RPL7P60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)4.87657241
2ATP synthesis coupled proton transport (GO:0015986)4.87657241
3ribosomal small subunit assembly (GO:0000028)4.74113508
4DNA deamination (GO:0045006)4.65114091
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.42983906
6protein neddylation (GO:0045116)4.25185902
7maturation of SSU-rRNA (GO:0030490)4.13676938
8behavioral response to nicotine (GO:0035095)3.91649771
9preassembly of GPI anchor in ER membrane (GO:0016254)3.88764617
10ribosomal large subunit biogenesis (GO:0042273)3.86908319
11protein complex biogenesis (GO:0070271)3.62646312
12viral transcription (GO:0019083)3.62581766
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.62087742
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60282237
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59688982
16piRNA metabolic process (GO:0034587)3.55783217
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51138691
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49541614
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49541614
20L-fucose catabolic process (GO:0042355)3.47067030
21fucose catabolic process (GO:0019317)3.47067030
22L-fucose metabolic process (GO:0042354)3.47067030
23translational termination (GO:0006415)3.45231569
24kynurenine metabolic process (GO:0070189)3.44607271
25chaperone-mediated protein transport (GO:0072321)3.39117356
26rRNA modification (GO:0000154)3.33700038
27water-soluble vitamin biosynthetic process (GO:0042364)3.30997018
28indole-containing compound catabolic process (GO:0042436)3.30048554
29indolalkylamine catabolic process (GO:0046218)3.30048554
30tryptophan catabolic process (GO:0006569)3.30048554
31mitochondrial respiratory chain complex assembly (GO:0033108)3.29600422
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28990051
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23453472
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.22414340
35NADH dehydrogenase complex assembly (GO:0010257)3.22414340
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22414340
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21599004
38protein targeting to ER (GO:0045047)3.18938151
39aldehyde catabolic process (GO:0046185)3.18828698
40electron transport chain (GO:0022900)3.17753474
41respiratory electron transport chain (GO:0022904)3.16806689
42cotranslational protein targeting to membrane (GO:0006613)3.16082984
43maturation of 5.8S rRNA (GO:0000460)3.14706156
44negative regulation of telomere maintenance (GO:0032205)3.13185835
45GPI anchor metabolic process (GO:0006505)3.12082277
46translational elongation (GO:0006414)3.12047741
47GPI anchor biosynthetic process (GO:0006506)3.09936349
48ubiquinone biosynthetic process (GO:0006744)3.08033945
49protein localization to endoplasmic reticulum (GO:0070972)3.06447065
50GTP biosynthetic process (GO:0006183)3.05660885
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01477043
52indolalkylamine metabolic process (GO:0006586)3.00726008
53response to pheromone (GO:0019236)2.96083951
54purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90064287
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88545405
56tRNA processing (GO:0008033)2.87952331
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85762721
58negative regulation of B cell apoptotic process (GO:0002903)2.84479466
59respiratory chain complex IV assembly (GO:0008535)2.83181941
60tryptophan metabolic process (GO:0006568)2.83174204
61ATP biosynthetic process (GO:0006754)2.83140517
62ribosomal small subunit biogenesis (GO:0042274)2.81111868
63cullin deneddylation (GO:0010388)2.80413029
64pseudouridine synthesis (GO:0001522)2.79264778
65hydrogen ion transmembrane transport (GO:1902600)2.76450459
66regulation of cellular amino acid metabolic process (GO:0006521)2.76145594
67mannosylation (GO:0097502)2.73637019
68protein deneddylation (GO:0000338)2.72515142
69proton transport (GO:0015992)2.72248075
70cytochrome complex assembly (GO:0017004)2.71411971
71ubiquinone metabolic process (GO:0006743)2.69854991
72hydrogen transport (GO:0006818)2.69714577
73translation (GO:0006412)2.69039069
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68228382
75negative regulation of mast cell activation (GO:0033004)2.66203267
76regulation of isotype switching to IgG isotypes (GO:0048302)2.65952098
77kidney morphogenesis (GO:0060993)2.65038459
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64257501
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64257501
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64257501
81positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.62172257
82rRNA processing (GO:0006364)2.61268995
83cellular component biogenesis (GO:0044085)2.61183945
84nonmotile primary cilium assembly (GO:0035058)2.60699222
85regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60306763
86negative regulation of T cell differentiation in thymus (GO:0033085)2.59404690
87rRNA metabolic process (GO:0016072)2.59176470
88regulation of cilium movement (GO:0003352)2.58381445
89viral life cycle (GO:0019058)2.57820773
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55872707
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55872707
92regulation of B cell apoptotic process (GO:0002902)2.55766504
93regulation of immunoglobulin secretion (GO:0051023)2.55481920
94mast cell activation involved in immune response (GO:0002279)2.54924639
95mast cell degranulation (GO:0043303)2.54924639
96cellular ketone body metabolic process (GO:0046950)2.53557152
97DNA methylation involved in gamete generation (GO:0043046)2.53185171
98negative regulation of reactive oxygen species metabolic process (GO:2000378)2.52588442
99UTP biosynthetic process (GO:0006228)2.52485037
100auditory receptor cell stereocilium organization (GO:0060088)2.48368421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01411411
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.83956200
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93013377
4ZNF274_21170338_ChIP-Seq_K562_Hela2.90702107
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80926918
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.80446874
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53239614
8IGF1R_20145208_ChIP-Seq_DFB_Human2.48651095
9VDR_22108803_ChIP-Seq_LS180_Human2.44919328
10EZH2_22144423_ChIP-Seq_EOC_Human2.37925150
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28484807
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21823166
13VDR_23849224_ChIP-Seq_CD4+_Human2.15941746
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.14163103
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.12396227
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.11996962
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93028763
18EWS_26573619_Chip-Seq_HEK293_Human1.91980022
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87302979
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85949859
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.85647261
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83681003
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78122137
24ELK1_19687146_ChIP-ChIP_HELA_Human1.75833729
25MYC_18940864_ChIP-ChIP_HL60_Human1.74254121
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68662427
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64620613
28TP53_22573176_ChIP-Seq_HFKS_Human1.64353599
29FOXP3_21729870_ChIP-Seq_TREG_Human1.63152933
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59350453
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58734535
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58711238
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.54768031
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54768031
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48579105
36FUS_26573619_Chip-Seq_HEK293_Human1.48550119
37GBX2_23144817_ChIP-Seq_PC3_Human1.48340172
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47470575
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45531979
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44339932
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.43625797
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43217655
43IRF1_19129219_ChIP-ChIP_H3396_Human1.42221893
44TAF15_26573619_Chip-Seq_HEK293_Human1.41061157
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.40107969
46AR_20517297_ChIP-Seq_VCAP_Human1.39025081
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.38406430
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37797913
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34173331
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33474563
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33352289
52ER_23166858_ChIP-Seq_MCF-7_Human1.29119750
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27796365
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27146830
55NANOG_19829295_ChIP-Seq_ESCs_Human1.27146830
56P300_19829295_ChIP-Seq_ESCs_Human1.25362202
57GATA3_26560356_Chip-Seq_TH2_Human1.24168634
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20292668
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20269905
60NCOR_22424771_ChIP-Seq_293T_Human1.18741632
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.18348574
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.17698018
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17153407
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16590884
65TAF2_19829295_ChIP-Seq_ESCs_Human1.16062090
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.15884930
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15031841
68ERA_21632823_ChIP-Seq_H3396_Human1.14815669
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13814506
70NANOG_20526341_ChIP-Seq_ESCs_Human1.12946542
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.12590179
72HOXB7_26014856_ChIP-Seq_BT474_Human1.12328758
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11431853
74CBP_20019798_ChIP-Seq_JUKART_Human1.10595030
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10595030
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08571349
77MYC_19829295_ChIP-Seq_ESCs_Human1.07644349
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06702807
79ERG_20517297_ChIP-Seq_VCAP_Human1.05186536
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04837293
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04435433
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00567698
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98549294
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97853513
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96395410
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95540101
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95338062
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94573991
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94239248
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.93117583
91TCF4_22108803_ChIP-Seq_LS180_Human0.92599997
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92296503
93P53_21459846_ChIP-Seq_SAOS-2_Human0.92072025
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91486112
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91464423
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91385236
97REST_21632747_ChIP-Seq_MESCs_Mouse0.91255956
98TTF2_22483619_ChIP-Seq_HELA_Human0.90901465
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88994875
100BCAT_22108803_ChIP-Seq_LS180_Human0.88851062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.82274377
2MP0008875_abnormal_xenobiotic_pharmacok2.95530614
3MP0006292_abnormal_olfactory_placode2.87692975
4MP0008872_abnormal_physiological_respon2.56345161
5MP0003646_muscle_fatigue2.53538864
6MP0002837_dystrophic_cardiac_calcinosis2.44311762
7MP0005646_abnormal_pituitary_gland2.43320233
8MP0001835_abnormal_antigen_presentation2.33271002
9MP0001968_abnormal_touch/_nociception2.30267520
10MP0002102_abnormal_ear_morphology2.28469789
11MP0004147_increased_porphyrin_level2.23802874
12MP0008877_abnormal_DNA_methylation2.13866807
13MP0005671_abnormal_response_to2.03696842
14MP0005645_abnormal_hypothalamus_physiol2.01777312
15MP0003787_abnormal_imprinting2.00339327
16MP0009379_abnormal_foot_pigmentation1.97632380
17MP0005084_abnormal_gallbladder_morpholo1.92544253
18MP0004885_abnormal_endolymph1.86505179
19MP0002876_abnormal_thyroid_physiology1.85679878
20MP0004142_abnormal_muscle_tone1.75784195
21MP0005075_abnormal_melanosome_morpholog1.70286880
22MP0006054_spinal_hemorrhage1.68871133
23MP0002736_abnormal_nociception_after1.66298395
24MP0005167_abnormal_blood-brain_barrier1.64758549
25MP0005551_abnormal_eye_electrophysiolog1.61159093
26MP0000372_irregular_coat_pigmentation1.60608788
27MP0001986_abnormal_taste_sensitivity1.59082707
28MP0001984_abnormal_olfaction1.57197109
29MP0003786_premature_aging1.49971239
30MP0003011_delayed_dark_adaptation1.46259872
31MP0003724_increased_susceptibility_to1.44387045
32MP0001905_abnormal_dopamine_level1.43191775
33MP0006072_abnormal_retinal_apoptosis1.40795384
34MP0003186_abnormal_redox_activity1.39372646
35MP0002733_abnormal_thermal_nociception1.39141085
36MP0002148_abnormal_hypersensitivity_rea1.39078428
37MP0002006_tumorigenesis1.35048343
38MP0008775_abnormal_heart_ventricle1.34575782
39MP0002163_abnormal_gland_morphology1.33208496
40MP0001800_abnormal_humoral_immune1.32648908
41MP0006276_abnormal_autonomic_nervous1.29499683
42MP0001529_abnormal_vocalization1.23518902
43MP0001440_abnormal_grooming_behavior1.23121140
44MP0001970_abnormal_pain_threshold1.22300994
45MP0009333_abnormal_splenocyte_physiolog1.21079938
46MP0002272_abnormal_nervous_system1.20906230
47MP0005389_reproductive_system_phenotype1.20867122
48MP0002166_altered_tumor_susceptibility1.20682718
49MP0000685_abnormal_immune_system1.20614009
50MP0000569_abnormal_digit_pigmentation1.20434193
51MP0003252_abnormal_bile_duct1.20116658
52MP0008058_abnormal_DNA_repair1.16488730
53MP0005085_abnormal_gallbladder_physiolo1.11878766
54MP0001790_abnormal_immune_system1.07767174
55MP0005387_immune_system_phenotype1.07767174
56MP0001293_anophthalmia1.06934992
57MP0001919_abnormal_reproductive_system1.05608971
58MP0003195_calcinosis1.05451588
59MP0004043_abnormal_pH_regulation1.04989110
60MP0009745_abnormal_behavioral_response1.04324891
61MP0002234_abnormal_pharynx_morphology1.03985398
62MP0000230_abnormal_systemic_arterial1.03575530
63MP0002735_abnormal_chemical_nociception1.01580722
64MP0001485_abnormal_pinna_reflex1.00027441
65MP0000631_abnormal_neuroendocrine_gland0.99859530
66MP0002638_abnormal_pupillary_reflex0.98616913
67MP0009764_decreased_sensitivity_to0.98055015
68MP0005636_abnormal_mineral_homeostasis0.97697881
69MP0005253_abnormal_eye_physiology0.97079507
70MP0005000_abnormal_immune_tolerance0.95602974
71MP0002723_abnormal_immune_serum0.94298509
72MP0008789_abnormal_olfactory_epithelium0.94241614
73MP0002160_abnormal_reproductive_system0.93883693
74MP0000427_abnormal_hair_cycle0.92874183
75MP0003718_maternal_effect0.92226315
76MP0005379_endocrine/exocrine_gland_phen0.91641717
77MP0000013_abnormal_adipose_tissue0.87658401
78MP0005332_abnormal_amino_acid0.87212005
79MP0003121_genomic_imprinting0.86839746
80MP0004133_heterotaxia0.86816791
81MP0002572_abnormal_emotion/affect_behav0.85347658
82MP0002557_abnormal_social/conspecific_i0.84004790
83MP0006036_abnormal_mitochondrial_physio0.80916398
84MP0003122_maternal_imprinting0.80638370
85MP0009046_muscle_twitch0.78301946
86MP0002452_abnormal_antigen_presenting0.78093201
87MP0002693_abnormal_pancreas_physiology0.78075814
88MP0003866_abnormal_defecation0.77553940
89MP0003878_abnormal_ear_physiology0.76508879
90MP0005377_hearing/vestibular/ear_phenot0.76508879
91MP0001764_abnormal_homeostasis0.75518020
92MP0010386_abnormal_urinary_bladder0.75364225
93MP0005360_urolithiasis0.75215560
94MP0005220_abnormal_exocrine_pancreas0.74568824
95MP0005410_abnormal_fertilization0.74392545
96MP0002420_abnormal_adaptive_immunity0.73963052
97MP0008995_early_reproductive_senescence0.73680364
98MP0001819_abnormal_immune_cell0.71926648
99MP0003567_abnormal_fetal_cardiomyocyte0.71795207
100MP0005195_abnormal_posterior_eye0.71575846

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)3.98364851
2Abnormality of midbrain morphology (HP:0002418)3.98364851
3Acute necrotizing encephalopathy (HP:0006965)3.90871419
4Pancreatic cysts (HP:0001737)3.76091538
5Mitochondrial inheritance (HP:0001427)3.66688196
6Pancreatic fibrosis (HP:0100732)3.66096621
7Type 2 muscle fiber atrophy (HP:0003554)3.57615548
8Increased CSF lactate (HP:0002490)3.48664345
9Acute encephalopathy (HP:0006846)3.41860645
10Progressive macrocephaly (HP:0004481)3.36199446
11Abnormal mitochondria in muscle tissue (HP:0008316)3.35603694
12Nephronophthisis (HP:0000090)3.33140024
13Hepatocellular necrosis (HP:0001404)3.31811328
143-Methylglutaconic aciduria (HP:0003535)3.12804743
15Lipid accumulation in hepatocytes (HP:0006561)3.09201305
16Abnormality of the renal medulla (HP:0100957)3.07342427
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.07201571
18Absent/shortened dynein arms (HP:0200106)3.07201571
19Abolished electroretinogram (ERG) (HP:0000550)3.04444948
20Increased hepatocellular lipid droplets (HP:0006565)3.03018699
21Congenital stationary night blindness (HP:0007642)2.98977103
22Abnormality of cells of the erythroid lineage (HP:0012130)2.97148247
23True hermaphroditism (HP:0010459)2.96679585
24Abnormality of alanine metabolism (HP:0010916)2.95896864
25Hyperalaninemia (HP:0003348)2.95896864
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95896864
27Muscle fiber atrophy (HP:0100295)2.93172539
28Hepatic necrosis (HP:0002605)2.88331064
29Reticulocytopenia (HP:0001896)2.80964798
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75809087
31Decreased central vision (HP:0007663)2.73744666
32Increased serum lactate (HP:0002151)2.72927399
33Elevated erythrocyte sedimentation rate (HP:0003565)2.72030410
34Congenital, generalized hypertrichosis (HP:0004540)2.68874783
35Abnormal rod and cone electroretinograms (HP:0008323)2.65253211
36Type II lissencephaly (HP:0007260)2.62751862
37Abnormality of the renal cortex (HP:0011035)2.62375010
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60929930
39Abnormal biliary tract physiology (HP:0012439)2.56269241
40Bile duct proliferation (HP:0001408)2.56269241
41Pendular nystagmus (HP:0012043)2.54750302
42Keratoconus (HP:0000563)2.54067747
43Increased corneal curvature (HP:0100692)2.54067747
44Optic disc pallor (HP:0000543)2.53759933
45Cerebral edema (HP:0002181)2.50863895
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48114378
47IgG deficiency (HP:0004315)2.42784915
48Medial flaring of the eyebrow (HP:0010747)2.42478355
49Cystic liver disease (HP:0006706)2.41303737
50Stomatitis (HP:0010280)2.38010174
51Attenuation of retinal blood vessels (HP:0007843)2.35499996
52Abnormal number of erythroid precursors (HP:0012131)2.34252521
53Hypomagnesemia (HP:0002917)2.26946981
54Lactic acidosis (HP:0003128)2.24128495
55Abnormality of the prostate (HP:0008775)2.22488293
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21003669
57Abnormal respiratory motile cilium morphology (HP:0005938)2.17150708
58Abnormal respiratory epithelium morphology (HP:0012253)2.17150708
59Polyuria (HP:0000103)2.17110968
60Supernumerary spleens (HP:0009799)2.14711980
61Testicular atrophy (HP:0000029)2.14610326
62Abnormal drinking behavior (HP:0030082)2.12987758
63Polydipsia (HP:0001959)2.12987758
64Renal Fanconi syndrome (HP:0001994)2.09680512
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.08378415
66Increased intramyocellular lipid droplets (HP:0012240)2.05443865
67Asplenia (HP:0001746)2.02888721
68Methylmalonic acidemia (HP:0002912)2.01847281
69Absent thumb (HP:0009777)2.01359099
70Sclerocornea (HP:0000647)2.00664963
71Tubulointerstitial fibrosis (HP:0005576)2.00142253
72Congenital hepatic fibrosis (HP:0002612)1.99095755
73Abnormality of the pons (HP:0007361)1.93554830
74Abnormality of magnesium homeostasis (HP:0004921)1.93427149
75Tubular atrophy (HP:0000092)1.93215530
76Respiratory failure (HP:0002878)1.92762502
77Delayed CNS myelination (HP:0002188)1.92482894
78Chronic sinusitis (HP:0011109)1.92372105
79Abnormal ciliary motility (HP:0012262)1.91539264
80Exertional dyspnea (HP:0002875)1.90319340
81Hypoproteinemia (HP:0003075)1.87571479
82Lethargy (HP:0001254)1.86740386
83Macrocytic anemia (HP:0001972)1.85669728
84Aplasia/hypoplasia of the uterus (HP:0008684)1.83909330
85Neoplasm of the adrenal cortex (HP:0100641)1.83454383
86Abnormality of B cell number (HP:0010975)1.81148565
87Abnormal urine output (HP:0012590)1.80585484
88Increased IgM level (HP:0003496)1.80061126
89Increased muscle lipid content (HP:0009058)1.79874525
90Hyperglycinemia (HP:0002154)1.79582807
91Chorioretinal atrophy (HP:0000533)1.79216570
92Abnormal respiratory motile cilium physiology (HP:0012261)1.77879366
93Exercise intolerance (HP:0003546)1.76207776
94Postaxial foot polydactyly (HP:0001830)1.76179739
95Hypoplasia of the pons (HP:0012110)1.74906873
96Anencephaly (HP:0002323)1.71864343
97Renal cortical cysts (HP:0000803)1.71351858
98Tubulointerstitial abnormality (HP:0001969)1.68803505
99Methylmalonic aciduria (HP:0012120)1.68397200
100Glycosuria (HP:0003076)1.68280535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.70571504
2TLK13.56864752
3FRK3.28786748
4MAP4K23.21577966
5NUAK13.05489944
6STK162.81447189
7ADRBK22.62183945
8TAOK32.52053194
9GRK12.40025415
10TXK2.25068965
11TIE12.11157633
12BCKDK2.06840163
13WNK42.06411582
14KIT2.02587350
15PINK11.87694281
16PHKG21.74506955
17PHKG11.74506955
18VRK21.64742163
19TEC1.54835355
20MST41.52105600
21CDK191.51590929
22BMPR1B1.49817621
23ITK1.35371683
24PIK3CA1.29459419
25DAPK21.24728715
26MAPKAPK31.22275954
27SCYL21.19374857
28MAP4K11.17005896
29MAP3K121.16634174
30DYRK21.15346037
31CSNK1G31.13028002
32OXSR11.12054120
33VRK11.11774351
34SYK1.08275060
35FES1.05227914
36CSNK1G21.02124683
37PLK21.02113041
38DAPK11.00173251
39ERBB30.93752748
40CSNK1A1L0.93217062
41CSNK1G10.91746680
42PDK20.91539212
43MAP2K60.89007133
44INSRR0.85530967
45DAPK30.83485101
46MYLK0.78893638
47RPS6KA50.78446423
48MAPK130.78092182
49BMPR20.77344896
50EIF2AK30.76402885
51PRKCQ0.76306301
52MAPKAPK50.76234221
53ADRBK10.75743457
54PLK30.75335690
55STK390.75288039
56BTK0.69949935
57FGFR20.69738315
58IKBKB0.69020899
59BCR0.66865345
60GRK50.65888501
61RIPK40.64086713
62NME10.63640035
63TRPM70.63592613
64EIF2AK10.61751317
65TSSK60.59684207
66LYN0.58877759
67EIF2AK20.57634160
68PIK3CG0.57385761
69WNK30.55687684
70PRKCG0.54873075
71PRKCE0.54853022
72FLT30.54556180
73TAF10.54366407
74TGFBR10.53949372
75MKNK10.51609482
76TRIM280.50467148
77GRK60.48224523
78CASK0.47995251
79PRKCH0.47317123
80LCK0.47243162
81PRKCI0.47223758
82MATK0.45764076
83PRKCA0.45165602
84ACVR1B0.44993301
85PRKACA0.44700738
86IGF1R0.39724726
87PTK2B0.38865727
88OBSCN0.38323525
89AURKB0.38167935
90RPS6KB20.38111157
91CAMK2A0.37959258
92CDK80.37726009
93CSNK2A20.37470014
94TNIK0.37035529
95ABL10.35681563
96CSNK1A10.35136610
97IKBKE0.34830419
98CAMK2D0.33789025
99NME20.33595668
100CSF1R0.32238799

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.87730072
2Ribosome_Homo sapiens_hsa030103.31080926
3Proteasome_Homo sapiens_hsa030503.30490358
4Oxidative phosphorylation_Homo sapiens_hsa001903.10811591
5Allograft rejection_Homo sapiens_hsa053302.94763266
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.78099161
7Autoimmune thyroid disease_Homo sapiens_hsa053202.75976530
8Parkinsons disease_Homo sapiens_hsa050122.48529920
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45479070
10Graft-versus-host disease_Homo sapiens_hsa053322.30551965
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28899558
12Type I diabetes mellitus_Homo sapiens_hsa049402.15565461
13Caffeine metabolism_Homo sapiens_hsa002322.11314877
14Protein export_Homo sapiens_hsa030602.07092358
15RNA polymerase_Homo sapiens_hsa030201.91998969
16Linoleic acid metabolism_Homo sapiens_hsa005911.73449503
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64884182
18One carbon pool by folate_Homo sapiens_hsa006701.59713663
19Phototransduction_Homo sapiens_hsa047441.58994422
20Homologous recombination_Homo sapiens_hsa034401.57757454
21RNA degradation_Homo sapiens_hsa030181.57526133
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56997448
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56147107
24Cardiac muscle contraction_Homo sapiens_hsa042601.56048561
25Alzheimers disease_Homo sapiens_hsa050101.53965107
26Huntingtons disease_Homo sapiens_hsa050161.47481077
27Nitrogen metabolism_Homo sapiens_hsa009101.39594931
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37933120
29Propanoate metabolism_Homo sapiens_hsa006401.31535285
30Antigen processing and presentation_Homo sapiens_hsa046121.30452687
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24502978
32Tryptophan metabolism_Homo sapiens_hsa003801.18194523
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15339981
34Primary immunodeficiency_Homo sapiens_hsa053401.14672768
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13102790
36Basal transcription factors_Homo sapiens_hsa030221.13090017
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10729942
38Rheumatoid arthritis_Homo sapiens_hsa053231.07838921
39Peroxisome_Homo sapiens_hsa041461.07308491
40Chemical carcinogenesis_Homo sapiens_hsa052041.06675221
41Nucleotide excision repair_Homo sapiens_hsa034201.06444380
42Fanconi anemia pathway_Homo sapiens_hsa034601.04017862
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03984425
44Butanoate metabolism_Homo sapiens_hsa006501.01595368
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99744147
46Arachidonic acid metabolism_Homo sapiens_hsa005900.98689417
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95557263
48Pyrimidine metabolism_Homo sapiens_hsa002400.93710762
49Purine metabolism_Homo sapiens_hsa002300.93361357
50Systemic lupus erythematosus_Homo sapiens_hsa053220.92869005
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90812730
52Base excision repair_Homo sapiens_hsa034100.88975476
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.87073523
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86036059
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.82721614
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.81661270
57Olfactory transduction_Homo sapiens_hsa047400.79191713
58Ether lipid metabolism_Homo sapiens_hsa005650.77368390
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76644959
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74855643
61Sulfur relay system_Homo sapiens_hsa041220.73883705
62Staphylococcus aureus infection_Homo sapiens_hsa051500.73258750
63Retinol metabolism_Homo sapiens_hsa008300.73099649
64Sulfur metabolism_Homo sapiens_hsa009200.71359767
65Mismatch repair_Homo sapiens_hsa034300.71314513
66Pyruvate metabolism_Homo sapiens_hsa006200.68520061
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68470889
68Hematopoietic cell lineage_Homo sapiens_hsa046400.68308737
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65802293
70Non-homologous end-joining_Homo sapiens_hsa034500.64319577
71Metabolic pathways_Homo sapiens_hsa011000.63684547
72Fatty acid elongation_Homo sapiens_hsa000620.63596245
73Collecting duct acid secretion_Homo sapiens_hsa049660.63238017
74RNA transport_Homo sapiens_hsa030130.62468299
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.54043832
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.52147104
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50977200
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49705467
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48049017
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47523702
81Fat digestion and absorption_Homo sapiens_hsa049750.46944661
82Viral myocarditis_Homo sapiens_hsa054160.44461837
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43909101
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42096759
85Fatty acid degradation_Homo sapiens_hsa000710.38705002
86Morphine addiction_Homo sapiens_hsa050320.37198860
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35804962
88Glutathione metabolism_Homo sapiens_hsa004800.34927127
89Ovarian steroidogenesis_Homo sapiens_hsa049130.34509336
90Selenocompound metabolism_Homo sapiens_hsa004500.34460777
91Starch and sucrose metabolism_Homo sapiens_hsa005000.33823510
92Regulation of autophagy_Homo sapiens_hsa041400.33101509
93Spliceosome_Homo sapiens_hsa030400.33065384
94Nicotine addiction_Homo sapiens_hsa050330.29563300
95Folate biosynthesis_Homo sapiens_hsa007900.28652762
96Salivary secretion_Homo sapiens_hsa049700.27432407
97Serotonergic synapse_Homo sapiens_hsa047260.27097364
98Taste transduction_Homo sapiens_hsa047420.25487432
99Leishmaniasis_Homo sapiens_hsa051400.24397805
100Fatty acid biosynthesis_Homo sapiens_hsa000610.23313430

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