RPL8P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of prostaglandin secretion (GO:0032308)7.57619216
2viral transcription (GO:0019083)7.46275489
3ribosomal small subunit assembly (GO:0000028)7.25290420
4translational termination (GO:0006415)7.18064598
5translational elongation (GO:0006414)6.28121649
6regulation of prostaglandin secretion (GO:0032306)6.18726620
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.11039748
8cotranslational protein targeting to membrane (GO:0006613)5.99903287
9protein targeting to ER (GO:0045047)5.97028505
10ribosomal small subunit biogenesis (GO:0042274)5.76622669
11regulation of glucocorticoid secretion (GO:2000849)5.68108838
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.67666405
13protein localization to endoplasmic reticulum (GO:0070972)5.61083572
14viral life cycle (GO:0019058)5.51249113
15DNA deamination (GO:0045006)5.47798777
16positive regulation of icosanoid secretion (GO:0032305)5.46522820
17positive regulation of fatty acid transport (GO:2000193)5.41381043
18cellular protein complex disassembly (GO:0043624)5.36048610
19protein neddylation (GO:0045116)5.21479025
20behavioral response to nicotine (GO:0035095)5.17234101
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.12940696
22maturation of SSU-rRNA (GO:0030490)5.00607250
23translational initiation (GO:0006413)4.71053195
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57316430
25ATP synthesis coupled proton transport (GO:0015986)4.57316430
26regulation of corticosteroid hormone secretion (GO:2000846)4.53526260
27ribosomal large subunit biogenesis (GO:0042273)4.50145506
28protein complex disassembly (GO:0043241)4.49324588
29macromolecular complex disassembly (GO:0032984)4.23572327
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19881574
31phosphatidylinositol acyl-chain remodeling (GO:0036149)4.15757478
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15165110
33chaperone-mediated protein transport (GO:0072321)4.10326152
34protein targeting to membrane (GO:0006612)3.99604551
35regulation of icosanoid secretion (GO:0032303)3.94152872
36regulation of appetite (GO:0032098)3.90916027
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87974967
38translation (GO:0006412)3.87757175
39nonmotile primary cilium assembly (GO:0035058)3.80136563
40GTP biosynthetic process (GO:0006183)3.68650050
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.66552565
42phosphatidylserine acyl-chain remodeling (GO:0036150)3.66502977
43ribonucleoprotein complex biogenesis (GO:0022613)3.66336429
44NADH dehydrogenase complex assembly (GO:0010257)3.63202413
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63202413
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.63202413
47mRNA catabolic process (GO:0006402)3.46261887
48cellular component biogenesis (GO:0044085)3.44094467
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.42830534
50regulation of steroid hormone secretion (GO:2000831)3.35959612
51protein complex biogenesis (GO:0070271)3.33160705
52anterograde synaptic vesicle transport (GO:0048490)3.32806427
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28452538
54ubiquinone biosynthetic process (GO:0006744)3.26365736
55metallo-sulfur cluster assembly (GO:0031163)3.25730123
56iron-sulfur cluster assembly (GO:0016226)3.25730123
57UTP biosynthetic process (GO:0006228)3.21830774
58base-excision repair, AP site formation (GO:0006285)3.18377775
59positive regulation of organic acid transport (GO:0032892)3.16231971
60RNA catabolic process (GO:0006401)3.13463622
61rRNA processing (GO:0006364)3.07209470
62regulation of cilium movement (GO:0003352)3.06839701
63phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.06016718
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.05147901
65termination of RNA polymerase III transcription (GO:0006386)3.05147901
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04418187
67rRNA metabolic process (GO:0016072)3.02527069
68positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02066959
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01975906
70mitochondrial respiratory chain complex assembly (GO:0033108)3.01699837
71negative regulation of sterol transport (GO:0032372)3.01050754
72negative regulation of cholesterol transport (GO:0032375)3.01050754
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99990910
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99990910
75regulation of isotype switching to IgG isotypes (GO:0048302)2.98537894
76UTP metabolic process (GO:0046051)2.98211835
77electron transport chain (GO:0022900)2.95171210
78positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.93014830
79ubiquinone metabolic process (GO:0006743)2.92977017
80pyrimidine nucleotide catabolic process (GO:0006244)2.86576273
81respiratory electron transport chain (GO:0022904)2.82695842
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82550455
83positive regulation of defense response to virus by host (GO:0002230)2.81571161
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80540338
85regulation of immunoglobulin secretion (GO:0051023)2.77011726
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.76533774
87ncRNA 3-end processing (GO:0043628)2.76477167
88protein-cofactor linkage (GO:0018065)2.75090350
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70164475
90substrate-independent telencephalic tangential migration (GO:0021826)2.70164475
91rRNA modification (GO:0000154)2.70070688
92ribosome biogenesis (GO:0042254)2.65419375
93phosphatidylcholine acyl-chain remodeling (GO:0036151)2.63412005
94regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.62557451
95tRNA processing (GO:0008033)2.62080721
96respiratory chain complex IV assembly (GO:0008535)2.61800828
97establishment of protein localization to membrane (GO:0090150)2.61370334
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60586088
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58923884
100positive regulation of cell fate commitment (GO:0010455)2.58912223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.03462871
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.02734924
3EZH2_22144423_ChIP-Seq_EOC_Human3.90991584
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63547578
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.50763921
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15290582
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.96792906
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95867046
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.89546439
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89243430
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87847254
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61071702
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48706623
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.45038335
15VDR_23849224_ChIP-Seq_CD4+_Human2.29483205
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.24521058
17ELK1_19687146_ChIP-ChIP_HELA_Human2.20263634
18ZNF274_21170338_ChIP-Seq_K562_Hela2.15545631
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01100365
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.95922921
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87186415
22TTF2_22483619_ChIP-Seq_HELA_Human1.80045063
23MYC_18940864_ChIP-ChIP_HL60_Human1.78869360
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75122995
25STAT1_20625510_ChIP-Seq_HELA_Human1.74152083
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72218123
27TP53_22573176_ChIP-Seq_HFKS_Human1.66277822
28XRN2_22483619_ChIP-Seq_HELA_Human1.65763120
29FOXP3_21729870_ChIP-Seq_TREG_Human1.63771034
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63629881
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.62961202
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58701679
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47743364
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47367700
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46792461
36VDR_22108803_ChIP-Seq_LS180_Human1.46597492
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.43805695
38GABP_19822575_ChIP-Seq_HepG2_Human1.40455843
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37780267
40NCOR_22424771_ChIP-Seq_293T_Human1.36819356
41NANOG_20526341_ChIP-Seq_ESCs_Human1.34792468
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34583198
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32034584
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31983111
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30938068
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30692195
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27357345
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26792356
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.24822465
50AR_20517297_ChIP-Seq_VCAP_Human1.22097144
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.21565673
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20857141
53ERA_21632823_ChIP-Seq_H3396_Human1.18883941
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17953624
55CTCF_20526341_ChIP-Seq_ESCs_Human1.16458335
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16082883
57IRF1_19129219_ChIP-ChIP_H3396_Human1.16029259
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13353492
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.13353492
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.12859264
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09756101
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08641708
63TAF2_19829295_ChIP-Seq_ESCs_Human1.08383016
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05562907
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04798097
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04730639
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04012417
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03839770
69IGF1R_20145208_ChIP-Seq_DFB_Human1.02624935
70P53_21459846_ChIP-Seq_SAOS-2_Human1.01830625
71FOXH1_21741376_ChIP-Seq_ESCs_Human1.01449725
72MYC_19829295_ChIP-Seq_ESCs_Human1.01444390
73OCT4_20526341_ChIP-Seq_ESCs_Human0.99401385
74HOXB7_26014856_ChIP-Seq_BT474_Human0.98477596
75GATA3_26560356_Chip-Seq_TH2_Human0.97786395
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97413073
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97244500
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.96524297
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96307567
80GATA3_21867929_ChIP-Seq_TH1_Mouse0.95913016
81SOX2_19829295_ChIP-Seq_ESCs_Human0.94962985
82NANOG_19829295_ChIP-Seq_ESCs_Human0.94962985
83FUS_26573619_Chip-Seq_HEK293_Human0.94760183
84BCL6_27268052_Chip-Seq_Bcells_Human0.93792646
85SA1_27219007_Chip-Seq_Bcells_Human0.93348806
86P300_27268052_Chip-Seq_Bcells_Human0.91233377
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90985973
88IRF8_22096565_ChIP-ChIP_GC-B_Human0.90610745
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.90506358
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89879857
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89862395
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89684353
93REST_21632747_ChIP-Seq_MESCs_Mouse0.89450669
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89448708
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88414693
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88122553
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86994181
98CIITA_25753668_ChIP-Seq_RAJI_Human0.84235669
99E2F1_20622854_ChIP-Seq_HELA_Human0.83937361
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83414977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology5.30296105
2MP0009379_abnormal_foot_pigmentation5.14150092
3MP0006292_abnormal_olfactory_placode4.30173255
4MP0001968_abnormal_touch/_nociception3.46493052
5MP0008877_abnormal_DNA_methylation2.73742730
6MP0002909_abnormal_adrenal_gland2.59754610
7MP0003787_abnormal_imprinting2.56867426
8MP0004147_increased_porphyrin_level2.19575947
9MP0009333_abnormal_splenocyte_physiolog2.08924052
10MP0005671_abnormal_response_to2.08869543
11MP0001905_abnormal_dopamine_level2.00770381
12MP0005646_abnormal_pituitary_gland2.00306672
13MP0006072_abnormal_retinal_apoptosis1.99499640
14MP0008789_abnormal_olfactory_epithelium1.95581671
15MP0002638_abnormal_pupillary_reflex1.92241226
16MP0002163_abnormal_gland_morphology1.92134861
17MP0006276_abnormal_autonomic_nervous1.91594078
18MP0004142_abnormal_muscle_tone1.80942742
19MP0003646_muscle_fatigue1.76320729
20MP0003879_abnormal_hair_cell1.74434936
21MP0002653_abnormal_ependyma_morphology1.64091591
22MP0002736_abnormal_nociception_after1.59581831
23MP0004885_abnormal_endolymph1.58654144
24MP0010386_abnormal_urinary_bladder1.58631970
25MP0003878_abnormal_ear_physiology1.58599584
26MP0005377_hearing/vestibular/ear_phenot1.58599584
27MP0005083_abnormal_biliary_tract1.58459834
28MP0005551_abnormal_eye_electrophysiolog1.42200276
29MP0002876_abnormal_thyroid_physiology1.36440894
30MP0008872_abnormal_physiological_respon1.36265955
31MP0000049_abnormal_middle_ear1.34706668
32MP0008058_abnormal_DNA_repair1.32680151
33MP0005394_taste/olfaction_phenotype1.32442091
34MP0005499_abnormal_olfactory_system1.32442091
35MP0003638_abnormal_response/metabolism_1.29165401
36MP0000372_irregular_coat_pigmentation1.26771524
37MP0002277_abnormal_respiratory_mucosa1.21583610
38MP0003786_premature_aging1.20217363
39MP0005084_abnormal_gallbladder_morpholo1.18887982
40MP0001800_abnormal_humoral_immune1.18507588
41MP0001835_abnormal_antigen_presentation1.17808468
42MP0002138_abnormal_hepatobiliary_system1.17161692
43MP0002837_dystrophic_cardiac_calcinosis1.15187066
44MP0002557_abnormal_social/conspecific_i1.11832976
45MP0009745_abnormal_behavioral_response1.11342536
46MP0002160_abnormal_reproductive_system1.11121408
47MP0005389_reproductive_system_phenotype1.10896063
48MP0004484_altered_response_of1.09466338
49MP0002938_white_spotting1.09257123
50MP0008875_abnormal_xenobiotic_pharmacok1.09250890
51MP0001986_abnormal_taste_sensitivity1.06534170
52MP0003186_abnormal_redox_activity1.06091437
53MP0002148_abnormal_hypersensitivity_rea1.04491382
54MP0003122_maternal_imprinting1.02517618
55MP0005386_behavior/neurological_phenoty1.01911561
56MP0004924_abnormal_behavior1.01911561
57MP0005645_abnormal_hypothalamus_physiol1.01289528
58MP0005085_abnormal_gallbladder_physiolo0.98625609
59MP0000230_abnormal_systemic_arterial0.97851227
60MP0000465_gastrointestinal_hemorrhage0.97233182
61MP0001440_abnormal_grooming_behavior0.97214024
62MP0003011_delayed_dark_adaptation0.97071142
63MP0001963_abnormal_hearing_physiology0.96847445
64MP0003718_maternal_effect0.96481952
65MP0005379_endocrine/exocrine_gland_phen0.96366790
66MP0001293_anophthalmia0.96053382
67MP0005636_abnormal_mineral_homeostasis0.95982703
68MP0002234_abnormal_pharynx_morphology0.95474498
69MP0001919_abnormal_reproductive_system0.94764069
70MP0005448_abnormal_energy_balance0.94331890
71MP0008775_abnormal_heart_ventricle0.93483616
72MP0003121_genomic_imprinting0.93137026
73MP0001765_abnormal_ion_homeostasis0.92909376
74MP0000371_diluted_coat_color0.91907870
75MP0000026_abnormal_inner_ear0.91778537
76MP0002723_abnormal_immune_serum0.91590457
77MP0002272_abnormal_nervous_system0.89261207
78MP0000343_altered_response_to0.89129420
79MP0000639_abnormal_adrenal_gland0.88464512
80MP0001873_stomach_inflammation0.86623330
81MP0005253_abnormal_eye_physiology0.85585923
82MP0001790_abnormal_immune_system0.83523424
83MP0005387_immune_system_phenotype0.83523424
84MP0009053_abnormal_anal_canal0.78187442
85MP0002095_abnormal_skin_pigmentation0.77016909
86MP0003866_abnormal_defecation0.74813095
87MP0001529_abnormal_vocalization0.74584488
88MP0005075_abnormal_melanosome_morpholog0.73768349
89MP0002233_abnormal_nose_morphology0.70636702
90MP0000427_abnormal_hair_cycle0.70138623
91MP0000631_abnormal_neuroendocrine_gland0.68624853
92MP0001502_abnormal_circadian_rhythm0.67978459
93MP0005195_abnormal_posterior_eye0.66288758
94MP0002752_abnormal_somatic_nervous0.65119264
95MP0004145_abnormal_muscle_electrophysio0.64042524
96MP0002075_abnormal_coat/hair_pigmentati0.63987695
97MP0002572_abnormal_emotion/affect_behav0.63746288
98MP0000538_abnormal_urinary_bladder0.63518403
99MP0002184_abnormal_innervation0.62513935
100MP0001984_abnormal_olfaction0.60384615

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.90928524
2Reticulocytopenia (HP:0001896)4.23407258
3Acute necrotizing encephalopathy (HP:0006965)3.97248248
4Symptomatic seizures (HP:0011145)3.94788674
5Abnormality of cells of the erythroid lineage (HP:0012130)3.84368197
6Acute encephalopathy (HP:0006846)3.58332048
7Abnormal mitochondria in muscle tissue (HP:0008316)3.49944550
8Abnormality of midbrain morphology (HP:0002418)3.40363113
9Molar tooth sign on MRI (HP:0002419)3.40363113
10Mitochondrial inheritance (HP:0001427)3.39173318
11Pancreatic fibrosis (HP:0100732)3.30074116
12Macrocytic anemia (HP:0001972)3.27301359
13Abnormal number of erythroid precursors (HP:0012131)3.24574620
14Pancreatic cysts (HP:0001737)3.21492191
15Progressive macrocephaly (HP:0004481)3.20253448
16Asplenia (HP:0001746)3.15821618
17Aplasia/Hypoplasia of the spleen (HP:0010451)3.11665033
18Increased CSF lactate (HP:0002490)3.10221974
19Abnormal rod and cone electroretinograms (HP:0008323)3.02591015
20Lipid accumulation in hepatocytes (HP:0006561)2.98941243
21Pallor (HP:0000980)2.78921565
22IgG deficiency (HP:0004315)2.77624609
23Increased hepatocellular lipid droplets (HP:0006565)2.77612395
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74187860
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74187860
26Increased intramyocellular lipid droplets (HP:0012240)2.73981523
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70427892
28Hepatocellular necrosis (HP:0001404)2.68022495
29Abnormal drinking behavior (HP:0030082)2.66023155
30Polydipsia (HP:0001959)2.66023155
31Pendular nystagmus (HP:0012043)2.64194332
32Medial flaring of the eyebrow (HP:0010747)2.64129769
33Increased muscle lipid content (HP:0009058)2.57502234
34Increased IgM level (HP:0003496)2.57174886
35Abnormality of DNA repair (HP:0003254)2.56909187
36Cerebral edema (HP:0002181)2.53811216
37Congenital stationary night blindness (HP:0007642)2.52666369
38Abnormal protein glycosylation (HP:0012346)2.51825361
39Abnormal glycosylation (HP:0012345)2.51825361
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51825361
41Abnormal protein N-linked glycosylation (HP:0012347)2.51825361
42Nephronophthisis (HP:0000090)2.51310463
433-Methylglutaconic aciduria (HP:0003535)2.48273643
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46339119
45Abnormality of the renal cortex (HP:0011035)2.44631795
46Attenuation of retinal blood vessels (HP:0007843)2.42680637
47Gait imbalance (HP:0002141)2.41749415
48Optic disc pallor (HP:0000543)2.40671448
49Congenital primary aphakia (HP:0007707)2.38542789
50Hepatic necrosis (HP:0002605)2.37735855
51Stomatitis (HP:0010280)2.36853914
52Colon cancer (HP:0003003)2.32853399
53Lactic acidosis (HP:0003128)2.28387391
54Increased serum lactate (HP:0002151)2.27348669
55Abnormality of the renal medulla (HP:0100957)2.27075751
56Type II lissencephaly (HP:0007260)2.26990717
57True hermaphroditism (HP:0010459)2.26409414
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24945121
59Absent thumb (HP:0009777)2.22102454
60Polyuria (HP:0000103)2.20824877
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17983492
62Nephrogenic diabetes insipidus (HP:0009806)2.17618914
63Abolished electroretinogram (ERG) (HP:0000550)2.16635357
64Stenosis of the external auditory canal (HP:0000402)2.13295345
65Elevated erythrocyte sedimentation rate (HP:0003565)2.09999790
66Cystic liver disease (HP:0006706)2.09423488
67Septo-optic dysplasia (HP:0100842)2.08537913
68Renal cortical cysts (HP:0000803)2.01549841
69Enlarged kidneys (HP:0000105)1.98358540
70Decreased circulating renin level (HP:0003351)1.97147371
71Abnormality of the pons (HP:0007361)1.95561290
72Limb dystonia (HP:0002451)1.95095197
73Abnormality of the labia minora (HP:0012880)1.94794161
74Renal Fanconi syndrome (HP:0001994)1.94560464
75Anencephaly (HP:0002323)1.92361806
76Abnormal biliary tract physiology (HP:0012439)1.91728126
77Bile duct proliferation (HP:0001408)1.91728126
78Lethargy (HP:0001254)1.90265306
79Exercise intolerance (HP:0003546)1.89583898
80Supernumerary spleens (HP:0009799)1.84692582
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83631914
82Facial hemangioma (HP:0000329)1.83225963
83Abnormal respiratory motile cilium morphology (HP:0005938)1.82952691
84Abnormal respiratory epithelium morphology (HP:0012253)1.82952691
85Depressed nasal ridge (HP:0000457)1.81372063
86Porencephaly (HP:0002132)1.80706679
87Increased corneal curvature (HP:0100692)1.80078946
88Keratoconus (HP:0000563)1.80078946
89Bony spicule pigmentary retinopathy (HP:0007737)1.76768690
90Abnormal urine output (HP:0012590)1.76622238
91Sclerocornea (HP:0000647)1.76249234
92Poikiloderma (HP:0001029)1.75457749
93Hypoplasia of the radius (HP:0002984)1.75081410
94Hypoplasia of the pons (HP:0012110)1.74581601
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73345883
96Postaxial foot polydactyly (HP:0001830)1.72477418
97Hypoplasia of the ulna (HP:0003022)1.70289699
98Reduced antithrombin III activity (HP:0001976)1.69470016
99Panhypogammaglobulinemia (HP:0003139)1.68517667
100Leukodystrophy (HP:0002415)1.67799493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.90765067
2ADRBK23.57878804
3WNK43.52898212
4STK393.09537945
5BCKDK3.01050199
6TAOK32.53923871
7GRK12.42339505
8TXK2.41369088
9NEK12.20807244
10STK162.16272680
11ZAK2.07100763
12DYRK22.06347434
13NUAK11.84788565
14ABL21.83005081
15VRK21.80174917
16MAP4K21.70043122
17OXSR11.68386945
18MAP2K61.56478377
19NME21.55501792
20PRKD21.51211993
21PDK21.46779875
22FRK1.43664770
23MAP2K21.42731762
24ADRBK11.34523955
25TEC1.21377971
26MAP3K141.20149234
27NME11.16792663
28WNK11.16065429
29PRKCQ1.12571745
30CDK191.10671272
31CAMKK21.09486558
32WNK31.07027566
33LRRK21.06231671
34PASK1.06002598
35BMPR1B1.03581228
36LIMK11.02477861
37IKBKB1.02402197
38NTRK31.01996474
39ERBB21.01621407
40VRK10.96076427
41TBK10.95163072
42FES0.91188111
43TIE10.88357538
44AURKB0.88215313
45RPS6KA50.86798838
46IKBKE0.84931317
47KDR0.84322562
48MAPK130.83385704
49PINK10.83176224
50PHKG10.81361543
51PHKG20.81361543
52DAPK30.80597813
53INSRR0.79594626
54CLK10.76220395
55MST40.72252147
56PRKCG0.71404498
57PIM20.70805086
58CAMK10.69473878
59LYN0.68954024
60LCK0.67355301
61MAP4K10.67154671
62MAP3K110.66214954
63SRPK10.65441819
64ITK0.62299394
65BUB10.60844968
66GRK60.60481207
67PIM10.59423035
68MATK0.56734146
69PIK3CA0.54955830
70PLK30.54222690
71MAPKAPK30.51729586
72PRKACA0.51697673
73EIF2AK20.51589048
74PLK10.51537753
75CSNK2A20.51511112
76CSNK2A10.49811012
77EIF2AK10.48705732
78ATR0.48284914
79MAPKAPK50.48194336
80OBSCN0.46175734
81TAF10.45006596
82RPS6KA60.44778052
83CSNK1E0.44005667
84FGFR20.43423717
85PRKCI0.41218159
86AURKA0.38702445
87BTK0.38059613
88MAP3K120.37511964
89TGFBR10.37312440
90PRKCA0.35930120
91CDC70.35710481
92PBK0.33203594
93PRKCD0.32714084
94CSF1R0.32288799
95MKNK10.31298585
96SYK0.30881939
97CAMK2A0.30692083
98GRK50.30587079
99KIT0.30199589
100CHEK20.29961028

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.16599276
2Sulfur relay system_Homo sapiens_hsa041223.39514434
3Oxidative phosphorylation_Homo sapiens_hsa001903.19273064
4Linoleic acid metabolism_Homo sapiens_hsa005913.11036670
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.07035035
6RNA polymerase_Homo sapiens_hsa030202.57005424
7Parkinsons disease_Homo sapiens_hsa050122.55924393
8Proteasome_Homo sapiens_hsa030502.13393696
9Homologous recombination_Homo sapiens_hsa034401.98313520
10Fat digestion and absorption_Homo sapiens_hsa049751.92469695
11Mismatch repair_Homo sapiens_hsa034301.90911155
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77396268
13Cardiac muscle contraction_Homo sapiens_hsa042601.75468858
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72412866
15Huntingtons disease_Homo sapiens_hsa050161.72110459
16Primary immunodeficiency_Homo sapiens_hsa053401.70772527
17Alzheimers disease_Homo sapiens_hsa050101.69005663
18Nucleotide excision repair_Homo sapiens_hsa034201.65657900
19DNA replication_Homo sapiens_hsa030301.65488857
20Basal transcription factors_Homo sapiens_hsa030221.65125049
21Protein export_Homo sapiens_hsa030601.58524742
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53620103
23One carbon pool by folate_Homo sapiens_hsa006701.52234223
24Arachidonic acid metabolism_Homo sapiens_hsa005901.51573787
25Phototransduction_Homo sapiens_hsa047441.49330860
26Ether lipid metabolism_Homo sapiens_hsa005651.44864623
27Butanoate metabolism_Homo sapiens_hsa006501.43493327
28Pyrimidine metabolism_Homo sapiens_hsa002401.43129163
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40581013
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37529876
31RNA degradation_Homo sapiens_hsa030181.36557448
32Fanconi anemia pathway_Homo sapiens_hsa034601.34692359
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.28993721
34Asthma_Homo sapiens_hsa053101.27725186
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27356418
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18896336
37Peroxisome_Homo sapiens_hsa041461.11209466
38Base excision repair_Homo sapiens_hsa034101.07183067
39Purine metabolism_Homo sapiens_hsa002301.06198387
40Allograft rejection_Homo sapiens_hsa053301.02534823
41Autoimmune thyroid disease_Homo sapiens_hsa053201.00718230
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98944949
43Tryptophan metabolism_Homo sapiens_hsa003800.94828472
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92625363
45Propanoate metabolism_Homo sapiens_hsa006400.89806146
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89370638
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88802328
48Nitrogen metabolism_Homo sapiens_hsa009100.87347932
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87144530
50Chemical carcinogenesis_Homo sapiens_hsa052040.86418621
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85530081
52Caffeine metabolism_Homo sapiens_hsa002320.83829470
53Retinol metabolism_Homo sapiens_hsa008300.78054509
54Spliceosome_Homo sapiens_hsa030400.76034378
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75725798
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74900020
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71328798
58Regulation of autophagy_Homo sapiens_hsa041400.71317977
59Metabolic pathways_Homo sapiens_hsa011000.69815577
60RNA transport_Homo sapiens_hsa030130.69697120
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.68909988
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68503027
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63163583
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.62539757
65Olfactory transduction_Homo sapiens_hsa047400.61040669
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58761116
67Fatty acid degradation_Homo sapiens_hsa000710.58019969
68Nicotine addiction_Homo sapiens_hsa050330.54466640
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.53291330
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.52531600
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51475260
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.51106101
73Steroid biosynthesis_Homo sapiens_hsa001000.48018447
74Graft-versus-host disease_Homo sapiens_hsa053320.47906274
75Type I diabetes mellitus_Homo sapiens_hsa049400.47740275
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47146875
77Folate biosynthesis_Homo sapiens_hsa007900.46233050
78Pancreatic secretion_Homo sapiens_hsa049720.44999503
79Non-homologous end-joining_Homo sapiens_hsa034500.44384232
80Hematopoietic cell lineage_Homo sapiens_hsa046400.43218386
81Fatty acid elongation_Homo sapiens_hsa000620.41084455
82Rheumatoid arthritis_Homo sapiens_hsa053230.40402452
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.38196165
84Collecting duct acid secretion_Homo sapiens_hsa049660.37879147
85Morphine addiction_Homo sapiens_hsa050320.37446286
86T cell receptor signaling pathway_Homo sapiens_hsa046600.36685557
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36552398
88Fatty acid metabolism_Homo sapiens_hsa012120.33986756
89Mineral absorption_Homo sapiens_hsa049780.33199856
90Vitamin B6 metabolism_Homo sapiens_hsa007500.29203536
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27461563
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.27158915
93Arginine and proline metabolism_Homo sapiens_hsa003300.26894064
94Fatty acid biosynthesis_Homo sapiens_hsa000610.24027949
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19190756
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.18993219
97Ovarian steroidogenesis_Homo sapiens_hsa049130.18741034
98N-Glycan biosynthesis_Homo sapiens_hsa005100.18255195
99Starch and sucrose metabolism_Homo sapiens_hsa005000.17872509
100Glycerolipid metabolism_Homo sapiens_hsa005610.17662109

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