ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	6.87740520
2	substrate-independent telencephalic tangential migration (GO:0021826)	6.87740520
3	DNA deamination (GO:0045006)	6.09645329
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.75480402
5	glyoxylate metabolic process (GO:0046487)	4.46919041
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.30131776
7	L-phenylalanine catabolic process (GO:0006559)	4.30131776
8	response to pheromone (GO:0019236)	4.25252832
9	positive regulation of mitochondrial fission (GO:0090141)	4.23614666
10	behavioral response to nicotine (GO:0035095)	4.21501783
11	seminiferous tubule development (GO:0072520)	4.04325548
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.87546361
13	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.85432574
14	piRNA metabolic process (GO:0034587)	3.83629664
15	cell wall macromolecule catabolic process (GO:0016998)	3.82175953
16	cerebral cortex radially oriented cell migration (GO:0021799)	3.81067885
17	cytidine deamination (GO:0009972)	3.81050695
18	cytidine metabolic process (GO:0046087)	3.81050695
19	cytidine catabolic process (GO:0006216)	3.81050695
20	isotype switching (GO:0045190)	3.80304282
21	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.80304282
22	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.80304282
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79673196
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.76023287
25	aldehyde catabolic process (GO:0046185)	3.64548907
26	L-phenylalanine metabolic process (GO:0006558)	3.63521658
27	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.63521658
28	protein-cofactor linkage (GO:0018065)	3.63075497
29	pattern specification involved in kidney development (GO:0061004)	3.59919385
30	xenobiotic catabolic process (GO:0042178)	3.52756941
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.48092430
32	NADH dehydrogenase complex assembly (GO:0010257)	3.48092430
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.48092430
34	GTP biosynthetic process (GO:0006183)	3.44417245
35	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.42857527
36	ribosomal small subunit assembly (GO:0000028)	3.36377810
37	proteasome assembly (GO:0043248)	3.30077391
38	preassembly of GPI anchor in ER membrane (GO:0016254)	3.29418590
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29260777
40	protein complex biogenesis (GO:0070271)	3.29069924
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.29040006
42	branched-chain amino acid metabolic process (GO:0009081)	3.17131114
43	cell wall macromolecule metabolic process (GO:0044036)	3.15652945
44	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.14350783
45	sodium-independent organic anion transport (GO:0043252)	3.13763149
46	mannosylation (GO:0097502)	3.13623992
47	regulation of mitochondrial translation (GO:0070129)	3.10760407
48	male meiosis I (GO:0007141)	3.09373316
49	alkaloid metabolic process (GO:0009820)	3.07897358
50	serine family amino acid catabolic process (GO:0009071)	3.07660553
51	UTP biosynthetic process (GO:0006228)	3.06473125
52	branched-chain amino acid catabolic process (GO:0009083)	3.03757285
53	arginine catabolic process (GO:0006527)	3.03025959
54	regulation of mitochondrial fission (GO:0090140)	3.01994340
55	regulation of triglyceride catabolic process (GO:0010896)	3.00397959
56	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.98997333
57	CTP metabolic process (GO:0046036)	2.97841434
58	CTP biosynthetic process (GO:0006241)	2.97841434
59	head development (GO:0060322)	2.97702927
60	microtubule severing (GO:0051013)	2.95206790
61	positive regulation of prostaglandin secretion (GO:0032308)	2.92880121
62	termination of RNA polymerase III transcription (GO:0006386)	2.91741090
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.91741090
64	glycine metabolic process (GO:0006544)	2.90784198
65	DNA methylation involved in gamete generation (GO:0043046)	2.90374379
66	drug catabolic process (GO:0042737)	2.88432685
67	aromatic amino acid family catabolic process (GO:0009074)	2.86852618
68	maturation of 5.8S rRNA (GO:0000460)	2.83594541
69	pantothenate metabolic process (GO:0015939)	2.83016887
70	UTP metabolic process (GO:0046051)	2.81978923
71	L-ascorbic acid metabolic process (GO:0019852)	2.81044141
72	meiotic chromosome segregation (GO:0045132)	2.78172078
73	oxidative demethylation (GO:0070989)	2.77029688
74	nonmotile primary cilium assembly (GO:0035058)	2.75183159
75	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.73024892
76	polyketide metabolic process (GO:0030638)	2.72630153
77	doxorubicin metabolic process (GO:0044598)	2.72630153
78	daunorubicin metabolic process (GO:0044597)	2.72630153
79	resolution of meiotic recombination intermediates (GO:0000712)	2.70932300
80	valine metabolic process (GO:0006573)	2.69957806
81	hormone catabolic process (GO:0042447)	2.67919259
82	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67030843
83	response to nitrosative stress (GO:0051409)	2.66750472
84	thyroid hormone generation (GO:0006590)	2.62561021
85	coenzyme catabolic process (GO:0009109)	2.61403375
86	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.61084554
87	ATP synthesis coupled proton transport (GO:0015986)	2.61084554
88	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.58649501
89	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.56736967
90	pyrimidine nucleobase catabolic process (GO:0006208)	2.56648524
91	meiosis I (GO:0007127)	2.51889014
92	epithelial cilium movement (GO:0003351)	2.51411175
93	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.50604370
94	regulation of sequestering of triglyceride (GO:0010889)	2.49743458
95	arginine metabolic process (GO:0006525)	2.49042507
96	translational termination (GO:0006415)	2.48187886
97	viral transcription (GO:0019083)	2.47597497
98	cytochrome complex assembly (GO:0017004)	2.47138018
99	rRNA modification (GO:0000154)	2.46774290
100	oocyte maturation (GO:0001556)	2.46243172

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.80615270
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.56067904
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.34164309
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.16275315
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.99320288
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74592691
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.60030061
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48992070
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.40121357
10	VDR_22108803_ChIP-Seq_LS180_Human	2.27618173
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24033043
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.23146101
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16290965
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.14679937
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.12256019
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99315658
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97622324
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.87826820
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84981193
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73895080
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.69381274
22	EWS_26573619_Chip-Seq_HEK293_Human	1.65187272
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63690882
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62517256
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59780407
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.56464572
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54750522
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53310330
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52916527
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.49980972
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47364101
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46808340
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46165303
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42740970
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.40741152
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37094016
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36576409
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36255065
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35173568
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.34096426
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.31296176
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30496705
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29572671
44	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.29207318
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28721002
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28696099
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25086703
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21639435
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20269773
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.19820785
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19700049
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18862793
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18404922
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18404922
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17556858
56	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17334637
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16414892
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16414892
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.15692003
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13948382
61	FUS_26573619_Chip-Seq_HEK293_Human	1.13019405
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12309390
63	P300_19829295_ChIP-Seq_ESCs_Human	1.11687028
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11599623
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11466206
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10458369
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.09944621
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09267343
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04990483
70	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04156222
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.03320896
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03320896
73	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.03247152
74	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03173868
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03056518
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02643654
77	AR_20517297_ChIP-Seq_VCAP_Human	1.02223331
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01885375
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98941122
80	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97022178
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96389567
82	GATA3_26560356_Chip-Seq_TH1_Human	0.95886521
83	ER_23166858_ChIP-Seq_MCF-7_Human	0.95155379
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.94311179
85	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94276511
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.94225921
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94053541
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.93901611
89	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93779773
90	GATA3_26560356_Chip-Seq_TH2_Human	0.93531520
91	NCOR_22424771_ChIP-Seq_293T_Human	0.93455004
92	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92214718
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91915158
94	ERA_21632823_ChIP-Seq_H3396_Human	0.88066482
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87888011
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87741645
97	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86492013
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86154500
99	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.84196202
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.83798827

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.98566945
2	MP0002102_abnormal_ear_morphology	4.34685676
3	MP0002876_abnormal_thyroid_physiology	3.63102707
4	MP0002139_abnormal_hepatobiliary_system	3.60676286
5	MP0009697_abnormal_copulation	2.73548961
6	MP0008875_abnormal_xenobiotic_pharmacok	2.58107368
7	MP0005645_abnormal_hypothalamus_physiol	2.54876912
8	MP0003252_abnormal_bile_duct	2.50774725
9	MP0003195_calcinosis	2.47239756
10	MP0005360_urolithiasis	2.40618057
11	MP0002928_abnormal_bile_duct	2.39902814
12	MP0002234_abnormal_pharynx_morphology	2.35719779
13	MP0003806_abnormal_nucleotide_metabolis	2.35057129
14	MP0002822_catalepsy	2.25421849
15	MP0004885_abnormal_endolymph	2.04535941
16	MP0003787_abnormal_imprinting	2.04519243
17	MP0010386_abnormal_urinary_bladder	1.97368165
18	MP0006036_abnormal_mitochondrial_physio	1.94403327
19	MP0006292_abnormal_olfactory_placode	1.93314156
20	MP0005408_hypopigmentation	1.85571106
21	MP0002163_abnormal_gland_morphology	1.82605200
22	MP0003283_abnormal_digestive_organ	1.76163845
23	MP0001984_abnormal_olfaction	1.74545788
24	MP0004145_abnormal_muscle_electrophysio	1.64940452
25	MP0001764_abnormal_homeostasis	1.63783671
26	MP0008789_abnormal_olfactory_epithelium	1.62178994
27	MP0005551_abnormal_eye_electrophysiolog	1.56701174
28	MP0003718_maternal_effect	1.55411546
29	MP0005365_abnormal_bile_salt	1.53739371
30	MP0000685_abnormal_immune_system	1.45321177
31	MP0006276_abnormal_autonomic_nervous	1.42965440
32	MP0002272_abnormal_nervous_system	1.41103417
33	MP0002837_dystrophic_cardiac_calcinosis	1.40202499
34	MP0003646_muscle_fatigue	1.31896622
35	MP0003121_genomic_imprinting	1.31023350
36	MP0003868_abnormal_feces_composition	1.30295131
37	MP0003186_abnormal_redox_activity	1.28925040
38	MP0006035_abnormal_mitochondrial_morpho	1.28889408
39	MP0004142_abnormal_muscle_tone	1.26011914
40	MP0008995_early_reproductive_senescence	1.24593295
41	MP0003122_maternal_imprinting	1.21377690
42	MP0000631_abnormal_neuroendocrine_gland	1.21168110
43	MP0005410_abnormal_fertilization	1.19842215
44	MP0005332_abnormal_amino_acid	1.14871571
45	MP0000049_abnormal_middle_ear	1.14710049
46	MP0005636_abnormal_mineral_homeostasis	1.14609118
47	MP0002160_abnormal_reproductive_system	1.12399845
48	MP0005084_abnormal_gallbladder_morpholo	1.10695925
49	MP0008872_abnormal_physiological_respon	1.08179670
50	MP0001529_abnormal_vocalization	1.05141776
51	MP0009046_muscle_twitch	1.04567553
52	MP0008058_abnormal_DNA_repair	1.03018037
53	MP0002653_abnormal_ependyma_morphology	0.99743213
54	MP0005499_abnormal_olfactory_system	0.99396051
55	MP0005394_taste/olfaction_phenotype	0.99396051
56	MP0009745_abnormal_behavioral_response	0.98079552
57	MP0001661_extended_life_span	0.97761833
58	MP0005647_abnormal_sex_gland	0.97749146
59	MP0003693_abnormal_embryo_hatching	0.96991010
60	MP0005253_abnormal_eye_physiology	0.95579431
61	MP0003183_abnormal_peptide_metabolism	0.93748115
62	MP0008877_abnormal_DNA_methylation	0.90643221
63	MP0005387_immune_system_phenotype	0.89923625
64	MP0001790_abnormal_immune_system	0.89923625
65	MP0005389_reproductive_system_phenotype	0.89500122
66	MP0005377_hearing/vestibular/ear_phenot	0.89366000
67	MP0003878_abnormal_ear_physiology	0.89366000
68	MP0004133_heterotaxia	0.89254127
69	MP0003329_amyloid_beta_deposits	0.87494902
70	MP0000604_amyloidosis	0.87451944
71	MP0004742_abnormal_vestibular_system	0.85754247
72	MP0005085_abnormal_gallbladder_physiolo	0.85559415
73	MP0002210_abnormal_sex_determination	0.84895594
74	MP0010094_abnormal_chromosome_stability	0.84674827
75	MP0003011_delayed_dark_adaptation	0.84281953
76	MP0001986_abnormal_taste_sensitivity	0.82834449
77	MP0003698_abnormal_male_reproductive	0.82564123
78	MP0001119_abnormal_female_reproductive	0.81246486
79	MP0001968_abnormal_touch/_nociception	0.80491498
80	MP0000653_abnormal_sex_gland	0.79096572
81	MP0005379_endocrine/exocrine_gland_phen	0.78636960
82	MP0001501_abnormal_sleep_pattern	0.76351113
83	MP0005646_abnormal_pituitary_gland	0.76149513
84	MP0000613_abnormal_salivary_gland	0.74555340
85	MP0008007_abnormal_cellular_replicative	0.73538944
86	MP0006072_abnormal_retinal_apoptosis	0.72751358
87	MP0003137_abnormal_impulse_conducting	0.72609366
88	MP0002277_abnormal_respiratory_mucosa	0.72239657
89	MP0005395_other_phenotype	0.71230359
90	MP0001929_abnormal_gametogenesis	0.70904844
91	MP0002557_abnormal_social/conspecific_i	0.69486376
92	MP0002064_seizures	0.68530133
93	MP0005195_abnormal_posterior_eye	0.68481097
94	MP0002736_abnormal_nociception_after	0.68182797
95	MP0009379_abnormal_foot_pigmentation	0.67642484
96	MP0001145_abnormal_male_reproductive	0.65987348
97	MP0001970_abnormal_pain_threshold	0.65823485
98	MP0005319_abnormal_enzyme/_coenzyme	0.65583659
99	MP0001835_abnormal_antigen_presentation	0.62165015
100	MP0010329_abnormal_lipoprotein_level	0.57974715

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bile duct proliferation (HP:0001408)	4.78657187
2	Abnormal biliary tract physiology (HP:0012439)	4.78657187
3	Molar tooth sign on MRI (HP:0002419)	4.61505028
4	Abnormality of midbrain morphology (HP:0002418)	4.61505028
5	Stomatitis (HP:0010280)	4.22553321
6	Type II lissencephaly (HP:0007260)	3.82773092
7	Pancreatic cysts (HP:0001737)	3.61765033
8	Supernumerary spleens (HP:0009799)	3.60227178
9	Pancreatic fibrosis (HP:0100732)	3.39621293
10	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.35536901
11	Abnormality of the labia minora (HP:0012880)	3.35188978
12	Asplenia (HP:0001746)	3.24846403
13	Acute necrotizing encephalopathy (HP:0006965)	3.22810152
14	Nephronophthisis (HP:0000090)	3.08679074
15	Increased CSF lactate (HP:0002490)	3.05434802
16	Abnormality of the renal medulla (HP:0100957)	3.04264351
17	Adrenal hypoplasia (HP:0000835)	2.98109620
18	Acute encephalopathy (HP:0006846)	2.97071090
19	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.97038069
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94912370
21	Mitochondrial inheritance (HP:0001427)	2.90546326
22	Cystic liver disease (HP:0006706)	2.89013060
23	Hypoplastic pelvis (HP:0008839)	2.83971600
24	Congenital stationary night blindness (HP:0007642)	2.81533852
25	Abnormality of the renal cortex (HP:0011035)	2.80121155
26	True hermaphroditism (HP:0010459)	2.79041839
27	Abnormal drinking behavior (HP:0030082)	2.72617993
28	Polydipsia (HP:0001959)	2.72617993
29	Progressive macrocephaly (HP:0004481)	2.68778559
30	Increased IgM level (HP:0003496)	2.67845626
31	Abolished electroretinogram (ERG) (HP:0000550)	2.56793122
32	Absent thumb (HP:0009777)	2.56235689
33	Elevated erythrocyte sedimentation rate (HP:0003565)	2.49970861
34	Hyperglycinuria (HP:0003108)	2.48010599
35	Lissencephaly (HP:0001339)	2.46119100
36	Hepatic necrosis (HP:0002605)	2.45664425
37	Hepatocellular necrosis (HP:0001404)	2.42330836
38	Thyroid-stimulating hormone excess (HP:0002925)	2.40855180
39	Oligodactyly (HP:0012165)	2.39732960
40	Renal Fanconi syndrome (HP:0001994)	2.36311553
41	Cerebellar dysplasia (HP:0007033)	2.28511902
42	Impulsivity (HP:0100710)	2.28216205
43	Polyphagia (HP:0002591)	2.24518726
44	Optic disc pallor (HP:0000543)	2.22446579
45	Cerebral edema (HP:0002181)	2.22405763
46	Polyuria (HP:0000103)	2.21407878
47	Oligodactyly (hands) (HP:0001180)	2.17520493
48	Pigmentary retinal degeneration (HP:0001146)	2.16436554
49	Hyperglycinemia (HP:0002154)	2.14919093
50	Increased serum lactate (HP:0002151)	2.13808473
51	Spastic paraparesis (HP:0002313)	2.12538414
52	Flat capital femoral epiphysis (HP:0003370)	2.08874282
53	Abnormality of alanine metabolism (HP:0010916)	2.04107918
54	Hyperalaninemia (HP:0003348)	2.04107918
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04107918
56	Medial flaring of the eyebrow (HP:0010747)	2.04037922
57	Growth hormone deficiency (HP:0000824)	2.03052766
58	Enlarged kidneys (HP:0000105)	2.01783979
59	Potter facies (HP:0002009)	2.01299410
60	Facial shape deformation (HP:0011334)	2.01299410
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99987797
62	Tinnitus (HP:0000360)	1.98020301
63	Congenital hepatic fibrosis (HP:0002612)	1.96684746
64	Cleft eyelid (HP:0000625)	1.93441910
65	Abnormal urine output (HP:0012590)	1.91368353
66	Reticulocytopenia (HP:0001896)	1.89877613
67	Pancytopenia (HP:0001876)	1.89685613
68	Glycosuria (HP:0003076)	1.89657597
69	Abnormality of urine glucose concentration (HP:0011016)	1.89657597
70	Retinal dysplasia (HP:0007973)	1.89622666
71	Spontaneous abortion (HP:0005268)	1.89110652
72	Colon cancer (HP:0003003)	1.86760058
73	Leukodystrophy (HP:0002415)	1.84286223
74	Facial hemangioma (HP:0000329)	1.83682624
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82577707
76	Abnormality of glycine metabolism (HP:0010895)	1.82577707
77	Hypokalemic alkalosis (HP:0001949)	1.80126588
78	Portal hypertension (HP:0001409)	1.80116151
79	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.79732040
80	Poor suck (HP:0002033)	1.74069213
81	Renal cortical cysts (HP:0000803)	1.72481958
82	Increased serum pyruvate (HP:0003542)	1.72443499
83	Tubulointerstitial fibrosis (HP:0005576)	1.72038532
84	IgG deficiency (HP:0004315)	1.71332781
85	Lactic acidosis (HP:0003128)	1.71212942
86	Abnormality of renal excretion (HP:0011036)	1.70171569
87	Dandy-Walker malformation (HP:0001305)	1.70094417
88	Lipid accumulation in hepatocytes (HP:0006561)	1.67507331
89	Abnormality of glycolysis (HP:0004366)	1.66783470
90	Poor head control (HP:0002421)	1.65871792
91	Abnormality of the hepatic vasculature (HP:0006707)	1.64997430
92	Disproportionate short-trunk short stature (HP:0003521)	1.64916467
93	Neutropenia (HP:0001875)	1.64632105
94	Increased hepatocellular lipid droplets (HP:0006565)	1.64631568
95	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.63778411
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.63402807
97	Inability to walk (HP:0002540)	1.63191196
98	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.62128450
99	Abnormal pupillary function (HP:0007686)	1.61980498
100	Narrow forehead (HP:0000341)	1.60812088

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.06087118
2	BCKDK	3.36350290
3	INSRR	2.71625836
4	DYRK2	2.39503387
5	WNK4	2.36064434
6	ADRBK2	2.24304733
7	NUAK1	2.23441365
8	CCNB1	2.13258244
9	CDK8	2.13189017
10	CDC7	2.12449908
11	STK39	2.00897462
12	FRK	1.99469237
13	VRK2	1.91733095
14	LMTK2	1.90286723
15	TAF1	1.87961192
16	GRK1	1.80928242
17	WNK3	1.66639913
18	OXSR1	1.64374732
19	PINK1	1.64277129
20	RPS6KA4	1.63218551
21	DAPK2	1.62754927
22	EIF2AK1	1.57690567
23	TRIM28	1.57574354
24	DAPK1	1.57216003
25	CSNK1A1L	1.48168289
26	MAP3K13	1.44847104
27	BMPR1B	1.42235579
28	MAP3K7	1.40542564
29	CSNK1G3	1.37346888
30	PIM2	1.31084269
31	CDK19	1.30878495
32	TAOK3	1.29100782
33	MST4	1.26876490
34	PIK3CG	1.26718579
35	TXK	1.24383343
36	EIF2AK3	1.21748826
37	CSNK1G2	1.15724771
38	PAK3	1.15078249
39	PAK6	1.14433925
40	WEE1	1.14035586
41	CSNK1G1	1.08578067
42	PLK4	1.08505193
43	VRK1	1.06575218
44	BCR	1.05063789
45	TGFBR1	1.01985462
46	NME1	0.99613855
47	TIE1	0.98700622
48	PLK2	0.94970524
49	EPHA3	0.88957919
50	DAPK3	0.87211318
51	MAPK13	0.87111072
52	CASK	0.86344791
53	IKBKB	0.84206252
54	CAMK2B	0.81784820
55	TLK1	0.78413307
56	CDK7	0.76713794
57	NTRK2	0.74418709
58	EIF2AK2	0.74236954
59	TNIK	0.74123145
60	SYK	0.71807231
61	PLK3	0.70021199
62	NME2	0.67932603
63	EPHB2	0.66524940
64	STK16	0.64347440
65	TSSK6	0.64128629
66	DYRK1B	0.63035257
67	TEC	0.62772664
68	PASK	0.61757105
69	NEK1	0.56237456
70	ADRBK1	0.56041829
71	ERBB2	0.56010002
72	CAMK2D	0.55258845
73	LRRK2	0.54520827
74	ATR	0.54332992
75	PKN1	0.53077653
76	PDK2	0.51806808
77	PIK3CA	0.51134867
78	CSNK2A2	0.50493664
79	TYRO3	0.49847306
80	PRKD2	0.49622007
81	CAMK4	0.49427687
82	PRKCQ	0.49287106
83	ATM	0.48999944
84	RPS6KA5	0.48139786
85	KIT	0.47172961
86	CSNK2A1	0.47077693
87	PRKCE	0.46091924
88	LYN	0.45345643
89	MAP3K12	0.44331718
90	PRKACA	0.43622619
91	PRKCI	0.43592378
92	PRKCH	0.40663729
93	GRK5	0.40171361
94	PRKCG	0.39705571
95	BTK	0.39513707
96	AURKB	0.39104061
97	OBSCN	0.38906089
98	PRKACG	0.34806408
99	LATS1	0.34483130
100	CSNK1A1	0.33771081

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.66055045
2	Protein export_Homo sapiens_hsa03060	2.54705023
3	Ribosome_Homo sapiens_hsa03010	2.44284678
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36100094
5	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.30397812
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.16632325
7	Chemical carcinogenesis_Homo sapiens_hsa05204	2.10062148
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.00132799
9	One carbon pool by folate_Homo sapiens_hsa00670	1.96828704
10	RNA polymerase_Homo sapiens_hsa03020	1.96022882
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.95751464
12	RNA degradation_Homo sapiens_hsa03018	1.90973184
13	Folate biosynthesis_Homo sapiens_hsa00790	1.90582011
14	Parkinsons disease_Homo sapiens_hsa05012	1.90456127
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.86988997
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.86770230
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85956382
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.85771215
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81292836
20	Peroxisome_Homo sapiens_hsa04146	1.80716805
21	Proteasome_Homo sapiens_hsa03050	1.80346133
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.79995846
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.73600750
24	Mismatch repair_Homo sapiens_hsa03430	1.73589659
25	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.70201573
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.67227621
27	Propanoate metabolism_Homo sapiens_hsa00640	1.66658854
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61783714
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61266611
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52764824
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.51109809
32	Homologous recombination_Homo sapiens_hsa03440	1.47251055
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45661565
34	Retinol metabolism_Homo sapiens_hsa00830	1.42016346
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.41914202
36	DNA replication_Homo sapiens_hsa03030	1.33687461
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.33161009
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.31857043
39	Asthma_Homo sapiens_hsa05310	1.26857598
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24638007
41	Sulfur relay system_Homo sapiens_hsa04122	1.23881112
42	Huntingtons disease_Homo sapiens_hsa05016	1.22720837
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22350527
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17537274
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16093505
46	Primary immunodeficiency_Homo sapiens_hsa05340	1.15587781
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10982846
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.10441149
49	Alzheimers disease_Homo sapiens_hsa05010	1.10260633
50	Phenylalanine metabolism_Homo sapiens_hsa00360	1.08589221
51	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08347757
52	Fatty acid elongation_Homo sapiens_hsa00062	1.07033782
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06137783
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04098938
55	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.01353829
56	Allograft rejection_Homo sapiens_hsa05330	0.99404684
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97781499
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.97289653
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.96929081
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.94730581
61	Phototransduction_Homo sapiens_hsa04744	0.94021172
62	Nicotine addiction_Homo sapiens_hsa05033	0.91535170
63	Caffeine metabolism_Homo sapiens_hsa00232	0.90131091
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.87373273
65	Glutathione metabolism_Homo sapiens_hsa00480	0.86419645
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.86391885
67	Metabolic pathways_Homo sapiens_hsa01100	0.82479792
68	Butanoate metabolism_Homo sapiens_hsa00650	0.81922015
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80502856
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79967910
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.78132565
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.74902452
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.74220798
74	Purine metabolism_Homo sapiens_hsa00230	0.73400301
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72655078
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69241897
77	Carbon metabolism_Homo sapiens_hsa01200	0.68403263
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65708106
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.64909983
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62719426
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.62271365
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60655388
83	Fatty acid degradation_Homo sapiens_hsa00071	0.59872225
84	Complement and coagulation cascades_Homo sapiens_hsa04610	0.52646539
85	RNA transport_Homo sapiens_hsa03013	0.50622503
86	Basal transcription factors_Homo sapiens_hsa03022	0.49623788
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46884431
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46474458
89	Sulfur metabolism_Homo sapiens_hsa00920	0.46385085
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46258398
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.45084134
92	Bile secretion_Homo sapiens_hsa04976	0.41181805
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40244858
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39606857
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34737450
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34608910
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34254391
98	Spliceosome_Homo sapiens_hsa03040	0.32209356
99	Histidine metabolism_Homo sapiens_hsa00340	0.32034499
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32002197

RPL7P53

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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