RPL7P57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)9.67658883
2cytidine deamination (GO:0009972)9.67658883
3cytidine metabolic process (GO:0046087)9.67658883
4pyrimidine ribonucleoside catabolic process (GO:0046133)8.97384212
5DNA deamination (GO:0045006)7.94037739
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.36775840
7cellular ketone body metabolic process (GO:0046950)5.36757880
8regulation of chronic inflammatory response (GO:0002676)5.22670315
9regulation of activation of Janus kinase activity (GO:0010533)5.08007329
10signal peptide processing (GO:0006465)4.89285739
11ketone body metabolic process (GO:1902224)4.84623120
12auditory receptor cell differentiation (GO:0042491)4.57844656
13rRNA catabolic process (GO:0016075)4.50845862
14eosinophil chemotaxis (GO:0048245)4.39004673
15positive regulation of defense response to virus by host (GO:0002230)4.21795119
16ether lipid metabolic process (GO:0046485)4.20758079
17negative regulation by host of viral transcription (GO:0043922)4.14732865
18pyrimidine nucleoside catabolic process (GO:0046135)4.04597741
19eosinophil migration (GO:0072677)3.96349367
20UDP-N-acetylglucosamine metabolic process (GO:0006047)3.90964132
21respiratory chain complex IV assembly (GO:0008535)3.82391966
22DNA demethylation (GO:0080111)3.77383720
23regulation of T cell chemotaxis (GO:0010819)3.76313172
24positive regulation of T cell chemotaxis (GO:0010820)3.76313172
25cytochrome complex assembly (GO:0017004)3.74354044
26negative regulation of viral genome replication (GO:0045071)3.72530617
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49179742
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47014227
29pyrimidine ribonucleoside metabolic process (GO:0046131)3.35981516
30L-phenylalanine catabolic process (GO:0006559)3.35332407
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.35332407
32negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34881665
33regulation of B cell receptor signaling pathway (GO:0050855)3.34849126
34activated T cell proliferation (GO:0050798)3.33656324
35regulation of lymphocyte chemotaxis (GO:1901623)3.29261370
36intestinal epithelial cell development (GO:0060576)3.23307705
37protein complex biogenesis (GO:0070271)3.22358938
38DNA double-strand break processing (GO:0000729)3.15975459
39pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.14971251
40UMP metabolic process (GO:0046049)3.14971251
41pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.14971251
42UMP biosynthetic process (GO:0006222)3.14971251
43positive regulation of interleukin-8 secretion (GO:2000484)3.09024408
44cellular response to interleukin-15 (GO:0071350)3.08797290
45positive regulation of monocyte chemotaxis (GO:0090026)3.07081387
46DNA dealkylation (GO:0035510)3.02441966
47positive regulation of translational initiation (GO:0045948)3.01582459
48negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.99576844
49protein neddylation (GO:0045116)2.98761175
50production of molecular mediator involved in inflammatory response (GO:0002532)2.98309419
51mitochondrial respiratory chain complex assembly (GO:0033108)2.90837993
52aggressive behavior (GO:0002118)2.90621668
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90084450
54L-phenylalanine metabolic process (GO:0006558)2.90084450
55negative regulation of T cell apoptotic process (GO:0070233)2.89828890
56nucleotide transmembrane transport (GO:1901679)2.88367486
57positive regulation of amino acid transport (GO:0051957)2.86490941
58fatty acid transmembrane transport (GO:1902001)2.83099875
59regulation of viral genome replication (GO:0045069)2.82780389
60glycerol ether metabolic process (GO:0006662)2.81084811
61atrial cardiac muscle cell action potential (GO:0086014)2.78171343
62pteridine-containing compound biosynthetic process (GO:0042559)2.73786043
63potassium ion import (GO:0010107)2.73156428
64positive regulation of natural killer cell differentiation (GO:0032825)2.72582281
65regulation of macrophage chemotaxis (GO:0010758)2.71411761
66negative regulation of viral transcription (GO:0032897)2.70505944
67rRNA modification (GO:0000154)2.69607744
68macrophage chemotaxis (GO:0048246)2.68625011
69urate metabolic process (GO:0046415)2.66137930
70regulation of memory T cell differentiation (GO:0043380)2.65429185
71positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.63983577
72ether metabolic process (GO:0018904)2.63356219
73positive regulation of interleukin-17 production (GO:0032740)2.63035987
74positive regulation of natural killer cell mediated immunity (GO:0002717)2.62816700
75nucleotide-sugar biosynthetic process (GO:0009226)2.60635611
76regulation of defense response to virus by host (GO:0050691)2.55638077
77kidney morphogenesis (GO:0060993)2.53797242
78positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.53531695
79positive regulation of T cell apoptotic process (GO:0070234)2.52725011
80regulation of regulatory T cell differentiation (GO:0045589)2.52724682
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49659854
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.49659854
83NADH dehydrogenase complex assembly (GO:0010257)2.49659854
84regulation of chemokine-mediated signaling pathway (GO:0070099)2.48814927
85water-soluble vitamin biosynthetic process (GO:0042364)2.46730383
86negative regulation of viral process (GO:0048525)2.44805712
87negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44215288
88glycosphingolipid biosynthetic process (GO:0006688)2.42997342
89branched-chain amino acid catabolic process (GO:0009083)2.42996350
90seminiferous tubule development (GO:0072520)2.42759843
91ncRNA catabolic process (GO:0034661)2.42433879
92transcription from mitochondrial promoter (GO:0006390)2.41717535
93heme transport (GO:0015886)2.41380979
94regulation of meiosis I (GO:0060631)2.40449259
95pseudouridine synthesis (GO:0001522)2.39527363
96negative regulation of B cell proliferation (GO:0030889)2.39510327
97response to interleukin-15 (GO:0070672)2.39329661
98regulation of mononuclear cell migration (GO:0071675)2.39032387
99positive regulation of lymphocyte migration (GO:2000403)2.38339291
100postreplication repair (GO:0006301)2.38250373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.97821608
2GATA1_22025678_ChIP-Seq_K562_Human4.49857842
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31641016
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03770921
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.79247243
6TAF15_26573619_Chip-Seq_HEK293_Human2.92033980
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64606581
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54652517
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48900011
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.40105200
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35842345
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34882458
13GBX2_23144817_ChIP-Seq_PC3_Human2.28811354
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27455223
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25960918
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.25726463
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14042360
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08266941
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.04935966
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.02955779
21FUS_26573619_Chip-Seq_HEK293_Human2.00836583
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86735997
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.75725941
24EWS_26573619_Chip-Seq_HEK293_Human1.74603031
25TP53_22573176_ChIP-Seq_HFKS_Human1.72897111
26IGF1R_20145208_ChIP-Seq_DFB_Human1.71832440
27ZNF274_21170338_ChIP-Seq_K562_Hela1.71693271
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71350752
29P300_19829295_ChIP-Seq_ESCs_Human1.70237688
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68251875
31ER_23166858_ChIP-Seq_MCF-7_Human1.66126999
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63180520
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57042609
34VDR_23849224_ChIP-Seq_CD4+_Human1.56806298
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.54636018
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.51489373
37ELK1_19687146_ChIP-ChIP_HELA_Human1.50251054
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49990557
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49053074
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47037222
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.45290359
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43435506
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43349700
44VDR_22108803_ChIP-Seq_LS180_Human1.41160502
45BCAT_22108803_ChIP-Seq_LS180_Human1.38706103
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.37204919
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.35089920
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.32096358
49FOXP3_21729870_ChIP-Seq_TREG_Human1.31585403
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31440822
51MYB_26560356_Chip-Seq_TH2_Human1.29206485
52SMAD4_21799915_ChIP-Seq_A2780_Human1.27247889
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26810060
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25091412
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22176197
56HTT_18923047_ChIP-ChIP_STHdh_Human1.21544101
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21417512
58SOX2_19829295_ChIP-Seq_ESCs_Human1.21390245
59NANOG_19829295_ChIP-Seq_ESCs_Human1.21390245
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20234984
61CBP_20019798_ChIP-Seq_JUKART_Human1.20234984
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20090534
63GATA3_26560356_Chip-Seq_TH2_Human1.20002161
64RUNX_20019798_ChIP-Seq_JUKART_Human1.19261495
65AR_25329375_ChIP-Seq_VCAP_Human1.19155062
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.17791022
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17547563
68TCF4_22108803_ChIP-Seq_LS180_Human1.14004020
69GATA3_27048872_Chip-Seq_THYMUS_Human1.13843580
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.13788639
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12536688
72MYC_18940864_ChIP-ChIP_HL60_Human1.12127231
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.10697592
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10697592
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10446433
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08981265
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.08639133
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.07888195
79AR_20517297_ChIP-Seq_VCAP_Human1.07700731
80CDX2_22108803_ChIP-Seq_LS180_Human1.07050299
81MYB_26560356_Chip-Seq_TH1_Human1.05726711
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05206262
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.04578892
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04489766
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04467318
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03841450
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03681334
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02159995
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00007843
90STAT3_23295773_ChIP-Seq_U87_Human0.97178321
91TCF4_23295773_ChIP-Seq_U87_Human0.97044353
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96047931
93STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95833191
94PHF8_20622853_ChIP-Seq_HELA_Human0.94329651
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93522320
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93522320
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93435437
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92206772
99P300_18555785_Chip-Seq_ESCs_Mouse0.91684227
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88725760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.98148445
2MP0008057_abnormal_DNA_replication4.52893409
3MP0005174_abnormal_tail_pigmentation3.82103021
4MP0002254_reproductive_system_inflammat3.58161177
5MP0002163_abnormal_gland_morphology3.14277697
6MP0005671_abnormal_response_to2.99149443
7MP0005645_abnormal_hypothalamus_physiol2.90240163
8MP0003136_yellow_coat_color2.76806508
9MP0005379_endocrine/exocrine_gland_phen2.35185875
10MP0008877_abnormal_DNA_methylation2.23591919
11MP0001188_hyperpigmentation2.22247547
12MP0002090_abnormal_vision2.14892181
13MP0002938_white_spotting2.05591518
14MP0005084_abnormal_gallbladder_morpholo2.03895877
15MP0002837_dystrophic_cardiac_calcinosis1.99372761
16MP0004147_increased_porphyrin_level1.97966854
17MP0003195_calcinosis1.90407126
18MP0000569_abnormal_digit_pigmentation1.88299315
19MP0002095_abnormal_skin_pigmentation1.84041146
20MP0003787_abnormal_imprinting1.79505699
21MP0000013_abnormal_adipose_tissue1.77066684
22MP0003763_abnormal_thymus_physiology1.68718701
23MP0004381_abnormal_hair_follicle1.66760665
24MP0001835_abnormal_antigen_presentation1.65929847
25MP0006082_CNS_inflammation1.57757346
26MP0005220_abnormal_exocrine_pancreas1.54390794
27MP0000015_abnormal_ear_pigmentation1.49255050
28MP0006054_spinal_hemorrhage1.46779604
29MP0008058_abnormal_DNA_repair1.46659907
30MP0002132_abnormal_respiratory_system1.44308317
31MP0002166_altered_tumor_susceptibility1.43865733
32MP0002148_abnormal_hypersensitivity_rea1.26777056
33MP0009785_altered_susceptibility_to1.23953768
34MP0005360_urolithiasis1.23865860
35MP0005253_abnormal_eye_physiology1.23646116
36MP0006072_abnormal_retinal_apoptosis1.20743951
37MP0010386_abnormal_urinary_bladder1.20192204
38MP0002693_abnormal_pancreas_physiology1.15790462
39MP0002909_abnormal_adrenal_gland1.14357857
40MP0005000_abnormal_immune_tolerance1.14233095
41MP0005408_hypopigmentation1.12922543
42MP0004134_abnormal_chest_morphology1.11311124
43MP0002638_abnormal_pupillary_reflex1.10827263
44MP0002138_abnormal_hepatobiliary_system1.10462479
45MP0003880_abnormal_central_pattern1.09676170
46MP0001968_abnormal_touch/_nociception1.08994654
47MP0004019_abnormal_vitamin_homeostasis1.07208002
48MP0002736_abnormal_nociception_after1.03213107
49MP0010234_abnormal_vibrissa_follicle1.02639322
50MP0001873_stomach_inflammation1.01434351
51MP0010678_abnormal_skin_adnexa1.01321187
52MP0005551_abnormal_eye_electrophysiolog1.00733903
53MP0003786_premature_aging1.00381494
54MP0001666_abnormal_nutrient_absorption0.99784730
55MP0001944_abnormal_pancreas_morphology0.99091231
56MP0002420_abnormal_adaptive_immunity0.96757184
57MP0006036_abnormal_mitochondrial_physio0.96392772
58MP0002006_tumorigenesis0.96375925
59MP0005310_abnormal_salivary_gland0.96182251
60MP0000371_diluted_coat_color0.94699878
61MP0003011_delayed_dark_adaptation0.93493296
62MP0002876_abnormal_thyroid_physiology0.93489660
63MP0001919_abnormal_reproductive_system0.92180066
64MP0001819_abnormal_immune_cell0.91732860
65MP0002723_abnormal_immune_serum0.91603232
66MP0001756_abnormal_urination0.90825969
67MP0000383_abnormal_hair_follicle0.90689595
68MP0005423_abnormal_somatic_nervous0.90036242
69MP0003866_abnormal_defecation0.84746563
70MP0002102_abnormal_ear_morphology0.83428670
71MP0003868_abnormal_feces_composition0.83084502
72MP0003718_maternal_effect0.81447966
73MP0003567_abnormal_fetal_cardiomyocyte0.80735548
74MP0001905_abnormal_dopamine_level0.78629408
75MP0002398_abnormal_bone_marrow0.78495911
76MP0002405_respiratory_system_inflammati0.78406995
77MP0008007_abnormal_cellular_replicative0.78357344
78MP0009333_abnormal_splenocyte_physiolog0.77746707
79MP0002928_abnormal_bile_duct0.77658878
80MP0003943_abnormal_hepatobiliary_system0.77546341
81MP0000716_abnormal_immune_system0.75384190
82MP0003950_abnormal_plasma_membrane0.74037050
83MP0004043_abnormal_pH_regulation0.73047644
84MP0004142_abnormal_muscle_tone0.72427957
85MP0000689_abnormal_spleen_morphology0.71771971
86MP0003252_abnormal_bile_duct0.70104140
87MP0001800_abnormal_humoral_immune0.69851669
88MP0009643_abnormal_urine_homeostasis0.69614895
89MP0008872_abnormal_physiological_respon0.69505689
90MP0000427_abnormal_hair_cycle0.68946708
91MP0001790_abnormal_immune_system0.66270501
92MP0005387_immune_system_phenotype0.66270501
93MP0000613_abnormal_salivary_gland0.63601427
94MP0005025_abnormal_response_to0.62969138
95MP0008469_abnormal_protein_level0.62464619
96MP0005266_abnormal_metabolism0.62460482
97MP0004215_abnormal_myocardial_fiber0.62131109
98MP0010155_abnormal_intestine_physiology0.61455910
99MP0001845_abnormal_inflammatory_respons0.61170828
100MP0005075_abnormal_melanosome_morpholog0.60473103

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.84504133
2Aplastic anemia (HP:0001915)4.67800557
3Abnormality of T cell number (HP:0011839)4.47897991
4Autoimmune hemolytic anemia (HP:0001890)4.27402285
5Autoimmune thrombocytopenia (HP:0001973)3.65874247
6Ketoacidosis (HP:0001993)3.56623655
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43556565
8Hypoproteinemia (HP:0003075)3.36039167
9Abnormality of T cells (HP:0002843)3.32994510
10Cutaneous melanoma (HP:0012056)2.99930192
11Oral leukoplakia (HP:0002745)2.99789628
12Renal cortical cysts (HP:0000803)2.96068895
13Intestinal atresia (HP:0011100)2.88756722
14Thyroiditis (HP:0100646)2.87924383
15Hepatocellular necrosis (HP:0001404)2.86672738
16Chronic diarrhea (HP:0002028)2.79025395
17Mitochondrial inheritance (HP:0001427)2.70921051
18Large for gestational age (HP:0001520)2.68015133
19Anhidrosis (HP:0000970)2.66593942
20Acute necrotizing encephalopathy (HP:0006965)2.65662934
21Progressive macrocephaly (HP:0004481)2.65165536
223-Methylglutaconic aciduria (HP:0003535)2.64572200
23Congenital, generalized hypertrichosis (HP:0004540)2.62583779
24Absent eyebrow (HP:0002223)2.59975450
25J-shaped sella turcica (HP:0002680)2.56251332
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.51086255
27Increased CSF lactate (HP:0002490)2.49170266
28Short chin (HP:0000331)2.42814409
29Hepatic necrosis (HP:0002605)2.42039413
30Severe combined immunodeficiency (HP:0004430)2.41872736
31Abnormality of the renal cortex (HP:0011035)2.39894609
32Abnormal mitochondria in muscle tissue (HP:0008316)2.39355752
33Palpitations (HP:0001962)2.36927747
34Concave nail (HP:0001598)2.36570726
35Pancreatic islet-cell hyperplasia (HP:0004510)2.31087790
36Neoplasm of the tracheobronchial system (HP:0100552)2.30024803
37Short hallux (HP:0010109)2.27563297
38IgG deficiency (HP:0004315)2.27407583
39Abnormality of the pancreatic islet cells (HP:0006476)2.23592337
40Abnormality of endocrine pancreas physiology (HP:0012093)2.23592337
41Hypoplastic ischia (HP:0003175)2.19053326
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17915620
43B lymphocytopenia (HP:0010976)2.16432627
44Hypomagnesemia (HP:0002917)2.15287275
45Recurrent viral infections (HP:0004429)2.14779755
46Abnormality of T cell physiology (HP:0011840)2.13097770
47Arthropathy (HP:0003040)2.12631534
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11883034
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11883034
50Combined immunodeficiency (HP:0005387)2.10042264
51Delayed CNS myelination (HP:0002188)2.06420780
52Abnormal albumin level (HP:0012116)2.03948023
53Hypoalbuminemia (HP:0003073)2.03948023
54Chronic mucocutaneous candidiasis (HP:0002728)2.03104025
55Recurrent cutaneous fungal infections (HP:0011370)2.03104025
56Abnormality of B cell number (HP:0010975)2.03080094
57Pancreatic cysts (HP:0001737)2.01845952
58Hypoglycemic seizures (HP:0002173)2.01782870
59Tetraparesis (HP:0002273)1.99356345
60Visual hallucinations (HP:0002367)1.98226876
61Prominent supraorbital ridges (HP:0000336)1.97096338
62Joint swelling (HP:0001386)1.96604743
63Acute encephalopathy (HP:0006846)1.96403895
64Aplasia/Hypoplasia of the hallux (HP:0008362)1.95898000
65Fair hair (HP:0002286)1.93923775
66Abolished electroretinogram (ERG) (HP:0000550)1.89082048
67Hyperinsulinemic hypoglycemia (HP:0000825)1.89028788
68Methylmalonic acidemia (HP:0002912)1.88848303
69Palpebral edema (HP:0100540)1.86834182
70Abnormal hair whorl (HP:0010721)1.86677342
71Conical tooth (HP:0000698)1.84972889
72Abnormality of eosinophils (HP:0001879)1.82891168
73Vascular calcification (HP:0004934)1.82846383
74True hermaphroditism (HP:0010459)1.82845853
75Methylmalonic aciduria (HP:0012120)1.82627326
76Abnormality of the ischium (HP:0003174)1.82067139
77Generalized hypopigmentation of hair (HP:0011358)1.81126226
78Type II lissencephaly (HP:0007260)1.80895984
79Squamous cell carcinoma (HP:0002860)1.79119673
80Abnormality of vitamin B metabolism (HP:0004340)1.78483426
81Volvulus (HP:0002580)1.78385754
82Hypoglycemic coma (HP:0001325)1.77455634
83Carpal bone hypoplasia (HP:0001498)1.77073388
84Progressive neurologic deterioration (HP:0002344)1.77017102
85Abnormal delayed hypersensitivity skin test (HP:0002963)1.75311297
86Increased cerebral lipofuscin (HP:0011813)1.74057058
87Long nose (HP:0003189)1.73562578
88Constricted visual fields (HP:0001133)1.72611336
89Mitral stenosis (HP:0001718)1.72322993
90Dysautonomia (HP:0002459)1.71831909
91Abnormality of alanine metabolism (HP:0010916)1.70769912
92Hyperalaninemia (HP:0003348)1.70769912
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70769912
94Testicular atrophy (HP:0000029)1.70667609
95Shoulder girdle muscle weakness (HP:0003547)1.70395603
96Type I diabetes mellitus (HP:0100651)1.69991696
97Respiratory failure (HP:0002878)1.69245880
98Respiratory difficulties (HP:0002880)1.68872282
99Lymphopenia (HP:0001888)1.68246715
100Pancytopenia (HP:0001876)1.68198118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.24523377
2FRK3.81858790
3TXK3.64660472
4TIE13.49627252
5EIF2AK12.60169281
6BMPR1B2.57450897
7STK162.43840495
8NEK12.36327178
9BUB12.13473007
10WNK32.13166144
11STK392.12042239
12PNCK2.11884391
13OXSR11.87997862
14NUAK11.84438201
15CAMKK21.80726106
16BRSK21.79148105
17AKT31.70171404
18KDR1.60003507
19MKNK11.52443119
20ADRBK21.51408296
21CASK1.47545221
22MAP4K11.44821671
23TAOK31.43750757
24DAPK21.43576220
25ITK1.42075501
26TEC1.40027425
27CCNB11.39970792
28GRK11.31184415
29MAP3K121.29165114
30BCKDK1.28500736
31WNK41.25951370
32MAP4K21.23207468
33TNIK1.21148865
34PDK21.18057622
35RAF11.13321743
36PRKCQ1.10050415
37ZAK1.09588614
38MAP3K141.06922357
39BRAF1.04854585
40MKNK21.01386818
41ERBB30.99234009
42FGFR10.97709107
43FES0.85870125
44BRSK10.80930878
45MAPKAPK30.79145463
46SRPK10.78514170
47MARK30.78300897
48ARAF0.77632134
49CDK30.77434913
50ILK0.74687752
51BMPR20.71769888
52PLK30.70578363
53PLK20.70316484
54CAMK2D0.68048122
55TSSK60.67849451
56ACVR1B0.66262968
57TRIM280.65371905
58EIF2AK20.62347534
59KSR10.62139065
60WNK10.62115917
61FGFR20.61998429
62FLT30.60744212
63PAK30.60119729
64FGR0.59902041
65PRKCI0.59632512
66MATK0.58650884
67CHEK20.58627206
68MYLK0.57736400
69INSRR0.56427924
70PRKCE0.55342876
71LCK0.53597382
72PRKACB0.52480320
73STK110.52442336
74TAOK20.52022977
75DMPK0.48493668
76PINK10.46355153
77IKBKB0.44728450
78TRPM70.44156898
79DAPK10.43273043
80CAMK2A0.43143481
81IGF1R0.40666864
82PRKCA0.39465261
83PHKG20.38987243
84PHKG10.38987243
85TTK0.38406284
86CDC70.37246536
87PRKACA0.36708867
88PIM20.36518988
89PRKG10.36214091
90MAP3K110.35563586
91OBSCN0.34184314
92TNK20.33223998
93PRKCG0.32982574
94LYN0.32623528
95MAP2K60.32619036
96MAPK130.31740531
97ROCK10.31107142
98PLK10.30348431
99RPS6KA50.29308763
100IRAK40.28725016

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.11315118
2Protein export_Homo sapiens_hsa030604.73063217
3Proteasome_Homo sapiens_hsa030503.55013348
4Butanoate metabolism_Homo sapiens_hsa006502.66249737
5Primary immunodeficiency_Homo sapiens_hsa053402.51113942
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.40174030
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32902238
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.31083581
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18333869
10Folate biosynthesis_Homo sapiens_hsa007902.02382768
11Non-homologous end-joining_Homo sapiens_hsa034501.98576245
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.94803999
13Oxidative phosphorylation_Homo sapiens_hsa001901.94135314
14Nitrogen metabolism_Homo sapiens_hsa009101.76927744
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73065044
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70269106
17Homologous recombination_Homo sapiens_hsa034401.67395022
18Parkinsons disease_Homo sapiens_hsa050121.66191444
19RNA degradation_Homo sapiens_hsa030181.63873676
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58190778
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56671807
22Type I diabetes mellitus_Homo sapiens_hsa049401.44433645
23Hematopoietic cell lineage_Homo sapiens_hsa046401.42438634
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41224296
25Propanoate metabolism_Homo sapiens_hsa006401.36406720
26Ether lipid metabolism_Homo sapiens_hsa005651.36331161
27Antigen processing and presentation_Homo sapiens_hsa046121.33051894
28Measles_Homo sapiens_hsa051621.30506622
29RNA polymerase_Homo sapiens_hsa030201.30382878
30Peroxisome_Homo sapiens_hsa041461.23888398
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23708846
32Rheumatoid arthritis_Homo sapiens_hsa053231.23302944
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22307930
34Regulation of autophagy_Homo sapiens_hsa041401.19566900
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18204124
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17538425
37Linoleic acid metabolism_Homo sapiens_hsa005911.15114571
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14408611
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12217778
40Fanconi anemia pathway_Homo sapiens_hsa034601.03655103
41T cell receptor signaling pathway_Homo sapiens_hsa046601.02805030
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00480024
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00356243
44Fatty acid metabolism_Homo sapiens_hsa012120.96554383
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91563540
46Allograft rejection_Homo sapiens_hsa053300.88414904
47Mineral absorption_Homo sapiens_hsa049780.88225965
48Autoimmune thyroid disease_Homo sapiens_hsa053200.87904712
49Collecting duct acid secretion_Homo sapiens_hsa049660.84761473
50Alzheimers disease_Homo sapiens_hsa050100.84324038
51Graft-versus-host disease_Homo sapiens_hsa053320.84300687
52Fatty acid degradation_Homo sapiens_hsa000710.80720106
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79984689
54Phototransduction_Homo sapiens_hsa047440.76997809
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.75585181
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72269417
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68626193
58Steroid biosynthesis_Homo sapiens_hsa001000.62821071
59RNA transport_Homo sapiens_hsa030130.62599973
60Basal transcription factors_Homo sapiens_hsa030220.62094391
61Huntingtons disease_Homo sapiens_hsa050160.61562212
62Insulin secretion_Homo sapiens_hsa049110.61416733
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61372410
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60499739
65Pyrimidine metabolism_Homo sapiens_hsa002400.60042271
66ABC transporters_Homo sapiens_hsa020100.58392299
67Caffeine metabolism_Homo sapiens_hsa002320.57160689
68Spliceosome_Homo sapiens_hsa030400.53968222
69Purine metabolism_Homo sapiens_hsa002300.52042323
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51816049
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50512126
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50340896
73One carbon pool by folate_Homo sapiens_hsa006700.49074790
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.47429309
75Arachidonic acid metabolism_Homo sapiens_hsa005900.44473149
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40920985
77Serotonergic synapse_Homo sapiens_hsa047260.40865674
78Metabolic pathways_Homo sapiens_hsa011000.40455120
79Pancreatic secretion_Homo sapiens_hsa049720.39009200
80Cardiac muscle contraction_Homo sapiens_hsa042600.33992730
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33478542
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33128361
83Nucleotide excision repair_Homo sapiens_hsa034200.32826176
84Herpes simplex infection_Homo sapiens_hsa051680.32487996
85Dorso-ventral axis formation_Homo sapiens_hsa043200.31830786
86Fat digestion and absorption_Homo sapiens_hsa049750.31312535
87Tryptophan metabolism_Homo sapiens_hsa003800.31294533
88Mismatch repair_Homo sapiens_hsa034300.29696011
89Retinol metabolism_Homo sapiens_hsa008300.27771156
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.23818719
91African trypanosomiasis_Homo sapiens_hsa051430.23465965
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23208680
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.23180545
94Fatty acid elongation_Homo sapiens_hsa000620.22469034
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22329877
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21597781
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20468567
98Morphine addiction_Homo sapiens_hsa050320.19597682
99Chemokine signaling pathway_Homo sapiens_hsa040620.18880216
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18087344

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