ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.05555821
2	behavioral response to nicotine (GO:0035095)	4.03843120
3	positive regulation of T-helper 1 type immune response (GO:0002827)	3.98961036
4	positive regulation of prostaglandin secretion (GO:0032308)	3.67286182
5	rRNA modification (GO:0000154)	3.67142692
6	protein neddylation (GO:0045116)	3.65753211
7	preassembly of GPI anchor in ER membrane (GO:0016254)	3.62659205
8	piRNA metabolic process (GO:0034587)	3.56004716
9	L-fucose catabolic process (GO:0042355)	3.55546630
10	fucose catabolic process (GO:0019317)	3.55546630
11	L-fucose metabolic process (GO:0042354)	3.55546630
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.54933286
13	rRNA methylation (GO:0031167)	3.54412272
14	regulation of immunoglobulin secretion (GO:0051023)	3.48798467
15	cytidine metabolic process (GO:0046087)	3.35468736
16	cytidine catabolic process (GO:0006216)	3.35468736
17	cytidine deamination (GO:0009972)	3.35468736
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.29631036
19	positive regulation of defense response to virus by host (GO:0002230)	3.25074946
20	proteasome assembly (GO:0043248)	3.23789724
21	oxidative demethylation (GO:0070989)	3.19581612
22	axoneme assembly (GO:0035082)	3.18878185
23	interferon-gamma production (GO:0032609)	3.18248193
24	kynurenine metabolic process (GO:0070189)	3.13439720
25	regulation of T-helper 1 type immune response (GO:0002825)	3.09481294
26	rRNA catabolic process (GO:0016075)	3.07729156
27	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.06534603
28	ribosomal small subunit assembly (GO:0000028)	3.05884620
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.05257173
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.05257173
31	regulation of cilium movement (GO:0003352)	3.03792605
32	protein polyglutamylation (GO:0018095)	3.01185827
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98789888
34	positive regulation of fatty acid transport (GO:2000193)	2.96876340
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.96875830
36	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.95777064
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.95128249
38	ATP synthesis coupled proton transport (GO:0015986)	2.95128249
39	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.93222790
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.90259059
41	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.90149033
42	aggressive behavior (GO:0002118)	2.89638645
43	S-adenosylmethionine metabolic process (GO:0046500)	2.88680975
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.85104143
45	termination of RNA polymerase III transcription (GO:0006386)	2.85104143
46	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.84837572
47	viral transcription (GO:0019083)	2.84010283
48	translational termination (GO:0006415)	2.83147491
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82978333
50	NADH dehydrogenase complex assembly (GO:0010257)	2.82978333
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82978333
52	indolalkylamine metabolic process (GO:0006586)	2.82679909
53	auditory receptor cell stereocilium organization (GO:0060088)	2.81830202
54	negative regulation of T cell differentiation in thymus (GO:0033085)	2.81178070
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.80436325
56	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.80008202
57	DNA methylation involved in gamete generation (GO:0043046)	2.79406028
58	drug catabolic process (GO:0042737)	2.78841309
59	ribosomal large subunit biogenesis (GO:0042273)	2.78292407
60	regulation of prostaglandin secretion (GO:0032306)	2.77122147
61	GTP biosynthetic process (GO:0006183)	2.75194746
62	indole-containing compound catabolic process (GO:0042436)	2.74358221
63	indolalkylamine catabolic process (GO:0046218)	2.74358221
64	tryptophan catabolic process (GO:0006569)	2.74358221
65	amino acid salvage (GO:0043102)	2.73831167
66	L-methionine salvage (GO:0071267)	2.73831167
67	L-methionine biosynthetic process (GO:0071265)	2.73831167
68	mast cell activation involved in immune response (GO:0002279)	2.73720195
69	mast cell degranulation (GO:0043303)	2.73720195
70	tryptophan metabolic process (GO:0006568)	2.68788346
71	protein complex biogenesis (GO:0070271)	2.66880870
72	cellular response to interleukin-15 (GO:0071350)	2.66350669
73	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.62371391
74	response to nitrosative stress (GO:0051409)	2.60933037
75	response to xenobiotic stimulus (GO:0009410)	2.60822737
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.60350432
77	translational elongation (GO:0006414)	2.60241789
78	positive regulation of icosanoid secretion (GO:0032305)	2.58569271
79	RNA destabilization (GO:0050779)	2.56529927
80	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.54688269
81	nephron tubule morphogenesis (GO:0072078)	2.54168055
82	nephron epithelium morphogenesis (GO:0072088)	2.54168055
83	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52541163
84	regulation of thymocyte apoptotic process (GO:0070243)	2.52289295
85	aldehyde catabolic process (GO:0046185)	2.51952711
86	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.49670167
87	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.49016029
88	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.48049346
89	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.48049346
90	isotype switching (GO:0045190)	2.48049346
91	maturation of SSU-rRNA (GO:0030490)	2.47429402
92	glyoxylate metabolic process (GO:0046487)	2.46899810
93	multicellular organism reproduction (GO:0032504)	2.46816024
94	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.45666978
95	regulation of microtubule-based movement (GO:0060632)	2.45640118
96	parturition (GO:0007567)	2.45018012
97	cotranslational protein targeting to membrane (GO:0006613)	2.44928890
98	protein targeting to ER (GO:0045047)	2.44483432
99	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.43026029
100	branched-chain amino acid catabolic process (GO:0009083)	2.42896355

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.30059916
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03341990
3	VDR_22108803_ChIP-Seq_LS180_Human	2.85958600
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.66621638
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57073885
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42879959
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.42613105
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.39131390
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26551623
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.22286546
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.13999854
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11349376
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.06150770
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.96893730
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.87497600
16	EWS_26573619_Chip-Seq_HEK293_Human	1.84762483
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83734637
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83467355
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.77903318
20	FUS_26573619_Chip-Seq_HEK293_Human	1.70941490
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69149732
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69132581
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.69015467
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.68165471
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67233202
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65725032
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65400998
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63679053
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.62313417
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.61751892
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61139389
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.60179890
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.58786249
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.58330375
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.57863420
36	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.57363065
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.56742611
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.56742611
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53176357
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.53035477
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51740614
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50807414
43	AR_20517297_ChIP-Seq_VCAP_Human	1.48561716
44	GATA3_26560356_Chip-Seq_TH2_Human	1.43033211
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.42527997
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42527997
47	P300_19829295_ChIP-Seq_ESCs_Human	1.40939001
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40014265
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37482264
50	EZH2_22144423_ChIP-Seq_EOC_Human	1.36967754
51	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.35509129
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34548370
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33589788
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32151566
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31621112
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31621112
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27965122
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24508262
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22269034
60	NCOR_22424771_ChIP-Seq_293T_Human	1.22023662
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21715177
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21433119
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20458351
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20409072
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19430294
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18508331
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16049888
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16042567
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.14965699
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13844243
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.12389122
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11273556
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10984394
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10877833
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09448084
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08912924
77	STAT1_20625510_ChIP-Seq_HELA_Human	1.07530998
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.07327629
79	ERA_21632823_ChIP-Seq_H3396_Human	1.07155382
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06944474
81	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.06229634
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.06063025
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06005786
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03612803
85	BCAT_22108803_ChIP-Seq_LS180_Human	1.03434338
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99680525
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99116818
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98520029
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96702213
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96681276
91	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.96604196
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96443047
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96017625
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95758101
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93769753
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92352747
97	TCF4_23295773_ChIP-Seq_U87_Human	0.92057166
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.91809758
99	STAT3_23295773_ChIP-Seq_U87_Human	0.91467018
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.91198701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.63733520
2	MP0003787_abnormal_imprinting	3.15518546
3	MP0001835_abnormal_antigen_presentation	2.77820444
4	MP0003806_abnormal_nucleotide_metabolis	2.76138374
5	MP0008875_abnormal_xenobiotic_pharmacok	2.62663924
6	MP0006292_abnormal_olfactory_placode	2.62583695
7	MP0005671_abnormal_response_to	2.55673149
8	MP0004145_abnormal_muscle_electrophysio	2.53151261
9	MP0001968_abnormal_touch/_nociception	2.37142761
10	MP0008877_abnormal_DNA_methylation	2.36134164
11	MP0002653_abnormal_ependyma_morphology	2.21905679
12	MP0003195_calcinosis	2.17128664
13	MP0005645_abnormal_hypothalamus_physiol	2.12425558
14	MP0005084_abnormal_gallbladder_morpholo	2.06726447
15	MP0008872_abnormal_physiological_respon	1.98303479
16	MP0001984_abnormal_olfaction	1.92207498
17	MP0002736_abnormal_nociception_after	1.92038213
18	MP0002876_abnormal_thyroid_physiology	1.88820649
19	MP0001986_abnormal_taste_sensitivity	1.86755482
20	MP0002102_abnormal_ear_morphology	1.86263934
21	MP0004142_abnormal_muscle_tone	1.80322297
22	MP0005646_abnormal_pituitary_gland	1.74896973
23	MP0000685_abnormal_immune_system	1.73729868
24	MP0004885_abnormal_endolymph	1.71157396
25	MP0003646_muscle_fatigue	1.63655844
26	MP0006072_abnormal_retinal_apoptosis	1.63117295
27	MP0008789_abnormal_olfactory_epithelium	1.58712383
28	MP0001501_abnormal_sleep_pattern	1.55821333
29	MP0002277_abnormal_respiratory_mucosa	1.54477257
30	MP0005075_abnormal_melanosome_morpholog	1.53951181
31	MP0005387_immune_system_phenotype	1.52469324
32	MP0001790_abnormal_immune_system	1.52469324
33	MP0000427_abnormal_hair_cycle	1.49132601
34	MP0002163_abnormal_gland_morphology	1.48679921
35	MP0008775_abnormal_heart_ventricle	1.41609965
36	MP0005551_abnormal_eye_electrophysiolog	1.41580214
37	MP0001800_abnormal_humoral_immune	1.39976014
38	MP0002139_abnormal_hepatobiliary_system	1.31121510
39	MP0002272_abnormal_nervous_system	1.26721287
40	MP0006276_abnormal_autonomic_nervous	1.25322388
41	MP0005394_taste/olfaction_phenotype	1.23407823
42	MP0005499_abnormal_olfactory_system	1.23407823
43	MP0005000_abnormal_immune_tolerance	1.20025350
44	MP0003121_genomic_imprinting	1.19026924
45	MP0004742_abnormal_vestibular_system	1.18816425
46	MP0002723_abnormal_immune_serum	1.16801058
47	MP0003011_delayed_dark_adaptation	1.15698358
48	MP0003878_abnormal_ear_physiology	1.15247824
49	MP0005377_hearing/vestibular/ear_phenot	1.15247824
50	MP0009764_decreased_sensitivity_to	1.13852867
51	MP0003718_maternal_effect	1.11355188
52	MP0002006_tumorigenesis	1.10811788
53	MP0001440_abnormal_grooming_behavior	1.09368967
54	MP0002148_abnormal_hypersensitivity_rea	1.08953622
55	MP0002735_abnormal_chemical_nociception	1.08532766
56	MP0005379_endocrine/exocrine_gland_phen	1.08077149
57	MP0001529_abnormal_vocalization	1.07953357
58	MP0001873_stomach_inflammation	1.07564518
59	MP0001970_abnormal_pain_threshold	1.06894936
60	MP0002733_abnormal_thermal_nociception	1.06699342
61	MP0002928_abnormal_bile_duct	1.04445657
62	MP0003724_increased_susceptibility_to	1.01819814
63	MP0000383_abnormal_hair_follicle	0.99832828
64	MP0002166_altered_tumor_susceptibility	0.99594276
65	MP0000372_irregular_coat_pigmentation	0.98861079
66	MP0009333_abnormal_splenocyte_physiolog	0.96862710
67	MP0003252_abnormal_bile_duct	0.96557401
68	MP0005389_reproductive_system_phenotype	0.96498323
69	MP0005253_abnormal_eye_physiology	0.96113795
70	MP0001502_abnormal_circadian_rhythm	0.95315208
71	MP0009745_abnormal_behavioral_response	0.93663523
72	MP0000631_abnormal_neuroendocrine_gland	0.92937165
73	MP0005085_abnormal_gallbladder_physiolo	0.92385998
74	MP0005386_behavior/neurological_phenoty	0.92294063
75	MP0004924_abnormal_behavior	0.92294063
76	MP0002452_abnormal_antigen_presenting	0.91910615
77	MP0002837_dystrophic_cardiac_calcinosis	0.91816126
78	MP0009785_altered_susceptibility_to	0.91540546
79	MP0005365_abnormal_bile_salt	0.91313010
80	MP0001819_abnormal_immune_cell	0.90554341
81	MP0002420_abnormal_adaptive_immunity	0.87129405
82	MP0005410_abnormal_fertilization	0.86159008
83	MP0001905_abnormal_dopamine_level	0.84686271
84	MP0002234_abnormal_pharynx_morphology	0.82479776
85	MP0001663_abnormal_digestive_system	0.82062795
86	MP0003186_abnormal_redox_activity	0.79093420
87	MP0001485_abnormal_pinna_reflex	0.79075746
88	MP0000569_abnormal_digit_pigmentation	0.77960646
89	MP0003879_abnormal_hair_cell	0.77387021
90	MP0010386_abnormal_urinary_bladder	0.76398950
91	MP0003122_maternal_imprinting	0.75123064
92	MP0002160_abnormal_reproductive_system	0.74907026
93	MP0003638_abnormal_response/metabolism_	0.74859545
94	MP0006036_abnormal_mitochondrial_physio	0.74700262
95	MP0000013_abnormal_adipose_tissue	0.73754922
96	MP0009379_abnormal_foot_pigmentation	0.73670307
97	MP0002572_abnormal_emotion/affect_behav	0.73233863
98	MP0002067_abnormal_sensory_capabilities	0.71764578
99	MP0010155_abnormal_intestine_physiology	0.71597953
100	MP0000230_abnormal_systemic_arterial	0.69170420

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.64940805
2	Pancreatic cysts (HP:0001737)	4.33511365
3	Molar tooth sign on MRI (HP:0002419)	4.28762161
4	Abnormality of midbrain morphology (HP:0002418)	4.28762161
5	Type II lissencephaly (HP:0007260)	3.73867641
6	3-Methylglutaconic aciduria (HP:0003535)	3.73315877
7	Pancreatic fibrosis (HP:0100732)	3.34216046
8	Nephronophthisis (HP:0000090)	3.34028216
9	Congenital stationary night blindness (HP:0007642)	3.28572256
10	IgG deficiency (HP:0004315)	3.21677322
11	Abnormality of the renal cortex (HP:0011035)	3.20854089
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.17662404
13	Abnormality of the renal medulla (HP:0100957)	2.96181548
14	Acute necrotizing encephalopathy (HP:0006965)	2.94005916
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.86920833
16	Absent/shortened dynein arms (HP:0200106)	2.86920833
17	Cerebellar dysplasia (HP:0007033)	2.83348738
18	Chronic hepatic failure (HP:0100626)	2.77218586
19	Congenital, generalized hypertrichosis (HP:0004540)	2.71906362
20	True hermaphroditism (HP:0010459)	2.66090805
21	Acute encephalopathy (HP:0006846)	2.64098912
22	Increased CSF lactate (HP:0002490)	2.59627931
23	Cystic liver disease (HP:0006706)	2.53110385
24	Mitochondrial inheritance (HP:0001427)	2.50467673
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.49181005
26	Optic disc pallor (HP:0000543)	2.47419216
27	Methylmalonic acidemia (HP:0002912)	2.47204464
28	Abnormal biliary tract physiology (HP:0012439)	2.47090150
29	Bile duct proliferation (HP:0001408)	2.47090150
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.47053581
31	Decreased central vision (HP:0007663)	2.45415056
32	Progressive macrocephaly (HP:0004481)	2.44216210
33	Attenuation of retinal blood vessels (HP:0007843)	2.44207504
34	Abolished electroretinogram (ERG) (HP:0000550)	2.43722511
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.42996823
36	Type 2 muscle fiber atrophy (HP:0003554)	2.41266221
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39105924
38	Abnormality of alanine metabolism (HP:0010916)	2.39105924
39	Hyperalaninemia (HP:0003348)	2.39105924
40	Increased IgM level (HP:0003496)	2.36087258
41	Medial flaring of the eyebrow (HP:0010747)	2.34796124
42	Renal cortical cysts (HP:0000803)	2.33133495
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.29687144
44	Lipid accumulation in hepatocytes (HP:0006561)	2.29301375
45	Increased corneal curvature (HP:0100692)	2.28872948
46	Keratoconus (HP:0000563)	2.28872948
47	Hypoproteinemia (HP:0003075)	2.22602799
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22577997
49	Polyuria (HP:0000103)	2.18534918
50	Increased hepatocellular lipid droplets (HP:0006565)	2.17958317
51	Hypoplasia of the uterus (HP:0000013)	2.16760091
52	Thyroiditis (HP:0100646)	2.15444748
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13717754
54	Large for gestational age (HP:0001520)	2.12664593
55	Abnormality of the prostate (HP:0008775)	2.12321452
56	Polydipsia (HP:0001959)	2.11612400
57	Abnormal drinking behavior (HP:0030082)	2.11612400
58	Pendular nystagmus (HP:0012043)	2.09089705
59	Increased serum lactate (HP:0002151)	2.07568354
60	Severe combined immunodeficiency (HP:0004430)	2.04198941
61	Methylmalonic aciduria (HP:0012120)	2.00685488
62	Sclerocornea (HP:0000647)	1.99357404
63	Abnormality of macular pigmentation (HP:0008002)	1.98448461
64	Asplenia (HP:0001746)	1.96154835
65	Cerebral edema (HP:0002181)	1.95329904
66	Adrenal hypoplasia (HP:0000835)	1.94885593
67	Metabolic alkalosis (HP:0200114)	1.94759041
68	Broad alveolar ridges (HP:0000187)	1.94385161
69	Abnormality of eosinophils (HP:0001879)	1.94240075
70	Abnormality of the labia minora (HP:0012880)	1.92111006
71	Hyperglycinemia (HP:0002154)	1.91640413
72	Hyperglycinuria (HP:0003108)	1.90544918
73	Chronic mucocutaneous candidiasis (HP:0002728)	1.87910537
74	Recurrent cutaneous fungal infections (HP:0011370)	1.87910537
75	Tubular atrophy (HP:0000092)	1.86182634
76	Muscle fiber atrophy (HP:0100295)	1.84527957
77	Thyroid-stimulating hormone excess (HP:0002925)	1.84527439
78	Lethargy (HP:0001254)	1.84431618
79	Panhypogammaglobulinemia (HP:0003139)	1.84340066
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.82032236
81	Abnormality of T cells (HP:0002843)	1.81493047
82	Hypomagnesemia (HP:0002917)	1.81363500
83	Hypokalemic alkalosis (HP:0001949)	1.80295284
84	Abnormal urine output (HP:0012590)	1.79715493
85	Alkalosis (HP:0001948)	1.79167935
86	Abnormality of T cell physiology (HP:0011840)	1.77477430
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.76473510
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76473510
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.76169036
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.73975281
91	Central scotoma (HP:0000603)	1.73782263
92	Congenital hepatic fibrosis (HP:0002612)	1.73085580
93	Renal Fanconi syndrome (HP:0001994)	1.72570828
94	Abnormality of serum amino acid levels (HP:0003112)	1.72192711
95	Abnormal number of erythroid precursors (HP:0012131)	1.69579704
96	Clumsiness (HP:0002312)	1.65010072
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.63295447
98	Optic nerve coloboma (HP:0000588)	1.62818086
99	Reticulocytopenia (HP:0001896)	1.62630293
100	Lissencephaly (HP:0001339)	1.60224848

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	4.01804092
2	MAP4K2	3.48863857
3	BMPR1B	3.20181666
4	BCKDK	3.15173227
5	ADRBK2	2.85665080
6	TAOK3	2.84201462
7	FRK	2.70224823
8	STK16	2.58035155
9	TXK	2.39828053
10	ZAK	2.34040533
11	GRK1	2.31753582
12	TLK1	2.20189527
13	MST4	2.11756496
14	VRK2	2.00883218
15	TIE1	1.97150319
16	TEC	1.91413777
17	IKBKB	1.89193203
18	WNK4	1.80650204
19	EIF2AK3	1.62308643
20	DYRK2	1.60528982
21	ITK	1.52306783
22	TGFBR1	1.51909903
23	KIT	1.49900304
24	CAMKK2	1.33123155
25	OXSR1	1.30099847
26	CDK19	1.27591670
27	TNIK	1.27025607
28	RPS6KA5	1.22708308
29	FES	1.22662131
30	PIK3CG	1.21600621
31	TSSK6	1.20463321
32	IKBKE	1.17219252
33	EPHA3	1.16589174
34	PINK1	1.14827091
35	PIK3CA	1.14371371
36	TAF1	1.06231461
37	VRK1	1.01286595
38	MAP3K12	0.99492259
39	NLK	0.95295542
40	MAPKAPK5	0.93621377
41	NME1	0.93396871
42	PRKCQ	0.89466080
43	ADRBK1	0.87462605
44	MAP4K1	0.86855382
45	EIF2AK2	0.85021081
46	SYK	0.83059864
47	MAPKAPK3	0.82458678
48	PRKCE	0.82202248
49	MKNK1	0.74431115
50	MAPK13	0.74257853
51	BTK	0.73849710
52	RPS6KA4	0.70561457
53	CSF1R	0.68551102
54	PHKG2	0.68129790
55	PHKG1	0.68129790
56	MYLK	0.67725703
57	MUSK	0.67514863
58	CHUK	0.66604657
59	CSNK1G2	0.64878228
60	OBSCN	0.63536531
61	AKT3	0.63516625
62	MAP3K14	0.63315872
63	PLK2	0.61764151
64	PASK	0.61615032
65	CDK8	0.60690357
66	PLK3	0.59454509
67	SRPK1	0.59106904
68	CSNK1G3	0.57394855
69	HIPK2	0.56711617
70	IRAK1	0.56030409
71	INSRR	0.55292030
72	PDK2	0.54323885
73	FLT3	0.52759444
74	WNK3	0.51603118
75	GRK5	0.50918681
76	PRKCG	0.50536410
77	GRK6	0.48891335
78	LYN	0.48256700
79	LCK	0.47646112
80	SGK2	0.47146613
81	GRK7	0.44813675
82	WNK1	0.44522738
83	PRKCH	0.43189413
84	CSNK1A1L	0.41799303
85	TBK1	0.41463391
86	STK39	0.40483962
87	MAP2K6	0.40033561
88	CAMK1	0.39663107
89	CSNK1G1	0.37226566
90	DAPK2	0.36186300
91	PRKACA	0.35824444
92	DAPK3	0.35822909
93	RPS6KB2	0.35681910
94	MAP2K2	0.35425332
95	DAPK1	0.34982976
96	MAP3K13	0.32794465
97	RPS6KA6	0.32521872
98	PRKCA	0.32384252
99	TNK2	0.32063728
100	PAK3	0.31844595

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.94854611
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.52365979
3	Allograft rejection_Homo sapiens_hsa05330	3.47640997
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.18418405
5	Ribosome_Homo sapiens_hsa03010	2.66934200
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.35440547
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30030662
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28200191
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.24366089
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.23373365
11	RNA polymerase_Homo sapiens_hsa03020	2.08217692
12	One carbon pool by folate_Homo sapiens_hsa00670	2.01791099
13	Proteasome_Homo sapiens_hsa03050	1.96704982
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95516415
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.93575995
16	Propanoate metabolism_Homo sapiens_hsa00640	1.93390283
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88584492
18	Protein export_Homo sapiens_hsa03060	1.72856445
19	Phototransduction_Homo sapiens_hsa04744	1.64410585
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62403062
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.59415020
22	Parkinsons disease_Homo sapiens_hsa05012	1.55405344
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50450595
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49182692
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.47459826
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40780580
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.35543274
28	RNA degradation_Homo sapiens_hsa03018	1.28760327
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28727843
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.27345087
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.26164656
32	Butanoate metabolism_Homo sapiens_hsa00650	1.25206327
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18427713
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.17107162
35	Caffeine metabolism_Homo sapiens_hsa00232	1.14739546
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12391902
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12203895
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07297957
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04650566
40	Peroxisome_Homo sapiens_hsa04146	1.04170386
41	Retinol metabolism_Homo sapiens_hsa00830	1.03772445
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03484208
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02256357
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01827471
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99025712
46	Huntingtons disease_Homo sapiens_hsa05016	0.98011910
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93296181
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92525913
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88472711
50	Olfactory transduction_Homo sapiens_hsa04740	0.87134398
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87023963
52	Homologous recombination_Homo sapiens_hsa03440	0.85869616
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.85639388
54	Viral myocarditis_Homo sapiens_hsa05416	0.82899294
55	Alzheimers disease_Homo sapiens_hsa05010	0.81779110
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81420454
57	Purine metabolism_Homo sapiens_hsa00230	0.80667821
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80412096
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80069881
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79942507
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79306286
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78316195
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74556150
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.74189073
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73017067
66	Sulfur metabolism_Homo sapiens_hsa00920	0.71185658
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70351104
68	Basal transcription factors_Homo sapiens_hsa03022	0.69960041
69	Taste transduction_Homo sapiens_hsa04742	0.67595501
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64341677
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64088966
72	Sulfur relay system_Homo sapiens_hsa04122	0.63113831
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.61607884
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60107073
75	Regulation of autophagy_Homo sapiens_hsa04140	0.58755144
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54814031
77	Leishmaniasis_Homo sapiens_hsa05140	0.53404508
78	RNA transport_Homo sapiens_hsa03013	0.49661080
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49545699
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.48806025
81	Metabolic pathways_Homo sapiens_hsa01100	0.48260014
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47777769
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47746063
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47730476
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47467511
86	Fatty acid elongation_Homo sapiens_hsa00062	0.46872405
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46592011
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46503908
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45240478
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43796494
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41710800
92	Nicotine addiction_Homo sapiens_hsa05033	0.40534524
93	ABC transporters_Homo sapiens_hsa02010	0.39816860
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39800198
95	Salivary secretion_Homo sapiens_hsa04970	0.37311586
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.36928028
97	Fatty acid degradation_Homo sapiens_hsa00071	0.36772962
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.35228682
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31814548
100	Serotonergic synapse_Homo sapiens_hsa04726	0.30594391

RPL7P61

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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