ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.11304260
2	cytidine metabolic process (GO:0046087)	4.86360802
3	cytidine catabolic process (GO:0006216)	4.86360802
4	cytidine deamination (GO:0009972)	4.86360802
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.65914949
6	ATP synthesis coupled proton transport (GO:0015986)	4.61449143
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.61449143
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.42125791
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.18310080
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.93321897
11	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.86767422
12	ribosomal small subunit assembly (GO:0000028)	3.78034260
13	response to pheromone (GO:0019236)	3.62420472
14	respiratory electron transport chain (GO:0022904)	3.60034771
15	electron transport chain (GO:0022900)	3.56567718
16	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.52346422
17	protein complex biogenesis (GO:0070271)	3.41699785
18	regulation of regulatory T cell differentiation (GO:0045589)	3.41223776
19	regulation of isotype switching to IgG isotypes (GO:0048302)	3.38323402
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.32583909
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.32583909
22	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.28841772
23	ribosomal large subunit biogenesis (GO:0042273)	3.25643929
24	protein neddylation (GO:0045116)	3.23730899
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18675606
26	kynurenine metabolic process (GO:0070189)	3.13698439
27	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09923456
28	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.04238585
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03672980
30	viral transcription (GO:0019083)	3.00419340
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99181230
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99181230
33	NADH dehydrogenase complex assembly (GO:0010257)	2.99181230
34	indole-containing compound catabolic process (GO:0042436)	2.97868622
35	indolalkylamine catabolic process (GO:0046218)	2.97868622
36	tryptophan catabolic process (GO:0006569)	2.97868622
37	regulation of T cell mediated cytotoxicity (GO:0001914)	2.95678182
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.92370799
39	GTP biosynthetic process (GO:0006183)	2.92237832
40	respiratory chain complex IV assembly (GO:0008535)	2.92227389
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92099810
42	regulation of cellular amino acid metabolic process (GO:0006521)	2.91418200
43	positive regulation of defense response to virus by host (GO:0002230)	2.91276386
44	tryptophan metabolic process (GO:0006568)	2.90368018
45	maturation of SSU-rRNA (GO:0030490)	2.89637394
46	cytochrome complex assembly (GO:0017004)	2.88255013
47	positive T cell selection (GO:0043368)	2.86505010
48	translational termination (GO:0006415)	2.85682374
49	negative regulation of mast cell activation (GO:0033004)	2.84086901
50	positive thymic T cell selection (GO:0045059)	2.83268107
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82415122
52	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.81166986
53	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.79107687
54	translational elongation (GO:0006414)	2.78513546
55	hydrogen ion transmembrane transport (GO:1902600)	2.77271980
56	positive regulation of cell killing (GO:0031343)	2.76625771
57	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.74903521
58	mast cell activation (GO:0045576)	2.74544165
59	protein-cofactor linkage (GO:0018065)	2.72595303
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71527815
61	termination of RNA polymerase III transcription (GO:0006386)	2.71527815
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.71349400
63	regulation of chronic inflammatory response (GO:0002676)	2.71244936
64	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.70739971
65	negative regulation of heart rate (GO:0010459)	2.69983278
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.68974541
67	positive regulation of protein homodimerization activity (GO:0090073)	2.68951617
68	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68424475
69	platelet dense granule organization (GO:0060155)	2.67671742
70	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.66572257
71	proton transport (GO:0015992)	2.66453713
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66390300
73	L-fucose catabolic process (GO:0042355)	2.65950034
74	fucose catabolic process (GO:0019317)	2.65950034
75	L-fucose metabolic process (GO:0042354)	2.65950034
76	regulation of activation of Janus kinase activity (GO:0010533)	2.65889107
77	cotranslational protein targeting to membrane (GO:0006613)	2.65269535
78	protein targeting to ER (GO:0045047)	2.64509969
79	water-soluble vitamin biosynthetic process (GO:0042364)	2.64345168
80	positive regulation of prostaglandin secretion (GO:0032308)	2.64318402
81	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.63992607
82	hydrogen transport (GO:0006818)	2.63668684
83	positive regulation of B cell mediated immunity (GO:0002714)	2.63639658
84	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.63639658
85	maturation of 5.8S rRNA (GO:0000460)	2.63592219
86	behavioral response to nicotine (GO:0035095)	2.63524962
87	ATP biosynthetic process (GO:0006754)	2.61628238
88	positive regulation of DNA recombination (GO:0045911)	2.60995696
89	indolalkylamine metabolic process (GO:0006586)	2.60029283
90	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.59434758
91	cellular response to interleukin-15 (GO:0071350)	2.58918624
92	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.57617507
93	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.57169399
94	regulation of memory T cell differentiation (GO:0043380)	2.56734570
95	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.56260554
96	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.56260554
97	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.56260554
98	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.54732237
99	positive regulation of isotype switching (GO:0045830)	2.54243388
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.54243017

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.66849181
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.30436330
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.92099372
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.87314112
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.83634779
6	VDR_22108803_ChIP-Seq_LS180_Human	2.81433711
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.78154640
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76734611
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.65232334
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.48525836
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48511050
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30668341
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.26699774
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.22011972
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.21518680
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20172839
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.17918493
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11901790
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.06642772
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05347655
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.91528330
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84618746
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83525662
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.76773736
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76132750
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69972806
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63691881
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.63689789
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.59046317
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58582316
31	GATA3_26560356_Chip-Seq_TH2_Human	1.56857622
32	EWS_26573619_Chip-Seq_HEK293_Human	1.53811438
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.51125015
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50282319
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50282319
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49371641
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48216603
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.48166951
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.48156949
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46644703
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46614281
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46614281
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44034293
44	MYB_26560356_Chip-Seq_TH2_Human	1.43413878
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39584680
46	AR_20517297_ChIP-Seq_VCAP_Human	1.39556499
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.37795027
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35812865
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35702991
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.31269713
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28187681
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27780981
53	FUS_26573619_Chip-Seq_HEK293_Human	1.26492664
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26473343
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25567294
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24844953
57	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24581715
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24125318
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.23872493
60	P300_19829295_ChIP-Seq_ESCs_Human	1.23019231
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22763224
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22734755
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20623500
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.20561410
65	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20231019
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19345452
67	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19300048
68	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18144986
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.17764060
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17764060
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17750125
72	NCOR_22424771_ChIP-Seq_293T_Human	1.17610350
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16756717
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14475912
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13275427
76	GATA3_27048872_Chip-Seq_THYMUS_Human	1.11542945
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10221630
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.08564396
79	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07591712
80	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.06299531
81	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.04987555
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04855426
83	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04364049
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03944754
85	GBX2_23144817_ChIP-Seq_PC3_Human	1.03755968
86	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03559622
87	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.02931522
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02426977
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01639495
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01531792
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00384853
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98064822
93	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.97737660
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97265648
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.95922093
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94097815
97	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93346655
98	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93086447
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92214846
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91470439

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.84657513
2	MP0001835_abnormal_antigen_presentation	4.52976618
3	MP0009785_altered_susceptibility_to	2.62831922
4	MP0002166_altered_tumor_susceptibility	2.36984371
5	MP0002006_tumorigenesis	2.10135554
6	MP0009333_abnormal_splenocyte_physiolog	2.10101693
7	MP0008875_abnormal_xenobiotic_pharmacok	2.09287985
8	MP0006292_abnormal_olfactory_placode	2.06942815
9	MP0001800_abnormal_humoral_immune	2.05235456
10	MP0002148_abnormal_hypersensitivity_rea	2.03393195
11	MP0006072_abnormal_retinal_apoptosis	2.00742283
12	MP0002102_abnormal_ear_morphology	1.99945323
13	MP0008872_abnormal_physiological_respon	1.95137619
14	MP0001873_stomach_inflammation	1.91423184
15	MP0005000_abnormal_immune_tolerance	1.90621231
16	MP0003806_abnormal_nucleotide_metabolis	1.89839283
17	MP0005387_immune_system_phenotype	1.86476398
18	MP0001790_abnormal_immune_system	1.86476398
19	MP0005645_abnormal_hypothalamus_physiol	1.83842743
20	MP0009379_abnormal_foot_pigmentation	1.82389228
21	MP0000685_abnormal_immune_system	1.81693631
22	MP0002837_dystrophic_cardiac_calcinosis	1.77807525
23	MP0002138_abnormal_hepatobiliary_system	1.77734153
24	MP0003763_abnormal_thymus_physiology	1.76645127
25	MP0003646_muscle_fatigue	1.65505143
26	MP0005551_abnormal_eye_electrophysiolog	1.64429124
27	MP0002723_abnormal_immune_serum	1.64309382
28	MP0005084_abnormal_gallbladder_morpholo	1.64032897
29	MP0005646_abnormal_pituitary_gland	1.61761820
30	MP0004147_increased_porphyrin_level	1.60095214
31	MP0008877_abnormal_DNA_methylation	1.57139689
32	MP0003866_abnormal_defecation	1.54186388
33	MP0003011_delayed_dark_adaptation	1.47800339
34	MP0002420_abnormal_adaptive_immunity	1.47111311
35	MP0001819_abnormal_immune_cell	1.46535026
36	MP0005075_abnormal_melanosome_morpholog	1.45463987
37	MP0002452_abnormal_antigen_presenting	1.44519609
38	MP0003878_abnormal_ear_physiology	1.43379338
39	MP0005377_hearing/vestibular/ear_phenot	1.43379338
40	MP0002876_abnormal_thyroid_physiology	1.39993189
41	MP0002736_abnormal_nociception_after	1.39625024
42	MP0001986_abnormal_taste_sensitivity	1.39224971
43	MP0001968_abnormal_touch/_nociception	1.36379089
44	MP0004145_abnormal_muscle_electrophysio	1.35017218
45	MP0005025_abnormal_response_to	1.32904146
46	MP0003252_abnormal_bile_duct	1.32656344
47	MP0006036_abnormal_mitochondrial_physio	1.26434452
48	MP0001905_abnormal_dopamine_level	1.24998009
49	MP0003195_calcinosis	1.22559367
50	MP0005253_abnormal_eye_physiology	1.21512369
51	MP0002277_abnormal_respiratory_mucosa	1.21112356
52	MP0010155_abnormal_intestine_physiology	1.19065816
53	MP0006082_CNS_inflammation	1.18684271
54	MP0009764_decreased_sensitivity_to	1.17951568
55	MP0004885_abnormal_endolymph	1.16395673
56	MP0004142_abnormal_muscle_tone	1.12609957
57	MP0000716_abnormal_immune_system	1.06261430
58	MP0001845_abnormal_inflammatory_respons	1.05653114
59	MP0006276_abnormal_autonomic_nervous	1.05405893
60	MP0002163_abnormal_gland_morphology	1.04057239
61	MP0005410_abnormal_fertilization	1.03975241
62	MP0002405_respiratory_system_inflammati	1.03807831
63	MP0002398_abnormal_bone_marrow	1.03315987
64	MP0005636_abnormal_mineral_homeostasis	1.02921086
65	MP0003880_abnormal_central_pattern	1.00287684
66	MP0003786_premature_aging	1.00047498
67	MP0005389_reproductive_system_phenotype	0.99620597
68	MP0000372_irregular_coat_pigmentation	0.98851647
69	MP0001984_abnormal_olfaction	0.97955839
70	MP0001919_abnormal_reproductive_system	0.96704585
71	MP0000689_abnormal_spleen_morphology	0.95745249
72	MP0002272_abnormal_nervous_system	0.94959421
73	MP0001501_abnormal_sleep_pattern	0.94787094
74	MP0005085_abnormal_gallbladder_physiolo	0.92693855
75	MP0008775_abnormal_heart_ventricle	0.92568111
76	MP0008469_abnormal_protein_level	0.91776712
77	MP0004742_abnormal_vestibular_system	0.91629277
78	MP0001765_abnormal_ion_homeostasis	0.89421051
79	MP0002693_abnormal_pancreas_physiology	0.87617485
80	MP0009745_abnormal_behavioral_response	0.87490853
81	MP0001485_abnormal_pinna_reflex	0.86028233
82	MP0008007_abnormal_cellular_replicative	0.83322965
83	MP0005670_abnormal_white_adipose	0.83064362
84	MP0008995_early_reproductive_senescence	0.81635910
85	MP0003724_increased_susceptibility_to	0.80330162
86	MP0002160_abnormal_reproductive_system	0.78747383
87	MP0005332_abnormal_amino_acid	0.78018289
88	MP0002429_abnormal_blood_cell	0.77696339
89	MP0000631_abnormal_neuroendocrine_gland	0.76427044
90	MP0010386_abnormal_urinary_bladder	0.75517037
91	MP0002419_abnormal_innate_immunity	0.75128176
92	MP0005319_abnormal_enzyme/_coenzyme	0.75083703
93	MP0000703_abnormal_thymus_morphology	0.73284807
94	MP0009046_muscle_twitch	0.72041999
95	MP0002638_abnormal_pupillary_reflex	0.72018888
96	MP0006035_abnormal_mitochondrial_morpho	0.71909961
97	MP0001970_abnormal_pain_threshold	0.70502625
98	MP0002933_joint_inflammation	0.69590595
99	MP0002722_abnormal_immune_system	0.69563033
100	MP0001764_abnormal_homeostasis	0.68188240

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.33145066
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.83910067
3	Acute necrotizing encephalopathy (HP:0006965)	3.82612514
4	Mitochondrial inheritance (HP:0001427)	3.81380794
5	Congenital stationary night blindness (HP:0007642)	3.71755884
6	IgG deficiency (HP:0004315)	3.68869708
7	Hypoproteinemia (HP:0003075)	3.45751127
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.41586789
9	Absent/shortened dynein arms (HP:0200106)	3.41586789
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.35745315
11	Progressive macrocephaly (HP:0004481)	3.35298536
12	Increased CSF lactate (HP:0002490)	3.34483657
13	Hepatocellular necrosis (HP:0001404)	3.33450874
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.33213290
15	Acute encephalopathy (HP:0006846)	3.25984851
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14810007
17	Increased hepatocellular lipid droplets (HP:0006565)	3.14117127
18	3-Methylglutaconic aciduria (HP:0003535)	3.05849174
19	Stomatitis (HP:0010280)	3.00890923
20	Pancreatic cysts (HP:0001737)	2.98408774
21	Decreased central vision (HP:0007663)	2.98011637
22	Hepatic necrosis (HP:0002605)	2.96605342
23	Abolished electroretinogram (ERG) (HP:0000550)	2.86176814
24	Lipid accumulation in hepatocytes (HP:0006561)	2.84593707
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.81119965
26	Increased IgM level (HP:0003496)	2.79894014
27	Renal Fanconi syndrome (HP:0001994)	2.72542374
28	T lymphocytopenia (HP:0005403)	2.71635663
29	Abnormality of T cell number (HP:0011839)	2.70801214
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.67729354
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.67729354
32	Attenuation of retinal blood vessels (HP:0007843)	2.67474518
33	Increased intramyocellular lipid droplets (HP:0012240)	2.65014231
34	Optic disc pallor (HP:0000543)	2.62641401
35	Abnormal ciliary motility (HP:0012262)	2.54632081
36	Abnormality of midbrain morphology (HP:0002418)	2.53691998
37	Molar tooth sign on MRI (HP:0002419)	2.53691998
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.53309603
39	Methylmalonic acidemia (HP:0002912)	2.53095214
40	Cerebral edema (HP:0002181)	2.52204727
41	Pancreatic fibrosis (HP:0100732)	2.51073756
42	Congenital, generalized hypertrichosis (HP:0004540)	2.50477919
43	Abnormality of the prostate (HP:0008775)	2.47388068
44	Renal cortical cysts (HP:0000803)	2.47318756
45	Abnormality of the renal cortex (HP:0011035)	2.46246085
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43201659
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.42249383
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42249383
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.42239507
50	Severe combined immunodeficiency (HP:0004430)	2.42189974
51	Thyroiditis (HP:0100646)	2.42187318
52	Nephronophthisis (HP:0000090)	2.33464070
53	Increased serum lactate (HP:0002151)	2.31273299
54	Abnormality of B cell number (HP:0010975)	2.30906037
55	True hermaphroditism (HP:0010459)	2.27448792
56	Abnormality of T cells (HP:0002843)	2.26727645
57	Autoimmune hemolytic anemia (HP:0001890)	2.26644513
58	Exertional dyspnea (HP:0002875)	2.23552678
59	Lactic acidosis (HP:0003128)	2.22888944
60	Cerebral palsy (HP:0100021)	2.12752613
61	Increased muscle lipid content (HP:0009058)	2.11927932
62	Abnormal drinking behavior (HP:0030082)	2.10934991
63	Polydipsia (HP:0001959)	2.10934991
64	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09765750
65	Generalized aminoaciduria (HP:0002909)	2.08973134
66	Increased corneal curvature (HP:0100692)	2.07391757
67	Keratoconus (HP:0000563)	2.07391757
68	Type 2 muscle fiber atrophy (HP:0003554)	2.07251010
69	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.06686391
70	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05469613
71	Pancytopenia (HP:0001876)	2.03005186
72	Encephalitis (HP:0002383)	2.02100600
73	Abnormality of the renal medulla (HP:0100957)	2.01935358
74	Abnormal biliary tract physiology (HP:0012439)	2.01123413
75	Bile duct proliferation (HP:0001408)	2.01123413
76	Chronic sinusitis (HP:0011109)	2.00552896
77	Type II lissencephaly (HP:0007260)	2.00146399
78	Abnormality of urine glucose concentration (HP:0011016)	1.99941417
79	Glycosuria (HP:0003076)	1.99941417
80	Constricted visual fields (HP:0001133)	1.98699309
81	Abnormality of eosinophils (HP:0001879)	1.98176512
82	Pendular nystagmus (HP:0012043)	1.95141725
83	Methylmalonic aciduria (HP:0012120)	1.94339650
84	Polyuria (HP:0000103)	1.92960825
85	Retrobulbar optic neuritis (HP:0100654)	1.89640339
86	Optic neuritis (HP:0100653)	1.89640339
87	Supernumerary spleens (HP:0009799)	1.87554847
88	Abnormal number of erythroid precursors (HP:0012131)	1.87281685
89	Hypoalbuminemia (HP:0003073)	1.86298205
90	Abnormal albumin level (HP:0012116)	1.86298205
91	Hypothermia (HP:0002045)	1.86097581
92	Respiratory failure (HP:0002878)	1.85783063
93	Hypoplasia of the uterus (HP:0000013)	1.85424886
94	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.83893128
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.82803368
96	Abnormality of renal resorption (HP:0011038)	1.81463176
97	Agammaglobulinemia (HP:0004432)	1.81292964
98	Hemoptysis (HP:0002105)	1.80998223
99	Lethargy (HP:0001254)	1.79942393
100	Chronic diarrhea (HP:0002028)	1.79463739

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.30241077
2	CDK19	3.38671499
3	KDR	2.84826118
4	FRK	2.71216443
5	MAP3K12	2.63360983
6	GRK1	2.56689096
7	TLK1	2.50250360
8	NUAK1	2.38683673
9	ADRBK2	2.37721180
10	ZAK	2.34619693
11	TESK2	2.25570592
12	TAOK3	2.23608662
13	MAP4K1	2.04806258
14	VRK2	1.99462318
15	BCKDK	1.86659492
16	EIF2AK3	1.75455614
17	ITK	1.70372493
18	PASK	1.64182023
19	PINK1	1.57486636
20	MAP4K2	1.56214468
21	TEC	1.48695761
22	OXSR1	1.46608457
23	SYK	1.45941656
24	KIT	1.44935504
25	BMPR2	1.39245009
26	WNK4	1.36661568
27	VRK1	1.34902584
28	MYLK	1.33154131
29	MST4	1.27655815
30	CSF1R	1.25291377
31	WNK3	1.24573739
32	MUSK	1.22577906
33	DAPK1	1.15214220
34	BTK	1.12113513
35	PIK3CA	1.10476220
36	IKBKB	1.10088819
37	STK16	1.06600838
38	INSRR	1.02629692
39	NME1	0.98106383
40	BUB1	0.97424604
41	MAP2K6	0.95903118
42	FES	0.93395251
43	TRIM28	0.91154109
44	ERBB3	0.90365838
45	TIE1	0.89726716
46	PRKCQ	0.87821242
47	TNK2	0.87250765
48	RPS6KA5	0.85223288
49	LCK	0.84536098
50	JAK3	0.83690654
51	LYN	0.83138327
52	SCYL2	0.82970263
53	STK39	0.82032777
54	DYRK2	0.80315131
55	GRK7	0.77617362
56	GRK6	0.76708297
57	PHKG2	0.76687790
58	PHKG1	0.76687790
59	DAPK2	0.76003158
60	BMPR1B	0.75806452
61	PIK3CG	0.74663035
62	IGF1R	0.69419522
63	ILK	0.68109871
64	OBSCN	0.67408525
65	MAPKAPK3	0.67149844
66	CAMKK2	0.65791556
67	ADRBK1	0.64399234
68	TRPM7	0.63130611
69	CAMKK1	0.62880147
70	PRKCE	0.57295954
71	CSNK1G3	0.56792415
72	CSNK1G2	0.56141224
73	MAP2K7	0.56072458
74	SRPK1	0.55978421
75	IKBKE	0.53920468
76	EIF2AK1	0.52908888
77	MAP3K4	0.52225872
78	FLT3	0.52005877
79	CDK3	0.51479393
80	PLK2	0.49009196
81	PRKCA	0.47724588
82	PRKCG	0.47689984
83	DAPK3	0.47401572
84	MAPK13	0.46581844
85	HCK	0.45988653
86	PRKACA	0.45754238
87	NME2	0.44566464
88	EIF2AK2	0.42888286
89	ACVR1B	0.42447473
90	FGFR2	0.41144777
91	MAP3K11	0.39976685
92	ROCK1	0.39002227
93	MAP3K14	0.35718294
94	PRKG1	0.35075096
95	ABL1	0.35015087
96	RPS6KA4	0.34858106
97	CSNK1G1	0.34689017
98	PLK3	0.33971716
99	PRKCD	0.33830133
100	CSNK2A1	0.33591593

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.89722636
2	Proteasome_Homo sapiens_hsa03050	3.60854789
3	Allograft rejection_Homo sapiens_hsa05330	3.56966347
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.32133529
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.19989128
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19714250
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.92375328
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.90863715
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90492626
10	Ribosome_Homo sapiens_hsa03010	2.80101684
11	Parkinsons disease_Homo sapiens_hsa05012	2.56615736
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.29525562
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.04777916
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81684274
15	Protein export_Homo sapiens_hsa03060	1.74544586
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.73532835
17	RNA polymerase_Homo sapiens_hsa03020	1.73232464
18	Alzheimers disease_Homo sapiens_hsa05010	1.65835774
19	Phototransduction_Homo sapiens_hsa04744	1.61957516
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54634223
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53763428
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52942513
23	Caffeine metabolism_Homo sapiens_hsa00232	1.52851988
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50539144
25	Huntingtons disease_Homo sapiens_hsa05016	1.47803935
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.45068450
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36620600
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34457124
29	One carbon pool by folate_Homo sapiens_hsa00670	1.29580322
30	Viral myocarditis_Homo sapiens_hsa05416	1.20767183
31	RNA degradation_Homo sapiens_hsa03018	1.20570176
32	Homologous recombination_Homo sapiens_hsa03440	1.16053606
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12257257
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.08990643
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06937297
36	Peroxisome_Homo sapiens_hsa04146	1.01356473
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.00531914
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99689355
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.99187265
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.94960810
41	Butanoate metabolism_Homo sapiens_hsa00650	0.93696262
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.92641346
43	Olfactory transduction_Homo sapiens_hsa04740	0.91515989
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90989161
45	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.88284894
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88203847
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87513250
48	Propanoate metabolism_Homo sapiens_hsa00640	0.86835023
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.84761358
50	Retinol metabolism_Homo sapiens_hsa00830	0.82627453
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81814953
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78704605
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.76619835
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73318555
55	Basal transcription factors_Homo sapiens_hsa03022	0.73243506
56	Leishmaniasis_Homo sapiens_hsa05140	0.70493306
57	Purine metabolism_Homo sapiens_hsa00230	0.69083012
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.68251007
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66868634
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64033631
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63473250
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60485557
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59370878
64	Regulation of autophagy_Homo sapiens_hsa04140	0.56520830
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56137064
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54963650
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53157854
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.51458614
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50803069
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49898874
71	Taste transduction_Homo sapiens_hsa04742	0.49689620
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49348910
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47859172
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46822786
75	Sulfur metabolism_Homo sapiens_hsa00920	0.46262318
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.46050810
77	Metabolic pathways_Homo sapiens_hsa01100	0.45297316
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44844392
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.44733307
80	Nicotine addiction_Homo sapiens_hsa05033	0.44630003
81	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43039110
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39783857
83	Morphine addiction_Homo sapiens_hsa05032	0.39207969
84	Malaria_Homo sapiens_hsa05144	0.38859571
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33415495
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.32601155
87	Herpes simplex infection_Homo sapiens_hsa05168	0.32521334
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30819178
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.30386950
90	Measles_Homo sapiens_hsa05162	0.27969272
91	Salivary secretion_Homo sapiens_hsa04970	0.27020374
92	African trypanosomiasis_Homo sapiens_hsa05143	0.26885421
93	Spliceosome_Homo sapiens_hsa03040	0.24773919
94	RNA transport_Homo sapiens_hsa03013	0.24078488
95	GABAergic synapse_Homo sapiens_hsa04727	0.22038820
96	Fatty acid degradation_Homo sapiens_hsa00071	0.18966357
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.16956422
98	Serotonergic synapse_Homo sapiens_hsa04726	0.16934030
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.16569849
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.16268303

RPL7P56

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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