nociception	1.76634455
22	MP0003786_premature_aging	1.75551525
23	MP0002148_abnormal_hypersensitivity_rea	1.66673660
24	MP0003787_abnormal_imprinting	1.64810254
25	MP0005551_abnormal_eye_electrophysiolog	1.63446632
26	MP0005000_abnormal_immune_tolerance	1.60784179
27	MP0005645_abnormal_hypothalamus_physiol	1.59200306
28	MP0001790_abnormal_immune_system	1.59179221
29	MP0005387_immune_system_phenotype	1.59179221
30	MP0009785_altered_susceptibility_to	1.57146473
31	MP0005084_abnormal_gallbladder_morpholo	1.52261004
32	MP0004142_abnormal_muscle_tone	1.50573113
33	MP0002876_abnormal_thyroid_physiology	1.49069772
34	MP0002723_abnormal_immune_serum	1.48459866
35	MP0002736_abnormal_nociception_after	1.46441341
36	MP0001873_stomach_inflammation	1.44762966
37	MP0004885_abnormal_endolymph	1.43994849
38	MP0002163_abnormal_gland_morphology	1.37990337
39	MP0009764_decreased_sensitivity_to	1.37387569
40	MP0002420_abnormal_adaptive_immunity	1.32582459
41	MP0001819_abnormal_immune_cell	1.30393585
42	MP0000372_irregular_coat_pigmentation	1.30073674
43	MP0002234_abnormal_pharynx_morphology	1.29575999
44	MP0002452_abnormal_antigen_presenting	1.27260932
45	MP0003806_abnormal_nucleotide_metabolis	1.24357238
46	MP0002272_abnormal_nervous_system	1.22113273
47	MP0002160_abnormal_reproductive_system	1.21247300
48	MP0002653_abnormal_ependyma_morphology	1.20891365
49	MP0006276_abnormal_autonomic_nervous	1.19929547
50	MP0001905_abnormal_dopamine_level	1.19020136
51	MP0005389_reproductive_system_phenotype	1.15291514
52	MP0003866_abnormal_defecation	1.14252075
53	MP0001293_anophthalmia	1.14231920
54	MP0008775_abnormal_heart_ventricle	1.13716727
55	MP0001984_abnormal_olfaction	1.12972677
56	MP0002837_dystrophic_cardiac_calcinosis	1.11395361
57	MP0006036_abnormal_mitochondrial_physio	1.08583212
58	MP0003763_abnormal_thymus_physiology	1.06940234
59	MP0009333_abnormal_splenocyte_physiolog	1.06510933
60	MP0001501_abnormal_sleep_pattern	1.06449532
61	MP0006035_abnormal_mitochondrial_morpho	1.03965593
62	MP0003252_abnormal_bile_duct	1.03191614
63	MP0003693_abnormal_embryo_hatching	1.03154740
64	MP0008995_early_reproductive_senescence	1.02633716
65	MP0002733_abnormal_thermal_nociception	1.02336691
66	MP0002398_abnormal_bone_marrow	1.00546918
67	MP0005253_abnormal_eye_physiology	1.00367015
68	MP0003880_abnormal_central_pattern	0.99710694
69	MP0008789_abnormal_olfactory_epithelium	0.99131440
70	MP0003718_maternal_effect	0.98464982
71	MP0000689_abnormal_spleen_morphology	0.97412694
72	MP0005075_abnormal_melanosome_morpholog	0.96152097
73	MP0005025_abnormal_response_to	0.92915131
74	MP0000716_abnormal_immune_system	0.92713883
75	MP0001970_abnormal_pain_threshold	0.92596162
76	MP0009745_abnormal_behavioral_response	0.91228228
77	MP0002095_abnormal_skin_pigmentation	0.90131371
78	MP0003011_delayed_dark_adaptation	0.88211430
79	MP0002210_abnormal_sex_determination	0.87669308
80	MP0003186_abnormal_redox_activity	0.86481208
81	MP0001845_abnormal_inflammatory_respons	0.84943052
82	MP0005423_abnormal_somatic_nervous	0.84721635
83	MP0005085_abnormal_gallbladder_physiolo	0.84498236
84	MP0000631_abnormal_neuroendocrine_gland	0.84331557
85	MP0003195_calcinosis	0.83939949
86	MP0001919_abnormal_reproductive_system	0.83554773
87	MP0010094_abnormal_chromosome_stability	0.83267419
88	MP0001119_abnormal_female_reproductive	0.83111179
89	MP0001502_abnormal_circadian_rhythm	0.83088377
90	MP0009046_muscle_twitch	0.82770380
91	MP0005410_abnormal_fertilization	0.78664286
92	MP0002429_abnormal_blood_cell	0.78517642
93	MP0005636_abnormal_mineral_homeostasis	0.77890564
94	MP0001929_abnormal_gametogenesis	0.75941271
95	MP0005195_abnormal_posterior_eye	0.75825653
96	MP0001440_abnormal_grooming_behavior	0.75600548
97	MP0010155_abnormal_intestine_physiology	0.74995421
98	MP0002693_abnormal_pancreas_physiology	0.74828465
99	MP0001485_abnormal_pinna_reflex	0.71290316
100	MP0000703_abnormal_thymus_morphology	0.70238948

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	3.99721318
2	Acute necrotizing encephalopathy (HP:0006965)	3.88845754
3	Reticulocytopenia (HP:0001896)	3.62492271
4	Acute encephalopathy (HP:0006846)	3.57265297
5	IgG deficiency (HP:0004315)	3.54664795
6	Pancreatic cysts (HP:0001737)	3.46144112
7	Mitochondrial inheritance (HP:0001427)	3.42551917
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38634550
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.27490490
10	Increased CSF lactate (HP:0002490)	3.26288718
11	Progressive macrocephaly (HP:0004481)	3.25830833
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15290829
13	Increased hepatocellular lipid droplets (HP:0006565)	3.07715838
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07546834
15	Lipid accumulation in hepatocytes (HP:0006561)	3.04189892
16	Congenital stationary night blindness (HP:0007642)	2.96762247
17	Pancreatic fibrosis (HP:0100732)	2.92533852
18	Hepatocellular necrosis (HP:0001404)	2.89312723
19	Abnormality of midbrain morphology (HP:0002418)	2.88868596
20	Molar tooth sign on MRI (HP:0002419)	2.88868596
21	Abolished electroretinogram (ERG) (HP:0000550)	2.82836688
22	Increased serum lactate (HP:0002151)	2.79057582
23	Optic disc pallor (HP:0000543)	2.78939332
24	Type II lissencephaly (HP:0007260)	2.78612663
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.72318755
26	True hermaphroditism (HP:0010459)	2.72042874
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70142974
28	Nephronophthisis (HP:0000090)	2.67114610
29	Hepatic necrosis (HP:0002605)	2.66411497
30	Congenital, generalized hypertrichosis (HP:0004540)	2.66119270
31	Abnormal number of erythroid precursors (HP:0012131)	2.66096453
32	Stenosis of the external auditory canal (HP:0000402)	2.59096510
33	Attenuation of retinal blood vessels (HP:0007843)	2.52580540
34	Cerebral edema (HP:0002181)	2.50312562
35	Increased IgM level (HP:0003496)	2.49296323
36	Macrocytic anemia (HP:0001972)	2.47020242
37	Decreased central vision (HP:0007663)	2.44047512
38	Stomatitis (HP:0010280)	2.43558715
39	Pendular nystagmus (HP:0012043)	2.41726841
40	Abnormality of the renal cortex (HP:0011035)	2.40919744
41	Absent thumb (HP:0009777)	2.36813464
42	Abnormality of the prostate (HP:0008775)	2.36807331
43	Abnormality of the renal medulla (HP:0100957)	2.36585938
44	Hypoproteinemia (HP:0003075)	2.34301631
45	Type 2 muscle fiber atrophy (HP:0003554)	2.33208927
46	Aplastic anemia (HP:0001915)	2.32980260
47	Lactic acidosis (HP:0003128)	2.32697040
48	Keratoconus (HP:0000563)	2.30613634
49	Increased corneal curvature (HP:0100692)	2.30613634
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.27004321
51	Abnormality of alanine metabolism (HP:0010916)	2.25253729
52	Hyperalaninemia (HP:0003348)	2.25253729
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.25253729
54	Abnormality of the labia minora (HP:0012880)	2.23852801
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21704160
56	Renal Fanconi syndrome (HP:0001994)	2.21530098
57	Increased intramyocellular lipid droplets (HP:0012240)	2.21031700
58	Asplenia (HP:0001746)	2.20823867
59	Dyschromatopsia (HP:0007641)	2.19394338
60	Abnormality of the renal collecting system (HP:0004742)	2.10530278
61	Methylmalonic acidemia (HP:0002912)	2.10155045
62	Severe combined immunodeficiency (HP:0004430)	2.10029069
63	Medial flaring of the eyebrow (HP:0010747)	2.09818520
64	Colon cancer (HP:0003003)	2.04367905
65	Autoimmune hemolytic anemia (HP:0001890)	2.00872443
66	Cerebellar dysplasia (HP:0007033)	2.00762027
67	Constricted visual fields (HP:0001133)	2.00742349
68	Panhypogammaglobulinemia (HP:0003139)	1.99512398
69	Pancytopenia (HP:0001876)	1.99290610
70	Lethargy (HP:0001254)	1.98988513
71	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98767175
72	Muscle fiber atrophy (HP:0100295)	1.94259089
73	Cystic liver disease (HP:0006706)	1.91568496
74	Pallor (HP:0000980)	1.89263670
75	Sclerocornea (HP:0000647)	1.88779459
76	Abnormality of T cells (HP:0002843)	1.88208991
77	Increased muscle lipid content (HP:0009058)	1.87409048
78	Leukodystrophy (HP:0002415)	1.86065813
79	Polyuria (HP:0000103)	1.85903011
80	Duplicated collecting system (HP:0000081)	1.85834168
81	Exertional dyspnea (HP:0002875)	1.82803491
82	Polydipsia (HP:0001959)	1.82698195
83	Abnormal drinking behavior (HP:0030082)	1.82698195
84	Abnormality of T cell physiology (HP:0011840)	1.80686688
85	Agammaglobulinemia (HP:0004432)	1.79983561
86	Renal cortical cysts (HP:0000803)	1.77440792
87	Abnormality of B cell number (HP:0010975)	1.73108062
88	Methylmalonic aciduria (HP:0012120)	1.72494215
89	Tubular atrophy (HP:0000092)	1.72203678
90	Abnormality of DNA repair (HP:0003254)	1.71411373
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.70404351
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.70404351
93	Respiratory failure (HP:0002878)	1.68104648
94	Prostate neoplasm (HP:0100787)	1.67100024
95	Absent/shortened dynein arms (HP:0200106)	1.66850813
96	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.66850813
97	Abnormality of the pons (HP:0007361)	1.66701346
98	Thyroiditis (HP:0100646)	1.65810065
99	Aplasia/hypoplasia of the uterus (HP:0008684)	1.65369388
100	Abnormality of T cell number (HP:0011839)	1.64585566

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.26911816
2	NUAK1	3.20111127
3	ZAK	3.18749616
4	TAOK3	2.99128072
5	TLK1	2.94015143
6	ADRBK2	2.79627709
7	WNK4	2.42164880
8	VRK2	2.35856632
9	GRK1	2.12331853
10	MAP4K2	2.04259081
11	CDK19	2.03935720
12	BMPR1B	2.03490181
13	FRK	1.94781341
14	MAP4K1	1.90263337
15	PINK1	1.90176863
16	MST4	1.88392613
17	STK16	1.82955778
18	BCKDK	1.69800628
19	OXSR1	1.57776624
20	FES	1.56729631
21	EIF2AK3	1.56452724
22	EIF2AK1	1.52828518
23	VRK1	1.48353081
24	KIT	1.48319654
25	ITK	1.47130043
26	MAPKAPK3	1.40044738
27	TEC	1.35554316
28	STK39	1.34176645
29	KDR	1.29177030
30	DYRK2	1.28552381
31	IKBKB	1.23415819
32	PIK3CA	1.12614257
33	DAPK1	1.12185304
34	SYK	1.11349130
35	BUB1	1.08596019
36	PRKCQ	1.08496135
37	WNK3	1.08271291
38	MAP3K4	1.05976810
39	BTK	0.97845597
40	PHKG1	0.95762897
41	PHKG2	0.95762897
42	TIE1	0.94447528
43	EIF2AK2	0.91382896
44	NEK1	0.88300113
45	TSSK6	0.88051920
46	MAP3K12	0.87641989
47	MAP3K14	0.85649209
48	SRPK1	0.85181342
49	PLK3	0.85164469
50	RPS6KA5	0.84645599
51	NME1	0.83483831
52	MKNK1	0.83281735
53	MAPKAPK5	0.80395735
54	ADRBK1	0.78026235
55	MUSK	0.75238912
56	LYN	0.69898287
57	GRK7	0.69332888
58	PLK2	0.68811671
59	MAPK13	0.66232298
60	PASK	0.66069672
61	CSF1R	0.65459129
62	LCK	0.65384547
63	IKBKE	0.61478386
64	GRK5	0.59737739
65	CDC7	0.59432910
66	PLK4	0.58535754
67	CAMKK2	0.56956341
68	ATR	0.56176434
69	CDK8	0.56011240
70	INSRR	0.55944140
71	TRIM28	0.54292131
72	PDK2	0.53749640
73	FLT3	0.51577726
74	BMPR2	0.50708854
75	NME2	0.49368832
76	CSNK2A2	0.49106372
77	PLK1	0.48251881
78	PRKCG	0.48173357
79	IGF1R	0.47956860
80	CSNK1G3	0.47090840
81	AURKB	0.46521603
82	TAF1	0.45425223
83	CSNK1G2	0.45056444
84	GRK6	0.44833555
85	CSNK2A1	0.44356795
86	DAPK3	0.43907071
87	LRRK2	0.43576637
88	MAP2K2	0.42505815
89	MAP2K6	0.42275643
90	PRKACA	0.40611041
91	AKT3	0.40485144
92	TGFBR1	0.38148978
93	PRKCI	0.35047792
94	JAK3	0.35036790
95	PRKCD	0.34942517
96	PIK3CG	0.34400473
97	RPS6KB2	0.34270646
98	PRKCA	0.33247709
99	CSNK1G1	0.32895585
100	ALK	0.32305967

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.01541370
2	Asthma_Homo sapiens_hsa05310	3.61249350
3	Proteasome_Homo sapiens_hsa03050	3.24593965
4	Allograft rejection_Homo sapiens_hsa05330	3.02843691
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.02760047
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.00504162
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.94085505
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.62866110
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.52316596
10	Parkinsons disease_Homo sapiens_hsa05012	2.44584884
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.38107412
12	RNA polymerase_Homo sapiens_hsa03020	2.33371626
13	One carbon pool by folate_Homo sapiens_hsa00670	2.20300088
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.11387894
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.84234308
16	Protein export_Homo sapiens_hsa03060	1.80895876
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.79210665
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74440853
19	RNA degradation_Homo sapiens_hsa03018	1.70239891
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67006916
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63865409
22	Homologous recombination_Homo sapiens_hsa03440	1.57718975
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54380001
24	Mismatch repair_Homo sapiens_hsa03430	1.52939077
25	Huntingtons disease_Homo sapiens_hsa05016	1.50396055
26	Basal transcription factors_Homo sapiens_hsa03022	1.50094587
27	Alzheimers disease_Homo sapiens_hsa05010	1.48162462
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44257817
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41695737
30	Phototransduction_Homo sapiens_hsa04744	1.40464524
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34719152
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25207434
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24858535
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23337556
35	Propanoate metabolism_Homo sapiens_hsa00640	1.20433357
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.15554230
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.14831829
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12261503
39	RNA transport_Homo sapiens_hsa03013	1.06838212
40	DNA replication_Homo sapiens_hsa03030	1.06783631
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04965822
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04129056
43	Spliceosome_Homo sapiens_hsa03040	0.99309843
44	Purine metabolism_Homo sapiens_hsa00230	0.93952135
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.92897232
46	Viral myocarditis_Homo sapiens_hsa05416	0.89067332
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88237600
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87584746
49	Caffeine metabolism_Homo sapiens_hsa00232	0.87091574
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86066970
51	Peroxisome_Homo sapiens_hsa04146	0.84802047
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83816717
53	Butanoate metabolism_Homo sapiens_hsa00650	0.80583423
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.76118161
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75767337
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74622530
57	Base excision repair_Homo sapiens_hsa03410	0.74440392
58	Olfactory transduction_Homo sapiens_hsa04740	0.72957490
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69413878
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68920580
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65499196
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65391063
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65226672
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64551859
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63403932
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.62775923
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.62548990
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59976997
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58547073
70	Regulation of autophagy_Homo sapiens_hsa04140	0.55773952
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.55321793
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53537089
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51753032
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48713166
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47687061
76	Metabolic pathways_Homo sapiens_hsa01100	0.45753444
77	Leishmaniasis_Homo sapiens_hsa05140	0.45616662
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45102253
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.44989164
80	Measles_Homo sapiens_hsa05162	0.41326813
81	Herpes simplex infection_Homo sapiens_hsa05168	0.40269606
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39173129
83	Retinol metabolism_Homo sapiens_hsa00830	0.38288972
84	Folate biosynthesis_Homo sapiens_hsa00790	0.35456924
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35382703
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35198811
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34648554
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33206649
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.32457844
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32055885
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31454654
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.29909096
93	Sulfur relay system_Homo sapiens_hsa04122	0.26126654
94	Taste transduction_Homo sapiens_hsa04742	0.24459574
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22156012
96	Nicotine addiction_Homo sapiens_hsa05033	0.19688925
97	Morphine addiction_Homo sapiens_hsa05032	0.19268320
98	Sulfur metabolism_Homo sapiens_hsa00920	0.18777070
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.16883398
100	Serotonergic synapse_Homo sapiens_hsa04726	0.13692090

RPL7P50

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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