RPL7P52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lactate metabolic process (GO:0006089)4.78129498
2response to pheromone (GO:0019236)4.66199720
3DNA deamination (GO:0045006)3.71952607
4water-soluble vitamin biosynthetic process (GO:0042364)3.64050527
5cytochrome complex assembly (GO:0017004)3.61560791
6indole-containing compound catabolic process (GO:0042436)3.54628172
7indolalkylamine catabolic process (GO:0046218)3.54628172
8tryptophan catabolic process (GO:0006569)3.54628172
9neural tube formation (GO:0001841)3.45752286
10indolalkylamine metabolic process (GO:0006586)3.41563156
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38142999
12ATP synthesis coupled proton transport (GO:0015986)3.38142999
13protein complex biogenesis (GO:0070271)3.38056030
14S-adenosylmethionine metabolic process (GO:0046500)3.37103011
15peptidyl-histidine modification (GO:0018202)3.36677680
16tryptophan metabolic process (GO:0006568)3.32167923
17DNA double-strand break processing (GO:0000729)3.30144873
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29720385
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26461007
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.26377882
21kynurenine metabolic process (GO:0070189)3.26251324
22protein neddylation (GO:0045116)3.25247790
23respiratory chain complex IV assembly (GO:0008535)3.23922981
24platelet dense granule organization (GO:0060155)3.19946512
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19795248
26behavioral response to nicotine (GO:0035095)3.19604680
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16968972
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16968972
29axoneme assembly (GO:0035082)3.14386750
30adaptation of signaling pathway (GO:0023058)3.13877375
31mitochondrial respiratory chain complex assembly (GO:0033108)3.11747148
32regulation of cilium movement (GO:0003352)3.08414973
33kidney morphogenesis (GO:0060993)3.07352605
34signal peptide processing (GO:0006465)3.07227031
35positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.02866022
36regulation of hexokinase activity (GO:1903299)3.01307714
37regulation of glucokinase activity (GO:0033131)3.01307714
38proteasome assembly (GO:0043248)2.99069935
39cellular ketone body metabolic process (GO:0046950)2.97708852
40GPI anchor metabolic process (GO:0006505)2.95310535
41preassembly of GPI anchor in ER membrane (GO:0016254)2.93470716
42negative regulation of telomere maintenance (GO:0032205)2.93361140
43termination of RNA polymerase III transcription (GO:0006386)2.90795381
44transcription elongation from RNA polymerase III promoter (GO:0006385)2.90795381
45prenylation (GO:0097354)2.88255770
46protein prenylation (GO:0018342)2.88255770
47fucose catabolic process (GO:0019317)2.88213035
48L-fucose metabolic process (GO:0042354)2.88213035
49L-fucose catabolic process (GO:0042355)2.88213035
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87305219
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85391731
52negative regulation of execution phase of apoptosis (GO:1900118)2.85001185
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80473323
54establishment of protein localization to Golgi (GO:0072600)2.79290488
55epithelial cilium movement (GO:0003351)2.78819317
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75692380
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74216298
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73201204
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73201204
60isotype switching (GO:0045190)2.73201204
61protein targeting to Golgi (GO:0000042)2.69681176
62GPI anchor biosynthetic process (GO:0006506)2.66241003
63positive regulation of glycolytic process (GO:0045821)2.63657356
64ketone body metabolic process (GO:1902224)2.63120662
65retinal cone cell development (GO:0046549)2.63119671
66regulation of telomere maintenance (GO:0032204)2.63049609
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.61821694
68dopamine transport (GO:0015872)2.61060012
69intraciliary transport (GO:0042073)2.60935198
70L-methionine salvage (GO:0071267)2.57269023
71L-methionine biosynthetic process (GO:0071265)2.57269023
72amino acid salvage (GO:0043102)2.57269023
73male meiosis (GO:0007140)2.53824783
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52972510
75photoreceptor cell maintenance (GO:0045494)2.50540285
76C-terminal protein amino acid modification (GO:0018410)2.50363854
77mannosylation (GO:0097502)2.50319090
78regulation of action potential (GO:0098900)2.50068134
79regulation of cellular amino acid metabolic process (GO:0006521)2.49919998
80ubiquinone metabolic process (GO:0006743)2.49602016
81adenosine metabolic process (GO:0046085)2.48512544
82detection of light stimulus involved in visual perception (GO:0050908)2.47461661
83detection of light stimulus involved in sensory perception (GO:0050962)2.47461661
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45905267
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45905267
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45905267
87replication fork processing (GO:0031297)2.44075257
88cellular biogenic amine catabolic process (GO:0042402)2.41793576
89amine catabolic process (GO:0009310)2.41793576
90protein localization to Golgi apparatus (GO:0034067)2.41043704
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40648557
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40648557
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.40248172
94ubiquinone biosynthetic process (GO:0006744)2.40156683
95negative regulation of JUN kinase activity (GO:0043508)2.39498700
96C-terminal protein lipidation (GO:0006501)2.39174188
97intestinal epithelial cell development (GO:0060576)2.39161884
98regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.36993814
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.36357203
100indole-containing compound metabolic process (GO:0042430)2.35723110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45505344
2ZNF274_21170338_ChIP-Seq_K562_Hela3.32069510
3VDR_22108803_ChIP-Seq_LS180_Human2.86906382
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74387728
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.71844617
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67435254
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.55328029
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46158992
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.26112340
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21769691
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21033445
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16984926
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16925776
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15702054
15GBX2_23144817_ChIP-Seq_PC3_Human2.12093887
16IGF1R_20145208_ChIP-Seq_DFB_Human2.11211367
17ELK1_19687146_ChIP-ChIP_HELA_Human2.09183258
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.99430373
19EWS_26573619_Chip-Seq_HEK293_Human1.90532909
20P300_19829295_ChIP-Seq_ESCs_Human1.90043117
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87027708
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85487519
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81378280
24FUS_26573619_Chip-Seq_HEK293_Human1.80121909
25ER_23166858_ChIP-Seq_MCF-7_Human1.79275975
26TAF15_26573619_Chip-Seq_HEK293_Human1.77069670
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73953598
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69942688
29BCAT_22108803_ChIP-Seq_LS180_Human1.66491761
30CBP_20019798_ChIP-Seq_JUKART_Human1.65977703
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65977703
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64846232
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64377019
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.64005098
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.63264247
36VDR_23849224_ChIP-Seq_CD4+_Human1.61908413
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60568252
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56284299
39NANOG_19829295_ChIP-Seq_ESCs_Human1.55774626
40SOX2_19829295_ChIP-Seq_ESCs_Human1.55774626
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.54446193
42TP53_22573176_ChIP-Seq_HFKS_Human1.53680124
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52594520
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47269868
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46879033
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.42109046
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41870767
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39788903
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.39505341
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.35475991
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35075734
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34765908
53FOXP3_21729870_ChIP-Seq_TREG_Human1.33250537
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31084616
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.31084616
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30824004
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30576590
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29760538
59CDX2_22108803_ChIP-Seq_LS180_Human1.29566120
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29324463
61TCF4_22108803_ChIP-Seq_LS180_Human1.27952141
62AR_25329375_ChIP-Seq_VCAP_Human1.26624577
63P53_22387025_ChIP-Seq_ESCs_Mouse1.26610748
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26472706
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24595558
66SMAD4_21799915_ChIP-Seq_A2780_Human1.23512030
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.23454128
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.23078130
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22973999
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22022199
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.21128537
72P300_18555785_Chip-Seq_ESCs_Mouse1.20695069
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19365691
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.19053969
75AR_20517297_ChIP-Seq_VCAP_Human1.18895365
76MYC_18940864_ChIP-ChIP_HL60_Human1.18108890
77HTT_18923047_ChIP-ChIP_STHdh_Human1.17971674
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17594868
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17350547
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17186536
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.16306385
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16258512
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15913660
84IRF1_19129219_ChIP-ChIP_H3396_Human1.15682728
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.14471194
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14277996
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14024146
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.13743000
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13302660
90TCF4_23295773_ChIP-Seq_U87_Human1.10498154
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.10271888
92STAT3_23295773_ChIP-Seq_U87_Human1.10076935
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08687949
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.08657761
95PHF8_20622853_ChIP-Seq_HELA_Human1.07131751
96NCOR_22424771_ChIP-Seq_293T_Human1.07081182
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07017960
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06830199
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06036880
100RBPJ_21746931_ChIP-Seq_IB4_Human1.05470420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.16333115
2MP0003787_abnormal_imprinting3.12535031
3MP0008877_abnormal_DNA_methylation3.02205827
4MP0000372_irregular_coat_pigmentation2.86031940
5MP0002102_abnormal_ear_morphology2.81679086
6MP0002163_abnormal_gland_morphology2.67483485
7MP0005379_endocrine/exocrine_gland_phen2.62465639
8MP0003283_abnormal_digestive_organ2.46072866
9MP0001984_abnormal_olfaction2.40167280
10MP0002837_dystrophic_cardiac_calcinosis2.28131129
11MP0002876_abnormal_thyroid_physiology2.27165992
12MP0006072_abnormal_retinal_apoptosis2.19886415
13MP0008872_abnormal_physiological_respon2.16015663
14MP0003195_calcinosis2.12611896
15MP0001529_abnormal_vocalization2.10664260
16MP0003122_maternal_imprinting2.10518411
17MP0005253_abnormal_eye_physiology2.09200291
18MP0002638_abnormal_pupillary_reflex2.04823287
19MP0005075_abnormal_melanosome_morpholog2.04354942
20MP0010386_abnormal_urinary_bladder1.95977565
21MP0008875_abnormal_xenobiotic_pharmacok1.80139680
22MP0003121_genomic_imprinting1.75993726
23MP0003880_abnormal_central_pattern1.75392719
24MP0005551_abnormal_eye_electrophysiolog1.72219616
25MP0008995_early_reproductive_senescence1.71413027
26MP0001986_abnormal_taste_sensitivity1.70484328
27MP0003011_delayed_dark_adaptation1.63271758
28MP0004043_abnormal_pH_regulation1.57325535
29MP0009697_abnormal_copulation1.57103692
30MP0005646_abnormal_pituitary_gland1.56571452
31MP0005671_abnormal_response_to1.54224648
32MP0002909_abnormal_adrenal_gland1.52103656
33MP0005645_abnormal_hypothalamus_physiol1.46875715
34MP0001764_abnormal_homeostasis1.44545560
35MP0005084_abnormal_gallbladder_morpholo1.40386396
36MP0003786_premature_aging1.40014168
37MP0000569_abnormal_digit_pigmentation1.35387759
38MP0002938_white_spotting1.34763114
39MP0005636_abnormal_mineral_homeostasis1.33270035
40MP0002166_altered_tumor_susceptibility1.29959291
41MP0004215_abnormal_myocardial_fiber1.27109256
42MP0002693_abnormal_pancreas_physiology1.25946344
43MP0006054_spinal_hemorrhage1.25648337
44MP0006036_abnormal_mitochondrial_physio1.22146978
45MP0001968_abnormal_touch/_nociception1.22121285
46MP0001835_abnormal_antigen_presentation1.19245716
47MP0003718_maternal_effect1.16913538
48MP0005367_renal/urinary_system_phenotyp1.14507990
49MP0000516_abnormal_urinary_system1.14507990
50MP0006292_abnormal_olfactory_placode1.11594093
51MP0003186_abnormal_redox_activity1.11367591
52MP0001919_abnormal_reproductive_system1.07882746
53MP0000427_abnormal_hair_cycle1.07754236
54MP0001944_abnormal_pancreas_morphology1.07114502
55MP0004484_altered_response_of1.06049302
56MP0002138_abnormal_hepatobiliary_system1.05210167
57MP0001501_abnormal_sleep_pattern1.01128400
58MP0009046_muscle_twitch0.98281436
59MP0002751_abnormal_autonomic_nervous0.98246913
60MP0004142_abnormal_muscle_tone0.96883709
61MP0009745_abnormal_behavioral_response0.96873313
62MP0005389_reproductive_system_phenotype0.96111143
63MP0000631_abnormal_neuroendocrine_gland0.96012336
64MP0005503_abnormal_tendon_morphology0.93134208
65MP0005332_abnormal_amino_acid0.92201636
66MP0000613_abnormal_salivary_gland0.92023443
67MP0002090_abnormal_vision0.91749990
68MP0005410_abnormal_fertilization0.90688861
69MP0002006_tumorigenesis0.90566474
70MP0002272_abnormal_nervous_system0.90463652
71MP0004084_abnormal_cardiac_muscle0.90227670
72MP0002736_abnormal_nociception_after0.88769543
73MP0008775_abnormal_heart_ventricle0.88176547
74MP0003172_abnormal_lysosome_physiology0.86730418
75MP0001970_abnormal_pain_threshold0.86637579
76MP0005174_abnormal_tail_pigmentation0.84888781
77MP0004147_increased_porphyrin_level0.84604800
78MP0001756_abnormal_urination0.83339112
79MP0004924_abnormal_behavior0.83075544
80MP0005386_behavior/neurological_phenoty0.83075544
81MP0000015_abnormal_ear_pigmentation0.81269344
82MP0006276_abnormal_autonomic_nervous0.80233976
83MP0008007_abnormal_cellular_replicative0.80201194
84MP0000383_abnormal_hair_follicle0.80135289
85MP0003252_abnormal_bile_duct0.78753357
86MP0001485_abnormal_pinna_reflex0.78103370
87MP0000538_abnormal_urinary_bladder0.77324588
88MP0001486_abnormal_startle_reflex0.76334332
89MP0002277_abnormal_respiratory_mucosa0.75567392
90MP0004885_abnormal_endolymph0.72932513
91MP0008789_abnormal_olfactory_epithelium0.72020537
92MP0001929_abnormal_gametogenesis0.71385592
93MP0000647_abnormal_sebaceous_gland0.71118526
94MP0001765_abnormal_ion_homeostasis0.70609861
95MP0001502_abnormal_circadian_rhythm0.69388002
96MP0004134_abnormal_chest_morphology0.68997957
97MP0009785_altered_susceptibility_to0.68900198
98MP0005365_abnormal_bile_salt0.68421415
99MP0000653_abnormal_sex_gland0.67653345
100MP0004019_abnormal_vitamin_homeostasis0.67239612

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)3.62230977
2Pancreatic cysts (HP:0001737)3.51384191
3Pancreatic islet-cell hyperplasia (HP:0004510)3.35252373
4Abnormality of midbrain morphology (HP:0002418)3.27586188
5Molar tooth sign on MRI (HP:0002419)3.27586188
6Large for gestational age (HP:0001520)3.10580654
7Pancreatic fibrosis (HP:0100732)3.07596926
8Methylmalonic acidemia (HP:0002912)3.04836258
9Acute necrotizing encephalopathy (HP:0006965)3.03493625
10Hypoglycemic seizures (HP:0002173)3.03346474
11Progressive macrocephaly (HP:0004481)3.02453902
12Congenital stationary night blindness (HP:0007642)2.98437770
13Abnormality of the renal cortex (HP:0011035)2.98056754
14Ketoacidosis (HP:0001993)2.91062597
15Hyperglycemia (HP:0003074)2.86190974
16Stomatitis (HP:0010280)2.79276718
17Congenital, generalized hypertrichosis (HP:0004540)2.76739534
18Renal cortical cysts (HP:0000803)2.76231838
19True hermaphroditism (HP:0010459)2.74069443
20Hypothermia (HP:0002045)2.73935928
21Mitochondrial inheritance (HP:0001427)2.73267008
22Cerebellar dysplasia (HP:0007033)2.64900621
23Acute encephalopathy (HP:0006846)2.64422515
24Increased CSF lactate (HP:0002490)2.63462991
25Nephronophthisis (HP:0000090)2.61440490
26Type II lissencephaly (HP:0007260)2.56483620
27Medial flaring of the eyebrow (HP:0010747)2.54586967
28Methylmalonic aciduria (HP:0012120)2.52938178
29Hypoglycemic coma (HP:0001325)2.49379064
30Attenuation of retinal blood vessels (HP:0007843)2.44750575
31Hypoproteinemia (HP:0003075)2.43790845
32Abnormality of B cell number (HP:0010975)2.42316403
33Abnormal rod and cone electroretinograms (HP:0008323)2.42142165
34Abnormality of endocrine pancreas physiology (HP:0012093)2.42007405
35Abnormality of the pancreatic islet cells (HP:0006476)2.42007405
36Thyroiditis (HP:0100646)2.40634617
37Bile duct proliferation (HP:0001408)2.34594741
38Abnormal biliary tract physiology (HP:0012439)2.34594741
39Abnormality of the renal medulla (HP:0100957)2.32254739
40Abolished electroretinogram (ERG) (HP:0000550)2.31733851
41Abnormal mitochondria in muscle tissue (HP:0008316)2.28332578
42Hepatocellular necrosis (HP:0001404)2.21948505
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.17075737
44Abnormality of the metopic suture (HP:0005556)2.15670203
45Abnormality of the labia minora (HP:0012880)2.13395237
46Prominent metopic ridge (HP:0005487)2.11052885
47Increased hepatocellular lipid droplets (HP:0006565)2.10392529
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.07820604
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07150158
50Lipid accumulation in hepatocytes (HP:0006561)2.06221631
51Abnormality of vitamin B metabolism (HP:0004340)2.06171372
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05885162
53Ketosis (HP:0001946)2.05360686
54Insulin-resistant diabetes mellitus (HP:0000831)2.03873131
55Abnormal drinking behavior (HP:0030082)2.01328730
56Polydipsia (HP:0001959)2.01328730
57Optic disc pallor (HP:0000543)2.00090321
58Stomach cancer (HP:0012126)1.99724787
59Meckel diverticulum (HP:0002245)1.97767525
60Male pseudohermaphroditism (HP:0000037)1.97274537
61Asplenia (HP:0001746)1.97013202
62Inability to walk (HP:0002540)1.95341245
63Supernumerary spleens (HP:0009799)1.95211129
64Symptomatic seizures (HP:0011145)1.93374478
65Intestinal atresia (HP:0011100)1.93076240
66Aplasia/hypoplasia of the uterus (HP:0008684)1.92984343
67Abnormality of the ileum (HP:0001549)1.92971012
68Hepatic necrosis (HP:0002605)1.92942613
69Progressive inability to walk (HP:0002505)1.92737857
70Cerebral edema (HP:0002181)1.92086490
71Decreased central vision (HP:0007663)1.89850544
72Cystic liver disease (HP:0006706)1.88946299
73Delayed CNS myelination (HP:0002188)1.86064260
74IgG deficiency (HP:0004315)1.86021305
75B lymphocytopenia (HP:0010976)1.85097481
76Abnormality of macular pigmentation (HP:0008002)1.84802559
773-Methylglutaconic aciduria (HP:0003535)1.84575691
78Type I transferrin isoform profile (HP:0003642)1.82301365
79Gaze-evoked nystagmus (HP:0000640)1.80555407
80Severe combined immunodeficiency (HP:0004430)1.78008292
81Poor suck (HP:0002033)1.77958474
82Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77549267
83Absent thumb (HP:0009777)1.77394252
84Furrowed tongue (HP:0000221)1.76736643
85Constricted visual fields (HP:0001133)1.75131150
86Chronic hepatic failure (HP:0100626)1.73662204
87Narrow forehead (HP:0000341)1.73493676
88Decreased circulating renin level (HP:0003351)1.73426630
89Hypomagnesemia (HP:0002917)1.72811819
90Polyuria (HP:0000103)1.71999168
91Adrenal hypoplasia (HP:0000835)1.70209524
92Increased serum lactate (HP:0002151)1.69895667
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.69556082
94Sensory axonal neuropathy (HP:0003390)1.68277443
95Lactic acidosis (HP:0003128)1.67652081
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.66214771
97Keratoconus (HP:0000563)1.65278223
98Increased corneal curvature (HP:0100692)1.65278223
99Absent/shortened dynein arms (HP:0200106)1.65090600
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.65090600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.57837435
2NUAK13.24765587
3MAP4K23.09437489
4TRIM283.01318110
5MST42.83519943
6ADRBK22.62331896
7ZAK2.44957451
8WNK32.39750002
9BRSK22.10124152
10GRK12.09627767
11PINK11.84098486
12EIF2AK31.72913625
13INSRR1.65348840
14PAK31.62037149
15TXK1.61331304
16TLK11.60654471
17PLK31.55030731
18WEE11.52133717
19BMPR1B1.44771367
20MKNK21.40193454
21VRK21.38539966
22PLK21.37832712
23OXSR11.36970101
24BCR1.33105495
25MAP3K121.29604407
26CAMKK21.27426906
27EIF2AK11.24549533
28SRPK11.23433754
29NEK11.19825028
30AKT31.18908688
31VRK11.17631738
32TNIK1.17411696
33MAP3K41.17029152
34NLK1.15028991
35BCKDK1.12619553
36ERBB31.10402719
37PBK1.10326642
38FGFR21.07724716
39STK391.07369555
40TAOK31.06238007
41SIK31.04223712
42WNK41.01987032
43TAF11.01878578
44STK161.01641463
45TRPM70.99012743
46DAPK20.97614145
47PASK0.96118637
48BMPR20.95710482
49TSSK60.88188080
50PRKCE0.88066582
51CSNK1G10.85289443
52MAPK130.84191449
53STK30.83304320
54PNCK0.81151023
55MKNK10.79798283
56PHKG10.77575515
57PHKG20.77575515
58PIK3CG0.77023840
59STK240.75324548
60ACVR1B0.74102048
61TEC0.71343924
62TNK20.71273523
63MAP3K20.71234265
64STK38L0.70649502
65CAMK2D0.70088655
66MYLK0.67155266
67EIF2AK20.65215049
68FER0.63748619
69PTK2B0.63410716
70IKBKB0.61944442
71CSNK1G20.61376421
72MAP2K60.58807731
73ITK0.57409227
74CSNK1G30.55760049
75ILK0.55646648
76TIE10.55563439
77PRKCQ0.53265691
78ERBB20.53184886
79ADRBK10.51595475
80PRKCI0.51269939
81PRKCG0.46496933
82CDK190.44199801
83CSNK1A1L0.43946230
84KIT0.43560732
85NTRK20.41693136
86BRSK10.41658633
87DAPK10.40125373
88FES0.38632318
89OBSCN0.37405601
90PIK3CA0.37091308
91PRKAA20.34460733
92PRKACA0.34047427
93BUB10.32687157
94WNK10.31986955
95DYRK20.31877549
96CSNK1D0.30670139
97IRAK10.30036476
98PLK10.29437458
99RPS6KA50.29126373
100FLT30.28868959

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.00342003
2Proteasome_Homo sapiens_hsa030503.49352595
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93591368
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.68992162
5Oxidative phosphorylation_Homo sapiens_hsa001902.64540080
6Asthma_Homo sapiens_hsa053102.44235360
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38331222
8Phototransduction_Homo sapiens_hsa047442.28956956
9RNA polymerase_Homo sapiens_hsa030202.17048846
10Caffeine metabolism_Homo sapiens_hsa002322.15521882
11Parkinsons disease_Homo sapiens_hsa050122.07730725
12Nitrogen metabolism_Homo sapiens_hsa009102.07060447
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.03104366
14Allograft rejection_Homo sapiens_hsa053302.01713761
15Type I diabetes mellitus_Homo sapiens_hsa049401.92439842
16Basal transcription factors_Homo sapiens_hsa030221.91812131
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77200998
18Butanoate metabolism_Homo sapiens_hsa006501.75923498
19Propanoate metabolism_Homo sapiens_hsa006401.71652392
20Autoimmune thyroid disease_Homo sapiens_hsa053201.71561343
21RNA degradation_Homo sapiens_hsa030181.71243999
22Sulfur metabolism_Homo sapiens_hsa009201.68831561
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68706818
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62015174
25Non-homologous end-joining_Homo sapiens_hsa034501.57806989
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52734451
27Fanconi anemia pathway_Homo sapiens_hsa034601.50546961
28Homologous recombination_Homo sapiens_hsa034401.47534356
29Linoleic acid metabolism_Homo sapiens_hsa005911.46369034
30Graft-versus-host disease_Homo sapiens_hsa053321.43866589
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38624111
32Circadian rhythm_Homo sapiens_hsa047101.33399278
33Tryptophan metabolism_Homo sapiens_hsa003801.31871220
34Peroxisome_Homo sapiens_hsa041461.27398584
35One carbon pool by folate_Homo sapiens_hsa006701.25846323
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23707027
37Huntingtons disease_Homo sapiens_hsa050161.23165796
38Alzheimers disease_Homo sapiens_hsa050101.16742763
39Ether lipid metabolism_Homo sapiens_hsa005651.11174700
40Regulation of autophagy_Homo sapiens_hsa041401.10150949
41Selenocompound metabolism_Homo sapiens_hsa004501.06581072
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.05313038
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05193955
44Primary immunodeficiency_Homo sapiens_hsa053400.99495274
45Insulin secretion_Homo sapiens_hsa049110.98935645
46Olfactory transduction_Homo sapiens_hsa047400.96963602
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95104806
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93593413
49Collecting duct acid secretion_Homo sapiens_hsa049660.92452662
50Purine metabolism_Homo sapiens_hsa002300.91473315
51Vitamin B6 metabolism_Homo sapiens_hsa007500.89512073
52Rheumatoid arthritis_Homo sapiens_hsa053230.89312916
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86893531
54ABC transporters_Homo sapiens_hsa020100.86716081
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85744698
56RNA transport_Homo sapiens_hsa030130.84590600
57Chemical carcinogenesis_Homo sapiens_hsa052040.83311689
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79122557
59Antigen processing and presentation_Homo sapiens_hsa046120.78414296
60Cardiac muscle contraction_Homo sapiens_hsa042600.77322812
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76561471
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74905526
63Taste transduction_Homo sapiens_hsa047420.72869024
64Arachidonic acid metabolism_Homo sapiens_hsa005900.71881146
65Retinol metabolism_Homo sapiens_hsa008300.71499332
66Pyrimidine metabolism_Homo sapiens_hsa002400.62399775
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59799546
68Mineral absorption_Homo sapiens_hsa049780.56319011
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55827946
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.55248628
71Metabolic pathways_Homo sapiens_hsa011000.54698143
72Salivary secretion_Homo sapiens_hsa049700.52881858
73Steroid biosynthesis_Homo sapiens_hsa001000.51584494
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51556028
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.51226696
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50270913
77Fat digestion and absorption_Homo sapiens_hsa049750.46755256
78Spliceosome_Homo sapiens_hsa030400.44730380
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43258267
80Circadian entrainment_Homo sapiens_hsa047130.42185657
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39431387
82Renin secretion_Homo sapiens_hsa049240.37104738
83Oocyte meiosis_Homo sapiens_hsa041140.34441360
84Fatty acid elongation_Homo sapiens_hsa000620.31702835
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30725545
86Serotonergic synapse_Homo sapiens_hsa047260.30184421
87Nicotine addiction_Homo sapiens_hsa050330.29815567
88Morphine addiction_Homo sapiens_hsa050320.28649735
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27491271
90Glutathione metabolism_Homo sapiens_hsa004800.27245592
91Ribosome_Homo sapiens_hsa030100.26340447
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26215231
93Hedgehog signaling pathway_Homo sapiens_hsa043400.25236789
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25039072
95African trypanosomiasis_Homo sapiens_hsa051430.24937551
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24785708
97Hematopoietic cell lineage_Homo sapiens_hsa046400.23761762
98Sphingolipid metabolism_Homo sapiens_hsa006000.23533839
99Ovarian steroidogenesis_Homo sapiens_hsa049130.22283038
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.18707968

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