RPL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.26474744
2formation of translation preinitiation complex (GO:0001731)5.39150478
3DNA deamination (GO:0045006)5.28828525
4* viral transcription (GO:0019083)4.98034183
5transcription from mitochondrial promoter (GO:0006390)4.97175044
6replication fork processing (GO:0031297)4.80201764
7* translational termination (GO:0006415)4.77655917
8ribosomal small subunit assembly (GO:0000028)4.61058783
9telomere maintenance via semi-conservative replication (GO:0032201)4.60474052
10embryonic process involved in female pregnancy (GO:0060136)4.58704812
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.49506012
12DNA strand elongation involved in DNA replication (GO:0006271)4.47014578
13somatic diversification of immune receptors via somatic mutation (GO:0002566)4.39672384
14somatic hypermutation of immunoglobulin genes (GO:0016446)4.39672384
15* translational elongation (GO:0006414)4.38935409
16proline metabolic process (GO:0006560)4.36926439
17* translational initiation (GO:0006413)4.29821039
18establishment of apical/basal cell polarity (GO:0035089)4.22833981
19DNA strand elongation (GO:0022616)4.21050947
20regulation of translational fidelity (GO:0006450)4.16962077
21* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10693990
22ribosomal small subunit biogenesis (GO:0042274)4.09910342
23maturation of SSU-rRNA (GO:0030490)4.08422788
24viral mRNA export from host cell nucleus (GO:0046784)4.06668093
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.98905172
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.91385568
27mitotic G1 DNA damage checkpoint (GO:0031571)3.91165917
28telomere maintenance via recombination (GO:0000722)3.85377477
29peptidyl-arginine omega-N-methylation (GO:0035247)3.84748300
30* protein targeting to membrane (GO:0006612)3.84432780
31* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81083238
32mitochondrial DNA metabolic process (GO:0032042)3.79003705
33establishment of integrated proviral latency (GO:0075713)3.78484942
34* translation (GO:0006412)3.75650903
35* viral life cycle (GO:0019058)3.74300221
36mitotic chromosome condensation (GO:0007076)3.73897960
37positive regulation of protein homooligomerization (GO:0032464)3.73113954
38* protein targeting to ER (GO:0045047)3.71042513
39base-excision repair (GO:0006284)3.69934708
40DNA unwinding involved in DNA replication (GO:0006268)3.69187609
41* cotranslational protein targeting to membrane (GO:0006613)3.68662099
42* cellular protein complex disassembly (GO:0043624)3.67968313
43negative regulation of RNA splicing (GO:0033119)3.67232532
44regulation of posttranscriptional gene silencing (GO:0060147)3.59304226
45regulation of gene silencing by miRNA (GO:0060964)3.59304226
46regulation of gene silencing by RNA (GO:0060966)3.59304226
47ribosomal large subunit biogenesis (GO:0042273)3.56576152
48Golgi transport vesicle coating (GO:0048200)3.53568934
49COPI coating of Golgi vesicle (GO:0048205)3.53568934
50protein maturation by protein folding (GO:0022417)3.53055614
51dosage compensation (GO:0007549)3.52366297
52* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51050589
53DNA strand renaturation (GO:0000733)3.50668192
54mitotic recombination (GO:0006312)3.50519226
55establishment of monopolar cell polarity (GO:0061162)3.49576866
56establishment or maintenance of monopolar cell polarity (GO:0061339)3.49576866
57negative regulation of mRNA processing (GO:0050686)3.48503564
58mRNA cleavage (GO:0006379)3.48350977
59termination of RNA polymerase II transcription (GO:0006369)3.46942826
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.46564025
61telomere maintenance via telomere lengthening (GO:0010833)3.46034044
62regulation of integrin activation (GO:0033623)3.44202043
63ribonucleoprotein complex biogenesis (GO:0022613)3.44142340
64mitotic G1/S transition checkpoint (GO:0044819)3.43520814
65* protein localization to endoplasmic reticulum (GO:0070972)3.42892004
66* protein complex disassembly (GO:0043241)3.39947579
67nucleobase-containing small molecule interconversion (GO:0015949)3.39860692
68DNA replication initiation (GO:0006270)3.36054347
69G1 DNA damage checkpoint (GO:0044783)3.35778062
70histone arginine methylation (GO:0034969)3.35714516
71pentose-phosphate shunt (GO:0006098)3.30111839
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.28118492
73mitotic nuclear envelope disassembly (GO:0007077)3.26944758
74ribosome biogenesis (GO:0042254)3.26128585
75* nuclear-transcribed mRNA catabolic process (GO:0000956)3.24612671
76regulation of mammary gland epithelial cell proliferation (GO:0033599)3.23656372
77cellular component biogenesis (GO:0044085)3.22256225
78regulation of sister chromatid cohesion (GO:0007063)3.21618501
79mitotic sister chromatid segregation (GO:0000070)3.20978272
80rRNA processing (GO:0006364)3.18252859
81DNA topological change (GO:0006265)3.14989663
82regulation of mitochondrial translation (GO:0070129)3.14251048
83ncRNA 3-end processing (GO:0043628)3.14235123
84folic acid-containing compound biosynthetic process (GO:0009396)3.13426485
85* macromolecular complex disassembly (GO:0032984)3.13058607
86protein localization to kinetochore (GO:0034501)3.13013025
87establishment of viral latency (GO:0019043)3.12282266
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11118487
89L-serine metabolic process (GO:0006563)3.09611740
90GDP-mannose metabolic process (GO:0019673)3.08716744
91regulation of double-strand break repair via homologous recombination (GO:0010569)3.08516637
92* mRNA catabolic process (GO:0006402)3.07130102
93* RNA catabolic process (GO:0006401)3.06938202
94positive regulation of chromosome segregation (GO:0051984)3.06724064
95rRNA metabolic process (GO:0016072)3.06158328
96negative regulation of cell cycle arrest (GO:0071157)3.06026245
97mitochondrial RNA metabolic process (GO:0000959)3.05215162
98regulation of protein homooligomerization (GO:0032462)3.03842683
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02955630
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02376839
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02376839
102positive regulation of mitotic sister chromatid separation (GO:1901970)3.02376839
103peptidyl-arginine N-methylation (GO:0035246)3.02370805
104peptidyl-arginine methylation (GO:0018216)3.02370805
105negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01951851
106meiotic chromosome segregation (GO:0045132)3.00477982
107nuclear envelope disassembly (GO:0051081)3.00088726
108membrane disassembly (GO:0030397)3.00088726
109kinetochore assembly (GO:0051382)2.98282960
110oxidative demethylation (GO:0070989)2.98233917
111NADPH regeneration (GO:0006740)2.97386240
112pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96939428
113guanosine-containing compound biosynthetic process (GO:1901070)2.96352026
114negative regulation of mRNA metabolic process (GO:1903312)2.96292766
115maturation of 5.8S rRNA (GO:0000460)2.96091615
116poly(A)+ mRNA export from nucleus (GO:0016973)2.92810877
117kinetochore organization (GO:0051383)2.92715804
118trophectodermal cell differentiation (GO:0001829)2.92535905
119glucose catabolic process (GO:0006007)2.91002587
120DNA duplex unwinding (GO:0032508)2.90743957
121heterochromatin organization (GO:0070828)2.90405715
122regulation of translational termination (GO:0006449)2.90334071
123non-recombinational repair (GO:0000726)2.89906318
124double-strand break repair via nonhomologous end joining (GO:0006303)2.89906318
125DNA geometric change (GO:0032392)2.88635722
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87507810
127UTP biosynthetic process (GO:0006228)2.86061774
128rRNA transcription (GO:0009303)2.85535818
129regulation of RNA export from nucleus (GO:0046831)2.85195312
130sister chromatid segregation (GO:0000819)2.85033424
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83621701
132protein complex localization (GO:0031503)2.81030203
133nuclear envelope reassembly (GO:0031468)2.80843743
134mitotic nuclear envelope reassembly (GO:0007084)2.80843743
135* establishment of protein localization to membrane (GO:0090150)2.79799881
136nucleosome disassembly (GO:0006337)2.78750618
137protein-DNA complex disassembly (GO:0032986)2.78750618
138pentose metabolic process (GO:0019321)2.76924874
139mitochondrial fusion (GO:0008053)2.75106546
140pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71920756
141ribosome assembly (GO:0042255)2.71613955
142folic acid metabolic process (GO:0046655)2.67293957
143oxidative phosphorylation (GO:0006119)2.66786771
144tRNA aminoacylation for protein translation (GO:0006418)2.63307170
145protein retention in ER lumen (GO:0006621)2.63138414
146mitotic metaphase plate congression (GO:0007080)2.61104520
147protein localization to chromosome, centromeric region (GO:0071459)2.59294172
148spliceosomal snRNP assembly (GO:0000387)2.59175336
149apoptotic process involved in morphogenesis (GO:0060561)2.58659556
150CTP metabolic process (GO:0046036)2.58035344
151CTP biosynthetic process (GO:0006241)2.58035344
152maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55793633
153negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53682049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17746580
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97906062
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56674613
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.19927108
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05496395
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63133725
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59586879
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49144560
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46573155
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42437149
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34646963
12MYC_22102868_ChIP-Seq_BL_Human2.34208578
13* VDR_21846776_ChIP-Seq_THP-1_Human2.13955890
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.11939356
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05880109
16* XRN2_22483619_ChIP-Seq_HELA_Human2.04782525
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90357455
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88473463
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.88287960
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85500416
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85500416
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85500416
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84070094
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77856373
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77853662
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75736241
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75196879
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75064860
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.71990718
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70811352
31* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70418149
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66880264
33TTF2_22483619_ChIP-Seq_HELA_Human1.63860259
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.61453352
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60649282
36* DCP1A_22483619_ChIP-Seq_HELA_Human1.59564859
37GABP_19822575_ChIP-Seq_HepG2_Human1.59518789
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59172995
39* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57155535
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55575803
41VDR_23849224_ChIP-Seq_CD4+_Human1.54292045
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.52907249
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52464538
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52392960
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52008845
46* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47151170
47* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43925971
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.42987121
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41159715
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41068072
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40713078
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39513283
53KDM5A_27292631_Chip-Seq_BREAST_Human1.39060007
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37103459
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36799042
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36141553
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35123692
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33153167
59FOXP3_21729870_ChIP-Seq_TREG_Human1.31752464
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31202176
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.31176048
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30689965
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30441335
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23707660
65ZNF263_19887448_ChIP-Seq_K562_Human1.23504350
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23312424
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23067504
68P68_20966046_ChIP-Seq_HELA_Human1.21102121
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21076740
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19898978
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18779964
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18181156
73TFEB_21752829_ChIP-Seq_HELA_Human1.17091618
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17068113
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15986507
76* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15958983
77AR_21909140_ChIP-Seq_LNCAP_Human1.15658038
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14281472
79POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14240698
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14007246
81CIITA_25753668_ChIP-Seq_RAJI_Human1.13294701
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12895998
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12743769
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12477255
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12149627
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11908159
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11743958
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10814957
89* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10355016
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.09634092
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.09548223
92* LXR_22292898_ChIP-Seq_THP-1_Human1.08690790
93* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07228217
94* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07104324
95* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06777144
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06217669
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05847611
98ATF3_27146783_Chip-Seq_COLON_Human1.05418074
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05086784
100* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05065942
101* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04384576
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04311965
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02909898
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02581066
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.02469940
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02279263
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02241340
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02190869
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.02139666
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01469211
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00925304
112* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99412376
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99146052
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98698343
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98601147
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96995942
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96479295
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.96325845
119MAF_26560356_Chip-Seq_TH1_Human0.96259013
120NCOR1_26117541_ChIP-Seq_K562_Human0.95686518
121UTX_26944678_Chip-Seq_JUKART_Human0.94863677
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94321074
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94251121
124HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94100545
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93819236
126RACK7_27058665_Chip-Seq_MCF-7_Human0.93500779
127KDM2B_26808549_Chip-Seq_DND41_Human0.93241018
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92782662
129* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92298672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.89613312
2MP0009379_abnormal_foot_pigmentation3.76889703
3MP0004957_abnormal_blastocyst_morpholog3.55095090
4MP0010094_abnormal_chromosome_stability3.54442354
5MP0003693_abnormal_embryo_hatching3.48911045
6MP0003111_abnormal_nucleus_morphology3.20999772
7MP0009278_abnormal_bone_marrow3.11538050
8MP0003077_abnormal_cell_cycle2.85968115
9MP0010030_abnormal_orbit_morphology2.82728314
10MP0010352_gastrointestinal_tract_polyps2.57518968
11MP0008058_abnormal_DNA_repair2.35583941
12MP0010234_abnormal_vibrissa_follicle2.28335056
13MP0005451_abnormal_body_composition2.28240506
14MP0003786_premature_aging2.07665425
15MP0008932_abnormal_embryonic_tissue2.07183220
16MP0005397_hematopoietic_system_phenotyp1.99871770
17MP0001545_abnormal_hematopoietic_system1.99871770
18MP0001730_embryonic_growth_arrest1.98960345
19MP0000490_abnormal_crypts_of1.98018093
20MP0000350_abnormal_cell_proliferation1.90377945
21MP0005076_abnormal_cell_differentiation1.87621133
22MP0004185_abnormal_adipocyte_glucose1.87287052
23MP0001697_abnormal_embryo_size1.79868580
24MP0002396_abnormal_hematopoietic_system1.74664719
25MP0002086_abnormal_extraembryonic_tissu1.74064868
26MP0002084_abnormal_developmental_patter1.73885412
27MP0004197_abnormal_fetal_growth/weight/1.71936161
28MP0002877_abnormal_melanocyte_morpholog1.70898275
29MP0004233_abnormal_muscle_weight1.70732575
30MP0004133_heterotaxia1.68540413
31MP0002085_abnormal_embryonic_tissue1.66937090
32MP0000566_synostosis1.65594843
33MP0003119_abnormal_digestive_system1.64055702
34MP0001672_abnormal_embryogenesis/_devel1.63488478
35MP0005380_embryogenesis_phenotype1.63488478
36MP0003567_abnormal_fetal_cardiomyocyte1.62787503
37MP0008995_early_reproductive_senescence1.61618382
38MP0008007_abnormal_cellular_replicative1.60868326
39MP0003890_abnormal_embryonic-extraembry1.60849221
40MP0000678_abnormal_parathyroid_gland1.60210657
41MP0005171_absent_coat_pigmentation1.57458964
42MP0003283_abnormal_digestive_organ1.55488262
43MP0009672_abnormal_birth_weight1.55271285
44MP0008260_abnormal_autophagy1.55240444
45MP0010307_abnormal_tumor_latency1.53510448
46MP0001293_anophthalmia1.53343423
47MP0002009_preneoplasia1.53321264
48MP0002653_abnormal_ependyma_morphology1.52874826
49MP0004858_abnormal_nervous_system1.49214429
50MP0002080_prenatal_lethality1.49011233
51MP0005174_abnormal_tail_pigmentation1.45209910
52MP0002019_abnormal_tumor_incidence1.44659091
53MP0009333_abnormal_splenocyte_physiolog1.42136563
54MP0003984_embryonic_growth_retardation1.41468546
55MP0002088_abnormal_embryonic_growth/wei1.37327349
56MP0003806_abnormal_nucleotide_metabolis1.35863610
57MP0008877_abnormal_DNA_methylation1.35115905
58MP0001346_abnormal_lacrimal_gland1.33029471
59MP0003705_abnormal_hypodermis_morpholog1.32512726
60MP0003315_abnormal_perineum_morphology1.29449105
61MP0003763_abnormal_thymus_physiology1.28725297
62MP0003186_abnormal_redox_activity1.28009930
63MP0000313_abnormal_cell_death1.23460729
64MP0003453_abnormal_keratinocyte_physiol1.23422392
65MP0006035_abnormal_mitochondrial_morpho1.20891852
66MP0001348_abnormal_lacrimal_gland1.20650899
67MP0003123_paternal_imprinting1.20219755
68MP0005058_abnormal_lysosome_morphology1.17606339
69MP0001661_extended_life_span1.17045588
70MP0002249_abnormal_larynx_morphology1.15809358
71MP0000685_abnormal_immune_system1.14370628
72MP0002282_abnormal_trachea_morphology1.13745843
73MP0002111_abnormal_tail_morphology1.13386508
74MP0002098_abnormal_vibrissa_morphology1.13349271
75MP0001873_stomach_inflammation1.11899765
76MP0009053_abnormal_anal_canal1.10432677
77MP0000371_diluted_coat_color1.07625638
78MP0004808_abnormal_hematopoietic_stem1.06726361
79MP0005023_abnormal_wound_healing1.03790828
80MP0000703_abnormal_thymus_morphology1.03767211
81MP0000579_abnormal_nail_morphology1.02429465
82MP0003566_abnormal_cell_adhesion1.02298636
83MP0006036_abnormal_mitochondrial_physio1.00691343
84MP0005501_abnormal_skin_physiology1.00062661
85MP0000689_abnormal_spleen_morphology0.96862234
86MP0005075_abnormal_melanosome_morpholog0.96672527
87MP0002398_abnormal_bone_marrow0.95665620
88MP0001881_abnormal_mammary_gland0.95178025
89MP0005666_abnormal_adipose_tissue0.94286995
90MP0001216_abnormal_epidermal_layer0.93006368
91MP0002722_abnormal_immune_system0.92457221
92MP0000467_abnormal_esophagus_morphology0.92275419
93MP0000470_abnormal_stomach_morphology0.91206615
94MP0002163_abnormal_gland_morphology0.90230777
95MP0002405_respiratory_system_inflammati0.90108779
96MP0002089_abnormal_postnatal_growth/wei0.89642209
97MP0000477_abnormal_intestine_morphology0.88614792
98MP0002796_impaired_skin_barrier0.88125887
99MP0001727_abnormal_embryo_implantation0.87989713
100MP0000750_abnormal_muscle_regeneration0.87954545
101MP0000377_abnormal_hair_follicle0.86347196
102MP0006072_abnormal_retinal_apoptosis0.85917468
103MP0000003_abnormal_adipose_tissue0.85136009
104MP0000858_altered_metastatic_potential0.84289014
105MP0005384_cellular_phenotype0.83966904
106MP0003718_maternal_effect0.83516263
107MP0006292_abnormal_olfactory_placode0.83290216
108MP0009931_abnormal_skin_appearance0.82262730
109MP0004782_abnormal_surfactant_physiolog0.82090977
110MP0003942_abnormal_urinary_system0.81975468
111MP0005621_abnormal_cell_physiology0.81656312
112MP0000537_abnormal_urethra_morphology0.81619715
113MP0002932_abnormal_joint_morphology0.81269936
114MP0010771_integument_phenotype0.80293185
115MP0003941_abnormal_skin_development0.77920199
116MP0002166_altered_tumor_susceptibility0.77764069
117MP0002075_abnormal_coat/hair_pigmentati0.77195378
118MP0000627_abnormal_mammary_gland0.75648762
119MP0000462_abnormal_digestive_system0.75040047
120MP0001145_abnormal_male_reproductive0.74979757
121MP0005375_adipose_tissue_phenotype0.72203719
122MP0004264_abnormal_extraembryonic_tissu0.71541574
123MP0001849_ear_inflammation0.71407054
124MP0002060_abnormal_skin_morphology0.70992584
125MP0003935_abnormal_craniofacial_develop0.70707878
126MP0000733_abnormal_muscle_development0.70591556
127MP0002429_abnormal_blood_cell0.69357285
128MP0002092_abnormal_eye_morphology0.68630527
129MP0002697_abnormal_eye_size0.68043722
130MP0000762_abnormal_tongue_morphology0.67442350
131MP0000015_abnormal_ear_pigmentation0.66349899
132MP0002210_abnormal_sex_determination0.66195068
133MP0010155_abnormal_intestine_physiology0.65946517
134MP0001915_intracranial_hemorrhage0.65690149
135MP0000432_abnormal_head_morphology0.64622496
136MP0002114_abnormal_axial_skeleton0.64210003
137MP0002269_muscular_atrophy0.64038341
138MP0002006_tumorigenesis0.63297220
139MP0001186_pigmentation_phenotype0.62434885
140MP0002132_abnormal_respiratory_system0.62255618
141MP0003828_pulmonary_edema0.60882123
142MP0008770_decreased_survivor_rate0.60674505
143MP0000358_abnormal_cell_content/0.59953246
144MP0002925_abnormal_cardiovascular_devel0.59727508

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.40122566
2Rib fusion (HP:0000902)4.15603142
3Abnormal number of erythroid precursors (HP:0012131)3.99972213
4Reticulocytopenia (HP:0001896)3.97566773
5Poikiloderma (HP:0001029)3.96671676
6Selective tooth agenesis (HP:0001592)3.77257782
7Facial hemangioma (HP:0000329)3.73759568
8Pustule (HP:0200039)3.71525214
9Microvesicular hepatic steatosis (HP:0001414)3.64457819
10Absent thumb (HP:0009777)3.64049821
11Progressive muscle weakness (HP:0003323)3.63624638
12Basal cell carcinoma (HP:0002671)3.52014531
13Abnormal hemoglobin (HP:0011902)3.42387866
14Ulnar bowing (HP:0003031)3.41460060
15Annular pancreas (HP:0001734)3.35046638
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.34961688
17Rectovaginal fistula (HP:0000143)3.33678711
18Rectal fistula (HP:0100590)3.33678711
19Concave nail (HP:0001598)3.25870248
20Abnormal gallbladder physiology (HP:0012438)3.24739796
21Cholecystitis (HP:0001082)3.24739796
22Absent radius (HP:0003974)3.18583776
23Squamous cell carcinoma (HP:0002860)3.16130472
24Patellar aplasia (HP:0006443)3.13302815
25Hyperacusis (HP:0010780)3.11488649
26Abnormality of reticulocytes (HP:0004312)3.10131282
27Aplasia/hypoplasia of the humerus (HP:0006507)3.06831753
28Ragged-red muscle fibers (HP:0003200)3.01576605
29Intestinal fistula (HP:0100819)3.00169486
30Short humerus (HP:0005792)2.96034627
31Aplasia involving forearm bones (HP:0009822)2.95543313
32Absent forearm bone (HP:0003953)2.95543313
33Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.94899304
34Vertebral hypoplasia (HP:0008417)2.94899304
35Aplasia/Hypoplasia of the patella (HP:0006498)2.91200486
36Vaginal fistula (HP:0004320)2.90389222
37Broad distal phalanx of finger (HP:0009836)2.88773103
38Tongue fasciculations (HP:0001308)2.87560262
39Ependymoma (HP:0002888)2.82557114
40Colon cancer (HP:0003003)2.72819881
41Premature graying of hair (HP:0002216)2.72343939
42Abnormal number of incisors (HP:0011064)2.68894205
43Orthostatic hypotension (HP:0001278)2.64178843
44Muscle fibrillation (HP:0010546)2.63687200
45Alopecia of scalp (HP:0002293)2.60917517
46Abnormality of glycolysis (HP:0004366)2.53693178
47Long palpebral fissure (HP:0000637)2.48896081
48Increased IgM level (HP:0003496)2.48112899
49Breast hypoplasia (HP:0003187)2.47090294
50Pallor (HP:0000980)2.46978318
51Macrocytic anemia (HP:0001972)2.46182160
52Astrocytoma (HP:0009592)2.45821765
53Abnormality of the astrocytes (HP:0100707)2.45821765
54Testicular atrophy (HP:0000029)2.39089446
55Hypoplasia of the radius (HP:0002984)2.37219691
56Missing ribs (HP:0000921)2.35975034
57Abnormality of the labia minora (HP:0012880)2.35544523
58Abnormality of the umbilical cord (HP:0010881)2.35245410
59Intestinal atresia (HP:0011100)2.32260415
60Congenital hip dislocation (HP:0001374)2.31066730
61Hypochromic anemia (HP:0001931)2.24647258
62Proximal placement of thumb (HP:0009623)2.21558267
63Turricephaly (HP:0000262)2.20203764
64Insomnia (HP:0100785)2.18934500
65Birth length less than 3rd percentile (HP:0003561)2.18664952
66Broad alveolar ridges (HP:0000187)2.18124275
67Microretrognathia (HP:0000308)2.16930941
68Degeneration of anterior horn cells (HP:0002398)2.15742523
69Abnormality of the anterior horn cell (HP:0006802)2.15742523
70Medulloblastoma (HP:0002885)2.14602653
71Deviation of the thumb (HP:0009603)2.14265364
72Reticulocytosis (HP:0001923)2.13262837
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12672386
74Progressive external ophthalmoplegia (HP:0000590)2.12249227
75Achilles tendon contracture (HP:0001771)2.10950467
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10806127
77Trismus (HP:0000211)2.10277965
78Neoplasm of the oral cavity (HP:0100649)2.10094076
79Abnormality of the ileum (HP:0001549)2.09995938
80Short chin (HP:0000331)2.09964992
81Volvulus (HP:0002580)2.08739364
82Male infertility (HP:0003251)2.07398658
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06914085
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06914085
85Myopathic facies (HP:0002058)2.06038552
86Cerebral aneurysm (HP:0004944)2.04880978
87Vertebral compression fractures (HP:0002953)2.04772450
88Seborrheic dermatitis (HP:0001051)2.04617352
89Short thumb (HP:0009778)2.04470629
90Septate vagina (HP:0001153)2.04102989
91Rhabdomyosarcoma (HP:0002859)2.03815031
92Vertebral fusion (HP:0002948)2.03629680
93Pili torti (HP:0003777)2.01180443
94Albinism (HP:0001022)2.01024292
95Abnormality of the aortic arch (HP:0012303)2.00291555
96Bowed forearm bones (HP:0003956)1.99961000
97Bowing of the arm (HP:0006488)1.99961000
98High anterior hairline (HP:0009890)1.99253840
99IgA deficiency (HP:0002720)1.98227181
100Abnormal mitochondria in muscle tissue (HP:0008316)1.96931946
101Hypotelorism (HP:0000601)1.96305674
10211 pairs of ribs (HP:0000878)1.96110807
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.95712658
104Short 5th finger (HP:0009237)1.93960217
105Myelodysplasia (HP:0002863)1.93534170
106Increased intramyocellular lipid droplets (HP:0012240)1.93065132
107Coronal craniosynostosis (HP:0004440)1.92896428
108Acute lymphatic leukemia (HP:0006721)1.92737999
109Overriding aorta (HP:0002623)1.92512408
110Chromsome breakage (HP:0040012)1.91650022
111Glioma (HP:0009733)1.90539683
112Asplenia (HP:0001746)1.89597716
113Increased serum pyruvate (HP:0003542)1.89047956
114Multiple enchondromatosis (HP:0005701)1.88881622
115Hypokinesia (HP:0002375)1.88788348
116Abnormality of male internal genitalia (HP:0000022)1.88532573
117Oral leukoplakia (HP:0002745)1.88249555
118Spinal muscular atrophy (HP:0007269)1.88211091
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87920319
120Truncus arteriosus (HP:0001660)1.86958070
121Thrombocytosis (HP:0001894)1.85485461
122Horseshoe kidney (HP:0000085)1.84635175
123Premature skin wrinkling (HP:0100678)1.84124495
124Hypotrichosis (HP:0001006)1.83271202
125Abnormality of the distal phalanges of the toes (HP:0010182)1.83160841
126Hypochromic microcytic anemia (HP:0004840)1.83113068
127Rough bone trabeculation (HP:0100670)1.82975765
128Increased muscle lipid content (HP:0009058)1.82222996
129Joint stiffness (HP:0001387)1.81531367
130Partial duplication of thumb phalanx (HP:0009944)1.81386186
131Increased nuchal translucency (HP:0010880)1.81078010
132Gastrointestinal atresia (HP:0002589)1.80935836
133Atresia of the external auditory canal (HP:0000413)1.80863935
134Distal lower limb muscle weakness (HP:0009053)1.79795365
135Premature ovarian failure (HP:0008209)1.79227202
136Dysautonomia (HP:0002459)1.79193242
137Neoplasm of the pancreas (HP:0002894)1.78800077
138Deep palmar crease (HP:0006191)1.77793337
139Absent epiphyses (HP:0010577)1.77759770
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77759770
141Facial cleft (HP:0002006)1.77579320
142Abnormality of the calcaneus (HP:0008364)1.76667570
143Generalized amyotrophy (HP:0003700)1.76078218
144Hyperthyroidism (HP:0000836)1.76063406
145Duplication of thumb phalanx (HP:0009942)1.74789778
146Gout (HP:0001997)1.74607557
147Abnormal umbilical cord blood vessels (HP:0011403)1.74242758
148Single umbilical artery (HP:0001195)1.74242758
149Abnormality of the fetal cardiovascular system (HP:0010948)1.74242758
150Exercise intolerance (HP:0003546)1.73895367
151Muscle fiber atrophy (HP:0100295)1.73864885
152Agnosia (HP:0010524)1.73698791
153Hypertensive crisis (HP:0100735)1.73416947
154Glossoptosis (HP:0000162)1.72051937
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.71941741
156Hepatocellular necrosis (HP:0001404)1.71574965
157Anteriorly placed anus (HP:0001545)1.70857739
158Abnormality of the Achilles tendon (HP:0005109)1.69970351
159Flattened epiphyses (HP:0003071)1.69546623
160Polycythemia (HP:0001901)1.69219145
161Bifid uvula (HP:0000193)1.68580155
162Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68475774
163Acute encephalopathy (HP:0006846)1.67032660
164Abnormalities of placenta or umbilical cord (HP:0001194)1.66737428
165Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65865536
166Cholelithiasis (HP:0001081)1.65737030
167Secondary amenorrhea (HP:0000869)1.65387823
168Hypoparathyroidism (HP:0000829)1.64873572
169Abnormal trabecular bone morphology (HP:0100671)1.63133777
170Patellar dislocation (HP:0002999)1.63080122
171Sparse eyelashes (HP:0000653)1.62475396
172Disproportionate tall stature (HP:0001519)1.62075685
173Partial duplication of the phalanx of hand (HP:0009999)1.61516783
174Elfin facies (HP:0004428)1.60641581
175Microglossia (HP:0000171)1.59959347
176Fasciculations (HP:0002380)1.59783201
177Nasolacrimal duct obstruction (HP:0000579)1.59403875
178Respiratory difficulties (HP:0002880)1.59282443
179Abnormal hair laboratory examination (HP:0003328)1.58823903
180Abnormality of the thoracic spine (HP:0100711)1.58132191
181Increased serum lactate (HP:0002151)1.57821515
182Abnormality of the tricuspid valve (HP:0001702)1.57375336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.02606197
2SMG13.97406150
3VRK23.33563256
4DDR23.17732687
5MAPK152.79838047
6MAP3K112.76706989
7MAP3K62.60133646
8BUB12.48147093
9IRAK32.39367394
10PIM22.34508695
11WEE12.33462128
12MAP3K102.32079634
13EEF2K2.31120644
14NME22.22501294
15CDC72.19125620
16CDK72.13899431
17SIK12.09790581
18RPS6KB22.04491444
19NEK22.02234395
20MATK1.89209872
21PRPF4B1.80152677
22TYRO31.79663643
23PBK1.75334449
24BMX1.75136408
25PIM11.67069601
26TRIB31.61267687
27ARAF1.59268641
28DYRK31.58311493
29MST1R1.57129983
30FGR1.56864213
31DAPK11.56015683
32CDK121.46257255
33ERN11.45791782
34PLK11.45237833
35PDGFRA1.44330184
36CSK1.42679799
37CDK61.40473449
38MAP4K11.40299415
39TESK11.40025560
40PKN21.38086464
41EPHA21.37116725
42NEK11.36674160
43UHMK11.36669608
44DYRK1B1.33747674
45PRKD21.30155275
46NME11.28427666
47PASK1.27149093
48STK161.24877802
49ATR1.21776642
50YES11.20749770
51CHEK21.17227142
52BRAF1.16448589
53TLK11.14915114
54RPS6KL11.14628111
55RPS6KC11.14628111
56PINK11.10935649
57CDK41.10797766
58LRRK21.07807461
59CDK81.06935881
60BCKDK1.06545061
61STK101.06332513
62TTK1.04161288
63RPS6KA61.03004216
64MAP3K80.96850779
65PAK40.96269575
66RPS6KA40.94944188
67MAP2K20.94299994
68FLT30.94136064
69* AURKB0.93534841
70TRPM70.89725269
71TGFBR10.86774662
72AURKA0.86140845
73MTOR0.86051970
74KDR0.84343785
75CHEK10.83560923
76SCYL20.83408299
77TESK20.82848609
78MAPK110.82115982
79BRSK20.81451018
80ALK0.81449313
81PTK60.79932617
82LMTK20.79921565
83MAPKAPK30.79684899
84TSSK60.78283834
85LATS20.77601418
86CDK20.75505635
87RPS6KA10.70953656
88SRPK10.70205646
89ACVR1B0.69599539
90TAOK20.67728784
91TTN0.66185752
92MET0.65750130
93FGFR40.64748466
94CSNK2A20.63648936
95PRKD30.63521780
96TAF10.63357486
97PTK20.62743731
98GSK3A0.62151384
99PAK20.59586493
100CSNK2A10.59550369
101ZAP700.59180912
102ILK0.57485825
103ATM0.56113872
104CDK190.56069680
105GRK60.54982773
106MAP2K30.54845719
107PAK10.54225917
108EIF2AK10.54092270
109IRAK20.53161683
110STK40.52767976
111MUSK0.50842018
112MKNK10.50222456
113RAF10.49914975
114LIMK10.49721471
115PDK20.49096499
116SIK30.48533812
117CDC42BPA0.47851421
118ABL20.47765907
119CDK90.45458169
120HIPK20.44398701
121PRKCI0.43865825
122BRSK10.42706618
123CLK10.42002300
124VRK10.41598873
125MAP3K130.39839834
126CDK10.39489397
127MAPKAPK20.38651439
128STK30.36940595
129AKT20.36500507
130AKT30.35642995
131RPS6KB10.35320433
132MAP3K90.35125547
133LYN0.34072745
134BTK0.33502835
135MAPK10.31719740
136CDK11A0.30110698
137PDPK10.29781333
138MAPK30.27510990

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.87582202
2Mismatch repair_Homo sapiens_hsa034304.87566267
3* Ribosome_Homo sapiens_hsa030104.08020084
4Base excision repair_Homo sapiens_hsa034104.02212703
5Spliceosome_Homo sapiens_hsa030403.19951967
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09734235
7RNA transport_Homo sapiens_hsa030132.85263226
8Nucleotide excision repair_Homo sapiens_hsa034202.80960910
9Homologous recombination_Homo sapiens_hsa034402.49949475
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27406670
11Cell cycle_Homo sapiens_hsa041102.18372127
12One carbon pool by folate_Homo sapiens_hsa006702.07192513
13mRNA surveillance pathway_Homo sapiens_hsa030152.04851973
14Proteasome_Homo sapiens_hsa030501.96312822
15RNA polymerase_Homo sapiens_hsa030201.93575889
16Fanconi anemia pathway_Homo sapiens_hsa034601.86613221
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84803197
18p53 signaling pathway_Homo sapiens_hsa041151.74221459
19Fatty acid biosynthesis_Homo sapiens_hsa000611.69718167
20Pyrimidine metabolism_Homo sapiens_hsa002401.56676695
21Notch signaling pathway_Homo sapiens_hsa043301.34929524
22Sulfur relay system_Homo sapiens_hsa041221.28238142
23RNA degradation_Homo sapiens_hsa030181.26321536
24Parkinsons disease_Homo sapiens_hsa050121.22369307
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20817295
26Biosynthesis of amino acids_Homo sapiens_hsa012301.19323688
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18901346
28Hippo signaling pathway_Homo sapiens_hsa043901.16511955
29Primary immunodeficiency_Homo sapiens_hsa053401.15735393
30Oxidative phosphorylation_Homo sapiens_hsa001901.13724380
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13326276
32Huntingtons disease_Homo sapiens_hsa050161.12567809
33Non-homologous end-joining_Homo sapiens_hsa034501.11724504
34mTOR signaling pathway_Homo sapiens_hsa041501.11649226
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07763892
36Vitamin B6 metabolism_Homo sapiens_hsa007501.06606997
37Fatty acid elongation_Homo sapiens_hsa000621.06314090
38Pyruvate metabolism_Homo sapiens_hsa006201.03973830
39Hedgehog signaling pathway_Homo sapiens_hsa043401.03581795
40Bladder cancer_Homo sapiens_hsa052191.03079760
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02334767
42Viral carcinogenesis_Homo sapiens_hsa052031.02228991
43Basal transcription factors_Homo sapiens_hsa030221.01738705
44Epstein-Barr virus infection_Homo sapiens_hsa051690.98353327
45Basal cell carcinoma_Homo sapiens_hsa052170.96049020
46Adherens junction_Homo sapiens_hsa045200.91716596
47Herpes simplex infection_Homo sapiens_hsa051680.87386108
48TGF-beta signaling pathway_Homo sapiens_hsa043500.87257729
49Shigellosis_Homo sapiens_hsa051310.86791738
50Small cell lung cancer_Homo sapiens_hsa052220.86368045
51MicroRNAs in cancer_Homo sapiens_hsa052060.83212822
52Folate biosynthesis_Homo sapiens_hsa007900.83179849
53Thyroid cancer_Homo sapiens_hsa052160.82742410
54Systemic lupus erythematosus_Homo sapiens_hsa053220.82570803
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82418599
56Chronic myeloid leukemia_Homo sapiens_hsa052200.82091356
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81497129
58HTLV-I infection_Homo sapiens_hsa051660.80355263
59Colorectal cancer_Homo sapiens_hsa052100.79030606
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77618166
61Legionellosis_Homo sapiens_hsa051340.76474746
62Oocyte meiosis_Homo sapiens_hsa041140.76378991
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.74331700
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73837734
65Acute myeloid leukemia_Homo sapiens_hsa052210.71714296
66Arginine and proline metabolism_Homo sapiens_hsa003300.70772575
67Other glycan degradation_Homo sapiens_hsa005110.69883839
68Antigen processing and presentation_Homo sapiens_hsa046120.66529439
69Alzheimers disease_Homo sapiens_hsa050100.63475431
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62473129
71Fructose and mannose metabolism_Homo sapiens_hsa000510.57920347
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57315108
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56608948
74Viral myocarditis_Homo sapiens_hsa054160.56221231
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56048236
76Wnt signaling pathway_Homo sapiens_hsa043100.54898351
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.53176181
78VEGF signaling pathway_Homo sapiens_hsa043700.52398044
79Vibrio cholerae infection_Homo sapiens_hsa051100.52371986
80Selenocompound metabolism_Homo sapiens_hsa004500.52042492
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51117713
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50288001
83Apoptosis_Homo sapiens_hsa042100.49980655
84Purine metabolism_Homo sapiens_hsa002300.49511120
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48341306
86Pentose phosphate pathway_Homo sapiens_hsa000300.45971404
87Lysine degradation_Homo sapiens_hsa003100.45652925
88Hepatitis B_Homo sapiens_hsa051610.44892077
89Galactose metabolism_Homo sapiens_hsa000520.44585881
90Metabolic pathways_Homo sapiens_hsa011000.44128889
91Phenylalanine metabolism_Homo sapiens_hsa003600.43917656
92Arginine biosynthesis_Homo sapiens_hsa002200.42805121
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41339857
94Measles_Homo sapiens_hsa051620.40989323
95Glutathione metabolism_Homo sapiens_hsa004800.39619118
96Insulin signaling pathway_Homo sapiens_hsa049100.39260728
97HIF-1 signaling pathway_Homo sapiens_hsa040660.38147392
98B cell receptor signaling pathway_Homo sapiens_hsa046620.38041037
99Proteoglycans in cancer_Homo sapiens_hsa052050.37312102
100Pathways in cancer_Homo sapiens_hsa052000.36899578
101Tight junction_Homo sapiens_hsa045300.36847696
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.35889710
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35617412
104N-Glycan biosynthesis_Homo sapiens_hsa005100.35261465
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33760057
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.31494786
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30110712
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29008316
109Endometrial cancer_Homo sapiens_hsa052130.28043191
110Prostate cancer_Homo sapiens_hsa052150.27856441
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27536235
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27083514
113Prion diseases_Homo sapiens_hsa050200.26914357
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25911856
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25334024
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24999355
117Non-small cell lung cancer_Homo sapiens_hsa052230.24835255
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24777876
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24638631
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23787841
121Pancreatic cancer_Homo sapiens_hsa052120.23344126
122Circadian rhythm_Homo sapiens_hsa047100.22148315
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21304314
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19737139
125AMPK signaling pathway_Homo sapiens_hsa041520.19480597
126Carbon metabolism_Homo sapiens_hsa012000.18324746
127Focal adhesion_Homo sapiens_hsa045100.17706208
128Alcoholism_Homo sapiens_hsa050340.15473804

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