RPL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.73575128
2* viral transcription (GO:0019083)9.19666339
3* translational termination (GO:0006415)8.84662340
4ribosomal small subunit biogenesis (GO:0042274)8.49724931
5maturation of SSU-rRNA (GO:0030490)7.60017915
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.58649773
7* translational elongation (GO:0006414)7.57458849
8* cotranslational protein targeting to membrane (GO:0006613)7.44502280
9* protein targeting to ER (GO:0045047)7.42260488
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.08961140
11* protein localization to endoplasmic reticulum (GO:0070972)6.95568110
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.94322119
13* viral life cycle (GO:0019058)6.85495525
14* cellular protein complex disassembly (GO:0043624)6.82418580
15* translational initiation (GO:0006413)6.51402857
16ribosomal large subunit biogenesis (GO:0042273)6.22271846
17* protein complex disassembly (GO:0043241)5.96805959
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.75340791
19* macromolecular complex disassembly (GO:0032984)5.57613917
20* nuclear-transcribed mRNA catabolic process (GO:0000956)5.09886022
21* protein targeting to membrane (GO:0006612)4.91045271
22* mRNA catabolic process (GO:0006402)4.84167361
23ribonucleoprotein complex biogenesis (GO:0022613)4.82114307
24respiratory electron transport chain (GO:0022904)4.74843514
25* translation (GO:0006412)4.65918570
26electron transport chain (GO:0022900)4.65485608
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61120679
28formation of translation preinitiation complex (GO:0001731)4.51022328
29* RNA catabolic process (GO:0006401)4.50175522
30chaperone-mediated protein transport (GO:0072321)4.05197699
31rRNA processing (GO:0006364)3.80522338
32protein complex biogenesis (GO:0070271)3.73870152
33inner mitochondrial membrane organization (GO:0007007)3.69569234
34sequestering of actin monomers (GO:0042989)3.66261314
35rRNA metabolic process (GO:0016072)3.66188884
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65486437
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.65486437
38NADH dehydrogenase complex assembly (GO:0010257)3.65486437
39mitochondrial respiratory chain complex assembly (GO:0033108)3.63929215
40cellular component biogenesis (GO:0044085)3.60186863
41ATP biosynthetic process (GO:0006754)3.50205548
42DNA strand elongation involved in DNA replication (GO:0006271)3.47127912
43telomere maintenance via semi-conservative replication (GO:0032201)3.44272211
44DNA deamination (GO:0045006)3.37542800
45DNA strand elongation (GO:0022616)3.32269253
46oxidative phosphorylation (GO:0006119)3.30827159
47* establishment of protein localization to membrane (GO:0090150)3.28844495
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27233554
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25463422
50protein neddylation (GO:0045116)3.10240833
51hydrogen ion transmembrane transport (GO:1902600)3.08337472
52DNA unwinding involved in DNA replication (GO:0006268)3.08051177
53telomere maintenance via recombination (GO:0000722)3.06145065
54* establishment of protein localization to organelle (GO:0072594)3.00290420
55DNA replication initiation (GO:0006270)2.99808250
56* protein targeting (GO:0006605)2.96473634
57ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96389713
58establishment of integrated proviral latency (GO:0075713)2.92801339
59ribosome biogenesis (GO:0042254)2.90045925
60neuron fate determination (GO:0048664)2.87566596
61mitotic recombination (GO:0006312)2.87201178
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85857150
63regulation of mitochondrial translation (GO:0070129)2.84865041
64intracellular protein transmembrane import (GO:0044743)2.84570796
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84565340
66DNA damage response, detection of DNA damage (GO:0042769)2.84437157
67nucleobase biosynthetic process (GO:0046112)2.82394303
68* protein localization to organelle (GO:0033365)2.81298554
69telomere maintenance via telomere lengthening (GO:0010833)2.78682764
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.78146284
71termination of RNA polymerase III transcription (GO:0006386)2.78146284
72histone exchange (GO:0043486)2.77626816
73spliceosomal snRNP assembly (GO:0000387)2.76520053
74proteasome assembly (GO:0043248)2.74466782
75pseudouridine synthesis (GO:0001522)2.73083682
76termination of RNA polymerase I transcription (GO:0006363)2.72733161
77negative regulation of RNA splicing (GO:0033119)2.72528200
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71596112
79ATP synthesis coupled proton transport (GO:0015986)2.71596112
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.70886686
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70746271
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69859057
83ncRNA processing (GO:0034470)2.68025425
84proton transport (GO:0015992)2.68009959
85spliceosomal complex assembly (GO:0000245)2.67339471
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66929374
87midbrain development (GO:0030901)2.66927712
88centriole replication (GO:0007099)2.66579241
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66161095
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66161095
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65137305
92ncRNA 3-end processing (GO:0043628)2.65012960
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64425131
94transcription-coupled nucleotide-excision repair (GO:0006283)2.63446743
95aerobic respiration (GO:0009060)2.63184382
96CENP-A containing nucleosome assembly (GO:0034080)2.63138990
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63010729
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62882313
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62882313
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62882313
101purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.61705263
102purine nucleoside monophosphate biosynthetic process (GO:0009127)2.61705263
103nucleoside triphosphate biosynthetic process (GO:0009142)2.61552485
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61433399
105negative regulation of ligase activity (GO:0051352)2.61433399
106IMP biosynthetic process (GO:0006188)2.61011941
107hydrogen transport (GO:0006818)2.60915245
108transcription elongation from RNA polymerase I promoter (GO:0006362)2.60789179
109purine nucleobase biosynthetic process (GO:0009113)2.60757122
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.59548262
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59548262
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57962436
113* gene expression (GO:0010467)2.56500066
114viral mRNA export from host cell nucleus (GO:0046784)2.56428000
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56191061
116protein-cofactor linkage (GO:0018065)2.55072634
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.54953258
118definitive hemopoiesis (GO:0060216)2.54661665
119establishment of protein localization to mitochondrion (GO:0072655)2.54518337
120GTP biosynthetic process (GO:0006183)2.54488906
121histone mRNA metabolic process (GO:0008334)2.51770598
122chromatin remodeling at centromere (GO:0031055)2.51724794
123protein localization to mitochondrion (GO:0070585)2.50309722
124ribonucleoprotein complex assembly (GO:0022618)2.49435440
125antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48036034
126* protein localization to membrane (GO:0072657)2.47624132
127protein targeting to mitochondrion (GO:0006626)2.47457817
128ncRNA metabolic process (GO:0034660)2.45382992
129kinetochore assembly (GO:0051382)2.45264886
130kinetochore organization (GO:0051383)2.44787660
131ribosome assembly (GO:0042255)2.43319173
132* cellular component disassembly (GO:0022411)2.42568963
133establishment of viral latency (GO:0019043)2.42195539
134DNA-templated transcription, termination (GO:0006353)2.41792532
135DNA replication-independent nucleosome organization (GO:0034724)2.41771083
136DNA replication-independent nucleosome assembly (GO:0006336)2.41771083
137DNA replication checkpoint (GO:0000076)2.41494511
138RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40933948
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40933948
140primitive streak formation (GO:0090009)2.40881748
141otic vesicle formation (GO:0030916)2.40418930
142RNA splicing, via transesterification reactions (GO:0000375)2.40127940
143mRNA splicing, via spliceosome (GO:0000398)2.39584897
144RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.39584897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.65319928
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.81854281
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02667067
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84225038
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.48196982
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.40239140
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.39525444
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02835753
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01020847
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95777535
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82031421
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81980664
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81132903
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70424092
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67657332
16* XRN2_22483619_ChIP-Seq_HELA_Human2.63374258
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62748681
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60701218
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50349298
20VDR_23849224_ChIP-Seq_CD4+_Human2.48941397
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.36048742
22ELK1_19687146_ChIP-ChIP_HELA_Human2.33552185
23* TTF2_22483619_ChIP-Seq_HELA_Human2.27524186
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26014915
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24957778
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16597065
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13084991
28FOXP3_21729870_ChIP-Seq_TREG_Human2.12918456
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06522635
30DCP1A_22483619_ChIP-Seq_HELA_Human2.03168541
31TP63_17297297_ChIP-ChIP_HaCaT_Human2.02883888
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01052331
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87468054
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85201694
35EWS_26573619_Chip-Seq_HEK293_Human1.84659082
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81372888
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75030715
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70042648
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.68872960
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67226410
41GABP_19822575_ChIP-Seq_HepG2_Human1.64237773
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63680991
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63094192
44* FUS_26573619_Chip-Seq_HEK293_Human1.62923026
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60006193
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.58735957
47CIITA_25753668_ChIP-Seq_RAJI_Human1.56118096
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55422329
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.52699804
50MYC_22102868_ChIP-Seq_BL_Human1.51557740
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.50625161
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50285079
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48318707
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47946069
55* SOX2_16153702_ChIP-ChIP_HESCs_Human1.47824314
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.47470267
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43922696
58VDR_22108803_ChIP-Seq_LS180_Human1.42142333
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40381721
60AR_21909140_ChIP-Seq_LNCAP_Human1.38948586
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38920774
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38091214
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.35748978
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35696618
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35425813
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34349020
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33758027
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.32656952
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32640404
70EZH2_22144423_ChIP-Seq_EOC_Human1.32332170
71* SPI1_23547873_ChIP-Seq_NB4_Human1.32318163
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30354150
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27124392
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.25394549
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22173151
76MYC_18940864_ChIP-ChIP_HL60_Human1.18973091
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18961984
78SCL_19346495_ChIP-Seq_HPC-7_Human1.17884588
79ZNF274_21170338_ChIP-Seq_K562_Hela1.16899722
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.16077776
81VDR_21846776_ChIP-Seq_THP-1_Human1.15827126
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12995124
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12044922
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11745255
85KDM5A_27292631_Chip-Seq_BREAST_Human1.08719545
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07885367
87RNF2_27304074_Chip-Seq_NSC_Mouse1.07445576
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06272039
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05261806
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04495024
91IRF1_19129219_ChIP-ChIP_H3396_Human1.04292491
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04085811
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02686984
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02665673
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02643527
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01774547
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00882165
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00351724
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.99425948
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.99134080
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98436667
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96610370
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96115470
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95295034
105TFEB_21752829_ChIP-Seq_HELA_Human0.93714817
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93164035
107EZH2_27304074_Chip-Seq_ESCs_Mouse0.92345588
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90066397
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89467231
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88501420
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88236825
112MYB_26560356_Chip-Seq_TH2_Human0.88093727
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87401164
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87008601
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86627056
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86038339
117TAF15_26573619_Chip-Seq_HEK293_Human0.85767317
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85432652
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84622430
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79289400
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77795051
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75977675
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.74052974
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72807640
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.71764615
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69482683
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.67713369
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.67022322
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66602324
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.65325972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.60681987
2MP0003693_abnormal_embryo_hatching3.73189944
3MP0004957_abnormal_blastocyst_morpholog3.18883800
4MP0010094_abnormal_chromosome_stability3.00754144
5MP0000566_synostosis2.96410220
6MP0008057_abnormal_DNA_replication2.84940929
7MP0002396_abnormal_hematopoietic_system2.74877000
8MP0003077_abnormal_cell_cycle2.71676075
9MP0003111_abnormal_nucleus_morphology2.42967477
10MP0003283_abnormal_digestive_organ2.25961074
11MP0008007_abnormal_cellular_replicative2.24881771
12MP0008058_abnormal_DNA_repair2.18321011
13MP0003763_abnormal_thymus_physiology2.17046034
14MP0001529_abnormal_vocalization2.13105852
15MP0003890_abnormal_embryonic-extraembry1.98242316
16MP0004808_abnormal_hematopoietic_stem1.95469354
17MP0003941_abnormal_skin_development1.94947502
18MP0003786_premature_aging1.88471216
19MP0000490_abnormal_crypts_of1.87030514
20MP0006054_spinal_hemorrhage1.84274390
21MP0001346_abnormal_lacrimal_gland1.81551221
22MP0001835_abnormal_antigen_presentation1.79230992
23MP0010352_gastrointestinal_tract_polyps1.76971332
24MP0006072_abnormal_retinal_apoptosis1.75347464
25MP0009333_abnormal_splenocyte_physiolog1.63576470
26MP0005174_abnormal_tail_pigmentation1.63373995
27MP0000631_abnormal_neuroendocrine_gland1.62386619
28MP0002166_altered_tumor_susceptibility1.61647637
29MP0002234_abnormal_pharynx_morphology1.61321638
30MP0004142_abnormal_muscle_tone1.61210195
31MP0003123_paternal_imprinting1.60741044
32MP0003880_abnormal_central_pattern1.60493758
33MP0001286_abnormal_eye_development1.56983139
34MP0008932_abnormal_embryonic_tissue1.56511246
35MP0002398_abnormal_bone_marrow1.53638048
36MP0005397_hematopoietic_system_phenotyp1.49129840
37MP0001545_abnormal_hematopoietic_system1.49129840
38MP0002132_abnormal_respiratory_system1.45212177
39MP0005671_abnormal_response_to1.44577740
40MP0002697_abnormal_eye_size1.43319301
41MP0002638_abnormal_pupillary_reflex1.43255156
42MP0003567_abnormal_fetal_cardiomyocyte1.42662030
43MP0002095_abnormal_skin_pigmentation1.41189723
44MP0000703_abnormal_thymus_morphology1.38737518
45MP0002006_tumorigenesis1.37871108
46MP0000350_abnormal_cell_proliferation1.37217439
47MP0002722_abnormal_immune_system1.37005735
48MP0000465_gastrointestinal_hemorrhage1.36943667
49MP0000685_abnormal_immune_system1.34878210
50MP0003315_abnormal_perineum_morphology1.34134972
51MP0001800_abnormal_humoral_immune1.33722779
52MP0004133_heterotaxia1.32825852
53MP0000049_abnormal_middle_ear1.32374554
54MP0001853_heart_inflammation1.30987128
55MP0003937_abnormal_limbs/digits/tail_de1.29832715
56MP0002938_white_spotting1.29502559
57MP0003938_abnormal_ear_development1.29243050
58MP0009785_altered_susceptibility_to1.28667316
59MP0008789_abnormal_olfactory_epithelium1.27742913
60MP0000689_abnormal_spleen_morphology1.25831970
61MP0002420_abnormal_adaptive_immunity1.25643937
62MP0002009_preneoplasia1.25237070
63MP0001819_abnormal_immune_cell1.23381499
64MP0004381_abnormal_hair_follicle1.22633839
65MP0002653_abnormal_ependyma_morphology1.22602194
66MP0005075_abnormal_melanosome_morpholog1.22448559
67MP0002019_abnormal_tumor_incidence1.20883144
68MP0001730_embryonic_growth_arrest1.20653370
69MP0002429_abnormal_blood_cell1.19475183
70MP0003011_delayed_dark_adaptation1.18817866
71MP0000778_abnormal_nervous_system1.18696790
72MP0000716_abnormal_immune_system1.18668295
73MP0003718_maternal_effect1.18523759
74MP0002452_abnormal_antigen_presenting1.18301934
75MP0002102_abnormal_ear_morphology1.17910946
76MP0002163_abnormal_gland_morphology1.17756492
77MP0002210_abnormal_sex_determination1.15023545
78MP0001485_abnormal_pinna_reflex1.14974646
79MP0004742_abnormal_vestibular_system1.12624079
80MP0002822_catalepsy1.10936708
81MP0002148_abnormal_hypersensitivity_rea1.10835360
82MP0002723_abnormal_immune_serum1.10128880
83MP0005084_abnormal_gallbladder_morpholo1.08192862
84MP0010155_abnormal_intestine_physiology1.07739031
85MP0009053_abnormal_anal_canal1.07276679
86MP0000313_abnormal_cell_death1.06179512
87MP0002405_respiratory_system_inflammati1.04825271
88MP0005025_abnormal_response_to1.04346227
89MP0000026_abnormal_inner_ear1.03934665
90MP0009697_abnormal_copulation1.03199319
91MP0002796_impaired_skin_barrier1.02980556
92MP0005000_abnormal_immune_tolerance1.02034594
93MP0005501_abnormal_skin_physiology1.01871294
94MP0000858_altered_metastatic_potential1.00402225
95MP0005394_taste/olfaction_phenotype0.98853104
96MP0005499_abnormal_olfactory_system0.98853104
97MP0002233_abnormal_nose_morphology0.98525860
98MP0001873_stomach_inflammation0.97908149
99MP0006035_abnormal_mitochondrial_morpho0.97856447
100MP0002751_abnormal_autonomic_nervous0.97680905
101MP0000372_irregular_coat_pigmentation0.96460875
102MP0001697_abnormal_embryo_size0.95525007
103MP0003119_abnormal_digestive_system0.94275873
104MP0003121_genomic_imprinting0.94003853
105MP0000537_abnormal_urethra_morphology0.93696188
106MP0002080_prenatal_lethality0.93504110
107MP0003436_decreased_susceptibility_to0.92706060
108MP0005391_vision/eye_phenotype0.91984222
109MP0004147_increased_porphyrin_level0.90502963
110MP0002160_abnormal_reproductive_system0.89927902
111MP0008995_early_reproductive_senescence0.89237568
112MP0006276_abnormal_autonomic_nervous0.89174615
113MP0001216_abnormal_epidermal_layer0.89069496
114MP0008877_abnormal_DNA_methylation0.88671563
115MP0003866_abnormal_defecation0.88668657
116MP0001145_abnormal_male_reproductive0.87905757
117MP0005187_abnormal_penis_morphology0.86648359
118MP0002837_dystrophic_cardiac_calcinosis0.86414015
119MP0003806_abnormal_nucleotide_metabolis0.85955116
120MP0003136_yellow_coat_color0.83588879
121MP0000383_abnormal_hair_follicle0.83251737
122MP0001672_abnormal_embryogenesis/_devel0.83136308
123MP0005380_embryogenesis_phenotype0.83136308
124MP0002086_abnormal_extraembryonic_tissu0.83111769
125MP0005253_abnormal_eye_physiology0.82721051
126MP0001929_abnormal_gametogenesis0.82651274
127MP0002060_abnormal_skin_morphology0.82614883
128MP0000653_abnormal_sex_gland0.82033056
129MP0001879_abnormal_lymphatic_vessel0.82010105
130MP0006292_abnormal_olfactory_placode0.81813909
131MP0002098_abnormal_vibrissa_morphology0.81540147
132MP0005423_abnormal_somatic_nervous0.81018880
133MP0009250_abnormal_appendicular_skeleto0.80621544
134MP0002111_abnormal_tail_morphology0.79736945
135MP0005195_abnormal_posterior_eye0.79703805
136MP0002277_abnormal_respiratory_mucosa0.79479582
137MP0010030_abnormal_orbit_morphology0.79474433
138MP0001324_abnormal_eye_pigmentation0.79364928
139MP0005409_darkened_coat_color0.78956730
140MP0003861_abnormal_nervous_system0.78134695
141MP0003186_abnormal_redox_activity0.77007942
142MP0001293_anophthalmia0.76939240
143MP0002092_abnormal_eye_morphology0.76670513
144MP0010234_abnormal_vibrissa_follicle0.76503719
145MP0002084_abnormal_developmental_patter0.76501200
146MP0005387_immune_system_phenotype0.76498926
147MP0001790_abnormal_immune_system0.76498926
148MP0002736_abnormal_nociception_after0.76243124
149MP0004197_abnormal_fetal_growth/weight/0.75695961
150MP0002085_abnormal_embryonic_tissue0.75106638
151MP0006036_abnormal_mitochondrial_physio0.75040701
152MP0005464_abnormal_platelet_physiology0.74992526
153MP0002282_abnormal_trachea_morphology0.74410211
154MP0003755_abnormal_palate_morphology0.74294176
155MP0003984_embryonic_growth_retardation0.73704194
156MP0005023_abnormal_wound_healing0.73645634
157MP0002088_abnormal_embryonic_growth/wei0.73277009
158MP0002928_abnormal_bile_duct0.72500893
159MP0001188_hyperpigmentation0.72212408
160MP0005551_abnormal_eye_electrophysiolog0.71892381
161MP0010307_abnormal_tumor_latency0.71542014
162MP0002752_abnormal_somatic_nervous0.71096209
163MP0001905_abnormal_dopamine_level0.70842603
164MP0004885_abnormal_endolymph0.70683920
165MP0000477_abnormal_intestine_morphology0.69039320
166MP0004145_abnormal_muscle_electrophysio0.68154723
167MP0005171_absent_coat_pigmentation0.67008679
168MP0000762_abnormal_tongue_morphology0.65332920
169MP0003698_abnormal_male_reproductive0.64882819

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.01725013
2Abnormal number of erythroid precursors (HP:0012131)8.05472372
3Reticulocytopenia (HP:0001896)7.89654529
4Macrocytic anemia (HP:0001972)5.59077067
5Pallor (HP:0000980)5.31161294
6Abnormal mitochondria in muscle tissue (HP:0008316)4.10467774
7Thrombocytosis (HP:0001894)3.95287477
8Acute encephalopathy (HP:0006846)3.95220280
9Colon cancer (HP:0003003)3.83661843
10Aplastic anemia (HP:0001915)3.75367654
11Progressive macrocephaly (HP:0004481)3.69496646
1211 pairs of ribs (HP:0000878)3.67934160
13Septo-optic dysplasia (HP:0100842)3.56998773
14Hepatic necrosis (HP:0002605)3.04828364
15Congenital, generalized hypertrichosis (HP:0004540)3.02138094
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00900809
17Stenosis of the external auditory canal (HP:0000402)2.94645257
18IgM deficiency (HP:0002850)2.94359083
19Cerebral edema (HP:0002181)2.83940383
20Increased intramyocellular lipid droplets (HP:0012240)2.75227193
21Birth length less than 3rd percentile (HP:0003561)2.71652893
22Abnormal hemoglobin (HP:0011902)2.70268088
23Absent thumb (HP:0009777)2.69273373
24Maternal diabetes (HP:0009800)2.61717316
25Depressed nasal ridge (HP:0000457)2.61335947
26Oral leukoplakia (HP:0002745)2.56662217
27Increased hepatocellular lipid droplets (HP:0006565)2.50941708
28Absent septum pellucidum (HP:0001331)2.48891489
29Asplenia (HP:0001746)2.40313950
30Optic disc pallor (HP:0000543)2.39943538
31Bilateral microphthalmos (HP:0007633)2.39466831
32Abnormality of the parietal bone (HP:0002696)2.39340591
33Leukodystrophy (HP:0002415)2.38702509
34Abnormality of reticulocytes (HP:0004312)2.36396517
35Esophageal atresia (HP:0002032)2.34999522
36Pancreatic fibrosis (HP:0100732)2.34755941
37Myelodysplasia (HP:0002863)2.32958224
38Pancreatic cysts (HP:0001737)2.31354343
39Molar tooth sign on MRI (HP:0002419)2.28698374
40Abnormality of midbrain morphology (HP:0002418)2.28698374
41Respiratory difficulties (HP:0002880)2.26105795
42Exertional dyspnea (HP:0002875)2.25758397
43Duplication of thumb phalanx (HP:0009942)2.25370054
44Glossoptosis (HP:0000162)2.23530364
45Abnormality of renal resorption (HP:0011038)2.21902505
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.21194769
47Increased muscle lipid content (HP:0009058)2.17923447
48True hermaphroditism (HP:0010459)2.17828445
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.17331837
50Selective tooth agenesis (HP:0001592)2.16061422
51Rough bone trabeculation (HP:0100670)2.15093980
52Abnormality of the pons (HP:0007361)2.14975264
53Migraine (HP:0002076)2.13279950
54Missing ribs (HP:0000921)2.12572762
55Hypoplasia of the pons (HP:0012110)2.12064799
56Elevated erythrocyte sedimentation rate (HP:0003565)2.11550010
57Increased serum lactate (HP:0002151)2.09454249
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09016394
59Abnormality of the septum pellucidum (HP:0007375)2.08904723
60Thick lower lip vermilion (HP:0000179)2.08550051
61Multiple enchondromatosis (HP:0005701)2.08271423
62Lactic acidosis (HP:0003128)2.08163962
63Anophthalmia (HP:0000528)2.07556441
64Trismus (HP:0000211)2.07291515
65Chronic otitis media (HP:0000389)2.06775831
66Concave nail (HP:0001598)2.05524222
67Meckel diverticulum (HP:0002245)2.04997440
68Abnormality of the labia minora (HP:0012880)2.03770016
69Lipid accumulation in hepatocytes (HP:0006561)2.03525653
70Lymphoma (HP:0002665)2.02661246
71Nephronophthisis (HP:0000090)2.02031702
72Premature graying of hair (HP:0002216)2.02026246
73Rib fusion (HP:0000902)2.01957224
74Petechiae (HP:0000967)2.00700034
75Medial flaring of the eyebrow (HP:0010747)1.99512465
76Hypoplasia of the radius (HP:0002984)1.99268515
77Respiratory failure (HP:0002878)1.99124737
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99103331
79Cleft eyelid (HP:0000625)1.98740132
80Basal cell carcinoma (HP:0002671)1.98069766
81Abnormality of the ileum (HP:0001549)1.97570997
82Exercise intolerance (HP:0003546)1.97430088
83Woolly hair (HP:0002224)1.97302976
84Gastrointestinal atresia (HP:0002589)1.94571927
85Type I transferrin isoform profile (HP:0003642)1.94543176
86Breast hypoplasia (HP:0003187)1.94326788
87Amaurosis fugax (HP:0100576)1.93415305
88Optic nerve hypoplasia (HP:0000609)1.93274235
89Sclerocornea (HP:0000647)1.93126108
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92927243
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92927243
92Microretrognathia (HP:0000308)1.91240768
93Triphalangeal thumb (HP:0001199)1.91117488
94Partial duplication of thumb phalanx (HP:0009944)1.90200634
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89135709
96Recurrent bronchitis (HP:0002837)1.88507452
97Duplicated collecting system (HP:0000081)1.88342487
98IgG deficiency (HP:0004315)1.87376355
99Mitochondrial inheritance (HP:0001427)1.85119853
100Cellular immunodeficiency (HP:0005374)1.83293460
101Glycosuria (HP:0003076)1.83036639
102Abnormality of urine glucose concentration (HP:0011016)1.83036639
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82626358
104Agnosia (HP:0010524)1.82205230
105Carpal bone hypoplasia (HP:0001498)1.81213452
106Atresia of the external auditory canal (HP:0000413)1.80650530
107Poikiloderma (HP:0001029)1.80490995
108Muscle fiber atrophy (HP:0100295)1.79953150
109Abnormality of the axillary hair (HP:0100134)1.79654544
110Abnormality of secondary sexual hair (HP:0009888)1.79654544
111Hyperphosphaturia (HP:0003109)1.78284855
112Neoplasm of the pancreas (HP:0002894)1.77432098
113Partial duplication of the phalanx of hand (HP:0009999)1.76970162
114Renal Fanconi syndrome (HP:0001994)1.76566181
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75889243
116Abnormality of the preputium (HP:0100587)1.74423198
117Anencephaly (HP:0002323)1.74403285
118Medulloblastoma (HP:0002885)1.74393018
119Patellar aplasia (HP:0006443)1.74114796
120Squamous cell carcinoma (HP:0002860)1.73353022
121Optic nerve coloboma (HP:0000588)1.72398672
122Sparse eyelashes (HP:0000653)1.72045825
123Abnormality of T cells (HP:0002843)1.71806593
124Abnormal number of incisors (HP:0011064)1.71675401
125Abnormality of T cell physiology (HP:0011840)1.71391332
126Abnormality of the renal collecting system (HP:0004742)1.71127241
127Abnormal lung lobation (HP:0002101)1.70515598
128Acute necrotizing encephalopathy (HP:0006965)1.69852920
129B lymphocytopenia (HP:0010976)1.69624039
130Abnormality of B cell number (HP:0010975)1.69624039
131Abnormality of the anterior horn cell (HP:0006802)1.66525223
132Degeneration of anterior horn cells (HP:0002398)1.66525223
133Hypoproteinemia (HP:0003075)1.66476273
134Pancytopenia (HP:0001876)1.66058897
135Abnormal respiratory motile cilium physiology (HP:0012261)1.65492062
136Type II lissencephaly (HP:0007260)1.65262981
137Aplasia/Hypoplasia of the patella (HP:0006498)1.65154283
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.63759594
139Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62629817
140Congenital primary aphakia (HP:0007707)1.62482191
141Morphological abnormality of the inner ear (HP:0011390)1.62234291
142Panhypogammaglobulinemia (HP:0003139)1.61861104
143Abnormal ciliary motility (HP:0012262)1.60899372
144Microvesicular hepatic steatosis (HP:0001414)1.60845751
145Abnormality of chromosome stability (HP:0003220)1.59687723
146Duodenal stenosis (HP:0100867)1.59366122
147Small intestinal stenosis (HP:0012848)1.59366122
1483-Methylglutaconic aciduria (HP:0003535)1.57825297
149Increased CSF lactate (HP:0002490)1.57314609
150Entropion (HP:0000621)1.54718503
151Chromsome breakage (HP:0040012)1.53967793
152Bicuspid aortic valve (HP:0001647)1.52293254
153Type 2 muscle fiber atrophy (HP:0003554)1.52147805
154Abnormal trabecular bone morphology (HP:0100671)1.50251437
155Recurrent viral infections (HP:0004429)1.49713398
156Hepatocellular necrosis (HP:0001404)1.49562261
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.49149841
158Lip pit (HP:0100267)1.48713037
159Horseshoe kidney (HP:0000085)1.48223339
160Abnormality of cells of the lymphoid lineage (HP:0012140)1.48114384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.53975147
2VRK24.36479804
3PNCK3.72390534
4WEE13.43493198
5TGFBR13.09022556
6BUB12.94029715
7RPS6KB22.85129884
8PASK2.67979017
9MAPK152.51346447
10SRPK12.47155361
11STK162.39073779
12MST42.32626484
13LRRK22.30219802
14VRK12.27793808
15EEF2K2.12276849
16CDC72.07283732
17MAP4K11.93732361
18TSSK61.93476688
19TAF11.90652569
20PIM21.84905085
21BRSK21.77991505
22EPHB21.77085985
23MKNK11.76670008
24DYRK21.71144299
25DYRK31.62545949
26TNIK1.61919525
27ACVR1B1.61419916
28EIF2AK11.57647393
29PBK1.51663306
30EIF2AK31.49875058
31TLK11.49498890
32TEC1.46398588
33FLT31.45848141
34AURKB1.44532081
35WNK31.40772643
36BTK1.40571710
37RPS6KA41.39114511
38NEK11.35322404
39MAP3K31.33544721
40CDK71.29943778
41MAP2K31.23666817
42KIT1.20904557
43NEK21.16587062
44ILK1.15873654
45STK101.14932577
46ATR1.14328219
47MAP3K101.13699811
48PIM11.12908297
49MAPKAPK31.10071554
50KDR1.07038759
51TXK1.05056957
52PLK11.04715915
53ZAP700.98260644
54MAP3K120.97757384
55INSRR0.97298387
56PAK40.96849043
57ZAK0.95967810
58PLK30.93685477
59CDK190.88111994
60JAK30.86700795
61IKBKB0.86681622
62NME10.86308287
63CDK30.86141473
64ADRBK20.84953350
65MKNK20.84852736
66PLK40.84762082
67CDK80.84101826
68CASK0.83676466
69SYK0.79910739
70NLK0.77776565
71CSNK2A20.77634608
72EPHA20.76622297
73CDK40.74373770
74TYK20.73385728
75PRKCG0.72729693
76MAP3K80.71619846
77IRAK40.71315256
78WNK40.71214108
79MYLK0.70606009
80RPS6KA50.68850960
81ITK0.68719438
82STK240.68703785
83GRK60.68236765
84EIF2AK20.67371161
85TGFBR20.67270590
86CSNK2A10.67094206
87FGFR20.66324765
88MAPKAPK50.63860252
89MAP3K40.63496361
90STK40.63393205
91AURKA0.63075272
92GRK10.62210736
93TTK0.61839737
94CHEK10.59495241
95STK30.58806937
96BMPR1B0.58768439
97BCKDK0.57859227
98PKN20.57791979
99CHEK20.56361797
100CSF1R0.56258964
101DAPK30.55615492
102LCK0.54628356
103UHMK10.54595713
104BRSK10.54588658
105TESK20.54311225
106CDK60.54303353
107EPHA40.53720079
108TYRO30.53691570
109LYN0.53091599
110MAP2K60.53072347
111IKBKE0.52937909
112TIE10.50662528
113NUAK10.49013364
114CSNK1E0.47513267
115ATM0.47459316
116CLK10.47130302
117BLK0.45910341
118CCNB10.45728692
119MATK0.45245154
120TAOK30.45178707
121NTRK20.43114998
122RPS6KA60.41567204
123RPS6KC10.40419947
124RPS6KL10.40419947
125MAP4K20.39853166
126PAK20.38745430
127ADRBK10.38293621
128MAPKAPK20.37868987
129YES10.37226465
130TBK10.36322079
131PRKCI0.36309817
132CDK20.36248435
133FGFR10.35480047
134MAPK130.33467391
135PDK20.32563504
136PINK10.30369309
137CDK10.30304823
138DYRK1A0.27441572
139BRAF0.27219854
140MUSK0.26712212
141PRKACA0.24963439
142PRKDC0.23407054
143PRKACB0.23373416
144CSNK1A10.22812415
145OXSR10.22288459
146STK390.21454918

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.22413081
2DNA replication_Homo sapiens_hsa030303.82709664
3Proteasome_Homo sapiens_hsa030503.35181901
4Mismatch repair_Homo sapiens_hsa034303.33941450
5RNA polymerase_Homo sapiens_hsa030203.18222563
6Spliceosome_Homo sapiens_hsa030402.98108219
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68346350
8Nucleotide excision repair_Homo sapiens_hsa034202.44324899
9Base excision repair_Homo sapiens_hsa034102.38547423
10Homologous recombination_Homo sapiens_hsa034402.30527312
11RNA transport_Homo sapiens_hsa030132.25012451
12Cardiac muscle contraction_Homo sapiens_hsa042602.22690391
13Pyrimidine metabolism_Homo sapiens_hsa002402.21812303
14Non-homologous end-joining_Homo sapiens_hsa034501.83641713
15Protein export_Homo sapiens_hsa030601.76733373
16RNA degradation_Homo sapiens_hsa030181.74778760
17Cell cycle_Homo sapiens_hsa041101.71223790
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63117915
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59299251
20Primary immunodeficiency_Homo sapiens_hsa053401.50512516
21Fanconi anemia pathway_Homo sapiens_hsa034601.49305869
22Basal transcription factors_Homo sapiens_hsa030221.49151270
23One carbon pool by folate_Homo sapiens_hsa006701.43626061
24Parkinsons disease_Homo sapiens_hsa050121.38765925
25p53 signaling pathway_Homo sapiens_hsa041151.35531173
26Oxidative phosphorylation_Homo sapiens_hsa001901.30974918
27Antigen processing and presentation_Homo sapiens_hsa046121.17220271
28Huntingtons disease_Homo sapiens_hsa050161.14651125
29Purine metabolism_Homo sapiens_hsa002301.13408948
30Epstein-Barr virus infection_Homo sapiens_hsa051691.13395474
31mRNA surveillance pathway_Homo sapiens_hsa030151.11589974
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.07868832
33Herpes simplex infection_Homo sapiens_hsa051681.02367582
34Systemic lupus erythematosus_Homo sapiens_hsa053220.96026269
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92082224
36Hematopoietic cell lineage_Homo sapiens_hsa046400.90169201
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85106706
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82289124
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79467244
40Alzheimers disease_Homo sapiens_hsa050100.78184374
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.77552868
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76855735
43Viral carcinogenesis_Homo sapiens_hsa052030.74933847
44HTLV-I infection_Homo sapiens_hsa051660.74716330
45Measles_Homo sapiens_hsa051620.74033396
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.73489744
47Legionellosis_Homo sapiens_hsa051340.73251781
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.72533890
49Pyruvate metabolism_Homo sapiens_hsa006200.72220482
50Allograft rejection_Homo sapiens_hsa053300.72096511
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72069687
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69244321
53Hedgehog signaling pathway_Homo sapiens_hsa043400.69034635
54Phototransduction_Homo sapiens_hsa047440.65340436
55Linoleic acid metabolism_Homo sapiens_hsa005910.64727344
56Propanoate metabolism_Homo sapiens_hsa006400.63474817
57Thyroid cancer_Homo sapiens_hsa052160.62859261
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.62509914
59Selenocompound metabolism_Homo sapiens_hsa004500.61959586
60Nitrogen metabolism_Homo sapiens_hsa009100.60484712
61Metabolic pathways_Homo sapiens_hsa011000.58674662
62Small cell lung cancer_Homo sapiens_hsa052220.58180184
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55798895
64N-Glycan biosynthesis_Homo sapiens_hsa005100.53636478
65Asthma_Homo sapiens_hsa053100.51249215
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.51161080
67Apoptosis_Homo sapiens_hsa042100.50478576
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50475299
69Graft-versus-host disease_Homo sapiens_hsa053320.50065718
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49870733
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48726440
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48304968
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47542136
74Leishmaniasis_Homo sapiens_hsa051400.47503101
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47402908
76Hepatitis B_Homo sapiens_hsa051610.46765244
77Nicotine addiction_Homo sapiens_hsa050330.44655812
78T cell receptor signaling pathway_Homo sapiens_hsa046600.44551679
79Shigellosis_Homo sapiens_hsa051310.44397143
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43593154
81B cell receptor signaling pathway_Homo sapiens_hsa046620.43046086
82Glutathione metabolism_Homo sapiens_hsa004800.42443785
83Butanoate metabolism_Homo sapiens_hsa006500.42174958
84Notch signaling pathway_Homo sapiens_hsa043300.41750801
85Arachidonic acid metabolism_Homo sapiens_hsa005900.40993018
86MicroRNAs in cancer_Homo sapiens_hsa052060.40197042
87Basal cell carcinoma_Homo sapiens_hsa052170.39737134
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39377425
89Alcoholism_Homo sapiens_hsa050340.38622109
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38557011
91Vitamin digestion and absorption_Homo sapiens_hsa049770.38327367
92Caffeine metabolism_Homo sapiens_hsa002320.37964851
93TGF-beta signaling pathway_Homo sapiens_hsa043500.37786111
94Autoimmune thyroid disease_Homo sapiens_hsa053200.37590971
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37081309
96Influenza A_Homo sapiens_hsa051640.35548814
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.34489250
98Folate biosynthesis_Homo sapiens_hsa007900.34042825
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33798987
100Acute myeloid leukemia_Homo sapiens_hsa052210.33713030
101Olfactory transduction_Homo sapiens_hsa047400.33587494
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33576251
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33479954
104Pathways in cancer_Homo sapiens_hsa052000.33140336
105Toxoplasmosis_Homo sapiens_hsa051450.32704101
106Sulfur relay system_Homo sapiens_hsa041220.32369014
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32294857
108Viral myocarditis_Homo sapiens_hsa054160.31405064
109Colorectal cancer_Homo sapiens_hsa052100.31154316
110Wnt signaling pathway_Homo sapiens_hsa043100.30305874
111Peroxisome_Homo sapiens_hsa041460.30122141
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29528522
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29254252
114Platelet activation_Homo sapiens_hsa046110.28312653
115Chronic myeloid leukemia_Homo sapiens_hsa052200.27465700
116Chemical carcinogenesis_Homo sapiens_hsa052040.27041427
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26873952
118Oocyte meiosis_Homo sapiens_hsa041140.26179517
119HIF-1 signaling pathway_Homo sapiens_hsa040660.25506197
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.24986366
121Pentose phosphate pathway_Homo sapiens_hsa000300.24467199
122Tryptophan metabolism_Homo sapiens_hsa003800.24410856
123Steroid biosynthesis_Homo sapiens_hsa001000.24397415
124Fat digestion and absorption_Homo sapiens_hsa049750.24045632
125Taste transduction_Homo sapiens_hsa047420.22870545
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22402442
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21785189
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21702204
129Pertussis_Homo sapiens_hsa051330.20552936
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19703438
131Malaria_Homo sapiens_hsa051440.17999721
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17218712
133Collecting duct acid secretion_Homo sapiens_hsa049660.17016823
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16392366
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15546539
136Regulation of autophagy_Homo sapiens_hsa041400.14191086
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13948670
138Ether lipid metabolism_Homo sapiens_hsa005650.13800970
139Retinol metabolism_Homo sapiens_hsa008300.13613359
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12906574
141Fatty acid elongation_Homo sapiens_hsa000620.12657989
142Hippo signaling pathway_Homo sapiens_hsa043900.12321218
143Tyrosine metabolism_Homo sapiens_hsa003500.12258902
144Type I diabetes mellitus_Homo sapiens_hsa049400.12046991
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.10065846
146Carbon metabolism_Homo sapiens_hsa012000.10053519
147Biosynthesis of amino acids_Homo sapiens_hsa012300.09075050

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