ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.24424292
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.61204883
3	ATP synthesis coupled proton transport (GO:0015986)	5.61204883
4	behavioral response to nicotine (GO:0035095)	5.55656962
5	maturation of SSU-rRNA (GO:0030490)	5.47706945
6	viral transcription (GO:0019083)	5.36547649
7	translational termination (GO:0006415)	5.19216985
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.99453391
9	protein neddylation (GO:0045116)	4.73520302
10	chaperone-mediated protein transport (GO:0072321)	4.56385102
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.55511882
12	cotranslational protein targeting to membrane (GO:0006613)	4.50720368
13	protein targeting to ER (GO:0045047)	4.48867499
14	translational elongation (GO:0006414)	4.47762947
15	ribosomal large subunit biogenesis (GO:0042273)	4.30576788
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.30472049
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.29077019
18	protein localization to endoplasmic reticulum (GO:0070972)	4.25435842
19	ribosomal small subunit biogenesis (GO:0042274)	4.24957863
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17410276
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09034833
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09034833
23	NADH dehydrogenase complex assembly (GO:0010257)	4.09034833
24	protein complex biogenesis (GO:0070271)	4.08739724
25	DNA deamination (GO:0045006)	3.98360238
26	viral life cycle (GO:0019058)	3.93668485
27	preassembly of GPI anchor in ER membrane (GO:0016254)	3.91800704
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.91677054
29	electron transport chain (GO:0022900)	3.85467293
30	respiratory electron transport chain (GO:0022904)	3.83393553
31	cellular protein complex disassembly (GO:0043624)	3.80403715
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.69010998
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60244339
34	translational initiation (GO:0006413)	3.56038355
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.38750847
36	translation (GO:0006412)	3.38206648
37	piRNA metabolic process (GO:0034587)	3.37972469
38	GTP biosynthetic process (GO:0006183)	3.36607654
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.32721906
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.32721906
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27691814
42	somite development (GO:0061053)	3.24021172
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.23941235
44	hydrogen ion transmembrane transport (GO:1902600)	3.20540002
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20424199
46	ATP biosynthetic process (GO:0006754)	3.19941313
47	protein complex disassembly (GO:0043241)	3.11589644
48	mannosylation (GO:0097502)	3.10308671
49	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.02296201
50	proton transport (GO:0015992)	3.00246802
51	macromolecular complex disassembly (GO:0032984)	3.00032506
52	positive regulation of prostaglandin secretion (GO:0032308)	2.99880568
53	GPI anchor metabolic process (GO:0006505)	2.97608476
54	hydrogen transport (GO:0006818)	2.95964370
55	cellular component biogenesis (GO:0044085)	2.94395799
56	protein targeting to membrane (GO:0006612)	2.92242548
57	behavioral response to ethanol (GO:0048149)	2.88187244
58	fucose catabolic process (GO:0019317)	2.87425390
59	L-fucose metabolic process (GO:0042354)	2.87425390
60	L-fucose catabolic process (GO:0042355)	2.87425390
61	synaptic transmission, cholinergic (GO:0007271)	2.82573797
62	neurofilament cytoskeleton organization (GO:0060052)	2.81531473
63	cellular response to ATP (GO:0071318)	2.79287781
64	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.77269793
65	DNA methylation involved in gamete generation (GO:0043046)	2.72213295
66	positive regulation of fatty acid transport (GO:2000193)	2.71259660
67	UTP metabolic process (GO:0046051)	2.70507667
68	negative regulation of telomere maintenance (GO:0032205)	2.67643409
69	UTP biosynthetic process (GO:0006228)	2.67584138
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.66439838
71	cell proliferation in forebrain (GO:0021846)	2.65723784
72	tRNA processing (GO:0008033)	2.65124759
73	ribonucleoprotein complex biogenesis (GO:0022613)	2.62460435
74	epithelial cilium movement (GO:0003351)	2.61826767
75	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.61358604
76	substrate-independent telencephalic tangential migration (GO:0021826)	2.61358604
77	negative regulation of response to food (GO:0032096)	2.61078578
78	negative regulation of appetite (GO:0032099)	2.61078578
79	positive regulation of respiratory burst (GO:0060267)	2.60460676
80	mRNA catabolic process (GO:0006402)	2.58989619
81	GPI anchor biosynthetic process (GO:0006506)	2.58269768
82	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.57407097
83	response to pheromone (GO:0019236)	2.56761387
84	intracellular protein transmembrane import (GO:0044743)	2.56333396
85	parturition (GO:0007567)	2.53206960
86	C-terminal protein lipidation (GO:0006501)	2.52634229
87	aldehyde catabolic process (GO:0046185)	2.52489667
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52084186
89	rRNA processing (GO:0006364)	2.51289713
90	protein-cofactor linkage (GO:0018065)	2.50189605
91	rRNA metabolic process (GO:0016072)	2.49843546
92	auditory receptor cell differentiation (GO:0042491)	2.48148460
93	regulation of isotype switching to IgG isotypes (GO:0048302)	2.47952092
94	positive regulation of icosanoid secretion (GO:0032305)	2.47702013
95	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.47522947
96	protein polyglutamylation (GO:0018095)	2.47465383
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.47318200
98	peptidyl-histidine modification (GO:0018202)	2.46322638
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.45783006
100	termination of RNA polymerase III transcription (GO:0006386)	2.45783006

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.07193271
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60368362
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23335594
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.93150275
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87144253
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84921637
7	VDR_22108803_ChIP-Seq_LS180_Human	2.79521881
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75634827
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.72703142
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12886777
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.04763140
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99482484
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.90221375
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89363147
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86533557
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.81844930
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.81651466
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.80867276
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77514136
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.73953001
21	EWS_26573619_Chip-Seq_HEK293_Human	1.73952652
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70864603
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.68087723
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.64680070
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62573670
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59599127
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56530784
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51783412
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51614789
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50838871
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.50787884
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48154352
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47824839
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43452545
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42834834
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42712299
37	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.40687340
38	FUS_26573619_Chip-Seq_HEK293_Human	1.39089813
39	P300_19829295_ChIP-Seq_ESCs_Human	1.38822363
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37534834
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.37434819
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35778307
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33053145
44	NCOR_22424771_ChIP-Seq_293T_Human	1.32831902
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29060100
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28597503
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.28274534
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27848116
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27848116
50	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26850397
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.26651199
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26132910
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.25675343
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25675343
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24983696
56	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24624369
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23854369
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.22990786
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21646821
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21646821
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19936689
62	AR_20517297_ChIP-Seq_VCAP_Human	1.18423262
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17061500
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16764335
65	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16483530
66	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.15872849
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14994292
68	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.11830818
69	ERA_21632823_ChIP-Seq_H3396_Human	1.11602439
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11427861
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08838533
72	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07266193
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07247639
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06674731
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05883962
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.04783115
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04021627
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02769776
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.02688157
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.02484989
81	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02366212
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98266994
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98156555
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98013238
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96599568
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95950511
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95646123
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95562420
89	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95168075
90	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.94878587
91	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94116177
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93571028
93	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92765808
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92645862
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92384041
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.92366617
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91176758
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90908467
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.90897860
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.88809358

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.04663446
2	MP0006292_abnormal_olfactory_placode	3.68428853
3	MP0003787_abnormal_imprinting	3.33656999
4	MP0008877_abnormal_DNA_methylation	3.24719514
5	MP0004142_abnormal_muscle_tone	2.35349109
6	MP0002102_abnormal_ear_morphology	2.32172951
7	MP0006072_abnormal_retinal_apoptosis	2.15503800
8	MP0004885_abnormal_endolymph	2.09878973
9	MP0003646_muscle_fatigue	2.05417179
10	MP0008872_abnormal_physiological_respon	2.00838366
11	MP0001968_abnormal_touch/_nociception	1.93266652
12	MP0005551_abnormal_eye_electrophysiolog	1.90788955
13	MP0006276_abnormal_autonomic_nervous	1.87641927
14	MP0002138_abnormal_hepatobiliary_system	1.86279154
15	MP0005646_abnormal_pituitary_gland	1.84893143
16	MP0003122_maternal_imprinting	1.79850295
17	MP0002272_abnormal_nervous_system	1.75021443
18	MP0003121_genomic_imprinting	1.69760331
19	MP0008875_abnormal_xenobiotic_pharmacok	1.68457175
20	MP0005645_abnormal_hypothalamus_physiol	1.67449240
21	MP0002736_abnormal_nociception_after	1.63886948
22	MP0001835_abnormal_antigen_presentation	1.61871213
23	MP0002837_dystrophic_cardiac_calcinosis	1.55289318
24	MP0001970_abnormal_pain_threshold	1.46635212
25	MP0008789_abnormal_olfactory_epithelium	1.45696619
26	MP0005423_abnormal_somatic_nervous	1.44178132
27	MP0002163_abnormal_gland_morphology	1.41860141
28	MP0003123_paternal_imprinting	1.41052618
29	MP0002653_abnormal_ependyma_morphology	1.39837703
30	MP0000372_irregular_coat_pigmentation	1.39831723
31	MP0001873_stomach_inflammation	1.39475035
32	MP0001485_abnormal_pinna_reflex	1.38484652
33	MP0002638_abnormal_pupillary_reflex	1.37801670
34	MP0001905_abnormal_dopamine_level	1.37795657
35	MP0001440_abnormal_grooming_behavior	1.35022159
36	MP0005084_abnormal_gallbladder_morpholo	1.35009968
37	MP0002160_abnormal_reproductive_system	1.33749610
38	MP0009745_abnormal_behavioral_response	1.33633991
39	MP0002938_white_spotting	1.32430232
40	MP0002733_abnormal_thermal_nociception	1.31834413
41	MP0004147_increased_porphyrin_level	1.31809460
42	MP0000631_abnormal_neuroendocrine_gland	1.31702150
43	MP0001986_abnormal_taste_sensitivity	1.31100674
44	MP0004742_abnormal_vestibular_system	1.30922080
45	MP0005389_reproductive_system_phenotype	1.30682911
46	MP0002876_abnormal_thyroid_physiology	1.30389738
47	MP0003880_abnormal_central_pattern	1.29441605
48	MP0005253_abnormal_eye_physiology	1.27078400
49	MP0002735_abnormal_chemical_nociception	1.25230252
50	MP0004145_abnormal_muscle_electrophysio	1.24468380
51	MP0001984_abnormal_olfaction	1.23133618
52	MP0002184_abnormal_innervation	1.22874824
53	MP0001529_abnormal_vocalization	1.22672854
54	MP0005671_abnormal_response_to	1.22632570
55	MP0002557_abnormal_social/conspecific_i	1.21000263
56	MP0002572_abnormal_emotion/affect_behav	1.19348810
57	MP0001486_abnormal_startle_reflex	1.17805711
58	MP0003718_maternal_effect	1.17289820
59	MP0000778_abnormal_nervous_system	1.16472192
60	MP0001919_abnormal_reproductive_system	1.15475591
61	MP0000049_abnormal_middle_ear	1.13359919
62	MP0005085_abnormal_gallbladder_physiolo	1.12907391
63	MP0009046_muscle_twitch	1.11123972
64	MP0003878_abnormal_ear_physiology	1.10655873
65	MP0005377_hearing/vestibular/ear_phenot	1.10655873
66	MP0009764_decreased_sensitivity_to	1.07978452
67	MP0008995_early_reproductive_senescence	1.07944217
68	MP0001293_anophthalmia	1.07605965
69	MP0002234_abnormal_pharynx_morphology	1.07463193
70	MP0005499_abnormal_olfactory_system	1.05331208
71	MP0005394_taste/olfaction_phenotype	1.05331208
72	MP0000230_abnormal_systemic_arterial	1.03925648
73	MP0002752_abnormal_somatic_nervous	1.02060917
74	MP0003011_delayed_dark_adaptation	1.01544218
75	MP0005379_endocrine/exocrine_gland_phen	0.98242388
76	MP0000026_abnormal_inner_ear	0.96591683
77	MP0001663_abnormal_digestive_system	0.96151554
78	MP0003635_abnormal_synaptic_transmissio	0.95772623
79	MP0005195_abnormal_posterior_eye	0.94357897
80	MP0002734_abnormal_mechanical_nocicepti	0.94215532
81	MP0000955_abnormal_spinal_cord	0.93547147
82	MP0001963_abnormal_hearing_physiology	0.92689422
83	MP0008775_abnormal_heart_ventricle	0.90683878
84	MP0001348_abnormal_lacrimal_gland	0.89589646
85	MP0002063_abnormal_learning/memory/cond	0.89089951
86	MP0006036_abnormal_mitochondrial_physio	0.88421345
87	MP0003567_abnormal_fetal_cardiomyocyte	0.87802822
88	MP0000685_abnormal_immune_system	0.85809353
89	MP0003315_abnormal_perineum_morphology	0.83088182
90	MP0003186_abnormal_redox_activity	0.82005614
91	MP0002064_seizures	0.81617316
92	MP0004924_abnormal_behavior	0.81561007
93	MP0005386_behavior/neurological_phenoty	0.81561007
94	MP0003195_calcinosis	0.81206649
95	MP0001800_abnormal_humoral_immune	0.81063662
96	MP0002067_abnormal_sensory_capabilities	0.80436666
97	MP0002229_neurodegeneration	0.80389379
98	MP0002210_abnormal_sex_determination	0.78064555
99	MP0004133_heterotaxia	0.77665521
100	MP0005332_abnormal_amino_acid	0.76860124

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.73543434
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.17135310
3	Acute encephalopathy (HP:0006846)	4.15262892
4	Reticulocytopenia (HP:0001896)	4.08926674
5	Progressive macrocephaly (HP:0004481)	3.90819224
6	Mitochondrial inheritance (HP:0001427)	3.87459368
7	Abnormality of midbrain morphology (HP:0002418)	3.62083950
8	Molar tooth sign on MRI (HP:0002419)	3.62083950
9	Increased CSF lactate (HP:0002490)	3.55607461
10	Pancreatic cysts (HP:0001737)	3.37971516
11	3-Methylglutaconic aciduria (HP:0003535)	3.35532795
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.17283447
13	Hepatocellular necrosis (HP:0001404)	3.16024256
14	Congenital stationary night blindness (HP:0007642)	3.04722248
15	Cerebral edema (HP:0002181)	2.97593574
16	Pancreatic fibrosis (HP:0100732)	2.94359015
17	Hepatic necrosis (HP:0002605)	2.88601634
18	Optic disc pallor (HP:0000543)	2.88112160
19	Type II lissencephaly (HP:0007260)	2.87261479
20	Renal Fanconi syndrome (HP:0001994)	2.86750165
21	Nephronophthisis (HP:0000090)	2.81166220
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.78512246
23	Increased hepatocellular lipid droplets (HP:0006565)	2.72474150
24	Macrocytic anemia (HP:0001972)	2.72146731
25	Lipid accumulation in hepatocytes (HP:0006561)	2.61662577
26	Abnormal drinking behavior (HP:0030082)	2.56732648
27	Polydipsia (HP:0001959)	2.56732648
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.56581613
29	Medial flaring of the eyebrow (HP:0010747)	2.51063312
30	Adrenal hypoplasia (HP:0000835)	2.50702268
31	True hermaphroditism (HP:0010459)	2.46504406
32	Pendular nystagmus (HP:0012043)	2.46287929
33	Methylmalonic aciduria (HP:0012120)	2.45751413
34	Abolished electroretinogram (ERG) (HP:0000550)	2.45219941
35	Septo-optic dysplasia (HP:0100842)	2.45118809
36	Abnormal number of erythroid precursors (HP:0012131)	2.42700455
37	Increased serum lactate (HP:0002151)	2.41835869
38	Methylmalonic acidemia (HP:0002912)	2.38228475
39	Abnormality of the renal cortex (HP:0011035)	2.37487814
40	Absent thumb (HP:0009777)	2.34460900
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.33448635
42	Abnormality of the renal medulla (HP:0100957)	2.32849631
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30613006
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30613006
45	Asplenia (HP:0001746)	2.28030395
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27567978
47	Abnormality of alanine metabolism (HP:0010916)	2.27567978
48	Hyperalaninemia (HP:0003348)	2.27567978
49	Leukodystrophy (HP:0002415)	2.27494576
50	Lactic acidosis (HP:0003128)	2.25481703
51	Abnormality of renal resorption (HP:0011038)	2.16853574
52	Polyuria (HP:0000103)	2.16503145
53	Elevated erythrocyte sedimentation rate (HP:0003565)	2.16392080
54	Failure to thrive in infancy (HP:0001531)	2.15977792
55	Lethargy (HP:0001254)	2.15575002
56	Congenital, generalized hypertrichosis (HP:0004540)	2.15245000
57	Abnormality of urine glucose concentration (HP:0011016)	2.14238335
58	Glycosuria (HP:0003076)	2.14238335
59	Agitation (HP:0000713)	2.13471569
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11444058
61	Pallor (HP:0000980)	2.10348680
62	Abnormal biliary tract physiology (HP:0012439)	2.09398438
63	Bile duct proliferation (HP:0001408)	2.09398438
64	Hyperglycinemia (HP:0002154)	2.08662506
65	Stomatitis (HP:0010280)	2.07034389
66	Respiratory failure (HP:0002878)	2.03911605
67	Tubular atrophy (HP:0000092)	2.03853368
68	Increased intramyocellular lipid droplets (HP:0012240)	2.03022735
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.99175809
70	Myokymia (HP:0002411)	1.98828259
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98072851
72	Absent/shortened dynein arms (HP:0200106)	1.98072851
73	Cystic liver disease (HP:0006706)	1.97607810
74	Optic nerve hypoplasia (HP:0000609)	1.96793353
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94997763
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.92745424
77	Decreased central vision (HP:0007663)	1.92464261
78	Abnormality of DNA repair (HP:0003254)	1.91762549
79	Generalized aminoaciduria (HP:0002909)	1.91690889
80	Exertional dyspnea (HP:0002875)	1.89847026
81	Chronic hepatic failure (HP:0100626)	1.89433079
82	Type 2 muscle fiber atrophy (HP:0003554)	1.87999947
83	Gait imbalance (HP:0002141)	1.84239381
84	Sclerocornea (HP:0000647)	1.83967867
85	Rib fusion (HP:0000902)	1.83315447
86	IgG deficiency (HP:0004315)	1.83240623
87	Abnormality of the pons (HP:0007361)	1.82454175
88	Hypoplasia of the pons (HP:0012110)	1.80963241
89	Exercise intolerance (HP:0003546)	1.78568035
90	Growth hormone deficiency (HP:0000824)	1.78214683
91	Renal cortical cysts (HP:0000803)	1.78143992
92	Abnormality of the labia minora (HP:0012880)	1.78096142
93	Pachygyria (HP:0001302)	1.77383290
94	Abnormal urine output (HP:0012590)	1.76830038
95	Hypoplasia of the ulna (HP:0003022)	1.75949136
96	Colon cancer (HP:0003003)	1.75405335
97	Inability to walk (HP:0002540)	1.72205120
98	Abnormality of B cell number (HP:0010975)	1.71170034
99	Congenital primary aphakia (HP:0007707)	1.70640259
100	Increased muscle lipid content (HP:0009058)	1.69663958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.17419474
2	WNK4	2.98705479
3	ADRBK2	2.79899604
4	TAOK3	2.70064423
5	GRK1	2.56181821
6	PINK1	2.48566683
7	FRK	2.47583474
8	BMPR1B	2.43204995
9	TXK	2.36330106
10	NUAK1	2.25254767
11	ZAK	2.24476350
12	STK16	2.15240405
13	TLK1	2.13550779
14	DYRK2	2.08674567
15	WNK3	2.04686488
16	CDK19	2.01170331
17	TIE1	2.00999163
18	BCKDK	1.86630754
19	VRK2	1.76785448
20	TRIM28	1.70654212
21	NME1	1.66298361
22	CASK	1.50564720
23	STK39	1.41653154
24	OXSR1	1.26363073
25	FLT3	1.22596133
26	KIT	1.16977543
27	MINK1	1.16571931
28	MAP3K4	1.16525342
29	MAP2K7	1.11200290
30	MAPK13	1.08562819
31	MAP3K12	1.05905924
32	PHKG2	0.99652935
33	PHKG1	0.99652935
34	VRK1	0.97315874
35	TEC	0.96139636
36	INSRR	0.91701680
37	MAP4K1	0.91597586
38	PRKCG	0.91303155
39	CSNK1G3	0.89335371
40	CSNK1G2	0.87126485
41	MARK1	0.86211027
42	IKBKB	0.84019593
43	PDK2	0.82935019
44	ADRBK1	0.80764665
45	EIF2AK3	0.80750523
46	GRK5	0.78578188
47	IKBKE	0.77175018
48	PIK3CA	0.76747295
49	ITK	0.75943196
50	CSNK1G1	0.73925250
51	MST4	0.73765615
52	PRKCQ	0.72695433
53	MAP2K6	0.71975018
54	MUSK	0.71807746
55	EPHB2	0.66362315
56	PRKACA	0.66208845
57	CSNK1A1L	0.65409401
58	EIF2AK2	0.63872943
59	PASK	0.63655185
60	GRK7	0.63652866
61	SCYL2	0.63029075
62	CAMK1	0.62327678
63	SYK	0.61458384
64	PAK3	0.60529667
65	ERBB3	0.60415181
66	CSNK2A2	0.60171754
67	NEK1	0.59957051
68	CAMKK2	0.59446526
69	CAMK2A	0.57706884
70	PLK3	0.56438551
71	TAF1	0.55973276
72	WNK1	0.55881241
73	DAPK3	0.54841325
74	CSNK1A1	0.54693221
75	LRRK2	0.54443702
76	GRK6	0.53840416
77	RPS6KA5	0.52195893
78	STK11	0.51739709
79	PRKCA	0.49869175
80	PLK2	0.49701753
81	CSNK1E	0.49066960
82	PRKCE	0.48724547
83	OBSCN	0.47900643
84	ACVR1B	0.46188458
85	CSF1R	0.45881984
86	CAMK2D	0.45852098
87	MKNK2	0.45816154
88	MYLK	0.45268849
89	CSNK2A1	0.45236794
90	MAP3K11	0.43984415
91	NTRK2	0.43186423
92	DAPK2	0.42770645
93	BMPR2	0.42616480
94	PLK4	0.42534506
95	TNIK	0.42352989
96	TSSK6	0.41552875
97	PIM1	0.40751565
98	PRKCI	0.40332384
99	TYRO3	0.39833932
100	TGFBR1	0.38693982

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.44471481
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.89615674
3	Asthma_Homo sapiens_hsa05310	3.40882021
4	Parkinsons disease_Homo sapiens_hsa05012	3.09612780
5	Proteasome_Homo sapiens_hsa03050	2.69348572
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.68494507
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.42758218
8	Allograft rejection_Homo sapiens_hsa05330	2.32947037
9	Protein export_Homo sapiens_hsa03060	2.19846617
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.19406171
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.15176350
12	Alzheimers disease_Homo sapiens_hsa05010	2.14908425
13	Huntingtons disease_Homo sapiens_hsa05016	2.07270565
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.93433974
15	RNA polymerase_Homo sapiens_hsa03020	1.92403878
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90277769
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.83562379
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83522186
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.66129839
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62580944
21	Phototransduction_Homo sapiens_hsa04744	1.50531506
22	RNA degradation_Homo sapiens_hsa03018	1.49250599
23	Basal transcription factors_Homo sapiens_hsa03022	1.44940281
24	Homologous recombination_Homo sapiens_hsa03440	1.38876376
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34141007
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29569901
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27038477
28	Propanoate metabolism_Homo sapiens_hsa00640	1.26873286
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25998176
30	Nicotine addiction_Homo sapiens_hsa05033	1.24758793
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23085042
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.19003846
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12484465
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.03639218
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.02278270
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.01247280
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.00861853
38	Peroxisome_Homo sapiens_hsa04146	1.00630627
39	Butanoate metabolism_Homo sapiens_hsa00650	1.00307292
40	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99732245
41	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99076885
42	One carbon pool by folate_Homo sapiens_hsa00670	0.99008536
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94048485
44	Olfactory transduction_Homo sapiens_hsa04740	0.93561925
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91955605
46	Caffeine metabolism_Homo sapiens_hsa00232	0.89616266
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88765159
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.87040179
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.86507719
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85530968
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84407820
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83463274
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79938245
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79477948
55	Regulation of autophagy_Homo sapiens_hsa04140	0.77434023
56	Purine metabolism_Homo sapiens_hsa00230	0.75978045
57	RNA transport_Homo sapiens_hsa03013	0.71863360
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71297231
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71113244
60	Metabolic pathways_Homo sapiens_hsa01100	0.68205066
61	Retinol metabolism_Homo sapiens_hsa00830	0.66388317
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.66366705
63	Mismatch repair_Homo sapiens_hsa03430	0.64188265
64	Sulfur metabolism_Homo sapiens_hsa00920	0.63877970
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62996929
66	Morphine addiction_Homo sapiens_hsa05032	0.62978213
67	Taste transduction_Homo sapiens_hsa04742	0.62651721
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61078401
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60102673
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59313593
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58981800
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57141332
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56995874
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.55486263
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55037369
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53068048
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51219250
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51111674
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48199867
80	Salivary secretion_Homo sapiens_hsa04970	0.48106641
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47666575
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45879791
83	Spliceosome_Homo sapiens_hsa03040	0.44798905
84	Insulin secretion_Homo sapiens_hsa04911	0.44763741
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43636015
86	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41261576
87	Sulfur relay system_Homo sapiens_hsa04122	0.40553110
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40345197
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39725623
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39562991
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.39425730
92	Fatty acid degradation_Homo sapiens_hsa00071	0.38830627
93	Viral myocarditis_Homo sapiens_hsa05416	0.38171822
94	GABAergic synapse_Homo sapiens_hsa04727	0.35332722
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33749087
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31833642
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31522169
98	Base excision repair_Homo sapiens_hsa03410	0.30695020
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30351558
100	Serotonergic synapse_Homo sapiens_hsa04726	0.29659463

RPL9P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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