RPL7P58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.72813876
2DNA deamination (GO:0045006)5.31959570
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54130366
4ATP synthesis coupled proton transport (GO:0015986)4.54130366
5viral transcription (GO:0019083)4.36538913
6translational termination (GO:0006415)4.17263172
7maturation of SSU-rRNA (GO:0030490)4.08201604
8behavioral response to nicotine (GO:0035095)4.04872496
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95638252
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95279554
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95279554
12L-fucose catabolic process (GO:0042355)3.80194234
13fucose catabolic process (GO:0019317)3.80194234
14L-fucose metabolic process (GO:0042354)3.80194234
15translational elongation (GO:0006414)3.77504583
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74115707
17cotranslational protein targeting to membrane (GO:0006613)3.68125875
18protein complex biogenesis (GO:0070271)3.68076240
19protein targeting to ER (GO:0045047)3.66660931
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.63757976
21NADH dehydrogenase complex assembly (GO:0010257)3.63757976
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63757976
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61444343
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59743824
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58159917
26GTP biosynthetic process (GO:0006183)3.57046930
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52213214
28protein localization to endoplasmic reticulum (GO:0070972)3.50724874
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.47660484
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47546442
31water-soluble vitamin biosynthetic process (GO:0042364)3.46153789
32chaperone-mediated protein transport (GO:0072321)3.41154317
33protein neddylation (GO:0045116)3.39959012
34ribosomal large subunit biogenesis (GO:0042273)3.39349541
35regulation of immunoglobulin secretion (GO:0051023)3.36971474
36piRNA metabolic process (GO:0034587)3.35332495
37ribosomal small subunit biogenesis (GO:0042274)3.32861000
38rRNA modification (GO:0000154)3.27533610
39mitochondrial respiratory chain complex assembly (GO:0033108)3.27165382
40viral life cycle (GO:0019058)3.25885900
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25708894
42response to pheromone (GO:0019236)3.23490920
43electron transport chain (GO:0022900)3.22374712
44preassembly of GPI anchor in ER membrane (GO:0016254)3.20223939
45negative regulation of B cell apoptotic process (GO:0002903)3.20089172
46respiratory electron transport chain (GO:0022904)3.19102913
47maturation of 5.8S rRNA (GO:0000460)3.17723843
48kynurenine metabolic process (GO:0070189)3.16473428
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.15609494
50regulation of isotype switching to IgG isotypes (GO:0048302)3.14848435
51protein polyglutamylation (GO:0018095)3.11588859
52indole-containing compound catabolic process (GO:0042436)3.08830964
53indolalkylamine catabolic process (GO:0046218)3.08830964
54tryptophan catabolic process (GO:0006569)3.08830964
55translation (GO:0006412)3.08702464
56translational initiation (GO:0006413)3.06201308
57base-excision repair, AP site formation (GO:0006285)3.02204359
58UTP biosynthetic process (GO:0006228)3.02123190
59cellular response to interferon-beta (GO:0035458)3.01049622
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.99032050
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98278399
62cellular protein complex disassembly (GO:0043624)2.96596682
63UTP metabolic process (GO:0046051)2.94262429
64positive regulation of prostaglandin secretion (GO:0032308)2.93142413
65tRNA processing (GO:0008033)2.91540693
66respiratory chain complex IV assembly (GO:0008535)2.88257663
67proteasome assembly (GO:0043248)2.88219837
68tryptophan metabolic process (GO:0006568)2.87476120
69amine catabolic process (GO:0009310)2.81954226
70cellular biogenic amine catabolic process (GO:0042402)2.81954226
71positive regulation of fatty acid transport (GO:2000193)2.80182284
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.79357226
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78996573
74regulation of mitotic spindle checkpoint (GO:1903504)2.78996573
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78463195
76isotype switching (GO:0045190)2.78463195
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78463195
78RNA phosphodiester bond hydrolysis (GO:0090501)2.78226795
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.76795811
80termination of RNA polymerase III transcription (GO:0006386)2.76795811
81hydrogen ion transmembrane transport (GO:1902600)2.76499892
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76014044
83indolalkylamine metabolic process (GO:0006586)2.75146005
84negative regulation of telomere maintenance (GO:0032205)2.74836663
85cellular component biogenesis (GO:0044085)2.74685628
86proton transport (GO:0015992)2.74666215
87cellular response to exogenous dsRNA (GO:0071360)2.74255686
88rRNA metabolic process (GO:0016072)2.73405355
89GPI anchor metabolic process (GO:0006505)2.73261301
90rRNA processing (GO:0006364)2.72867892
91rRNA catabolic process (GO:0016075)2.72556346
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72170569
93cytochrome complex assembly (GO:0017004)2.72032145
94regulation of B cell apoptotic process (GO:0002902)2.71592622
95hydrogen transport (GO:0006818)2.71263131
96regulation of regulatory T cell differentiation (GO:0045589)2.69621525
97pseudouridine synthesis (GO:0001522)2.68968840
98mannosylation (GO:0097502)2.61633051
99protein-cofactor linkage (GO:0018065)2.60175903
100intracellular protein transmembrane import (GO:0044743)2.59472128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.19792735
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79043481
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.32596642
4VDR_22108803_ChIP-Seq_LS180_Human3.13588790
5EZH2_22144423_ChIP-Seq_EOC_Human3.11736232
6ZNF274_21170338_ChIP-Seq_K562_Hela3.10750885
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00852086
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70862941
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62422882
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.53925443
11VDR_23849224_ChIP-Seq_CD4+_Human2.43429689
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37078023
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24910972
14ELK1_19687146_ChIP-ChIP_HELA_Human2.05009793
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.02359745
16FOXP3_21729870_ChIP-Seq_TREG_Human1.88873284
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88867985
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.86694886
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81963386
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.81922085
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79069232
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75418964
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71314246
24EWS_26573619_Chip-Seq_HEK293_Human1.71154557
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.70067594
26MYC_18940864_ChIP-ChIP_HL60_Human1.69145277
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66899133
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66763106
29TP53_22573176_ChIP-Seq_HFKS_Human1.64983968
30FUS_26573619_Chip-Seq_HEK293_Human1.60054781
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56285026
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46359051
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45056912
34IGF1R_20145208_ChIP-Seq_DFB_Human1.44146349
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41509565
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41147717
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40068015
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.39968256
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39968256
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.39592323
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.38715606
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37919012
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33377966
44IRF1_19129219_ChIP-ChIP_H3396_Human1.32920669
45ER_23166858_ChIP-Seq_MCF-7_Human1.32014752
46TAF15_26573619_Chip-Seq_HEK293_Human1.30372935
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28897823
48TTF2_22483619_ChIP-Seq_HELA_Human1.28358160
49AR_20517297_ChIP-Seq_VCAP_Human1.26789942
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26595696
51GATA3_26560356_Chip-Seq_TH2_Human1.24396971
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24209951
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23987238
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22848276
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.22779488
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.21949783
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20436237
58TAF2_19829295_ChIP-Seq_ESCs_Human1.19835630
59NCOR_22424771_ChIP-Seq_293T_Human1.19319499
60NANOG_19829295_ChIP-Seq_ESCs_Human1.18658021
61SOX2_19829295_ChIP-Seq_ESCs_Human1.18658021
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17978240
63NANOG_20526341_ChIP-Seq_ESCs_Human1.16977092
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16368441
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15125217
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14977762
67ERA_21632823_ChIP-Seq_H3396_Human1.14666793
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14597530
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.12106772
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11679812
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11512967
72P300_19829295_ChIP-Seq_ESCs_Human1.10737201
73STAT1_20625510_ChIP-Seq_HELA_Human1.08117427
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.07430057
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06525253
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06010353
77MYC_19829295_ChIP-Seq_ESCs_Human1.05818503
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05284489
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05070341
80P53_21459846_ChIP-Seq_SAOS-2_Human1.04408379
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02533625
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02175395
83GBX2_23144817_ChIP-Seq_PC3_Human1.01273649
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99953155
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99173785
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98588391
87HOXB7_26014856_ChIP-Seq_BT474_Human0.97703572
88CBP_20019798_ChIP-Seq_JUKART_Human0.95809279
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95809279
90BCAT_22108803_ChIP-Seq_LS180_Human0.95723896
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93749517
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93366656
93GABP_19822575_ChIP-Seq_HepG2_Human0.93182015
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93161952
95TCF4_22108803_ChIP-Seq_LS180_Human0.92947655
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.92945749
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92414492
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92123720
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.92043502
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88037981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.00173010
2MP0009379_abnormal_foot_pigmentation3.19449230
3MP0002138_abnormal_hepatobiliary_system3.14965374
4MP0008877_abnormal_DNA_methylation2.96531151
5MP0003646_muscle_fatigue2.79386617
6MP0005646_abnormal_pituitary_gland2.51773621
7MP0003787_abnormal_imprinting2.51510207
8MP0002102_abnormal_ear_morphology2.41868293
9MP0008872_abnormal_physiological_respon2.38339006
10MP0001835_abnormal_antigen_presentation2.36535142
11MP0001968_abnormal_touch/_nociception2.19557523
12MP0002837_dystrophic_cardiac_calcinosis2.14468848
13MP0008875_abnormal_xenobiotic_pharmacok2.10179488
14MP0004147_increased_porphyrin_level2.09863319
15MP0003011_delayed_dark_adaptation2.00826293
16MP0005084_abnormal_gallbladder_morpholo1.94468495
17MP0006072_abnormal_retinal_apoptosis1.87515768
18MP0004142_abnormal_muscle_tone1.82873825
19MP0004885_abnormal_endolymph1.80246758
20MP0005551_abnormal_eye_electrophysiolog1.75879209
21MP0002736_abnormal_nociception_after1.73693263
22MP0002234_abnormal_pharynx_morphology1.68119846
23MP0003786_premature_aging1.63651428
24MP0001986_abnormal_taste_sensitivity1.56716877
25MP0008789_abnormal_olfactory_epithelium1.55912144
26MP0003806_abnormal_nucleotide_metabolis1.52458220
27MP0002148_abnormal_hypersensitivity_rea1.50776731
28MP0008995_early_reproductive_senescence1.50025251
29MP0001905_abnormal_dopamine_level1.49269855
30MP0005075_abnormal_melanosome_morpholog1.49038531
31MP0006036_abnormal_mitochondrial_physio1.46536328
32MP0000372_irregular_coat_pigmentation1.46159170
33MP0005645_abnormal_hypothalamus_physiol1.44206910
34MP0002272_abnormal_nervous_system1.40744407
35MP0008775_abnormal_heart_ventricle1.39856432
36MP0002163_abnormal_gland_morphology1.39678307
37MP0006276_abnormal_autonomic_nervous1.38405234
38MP0005389_reproductive_system_phenotype1.37300831
39MP0002876_abnormal_thyroid_physiology1.36869492
40MP0002733_abnormal_thermal_nociception1.36377103
41MP0005671_abnormal_response_to1.35854451
42MP0003121_genomic_imprinting1.35837600
43MP0002160_abnormal_reproductive_system1.31925840
44MP0000427_abnormal_hair_cycle1.31481722
45MP0003718_maternal_effect1.30240605
46MP0003122_maternal_imprinting1.23793223
47MP0003195_calcinosis1.22949945
48MP0001293_anophthalmia1.21218856
49MP0003252_abnormal_bile_duct1.20679326
50MP0008058_abnormal_DNA_repair1.18917585
51MP0001970_abnormal_pain_threshold1.12240413
52MP0005253_abnormal_eye_physiology1.11766080
53MP0001984_abnormal_olfaction1.11071825
54MP0001919_abnormal_reproductive_system1.10914937
55MP0001485_abnormal_pinna_reflex1.08941151
56MP0001440_abnormal_grooming_behavior1.07626644
57MP0009745_abnormal_behavioral_response1.06506900
58MP0001800_abnormal_humoral_immune1.03603227
59MP0003878_abnormal_ear_physiology0.99948939
60MP0005377_hearing/vestibular/ear_phenot0.99948939
61MP0009046_muscle_twitch0.99394789
62MP0002638_abnormal_pupillary_reflex0.99148939
63MP0005085_abnormal_gallbladder_physiolo0.97904715
64MP0001853_heart_inflammation0.97833578
65MP0009764_decreased_sensitivity_to0.97042985
66MP0001790_abnormal_immune_system0.96465960
67MP0005387_immune_system_phenotype0.96465960
68MP0005167_abnormal_blood-brain_barrier0.96096315
69MP0004145_abnormal_muscle_electrophysio0.96026792
70MP0000230_abnormal_systemic_arterial0.95885534
71MP0005379_endocrine/exocrine_gland_phen0.94477262
72MP0005499_abnormal_olfactory_system0.89567795
73MP0005394_taste/olfaction_phenotype0.89567795
74MP0000613_abnormal_salivary_gland0.88705332
75MP0000631_abnormal_neuroendocrine_gland0.86318913
76MP0002572_abnormal_emotion/affect_behav0.85743139
77MP0001501_abnormal_sleep_pattern0.83506850
78MP0000685_abnormal_immune_system0.83423264
79MP0005410_abnormal_fertilization0.81663417
80MP0002735_abnormal_chemical_nociception0.81499467
81MP0010386_abnormal_urinary_bladder0.81206275
82MP0002557_abnormal_social/conspecific_i0.80093700
83MP0002095_abnormal_skin_pigmentation0.79984146
84MP0005000_abnormal_immune_tolerance0.79069427
85MP0001873_stomach_inflammation0.76497907
86MP0005636_abnormal_mineral_homeostasis0.73979217
87MP0003638_abnormal_response/metabolism_0.73744132
88MP0005195_abnormal_posterior_eye0.73101651
89MP0002723_abnormal_immune_serum0.72419448
90MP0004742_abnormal_vestibular_system0.72368657
91MP0003186_abnormal_redox_activity0.72043688
92MP0001765_abnormal_ion_homeostasis0.70580620
93MP0004043_abnormal_pH_regulation0.70389914
94MP0000604_amyloidosis0.69837899
95MP0005332_abnormal_amino_acid0.69816492
96MP0004019_abnormal_vitamin_homeostasis0.69662394
97MP0002210_abnormal_sex_determination0.69547568
98MP0002282_abnormal_trachea_morphology0.68774688
99MP0006035_abnormal_mitochondrial_morpho0.67671963
100MP0000049_abnormal_middle_ear0.67225537

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32266988
2Abnormality of midbrain morphology (HP:0002418)4.05173760
3Molar tooth sign on MRI (HP:0002419)4.05173760
4Acute encephalopathy (HP:0006846)3.99439959
5Congenital stationary night blindness (HP:0007642)3.87420210
6Pancreatic cysts (HP:0001737)3.82812022
7Abnormal mitochondria in muscle tissue (HP:0008316)3.69718191
8Progressive macrocephaly (HP:0004481)3.68816224
9Mitochondrial inheritance (HP:0001427)3.61933492
10Pancreatic fibrosis (HP:0100732)3.61546818
11Reticulocytopenia (HP:0001896)3.41675296
12Increased CSF lactate (HP:0002490)3.40450287
13Nephronophthisis (HP:0000090)3.29051558
14Hepatocellular necrosis (HP:0001404)3.11475517
15Elevated erythrocyte sedimentation rate (HP:0003565)3.06489095
163-Methylglutaconic aciduria (HP:0003535)3.02030027
17Stomatitis (HP:0010280)2.98497540
18True hermaphroditism (HP:0010459)2.97151947
19Hepatic necrosis (HP:0002605)2.92678490
20Abnormality of the renal cortex (HP:0011035)2.91479953
21Abnormality of the renal medulla (HP:0100957)2.83559452
22Aplasia/Hypoplasia of the spleen (HP:0010451)2.80221858
23Abolished electroretinogram (ERG) (HP:0000550)2.77104072
24Abnormality of cells of the erythroid lineage (HP:0012130)2.76415052
25Asplenia (HP:0001746)2.75476167
26Congenital, generalized hypertrichosis (HP:0004540)2.74862940
27Bile duct proliferation (HP:0001408)2.72416063
28Abnormal biliary tract physiology (HP:0012439)2.72416063
29Absent/shortened dynein arms (HP:0200106)2.72222846
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.72222846
31Optic disc pallor (HP:0000543)2.72039768
32Medial flaring of the eyebrow (HP:0010747)2.68225574
33Cerebral edema (HP:0002181)2.67539631
34Abnormal rod and cone electroretinograms (HP:0008323)2.64248294
35Polydipsia (HP:0001959)2.58791534
36Abnormal drinking behavior (HP:0030082)2.58791534
37Renal cortical cysts (HP:0000803)2.53766675
38Absent thumb (HP:0009777)2.53598055
39Abnormality of the prostate (HP:0008775)2.53240618
40Cystic liver disease (HP:0006706)2.52137085
41Type II lissencephaly (HP:0007260)2.48355900
42IgG deficiency (HP:0004315)2.45654412
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44268133
44Increased serum lactate (HP:0002151)2.39689948
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37513558
46Abnormal respiratory motile cilium morphology (HP:0005938)2.36305791
47Abnormal respiratory epithelium morphology (HP:0012253)2.36305791
48Prostate neoplasm (HP:0100787)2.35643647
49Attenuation of retinal blood vessels (HP:0007843)2.28414061
50Colon cancer (HP:0003003)2.25882946
51Lactic acidosis (HP:0003128)2.24811586
52Abnormal number of erythroid precursors (HP:0012131)2.24734590
53Hyperglycinemia (HP:0002154)2.16409407
54Sclerocornea (HP:0000647)2.15592656
55Pendular nystagmus (HP:0012043)2.14649137
56Hypomagnesemia (HP:0002917)2.12924371
57Polyuria (HP:0000103)2.11618749
58Increased hepatocellular lipid droplets (HP:0006565)2.11209861
59Methylmalonic acidemia (HP:0002912)2.09378824
60Macrocytic anemia (HP:0001972)2.06814399
61Lipid accumulation in hepatocytes (HP:0006561)2.05781086
62Congenital hepatic fibrosis (HP:0002612)2.05222010
63Panhypogammaglobulinemia (HP:0003139)2.04778659
64Tubular atrophy (HP:0000092)2.01749964
65Chronic hepatic failure (HP:0100626)1.99463997
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96016727
67Type 2 muscle fiber atrophy (HP:0003554)1.95520621
68Renal Fanconi syndrome (HP:0001994)1.95473877
69Abnormal ciliary motility (HP:0012262)1.95335235
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95250219
71Lethargy (HP:0001254)1.93451517
72Delayed CNS myelination (HP:0002188)1.92635165
73Anencephaly (HP:0002323)1.91618647
74Abnormality of the labia minora (HP:0012880)1.89248592
75Abnormality of alanine metabolism (HP:0010916)1.87352974
76Hyperalaninemia (HP:0003348)1.87352974
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87352974
78Progressive microcephaly (HP:0000253)1.86605874
79Male pseudohermaphroditism (HP:0000037)1.86545645
80Keratoconus (HP:0000563)1.86366229
81Increased corneal curvature (HP:0100692)1.86366229
82Supernumerary spleens (HP:0009799)1.86225126
83Leukodystrophy (HP:0002415)1.83739701
84Respiratory failure (HP:0002878)1.82104642
85Methylmalonic aciduria (HP:0012120)1.80562408
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78058413
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78058413
88Postaxial foot polydactyly (HP:0001830)1.75843489
89Abnormality of magnesium homeostasis (HP:0004921)1.74012981
90Adactyly (HP:0009776)1.73992256
91Agitation (HP:0000713)1.73835001
92Abnormality of the proximal phalanges of the hand (HP:0009834)1.73439463
93Gait imbalance (HP:0002141)1.72411349
94Exercise intolerance (HP:0003546)1.72406350
95Constricted visual fields (HP:0001133)1.72074843
96Agammaglobulinemia (HP:0004432)1.72020388
97Chronic sinusitis (HP:0011109)1.70943403
98Decreased central vision (HP:0007663)1.70374296
99Congenital primary aphakia (HP:0007707)1.69628296
100Abnormal urine output (HP:0012590)1.68872202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.42654211
2NUAK13.27593490
3GRK12.99739469
4STK162.93970971
5ZAK2.77728564
6FRK2.74450519
7ADRBK22.36058467
8PINK12.34000617
9MAP4K22.27472305
10TAOK32.19072690
11VRK22.12629514
12BMPR1B2.09865525
13CDK191.97582271
14WNK41.97060417
15TIE11.73046689
16ACVR1B1.72333745
17TXK1.66774366
18PHKG21.60063096
19PHKG11.60063096
20TEC1.55412438
21MAPKAPK31.51085886
22OXSR11.47603285
23DYRK21.43046235
24BCKDK1.37516423
25MAP4K11.37108562
26KIT1.34676496
27PIK3CA1.34245913
28CAMKK21.32144936
29CSNK1G21.29624393
30EIF2AK11.28755608
31ITK1.25624381
32CSNK1G31.22915507
33EIF2AK31.10291133
34MAPKAPK51.08666369
35WNK31.06239228
36MKNK11.05526059
37NEK11.01214375
38FES1.00252732
39STK391.00063364
40CSNK1A1L0.98905125
41SYK0.96810140
42INSRR0.96789613
43MAP2K60.95920056
44VRK10.94822251
45PIK3CG0.94789199
46CSNK1G10.90945928
47PRKCQ0.86524460
48NME20.86095035
49IKBKB0.85871344
50RPS6KA50.81580044
51TSSK60.79355382
52ADRBK10.77930906
53SRPK10.76927889
54TRIM280.75469624
55DAPK10.74330604
56DAPK20.74308484
57MAPK130.74307177
58MST40.73915232
59TAF10.71003550
60PLK20.69688763
61MUSK0.69301143
62BTK0.69216170
63BUB10.68373691
64PRKCG0.66326668
65TESK20.66012167
66LYN0.65935400
67IKBKE0.65583721
68CAMK10.61964389
69DAPK30.61534283
70RPS6KB20.59236477
71PLK40.57677901
72PLK30.57165234
73EIF2AK20.56026128
74MAP3K120.55979314
75PRKCI0.54821711
76GRK50.52946949
77CAMKK10.51366249
78PRKCE0.51073641
79JAK30.46779891
80PRKACA0.46140617
81MAP3K140.44416605
82PBK0.43831780
83LCK0.43830016
84IGF1R0.43279564
85PAK30.43187918
86MKNK20.42937526
87NME10.42881941
88MAP3K40.42856687
89RIPK40.42417425
90PRKCA0.41908325
91MAP3K110.41588942
92MYLK0.40176915
93CSNK2A20.39889735
94OBSCN0.39116146
95ATR0.39113216
96PASK0.38591695
97PLK10.38427943
98CSNK1A10.35637949
99TGFBR10.34148293
100CSNK2A10.33931284

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.89828628
2Ribosome_Homo sapiens_hsa030103.77044148
3Proteasome_Homo sapiens_hsa030503.05072738
4Oxidative phosphorylation_Homo sapiens_hsa001903.03848481
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.99589730
6Allograft rejection_Homo sapiens_hsa053302.99442592
7Autoimmune thyroid disease_Homo sapiens_hsa053202.83663775
8Parkinsons disease_Homo sapiens_hsa050122.53739082
9Graft-versus-host disease_Homo sapiens_hsa053322.34585227
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21932231
11RNA polymerase_Homo sapiens_hsa030202.20871753
12Type I diabetes mellitus_Homo sapiens_hsa049402.19203596
13Protein export_Homo sapiens_hsa030602.08266807
14Linoleic acid metabolism_Homo sapiens_hsa005912.06002268
15One carbon pool by folate_Homo sapiens_hsa006701.81552539
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81537346
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80752301
18Homologous recombination_Homo sapiens_hsa034401.80510546
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77962656
20RNA degradation_Homo sapiens_hsa030181.62425882
21Alzheimers disease_Homo sapiens_hsa050101.56918881
22Phototransduction_Homo sapiens_hsa047441.54215610
23Mismatch repair_Homo sapiens_hsa034301.52969459
24Huntingtons disease_Homo sapiens_hsa050161.47500109
25Fanconi anemia pathway_Homo sapiens_hsa034601.40496572
26Cardiac muscle contraction_Homo sapiens_hsa042601.36317511
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34355860
28Arachidonic acid metabolism_Homo sapiens_hsa005901.31852399
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31235308
30Primary immunodeficiency_Homo sapiens_hsa053401.29603871
31Sulfur metabolism_Homo sapiens_hsa009201.24054437
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22162283
33Nucleotide excision repair_Homo sapiens_hsa034201.21340680
34Propanoate metabolism_Homo sapiens_hsa006401.17898022
35Basal transcription factors_Homo sapiens_hsa030221.17207706
36Rheumatoid arthritis_Homo sapiens_hsa053231.17142124
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15538297
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14048559
39Tryptophan metabolism_Homo sapiens_hsa003801.13758957
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10790826
41Pyrimidine metabolism_Homo sapiens_hsa002401.08371134
42Antigen processing and presentation_Homo sapiens_hsa046121.05387553
43Peroxisome_Homo sapiens_hsa041461.03002020
44Ether lipid metabolism_Homo sapiens_hsa005651.01520172
45Base excision repair_Homo sapiens_hsa034101.01319619
46Nitrogen metabolism_Homo sapiens_hsa009100.99526901
47Caffeine metabolism_Homo sapiens_hsa002320.96825903
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93695529
49Purine metabolism_Homo sapiens_hsa002300.92254463
50DNA replication_Homo sapiens_hsa030300.91909538
51RNA transport_Homo sapiens_hsa030130.91416830
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87034572
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86392601
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86123473
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83740511
56Olfactory transduction_Homo sapiens_hsa047400.79691809
57Chemical carcinogenesis_Homo sapiens_hsa052040.78314874
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77362209
59Selenocompound metabolism_Homo sapiens_hsa004500.75809493
60Butanoate metabolism_Homo sapiens_hsa006500.74152958
61Ovarian steroidogenesis_Homo sapiens_hsa049130.73622267
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.73339559
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.69907024
64Viral myocarditis_Homo sapiens_hsa054160.69819235
65Retinol metabolism_Homo sapiens_hsa008300.68063088
66Hematopoietic cell lineage_Homo sapiens_hsa046400.67132467
67Fatty acid elongation_Homo sapiens_hsa000620.66644718
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63050871
69Fat digestion and absorption_Homo sapiens_hsa049750.60445816
70Metabolic pathways_Homo sapiens_hsa011000.60245468
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60009469
72Staphylococcus aureus infection_Homo sapiens_hsa051500.59862263
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59674500
74Systemic lupus erythematosus_Homo sapiens_hsa053220.59141468
75Collecting duct acid secretion_Homo sapiens_hsa049660.58563669
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58310205
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.56363338
78Spliceosome_Homo sapiens_hsa030400.53829667
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51686896
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.50909698
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49708292
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46433532
83Non-homologous end-joining_Homo sapiens_hsa034500.39994867
84Salivary secretion_Homo sapiens_hsa049700.39296134
85Pyruvate metabolism_Homo sapiens_hsa006200.38972098
86Nicotine addiction_Homo sapiens_hsa050330.37494666
87Taste transduction_Homo sapiens_hsa047420.36859204
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.36639540
89Sulfur relay system_Homo sapiens_hsa041220.34301669
90Morphine addiction_Homo sapiens_hsa050320.33150372
91Glutathione metabolism_Homo sapiens_hsa004800.32642608
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29492324
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28081413
94Serotonergic synapse_Homo sapiens_hsa047260.26794384
95Arginine and proline metabolism_Homo sapiens_hsa003300.24889998
96Glycerolipid metabolism_Homo sapiens_hsa005610.23901131
97Regulation of autophagy_Homo sapiens_hsa041400.23709876
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23128032
99Leishmaniasis_Homo sapiens_hsa051400.19723413
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.18520367

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