ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.05178452
2	maturation of SSU-rRNA (GO:0030490)	7.91176611
3	viral transcription (GO:0019083)	7.83322543
4	ribosomal small subunit biogenesis (GO:0042274)	7.67772861
5	translational termination (GO:0006415)	7.52394828
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.18021903
7	cotranslational protein targeting to membrane (GO:0006613)	6.05155947
8	translational elongation (GO:0006414)	6.02700155
9	protein targeting to ER (GO:0045047)	6.00134625
10	behavioral response to nicotine (GO:0035095)	5.83909919
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.77110705
12	viral life cycle (GO:0019058)	5.74041657
13	cellular protein complex disassembly (GO:0043624)	5.69074556
14	protein localization to endoplasmic reticulum (GO:0070972)	5.58185491
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.47565960
16	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.01818309
17	protein complex disassembly (GO:0043241)	4.83147792
18	macromolecular complex disassembly (GO:0032984)	4.51872415
19	auditory receptor cell differentiation (GO:0042491)	4.42934591
20	translational initiation (GO:0006413)	4.39671850
21	head development (GO:0060322)	4.36899321
22	pyrimidine nucleotide catabolic process (GO:0006244)	4.34288446
23	synaptic transmission, cholinergic (GO:0007271)	4.15173171
24	protein targeting to membrane (GO:0006612)	4.02949895
25	cell proliferation in forebrain (GO:0021846)	3.88592061
26	meiotic chromosome segregation (GO:0045132)	3.75966708
27	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.74467094
28	substrate-independent telencephalic tangential migration (GO:0021826)	3.74467094
29	negative regulation of cAMP-mediated signaling (GO:0043951)	3.66187763
30	protein neddylation (GO:0045116)	3.60112457
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.53857387
32	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.51806283
33	ribosomal large subunit biogenesis (GO:0042273)	3.51691408
34	nonmotile primary cilium assembly (GO:0035058)	3.44380855
35	neuron fate determination (GO:0048664)	3.43204556
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40937931
37	mRNA catabolic process (GO:0006402)	3.36052886
38	base-excision repair, AP site formation (GO:0006285)	3.35991437
39	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.35292665
40	intraciliary transport (GO:0042073)	3.34207722
41	peptidyl-threonine dephosphorylation (GO:0035970)	3.29163509
42	translation (GO:0006412)	3.20120654
43	positive regulation of action potential (GO:0045760)	3.18397896
44	ATP synthesis coupled proton transport (GO:0015986)	3.16418552
45	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.16418552
46	transmission of nerve impulse (GO:0019226)	3.11022686
47	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.10927155
48	regulation of cilium movement (GO:0003352)	3.10259278
49	tongue development (GO:0043586)	3.02716876
50	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.99777090
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.98931826
52	regulation of action potential (GO:0098900)	2.97941599
53	response to parathyroid hormone (GO:0071107)	2.97735520
54	nephron epithelium morphogenesis (GO:0072088)	2.95349384
55	nephron tubule morphogenesis (GO:0072078)	2.95349384
56	RNA catabolic process (GO:0006401)	2.95024278
57	viral protein processing (GO:0019082)	2.90949680
58	ncRNA 3-end processing (GO:0043628)	2.90504783
59	otic vesicle formation (GO:0030916)	2.89683733
60	dentate gyrus development (GO:0021542)	2.88455764
61	positive regulation of respiratory burst (GO:0060267)	2.87052030
62	phosphate ion transport (GO:0006817)	2.84330499
63	neuronal stem cell maintenance (GO:0097150)	2.84141216
64	opioid receptor signaling pathway (GO:0038003)	2.84005387
65	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.80880029
66	regulation of microtubule-based movement (GO:0060632)	2.79359168
67	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78472028
68	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.78472028
69	water-soluble vitamin biosynthetic process (GO:0042364)	2.76496153
70	cardiovascular system development (GO:0072358)	2.72853510
71	inner ear receptor cell differentiation (GO:0060113)	2.72519358
72	somite development (GO:0061053)	2.72371903
73	ribonucleoprotein complex biogenesis (GO:0022613)	2.71743724
74	urate metabolic process (GO:0046415)	2.70319005
75	regulation of hippo signaling (GO:0035330)	2.69079558
76	adaptation of signaling pathway (GO:0023058)	2.68170589
77	L-fucose catabolic process (GO:0042355)	2.67426711
78	fucose catabolic process (GO:0019317)	2.67426711
79	L-fucose metabolic process (GO:0042354)	2.67426711
80	cellular ketone body metabolic process (GO:0046950)	2.65569658
81	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.64738951
82	endoderm formation (GO:0001706)	2.63879162
83	establishment of protein localization to membrane (GO:0090150)	2.63118718
84	cell wall macromolecule catabolic process (GO:0016998)	2.62711401
85	axon ensheathment in central nervous system (GO:0032291)	2.61594531
86	central nervous system myelination (GO:0022010)	2.61594531
87	myoblast migration (GO:0051451)	2.61397430
88	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.58754179
89	histone H2A acetylation (GO:0043968)	2.57701319
90	negative regulation of response to food (GO:0032096)	2.57601508
91	negative regulation of appetite (GO:0032099)	2.57601508
92	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57246271
93	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57246271
94	NADH dehydrogenase complex assembly (GO:0010257)	2.57246271
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.52353827
96	positive regulation of fatty acid transport (GO:2000193)	2.50893711
97	Sertoli cell development (GO:0060009)	2.47313777
98	cellular component biogenesis (GO:0044085)	2.45282168
99	protein targeting (GO:0006605)	2.43097322
100	response to dietary excess (GO:0002021)	2.40413569

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	9.20200356
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97326545
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.92347904
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.45511645
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.33474532
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.30058703
7	VDR_22108803_ChIP-Seq_LS180_Human	2.22333372
8	GATA1_22025678_ChIP-Seq_K562_Human	2.22238333
9	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.20004464
10	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.11376214
11	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.97133890
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.92531168
13	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.84942038
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.84500534
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82097162
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77723452
17	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.73794927
18	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.73794927
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.71023090
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.67966897
21	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.60593380
22	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.55586823
23	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.55240766
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.54780033
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.53994955
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.53139561
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.46736073
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46548193
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45737253
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43313132
31	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.42992147
32	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.41996691
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.41663621
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40742457
35	FUS_26573619_Chip-Seq_HEK293_Human	1.40658956
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38228983
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.33657563
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.33211665
39	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.31618770
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28821939
41	ERA_21632823_ChIP-Seq_H3396_Human	1.28417167
42	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.27765368
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27136767
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26730842
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.25855187
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.23172612
47	BCL6_27268052_Chip-Seq_Bcells_Human	1.22728609
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.20620089
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.18745968
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16426186
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.13390983
52	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.12574896
53	CTCF_27219007_Chip-Seq_Bcells_Human	1.12541709
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12439258
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11762427
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10149418
57	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09842279
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08156643
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07882397
60	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05651479
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.04941171
62	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04770350
63	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04203364
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04147475
65	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.03734870
66	NCOR_22424771_ChIP-Seq_293T_Human	1.02959901
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02841888
68	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.99929694
69	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98370667
70	RAC3_21632823_ChIP-Seq_H3396_Human	0.98020657
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97970200
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96306734
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95778418
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95676414
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95286613
76	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.94895931
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94041443
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93708837
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92919324
80	TP53_22573176_ChIP-Seq_HFKS_Human	0.92611891
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92506108
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92506108
83	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.91710327
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91491730
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91302212
86	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.91153523
87	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.90793198
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90161925
89	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.89906321
90	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89855796
91	EWS_26573619_Chip-Seq_HEK293_Human	0.89451553
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88652077
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.88652077
94	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.88335358
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.88230259
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87961328
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.87743902
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86843250
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.85757443
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.85134313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.90398509
2	MP0006292_abnormal_olfactory_placode	4.24676589
3	MP0001485_abnormal_pinna_reflex	2.98159266
4	MP0003646_muscle_fatigue	2.97934336
5	MP0008877_abnormal_DNA_methylation	2.91760238
6	MP0003136_yellow_coat_color	2.48108357
7	MP0003787_abnormal_imprinting	2.45862129
8	MP0008789_abnormal_olfactory_epithelium	2.29104837
9	MP0002837_dystrophic_cardiac_calcinosis	2.21875483
10	MP0003878_abnormal_ear_physiology	2.09131005
11	MP0005377_hearing/vestibular/ear_phenot	2.09131005
12	MP0006072_abnormal_retinal_apoptosis	2.04217838
13	MP0003122_maternal_imprinting	2.01060910
14	MP0003123_paternal_imprinting	1.96701867
15	MP0004133_heterotaxia	1.92729769
16	MP0005394_taste/olfaction_phenotype	1.88642715
17	MP0005499_abnormal_olfactory_system	1.88642715
18	MP0002234_abnormal_pharynx_morphology	1.87257418
19	MP0001293_anophthalmia	1.86372348
20	MP0002653_abnormal_ependyma_morphology	1.86073130
21	MP0004142_abnormal_muscle_tone	1.75250245
22	MP0000049_abnormal_middle_ear	1.73494186
23	MP0003183_abnormal_peptide_metabolism	1.71846705
24	MP0002733_abnormal_thermal_nociception	1.66823219
25	MP0000778_abnormal_nervous_system	1.66788181
26	MP0003121_genomic_imprinting	1.61116689
27	MP0005551_abnormal_eye_electrophysiolog	1.51381027
28	MP0001968_abnormal_touch/_nociception	1.44872962
29	MP0004147_increased_porphyrin_level	1.42951860
30	MP0005195_abnormal_posterior_eye	1.42918877
31	MP0005645_abnormal_hypothalamus_physiol	1.40628602
32	MP0008995_early_reproductive_senescence	1.38563081
33	MP0006276_abnormal_autonomic_nervous	1.37412416
34	MP0000631_abnormal_neuroendocrine_gland	1.36814999
35	MP0002184_abnormal_innervation	1.36695717
36	MP0005389_reproductive_system_phenotype	1.36001159
37	MP0001919_abnormal_reproductive_system	1.33834691
38	MP0000955_abnormal_spinal_cord	1.32434813
39	MP0001486_abnormal_startle_reflex	1.32130240
40	MP0003879_abnormal_hair_cell	1.32102795
41	MP0008872_abnormal_physiological_respon	1.29865358
42	MP0001986_abnormal_taste_sensitivity	1.28990908
43	MP0002272_abnormal_nervous_system	1.26812801
44	MP0002063_abnormal_learning/memory/cond	1.26766847
45	MP0002735_abnormal_chemical_nociception	1.25823548
46	MP0001970_abnormal_pain_threshold	1.25505575
47	MP0004742_abnormal_vestibular_system	1.25229074
48	MP0002163_abnormal_gland_morphology	1.25088908
49	MP0001440_abnormal_grooming_behavior	1.23454410
50	MP0000604_amyloidosis	1.22323887
51	MP0002102_abnormal_ear_morphology	1.22106090
52	MP0000026_abnormal_inner_ear	1.20685023
53	MP0008775_abnormal_heart_ventricle	1.19243427
54	MP0003635_abnormal_synaptic_transmissio	1.18524061
55	MP0004145_abnormal_muscle_electrophysio	1.16359552
56	MP0001963_abnormal_hearing_physiology	1.12623260
57	MP0004885_abnormal_endolymph	1.08243716
58	MP0003938_abnormal_ear_development	1.07628331
59	MP0004043_abnormal_pH_regulation	1.07094999
60	MP0003786_premature_aging	1.06146674
61	MP0002752_abnormal_somatic_nervous	1.06108053
62	MP0003195_calcinosis	1.04405833
63	MP0002572_abnormal_emotion/affect_behav	1.01855904
64	MP0009745_abnormal_behavioral_response	1.01822025
65	MP0000537_abnormal_urethra_morphology	1.01692100
66	MP0008875_abnormal_xenobiotic_pharmacok	1.01470728
67	MP0000516_abnormal_urinary_system	1.00910187
68	MP0005367_renal/urinary_system_phenotyp	1.00910187
69	MP0005670_abnormal_white_adipose	1.00200873
70	MP0002736_abnormal_nociception_after	1.00001138
71	MP0002557_abnormal_social/conspecific_i	0.99175407
72	MP0009053_abnormal_anal_canal	0.97212540
73	MP0003942_abnormal_urinary_system	0.96628223
74	MP0002638_abnormal_pupillary_reflex	0.94700227
75	MP0000427_abnormal_hair_cycle	0.93846319
76	MP0005397_hematopoietic_system_phenotyp	0.93365368
77	MP0001545_abnormal_hematopoietic_system	0.93365368
78	MP0000372_irregular_coat_pigmentation	0.93073218
79	MP0002160_abnormal_reproductive_system	0.92399751
80	MP0010030_abnormal_orbit_morphology	0.88915748
81	MP0005253_abnormal_eye_physiology	0.88911388
82	MP0002734_abnormal_mechanical_nocicepti	0.87461009
83	MP0003119_abnormal_digestive_system	0.87202425
84	MP0009250_abnormal_appendicular_skeleto	0.85548544
85	MP0002138_abnormal_hepatobiliary_system	0.85025400
86	MP0005646_abnormal_pituitary_gland	0.84494621
87	MP0005423_abnormal_somatic_nervous	0.82678232
88	MP0002882_abnormal_neuron_morphology	0.78917099
89	MP0002067_abnormal_sensory_capabilities	0.77625217
90	MP0000678_abnormal_parathyroid_gland	0.75987558
91	MP0004019_abnormal_vitamin_homeostasis	0.74725307
92	MP0000230_abnormal_systemic_arterial	0.74016769
93	MP0002229_neurodegeneration	0.73067988
94	MP0002064_seizures	0.71782653
95	MP0005391_vision/eye_phenotype	0.71253174
96	MP0002938_white_spotting	0.70839959
97	MP0001905_abnormal_dopamine_level	0.69653250
98	MP0003567_abnormal_fetal_cardiomyocyte	0.69058972
99	MP0001984_abnormal_olfaction	0.68253617
100	MP0000566_synostosis	0.68013265

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.45639756
2	True hermaphroditism (HP:0010459)	4.26425033
3	Septo-optic dysplasia (HP:0100842)	4.24778391
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.24549877
5	Molar tooth sign on MRI (HP:0002419)	4.00764168
6	Abnormality of midbrain morphology (HP:0002418)	4.00764168
7	Pancreatic fibrosis (HP:0100732)	3.78576581
8	Pendular nystagmus (HP:0012043)	3.48666910
9	Pancreatic cysts (HP:0001737)	3.39239811
10	Macrocytic anemia (HP:0001972)	3.36251217
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.21847210
12	Stenosis of the external auditory canal (HP:0000402)	3.16881159
13	Postaxial foot polydactyly (HP:0001830)	2.96668637
14	Optic nerve hypoplasia (HP:0000609)	2.93748592
15	Type II lissencephaly (HP:0007260)	2.87161960
16	Generalized aminoaciduria (HP:0002909)	2.85937064
17	Pallor (HP:0000980)	2.82438908
18	Congenital stationary night blindness (HP:0007642)	2.78850211
19	Abnormal number of erythroid precursors (HP:0012131)	2.75984818
20	Papilledema (HP:0001085)	2.73327451
21	Nephronophthisis (HP:0000090)	2.72234791
22	Tachypnea (HP:0002789)	2.71625864
23	Cystic liver disease (HP:0006706)	2.71435690
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.70712128
25	Medial flaring of the eyebrow (HP:0010747)	2.67229341
26	Myokymia (HP:0002411)	2.66036609
27	Gait imbalance (HP:0002141)	2.64172572
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.63022092
29	Hyperglycinemia (HP:0002154)	2.60765911
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.59884544
31	Abnormality of DNA repair (HP:0003254)	2.58740106
32	Absent septum pellucidum (HP:0001331)	2.56881820
33	Asplenia (HP:0001746)	2.54891047
34	Male pseudohermaphroditism (HP:0000037)	2.54851649
35	Acute necrotizing encephalopathy (HP:0006965)	2.54813694
36	Abnormal hemoglobin (HP:0011902)	2.53234152
37	Absent thumb (HP:0009777)	2.51563571
38	Abolished electroretinogram (ERG) (HP:0000550)	2.51468289
39	Anomalous pulmonary venous return (HP:0010772)	2.51055843
40	Anencephaly (HP:0002323)	2.48862308
41	Chronic hepatic failure (HP:0100626)	2.48000552
42	Acute encephalopathy (HP:0006846)	2.46789298
43	Supernumerary spleens (HP:0009799)	2.45991054
44	Depressed nasal ridge (HP:0000457)	2.44833597
45	Increased corneal curvature (HP:0100692)	2.43039546
46	Keratoconus (HP:0000563)	2.43039546
47	Congenital primary aphakia (HP:0007707)	2.41366218
48	Proximal tubulopathy (HP:0000114)	2.39185387
49	Partial duplication of thumb phalanx (HP:0009944)	2.38203485
50	Sclerocornea (HP:0000647)	2.34460920
51	Failure to thrive in infancy (HP:0001531)	2.32824688
52	Chorioretinal atrophy (HP:0000533)	2.27782595
53	Rib fusion (HP:0000902)	2.27513240
54	Severe visual impairment (HP:0001141)	2.27230918
55	Renal cortical cysts (HP:0000803)	2.26630710
56	Abnormality of the renal medulla (HP:0100957)	2.26559707
57	Abnormality of the pulmonary veins (HP:0011718)	2.18264098
58	Abnormality of the labia minora (HP:0012880)	2.17578515
59	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17247915
60	Nephrogenic diabetes insipidus (HP:0009806)	2.16060019
61	Diaphragmatic weakness (HP:0009113)	2.15478807
62	Congenital hepatic fibrosis (HP:0002612)	2.12499110
63	Hepatic necrosis (HP:0002605)	2.10062206
64	Hypoplasia of the radius (HP:0002984)	2.09012697
65	Progressive macrocephaly (HP:0004481)	2.09010543
66	Poor coordination (HP:0002370)	2.08576768
67	Cerebellar dysplasia (HP:0007033)	2.07979367
68	Abnormality of the renal cortex (HP:0011035)	2.04474641
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03946129
70	Pachygyria (HP:0001302)	2.03493036
71	Vaginal atresia (HP:0000148)	2.03156639
72	Type 2 muscle fiber atrophy (HP:0003554)	2.03064688
73	Anterior segment dysgenesis (HP:0007700)	2.00966126
74	Abnormality of the septum pellucidum (HP:0007375)	1.99841562
75	Hyperventilation (HP:0002883)	1.97007619
76	Mitochondrial inheritance (HP:0001427)	1.94824630
77	Genital tract atresia (HP:0001827)	1.92815268
78	Partial duplication of the phalanx of hand (HP:0009999)	1.92347308
79	Hepatocellular necrosis (HP:0001404)	1.90592775
80	Maternal diabetes (HP:0009800)	1.88639271
81	Oligodactyly (hands) (HP:0001180)	1.86560716
82	Hyperglycinuria (HP:0003108)	1.85934660
83	Abnormal biliary tract physiology (HP:0012439)	1.85347351
84	Bile duct proliferation (HP:0001408)	1.85347351
85	Clumsiness (HP:0002312)	1.81515349
86	Preaxial hand polydactyly (HP:0001177)	1.81099576
87	Abnormality of the anterior horn cell (HP:0006802)	1.80820233
88	Degeneration of anterior horn cells (HP:0002398)	1.80820233
89	Hypochromic microcytic anemia (HP:0004840)	1.80624035
90	Postaxial hand polydactyly (HP:0001162)	1.80417069
91	Glycosuria (HP:0003076)	1.79139021
92	Abnormality of urine glucose concentration (HP:0011016)	1.79139021
93	Left ventricular hypertrophy (HP:0001712)	1.78051853
94	Dry hair (HP:0011359)	1.77850824
95	Synostosis of carpal bones (HP:0005048)	1.77802315
96	Duplication of thumb phalanx (HP:0009942)	1.77695458
97	Holoprosencephaly (HP:0001360)	1.76515657
98	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.76392117
99	Polyphagia (HP:0002591)	1.75553652
100	Muscle fiber atrophy (HP:0100295)	1.75265434

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.13028614
2	ADRBK2	3.37570445
3	TXK	3.19901941
4	FRK	3.03178361
5	WNK4	2.85404551
6	LRRK2	2.17897284
7	DYRK2	2.15606841
8	EPHB2	2.12223877
9	GRK1	2.12207531
10	TYRO3	2.07713768
11	MAP3K11	2.06653306
12	BCKDK	2.00109823
13	CAMKK2	1.99143018
14	DYRK1B	1.90440231
15	STK16	1.81397518
16	NTRK2	1.68072744
17	PAK3	1.63364353
18	PINK1	1.62459415
19	EPHA4	1.60285588
20	STK39	1.52091396
21	WNK3	1.50724993
22	MAP4K1	1.48577558
23	PRKCG	1.48532142
24	MAP2K2	1.47744616
25	NTRK1	1.45727209
26	CAMKK1	1.41719245
27	TNIK	1.41533977
28	TLK1	1.33060313
29	WNK1	1.28940697
30	MARK1	1.24735830
31	AURKA	1.16095792
32	CAMK1	1.11899720
33	PRKCH	1.08097058
34	GRK7	1.03943422
35	STK11	1.02520255
36	CASK	1.01334121
37	MAPK13	0.98513541
38	OXSR1	0.96800216
39	MAP4K2	0.96323657
40	SGK223	0.95906897
41	SGK494	0.95906897
42	PRKCZ	0.95097770
43	MAP3K4	0.92576958
44	ADRBK1	0.91585970
45	PDK2	0.88072190
46	INSRR	0.87787051
47	PRKACA	0.85884045
48	FGFR2	0.84126211
49	RPS6KA6	0.83778034
50	BMPR1B	0.82580817
51	ACVR1B	0.80469314
52	NME1	0.79368120
53	TAOK3	0.76174432
54	RPS6KL1	0.75804962
55	RPS6KC1	0.75804962
56	MATK	0.72427403
57	SGK1	0.71696523
58	MAPK15	0.71502614
59	PAK6	0.68001545
60	CSNK2A2	0.67605148
61	PHKG2	0.65684340
62	PHKG1	0.65684340
63	TNK2	0.65553731
64	PRKCD	0.64972712
65	PRKCQ	0.64172423
66	ERBB3	0.60217970
67	CAMK4	0.57953191
68	MAP2K7	0.57922844
69	PLK4	0.57792529
70	MKNK2	0.57138023
71	MAP2K4	0.55958236
72	PKN1	0.55673833
73	MUSK	0.54335617
74	NTRK3	0.54100789
75	PRKACB	0.53548789
76	OBSCN	0.53432528
77	RPS6KA3	0.52868627
78	ABL2	0.52302291
79	MINK1	0.51803821
80	PRKCI	0.51641919
81	BTK	0.51266574
82	PRKACG	0.49391159
83	DAPK3	0.49179515
84	TIE1	0.47508453
85	PRKCA	0.46043029
86	PLK2	0.44748571
87	SGK2	0.43665801
88	PASK	0.42903863
89	CHEK2	0.42694285
90	AURKB	0.42449789
91	CAMK2A	0.40928050
92	CSNK1E	0.40559811
93	MAP2K1	0.39738737
94	PRKCE	0.38907909
95	CDK5	0.37370080
96	SYK	0.36989234
97	INSR	0.36710154
98	PRKDC	0.36258124
99	KIT	0.35747481
100	SIK2	0.35087169

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.60539046
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93750368
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.80281630
4	Caffeine metabolism_Homo sapiens_hsa00232	2.56258852
5	Parkinsons disease_Homo sapiens_hsa05012	2.43385760
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22962210
7	Nicotine addiction_Homo sapiens_hsa05033	2.11325148
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94714144
9	Alzheimers disease_Homo sapiens_hsa05010	1.90589747
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74835773
11	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.74194962
12	Huntingtons disease_Homo sapiens_hsa05016	1.74143266
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.70700357
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.69792544
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69109189
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68861263
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66105566
18	Phototransduction_Homo sapiens_hsa04744	1.62710595
19	Butanoate metabolism_Homo sapiens_hsa00650	1.57521163
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54856602
21	Taste transduction_Homo sapiens_hsa04742	1.53820801
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40179216
23	Retinol metabolism_Homo sapiens_hsa00830	1.37467317
24	Peroxisome_Homo sapiens_hsa04146	1.35458824
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.35026342
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29684658
27	RNA polymerase_Homo sapiens_hsa03020	1.29436975
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.25628529
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.23842819
30	Propanoate metabolism_Homo sapiens_hsa00640	1.22727423
31	Basal transcription factors_Homo sapiens_hsa03022	1.13703607
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10304530
33	Homologous recombination_Homo sapiens_hsa03440	1.07331092
34	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.04655957
35	Salivary secretion_Homo sapiens_hsa04970	1.02772848
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.01599060
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01098082
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00940215
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00427867
40	Basal cell carcinoma_Homo sapiens_hsa05217	0.99203370
41	Insulin secretion_Homo sapiens_hsa04911	0.97015372
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.94843610
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.92644276
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.92485251
45	Renin-angiotensin system_Homo sapiens_hsa04614	0.92063331
46	Olfactory transduction_Homo sapiens_hsa04740	0.90830511
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.90489694
48	Morphine addiction_Homo sapiens_hsa05032	0.89394590
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.88064815
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87852484
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.86553909
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82042612
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80608723
54	One carbon pool by folate_Homo sapiens_hsa00670	0.79834949
55	Asthma_Homo sapiens_hsa05310	0.77911524
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76676654
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75629496
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.73542516
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73531361
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73149318
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73107352
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70780376
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69672984
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68386285
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68324074
66	Circadian entrainment_Homo sapiens_hsa04713	0.66552823
67	Fatty acid degradation_Homo sapiens_hsa00071	0.65907707
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.64166657
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63947834
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63714041
71	Notch signaling pathway_Homo sapiens_hsa04330	0.62414776
72	Cocaine addiction_Homo sapiens_hsa05030	0.59491030
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.59018242
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.57484443
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.55691994
76	RNA degradation_Homo sapiens_hsa03018	0.54979147
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54147813
78	Metabolic pathways_Homo sapiens_hsa01100	0.53335572
79	ABC transporters_Homo sapiens_hsa02010	0.51447055
80	Serotonergic synapse_Homo sapiens_hsa04726	0.51180456
81	Axon guidance_Homo sapiens_hsa04360	0.50943742
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48263873
83	GABAergic synapse_Homo sapiens_hsa04727	0.47472139
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46632038
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46086645
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45939500
87	Sulfur relay system_Homo sapiens_hsa04122	0.45935934
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43459635
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.42764536
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.40454719
91	Protein export_Homo sapiens_hsa03060	0.38424365
92	Base excision repair_Homo sapiens_hsa03410	0.36818760
93	Regulation of autophagy_Homo sapiens_hsa04140	0.36563657
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35009252
95	Renin secretion_Homo sapiens_hsa04924	0.33456927
96	Cholinergic synapse_Homo sapiens_hsa04725	0.32953450
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31528562
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29837846
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29741275
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.28523420

RPL7P55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »