RPL7P59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.48425945
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40848165
3ATP synthesis coupled proton transport (GO:0015986)5.40848165
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06955939
5kynurenine metabolic process (GO:0070189)4.53627240
6indole-containing compound catabolic process (GO:0042436)4.07575171
7indolalkylamine catabolic process (GO:0046218)4.07575171
8tryptophan catabolic process (GO:0006569)4.07575171
9regulation of immunoglobulin secretion (GO:0051023)4.02080169
10piRNA metabolic process (GO:0034587)3.64021873
11positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.63492925
12tryptophan metabolic process (GO:0006568)3.61791925
13L-fucose catabolic process (GO:0042355)3.56946625
14fucose catabolic process (GO:0019317)3.56946625
15L-fucose metabolic process (GO:0042354)3.56946625
16proteasome assembly (GO:0043248)3.55429640
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49433963
18positive regulation of prostaglandin secretion (GO:0032308)3.47466618
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42133869
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.37177412
21water-soluble vitamin biosynthetic process (GO:0042364)3.36071634
22respiratory chain complex IV assembly (GO:0008535)3.30327032
23protein neddylation (GO:0045116)3.28317453
24behavioral response to nicotine (GO:0035095)3.25356956
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.24436011
26somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.20845638
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.20845638
28isotype switching (GO:0045190)3.20845638
29negative regulation of heart rate (GO:0010459)3.17777603
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17478962
31positive regulation of protein homodimerization activity (GO:0090073)3.17120321
32electron transport chain (GO:0022900)3.16101068
33respiratory electron transport chain (GO:0022904)3.16003100
34pseudouridine synthesis (GO:0001522)3.15130119
35positive regulation of defense response to virus by host (GO:0002230)3.09565190
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09473779
37indolalkylamine metabolic process (GO:0006586)3.09098448
38chaperone-mediated protein transport (GO:0072321)3.08724334
39rRNA modification (GO:0000154)3.07235373
40maturation of 5.8S rRNA (GO:0000460)3.06013346
41negative regulation of mast cell activation (GO:0033004)3.03128245
42platelet dense granule organization (GO:0060155)3.01509172
43cytochrome complex assembly (GO:0017004)3.00831578
44ATP biosynthetic process (GO:0006754)2.98608026
45protein complex biogenesis (GO:0070271)2.98412768
46DNA double-strand break processing (GO:0000729)2.96558345
47cellular response to exogenous dsRNA (GO:0071360)2.95302750
48preassembly of GPI anchor in ER membrane (GO:0016254)2.95135438
49ribosomal small subunit assembly (GO:0000028)2.92206945
50regulation of regulatory T cell differentiation (GO:0045589)2.90261501
51regulation of isotype switching to IgG isotypes (GO:0048302)2.89357194
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85149456
53purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84544401
54regulation of memory T cell differentiation (GO:0043380)2.84434037
55cytidine metabolic process (GO:0046087)2.82204369
56cytidine catabolic process (GO:0006216)2.82204369
57cytidine deamination (GO:0009972)2.82204369
58cellular biogenic amine catabolic process (GO:0042402)2.79356513
59amine catabolic process (GO:0009310)2.79356513
60regulation of cellular amino acid metabolic process (GO:0006521)2.78407200
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76189112
62mast cell activation (GO:0045576)2.76125678
63mitochondrial respiratory chain complex assembly (GO:0033108)2.73318759
64regulation of prostaglandin secretion (GO:0032306)2.71782188
65positive regulation of activated T cell proliferation (GO:0042104)2.70535200
66positive regulation of interleukin-17 production (GO:0032740)2.69981434
67hydrogen ion transmembrane transport (GO:1902600)2.69790338
68DNA methylation involved in gamete generation (GO:0043046)2.68858992
69immunoglobulin mediated immune response (GO:0016064)2.68777196
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67360835
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67360835
72ribosomal large subunit biogenesis (GO:0042273)2.65791675
73proton transport (GO:0015992)2.64562694
74negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62901122
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.61097272
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.60831402
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60584883
78hydrogen transport (GO:0006818)2.60362527
79positive regulation of DNA recombination (GO:0045911)2.60334590
80positive regulation of fatty acid transport (GO:2000193)2.59746206
81S-adenosylmethionine metabolic process (GO:0046500)2.59364534
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.58121679
83NADH dehydrogenase complex assembly (GO:0010257)2.58121679
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58121679
85response to interferon-beta (GO:0035456)2.55876200
86positive regulation of T cell cytokine production (GO:0002726)2.55776131
87tRNA processing (GO:0008033)2.54931702
88positive regulation of T-helper 1 type immune response (GO:0002827)2.54815567
89DNA catabolic process, exonucleolytic (GO:0000738)2.54615378
90GPI anchor metabolic process (GO:0006505)2.53406563
91cellular response to interleukin-15 (GO:0071350)2.52856237
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52161581
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.48484395
94termination of RNA polymerase III transcription (GO:0006386)2.48484395
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48074188
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.47199703
97protein-cofactor linkage (GO:0018065)2.46853508
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.46846711
99regulation of hypersensitivity (GO:0002883)2.45689421
100cullin deneddylation (GO:0010388)2.45656339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.73463086
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58003272
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40239195
4ZNF274_21170338_ChIP-Seq_K562_Hela3.13260918
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.09760122
6VDR_22108803_ChIP-Seq_LS180_Human2.67315949
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64981826
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61329872
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.48803675
10VDR_23849224_ChIP-Seq_CD4+_Human2.40885199
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34133314
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34010732
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23633266
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17451984
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.12703304
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.07931703
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07437416
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.96787299
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96116985
20ELK1_19687146_ChIP-ChIP_HELA_Human1.88868432
21TP53_22573176_ChIP-Seq_HFKS_Human1.84276436
22FOXP3_21729870_ChIP-Seq_TREG_Human1.83972716
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.82769576
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77716619
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75030152
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71446269
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66871058
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.65443806
29GATA3_26560356_Chip-Seq_TH2_Human1.64076169
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.63756381
31FOXA1_27270436_Chip-Seq_PROSTATE_Human1.63756381
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61995862
33EWS_26573619_Chip-Seq_HEK293_Human1.61447261
34MYC_18940864_ChIP-ChIP_HL60_Human1.58748316
35TAF15_26573619_Chip-Seq_HEK293_Human1.58422615
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46032057
37AR_20517297_ChIP-Seq_VCAP_Human1.45593039
38NANOG_19829295_ChIP-Seq_ESCs_Human1.44014360
39SOX2_19829295_ChIP-Seq_ESCs_Human1.44014360
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.43560888
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43331753
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40753611
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.40066373
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39515145
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37120928
46IRF1_19129219_ChIP-ChIP_H3396_Human1.33198189
47ER_23166858_ChIP-Seq_MCF-7_Human1.30101906
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.29294372
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29117187
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28947090
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28647586
52NANOG_20526341_ChIP-Seq_ESCs_Human1.24661289
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22854187
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22765333
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22691940
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22259193
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22012474
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21444219
59P300_19829295_ChIP-Seq_ESCs_Human1.21154735
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21135376
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20374746
62FUS_26573619_Chip-Seq_HEK293_Human1.19809464
63TAF2_19829295_ChIP-Seq_ESCs_Human1.19692761
64FOXH1_21741376_ChIP-Seq_EPCs_Human1.18694091
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18045707
66ERG_20517297_ChIP-Seq_VCAP_Human1.17870931
67CBP_20019798_ChIP-Seq_JUKART_Human1.16641747
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16641747
69HOXB7_26014856_ChIP-Seq_BT474_Human1.16628662
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16386917
71CIITA_25753668_ChIP-Seq_RAJI_Human1.16366908
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16315932
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14893029
74NCOR_22424771_ChIP-Seq_293T_Human1.13689600
75IGF1R_20145208_ChIP-Seq_DFB_Human1.13380091
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12549567
77GATA3_26560356_Chip-Seq_TH1_Human1.10541411
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09957627
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08755699
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.07693786
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07643113
82MYB_26560356_Chip-Seq_TH2_Human1.05602229
83MYC_19829295_ChIP-Seq_ESCs_Human1.03860516
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02973277
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02942838
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02777891
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.02046241
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01518892
89ERA_21632823_ChIP-Seq_H3396_Human1.01223574
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.00880603
91MYC_18555785_ChIP-Seq_MESCs_Mouse0.99819195
92RBPJ_21746931_ChIP-Seq_IB4_Human0.99667148
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99349516
94P53_21459846_ChIP-Seq_SAOS-2_Human0.98644559
95TCF4_22108803_ChIP-Seq_LS180_Human0.97825035
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96696495
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96641647
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95536527
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93669046
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93082659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.03261865
2MP0001835_abnormal_antigen_presentation4.01638758
3MP0005671_abnormal_response_to3.38649703
4MP0008877_abnormal_DNA_methylation2.62253514
5MP0002102_abnormal_ear_morphology2.45092143
6MP0003011_delayed_dark_adaptation2.43258280
7MP0005646_abnormal_pituitary_gland2.36575703
8MP0008872_abnormal_physiological_respon2.35163653
9MP0006072_abnormal_retinal_apoptosis2.22819053
10MP0005377_hearing/vestibular/ear_phenot2.19385419
11MP0003878_abnormal_ear_physiology2.19385419
12MP0009785_altered_susceptibility_to2.16815678
13MP0001800_abnormal_humoral_immune2.09226013
14MP0002148_abnormal_hypersensitivity_rea2.07337266
15MP0006292_abnormal_olfactory_placode2.04323543
16MP0003724_increased_susceptibility_to1.95186668
17MP0002166_altered_tumor_susceptibility1.94559109
18MP0002138_abnormal_hepatobiliary_system1.84307784
19MP0001968_abnormal_touch/_nociception1.83748269
20MP0002736_abnormal_nociception_after1.79628298
21MP0002006_tumorigenesis1.77260427
22MP0009333_abnormal_splenocyte_physiolog1.75970561
23MP0002876_abnormal_thyroid_physiology1.74862549
24MP0003786_premature_aging1.72251474
25MP0005000_abnormal_immune_tolerance1.65080999
26MP0005551_abnormal_eye_electrophysiolog1.63968358
27MP0001986_abnormal_taste_sensitivity1.61717175
28MP0002723_abnormal_immune_serum1.59920104
29MP0005387_immune_system_phenotype1.58207712
30MP0001790_abnormal_immune_system1.58207712
31MP0003195_calcinosis1.56391922
32MP0000427_abnormal_hair_cycle1.47593540
33MP0005645_abnormal_hypothalamus_physiol1.46932741
34MP0002452_abnormal_antigen_presenting1.43927721
35MP0004145_abnormal_muscle_electrophysio1.41965764
36MP0001819_abnormal_immune_cell1.39520881
37MP0002420_abnormal_adaptive_immunity1.39099667
38MP0005084_abnormal_gallbladder_morpholo1.38082128
39MP0005253_abnormal_eye_physiology1.33892741
40MP0004147_increased_porphyrin_level1.33318754
41MP0001919_abnormal_reproductive_system1.31874130
42MP0005389_reproductive_system_phenotype1.31519719
43MP0000685_abnormal_immune_system1.29934711
44MP0003718_maternal_effect1.29090864
45MP0004885_abnormal_endolymph1.28653794
46MP0003763_abnormal_thymus_physiology1.27202679
47MP0002277_abnormal_respiratory_mucosa1.18369028
48MP0008995_early_reproductive_senescence1.17783243
49MP0009764_decreased_sensitivity_to1.15939229
50MP0010155_abnormal_intestine_physiology1.15697763
51MP0006036_abnormal_mitochondrial_physio1.14737552
52MP0003866_abnormal_defecation1.12393181
53MP0008058_abnormal_DNA_repair1.11581747
54MP0003252_abnormal_bile_duct1.08847508
55MP0008775_abnormal_heart_ventricle1.08796139
56MP0002837_dystrophic_cardiac_calcinosis1.07447661
57MP0001845_abnormal_inflammatory_respons1.07119096
58MP0001765_abnormal_ion_homeostasis1.04625885
59MP0005025_abnormal_response_to1.02963024
60MP0002272_abnormal_nervous_system1.00220508
61MP0005636_abnormal_mineral_homeostasis0.99675339
62MP0000716_abnormal_immune_system0.96165013
63MP0000689_abnormal_spleen_morphology0.95056312
64MP0001501_abnormal_sleep_pattern0.94165227
65MP0002160_abnormal_reproductive_system0.92798603
66MP0005075_abnormal_melanosome_morpholog0.92224425
67MP0005085_abnormal_gallbladder_physiolo0.92187122
68MP0001984_abnormal_olfaction0.91988822
69MP0002398_abnormal_bone_marrow0.91415748
70MP0000230_abnormal_systemic_arterial0.89869894
71MP0001873_stomach_inflammation0.87796711
72MP0004142_abnormal_muscle_tone0.87074449
73MP0009745_abnormal_behavioral_response0.86606498
74MP0005167_abnormal_blood-brain_barrier0.84920896
75MP0004043_abnormal_pH_regulation0.84274074
76MP0003787_abnormal_imprinting0.83638386
77MP0008469_abnormal_protein_level0.83524852
78MP0005410_abnormal_fertilization0.83393406
79MP0000372_irregular_coat_pigmentation0.83331053
80MP0001905_abnormal_dopamine_level0.83293121
81MP0000516_abnormal_urinary_system0.83103457
82MP0005367_renal/urinary_system_phenotyp0.83103457
83MP0005332_abnormal_amino_acid0.82465831
84MP0001929_abnormal_gametogenesis0.82443514
85MP0001502_abnormal_circadian_rhythm0.81473449
86MP0004019_abnormal_vitamin_homeostasis0.81461681
87MP0002210_abnormal_sex_determination0.81350897
88MP0001853_heart_inflammation0.80000074
89MP0006276_abnormal_autonomic_nervous0.79186553
90MP0000653_abnormal_sex_gland0.79140211
91MP0002693_abnormal_pancreas_physiology0.78260331
92MP0003186_abnormal_redox_activity0.77230263
93MP0002429_abnormal_blood_cell0.76521424
94MP0003693_abnormal_embryo_hatching0.75831307
95MP0001661_extended_life_span0.75277130
96MP0001764_abnormal_homeostasis0.74396425
97MP0001119_abnormal_female_reproductive0.74023328
98MP0003638_abnormal_response/metabolism_0.73925888
99MP0003436_decreased_susceptibility_to0.73225902
100MP0004215_abnormal_myocardial_fiber0.71908613

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.13365019
23-Methylglutaconic aciduria (HP:0003535)3.61979362
3Mitochondrial inheritance (HP:0001427)3.59182480
4IgG deficiency (HP:0004315)3.57909484
5Acute necrotizing encephalopathy (HP:0006965)3.48137354
6Increased CSF lactate (HP:0002490)3.47718897
7Congenital stationary night blindness (HP:0007642)3.32701550
8Progressive macrocephaly (HP:0004481)3.29173867
9Increased hepatocellular lipid droplets (HP:0006565)3.24768032
10Lipid accumulation in hepatocytes (HP:0006561)3.18489408
11Testicular atrophy (HP:0000029)3.17981373
12Congenital, generalized hypertrichosis (HP:0004540)3.13857482
13Methylmalonic acidemia (HP:0002912)3.07444155
14Elevated erythrocyte sedimentation rate (HP:0003565)3.03349574
15Abnormal mitochondria in muscle tissue (HP:0008316)2.95698262
16Hepatocellular necrosis (HP:0001404)2.93518788
17Acute encephalopathy (HP:0006846)2.93263509
18Abnormality of the renal cortex (HP:0011035)2.87507933
19Abnormality of the prostate (HP:0008775)2.87426953
20Abolished electroretinogram (ERG) (HP:0000550)2.87263298
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80555450
22Pancreatic cysts (HP:0001737)2.80403553
23Renal Fanconi syndrome (HP:0001994)2.71717967
24Hypoproteinemia (HP:0003075)2.68949502
25Hepatic necrosis (HP:0002605)2.65304911
26Increased serum lactate (HP:0002151)2.57346602
27Aplastic anemia (HP:0001915)2.53099368
28Renal cortical cysts (HP:0000803)2.52914074
29Nephronophthisis (HP:0000090)2.50706152
30Molar tooth sign on MRI (HP:0002419)2.49589814
31Abnormality of midbrain morphology (HP:0002418)2.49589814
32Polydipsia (HP:0001959)2.47867615
33Abnormal drinking behavior (HP:0030082)2.47867615
34Type II lissencephaly (HP:0007260)2.47037438
35Attenuation of retinal blood vessels (HP:0007843)2.46743511
36Methylmalonic aciduria (HP:0012120)2.43914474
37Exertional dyspnea (HP:0002875)2.38346837
38Optic disc pallor (HP:0000543)2.37674475
39Cerebral edema (HP:0002181)2.33115123
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30541434
41Abnormality of B cell number (HP:0010975)2.28845490
42Abnormal rod and cone electroretinograms (HP:0008323)2.27712955
43Abnormality of the renal medulla (HP:0100957)2.23888126
44Pancreatic fibrosis (HP:0100732)2.23025796
45Stomach cancer (HP:0012126)2.22350701
46Increased intramyocellular lipid droplets (HP:0012240)2.21669124
47Prostate neoplasm (HP:0100787)2.16136006
48Abnormality of T cells (HP:0002843)2.13557370
49Azoospermia (HP:0000027)2.13527296
50Lactic acidosis (HP:0003128)2.13050163
51Abnormality of T cell physiology (HP:0011840)2.12125613
52Thyroiditis (HP:0100646)2.10572617
53True hermaphroditism (HP:0010459)2.09430360
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09178169
55Increased IgM level (HP:0003496)2.07344825
56Alveolar cell carcinoma (HP:0006519)2.06411760
57Panhypogammaglobulinemia (HP:0003139)2.02966274
58Hypomagnesemia (HP:0002917)2.01859702
59Polyuria (HP:0000103)2.01742889
60Pendular nystagmus (HP:0012043)2.00508604
61Lethargy (HP:0001254)2.00428715
62Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98520459
63Abnormality of the vitamin B12 metabolism (HP:0004341)1.96842013
64Opisthotonus (HP:0002179)1.95218688
65Type 2 muscle fiber atrophy (HP:0003554)1.93115547
66Pancytopenia (HP:0001876)1.90406210
67Increased muscle lipid content (HP:0009058)1.87908211
68Autoimmune hemolytic anemia (HP:0001890)1.87513546
69Abnormality of vitamin B metabolism (HP:0004340)1.87440463
70Abnormal spermatogenesis (HP:0008669)1.87362223
71Aplasia/hypoplasia of the uterus (HP:0008684)1.87225435
72Dyschromatopsia (HP:0007641)1.86635520
73Abnormality of T cell number (HP:0011839)1.86078065
74Parakeratosis (HP:0001036)1.83518782
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83436052
76Abnormality of alanine metabolism (HP:0010916)1.83436052
77Hyperalaninemia (HP:0003348)1.83436052
78Supernumerary spleens (HP:0009799)1.82439537
79B lymphocytopenia (HP:0010976)1.82036610
80Dicarboxylic aciduria (HP:0003215)1.81981274
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81981274
82Colon cancer (HP:0003003)1.81070173
83Decreased central vision (HP:0007663)1.79799122
84Respiratory failure (HP:0002878)1.79762061
85T lymphocytopenia (HP:0005403)1.79453879
86Autoimmune thrombocytopenia (HP:0001973)1.78807692
87Severe combined immunodeficiency (HP:0004430)1.76099407
88Hypoplasia of the uterus (HP:0000013)1.75262817
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.73905478
90Absent/shortened dynein arms (HP:0200106)1.73905478
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73869144
92Oral leukoplakia (HP:0002745)1.71784511
93Glycosuria (HP:0003076)1.71359069
94Abnormality of urine glucose concentration (HP:0011016)1.71359069
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70672528
96Absent thumb (HP:0009777)1.70218434
97Abnormal biliary tract physiology (HP:0012439)1.69650527
98Bile duct proliferation (HP:0001408)1.69650527
99Neoplasm of the tracheobronchial system (HP:0100552)1.69509610
100Delayed CNS myelination (HP:0002188)1.69412532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.71777985
2TLK13.63280341
3MAP4K23.62608402
4NUAK13.59830153
5FRK3.29448916
6ZAK3.28738399
7MAP3K122.33902692
8TAOK32.27575181
9CDK192.26629774
10ADRBK22.23763261
11STK162.08107890
12EIF2AK32.06959465
13GRK12.01425512
14BMPR21.88748187
15NEK11.79221201
16MST41.76756589
17OXSR11.71186475
18MAP4K11.68049691
19VRK21.66939025
20BCKDK1.42936981
21NME11.38042725
22IKBKB1.38002296
23WNK41.30380473
24PHKG11.29499995
25PHKG21.29499995
26TRPM71.26611532
27VRK11.25456272
28TEC1.19942026
29KIT1.19443354
30MYLK1.16855672
31TIE11.15770863
32PLK21.11163032
33FES1.06169520
34EIF2AK21.05823718
35PINK11.05399398
36TRIM281.03477293
37BMPR1B1.03365762
38ERBB31.02801864
39ITK1.00104843
40PLK30.98719464
41SYK0.97914808
42PBK0.97826372
43EIF2AK10.94397271
44PIK3CA0.93011291
45STK390.92329740
46SCYL20.91306824
47INSRR0.90662572
48DAPK10.88919201
49IKBKE0.86755902
50CSF1R0.86305964
51WNK30.81529630
52TAF10.79775003
53ILK0.78395699
54TSSK60.77144343
55DYRK20.76425878
56MAP2K60.74579773
57GRK60.73702560
58MAPKAPK30.73605348
59GRK50.71480643
60MKNK10.70858561
61CAMKK20.69740326
62DAPK20.69564615
63PIK3CG0.68420993
64BUB10.67820197
65LYN0.67466845
66CSNK1G30.66603620
67PLK40.65215363
68MAPKAPK50.64911000
69LCK0.64663492
70PRKCQ0.63616367
71TBK10.62748788
72SRPK10.62416433
73CSNK1A1L0.61074870
74TNIK0.60834405
75BTK0.59754615
76MAP3K140.59365542
77RPS6KA50.58978288
78ADRBK10.57305891
79KDR0.56377614
80IGF1R0.55615607
81CSNK1G20.54510273
82CHUK0.54473083
83PASK0.49785834
84PTK2B0.49551462
85MAP2K20.48933564
86MKNK20.48259388
87PRKCE0.48042371
88MUSK0.47136835
89CSNK1G10.45724019
90OBSCN0.43862913
91ATR0.42817933
92CDC70.37734274
93JAK30.37655622
94PDK20.37636319
95PRKCA0.36990760
96AURKB0.36456163
97PRKCG0.36379765
98ABL10.35303201
99TGFBR10.33775723
100GRK70.32817712

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.60070627
2Caffeine metabolism_Homo sapiens_hsa002323.89298330
3Allograft rejection_Homo sapiens_hsa053303.78638306
4Autoimmune thyroid disease_Homo sapiens_hsa053203.56736822
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.48128130
6Graft-versus-host disease_Homo sapiens_hsa053323.17144576
7Proteasome_Homo sapiens_hsa030503.15014905
8Type I diabetes mellitus_Homo sapiens_hsa049402.88656560
9Oxidative phosphorylation_Homo sapiens_hsa001902.77876099
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38040452
11Parkinsons disease_Homo sapiens_hsa050122.20744753
12Protein export_Homo sapiens_hsa030602.17779130
13Ribosome_Homo sapiens_hsa030101.85950715
14Antigen processing and presentation_Homo sapiens_hsa046121.75094070
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74221447
16One carbon pool by folate_Homo sapiens_hsa006701.71855735
17RNA polymerase_Homo sapiens_hsa030201.68418133
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66508158
19Primary immunodeficiency_Homo sapiens_hsa053401.61918983
20Rheumatoid arthritis_Homo sapiens_hsa053231.61549169
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48918927
22Alzheimers disease_Homo sapiens_hsa050101.41855201
23Homologous recombination_Homo sapiens_hsa034401.31110355
24Tryptophan metabolism_Homo sapiens_hsa003801.28122942
25Phototransduction_Homo sapiens_hsa047441.27658119
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25072774
27Linoleic acid metabolism_Homo sapiens_hsa005911.23391698
28Huntingtons disease_Homo sapiens_hsa050161.20618662
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18425787
30Basal transcription factors_Homo sapiens_hsa030221.17484099
31Nitrogen metabolism_Homo sapiens_hsa009101.17163288
32RNA degradation_Homo sapiens_hsa030181.16692103
33Staphylococcus aureus infection_Homo sapiens_hsa051501.09858652
34Cardiac muscle contraction_Homo sapiens_hsa042601.08390854
35Hematopoietic cell lineage_Homo sapiens_hsa046401.05818584
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04086979
37Viral myocarditis_Homo sapiens_hsa054161.03162255
38Fanconi anemia pathway_Homo sapiens_hsa034600.96328650
39Olfactory transduction_Homo sapiens_hsa047400.93954313
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93674656
41Propanoate metabolism_Homo sapiens_hsa006400.93583572
42Leishmaniasis_Homo sapiens_hsa051400.92381885
43Chemical carcinogenesis_Homo sapiens_hsa052040.91566368
44Butanoate metabolism_Homo sapiens_hsa006500.90961287
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89500889
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87465484
47Peroxisome_Homo sapiens_hsa041460.84976300
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84525841
49Systemic lupus erythematosus_Homo sapiens_hsa053220.80580393
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80040999
51Selenocompound metabolism_Homo sapiens_hsa004500.78761345
52Mismatch repair_Homo sapiens_hsa034300.78202158
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75216116
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74102898
55Arachidonic acid metabolism_Homo sapiens_hsa005900.72210127
56Pyrimidine metabolism_Homo sapiens_hsa002400.70492643
57Purine metabolism_Homo sapiens_hsa002300.65549323
58RNA transport_Homo sapiens_hsa030130.63217967
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62922730
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60969304
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60472318
62Ether lipid metabolism_Homo sapiens_hsa005650.58445550
63Retinol metabolism_Homo sapiens_hsa008300.56916471
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.54707911
65Spliceosome_Homo sapiens_hsa030400.53168380
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51636551
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51314360
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.50731527
69Collecting duct acid secretion_Homo sapiens_hsa049660.50348802
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49144453
71Herpes simplex infection_Homo sapiens_hsa051680.48290344
72Nucleotide excision repair_Homo sapiens_hsa034200.46356635
73Metabolic pathways_Homo sapiens_hsa011000.46344721
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.45985196
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45582788
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44502058
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.43312943
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.40276928
79Glutathione metabolism_Homo sapiens_hsa004800.39961716
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.39751922
81Fat digestion and absorption_Homo sapiens_hsa049750.38533441
82T cell receptor signaling pathway_Homo sapiens_hsa046600.37919485
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37001687
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.34939164
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33298046
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30754270
87Salivary secretion_Homo sapiens_hsa049700.30228269
88Regulation of autophagy_Homo sapiens_hsa041400.30125198
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28950725
90Ovarian steroidogenesis_Homo sapiens_hsa049130.27935667
91Fatty acid degradation_Homo sapiens_hsa000710.27686226
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.26404730
93beta-Alanine metabolism_Homo sapiens_hsa004100.25210116
94Non-homologous end-joining_Homo sapiens_hsa034500.24803730
95Sulfur metabolism_Homo sapiens_hsa009200.24727043
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23768978
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23253144
98Epstein-Barr virus infection_Homo sapiens_hsa051690.23212412
99Base excision repair_Homo sapiens_hsa034100.22997578
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22258432

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