RPL7P54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)5.54886824
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.54886824
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.52486578
4ATP synthesis coupled proton transport (GO:0015986)5.52486578
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.46425871
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.34420630
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.28849030
8viral transcription (GO:0019083)5.04003896
9translational termination (GO:0006415)4.86031521
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.60700735
11cotranslational protein targeting to membrane (GO:0006613)4.58602116
12protein targeting to ER (GO:0045047)4.52088366
13ribosomal large subunit biogenesis (GO:0042273)4.50317278
14protein localization to endoplasmic reticulum (GO:0070972)4.34690235
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.32692044
16ribosomal small subunit assembly (GO:0000028)4.26602628
17behavioral response to nicotine (GO:0035095)4.20778973
18translational elongation (GO:0006414)4.11204314
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.99488747
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.99488747
21ribosomal small subunit biogenesis (GO:0042274)3.99295476
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99037898
23regulation of microtubule-based movement (GO:0060632)3.95599079
24aldehyde catabolic process (GO:0046185)3.95027226
25signal peptide processing (GO:0006465)3.92099062
26dentate gyrus development (GO:0021542)3.90782719
27maturation of SSU-rRNA (GO:0030490)3.86204790
28positive regulation of interleukin-17 production (GO:0032740)3.83362637
29regulation of cilium movement (GO:0003352)3.82439363
30negative regulation of T cell differentiation in thymus (GO:0033085)3.79226904
31nonmotile primary cilium assembly (GO:0035058)3.76082553
32water-soluble vitamin biosynthetic process (GO:0042364)3.75066377
33regulation of isotype switching to IgG isotypes (GO:0048302)3.72104834
34dopaminergic neuron differentiation (GO:0071542)3.65471420
35viral life cycle (GO:0019058)3.62620026
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62228359
37cell wall macromolecule catabolic process (GO:0016998)3.55441547
38cellular protein complex disassembly (GO:0043624)3.51105057
39negative regulation of B cell apoptotic process (GO:0002903)3.45424353
40indolalkylamine metabolic process (GO:0006586)3.41469508
41piRNA metabolic process (GO:0034587)3.37449650
42respiratory electron transport chain (GO:0022904)3.35534748
43electron transport chain (GO:0022900)3.34530160
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31669476
45regulation of dopamine metabolic process (GO:0042053)3.31640904
46regulation of catecholamine metabolic process (GO:0042069)3.31640904
47translational initiation (GO:0006413)3.30708136
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.29658542
49protein neddylation (GO:0045116)3.29181284
50kidney morphogenesis (GO:0060993)3.28942927
51chaperone-mediated protein transport (GO:0072321)3.28328463
52DNA damage response, detection of DNA damage (GO:0042769)3.26793999
53regulation of cellular respiration (GO:0043457)3.25134509
54protein targeting to membrane (GO:0006612)3.22181603
55positive regulation of activated T cell proliferation (GO:0042104)3.19772811
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19516123
57pattern specification involved in kidney development (GO:0061004)3.15710137
58translation (GO:0006412)3.15670733
59termination of RNA polymerase III transcription (GO:0006386)3.13835637
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.13835637
61regulation of non-canonical Wnt signaling pathway (GO:2000050)3.12464704
62somite development (GO:0061053)3.10845979
63regulation of immunoglobulin secretion (GO:0051023)3.09328859
64DNA deamination (GO:0045006)3.08299564
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02208608
66cell wall macromolecule metabolic process (GO:0044036)3.00884877
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99439553
68tryptophan metabolic process (GO:0006568)2.91793632
69negative regulation of macrophage differentiation (GO:0045650)2.90783407
70regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.90247458
71regulation of podosome assembly (GO:0071801)2.89553044
72segment specification (GO:0007379)2.89095097
73protein complex disassembly (GO:0043241)2.88285184
74ubiquinone biosynthetic process (GO:0006744)2.84031420
75ATP biosynthetic process (GO:0006754)2.82833468
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82007918
77negative regulation of appetite (GO:0032099)2.79767934
78negative regulation of response to food (GO:0032096)2.79767934
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76233856
80macromolecular complex disassembly (GO:0032984)2.74779247
81detection of light stimulus involved in sensory perception (GO:0050962)2.74084641
82detection of light stimulus involved in visual perception (GO:0050908)2.74084641
83amine catabolic process (GO:0009310)2.72491727
84cellular biogenic amine catabolic process (GO:0042402)2.72491727
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72310080
86response to insecticide (GO:0017085)2.71873575
87positive regulation of growth hormone secretion (GO:0060124)2.71057136
88photoreceptor cell maintenance (GO:0045494)2.70007909
89tryptophan catabolic process (GO:0006569)2.68951231
90indole-containing compound catabolic process (GO:0042436)2.68951231
91indolalkylamine catabolic process (GO:0046218)2.68951231
92neuron fate determination (GO:0048664)2.67499398
93ganglion development (GO:0061548)2.67002623
94ubiquinone metabolic process (GO:0006743)2.63387238
95dopamine transport (GO:0015872)2.59582754
96left/right axis specification (GO:0070986)2.58603436
97kynurenine metabolic process (GO:0070189)2.57929305
98regulation of oxidative phosphorylation (GO:0002082)2.57017614
99deoxyribose phosphate catabolic process (GO:0046386)2.55841119
100synaptic transmission, cholinergic (GO:0007271)2.55797097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.13152131
2EZH2_22144423_ChIP-Seq_EOC_Human4.74018535
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.66563877
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.62334582
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30496156
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.09766864
7ZNF274_21170338_ChIP-Seq_K562_Hela2.93680046
8VDR_22108803_ChIP-Seq_LS180_Human2.58916471
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.50792925
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47159685
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40143446
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.34142530
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22646574
14EWS_26573619_Chip-Seq_HEK293_Human1.96691545
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89348470
16GBX2_23144817_ChIP-Seq_PC3_Human1.88693028
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86680904
18ETV2_25802403_ChIP-Seq_MESCs_Mouse1.82390043
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67032060
20FUS_26573619_Chip-Seq_HEK293_Human1.65117278
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61937246
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57733714
23P300_19829295_ChIP-Seq_ESCs_Human1.56622668
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52417997
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.51502238
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51465485
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51308144
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.48725993
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.48170324
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44864117
31VDR_23849224_ChIP-Seq_CD4+_Human1.41260784
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40924819
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40014745
34FOXP3_21729870_ChIP-Seq_TREG_Human1.39239930
35TAF15_26573619_Chip-Seq_HEK293_Human1.39173591
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39144206
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39131611
38TP53_22573176_ChIP-Seq_HFKS_Human1.38263852
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36818649
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33946971
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33781025
42REST_21632747_ChIP-Seq_MESCs_Mouse1.31917281
43ELK1_19687146_ChIP-ChIP_HELA_Human1.31834439
44MYC_18940864_ChIP-ChIP_HL60_Human1.31025505
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29697270
46RNF2_27304074_Chip-Seq_NSC_Mouse1.29178033
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.29122645
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24202595
49FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23393162
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21888931
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.21888931
52NANOG_19829295_ChIP-Seq_ESCs_Human1.20156171
53SOX2_19829295_ChIP-Seq_ESCs_Human1.20156171
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19332589
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18096332
56IRF1_19129219_ChIP-ChIP_H3396_Human1.17185544
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.17047847
58ERA_21632823_ChIP-Seq_H3396_Human1.15957717
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14385518
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14131185
61AR_20517297_ChIP-Seq_VCAP_Human1.13437633
62TTF2_22483619_ChIP-Seq_HELA_Human1.13417258
63BCAT_22108803_ChIP-Seq_LS180_Human1.13147256
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.13046344
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.12609727
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09410723
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08032904
68NANOG_20526341_ChIP-Seq_ESCs_Human1.07953535
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.07883340
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06703004
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06455326
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05488596
73CBP_20019798_ChIP-Seq_JUKART_Human1.03827659
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03827659
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03337838
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03109099
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00688725
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.00220055
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00210463
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99380047
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98302186
82TCF4_22108803_ChIP-Seq_LS180_Human0.97789971
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97541837
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.97498517
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96980078
86NCOR_22424771_ChIP-Seq_293T_Human0.95759482
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95418892
88ER_23166858_ChIP-Seq_MCF-7_Human0.94197673
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93049726
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.90893140
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89718972
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.89519342
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89496952
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88539168
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88539168
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87777251
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.87645485
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.87403990
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.87327770
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86391012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.17917744
2MP0009379_abnormal_foot_pigmentation3.68761859
3MP0000566_synostosis3.02128576
4MP0008789_abnormal_olfactory_epithelium2.92637456
5MP0008004_abnormal_stomach_pH2.67523240
6MP0002938_white_spotting2.66420119
7MP0006292_abnormal_olfactory_placode2.64070683
8MP0004145_abnormal_muscle_electrophysio2.46562207
9MP0005394_taste/olfaction_phenotype2.38440236
10MP0005499_abnormal_olfactory_system2.38440236
11MP0002102_abnormal_ear_morphology2.24304493
12MP0003880_abnormal_central_pattern2.15804346
13MP0001835_abnormal_antigen_presentation2.14725196
14MP0001968_abnormal_touch/_nociception2.13655643
15MP0004885_abnormal_endolymph2.11844398
16MP0005377_hearing/vestibular/ear_phenot2.11000322
17MP0003878_abnormal_ear_physiology2.11000322
18MP0000372_irregular_coat_pigmentation2.04548180
19MP0001905_abnormal_dopamine_level2.04358732
20MP0001984_abnormal_olfaction1.92582883
21MP0003646_muscle_fatigue1.90520436
22MP0003186_abnormal_redox_activity1.79781889
23MP0002234_abnormal_pharynx_morphology1.79623190
24MP0000569_abnormal_digit_pigmentation1.78107276
25MP0002736_abnormal_nociception_after1.76771969
26MP0001348_abnormal_lacrimal_gland1.76247248
27MP0008872_abnormal_physiological_respon1.70798902
28MP0008877_abnormal_DNA_methylation1.67352740
29MP0002163_abnormal_gland_morphology1.59659001
30MP0010030_abnormal_orbit_morphology1.58614972
31MP0008875_abnormal_xenobiotic_pharmacok1.58142533
32MP0003718_maternal_effect1.58039945
33MP0001529_abnormal_vocalization1.57852814
34MP0005645_abnormal_hypothalamus_physiol1.55633637
35MP0005174_abnormal_tail_pigmentation1.54797735
36MP0002095_abnormal_skin_pigmentation1.54162032
37MP0009745_abnormal_behavioral_response1.51901557
38MP0003121_genomic_imprinting1.46453587
39MP0002272_abnormal_nervous_system1.41392104
40MP0002184_abnormal_innervation1.40206467
41MP0003011_delayed_dark_adaptation1.34913082
42MP0002138_abnormal_hepatobiliary_system1.34878068
43MP0005379_endocrine/exocrine_gland_phen1.33550451
44MP0002233_abnormal_nose_morphology1.31991909
45MP0003122_maternal_imprinting1.29517963
46MP0004142_abnormal_muscle_tone1.29082660
47MP0000015_abnormal_ear_pigmentation1.27264701
48MP0005551_abnormal_eye_electrophysiolog1.25865432
49MP0004742_abnormal_vestibular_system1.25834812
50MP0005646_abnormal_pituitary_gland1.23396067
51MP0009046_muscle_twitch1.23004371
52MP0006036_abnormal_mitochondrial_physio1.21135886
53MP0006276_abnormal_autonomic_nervous1.20261129
54MP0002572_abnormal_emotion/affect_behav1.18994065
55MP0002557_abnormal_social/conspecific_i1.18055273
56MP0001293_anophthalmia1.16630738
57MP0001485_abnormal_pinna_reflex1.16542053
58MP0001440_abnormal_grooming_behavior1.14212152
59MP0005423_abnormal_somatic_nervous1.13194751
60MP0005075_abnormal_melanosome_morpholog1.11279722
61MP0006072_abnormal_retinal_apoptosis1.11181223
62MP0003195_calcinosis1.09450690
63MP0001970_abnormal_pain_threshold1.06774484
64MP0001986_abnormal_taste_sensitivity1.05235799
65MP0001502_abnormal_circadian_rhythm1.04311459
66MP0000778_abnormal_nervous_system1.02464562
67MP0002837_dystrophic_cardiac_calcinosis1.02283337
68MP0003300_gastrointestinal_ulcer1.02015403
69MP0000026_abnormal_inner_ear0.98649324
70MP0003638_abnormal_response/metabolism_0.98608295
71MP0003879_abnormal_hair_cell0.94093091
72MP0002067_abnormal_sensory_capabilities0.93791833
73MP0002752_abnormal_somatic_nervous0.92776699
74MP0010386_abnormal_urinary_bladder0.92703331
75MP0005195_abnormal_posterior_eye0.92187606
76MP0002160_abnormal_reproductive_system0.91765494
77MP0004147_increased_porphyrin_level0.89967102
78MP0003119_abnormal_digestive_system0.86947669
79MP0005253_abnormal_eye_physiology0.86551627
80MP0002733_abnormal_thermal_nociception0.86417265
81MP0002063_abnormal_learning/memory/cond0.81922989
82MP0003724_increased_susceptibility_to0.81410998
83MP0003635_abnormal_synaptic_transmissio0.79567076
84MP0008058_abnormal_DNA_repair0.79427794
85MP0009278_abnormal_bone_marrow0.78131471
86MP0001486_abnormal_startle_reflex0.77106562
87MP0000631_abnormal_neuroendocrine_gland0.76337693
88MP0005360_urolithiasis0.75083217
89MP0005084_abnormal_gallbladder_morpholo0.72024859
90MP0005167_abnormal_blood-brain_barrier0.71981638
91MP0003938_abnormal_ear_development0.71871635
92MP0003866_abnormal_defecation0.71350624
93MP0005389_reproductive_system_phenotype0.70525539
94MP0000049_abnormal_middle_ear0.67038804
95MP0009764_decreased_sensitivity_to0.65203370
96MP0001963_abnormal_hearing_physiology0.65048191
97MP0000604_amyloidosis0.64739212
98MP0005636_abnormal_mineral_homeostasis0.63644754
99MP0002148_abnormal_hypersensitivity_rea0.63549668
100MP0002822_catalepsy0.63460435

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.99386057
2Pancreatic fibrosis (HP:0100732)3.84475226
3Molar tooth sign on MRI (HP:0002419)3.64998357
4Abnormality of midbrain morphology (HP:0002418)3.64998357
5Pancreatic cysts (HP:0001737)3.59966141
6Abnormal mitochondria in muscle tissue (HP:0008316)3.51094410
7Abnormality of alanine metabolism (HP:0010916)3.38406449
8Hyperalaninemia (HP:0003348)3.38406449
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.38406449
10Reticulocytopenia (HP:0001896)3.33438870
11Progressive macrocephaly (HP:0004481)3.31940957
12Stenosis of the external auditory canal (HP:0000402)3.25909002
13Nephronophthisis (HP:0000090)3.21012900
14Acute encephalopathy (HP:0006846)3.18932831
15Mitochondrial inheritance (HP:0001427)3.17981234
16Hepatocellular necrosis (HP:0001404)3.16061408
17Hepatic necrosis (HP:0002605)3.08696716
18Abnormality of the renal cortex (HP:0011035)3.04646249
19Abnormal biliary tract physiology (HP:0012439)3.03370481
20Bile duct proliferation (HP:0001408)3.03370481
21Supernumerary spleens (HP:0009799)2.98790491
22Abnormality of the renal medulla (HP:0100957)2.94565516
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87479386
24Medial flaring of the eyebrow (HP:0010747)2.75445144
25Increased CSF lactate (HP:0002490)2.74965850
26Pendular nystagmus (HP:0012043)2.72454160
27Polydipsia (HP:0001959)2.70417590
28Abnormal drinking behavior (HP:0030082)2.70417590
29Abnormality of cells of the erythroid lineage (HP:0012130)2.69588964
30Type II lissencephaly (HP:0007260)2.62752535
31Anophthalmia (HP:0000528)2.62004223
323-Methylglutaconic aciduria (HP:0003535)2.58826583
33Macrocytic anemia (HP:0001972)2.58458448
34Gait imbalance (HP:0002141)2.57345192
35Rib fusion (HP:0000902)2.56128056
36Tubular atrophy (HP:0000092)2.53943058
37Colon cancer (HP:0003003)2.52136773
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.51745523
39Cystic liver disease (HP:0006706)2.49946115
40Asplenia (HP:0001746)2.47459252
41Thrombocytosis (HP:0001894)2.45534482
42Intestinal atresia (HP:0011100)2.44483846
43Cerebral edema (HP:0002181)2.44126684
44Median cleft lip (HP:0000161)2.43104806
45Methylmalonic acidemia (HP:0002912)2.37506333
46Enlarged kidneys (HP:0000105)2.36593222
47Elevated erythrocyte sedimentation rate (HP:0003565)2.35206043
48Abnormal ciliary motility (HP:0012262)2.34789609
49Progressive cerebellar ataxia (HP:0002073)2.32647456
50Oligodactyly (hands) (HP:0001180)2.30967791
51Optic disc pallor (HP:0000543)2.26078279
52Hypoplastic pelvis (HP:0008839)2.25386352
53Congenital stationary night blindness (HP:0007642)2.22918165
54True hermaphroditism (HP:0010459)2.19364251
55Polyphagia (HP:0002591)2.18823361
56Hyperglycinemia (HP:0002154)2.18769825
57Pallor (HP:0000980)2.16151014
58Polyuria (HP:0000103)2.15461515
59Lactic acidosis (HP:0003128)2.14672292
60Increased serum lactate (HP:0002151)2.11523502
61Abnormal rod and cone electroretinograms (HP:0008323)2.08918202
62Congenital hepatic fibrosis (HP:0002612)2.06271263
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02714734
64Congenital, generalized hypertrichosis (HP:0004540)1.98476325
65Abnormal respiratory motile cilium physiology (HP:0012261)1.98438437
66Abolished electroretinogram (ERG) (HP:0000550)1.96687392
67Renal cortical cysts (HP:0000803)1.95889707
68Hypoproteinemia (HP:0003075)1.94794356
69Large for gestational age (HP:0001520)1.94253229
70Hyperventilation (HP:0002883)1.93328320
71Leukodystrophy (HP:0002415)1.91141752
72Small hand (HP:0200055)1.90843934
73Hypomagnesemia (HP:0002917)1.89316369
74Hypoplasia of the ulna (HP:0003022)1.86722822
75Tubulointerstitial fibrosis (HP:0005576)1.86266112
76Septo-optic dysplasia (HP:0100842)1.85492155
77Oligodactyly (HP:0012165)1.85307938
78Abnormal number of erythroid precursors (HP:0012131)1.84026504
79Aplasia/hypoplasia of the uterus (HP:0008684)1.83940277
80Hypoplasia of the uterus (HP:0000013)1.82761162
81Anencephaly (HP:0002323)1.82113324
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81738724
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81738724
84Abnormal hemoglobin (HP:0011902)1.81252466
85Limb dystonia (HP:0002451)1.81016558
86Glycosuria (HP:0003076)1.80163962
87Abnormality of urine glucose concentration (HP:0011016)1.80163962
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79014272
89Chronic bronchitis (HP:0004469)1.78604673
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77839011
91Sclerocornea (HP:0000647)1.76597325
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75145548
93Spontaneous abortion (HP:0005268)1.75062713
94Poor speech (HP:0002465)1.74720799
95Bifid tongue (HP:0010297)1.74576686
96Type 2 muscle fiber atrophy (HP:0003554)1.72443437
97Abnormality of magnesium homeostasis (HP:0004921)1.71816276
98Congenital primary aphakia (HP:0007707)1.71631852
99Lethargy (HP:0001254)1.71544358
100Increased hepatocellular lipid droplets (HP:0006565)1.71492994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.94973334
2CDK193.40820166
3ADRBK22.99897175
4STK162.98586713
5WNK32.89737228
6TLK12.80951693
7MAP4K22.75318200
8GRK12.66289923
9DYRK22.51271688
10MARK12.48638286
11BCKDK2.44489044
12PHKG22.41676093
13PHKG12.41676093
14TAOK32.36620508
15NUAK12.16293255
16FRK1.80454282
17WNK41.70400830
18OXSR11.68537253
19BMPR1B1.66811750
20NEK11.63112430
21RPS6KA41.61931114
22EPHB21.59908938
23MAPK131.59219177
24NTRK31.55871151
25TEC1.47851461
26ZAK1.37356535
27PINK11.35339341
28EIF2AK31.28138786
29MAP2K71.23127611
30NME11.13708445
31CASK1.06611409
32FES1.05618874
33DAPK21.05223800
34NTRK21.04181717
35MAP3K41.02988535
36EPHA40.94025619
37DAPK30.93668197
38ABL20.88347997
39VRK20.88338000
40MAP3K120.85404435
41STK390.85369016
42TGFBR10.83220578
43PIK3CA0.82891867
44MKNK20.77753042
45TRIM280.76753174
46KIT0.75254363
47INSRR0.74865357
48MKNK10.74517840
49PRKCG0.73963921
50PKN10.73708449
51WEE10.73252521
52CSNK1G30.72964108
53RPS6KA50.72553129
54BCR0.71198664
55ADRBK10.71155001
56BTK0.69017948
57ACVR1B0.68596697
58PDK20.67800112
59CSNK1G20.66016359
60BMPR20.63202955
61MAP3K130.62004485
62MYLK0.61012330
63IKBKB0.60905353
64CSNK1G10.59939401
65MST40.59632296
66ITK0.58306323
67GRK50.57906942
68MAP2K40.55489751
69EIF2AK20.55428108
70TAF10.51606007
71PRKCE0.49747950
72CHEK20.49293801
73DAPK10.49206401
74ILK0.48416319
75WNK10.48352349
76PASK0.45736742
77SYK0.45557225
78PTK2B0.45224828
79VRK10.44156704
80CSNK1A1L0.43976856
81PIM20.43603274
82MAP3K60.43541678
83PRKCI0.37813056
84PLK10.36863129
85CAMK2A0.36478829
86CSNK2A20.35937155
87DYRK30.35888830
88PIK3CG0.35772894
89CSNK2A10.35169243
90CSF1R0.34397415
91TXK0.33978694
92PRKCQ0.33943011
93MAPK120.33373473
94LYN0.32774721
95MAPK150.32763172
96OBSCN0.32540906
97LRRK20.31677628
98MAP3K100.31670325
99PRKCD0.31299137
100MAPKAPK50.29112109

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.31043720
2Asthma_Homo sapiens_hsa053104.15563709
3Protein export_Homo sapiens_hsa030603.89238851
4Oxidative phosphorylation_Homo sapiens_hsa001903.33394666
5Allograft rejection_Homo sapiens_hsa053303.23866432
6Autoimmune thyroid disease_Homo sapiens_hsa053203.06091262
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.93345379
8Parkinsons disease_Homo sapiens_hsa050122.86068632
9Graft-versus-host disease_Homo sapiens_hsa053322.46128670
10RNA polymerase_Homo sapiens_hsa030202.34256001
11Type I diabetes mellitus_Homo sapiens_hsa049402.27372843
12Proteasome_Homo sapiens_hsa030502.26023959
13Cardiac muscle contraction_Homo sapiens_hsa042601.90765034
14Alzheimers disease_Homo sapiens_hsa050101.80964420
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80960541
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69493934
17Huntingtons disease_Homo sapiens_hsa050161.69215586
18Linoleic acid metabolism_Homo sapiens_hsa005911.64218989
19One carbon pool by folate_Homo sapiens_hsa006701.61836449
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53603736
21Propanoate metabolism_Homo sapiens_hsa006401.52982793
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51827955
23Tryptophan metabolism_Homo sapiens_hsa003801.49032883
24Regulation of autophagy_Homo sapiens_hsa041401.48270483
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45844701
26Arachidonic acid metabolism_Homo sapiens_hsa005901.36653616
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30495776
28Nicotine addiction_Homo sapiens_hsa050331.29422003
29Rheumatoid arthritis_Homo sapiens_hsa053231.29215994
30Mismatch repair_Homo sapiens_hsa034301.28588716
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25593218
32Phototransduction_Homo sapiens_hsa047441.21234864
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16247204
34Homologous recombination_Homo sapiens_hsa034401.08940236
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06912398
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03774864
37Nitrogen metabolism_Homo sapiens_hsa009101.00649474
38Peroxisome_Homo sapiens_hsa041460.94471922
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93823839
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92394062
41Pyrimidine metabolism_Homo sapiens_hsa002400.91311943
42RNA degradation_Homo sapiens_hsa030180.90734017
43Morphine addiction_Homo sapiens_hsa050320.89832963
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.85643951
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83375469
46Fanconi anemia pathway_Homo sapiens_hsa034600.80960893
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77072397
48Olfactory transduction_Homo sapiens_hsa047400.74484930
49Nucleotide excision repair_Homo sapiens_hsa034200.73630975
50Ether lipid metabolism_Homo sapiens_hsa005650.71935242
51GABAergic synapse_Homo sapiens_hsa047270.68599011
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66077635
53Sulfur relay system_Homo sapiens_hsa041220.65957864
54Taste transduction_Homo sapiens_hsa047420.65463074
55Pyruvate metabolism_Homo sapiens_hsa006200.63809479
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63349476
57Fatty acid degradation_Homo sapiens_hsa000710.61896233
58Basal transcription factors_Homo sapiens_hsa030220.61193490
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61145432
60RNA transport_Homo sapiens_hsa030130.59722096
61Systemic lupus erythematosus_Homo sapiens_hsa053220.59122939
62Purine metabolism_Homo sapiens_hsa002300.58188841
63Staphylococcus aureus infection_Homo sapiens_hsa051500.57642230
64Caffeine metabolism_Homo sapiens_hsa002320.57407415
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54601282
66Chemical carcinogenesis_Homo sapiens_hsa052040.54396848
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53681580
68Steroid biosynthesis_Homo sapiens_hsa001000.52011352
69Leishmaniasis_Homo sapiens_hsa051400.51238220
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.50985429
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.50740444
72DNA replication_Homo sapiens_hsa030300.50675232
73Butanoate metabolism_Homo sapiens_hsa006500.49448697
74Retinol metabolism_Homo sapiens_hsa008300.49373283
75Metabolic pathways_Homo sapiens_hsa011000.47670048
76Serotonergic synapse_Homo sapiens_hsa047260.46349554
77Antigen processing and presentation_Homo sapiens_hsa046120.44967523
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44664688
79beta-Alanine metabolism_Homo sapiens_hsa004100.44232257
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43590783
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42109260
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42002537
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41530179
84Ovarian steroidogenesis_Homo sapiens_hsa049130.41529751
85Fat digestion and absorption_Homo sapiens_hsa049750.40732354
86Fatty acid elongation_Homo sapiens_hsa000620.36955080
87Hedgehog signaling pathway_Homo sapiens_hsa043400.35870314
88Hematopoietic cell lineage_Homo sapiens_hsa046400.34591021
89Spliceosome_Homo sapiens_hsa030400.33962512
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33505668
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33238351
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32529827
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.29667991
94Viral myocarditis_Homo sapiens_hsa054160.29546729
95T cell receptor signaling pathway_Homo sapiens_hsa046600.27369751
96Glutathione metabolism_Homo sapiens_hsa004800.24981769
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24895956
98Collecting duct acid secretion_Homo sapiens_hsa049660.24800233
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.24467464
100Arginine and proline metabolism_Homo sapiens_hsa003300.22777148

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