ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of respiratory burst (GO:0060267)	8.49201486
2	eosinophil chemotaxis (GO:0048245)	7.44067295
3	eosinophil migration (GO:0072677)	6.64025831
4	antibacterial humoral response (GO:0019731)	6.49526481
5	positive regulation of glycoprotein biosynthetic process (GO:0010560)	6.47194713
6	regulation of cellular extravasation (GO:0002691)	6.28708003
7	antimicrobial humoral response (GO:0019730)	6.07184874
8	glomerular filtration (GO:0003094)	6.05917439
9	regulation of respiratory burst (GO:0060263)	5.98445584
10	regulation of guanylate cyclase activity (GO:0031282)	5.54719824
11	positive regulation of glycoprotein metabolic process (GO:1903020)	5.42673329
12	renal filtration (GO:0097205)	5.34509197
13	positive regulation of fatty acid beta-oxidation (GO:0032000)	5.08772899
14	positive regulation of guanylate cyclase activity (GO:0031284)	4.87749557
15	negative regulation of epidermal cell differentiation (GO:0045605)	4.71311920
16	positive regulation of fatty acid oxidation (GO:0046321)	4.28890445
17	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.22248889
18	killing of cells of other organism (GO:0031640)	4.19441960
19	disruption of cells of other organism (GO:0044364)	4.19441960
20	complement activation, classical pathway (GO:0006958)	4.18389431
21	chronic inflammatory response (GO:0002544)	4.12165842
22	angiotensin maturation (GO:0002003)	4.10440261
23	positive regulation of microtubule polymerization (GO:0031116)	4.07479274
24	NADH metabolic process (GO:0006734)	3.97716677
25	L-fucose catabolic process (GO:0042355)	3.79833980
26	fucose catabolic process (GO:0019317)	3.79833980
27	L-fucose metabolic process (GO:0042354)	3.79833980
28	arginine metabolic process (GO:0006525)	3.78276415
29	negative regulation of epidermis development (GO:0045683)	3.78265825
30	neuron fate determination (GO:0048664)	3.69792761
31	cerebral cortex radially oriented cell migration (GO:0021799)	3.67843178
32	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	3.65319975
33	fructose metabolic process (GO:0006000)	3.60238000
34	muscle cell cellular homeostasis (GO:0046716)	3.58512637
35	negative regulation of leukocyte migration (GO:0002686)	3.53967897
36	regulation of keratinocyte differentiation (GO:0045616)	3.53782446
37	regulation of cGMP biosynthetic process (GO:0030826)	3.50020548
38	startle response (GO:0001964)	3.43178716
39	GDP-mannose metabolic process (GO:0019673)	3.41403773
40	vitamin A metabolic process (GO:0006776)	3.41367269
41	regulation of keratinocyte proliferation (GO:0010837)	3.41303395
42	defense response to fungus (GO:0050832)	3.39486046
43	cytoplasmic microtubule organization (GO:0031122)	3.39355549
44	regulation of cGMP metabolic process (GO:0030823)	3.37691989
45	arginine catabolic process (GO:0006527)	3.36350516
46	intestinal absorption (GO:0050892)	3.34652698
47	cellular response to zinc ion (GO:0071294)	3.33929772
48	branching involved in mammary gland duct morphogenesis (GO:0060444)	3.30456563
49	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.29708082
50	fucosylation (GO:0036065)	3.24747134
51	complement activation (GO:0006956)	3.17683779
52	negative regulation of leukocyte chemotaxis (GO:0002689)	3.16260885
53	retina homeostasis (GO:0001895)	3.11813480
54	exogenous drug catabolic process (GO:0042738)	3.11079018
55	neuronal action potential propagation (GO:0019227)	3.07684511
56	digestion (GO:0007586)	3.07086134
57	drug catabolic process (GO:0042737)	3.01613710
58	parental behavior (GO:0060746)	3.00389335
59	midgut development (GO:0007494)	2.99759681
60	negative regulation of keratinocyte proliferation (GO:0010839)	2.98592135
61	ERK1 and ERK2 cascade (GO:0070371)	2.97754150
62	positive regulation of cGMP biosynthetic process (GO:0030828)	2.97722092
63	cellular response to cadmium ion (GO:0071276)	2.97569779
64	drug metabolic process (GO:0017144)	2.96995010
65	skeletal muscle fiber development (GO:0048741)	2.96821375
66	transcytosis (GO:0045056)	2.96384731
67	neurotransmitter catabolic process (GO:0042135)	2.94773630
68	alkaloid metabolic process (GO:0009820)	2.92942109
69	diacylglycerol metabolic process (GO:0046339)	2.90875112
70	maternal behavior (GO:0042711)	2.89265051
71	positive regulation of meiosis (GO:0045836)	2.88903323
72	positive regulation of meiotic cell cycle (GO:0051446)	2.84480822
73	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.83358967
74	regulation of glycogen (starch) synthase activity (GO:2000465)	2.79913391
75	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.77193796
76	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.76764537
77	glycerol metabolic process (GO:0006071)	2.74993479
78	fucose metabolic process (GO:0006004)	2.73947852
79	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.73041068
80	oligosaccharide biosynthetic process (GO:0009312)	2.70455108
81	cytidine catabolic process (GO:0006216)	2.68272424
82	cytidine deamination (GO:0009972)	2.68272424
83	cytidine metabolic process (GO:0046087)	2.68272424
84	positive regulation of cGMP metabolic process (GO:0030825)	2.64429418
85	C4-dicarboxylate transport (GO:0015740)	2.63789670
86	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.63589442
87	hormone catabolic process (GO:0042447)	2.63459990
88	multicellular organismal reproductive behavior (GO:0033057)	2.63411124
89	neurotransmitter metabolic process (GO:0042133)	2.61654612
90	myotube cell development (GO:0014904)	2.60138633
91	vitamin transport (GO:0051180)	2.58547370
92	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.58051256
93	sodium ion export (GO:0071436)	2.56248680
94	positive regulation of lipid catabolic process (GO:0050996)	2.55991117
95	regulation of glycoprotein biosynthetic process (GO:0010559)	2.52741988
96	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.51157492
97	positive regulation of protein targeting to membrane (GO:0090314)	2.50310403
98	adaptation of signaling pathway (GO:0023058)	2.49655640
99	positive regulation of pseudopodium assembly (GO:0031274)	11.2591839
100	regulation of pseudopodium assembly (GO:0031272)	10.4602905

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	6.80605634
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.61596524
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.74525686
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.68610470
5	RXR_22108803_ChIP-Seq_LS180_Human	2.52690797
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.43137891
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.21699432
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16117369
9	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.04359044
10	BCAT_22108803_ChIP-Seq_LS180_Human	1.96954776
11	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.96492358
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.88290472
13	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.81027960
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.80574036
15	TP53_16413492_ChIP-PET_HCT116_Human	1.71046787
16	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.70443826
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66403652
18	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.61738569
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57162362
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52759214
21	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.52058684
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51171342
23	GATA4_25053715_ChIP-Seq_YYC3_Human	1.48852933
24	VDR_22108803_ChIP-Seq_LS180_Human	1.45955964
25	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40448532
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.38814887
27	TCF4_22108803_ChIP-Seq_LS180_Human	1.36640604
28	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.36348193
29	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.35716845
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.34803688
31	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31598544
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31441589
33	AR_25329375_ChIP-Seq_VCAP_Human	1.27462745
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27088466
35	STAT3_23295773_ChIP-Seq_U87_Human	1.25756684
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.24090228
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.22955780
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20361479
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19217030
40	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.17217153
41	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17137623
42	MYC_19829295_ChIP-Seq_ESCs_Human	1.16929303
43	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.16376147
44	CTCF_27219007_Chip-Seq_Bcells_Human	1.15519544
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14323920
46	STAT1_20625510_ChIP-Seq_HELA_Human	1.13894295
47	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13725983
48	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11706679
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.10839586
50	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10544201
51	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.10135992
52	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.09912709
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09619134
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08744869
55	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08577233
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.08312633
57	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.07970950
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07096104
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07096104
60	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.06916463
61	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06365971
62	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04955072
63	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.04275540
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03957096
65	AR_20517297_ChIP-Seq_VCAP_Human	1.03235801
66	P300_19829295_ChIP-Seq_ESCs_Human	1.02091831
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00770222
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99675882
69	ER_23166858_ChIP-Seq_MCF-7_Human	0.99562932
70	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.99358536
71	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98846211
72	SOX2_21211035_ChIP-Seq_LN229_Human	0.98124642
73	SOX2_20726797_ChIP-Seq_SW620_Human	0.97776456
74	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97387725
75	EGR1_19032775_ChIP-ChIP_M12_Human	0.97355784
76	CJUN_26792858_Chip-Seq_BT549_Human	0.95839452
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94337352
78	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.93267091
79	CDX2_22108803_ChIP-Seq_LS180_Human	0.92885406
80	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.92332987
81	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91705699
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90465768
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.89618834
84	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.89401855
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88670568
86	TCF4_23295773_ChIP-Seq_U87_Human	0.87751694
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87364648
88	AHR_22903824_ChIP-Seq_MCF-7_Human	0.87206312
89	JUN_21703547_ChIP-Seq_K562_Human	0.87172647
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.86684346
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.85354534
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84297063
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.80906983
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.79958739
95	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.77697346
96	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.77597774
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.77597774
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.77367470
99	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.75568961
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.75032599

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.19092531
2	MP0004145_abnormal_muscle_electrophysio	4.64362606
3	MP0003303_peritoneal_inflammation	4.30015188
4	MP0010352_gastrointestinal_tract_polyps	4.27987978
5	MP0009379_abnormal_foot_pigmentation	3.54307519
6	MP0000465_gastrointestinal_hemorrhage	3.18963065
7	MP0001666_abnormal_nutrient_absorption	2.95450515
8	MP0003868_abnormal_feces_composition	2.92030267
9	MP0000538_abnormal_urinary_bladder	2.86632647
10	MP0005248_abnormal_Harderian_gland	2.66234134
11	MP0000462_abnormal_digestive_system	2.60116469
12	MP0004885_abnormal_endolymph	2.50884824
13	MP0003045_fibrosis	2.50026624
14	MP0002234_abnormal_pharynx_morphology	2.47907276
15	MP0005645_abnormal_hypothalamus_physiol	2.45243617
16	MP0003787_abnormal_imprinting	2.42081430
17	MP0004134_abnormal_chest_morphology	2.33766642
18	MP0001664_abnormal_digestion	2.26824818
19	MP0002139_abnormal_hepatobiliary_system	2.22165268
20	MP0010155_abnormal_intestine_physiology	2.18528110
21	MP0003866_abnormal_defecation	2.17085081
22	MP0005085_abnormal_gallbladder_physiolo	2.11333788
23	MP0003646_muscle_fatigue	2.10225409
24	MP0005187_abnormal_penis_morphology	1.72408816
25	MP0004019_abnormal_vitamin_homeostasis	1.66714450
26	MP0001663_abnormal_digestive_system	1.64072484
27	MP0000490_abnormal_crypts_of	1.63061865
28	MP0004043_abnormal_pH_regulation	1.62628214
29	MP0002095_abnormal_skin_pigmentation	1.57018245
30	MP0001873_stomach_inflammation	1.51779014
31	MP0002098_abnormal_vibrissa_morphology	1.51186402
32	MP0010307_abnormal_tumor_latency	1.49955120
33	MP0002876_abnormal_thyroid_physiology	1.45481603
34	MP0001958_emphysema	1.40127737
35	MP0000013_abnormal_adipose_tissue	1.34575389
36	MP0005166_decreased_susceptibility_to	1.32348182
37	MP0003183_abnormal_peptide_metabolism	1.31314782
38	MP0005365_abnormal_bile_salt	1.31291509
39	MP0008872_abnormal_physiological_respon	1.27020936
40	MP0005381_digestive/alimentary_phenotyp	1.26995453
41	MP0004858_abnormal_nervous_system	1.26801893
42	MP0000678_abnormal_parathyroid_gland	1.24460267
43	MP0005332_abnormal_amino_acid	1.21455954
44	MP0009840_abnormal_foam_cell	1.21076595
45	MP0004142_abnormal_muscle_tone	1.16056750
46	MP0003718_maternal_effect	1.14156375
47	MP0004924_abnormal_behavior	1.14151705
48	MP0005386_behavior/neurological_phenoty	1.14151705
49	MP0002736_abnormal_nociception_after	1.13166659
50	MP0002168_other_aberrant_phenotype	1.08842081
51	MP0001501_abnormal_sleep_pattern	1.07932676
52	MP0000477_abnormal_intestine_morphology	1.02982601
53	MP0001968_abnormal_touch/_nociception	1.01353520
54	MP0004484_altered_response_of	1.00967841
55	MP0010329_abnormal_lipoprotein_level	0.99835531
56	MP0001486_abnormal_startle_reflex	0.98656640
57	MP0004147_increased_porphyrin_level	0.96597452
58	MP0008775_abnormal_heart_ventricle	0.95550687
59	MP0000049_abnormal_middle_ear	0.95239210
60	MP0003119_abnormal_digestive_system	0.92715304
61	MP0005395_other_phenotype	0.91926889
62	MP0002118_abnormal_lipid_homeostasis	0.91318726
63	MP0002396_abnormal_hematopoietic_system	0.90838873
64	MP0006292_abnormal_olfactory_placode	0.86972157
65	MP0002138_abnormal_hepatobiliary_system	0.85749549
66	MP0001485_abnormal_pinna_reflex	0.84086056
67	MP0009764_decreased_sensitivity_to	0.83017562
68	MP0005448_abnormal_energy_balance	0.81445626
69	MP0009745_abnormal_behavioral_response	0.80546913
70	MP0005387_immune_system_phenotype	0.80506487
71	MP0001790_abnormal_immune_system	0.80506487
72	MP0001502_abnormal_circadian_rhythm	0.80491685
73	MP0000569_abnormal_digit_pigmentation	0.79459420
74	MP0000427_abnormal_hair_cycle	0.79199486
75	MP0002557_abnormal_social/conspecific_i	0.78690563
76	MP0002971_abnormal_brown_adipose	0.78650697
77	MP0002249_abnormal_larynx_morphology	0.78642537
78	MP0005551_abnormal_eye_electrophysiolog	0.74796977
79	MP0005671_abnormal_response_to	0.74426912
80	MP0009115_abnormal_fat_cell	0.73818734
81	MP0000647_abnormal_sebaceous_gland	0.69328749
82	MP0000613_abnormal_salivary_gland	0.68925849
83	MP0004264_abnormal_extraembryonic_tissu	0.67334219
84	MP0008875_abnormal_xenobiotic_pharmacok	0.66823754
85	MP0004215_abnormal_myocardial_fiber	0.63599137
86	MP0001765_abnormal_ion_homeostasis	0.63564442
87	MP0002796_impaired_skin_barrier	0.63400317
88	MP0008877_abnormal_DNA_methylation	0.63303170
89	MP0003959_abnormal_lean_body	0.63071051
90	MP0001756_abnormal_urination	0.63054876
91	MP0003938_abnormal_ear_development	0.62066558
92	MP0005310_abnormal_salivary_gland	0.61674067
93	MP0002837_dystrophic_cardiac_calcinosis	0.61161229
94	MP0002896_abnormal_bone_mineralization	0.61154468
95	MP0004270_analgesia	0.60637996
96	MP0009643_abnormal_urine_homeostasis	0.59384407
97	MP0002972_abnormal_cardiac_muscle	0.59117353
98	MP0009384_cardiac_valve_regurgitation	0.58904135
99	MP0005388_respiratory_system_phenotype	0.57389428
100	MP0002133_abnormal_respiratory_system	0.57389428

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatoblastoma (HP:0002884)	6.89654270
2	Stomach cancer (HP:0012126)	6.47732529
3	Epidermoid cyst (HP:0200040)	6.30165400
4	Colon cancer (HP:0003003)	6.16406522
5	Neoplasm of the adrenal cortex (HP:0100641)	6.08314243
6	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.56368244
7	Subacute progressive viral hepatitis (HP:0006572)	5.03595366
8	Glioma (HP:0009733)	4.86152118
9	Medulloblastoma (HP:0002885)	4.70079997
10	B lymphocytopenia (HP:0010976)	4.51872784
11	Abnormality of B cell number (HP:0010975)	4.41634582
12	Malnutrition (HP:0004395)	4.26546036
13	Papillary thyroid carcinoma (HP:0002895)	3.59233001
14	Confusion (HP:0001289)	3.49843023
15	Systemic lupus erythematosus (HP:0002725)	3.49304504
16	Abnormality of the astrocytes (HP:0100707)	3.42007861
17	Astrocytoma (HP:0009592)	3.42007861
18	Neoplasm of the adrenal gland (HP:0100631)	3.40938539
19	Viral hepatitis (HP:0006562)	3.21812261
20	Diaphragmatic weakness (HP:0009113)	3.20984454
21	Widely patent fontanelles and sutures (HP:0004492)	3.13285359
22	Hyperventilation (HP:0002883)	3.05631160
23	Recurrent bronchitis (HP:0002837)	2.95239260
24	Prolonged neonatal jaundice (HP:0006579)	2.90064408
25	Renal cortical cysts (HP:0000803)	2.88923404
26	Multiple lipomas (HP:0001012)	2.86024963
27	Autoimmune hemolytic anemia (HP:0001890)	2.85573262
28	Poor eye contact (HP:0000817)	2.85127152
29	Chronic diarrhea (HP:0002028)	2.83795831
30	Focal motor seizures (HP:0011153)	2.81746509
31	Acute lymphatic leukemia (HP:0006721)	2.79193295
32	Abnormality of proline metabolism (HP:0010907)	2.77809974
33	Hydroxyprolinuria (HP:0003080)	2.77809974
34	Abnormality of urine glucose concentration (HP:0011016)	2.69184230
35	Glycosuria (HP:0003076)	2.69184230
36	Bell-shaped thorax (HP:0001591)	2.56503002
37	Hepatocellular carcinoma (HP:0001402)	2.55477387
38	Neoplasm of the small intestine (HP:0100833)	2.55096126
39	Micronodular cirrhosis (HP:0001413)	2.53335109
40	Hemiparesis (HP:0001269)	2.51887230
41	Increased number of teeth (HP:0011069)	2.50106707
42	Hemiplegia (HP:0002301)	2.47096965
43	Proximal tubulopathy (HP:0000114)	2.43863820
44	Congenital stationary night blindness (HP:0007642)	2.40487522
45	Myopathic facies (HP:0002058)	2.39628068
46	Rhabdomyosarcoma (HP:0002859)	2.37172262
47	Chest pain (HP:0100749)	2.34785243
48	Abnormality of the renal cortex (HP:0011035)	2.33872478
49	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.33399351
50	Hyperglycinuria (HP:0003108)	2.30587107
51	Neoplasm of the oral cavity (HP:0100649)	2.28825835
52	Polygenic inheritance (HP:0010982)	2.23320283
53	Abnormal social behavior (HP:0012433)	2.22478514
54	Impaired social interactions (HP:0000735)	2.22478514
55	Hypokinesia (HP:0002375)	2.21058216
56	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.19273285
57	Metabolic acidosis (HP:0001942)	2.14402956
58	Global brain atrophy (HP:0002283)	2.13013520
59	Recurrent pneumonia (HP:0006532)	2.09600170
60	Abnormality of vitamin B metabolism (HP:0004340)	2.08905272
61	Bulbar palsy (HP:0001283)	2.04530782
62	Abnormality of purine metabolism (HP:0004352)	1.95640174
63	Glomerulonephritis (HP:0000099)	1.94658424
64	Wide cranial sutures (HP:0010537)	1.91982964
65	Abnormality of glycine metabolism (HP:0010895)	1.91423922
66	Abnormality of serine family amino acid metabolism (HP:0010894)	1.91423922
67	Volvulus (HP:0002580)	1.89800825
68	Hyperuricemia (HP:0002149)	1.89759635
69	Increased purine levels (HP:0004368)	1.89759635
70	Protruding tongue (HP:0010808)	1.89338348
71	Conical tooth (HP:0000698)	1.88735068
72	Fat malabsorption (HP:0002630)	1.88290373
73	Acute hepatic failure (HP:0006554)	1.88166990
74	Nemaline bodies (HP:0003798)	1.88075693
75	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.86448839
76	Clumsiness (HP:0002312)	1.85512038
77	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.84915321
78	Hypoalbuminemia (HP:0003073)	1.83222479
79	Abnormal albumin level (HP:0012116)	1.83222479
80	Congenital sensorineural hearing impairment (HP:0008527)	1.83044390
81	Muscle fiber inclusion bodies (HP:0100299)	1.82908242
82	Abnormality of nucleobase metabolism (HP:0010932)	1.82076553
83	Uterine leiomyosarcoma (HP:0002891)	1.80448498
84	Leiomyosarcoma (HP:0100243)	1.80448498
85	Decreased circulating renin level (HP:0003351)	1.79370586
86	Nausea (HP:0002018)	1.79068981
87	Long nose (HP:0003189)	1.78005064
88	Abnormal biliary tract morphology (HP:0012440)	1.77997629
89	Nephrolithiasis (HP:0000787)	1.77366396
90	Lethargy (HP:0001254)	1.76891574
91	Retinal atrophy (HP:0001105)	1.76652036
92	Complement deficiency (HP:0004431)	1.75323411
93	Alkalosis (HP:0001948)	1.74263682
94	Thyroid carcinoma (HP:0002890)	1.73568789
95	Alopecia of scalp (HP:0002293)	1.73352251
96	Infantile muscular hypotonia (HP:0008947)	1.72684591
97	Renal tubular acidosis (HP:0001947)	1.72310941
98	Hepatitis (HP:0012115)	1.70097191
99	Abnormality of complement system (HP:0005339)	1.69062935
100	Short chin (HP:0000331)	1.68987710

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.45842474
2	CASK	4.33488489
3	NUAK1	3.85414898
4	TNIK	3.62763481
5	CSNK1G3	3.06501581
6	CSNK1A1L	2.99256656
7	STK24	2.97109133
8	CSNK1G1	2.88186303
9	EPHA2	2.79815256
10	BCR	2.76640209
11	DMPK	2.74526836
12	MUSK	2.40272173
13	OBSCN	2.39994280
14	CSNK1G2	2.37749002
15	PIK3CA	2.21083482
16	FRK	2.20359996
17	STK38L	2.13579596
18	VRK2	1.92002660
19	EPHB2	1.83228801
20	PNCK	1.79780291
21	MAP3K7	1.51818588
22	OXSR1	1.47520025
23	MAP3K12	1.32185928
24	TAF1	1.22546332
25	STK39	1.19045809
26	ADRBK2	1.15791875
27	TAOK3	1.08046135
28	MYLK	1.07983175
29	LIMK1	1.05867635
30	TXK	1.03248685
31	WNK3	1.01861897
32	NTRK3	1.01037629
33	IKBKE	1.00127867
34	STK3	0.97251144
35	MAP2K1	0.96334253
36	DYRK2	0.92901079
37	PRKAA2	0.92024194
38	MAPK13	0.90597098
39	PRKD2	0.86674211
40	BMPR1B	0.85455178
41	CSNK1A1	0.84099417
42	PTK6	0.80376473
43	ADRBK1	0.79714912
44	MAP3K11	0.76963332
45	TYK2	0.73930867
46	ILK	0.72887869
47	PINK1	0.72308347
48	PRKG2	0.71633311
49	GRK1	0.71115337
50	ERN1	0.69836877
51	GRK5	0.65129338
52	DDR2	0.64317124
53	STK16	0.64312996
54	NLK	0.62120597
55	MST4	0.59750513
56	CAMK1	0.58711992
57	PRKCI	0.57773995
58	KDR	0.57036452
59	ERBB2	0.53237359
60	TYRO3	0.51225278
61	PRKACG	0.47281475
62	PRKCA	0.46393398
63	RAF1	0.45890118
64	IKBKB	0.45420267
65	MATK	0.45281582
66	IGF1R	0.45099571
67	CHUK	0.43049829
68	MINK1	0.42686274
69	PKN1	0.41291695
70	PHKG2	0.41207100
71	PHKG1	0.41207100
72	PRKG1	0.40864723
73	PRKCQ	0.40414679
74	PRKACA	0.38907863
75	SMG1	0.36331905
76	ROCK1	0.35756745
77	HIPK2	0.35146833
78	CAMK4	0.35144522
79	PTK2B	0.32589190
80	CSNK1E	0.32265459
81	MARK1	0.31959399
82	PAK3	0.31864233
83	GRK6	0.31808700
84	VRK1	0.31251958
85	WEE1	0.29765344
86	CSNK1D	0.29263513
87	STK11	0.27040950
88	MST1R	0.26993978
89	CAMK2A	0.25328516
90	PRKCZ	0.25189942
91	CDK19	0.24203577
92	MAPK15	0.23929850
93	MAPK4	0.23818413
94	PRKAA1	0.21264865
95	MAP3K13	0.21152121
96	TBK1	0.21066658
97	MAP3K1	0.21035603
98	GRK7	0.20053104
99	SGK1	0.19991673
100	CDC42BPA	0.18745843

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.73910232
2	Fat digestion and absorption_Homo sapiens_hsa04975	4.19426249
3	Asthma_Homo sapiens_hsa05310	3.24181236
4	Sulfur relay system_Homo sapiens_hsa04122	3.23799056
5	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.13188244
6	Sulfur metabolism_Homo sapiens_hsa00920	2.42012155
7	Mineral absorption_Homo sapiens_hsa04978	2.34643775
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.32180382
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.21897463
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.16053621
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98036277
12	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.90990078
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88947978
14	Chemical carcinogenesis_Homo sapiens_hsa05204	1.83575657
15	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.83453133
16	Caffeine metabolism_Homo sapiens_hsa00232	1.81271339
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77896488
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.68353995
19	Renin-angiotensin system_Homo sapiens_hsa04614	1.67191578
20	Histidine metabolism_Homo sapiens_hsa00340	1.65842910
21	Protein digestion and absorption_Homo sapiens_hsa04974	1.58909732
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.56066278
23	Allograft rejection_Homo sapiens_hsa05330	1.52098751
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51313200
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.50827930
26	Fatty acid degradation_Homo sapiens_hsa00071	1.46495847
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.43401824
28	Pancreatic secretion_Homo sapiens_hsa04972	1.42606443
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.41701015
30	Glutathione metabolism_Homo sapiens_hsa00480	1.40542014
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.36425166
32	Arginine and proline metabolism_Homo sapiens_hsa00330	1.34549445
33	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.33619061
34	Bile secretion_Homo sapiens_hsa04976	1.33094656
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32274364
36	Peroxisome_Homo sapiens_hsa04146	1.30915427
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18713388
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14175260
39	Retinol metabolism_Homo sapiens_hsa00830	1.13660507
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.12617000
41	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.12057494
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11030399
43	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.09505831
44	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08214485
45	Fatty acid elongation_Homo sapiens_hsa00062	1.03429949
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01807022
47	Folate biosynthesis_Homo sapiens_hsa00790	1.00122097
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96888553
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80501483
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.78029400
51	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.77680645
52	Insulin secretion_Homo sapiens_hsa04911	0.75959952
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72531071
54	Regulation of autophagy_Homo sapiens_hsa04140	0.71789801
55	Salivary secretion_Homo sapiens_hsa04970	0.70893327
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70666074
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70508377
58	Gastric acid secretion_Homo sapiens_hsa04971	0.68292230
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65663943
60	Butanoate metabolism_Homo sapiens_hsa00650	0.64586581
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.64212042
62	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.61315309
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60287748
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56727163
65	Viral myocarditis_Homo sapiens_hsa05416	0.55768977
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.55576690
67	Propanoate metabolism_Homo sapiens_hsa00640	0.53686222
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.52785713
69	Renin secretion_Homo sapiens_hsa04924	0.52673413
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49675905
71	Chemokine signaling pathway_Homo sapiens_hsa04062	0.49609827
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46926132
73	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.46840617
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40990385
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.38577377
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.37905897
77	Oxidative phosphorylation_Homo sapiens_hsa00190	0.35850280
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35274165
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34859696
80	African trypanosomiasis_Homo sapiens_hsa05143	0.33311923
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32954697
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32824836
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32650726
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.29722332
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29606881
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28913429
87	Olfactory transduction_Homo sapiens_hsa04740	0.26366510
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26260488
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24711218
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20825406
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.20824862
92	Alzheimers disease_Homo sapiens_hsa05010	0.18722311
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.18685003
94	ABC transporters_Homo sapiens_hsa02010	0.17751007
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17498481
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17230106
97	Primary immunodeficiency_Homo sapiens_hsa05340	0.17120560
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.15845836
99	Metabolic pathways_Homo sapiens_hsa01100	0.14937708
100	Pertussis_Homo sapiens_hsa05133	0.14469041

RPL9P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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