ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.90866938
2	ATP synthesis coupled proton transport (GO:0015986)	4.90866938
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68442720
4	cell wall macromolecule catabolic process (GO:0016998)	4.19544092
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.08028865
6	ribosomal large subunit biogenesis (GO:0042273)	4.01867052
7	tryptophan metabolic process (GO:0006568)	3.91045486
8	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.84977299
9	DNA deamination (GO:0045006)	3.71189316
10	indole-containing compound catabolic process (GO:0042436)	3.70602780
11	indolalkylamine catabolic process (GO:0046218)	3.70602780
12	tryptophan catabolic process (GO:0006569)	3.70602780
13	kynurenine metabolic process (GO:0070189)	3.68255930
14	protein complex biogenesis (GO:0070271)	3.63938044
15	immunoglobulin mediated immune response (GO:0016064)	3.62476942
16	cell wall macromolecule metabolic process (GO:0044036)	3.58148669
17	respiratory electron transport chain (GO:0022904)	3.56967840
18	electron transport chain (GO:0022900)	3.55726170
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49437352
20	NADH dehydrogenase complex assembly (GO:0010257)	3.49437352
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49437352
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44601620
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44601620
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42946102
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.37290808
26	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.34684542
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33848820
28	aldehyde catabolic process (GO:0046185)	3.33721532
29	indolalkylamine metabolic process (GO:0006586)	3.33060451
30	regulation of hypersensitivity (GO:0002883)	3.32432937
31	negative regulation of heart rate (GO:0010459)	3.32106720
32	ribosomal small subunit assembly (GO:0000028)	3.31267280
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26906941
34	piRNA metabolic process (GO:0034587)	3.24128576
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.19339452
36	B cell mediated immunity (GO:0019724)	3.15683244
37	response to pheromone (GO:0019236)	3.06779255
38	rRNA catabolic process (GO:0016075)	3.06132458
39	termination of RNA polymerase III transcription (GO:0006386)	3.04895066
40	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.04895066
41	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04030475
42	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.94302978
43	viral transcription (GO:0019083)	2.87164329
44	maturation of SSU-rRNA (GO:0030490)	2.84685145
45	mast cell activation (GO:0045576)	2.82925937
46	GPI anchor biosynthetic process (GO:0006506)	2.82894102
47	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.82140249
48	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.80975151
49	GPI anchor metabolic process (GO:0006505)	2.79842762
50	behavioral response to nicotine (GO:0035095)	2.78962493
51	respiratory chain complex IV assembly (GO:0008535)	2.77916689
52	rRNA modification (GO:0000154)	2.77658433
53	translational termination (GO:0006415)	2.77111558
54	regulation of germinal center formation (GO:0002634)	2.74039403
55	cytochrome complex assembly (GO:0017004)	2.73568726
56	cotranslational protein targeting to membrane (GO:0006613)	2.72982458
57	protein targeting to ER (GO:0045047)	2.72967240
58	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.71359568
59	positive regulation of prostaglandin secretion (GO:0032308)	2.71060200
60	negative regulation of mast cell activation (GO:0033004)	2.70356745
61	interferon-gamma-mediated signaling pathway (GO:0060333)	2.70258763
62	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.68793164
63	positive regulation of mast cell degranulation (GO:0043306)	2.68793164
64	fucose catabolic process (GO:0019317)	2.66555162
65	L-fucose metabolic process (GO:0042354)	2.66555162
66	L-fucose catabolic process (GO:0042355)	2.66555162
67	protein localization to endoplasmic reticulum (GO:0070972)	2.65271864
68	hydrogen ion transmembrane transport (GO:1902600)	2.65126247
69	ATP biosynthetic process (GO:0006754)	2.63535593
70	positive regulation of protein homodimerization activity (GO:0090073)	2.61413239
71	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.61319331
72	amine catabolic process (GO:0009310)	2.60888325
73	cellular biogenic amine catabolic process (GO:0042402)	2.60888325
74	regulation of antigen processing and presentation (GO:0002577)	2.60537886
75	mannosylation (GO:0097502)	2.57982890
76	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.57913598
77	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.57595694
78	proton transport (GO:0015992)	2.57357753
79	protein-cofactor linkage (GO:0018065)	2.57188827
80	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.55377801
81	hydrogen transport (GO:0006818)	2.54799453
82	translational elongation (GO:0006414)	2.53675427
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.53482615
84	cellular response to exogenous dsRNA (GO:0071360)	2.52364637
85	spliceosomal complex assembly (GO:0000245)	2.52155652
86	response to interferon-beta (GO:0035456)	2.51985748
87	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.51409411
88	isotype switching (GO:0045190)	2.51409411
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.51409411
90	protein neddylation (GO:0045116)	2.50996737
91	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.50807621
92	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.50586816
93	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49488530
94	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.48958909
95	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.48534170
96	regulation of interleukin-8 secretion (GO:2000482)	2.46682045
97	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.45952256
98	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.45439298
99	oxidative phosphorylation (GO:0006119)	2.45042065
100	positive regulation of mast cell activation (GO:0033005)	2.44516966

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.47930800
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.60968415
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.28241898
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.17910696
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.08409625
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.80315250
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.75632302
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.74267557
9	VDR_22108803_ChIP-Seq_LS180_Human	2.61984731
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.61218484
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43912720
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.31599178
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.27699597
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26907692
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.24797522
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.19815188
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99024855
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88303272
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.77764912
20	GATA3_26560356_Chip-Seq_TH2_Human	1.76219442
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.72869363
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72539384
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70264803
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68991151
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68972913
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.67170162
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.63891883
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.63562883
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.63562883
30	EWS_26573619_Chip-Seq_HEK293_Human	1.59771774
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.58370330
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53142287
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.52387477
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.50575780
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.46532555
36	FUS_26573619_Chip-Seq_HEK293_Human	1.46222264
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.44724516
38	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.43742826
39	AR_20517297_ChIP-Seq_VCAP_Human	1.43380128
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42234278
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42102697
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39912067
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39912067
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39365205
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.39365205
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39202048
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37744274
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33318487
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32146665
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30790016
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29968547
52	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.28483460
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28133507
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27752064
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27531081
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25998684
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25188221
58	P300_19829295_ChIP-Seq_ESCs_Human	1.23838139
59	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23711645
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22719937
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21413962
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20576553
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18594287
64	MYB_26560356_Chip-Seq_TH2_Human	1.16229243
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15987283
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.15323703
67	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14597600
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14090361
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13787051
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13202135
71	NCOR_22424771_ChIP-Seq_293T_Human	1.13008270
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12802249
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10765563
74	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.08816251
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08222740
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07860662
77	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06527440
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06508972
79	STAT1_20625510_ChIP-Seq_HELA_Human	1.05262605
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.05098001
81	SPI1_23547873_ChIP-Seq_NB4_Human	1.05001221
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04801468
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04597079
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04256677
85	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04191315
86	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04106769
87	GATA3_26560356_Chip-Seq_TH1_Human	1.02715510
88	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01675826
89	GBX2_23144817_ChIP-Seq_PC3_Human	1.01297817
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.01190073
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99914636
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99322428
93	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98998605
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97018308
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97014627
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97012774
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.96596148
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96271835
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95793069
100	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94263836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.72397262
2	MP0005671_abnormal_response_to	3.55540436
3	MP0002138_abnormal_hepatobiliary_system	2.96831722
4	MP0003806_abnormal_nucleotide_metabolis	2.86539359
5	MP0008875_abnormal_xenobiotic_pharmacok	2.68715596
6	MP0004147_increased_porphyrin_level	2.60866453
7	MP0008872_abnormal_physiological_respon	2.28662878
8	MP0003724_increased_susceptibility_to	2.20594866
9	MP0002148_abnormal_hypersensitivity_rea	2.16136687
10	MP0001800_abnormal_humoral_immune	2.12038734
11	MP0000685_abnormal_immune_system	2.06067124
12	MP0006072_abnormal_retinal_apoptosis	2.06018645
13	MP0005646_abnormal_pituitary_gland	2.00767680
14	MP0002166_altered_tumor_susceptibility	1.99591423
15	MP0009785_altered_susceptibility_to	1.97877831
16	MP0005084_abnormal_gallbladder_morpholo	1.91266333
17	MP0006292_abnormal_olfactory_placode	1.89193484
18	MP0009379_abnormal_foot_pigmentation	1.85737193
19	MP0009764_decreased_sensitivity_to	1.85651350
20	MP0001968_abnormal_touch/_nociception	1.84831932
21	MP0002006_tumorigenesis	1.80217137
22	MP0005000_abnormal_immune_tolerance	1.79322803
23	MP0008877_abnormal_DNA_methylation	1.77808141
24	MP0004142_abnormal_muscle_tone	1.75745195
25	MP0001986_abnormal_taste_sensitivity	1.62808275
26	MP0002452_abnormal_antigen_presenting	1.62366219
27	MP0002723_abnormal_immune_serum	1.56770988
28	MP0000372_irregular_coat_pigmentation	1.54746526
29	MP0003011_delayed_dark_adaptation	1.52539771
30	MP0005075_abnormal_melanosome_morpholog	1.45278911
31	MP0005410_abnormal_fertilization	1.44327252
32	MP0005551_abnormal_eye_electrophysiolog	1.43508990
33	MP0005645_abnormal_hypothalamus_physiol	1.42981997
34	MP0001819_abnormal_immune_cell	1.40591854
35	MP0002876_abnormal_thyroid_physiology	1.40128748
36	MP0002837_dystrophic_cardiac_calcinosis	1.39924617
37	MP0002420_abnormal_adaptive_immunity	1.38631174
38	MP0004145_abnormal_muscle_electrophysio	1.37941234
39	MP0006036_abnormal_mitochondrial_physio	1.37895162
40	MP0003252_abnormal_bile_duct	1.37438673
41	MP0001790_abnormal_immune_system	1.36535144
42	MP0005387_immune_system_phenotype	1.36535144
43	MP0001905_abnormal_dopamine_level	1.33926439
44	MP0005377_hearing/vestibular/ear_phenot	1.30435445
45	MP0003878_abnormal_ear_physiology	1.30435445
46	MP0002736_abnormal_nociception_after	1.29683833
47	MP0005367_renal/urinary_system_phenotyp	1.26996908
48	MP0000516_abnormal_urinary_system	1.26996908
49	MP0001984_abnormal_olfaction	1.24048104
50	MP0010155_abnormal_intestine_physiology	1.23545867
51	MP0002102_abnormal_ear_morphology	1.22915584
52	MP0008058_abnormal_DNA_repair	1.21760542
53	MP0004885_abnormal_endolymph	1.20104637
54	MP0001440_abnormal_grooming_behavior	1.19388368
55	MP0003786_premature_aging	1.19357559
56	MP0003866_abnormal_defecation	1.16766913
57	MP0005253_abnormal_eye_physiology	1.16131064
58	MP0003646_muscle_fatigue	1.15931445
59	MP0005167_abnormal_blood-brain_barrier	1.15888511
60	MP0005389_reproductive_system_phenotype	1.12243257
61	MP0001919_abnormal_reproductive_system	1.11134031
62	MP0003718_maternal_effect	1.10649630
63	MP0003186_abnormal_redox_activity	1.09514338
64	MP0002272_abnormal_nervous_system	1.06456771
65	MP0003436_decreased_susceptibility_to	1.06160380
66	MP0001501_abnormal_sleep_pattern	1.05829532
67	MP0003195_calcinosis	1.04807522
68	MP0010386_abnormal_urinary_bladder	1.01944260
69	MP0002419_abnormal_innate_immunity	1.01131231
70	MP0001529_abnormal_vocalization	1.00171309
71	MP0005085_abnormal_gallbladder_physiolo	0.98834908
72	MP0001845_abnormal_inflammatory_respons	0.97359753
73	MP0000716_abnormal_immune_system	0.96721346
74	MP0003763_abnormal_thymus_physiology	0.96671438
75	MP0000013_abnormal_adipose_tissue	0.96202114
76	MP0008469_abnormal_protein_level	0.95977889
77	MP0001970_abnormal_pain_threshold	0.95176204
78	MP0005025_abnormal_response_to	0.94132546
79	MP0001486_abnormal_startle_reflex	0.93975547
80	MP0002398_abnormal_bone_marrow	0.93952599
81	MP0005332_abnormal_amino_acid	0.93629995
82	MP0009046_muscle_twitch	0.92322305
83	MP0006035_abnormal_mitochondrial_morpho	0.91433647
84	MP0002234_abnormal_pharynx_morphology	0.90507743
85	MP0009333_abnormal_splenocyte_physiolog	0.90375207
86	MP0005636_abnormal_mineral_homeostasis	0.90210221
87	MP0000230_abnormal_systemic_arterial	0.89906603
88	MP0000569_abnormal_digit_pigmentation	0.89774245
89	MP0003638_abnormal_response/metabolism_	0.88135713
90	MP0009745_abnormal_behavioral_response	0.86645303
91	MP0001853_heart_inflammation	0.85157202
92	MP0008775_abnormal_heart_ventricle	0.82915550
93	MP0001765_abnormal_ion_homeostasis	0.79868721
94	MP0000689_abnormal_spleen_morphology	0.74968046
95	MP0009643_abnormal_urine_homeostasis	0.74195057
96	MP0002429_abnormal_blood_cell	0.73983073
97	MP0002733_abnormal_thermal_nociception	0.73775134
98	MP0006276_abnormal_autonomic_nervous	0.73756956
99	MP0004043_abnormal_pH_regulation	0.72738575
100	MP0002928_abnormal_bile_duct	0.69862870

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.21351858
2	Hepatocellular necrosis (HP:0001404)	4.19558366
3	Acute necrotizing encephalopathy (HP:0006965)	4.11242569
4	Mitochondrial inheritance (HP:0001427)	3.92487011
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.73405873
6	Increased CSF lactate (HP:0002490)	3.68037645
7	Hepatic necrosis (HP:0002605)	3.67937080
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.63873329
9	Progressive macrocephaly (HP:0004481)	3.57671013
10	3-Methylglutaconic aciduria (HP:0003535)	3.52411996
11	Acute encephalopathy (HP:0006846)	3.47524557
12	Abnormality of the prostate (HP:0008775)	3.32807515
13	IgG deficiency (HP:0004315)	3.20462075
14	Type II lissencephaly (HP:0007260)	3.15930346
15	Hypoproteinemia (HP:0003075)	2.96320475
16	Congenital stationary night blindness (HP:0007642)	2.93376149
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.89571194
18	Absent/shortened dynein arms (HP:0200106)	2.89571194
19	Increased hepatocellular lipid droplets (HP:0006565)	2.88586221
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.86997373
21	Abolished electroretinogram (ERG) (HP:0000550)	2.86698079
22	Lipid accumulation in hepatocytes (HP:0006561)	2.84603797
23	Pancreatic cysts (HP:0001737)	2.80958638
24	Stomatitis (HP:0010280)	2.72334163
25	Panhypogammaglobulinemia (HP:0003139)	2.71553266
26	Hypothermia (HP:0002045)	2.69450121
27	Cerebellar dysplasia (HP:0007033)	2.68890604
28	Abnormality of midbrain morphology (HP:0002418)	2.66777234
29	Molar tooth sign on MRI (HP:0002419)	2.66777234
30	Cerebral edema (HP:0002181)	2.66001701
31	Optic disc pallor (HP:0000543)	2.57474436
32	Attenuation of retinal blood vessels (HP:0007843)	2.47433882
33	Testicular atrophy (HP:0000029)	2.46471364
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.45837060
35	Nephronophthisis (HP:0000090)	2.42917690
36	Increased serum lactate (HP:0002151)	2.37858476
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.35466311
38	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.25478730
39	Abnormality of the renal cortex (HP:0011035)	2.24663622
40	Hypoplasia of the uterus (HP:0000013)	2.23593643
41	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.22733322
42	Lactic acidosis (HP:0003128)	2.22335756
43	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.19590988
44	Abnormality of B cell number (HP:0010975)	2.18222196
45	Agammaglobulinemia (HP:0004432)	2.18145837
46	Renal Fanconi syndrome (HP:0001994)	2.16950403
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16860731
48	Abnormality of the renal medulla (HP:0100957)	2.16093552
49	Decreased central vision (HP:0007663)	2.15888154
50	Exertional dyspnea (HP:0002875)	2.15868519
51	Pancreatic fibrosis (HP:0100732)	2.12068853
52	Leukodystrophy (HP:0002415)	2.12040441
53	Prostate neoplasm (HP:0100787)	2.11790676
54	Azoospermia (HP:0000027)	2.11049946
55	Respiratory failure (HP:0002878)	2.10753140
56	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.07948709
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06829202
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.06829202
59	Methylmalonic acidemia (HP:0002912)	2.06537006
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06073357
61	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.04419335
62	Abnormal spermatogenesis (HP:0008669)	2.03749363
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03150878
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03150878
65	Abnormality of T cell physiology (HP:0011840)	2.02636180
66	Increased intramyocellular lipid droplets (HP:0012240)	2.01908180
67	Polydipsia (HP:0001959)	2.01035607
68	Abnormal drinking behavior (HP:0030082)	2.01035607
69	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.00692758
70	Severe combined immunodeficiency (HP:0004430)	1.99719498
71	Constricted visual fields (HP:0001133)	1.96961393
72	B lymphocytopenia (HP:0010976)	1.95054192
73	Abnormality of alanine metabolism (HP:0010916)	1.91723131
74	Hyperalaninemia (HP:0003348)	1.91723131
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91723131
76	Thyroiditis (HP:0100646)	1.89708417
77	Abnormal ciliary motility (HP:0012262)	1.88428390
78	Keratoconus (HP:0000563)	1.87342080
79	Increased corneal curvature (HP:0100692)	1.87342080
80	Abnormality of male internal genitalia (HP:0000022)	1.84953697
81	Lethargy (HP:0001254)	1.84380276
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.83982988
83	True hermaphroditism (HP:0010459)	1.83685454
84	Parakeratosis (HP:0001036)	1.83437826
85	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.83051795
86	Concave nail (HP:0001598)	1.83021334
87	Medial flaring of the eyebrow (HP:0010747)	1.81645014
88	Vasculitis (HP:0002633)	1.80568684
89	Type 2 muscle fiber atrophy (HP:0003554)	1.80405262
90	Renal cortical cysts (HP:0000803)	1.79729763
91	Alveolar cell carcinoma (HP:0006519)	1.79148053
92	Woolly hair (HP:0002224)	1.78786124
93	Visual hallucinations (HP:0002367)	1.76803870
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76677017
95	Abnormality of T cells (HP:0002843)	1.75896779
96	CNS demyelination (HP:0007305)	1.72262336
97	Adactyly (HP:0009776)	1.71739205
98	Increased muscle lipid content (HP:0009058)	1.70803883
99	Abnormality of secondary sexual hair (HP:0009888)	1.70029811
100	Abnormality of the axillary hair (HP:0100134)	1.70029811

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.45190525
2	TLK1	3.33180088
3	MAP4K2	3.29258987
4	ZAK	3.26116381
5	BMPR2	2.86216359
6	TXK	2.82212344
7	FRK	2.78581864
8	MAP3K12	2.49191980
9	CDK19	2.42176861
10	NUAK1	2.42101795
11	BMPR1B	2.32402236
12	ADRBK2	2.15682736
13	GRK1	1.94432024
14	BCKDK	1.88597134
15	KIT	1.82877901
16	OXSR1	1.76083530
17	MAP4K1	1.71419516
18	WNK4	1.70815110
19	CSF1R	1.69310890
20	MAP3K14	1.64295602
21	FLT3	1.52189520
22	IKBKB	1.37037413
23	MYLK	1.27151136
24	SYK	1.26668594
25	EIF2AK3	1.25470234
26	MST4	1.25299108
27	MKNK1	1.23132465
28	TEC	1.22997687
29	CDK8	1.18546000
30	FES	1.17128745
31	ITK	1.16865956
32	STK16	1.14595206
33	SCYL2	1.11391238
34	TGFBR1	1.08740766
35	TIE1	1.08600934
36	TRPM7	1.08537685
37	PHKG1	1.07727321
38	PHKG2	1.07727321
39	PINK1	1.07687617
40	MAPKAPK5	1.07648637
41	CSNK1G3	1.07006950
42	MAPK15	1.06643905
43	ERBB3	1.04952115
44	INSRR	1.03809632
45	VRK1	1.00643611
46	STK39	1.00267197
47	GRK7	0.99304512
48	EIF2AK1	0.98961949
49	PLK4	0.95493165
50	BTK	0.94945692
51	DAPK1	0.94466806
52	VRK2	0.92937939
53	LYN	0.92735654
54	RIPK4	0.87780117
55	CSNK1A1L	0.87724970
56	CSNK1G2	0.87003333
57	PLK2	0.86208677
58	GRK5	0.85966813
59	EIF2AK2	0.82589893
60	CSNK1G1	0.79078485
61	GRK6	0.74810865
62	DAPK2	0.72279164
63	JAK3	0.70978794
64	PIK3CA	0.70112046
65	RPS6KA5	0.68978521
66	MAP2K2	0.66293242
67	ACVR1B	0.66236761
68	MAPKAPK3	0.66214497
69	NEK1	0.63090727
70	LCK	0.62870613
71	MAP3K13	0.62658162
72	ADRBK1	0.62550098
73	PLK3	0.60776504
74	MAP3K4	0.60629240
75	WNK3	0.57017327
76	IGF1R	0.55665509
77	MAP2K6	0.55380993
78	PRKCQ	0.54167750
79	SRPK1	0.51129701
80	ILK	0.50897516
81	DAPK3	0.50620033
82	NME2	0.50572736
83	OBSCN	0.50520619
84	ABL1	0.48543450
85	DYRK2	0.47415035
86	CHUK	0.43722713
87	PIK3CG	0.42669648
88	PRKCE	0.41747208
89	TNK2	0.41184347
90	MKNK2	0.40752986
91	MAPK13	0.40026995
92	PKN1	0.39352076
93	ATR	0.38937539
94	CSNK1A1	0.36288865
95	KDR	0.34846992
96	PRKCA	0.34799944
97	PRKACA	0.32946084
98	CSNK2A2	0.32520800
99	AURKB	0.32412318
100	IKBKE	0.32251664

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.52498706
2	Allograft rejection_Homo sapiens_hsa05330	4.28288786
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.04564494
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.03442951
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.95324202
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.50541063
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64212578
8	Proteasome_Homo sapiens_hsa03050	2.50676712
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.50020327
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.44217538
11	Ribosome_Homo sapiens_hsa03010	2.20008253
12	Parkinsons disease_Homo sapiens_hsa05012	2.08577868
13	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.06558946
14	Caffeine metabolism_Homo sapiens_hsa00232	2.05373196
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.96365034
16	Viral myocarditis_Homo sapiens_hsa05416	1.95958667
17	Protein export_Homo sapiens_hsa03060	1.78685400
18	Leishmaniasis_Homo sapiens_hsa05140	1.63896402
19	RNA polymerase_Homo sapiens_hsa03020	1.55552942
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.41848620
21	Phototransduction_Homo sapiens_hsa04744	1.41715363
22	Alzheimers disease_Homo sapiens_hsa05010	1.36726862
23	Homologous recombination_Homo sapiens_hsa03440	1.34841559
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.28907624
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.27791050
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25138642
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22866305
28	Huntingtons disease_Homo sapiens_hsa05016	1.22651469
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.22626925
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15803835
31	RNA degradation_Homo sapiens_hsa03018	1.14510815
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13051052
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98348655
34	One carbon pool by folate_Homo sapiens_hsa00670	0.96246389
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.92134030
36	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90062390
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83587176
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82570572
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.80517645
40	Mismatch repair_Homo sapiens_hsa03430	0.79755242
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.79512901
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75345535
43	Toxoplasmosis_Homo sapiens_hsa05145	0.74776776
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.73010746
45	Olfactory transduction_Homo sapiens_hsa04740	0.71648508
46	Regulation of autophagy_Homo sapiens_hsa04140	0.69865054
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69406879
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68845544
49	Basal transcription factors_Homo sapiens_hsa03022	0.68286232
50	Herpes simplex infection_Homo sapiens_hsa05168	0.67331179
51	Purine metabolism_Homo sapiens_hsa00230	0.66316622
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64318977
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63666262
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62353871
55	Spliceosome_Homo sapiens_hsa03040	0.60309242
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60094813
57	Tuberculosis_Homo sapiens_hsa05152	0.59081781
58	Propanoate metabolism_Homo sapiens_hsa00640	0.54185661
59	DNA replication_Homo sapiens_hsa03030	0.53354159
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.50843034
61	Peroxisome_Homo sapiens_hsa04146	0.49133738
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48706635
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48643584
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48118168
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47816000
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46946692
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46201624
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44286320
69	Phagosome_Homo sapiens_hsa04145	0.43645826
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43552432
71	Influenza A_Homo sapiens_hsa05164	0.40546081
72	Base excision repair_Homo sapiens_hsa03410	0.40123557
73	RNA transport_Homo sapiens_hsa03013	0.39543631
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38862146
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37752297
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37188417
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36505497
78	Retinol metabolism_Homo sapiens_hsa00830	0.35355200
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.34561998
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.34108999
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32886167
82	Salivary secretion_Homo sapiens_hsa04970	0.32169320
83	Butanoate metabolism_Homo sapiens_hsa00650	0.31269862
84	Metabolic pathways_Homo sapiens_hsa01100	0.30791687
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29943038
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29723561
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29610470
88	Nicotine addiction_Homo sapiens_hsa05033	0.28766993
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28745216
90	Taste transduction_Homo sapiens_hsa04742	0.28305999
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26601366
92	Sulfur metabolism_Homo sapiens_hsa00920	0.26354513
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24621959
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22284198
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.19197918
96	Morphine addiction_Homo sapiens_hsa05032	0.18342890
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.15293387
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15176692
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.13018928
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.11383228

RPL7P51

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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