RPL7P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.51900541
2cytidine metabolic process (GO:0046087)5.51249350
3cytidine catabolic process (GO:0006216)5.51249350
4cytidine deamination (GO:0009972)5.51249350
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.30165313
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.70059869
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27686291
8ATP synthesis coupled proton transport (GO:0015986)4.23898477
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23898477
10ribosomal small subunit assembly (GO:0000028)4.14265143
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67354692
12respiratory electron transport chain (GO:0022904)3.37176096
13electron transport chain (GO:0022900)3.35455272
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31835298
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31835298
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30916796
17protein neddylation (GO:0045116)3.30347324
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27592108
19positive thymic T cell selection (GO:0045059)3.27017103
20positive T cell selection (GO:0043368)3.22423787
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16783085
22positive regulation of alpha-beta T cell proliferation (GO:0046641)3.15742078
23actin nucleation (GO:0045010)3.13423239
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13344822
25positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09141150
26mast cell activation (GO:0045576)3.09075171
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04892803
28negative regulation of T cell apoptotic process (GO:0070233)3.03660809
29regulation of regulatory T cell differentiation (GO:0045589)3.03318236
30protein complex biogenesis (GO:0070271)3.03169241
31tryptophan catabolic process (GO:0006569)2.99534838
32indole-containing compound catabolic process (GO:0042436)2.99534838
33indolalkylamine catabolic process (GO:0046218)2.99534838
34negative T cell selection (GO:0043383)2.98631736
35platelet dense granule organization (GO:0060155)2.98390868
36response to pheromone (GO:0019236)2.97095114
37kynurenine metabolic process (GO:0070189)2.96578220
38cellular response to interleukin-15 (GO:0071350)2.93755245
39regulation of B cell receptor signaling pathway (GO:0050855)2.92602134
40positive regulation of calcium-mediated signaling (GO:0050850)2.91855015
41regulation of alpha-beta T cell proliferation (GO:0046640)2.86014040
42positive regulation of defense response to virus by host (GO:0002230)2.85871308
43response to interferon-beta (GO:0035456)2.84043033
44regulation of T cell mediated cytotoxicity (GO:0001914)2.83496496
45immunoglobulin mediated immune response (GO:0016064)2.80657456
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80392131
47positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.79150274
48GPI anchor metabolic process (GO:0006505)2.77277278
49regulation of cellular amino acid metabolic process (GO:0006521)2.77242674
50sequestering of actin monomers (GO:0042989)2.76226371
51respiratory chain complex IV assembly (GO:0008535)2.75988035
52GPI anchor biosynthetic process (GO:0006506)2.75782652
53regulation of activation of Janus kinase activity (GO:0010533)2.75730880
54proteasome assembly (GO:0043248)2.74566572
55positive regulation of interleukin-8 secretion (GO:2000484)2.73406873
56positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.72975604
57positive regulation of interleukin-17 production (GO:0032740)2.70720552
58T cell receptor signaling pathway (GO:0050852)2.70543925
59regulation of interleukin-8 secretion (GO:2000482)2.69005132
60positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.68549316
61cytochrome complex assembly (GO:0017004)2.67986858
62regulation of chronic inflammatory response (GO:0002676)2.67260375
63regulation of T cell receptor signaling pathway (GO:0050856)2.66360723
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.66308480
65NADH dehydrogenase complex assembly (GO:0010257)2.66308480
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66308480
67mitochondrial respiratory chain complex assembly (GO:0033108)2.64460863
68mannosylation (GO:0097502)2.64319979
69T cell costimulation (GO:0031295)2.62371118
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62325361
71tryptophan metabolic process (GO:0006568)2.62130509
72lymphocyte costimulation (GO:0031294)2.61916115
73negative regulation by host of viral transcription (GO:0043922)2.60802837
74regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.60661083
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.60086953
76mast cell activation involved in immune response (GO:0002279)2.59803355
77mast cell degranulation (GO:0043303)2.59803355
78regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54909367
79water-soluble vitamin biosynthetic process (GO:0042364)2.54890924
80hydrogen ion transmembrane transport (GO:1902600)2.54348929
81preassembly of GPI anchor in ER membrane (GO:0016254)2.53859927
82viral transcription (GO:0019083)2.53554361
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53354865
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53354865
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53354865
86regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.53114409
87indolalkylamine metabolic process (GO:0006586)2.52688914
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52235208
89ribosomal large subunit biogenesis (GO:0042273)2.51745845
90proton transport (GO:0015992)2.51460239
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50636390
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50236707
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.50236707
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50145008
95positive regulation of prostaglandin secretion (GO:0032308)2.49970939
96axoneme assembly (GO:0035082)2.49655843
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.49642177
98purine deoxyribonucleotide catabolic process (GO:0009155)2.48974507
99behavioral response to nicotine (GO:0035095)2.48885602
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47947392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.45731105
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.56860101
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26362018
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.12294786
5VDR_22108803_ChIP-Seq_LS180_Human2.97225755
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89103066
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83757333
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69506941
9ZNF274_21170338_ChIP-Seq_K562_Hela2.54583527
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.51175427
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47633219
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33353082
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31509089
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29055321
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19968175
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.18713543
17VDR_23849224_ChIP-Seq_CD4+_Human2.17967701
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12774470
19IGF1R_20145208_ChIP-Seq_DFB_Human2.04834742
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92229622
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89273517
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88101615
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87105288
24MYB_26560356_Chip-Seq_TH2_Human1.74037752
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72837967
26ELK1_19687146_ChIP-ChIP_HELA_Human1.71296318
27GATA3_26560356_Chip-Seq_TH2_Human1.69616981
28FOXP3_21729870_ChIP-Seq_TREG_Human1.68538243
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66016178
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.61269052
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57509943
32TP53_22573176_ChIP-Seq_HFKS_Human1.53045213
33EWS_26573619_Chip-Seq_HEK293_Human1.52131666
34MYC_18940864_ChIP-ChIP_HL60_Human1.51955259
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51039633
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49596671
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.49596671
38AR_20517297_ChIP-Seq_VCAP_Human1.48920188
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.43895500
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43433462
41ER_23166858_ChIP-Seq_MCF-7_Human1.41235572
42GATA3_27048872_Chip-Seq_THYMUS_Human1.39118497
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.39055379
44TAF15_26573619_Chip-Seq_HEK293_Human1.38590628
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36413347
46NANOG_19829295_ChIP-Seq_ESCs_Human1.35074885
47SOX2_19829295_ChIP-Seq_ESCs_Human1.35074885
48RUNX_20019798_ChIP-Seq_JUKART_Human1.33212572
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32598321
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31901646
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31609852
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30062079
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29147481
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27043500
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26743664
56P300_19829295_ChIP-Seq_ESCs_Human1.25343427
57EZH2_22144423_ChIP-Seq_EOC_Human1.24827565
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23945002
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21662590
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21257207
61CBP_20019798_ChIP-Seq_JUKART_Human1.20966117
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20966117
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20820474
64FUS_26573619_Chip-Seq_HEK293_Human1.19366648
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19321631
66NCOR_22424771_ChIP-Seq_293T_Human1.18330681
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17164165
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.16963178
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16069483
70IRF1_19129219_ChIP-ChIP_H3396_Human1.15974545
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15658912
72NANOG_20526341_ChIP-Seq_ESCs_Human1.15574484
73TAF2_19829295_ChIP-Seq_ESCs_Human1.15379453
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15216780
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14549230
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.14015392
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13810871
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12362631
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09809879
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08990960
81FOXH1_21741376_ChIP-Seq_EPCs_Human1.08564027
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08092667
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05873632
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04550251
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04060785
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03653899
87BCAT_22108803_ChIP-Seq_LS180_Human1.03511571
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03397318
89ERG_20517297_ChIP-Seq_VCAP_Human1.02618327
90MYC_19829295_ChIP-Seq_ESCs_Human1.00805291
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99655765
92HTT_18923047_ChIP-ChIP_STHdh_Human0.98902636
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.98273535
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95720701
95SPI1_23547873_ChIP-Seq_NB4_Human0.95244577
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95067753
97HOXB7_26014856_ChIP-Seq_BT474_Human0.94947699
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94923193
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93893770
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93837015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.90264764
2MP0001835_abnormal_antigen_presentation3.82492811
3MP0009785_altered_susceptibility_to2.69949381
4MP0002166_altered_tumor_susceptibility2.30851402
5MP0002148_abnormal_hypersensitivity_rea2.28574321
6MP0006072_abnormal_retinal_apoptosis2.15814243
7MP0001800_abnormal_humoral_immune2.15015713
8MP0003763_abnormal_thymus_physiology2.13900161
9MP0005000_abnormal_immune_tolerance2.12738695
10MP0009379_abnormal_foot_pigmentation1.99059308
11MP0000685_abnormal_immune_system1.94138678
12MP0005645_abnormal_hypothalamus_physiol1.93491357
13MP0004147_increased_porphyrin_level1.93475837
14MP0009333_abnormal_splenocyte_physiolog1.90107717
15MP0002006_tumorigenesis1.86798784
16MP0002837_dystrophic_cardiac_calcinosis1.85837591
17MP0002723_abnormal_immune_serum1.83016321
18MP0003646_muscle_fatigue1.82405928
19MP0002876_abnormal_thyroid_physiology1.79780402
20MP0000372_irregular_coat_pigmentation1.76960619
21MP0005075_abnormal_melanosome_morpholog1.76933112
22MP0008872_abnormal_physiological_respon1.75351995
23MP0003806_abnormal_nucleotide_metabolis1.74740091
24MP0008875_abnormal_xenobiotic_pharmacok1.73542390
25MP0002420_abnormal_adaptive_immunity1.72670519
26MP0001819_abnormal_immune_cell1.71318928
27MP0006292_abnormal_olfactory_placode1.71120538
28MP0002102_abnormal_ear_morphology1.68939205
29MP0005387_immune_system_phenotype1.68679579
30MP0001790_abnormal_immune_system1.68679579
31MP0002138_abnormal_hepatobiliary_system1.68207743
32MP0001873_stomach_inflammation1.66063158
33MP0008877_abnormal_DNA_methylation1.65655724
34MP0002452_abnormal_antigen_presenting1.65422852
35MP0005646_abnormal_pituitary_gland1.63479509
36MP0005551_abnormal_eye_electrophysiolog1.63423522
37MP0003866_abnormal_defecation1.61433562
38MP0005025_abnormal_response_to1.59692034
39MP0003724_increased_susceptibility_to1.50044059
40MP0005084_abnormal_gallbladder_morpholo1.42493056
41MP0004142_abnormal_muscle_tone1.36553332
42MP0009764_decreased_sensitivity_to1.36061433
43MP0004145_abnormal_muscle_electrophysio1.35761066
44MP0000716_abnormal_immune_system1.33808410
45MP0005253_abnormal_eye_physiology1.30519528
46MP0010155_abnormal_intestine_physiology1.29651838
47MP0002398_abnormal_bone_marrow1.29534614
48MP0003011_delayed_dark_adaptation1.29330860
49MP0001968_abnormal_touch/_nociception1.28409325
50MP0001986_abnormal_taste_sensitivity1.28290886
51MP0006082_CNS_inflammation1.28017382
52MP0001905_abnormal_dopamine_level1.26832922
53MP0003786_premature_aging1.25836340
54MP0003195_calcinosis1.25553513
55MP0004885_abnormal_endolymph1.22868953
56MP0008995_early_reproductive_senescence1.16186065
57MP0001845_abnormal_inflammatory_respons1.16001662
58MP0005389_reproductive_system_phenotype1.14703144
59MP0001501_abnormal_sleep_pattern1.13925164
60MP0000689_abnormal_spleen_morphology1.13895699
61MP0001919_abnormal_reproductive_system1.10279593
62MP0002163_abnormal_gland_morphology1.07016992
63MP0003787_abnormal_imprinting1.06673145
64MP0002405_respiratory_system_inflammati1.05639604
65MP0002419_abnormal_innate_immunity1.05079534
66MP0005377_hearing/vestibular/ear_phenot1.04698458
67MP0003878_abnormal_ear_physiology1.04698458
68MP0002736_abnormal_nociception_after1.01280166
69MP0003252_abnormal_bile_duct1.00039976
70MP0002429_abnormal_blood_cell0.99049136
71MP0002722_abnormal_immune_system0.96902355
72MP0001764_abnormal_homeostasis0.95171828
73MP0006276_abnormal_autonomic_nervous0.94391133
74MP0006036_abnormal_mitochondrial_physio0.94327644
75MP0008469_abnormal_protein_level0.92894118
76MP0005636_abnormal_mineral_homeostasis0.90981329
77MP0002095_abnormal_skin_pigmentation0.89510370
78MP0002234_abnormal_pharynx_morphology0.89086443
79MP0001765_abnormal_ion_homeostasis0.88852943
80MP0005410_abnormal_fertilization0.87410762
81MP0000703_abnormal_thymus_morphology0.85882822
82MP0010386_abnormal_urinary_bladder0.84937655
83MP0003436_decreased_susceptibility_to0.84926811
84MP0003880_abnormal_central_pattern0.83973150
85MP0002933_joint_inflammation0.83361420
86MP0002693_abnormal_pancreas_physiology0.82507653
87MP0005360_urolithiasis0.81940283
88MP0002272_abnormal_nervous_system0.81688955
89MP0002277_abnormal_respiratory_mucosa0.81325907
90MP0005085_abnormal_gallbladder_physiolo0.77307521
91MP0005174_abnormal_tail_pigmentation0.76165743
92MP0001485_abnormal_pinna_reflex0.76057592
93MP0000465_gastrointestinal_hemorrhage0.75976736
94MP0009745_abnormal_behavioral_response0.75841400
95MP0005464_abnormal_platelet_physiology0.75218558
96MP0002638_abnormal_pupillary_reflex0.75170367
97MP0002160_abnormal_reproductive_system0.74747357
98MP0005379_endocrine/exocrine_gland_phen0.72472952
99MP0009643_abnormal_urine_homeostasis0.70602995
100MP0001970_abnormal_pain_threshold0.68828861

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.02016072
2IgG deficiency (HP:0004315)3.98768684
3Elevated erythrocyte sedimentation rate (HP:0003565)3.75314102
4Mitochondrial inheritance (HP:0001427)3.68625716
5Severe combined immunodeficiency (HP:0004430)3.68493761
6Aplastic anemia (HP:0001915)3.67918738
7Acute necrotizing encephalopathy (HP:0006965)3.62755989
8Hypoproteinemia (HP:0003075)3.58517655
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.56750706
10T lymphocytopenia (HP:0005403)3.49258060
11Abnormality of T cell number (HP:0011839)3.44099612
123-Methylglutaconic aciduria (HP:0003535)3.41002065
13Hepatocellular necrosis (HP:0001404)3.36809675
14Thyroiditis (HP:0100646)3.30221139
15Increased CSF lactate (HP:0002490)3.29535906
16Abnormal rod and cone electroretinograms (HP:0008323)3.22434245
17Abnormal mitochondria in muscle tissue (HP:0008316)3.20277047
18Abnormality of B cell number (HP:0010975)3.20154637
19Pancreatic cysts (HP:0001737)3.12570786
20Progressive macrocephaly (HP:0004481)3.11987693
21Abnormality of the prostate (HP:0008775)3.10876408
22Hepatic necrosis (HP:0002605)3.03462556
23Acute encephalopathy (HP:0006846)3.03261524
24Abolished electroretinogram (ERG) (HP:0000550)2.96881709
25Increased hepatocellular lipid droplets (HP:0006565)2.91868086
26Congenital, generalized hypertrichosis (HP:0004540)2.87795209
27Lipid accumulation in hepatocytes (HP:0006561)2.83752116
28Combined immunodeficiency (HP:0005387)2.76464735
29B lymphocytopenia (HP:0010976)2.74621202
30Abnormality of T cells (HP:0002843)2.71353280
31Molar tooth sign on MRI (HP:0002419)2.68188232
32Abnormality of midbrain morphology (HP:0002418)2.68188232
33Attenuation of retinal blood vessels (HP:0007843)2.66079397
34Abnormality of eosinophils (HP:0001879)2.60935283
35Increased intramyocellular lipid droplets (HP:0012240)2.58544159
36Stomatitis (HP:0010280)2.57530533
37Pancreatic fibrosis (HP:0100732)2.56682962
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55890940
39Autoimmune hemolytic anemia (HP:0001890)2.54371977
40True hermaphroditism (HP:0010459)2.51909286
41Decreased central vision (HP:0007663)2.51430463
42Methylmalonic acidemia (HP:0002912)2.51098855
43Renal cortical cysts (HP:0000803)2.44851906
44Optic disc pallor (HP:0000543)2.43950946
45Cerebral edema (HP:0002181)2.39631379
46Increased IgM level (HP:0003496)2.36571198
47Renal Fanconi syndrome (HP:0001994)2.35038791
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32346011
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32346011
50Abnormality of the renal cortex (HP:0011035)2.29765723
51Increased serum lactate (HP:0002151)2.28385750
52Increased muscle lipid content (HP:0009058)2.20952050
53Panhypogammaglobulinemia (HP:0003139)2.18479314
54Absent/shortened dynein arms (HP:0200106)2.18202614
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.18202614
56Eosinophilia (HP:0001880)2.14454104
57Exertional dyspnea (HP:0002875)2.13732083
58Constricted visual fields (HP:0001133)2.11973288
59Lactic acidosis (HP:0003128)2.09807146
60Nephronophthisis (HP:0000090)2.08005199
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04824807
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03052032
63Chronic diarrhea (HP:0002028)2.01506823
64Hypothermia (HP:0002045)1.97712608
65Pancytopenia (HP:0001876)1.95597165
66Methylmalonic aciduria (HP:0012120)1.94942663
67Type 2 muscle fiber atrophy (HP:0003554)1.94865056
68Agammaglobulinemia (HP:0004432)1.92240521
69Type II lissencephaly (HP:0007260)1.90833440
70Lethargy (HP:0001254)1.89722114
71Abnormality of T cell physiology (HP:0011840)1.89016152
72Abnormal delayed hypersensitivity skin test (HP:0002963)1.88090119
73Encephalitis (HP:0002383)1.86669698
74Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85683114
75Aplasia/hypoplasia of the uterus (HP:0008684)1.85093198
76Respiratory failure (HP:0002878)1.83961346
77Abnormality of alanine metabolism (HP:0010916)1.83279437
78Hyperalaninemia (HP:0003348)1.83279437
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83279437
80Prostate neoplasm (HP:0100787)1.81713407
81Autoimmune thrombocytopenia (HP:0001973)1.81395308
82Cerebral palsy (HP:0100021)1.81103233
83Leukocytosis (HP:0001974)1.80791108
84Abnormal respiratory motile cilium morphology (HP:0005938)1.79809554
85Abnormal respiratory epithelium morphology (HP:0012253)1.79809554
86Medial flaring of the eyebrow (HP:0010747)1.79470323
87Abnormality of the renal medulla (HP:0100957)1.79303293
88Abnormality of male internal genitalia (HP:0000022)1.77681222
89Dicarboxylic aciduria (HP:0003215)1.77078400
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77078400
91Recurrent cutaneous fungal infections (HP:0011370)1.76096972
92Chronic mucocutaneous candidiasis (HP:0002728)1.76096972
93Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75234434
94Meningitis (HP:0001287)1.75180796
95Abnormal number of erythroid precursors (HP:0012131)1.75021608
96Abnormality of cells of the erythroid lineage (HP:0012130)1.74443078
97Pendular nystagmus (HP:0012043)1.74051443
98Chronic sinusitis (HP:0011109)1.73500651
99Type I transferrin isoform profile (HP:0003642)1.73261892
100Glycosuria (HP:0003076)1.70884364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.59676208
2KDR3.31596716
3CDK192.67278407
4TESK22.66568628
5TAOK32.59937690
6MAP4K22.59795480
7ZAK2.57905656
8TLK12.54744136
9FRK2.48799143
10ADRBK22.37174626
11GRK12.27943094
12NUAK12.27698199
13BCKDK2.17668904
14VRK22.02984422
15MAP4K11.95950940
16ITK1.76278439
17MAP3K121.73284621
18BMPR21.72520715
19KIT1.72307694
20EIF2AK31.58955497
21SCYL21.55559373
22STK161.53886191
23FES1.53747572
24MST41.52178345
25SYK1.47881905
26TEC1.41435347
27GRK61.32801401
28VRK11.32574315
29WNK41.29639832
30TIE11.24933877
31OXSR11.22459819
32PINK11.22372108
33CSF1R1.16954303
34MYLK1.15279901
35GRK71.11466121
36PASK1.10467776
37BMPR1B1.09847809
38IKBKB1.09010953
39MUSK1.08512261
40INSRR1.07092869
41ERBB31.06919526
42TRPM70.99591297
43WNK30.99553757
44LYN0.96131607
45LCK0.95921083
46BTK0.95189252
47PRKCQ0.94535659
48DAPK10.92343272
49DAPK20.90383520
50TNK20.84064665
51IKBKE0.81128476
52MAPKAPK30.78921514
53FLT30.75809549
54RPS6KA50.73953609
55MAP2K60.71984278
56LIMK10.71909841
57TRIM280.68369223
58PIK3CG0.68099766
59RPS6KA40.66395096
60OBSCN0.64225899
61MATK0.63965935
62IGF1R0.63486999
63MAPK130.63251341
64BUB10.62775446
65JAK30.62535083
66STK390.62317638
67PIK3CA0.61964179
68ADRBK10.61304333
69CDK80.60513594
70CSNK1G30.56984186
71CAMKK20.53873344
72ILK0.53811944
73CSK0.50545568
74ZAP700.50040781
75PHKG10.49899344
76PHKG20.49899344
77RIPK40.49809662
78PRKCE0.49430809
79CSNK1G10.47470287
80DYRK20.47438773
81PLK20.46619150
82DAPK30.45152834
83PRKCA0.44518982
84TBK10.44185025
85CSNK1G20.43200202
86HCK0.40932494
87PIM10.40911893
88GRK50.40685071
89PRKACA0.40175614
90EIF2AK20.38352665
91PLK40.38331274
92CDK30.37963853
93MAPKAPK50.36837894
94EIF2AK10.36799093
95ABL10.35576478
96TESK10.34369996
97CSNK2A10.32380425
98PRKCD0.31922254
99ACVR1B0.30988831
100CSNK1A1L0.29149240

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.74147016
2Allograft rejection_Homo sapiens_hsa053303.54078377
3Autoimmune thyroid disease_Homo sapiens_hsa053203.39787948
4Graft-versus-host disease_Homo sapiens_hsa053323.38481335
5Proteasome_Homo sapiens_hsa030503.36313827
6Primary immunodeficiency_Homo sapiens_hsa053403.26618416
7Oxidative phosphorylation_Homo sapiens_hsa001903.13910219
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.00302015
9Type I diabetes mellitus_Homo sapiens_hsa049402.97632340
10Ribosome_Homo sapiens_hsa030102.57821157
11Antigen processing and presentation_Homo sapiens_hsa046122.51609808
12Parkinsons disease_Homo sapiens_hsa050122.50629949
13Protein export_Homo sapiens_hsa030602.04827021
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94019040
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90895367
16Rheumatoid arthritis_Homo sapiens_hsa053231.85350474
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76425198
18RNA polymerase_Homo sapiens_hsa030201.74564670
19Phototransduction_Homo sapiens_hsa047441.69779873
20Hematopoietic cell lineage_Homo sapiens_hsa046401.69568772
21Alzheimers disease_Homo sapiens_hsa050101.63267152
22Linoleic acid metabolism_Homo sapiens_hsa005911.46302987
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45575649
24Huntingtons disease_Homo sapiens_hsa050161.44320413
25Caffeine metabolism_Homo sapiens_hsa002321.40148795
26Viral myocarditis_Homo sapiens_hsa054161.33721229
27Cardiac muscle contraction_Homo sapiens_hsa042601.31978301
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25338199
29RNA degradation_Homo sapiens_hsa030181.24522908
30Staphylococcus aureus infection_Homo sapiens_hsa051501.20187631
31Homologous recombination_Homo sapiens_hsa034401.14098349
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13652805
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09662899
34Nitrogen metabolism_Homo sapiens_hsa009101.02785661
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02620712
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98691228
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98521597
38Systemic lupus erythematosus_Homo sapiens_hsa053220.96341342
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92751748
40T cell receptor signaling pathway_Homo sapiens_hsa046600.85197093
41Propanoate metabolism_Homo sapiens_hsa006400.84660631
42Peroxisome_Homo sapiens_hsa041460.84185172
43Leishmaniasis_Homo sapiens_hsa051400.84171488
44Tryptophan metabolism_Homo sapiens_hsa003800.83262583
45Arachidonic acid metabolism_Homo sapiens_hsa005900.83161003
46Olfactory transduction_Homo sapiens_hsa047400.81857236
47Chemical carcinogenesis_Homo sapiens_hsa052040.81705325
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80901401
49Fanconi anemia pathway_Homo sapiens_hsa034600.78413237
50Butanoate metabolism_Homo sapiens_hsa006500.78261581
51One carbon pool by folate_Homo sapiens_hsa006700.76501025
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.75304309
53Pyrimidine metabolism_Homo sapiens_hsa002400.74792947
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74656422
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72633870
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71361425
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.71103724
58Retinol metabolism_Homo sapiens_hsa008300.69511216
59Purine metabolism_Homo sapiens_hsa002300.68906447
60Basal transcription factors_Homo sapiens_hsa030220.68685398
61Ether lipid metabolism_Homo sapiens_hsa005650.65964980
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.65492447
63Regulation of autophagy_Homo sapiens_hsa041400.64025735
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63696989
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63417718
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.57872174
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57586523
68Collecting duct acid secretion_Homo sapiens_hsa049660.54639794
69Herpes simplex infection_Homo sapiens_hsa051680.53774387
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53300951
71Nucleotide excision repair_Homo sapiens_hsa034200.52157439
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.50873055
73Malaria_Homo sapiens_hsa051440.46741667
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44147034
75Measles_Homo sapiens_hsa051620.43732122
76Taste transduction_Homo sapiens_hsa047420.42955785
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41972493
78Spliceosome_Homo sapiens_hsa030400.39438095
79Metabolic pathways_Homo sapiens_hsa011000.38804352
80Mismatch repair_Homo sapiens_hsa034300.37507790
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36187018
82Sulfur metabolism_Homo sapiens_hsa009200.34569259
83Fat digestion and absorption_Homo sapiens_hsa049750.33638028
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33404619
85RNA transport_Homo sapiens_hsa030130.33325070
86African trypanosomiasis_Homo sapiens_hsa051430.31298038
87Salivary secretion_Homo sapiens_hsa049700.30053180
88Nicotine addiction_Homo sapiens_hsa050330.28324504
89Base excision repair_Homo sapiens_hsa034100.28132279
90Morphine addiction_Homo sapiens_hsa050320.27416429
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25197722
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.24696167
93Epstein-Barr virus infection_Homo sapiens_hsa051690.23452651
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23244999
95DNA replication_Homo sapiens_hsa030300.22583427
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.22133410
97Legionellosis_Homo sapiens_hsa051340.21163936
98Tuberculosis_Homo sapiens_hsa051520.20623683
99Ovarian steroidogenesis_Homo sapiens_hsa049130.19397801
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17010035

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