ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.82528960
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.31135731
3	cytidine deamination (GO:0009972)	6.25254058
4	cytidine metabolic process (GO:0046087)	6.25254058
5	cytidine catabolic process (GO:0006216)	6.25254058
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.44269704
7	response to pheromone (GO:0019236)	5.24350412
8	ribosomal small subunit assembly (GO:0000028)	4.75836260
9	sequestering of actin monomers (GO:0042989)	4.00747576
10	behavioral response to nicotine (GO:0035095)	3.78525403
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.61768050
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59514361
13	ATP synthesis coupled proton transport (GO:0015986)	3.59514361
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.55961384
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.55961384
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.39123456
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.37114124
18	protein neddylation (GO:0045116)	3.29814632
19	kynurenine metabolic process (GO:0070189)	3.27154187
20	maturation of SSU-rRNA (GO:0030490)	3.25528457
21	positive regulation of respiratory burst (GO:0060267)	3.24075253
22	negative regulation of T cell apoptotic process (GO:0070233)	3.16426688
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.15453961
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15215645
25	axoneme assembly (GO:0035082)	3.12667169
26	indole-containing compound catabolic process (GO:0042436)	3.11149736
27	indolalkylamine catabolic process (GO:0046218)	3.11149736
28	tryptophan catabolic process (GO:0006569)	3.11149736
29	platelet dense granule organization (GO:0060155)	3.08579469
30	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.08359576
31	electron transport chain (GO:0022900)	3.04062492
32	actin nucleation (GO:0045010)	3.03478933
33	respiratory electron transport chain (GO:0022904)	3.03130076
34	DNA demethylation (GO:0080111)	3.00654719
35	iron-sulfur cluster assembly (GO:0016226)	2.98447505
36	metallo-sulfur cluster assembly (GO:0031163)	2.98447505
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97892989
38	regulation of activation of Janus kinase activity (GO:0010533)	2.96404009
39	pyrimidine nucleoside catabolic process (GO:0046135)	2.93461205
40	regulation of regulatory T cell differentiation (GO:0045589)	2.90215726
41	positive T cell selection (GO:0043368)	2.90091099
42	protein complex biogenesis (GO:0070271)	2.88286758
43	positive regulation of defense response to virus by host (GO:0002230)	2.85334626
44	negative regulation of mast cell activation (GO:0033004)	2.85271013
45	mannosylation (GO:0097502)	2.84908911
46	viral transcription (GO:0019083)	2.83726236
47	indolalkylamine metabolic process (GO:0006586)	2.83523377
48	positive regulation of calcium-mediated signaling (GO:0050850)	2.78351127
49	negative regulation by host of viral transcription (GO:0043922)	2.76952553
50	DNA dealkylation (GO:0035510)	2.76349236
51	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.76139788
52	translational termination (GO:0006415)	2.75344018
53	negative regulation of viral genome replication (GO:0045071)	2.69418254
54	response to interferon-beta (GO:0035456)	2.67464046
55	endoderm formation (GO:0001706)	2.65667522
56	cytolysis (GO:0019835)	2.65553647
57	positive thymic T cell selection (GO:0045059)	2.65331365
58	piRNA metabolic process (GO:0034587)	2.64679217
59	positive regulation of interleukin-8 secretion (GO:2000484)	2.64514054
60	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.64355296
61	protein polyglutamylation (GO:0018095)	2.63846430
62	cotranslational protein targeting to membrane (GO:0006613)	2.62104179
63	translational elongation (GO:0006414)	2.62037141
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.61114138
65	cellular biogenic amine catabolic process (GO:0042402)	2.60196864
66	amine catabolic process (GO:0009310)	2.60196864
67	protein targeting to ER (GO:0045047)	2.58343602
68	negative T cell selection (GO:0043383)	2.56391738
69	tryptophan metabolic process (GO:0006568)	2.55285484
70	negative regulation of telomere maintenance (GO:0032205)	2.54877946
71	pyrimidine-containing compound catabolic process (GO:0072529)	2.53273181
72	termination of RNA polymerase III transcription (GO:0006386)	2.51469882
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.51469882
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50522464
75	regulation of chronic inflammatory response (GO:0002676)	2.48937293
76	protein localization to endoplasmic reticulum (GO:0070972)	2.48904691
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48731558
78	NADH dehydrogenase complex assembly (GO:0010257)	2.48731558
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48731558
80	ovulation cycle (GO:0042698)	2.48708346
81	adaptation of signaling pathway (GO:0023058)	2.46873519
82	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.46050515
83	regulation of cellular amino acid metabolic process (GO:0006521)	2.46001656
84	regulation of interleukin-8 secretion (GO:2000482)	2.44835488
85	aggressive behavior (GO:0002118)	2.42937012
86	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.42759540
87	proton transport (GO:0015992)	2.40735899
88	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.39884437
89	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.39873499
90	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.38796239
91	negative regulation of T cell differentiation in thymus (GO:0033085)	2.38715085
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.38367717
93	GPI anchor metabolic process (GO:0006505)	2.38156148
94	S-adenosylmethionine metabolic process (GO:0046500)	2.37518525
95	hydrogen ion transmembrane transport (GO:1902600)	2.35775757
96	positive regulation of T cell apoptotic process (GO:0070234)	2.35708124
97	cytochrome complex assembly (GO:0017004)	2.35523592
98	hydrogen transport (GO:0006818)	2.34658657
99	rRNA catabolic process (GO:0016075)	2.34053759
100	T cell migration (GO:0072678)	2.33893034

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.83511448
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.34160564
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16387847
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.91797876
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.90086587
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79083482
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.68618750
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51670586
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.37577883
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27057800
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.18081831
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.18024142
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09144520
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.07604800
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93229171
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90910851
17	EWS_26573619_Chip-Seq_HEK293_Human	1.78795518
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.78313236
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75820125
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.74072504
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73884063
22	FUS_26573619_Chip-Seq_HEK293_Human	1.69976551
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.65560793
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64664584
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.63947079
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63686569
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.61293429
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.60271627
29	P300_19829295_ChIP-Seq_ESCs_Human	1.60059750
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58168189
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.58011759
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.56676440
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55498380
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53921733
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52755178
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.50866983
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47361201
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46990615
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.45131906
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.43593450
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43125871
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.43125871
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42754600
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.41950404
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39257308
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39243142
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39243142
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33227309
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32591542
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32591542
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31925072
52	AR_20517297_ChIP-Seq_VCAP_Human	1.31237032
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31230269
54	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31061386
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30176319
56	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.29290193
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.29193343
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27820649
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.27453296
60	NCOR_22424771_ChIP-Seq_293T_Human	1.25881081
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24057674
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21872746
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21656988
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20868605
65	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20663699
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19965840
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19516363
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19047975
69	GATA3_26560356_Chip-Seq_TH2_Human	1.17975697
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17769933
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17591801
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17430736
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14141450
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.13649676
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13615361
76	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12390399
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11889777
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11630073
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.11129485
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.09032035
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08325218
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.07576538
83	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06188975
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05478963
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05309743
86	MYB_26560356_Chip-Seq_TH2_Human	1.05260103
87	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05137283
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02624079
89	MYC_19829295_ChIP-Seq_ESCs_Human	1.02331022
90	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01641903
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01441668
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00919078
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99436836
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98442504
95	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.98335958
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96856067
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96473621
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92731390
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92240107
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92125953

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.80373070
2	MP0006292_abnormal_olfactory_placode	2.72931107
3	MP0003646_muscle_fatigue	2.54143884
4	MP0003880_abnormal_central_pattern	2.48394254
5	MP0005084_abnormal_gallbladder_morpholo	2.43852297
6	MP0009379_abnormal_foot_pigmentation	2.33820287
7	MP0005646_abnormal_pituitary_gland	2.31928624
8	MP0006072_abnormal_retinal_apoptosis	2.21520680
9	MP0001968_abnormal_touch/_nociception	2.12326084
10	MP0008877_abnormal_DNA_methylation	2.02277288
11	MP0009785_altered_susceptibility_to	2.01730274
12	MP0002736_abnormal_nociception_after	1.99977394
13	MP0004147_increased_porphyrin_level	1.99820977
14	MP0002837_dystrophic_cardiac_calcinosis	1.93024430
15	MP0001835_abnormal_antigen_presentation	1.92490368
16	MP0005551_abnormal_eye_electrophysiolog	1.87283147
17	MP0004885_abnormal_endolymph	1.87172120
18	MP0003787_abnormal_imprinting	1.78472804
19	MP0002138_abnormal_hepatobiliary_system	1.72897642
20	MP0002102_abnormal_ear_morphology	1.72839374
21	MP0008872_abnormal_physiological_respon	1.72820061
22	MP0002876_abnormal_thyroid_physiology	1.70643093
23	MP0005645_abnormal_hypothalamus_physiol	1.61928877
24	MP0008875_abnormal_xenobiotic_pharmacok	1.56828240
25	MP0001986_abnormal_taste_sensitivity	1.56419537
26	MP0004142_abnormal_muscle_tone	1.55065878
27	MP0003011_delayed_dark_adaptation	1.53646652
28	MP0005253_abnormal_eye_physiology	1.49786340
29	MP0006276_abnormal_autonomic_nervous	1.49033512
30	MP0001529_abnormal_vocalization	1.48672374
31	MP0001873_stomach_inflammation	1.41964866
32	MP0003763_abnormal_thymus_physiology	1.41235570
33	MP0001984_abnormal_olfaction	1.40681704
34	MP0001905_abnormal_dopamine_level	1.40681484
35	MP0002163_abnormal_gland_morphology	1.38366245
36	MP0005389_reproductive_system_phenotype	1.35174143
37	MP0002272_abnormal_nervous_system	1.34206294
38	MP0001919_abnormal_reproductive_system	1.34178561
39	MP0002653_abnormal_ependyma_morphology	1.33557396
40	MP0002234_abnormal_pharynx_morphology	1.32076733
41	MP0009333_abnormal_splenocyte_physiolog	1.31787959
42	MP0002638_abnormal_pupillary_reflex	1.30854686
43	MP0001485_abnormal_pinna_reflex	1.29705042
44	MP0001800_abnormal_humoral_immune	1.28865706
45	MP0005377_hearing/vestibular/ear_phenot	1.28052464
46	MP0003878_abnormal_ear_physiology	1.28052464
47	MP0009745_abnormal_behavioral_response	1.26852697
48	MP0004145_abnormal_muscle_electrophysio	1.26749246
49	MP0002160_abnormal_reproductive_system	1.21530483
50	MP0003866_abnormal_defecation	1.21175718
51	MP0008789_abnormal_olfactory_epithelium	1.21015128
52	MP0005000_abnormal_immune_tolerance	1.19889599
53	MP0002148_abnormal_hypersensitivity_rea	1.18388115
54	MP0002733_abnormal_thermal_nociception	1.17768759
55	MP0000372_irregular_coat_pigmentation	1.17256937
56	MP0005423_abnormal_somatic_nervous	1.16155850
57	MP0001970_abnormal_pain_threshold	1.15710996
58	MP0000631_abnormal_neuroendocrine_gland	1.15643353
59	MP0002723_abnormal_immune_serum	1.10740046
60	MP0000685_abnormal_immune_system	1.09970385
61	MP0001486_abnormal_startle_reflex	1.08984617
62	MP0002420_abnormal_adaptive_immunity	1.03400266
63	MP0009764_decreased_sensitivity_to	1.02765130
64	MP0001501_abnormal_sleep_pattern	1.02265772
65	MP0006082_CNS_inflammation	1.01232586
66	MP0000613_abnormal_salivary_gland	1.01212634
67	MP0001819_abnormal_immune_cell	1.00329432
68	MP0002166_altered_tumor_susceptibility	0.99335497
69	MP0003137_abnormal_impulse_conducting	0.99066926
70	MP0003567_abnormal_fetal_cardiomyocyte	0.98043029
71	MP0005410_abnormal_fertilization	0.96709008
72	MP0003195_calcinosis	0.95765281
73	MP0003122_maternal_imprinting	0.95497966
74	MP0001440_abnormal_grooming_behavior	0.93901062
75	MP0005195_abnormal_posterior_eye	0.93812951
76	MP0000049_abnormal_middle_ear	0.93399367
77	MP0002735_abnormal_chemical_nociception	0.92552258
78	MP0005025_abnormal_response_to	0.90936717
79	MP0001790_abnormal_immune_system	0.90063265
80	MP0005387_immune_system_phenotype	0.90063265
81	MP0004742_abnormal_vestibular_system	0.86669179
82	MP0001963_abnormal_hearing_physiology	0.84258334
83	MP0002752_abnormal_somatic_nervous	0.84241190
84	MP0005379_endocrine/exocrine_gland_phen	0.83638094
85	MP0002095_abnormal_skin_pigmentation	0.81224880
86	MP0002006_tumorigenesis	0.79820534
87	MP0010386_abnormal_urinary_bladder	0.79776544
88	MP0002452_abnormal_antigen_presenting	0.77791091
89	MP0002693_abnormal_pancreas_physiology	0.77360109
90	MP0002572_abnormal_emotion/affect_behav	0.77111385
91	MP0000716_abnormal_immune_system	0.76980720
92	MP0005394_taste/olfaction_phenotype	0.76843485
93	MP0005499_abnormal_olfactory_system	0.76843485
94	MP0010155_abnormal_intestine_physiology	0.74847305
95	MP0001293_anophthalmia	0.72839162
96	MP0008995_early_reproductive_senescence	0.71287841
97	MP0001764_abnormal_homeostasis	0.71048132
98	MP0000026_abnormal_inner_ear	0.70560932
99	MP0005636_abnormal_mineral_homeostasis	0.69692293
100	MP0001845_abnormal_inflammatory_respons	0.69578548

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.99137953
2	Aplastic anemia (HP:0001915)	3.79992649
3	Molar tooth sign on MRI (HP:0002419)	3.78395973
4	Abnormality of midbrain morphology (HP:0002418)	3.78395973
5	Pancreatic cysts (HP:0001737)	3.64417043
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.43707658
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.43498748
8	Pancreatic fibrosis (HP:0100732)	3.41248223
9	Acute necrotizing encephalopathy (HP:0006965)	3.39054664
10	IgG deficiency (HP:0004315)	3.37541686
11	Mitochondrial inheritance (HP:0001427)	3.34407544
12	Hypoproteinemia (HP:0003075)	3.34156960
13	True hermaphroditism (HP:0010459)	3.22962191
14	3-Methylglutaconic aciduria (HP:0003535)	3.06812393
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.04930169
16	Abolished electroretinogram (ERG) (HP:0000550)	2.99545509
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.99435630
18	Nephronophthisis (HP:0000090)	2.88999423
19	Methylmalonic acidemia (HP:0002912)	2.86927062
20	Increased CSF lactate (HP:0002490)	2.85201441
21	Severe combined immunodeficiency (HP:0004430)	2.83950835
22	Progressive macrocephaly (HP:0004481)	2.81694173
23	Congenital, generalized hypertrichosis (HP:0004540)	2.80785470
24	Acute encephalopathy (HP:0006846)	2.80052609
25	Medial flaring of the eyebrow (HP:0010747)	2.77651261
26	Hepatocellular necrosis (HP:0001404)	2.73133992
27	Attenuation of retinal blood vessels (HP:0007843)	2.63498366
28	Abnormality of B cell number (HP:0010975)	2.59679178
29	Abnormality of T cell number (HP:0011839)	2.58424939
30	Thyroiditis (HP:0100646)	2.55733973
31	Increased hepatocellular lipid droplets (HP:0006565)	2.55469766
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.53932218
33	Abnormality of the renal cortex (HP:0011035)	2.53845759
34	T lymphocytopenia (HP:0005403)	2.53325483
35	Pendular nystagmus (HP:0012043)	2.51548206
36	Hepatic necrosis (HP:0002605)	2.48141714
37	Asplenia (HP:0001746)	2.47242969
38	Methylmalonic aciduria (HP:0012120)	2.46925783
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.46026225
40	Increased intramyocellular lipid droplets (HP:0012240)	2.45586313
41	Type II lissencephaly (HP:0007260)	2.45481458
42	Abnormality of the renal medulla (HP:0100957)	2.42949143
43	Lipid accumulation in hepatocytes (HP:0006561)	2.40620469
44	Optic disc pallor (HP:0000543)	2.39327288
45	Cerebral edema (HP:0002181)	2.38118635
46	Decreased central vision (HP:0007663)	2.34477888
47	Reticulocytopenia (HP:0001896)	2.33537261
48	Renal cortical cysts (HP:0000803)	2.31858174
49	Stenosis of the external auditory canal (HP:0000402)	2.29950340
50	Polydipsia (HP:0001959)	2.29284926
51	Abnormal drinking behavior (HP:0030082)	2.29284926
52	Cystic liver disease (HP:0006706)	2.28860039
53	Stomatitis (HP:0010280)	2.24991173
54	Ketosis (HP:0001946)	2.20581560
55	Abnormality of the prostate (HP:0008775)	2.19871505
56	Increased IgM level (HP:0003496)	2.18986076
57	Autoimmune hemolytic anemia (HP:0001890)	2.16389891
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10935903
59	Absent/shortened dynein arms (HP:0200106)	2.10935903
60	Sclerocornea (HP:0000647)	2.09345969
61	B lymphocytopenia (HP:0010976)	2.08489181
62	Increased corneal curvature (HP:0100692)	2.07956877
63	Keratoconus (HP:0000563)	2.07956877
64	Chronic hepatic failure (HP:0100626)	2.05198929
65	Hyperglycinemia (HP:0002154)	2.05139508
66	Pancytopenia (HP:0001876)	2.04169374
67	Renal Fanconi syndrome (HP:0001994)	2.03744097
68	Combined immunodeficiency (HP:0005387)	2.03171758
69	Gait imbalance (HP:0002141)	2.01995676
70	Abnormality of T cells (HP:0002843)	2.01568884
71	Congenital primary aphakia (HP:0007707)	2.01525393
72	Type 2 muscle fiber atrophy (HP:0003554)	2.00435719
73	Increased muscle lipid content (HP:0009058)	1.99853491
74	Absent thumb (HP:0009777)	1.92996117
75	Nephrogenic diabetes insipidus (HP:0009806)	1.92540764
76	Increased serum lactate (HP:0002151)	1.92522848
77	Septo-optic dysplasia (HP:0100842)	1.92145788
78	Polyuria (HP:0000103)	1.91076790
79	Abnormality of cells of the erythroid lineage (HP:0012130)	1.87772526
80	Lethargy (HP:0001254)	1.87404760
81	Lactic acidosis (HP:0003128)	1.83348597
82	Congenital hepatic fibrosis (HP:0002612)	1.82857540
83	Postaxial foot polydactyly (HP:0001830)	1.82654926
84	Abnormality of eosinophils (HP:0001879)	1.82107203
85	Bile duct proliferation (HP:0001408)	1.81798943
86	Abnormal biliary tract physiology (HP:0012439)	1.81798943
87	Colon cancer (HP:0003003)	1.80833055
88	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80626546
89	Retinal dysplasia (HP:0007973)	1.80281911
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78096198
91	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.77558357
92	Dicarboxylic aciduria (HP:0003215)	1.77558357
93	Anencephaly (HP:0002323)	1.77112209
94	Type I transferrin isoform profile (HP:0003642)	1.76968369
95	Supernumerary spleens (HP:0009799)	1.76236619
96	Constricted visual fields (HP:0001133)	1.74507232
97	Ketoacidosis (HP:0001993)	1.70788970
98	Postaxial hand polydactyly (HP:0001162)	1.70747096
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.70534549
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.70382043

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.36594553
2	BCKDK	4.08975999
3	TXK	3.93936822
4	KDR	3.52814882
5	ADRBK2	2.77505863
6	MAP4K2	2.75017695
7	TESK2	2.65606127
8	FRK	2.39688430
9	GRK1	2.38758014
10	TAOK3	2.23981442
11	CDK19	2.10281503
12	ZAK	2.09655199
13	NUAK1	2.05433818
14	PINK1	1.80633738
15	TIE1	1.65338456
16	ITK	1.62310344
17	WNK3	1.60479260
18	EIF2AK3	1.44924275
19	STK16	1.44753591
20	WNK4	1.44089566
21	TLK1	1.42099166
22	VRK2	1.41979040
23	BMPR1B	1.39970530
24	TEC	1.37062548
25	MAP4K1	1.36251875
26	FES	1.31850009
27	PIK3CA	1.30716793
28	LIMK1	1.29715722
29	MAPK13	1.29195035
30	VRK1	1.25371542
31	MAP3K4	1.10281096
32	PRKCQ	1.08805636
33	SYK	1.07133005
34	MUSK	1.03146295
35	PASK	1.00439694
36	GRK7	1.00075448
37	DYRK2	0.96064463
38	CAMKK2	0.92906852
39	OXSR1	0.90512926
40	TRIM28	0.88817897
41	MAP2K7	0.87306112
42	LCK	0.81157585
43	LYN	0.78891871
44	ERBB3	0.76701836
45	GRK6	0.75273136
46	RPS6KA5	0.74939207
47	DAPK2	0.74696775
48	ADRBK1	0.73337192
49	CSNK1G1	0.73274300
50	KIT	0.72717383
51	BTK	0.70582315
52	IKBKB	0.70556341
53	CSNK1G2	0.69123002
54	PRKCE	0.69115028
55	OBSCN	0.68662833
56	PLK2	0.67501087
57	TNK2	0.65987889
58	STK39	0.65381150
59	CSNK1G3	0.64803699
60	IKBKE	0.62372760
61	RPS6KA4	0.60683862
62	EPHA4	0.59231341
63	PRKCG	0.58645780
64	MAP2K6	0.58131540
65	CSF1R	0.57813115
66	PAK3	0.54725349
67	IGF1R	0.54439305
68	PRKACA	0.54414749
69	MAP3K12	0.52952195
70	PLK4	0.52727374
71	DAPK1	0.51472547
72	PRKCA	0.49789974
73	CSNK1A1L	0.49688469
74	CSK	0.47420296
75	CAMK2A	0.46445398
76	CAMKK1	0.45717834
77	MST4	0.45456141
78	MAPKAPK3	0.45199272
79	PHKG1	0.45050827
80	PHKG2	0.45050827
81	BCR	0.44285640
82	GRK5	0.43444598
83	PIM1	0.42165409
84	NTRK2	0.41176740
85	CAMK1	0.40776285
86	NME1	0.39279310
87	MYLK	0.38570258
88	TGFBR1	0.36321827
89	CSNK1A1	0.34316600
90	MAP3K11	0.33961639
91	DAPK3	0.33865758
92	ROCK1	0.33740678
93	TESK1	0.33628733
94	INSR	0.32533746
95	CDK8	0.32298252
96	MAPKAPK5	0.31863891
97	MINK1	0.31068281
98	MKNK1	0.30978477
99	CSNK2A1	0.30201126
100	ATR	0.28705581

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.83880260
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.42551794
3	Proteasome_Homo sapiens_hsa03050	3.31726909
4	Ribosome_Homo sapiens_hsa03010	3.11946704
5	Parkinsons disease_Homo sapiens_hsa05012	2.74783407
6	Protein export_Homo sapiens_hsa03060	2.34890921
7	RNA polymerase_Homo sapiens_hsa03020	2.31981725
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.08094056
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07657495
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.04767556
11	Phototransduction_Homo sapiens_hsa04744	2.01806748
12	Allograft rejection_Homo sapiens_hsa05330	1.97574924
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.86915535
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.85426738
15	Alzheimers disease_Homo sapiens_hsa05010	1.82620118
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81478547
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.77093602
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.72710996
19	Caffeine metabolism_Homo sapiens_hsa00232	1.70561960
20	Asthma_Homo sapiens_hsa05310	1.67317124
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67290199
22	Huntingtons disease_Homo sapiens_hsa05016	1.66591545
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65991029
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64708768
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.62359558
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57578860
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56493751
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.49950102
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48660357
30	RNA degradation_Homo sapiens_hsa03018	1.46046815
31	Propanoate metabolism_Homo sapiens_hsa00640	1.29961638
32	Butanoate metabolism_Homo sapiens_hsa00650	1.27544939
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25328207
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24407068
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.17692762
36	Peroxisome_Homo sapiens_hsa04146	1.16916143
37	Olfactory transduction_Homo sapiens_hsa04740	1.15513972
38	Nicotine addiction_Homo sapiens_hsa05033	1.11552728
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.09636943
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09423961
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.05636034
42	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.04026613
43	Retinol metabolism_Homo sapiens_hsa00830	1.02877971
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97923711
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97099928
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95633376
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94597662
48	Homologous recombination_Homo sapiens_hsa03440	0.94035757
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93459749
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92387586
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.91119514
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85149399
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.79444178
54	Purine metabolism_Homo sapiens_hsa00230	0.78949419
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78665447
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78250792
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77594485
58	Basal transcription factors_Homo sapiens_hsa03022	0.77140929
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75241659
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73400230
61	Morphine addiction_Homo sapiens_hsa05032	0.73029378
62	Taste transduction_Homo sapiens_hsa04742	0.72444601
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70025270
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69539767
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66688250
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64880409
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62171808
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61583356
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59432423
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59407803
71	Metabolic pathways_Homo sapiens_hsa01100	0.58016466
72	One carbon pool by folate_Homo sapiens_hsa00670	0.53913166
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51464978
74	Salivary secretion_Homo sapiens_hsa04970	0.49243379
75	GABAergic synapse_Homo sapiens_hsa04727	0.48931500
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48209693
77	Viral myocarditis_Homo sapiens_hsa05416	0.48181171
78	Serotonergic synapse_Homo sapiens_hsa04726	0.47191649
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.46574549
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46334574
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45913499
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43850131
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42291045
84	Regulation of autophagy_Homo sapiens_hsa04140	0.41854299
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40097582
86	RNA transport_Homo sapiens_hsa03013	0.39449247
87	Sulfur metabolism_Homo sapiens_hsa00920	0.38657550
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38527087
89	Measles_Homo sapiens_hsa05162	0.35617530
90	Malaria_Homo sapiens_hsa05144	0.33791792
91	Circadian entrainment_Homo sapiens_hsa04713	0.31518072
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31439919
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.31130577
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31041709
95	Spliceosome_Homo sapiens_hsa03040	0.30907867
96	ABC transporters_Homo sapiens_hsa02010	0.24637806
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.23741595
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22464942
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21648363
100	Fatty acid elongation_Homo sapiens_hsa00062	0.21494619

RPL7P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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