ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.04374748
2	ATP synthesis coupled proton transport (GO:0015986)	5.00001069
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.00001069
4	viral transcription (GO:0019083)	4.53742079
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.35910132
6	translational termination (GO:0006415)	4.35509698
7	protein neddylation (GO:0045116)	4.33758163
8	maturation of SSU-rRNA (GO:0030490)	4.29584980
9	behavioral response to nicotine (GO:0035095)	4.17062696
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.14911549
11	aggressive behavior (GO:0002118)	4.03384990
12	DNA deamination (GO:0045006)	4.03113431
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.91436440
14	tachykinin receptor signaling pathway (GO:0007217)	3.89361360
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.88429618
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.88429618
17	cotranslational protein targeting to membrane (GO:0006613)	3.85291133
18	protein targeting to ER (GO:0045047)	3.81798922
19	positive regulation of action potential (GO:0045760)	3.81234142
20	chaperone-mediated protein transport (GO:0072321)	3.79474242
21	electron transport chain (GO:0022900)	3.78740395
22	preassembly of GPI anchor in ER membrane (GO:0016254)	3.77968795
23	respiratory electron transport chain (GO:0022904)	3.76431184
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.72478922
25	translational elongation (GO:0006414)	3.72475884
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.66958276
27	protein localization to endoplasmic reticulum (GO:0070972)	3.63724782
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.54191623
29	GTP biosynthetic process (GO:0006183)	3.50118033
30	protein complex biogenesis (GO:0070271)	3.43847498
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41783157
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41783157
33	NADH dehydrogenase complex assembly (GO:0010257)	3.41783157
34	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.31254016
35	mannosylation (GO:0097502)	3.31083499
36	regulation of action potential (GO:0098900)	3.29781480
37	negative regulation of telomere maintenance (GO:0032205)	3.27067882
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22322983
39	drinking behavior (GO:0042756)	3.19769295
40	viral life cycle (GO:0019058)	3.18855943
41	cellular protein complex disassembly (GO:0043624)	3.13210591
42	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13158870
43	ribosomal small subunit biogenesis (GO:0042274)	3.11893949
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09184628
45	maturation of 5.8S rRNA (GO:0000460)	3.08072455
46	L-fucose catabolic process (GO:0042355)	3.05289286
47	fucose catabolic process (GO:0019317)	3.05289286
48	L-fucose metabolic process (GO:0042354)	3.05289286
49	ribosomal large subunit biogenesis (GO:0042273)	3.04778466
50	mitochondrial respiratory chain complex assembly (GO:0033108)	3.02717453
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99947671
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99182564
53	kynurenine metabolic process (GO:0070189)	2.98766252
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.98235953
55	UTP metabolic process (GO:0046051)	2.97662564
56	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.96960295
57	regulation of cilium movement (GO:0003352)	2.96626816
58	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.94631581
59	UTP biosynthetic process (GO:0006228)	2.94156792
60	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.91239289
61	translational initiation (GO:0006413)	2.89155206
62	rRNA catabolic process (GO:0016075)	2.88922280
63	proton transport (GO:0015992)	2.87037679
64	hydrogen transport (GO:0006818)	2.83134374
65	protein-cofactor linkage (GO:0018065)	2.82531534
66	ATP biosynthetic process (GO:0006754)	2.81852139
67	hydrogen ion transmembrane transport (GO:1902600)	2.80248823
68	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.77671555
69	protein polyglutamylation (GO:0018095)	2.77548935
70	resolution of meiotic recombination intermediates (GO:0000712)	2.75305149
71	positive regulation of prostaglandin secretion (GO:0032308)	2.73446066
72	translation (GO:0006412)	2.72678941
73	ubiquinone biosynthetic process (GO:0006744)	2.71996372
74	adaptation of signaling pathway (GO:0023058)	2.70798403
75	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.68357377
76	base-excision repair, AP site formation (GO:0006285)	2.68133038
77	axoneme assembly (GO:0035082)	2.67659621
78	piRNA metabolic process (GO:0034587)	2.66041508
79	gonadal mesoderm development (GO:0007506)	2.64426246
80	positive regulation of digestive system process (GO:0060456)	2.64180784
81	ncRNA catabolic process (GO:0034661)	2.63655115
82	tryptophan catabolic process (GO:0006569)	2.62540857
83	indole-containing compound catabolic process (GO:0042436)	2.62540857
84	indolalkylamine catabolic process (GO:0046218)	2.62540857
85	amine catabolic process (GO:0009310)	2.59677537
86	cellular biogenic amine catabolic process (GO:0042402)	2.59677537
87	cellular ketone body metabolic process (GO:0046950)	2.59220277
88	C-terminal protein lipidation (GO:0006501)	2.59118937
89	GPI anchor metabolic process (GO:0006505)	2.58599971
90	epithelial cilium movement (GO:0003351)	2.57300604
91	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.56522635
92	cellular component biogenesis (GO:0044085)	2.56397998
93	tryptophan metabolic process (GO:0006568)	2.56001872
94	tRNA processing (GO:0008033)	2.55868671
95	regulation of microtubule-based movement (GO:0060632)	2.55859914
96	cellular response to ATP (GO:0071318)	2.55009583
97	positive regulation of mitochondrial fission (GO:0090141)	2.54926161
98	respiratory chain complex IV assembly (GO:0008535)	2.54588392
99	spliceosomal complex assembly (GO:0000245)	2.54284855
100	protein complex disassembly (GO:0043241)	2.53411837

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.76559674
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.59279613
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54475590
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.91268684
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76417910
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73412675
7	VDR_22108803_ChIP-Seq_LS180_Human	2.65941472
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.55174591
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26933284
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23625162
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18206641
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.03443560
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.91205992
14	VDR_23849224_ChIP-Seq_CD4+_Human	1.90511707
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.89133015
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.87488044
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86002485
18	EWS_26573619_Chip-Seq_HEK293_Human	1.80007162
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76740474
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75784340
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.75203438
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74476149
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72378389
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70944463
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.70378551
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68973735
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62920676
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62634484
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.60272140
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.58538583
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.58034424
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56971484
33	FUS_26573619_Chip-Seq_HEK293_Human	1.56773564
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53029739
35	P300_19829295_ChIP-Seq_ESCs_Human	1.50959982
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39560394
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38978289
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38978289
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38239947
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35359071
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35179234
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.35035309
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34069217
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34069217
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31891360
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29623345
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28673938
48	AR_20517297_ChIP-Seq_VCAP_Human	1.28171462
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.27974561
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27974561
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26224614
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21829077
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21066804
54	NCOR_22424771_ChIP-Seq_293T_Human	1.20810112
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20732801
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20591679
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20402704
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20342110
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19110613
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17772794
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17364953
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.16986920
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16492031
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.16412425
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15814208
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15489437
67	STAT1_20625510_ChIP-Seq_HELA_Human	1.14854998
68	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13854335
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11637720
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10479837
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.09129623
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08465501
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08221560
74	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07841593
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05847400
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.05807872
77	ERA_21632823_ChIP-Seq_H3396_Human	1.04716634
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02819513
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.02804462
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02456515
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01625199
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00961009
83	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.00069971
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99940849
85	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.99527080
86	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99283795
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98495513
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98234823
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98118495
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.98107835
91	GATA3_26560356_Chip-Seq_TH2_Human	0.97392498
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97178137
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95330958
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95326391
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.95286522
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94834736
97	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90213558
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90207243
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.89135226
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88835037

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.44393850
2	MP0001968_abnormal_touch/_nociception	3.34526565
3	MP0002736_abnormal_nociception_after	3.19210594
4	MP0003787_abnormal_imprinting	3.16380839
5	MP0008872_abnormal_physiological_respon	2.63376396
6	MP0009379_abnormal_foot_pigmentation	2.63357410
7	MP0004142_abnormal_muscle_tone	2.62896562
8	MP0002837_dystrophic_cardiac_calcinosis	2.61498959
9	MP0003646_muscle_fatigue	2.45705554
10	MP0006292_abnormal_olfactory_placode	2.38604130
11	MP0008875_abnormal_xenobiotic_pharmacok	2.27125921
12	MP0001529_abnormal_vocalization	2.17614695
13	MP0004885_abnormal_endolymph	2.04312689
14	MP0002735_abnormal_chemical_nociception	2.02547063
15	MP0006072_abnormal_retinal_apoptosis	1.93013093
16	MP0002102_abnormal_ear_morphology	1.86853453
17	MP0003121_genomic_imprinting	1.78860950
18	MP0005551_abnormal_eye_electrophysiolog	1.72528675
19	MP0003011_delayed_dark_adaptation	1.72130755
20	MP0008995_early_reproductive_senescence	1.71098646
21	MP0005645_abnormal_hypothalamus_physiol	1.68436303
22	MP0002272_abnormal_nervous_system	1.64344842
23	MP0003122_maternal_imprinting	1.63444115
24	MP0002277_abnormal_respiratory_mucosa	1.57437043
25	MP0009764_decreased_sensitivity_to	1.57304645
26	MP0001986_abnormal_taste_sensitivity	1.56472339
27	MP0006276_abnormal_autonomic_nervous	1.56395366
28	MP0002138_abnormal_hepatobiliary_system	1.52998721
29	MP0005646_abnormal_pituitary_gland	1.52798700
30	MP0006036_abnormal_mitochondrial_physio	1.51391980
31	MP0009745_abnormal_behavioral_response	1.42122719
32	MP0005075_abnormal_melanosome_morpholog	1.39742386
33	MP0009046_muscle_twitch	1.37401926
34	MP0001835_abnormal_antigen_presentation	1.36528264
35	MP0002876_abnormal_thyroid_physiology	1.35489454
36	MP0005671_abnormal_response_to	1.33932208
37	MP0001970_abnormal_pain_threshold	1.33164325
38	MP0002163_abnormal_gland_morphology	1.32623656
39	MP0005253_abnormal_eye_physiology	1.32437435
40	MP0000372_irregular_coat_pigmentation	1.31202589
41	MP0005367_renal/urinary_system_phenotyp	1.30264315
42	MP0000516_abnormal_urinary_system	1.30264315
43	MP0004145_abnormal_muscle_electrophysio	1.29207759
44	MP0001905_abnormal_dopamine_level	1.28175804
45	MP0003786_premature_aging	1.28016915
46	MP0005389_reproductive_system_phenotype	1.25443700
47	MP0004147_increased_porphyrin_level	1.24785668
48	MP0002572_abnormal_emotion/affect_behav	1.22831397
49	MP0002938_white_spotting	1.22323681
50	MP0003806_abnormal_nucleotide_metabolis	1.20314546
51	MP0001501_abnormal_sleep_pattern	1.20258434
52	MP0003880_abnormal_central_pattern	1.16914874
53	MP0002734_abnormal_mechanical_nocicepti	1.16299732
54	MP0003195_calcinosis	1.16050897
55	MP0002653_abnormal_ependyma_morphology	1.15901954
56	MP0002160_abnormal_reproductive_system	1.15403100
57	MP0001984_abnormal_olfaction	1.14405402
58	MP0001919_abnormal_reproductive_system	1.13528851
59	MP0002557_abnormal_social/conspecific_i	1.13024750
60	MP0005379_endocrine/exocrine_gland_phen	1.11907692
61	MP0001440_abnormal_grooming_behavior	1.11698355
62	MP0003186_abnormal_redox_activity	1.11255707
63	MP0004043_abnormal_pH_regulation	1.09030827
64	MP0001800_abnormal_humoral_immune	1.08598408
65	MP0004742_abnormal_vestibular_system	1.07353290
66	MP0002733_abnormal_thermal_nociception	1.07094131
67	MP0005670_abnormal_white_adipose	1.05329165
68	MP0001486_abnormal_startle_reflex	1.03746184
69	MP0005410_abnormal_fertilization	1.02693306
70	MP0008058_abnormal_DNA_repair	1.02309181
71	MP0008775_abnormal_heart_ventricle	1.02251082
72	MP0002067_abnormal_sensory_capabilities	1.00822097
73	MP0003718_maternal_effect	0.99671987
74	MP0002148_abnormal_hypersensitivity_rea	0.98912556
75	MP0002095_abnormal_skin_pigmentation	0.97348069
76	MP0001873_stomach_inflammation	0.96064294
77	MP0003252_abnormal_bile_duct	0.91851042
78	MP0005174_abnormal_tail_pigmentation	0.90001524
79	MP0006035_abnormal_mitochondrial_morpho	0.86442319
80	MP0005195_abnormal_posterior_eye	0.82108866
81	MP0000230_abnormal_systemic_arterial	0.82017778
82	MP0008007_abnormal_cellular_replicative	0.81336445
83	MP0003315_abnormal_perineum_morphology	0.80429217
84	MP0005084_abnormal_gallbladder_morpholo	0.79221559
85	MP0005636_abnormal_mineral_homeostasis	0.79006387
86	MP0000685_abnormal_immune_system	0.78813644
87	MP0003635_abnormal_synaptic_transmissio	0.77818941
88	MP0000778_abnormal_nervous_system	0.77465120
89	MP0004924_abnormal_behavior	0.75600634
90	MP0005386_behavior/neurological_phenoty	0.75600634
91	MP0008789_abnormal_olfactory_epithelium	0.75511095
92	MP0002638_abnormal_pupillary_reflex	0.74899085
93	MP0002184_abnormal_innervation	0.74557982
94	MP0002063_abnormal_learning/memory/cond	0.74364943
95	MP0009333_abnormal_splenocyte_physiolog	0.73971275
96	MP0002234_abnormal_pharynx_morphology	0.72737857
97	MP0000427_abnormal_hair_cycle	0.72365721
98	MP0002229_neurodegeneration	0.72098988
99	MP0004133_heterotaxia	0.71614276
100	MP0001929_abnormal_gametogenesis	0.70790008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.53901047
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.00189450
3	Acute encephalopathy (HP:0006846)	3.86981301
4	Mitochondrial inheritance (HP:0001427)	3.79853495
5	Reticulocytopenia (HP:0001896)	3.78116094
6	Progressive macrocephaly (HP:0004481)	3.76773783
7	3-Methylglutaconic aciduria (HP:0003535)	3.69795186
8	Increased CSF lactate (HP:0002490)	3.42737602
9	Hepatocellular necrosis (HP:0001404)	3.13388564
10	Congenital stationary night blindness (HP:0007642)	3.12300312
11	Absent thumb (HP:0009777)	3.09211965
12	Abnormality of midbrain morphology (HP:0002418)	3.00667532
13	Molar tooth sign on MRI (HP:0002419)	3.00667532
14	Pancreatic cysts (HP:0001737)	2.98205690
15	Abnormality of DNA repair (HP:0003254)	2.96349740
16	Type II lissencephaly (HP:0007260)	2.89614068
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.89046061
18	Optic disc pallor (HP:0000543)	2.88737355
19	Pancreatic fibrosis (HP:0100732)	2.86889983
20	Hepatic necrosis (HP:0002605)	2.86884599
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86713284
22	Abolished electroretinogram (ERG) (HP:0000550)	2.74353293
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.69314552
24	Congenital, generalized hypertrichosis (HP:0004540)	2.69140956
25	Cerebral edema (HP:0002181)	2.68057810
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.57226769
27	Type I transferrin isoform profile (HP:0003642)	2.54667171
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.54397993
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.54397993
30	Medial flaring of the eyebrow (HP:0010747)	2.52952763
31	Abnormality of the renal cortex (HP:0011035)	2.52642634
32	Asplenia (HP:0001746)	2.46073655
33	Hypoplasia of the pons (HP:0012110)	2.45352188
34	Nephronophthisis (HP:0000090)	2.44894788
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42258088
36	Absent/shortened dynein arms (HP:0200106)	2.42258088
37	Abnormality of the pons (HP:0007361)	2.40736646
38	Pendular nystagmus (HP:0012043)	2.38875810
39	Stomatitis (HP:0010280)	2.36120480
40	Abnormal drinking behavior (HP:0030082)	2.34534230
41	Polydipsia (HP:0001959)	2.34534230
42	Lactic acidosis (HP:0003128)	2.34035828
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.28469186
44	Abnormal number of erythroid precursors (HP:0012131)	2.25753714
45	Hypoproteinemia (HP:0003075)	2.23991518
46	Supernumerary spleens (HP:0009799)	2.22668602
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20317672
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19359398
49	Increased serum lactate (HP:0002151)	2.19211187
50	Leukodystrophy (HP:0002415)	2.18761279
51	Increased hepatocellular lipid droplets (HP:0006565)	2.18088509
52	Abnormality of the renal collecting system (HP:0004742)	2.16351454
53	Abnormality of the renal medulla (HP:0100957)	2.15963797
54	Cerebellar dysplasia (HP:0007033)	2.14107330
55	Reduced antithrombin III activity (HP:0001976)	2.12193532
56	Abnormality of the prostate (HP:0008775)	2.11425895
57	Renal cortical cysts (HP:0000803)	2.10063179
58	Keratoconus (HP:0000563)	2.07385272
59	Increased corneal curvature (HP:0100692)	2.07385272
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06530045
61	Lipid accumulation in hepatocytes (HP:0006561)	2.05355099
62	Macrocytic anemia (HP:0001972)	2.02241590
63	Methylmalonic acidemia (HP:0002912)	2.02157198
64	Bile duct proliferation (HP:0001408)	2.01970734
65	Abnormal biliary tract physiology (HP:0012439)	2.01970734
66	Duplicated collecting system (HP:0000081)	1.99286153
67	Renal Fanconi syndrome (HP:0001994)	1.98995540
68	Polyuria (HP:0000103)	1.96800688
69	Sclerocornea (HP:0000647)	1.96345266
70	Ketosis (HP:0001946)	1.95351407
71	True hermaphroditism (HP:0010459)	1.93444681
72	Lethargy (HP:0001254)	1.93428392
73	Abnormality of the ileum (HP:0001549)	1.91513461
74	Abnormality of alanine metabolism (HP:0010916)	1.90961175
75	Hyperalaninemia (HP:0003348)	1.90961175
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90961175
77	Lissencephaly (HP:0001339)	1.90401564
78	Respiratory failure (HP:0002878)	1.90290733
79	Meckel diverticulum (HP:0002245)	1.89211504
80	Increased intramyocellular lipid droplets (HP:0012240)	1.89160273
81	IgG deficiency (HP:0004315)	1.88608595
82	Abnormal protein glycosylation (HP:0012346)	1.88362003
83	Abnormal glycosylation (HP:0012345)	1.88362003
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88362003
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.88362003
86	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87559057
87	Oligomenorrhea (HP:0000876)	1.87324505
88	Attenuation of retinal blood vessels (HP:0007843)	1.87265080
89	Abnormality of the labia minora (HP:0012880)	1.85543735
90	Hypomagnesemia (HP:0002917)	1.84261487
91	Cystic liver disease (HP:0006706)	1.83856029
92	Pallor (HP:0000980)	1.83442409
93	Decreased central vision (HP:0007663)	1.82091527
94	Exercise intolerance (HP:0003546)	1.80170008
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.77112522
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77112522
97	Adrenal hypoplasia (HP:0000835)	1.76323494
98	Abnormality of the preputium (HP:0100587)	1.76259042
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75047466
100	X-linked dominant inheritance (HP:0001423)	1.73004068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.60626301
2	NUAK1	3.26085403
3	ADRBK2	2.84126478
4	VRK2	2.67599575
5	TLK1	2.62400112
6	BCKDK	2.57644884
7	ZAK	2.42588573
8	TAOK3	2.41646084
9	FRK	2.40549241
10	WNK3	2.30297766
11	PINK1	2.21997539
12	GRK1	2.19899609
13	CDK19	2.15077181
14	DYRK2	2.14523839
15	TXK	1.90028243
16	STK16	1.83386007
17	PLK4	1.83262632
18	MAPK13	1.78232835
19	VRK1	1.68425642
20	MAP4K2	1.67220390
21	CAMKK2	1.64027208
22	PHKG2	1.62311163
23	PHKG1	1.62311163
24	OXSR1	1.60166415
25	STK39	1.49098735
26	MUSK	1.21906857
27	MARK1	1.18148184
28	BCR	1.17997689
29	MAP4K1	1.15619279
30	TIE1	1.14570893
31	PRKCG	1.10749677
32	GRK6	1.08404827
33	TEC	1.04694742
34	SYK	1.04066186
35	MST4	0.98619433
36	ITK	0.97361133
37	CSNK1G2	0.95457438
38	PLK2	0.94496600
39	TNIK	0.90762981
40	IKBKB	0.85815757
41	MAP3K12	0.81812806
42	INSRR	0.81231139
43	DAPK2	0.79273055
44	PASK	0.78327008
45	MAP3K4	0.78024934
46	MAP2K6	0.75956448
47	BMPR1B	0.75165711
48	MAP2K7	0.73839338
49	ADRBK1	0.73632822
50	FES	0.73503163
51	CAMKK1	0.72001198
52	IKBKE	0.71179312
53	PIK3CA	0.70029145
54	MAP3K11	0.69554576
55	STK11	0.66824085
56	KIT	0.65599597
57	NME1	0.65273617
58	PRKCE	0.65165198
59	ATR	0.64577736
60	CSNK1G3	0.64401534
61	CDK3	0.63415594
62	TNK2	0.62989422
63	LYN	0.61473562
64	PRKCQ	0.58379412
65	PRKACA	0.57643882
66	MAP2K2	0.57385111
67	BTK	0.56076744
68	MKNK1	0.55999199
69	MAPKAPK5	0.55595641
70	PLK3	0.55323280
71	GRK5	0.55128665
72	EPHA4	0.52424064
73	CSF1R	0.51121113
74	RPS6KA5	0.50712749
75	PAK3	0.50174634
76	OBSCN	0.49671790
77	CAMK1	0.49345003
78	TRIM28	0.48296574
79	PRKCD	0.45664766
80	DYRK1A	0.43572135
81	CSNK1A1L	0.42800544
82	CASK	0.42658871
83	LCK	0.42019592
84	EPHB2	0.41722336
85	PRKCA	0.41221297
86	CAMK2A	0.41057133
87	CHEK2	0.40846406
88	EIF2AK1	0.39865497
89	ABL2	0.38061285
90	MAP3K14	0.37971774
91	FLT3	0.37803534
92	CSNK2A2	0.37343514
93	CDK8	0.37163144
94	NTRK2	0.36883807
95	CSNK1A1	0.36604600
96	DAPK3	0.36489013
97	PRKG1	0.36073212
98	CSNK1G1	0.35604514
99	MINK1	0.35383164
100	ATM	0.35179094

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.84653661
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.74659081
3	Asthma_Homo sapiens_hsa05310	3.28128688
4	Parkinsons disease_Homo sapiens_hsa05012	3.12105625
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.74653849
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.49253316
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45262093
8	Allograft rejection_Homo sapiens_hsa05330	2.32706320
9	Proteasome_Homo sapiens_hsa03050	2.22380639
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.19829798
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13355097
12	Alzheimers disease_Homo sapiens_hsa05010	2.12153475
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.09368926
14	Huntingtons disease_Homo sapiens_hsa05016	2.00934554
15	Protein export_Homo sapiens_hsa03060	2.00654491
16	RNA polymerase_Homo sapiens_hsa03020	1.99685133
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98464919
18	Homologous recombination_Homo sapiens_hsa03440	1.98370050
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.93463545
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89019007
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.80300708
22	RNA degradation_Homo sapiens_hsa03018	1.71283062
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68135790
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66433999
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.65136484
26	Phototransduction_Homo sapiens_hsa04744	1.42383736
27	Basal transcription factors_Homo sapiens_hsa03022	1.29420808
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.26947903
29	Nicotine addiction_Homo sapiens_hsa05033	1.26672548
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23877850
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.21914019
32	Olfactory transduction_Homo sapiens_hsa04740	1.20265541
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.18869140
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.17326434
35	Butanoate metabolism_Homo sapiens_hsa00650	1.12392443
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06388970
37	Propanoate metabolism_Homo sapiens_hsa00640	1.02795453
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.99523203
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96711166
40	One carbon pool by folate_Homo sapiens_hsa00670	0.96627812
41	Taste transduction_Homo sapiens_hsa04742	0.94241068
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.92793276
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91238770
44	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88648953
45	Peroxisome_Homo sapiens_hsa04146	0.88361116
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.88256408
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87955925
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86887037
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83432825
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82975580
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81390896
52	Mismatch repair_Homo sapiens_hsa03430	0.79412119
53	Purine metabolism_Homo sapiens_hsa00230	0.79197686
54	Morphine addiction_Homo sapiens_hsa05032	0.78004015
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77763606
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77304440
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77101747
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76355285
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73562275
60	Caffeine metabolism_Homo sapiens_hsa00232	0.72591697
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71264279
62	Retinol metabolism_Homo sapiens_hsa00830	0.68085297
63	Metabolic pathways_Homo sapiens_hsa01100	0.67666711
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64484681
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.63466618
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62004910
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56050009
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55843536
69	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53815750
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53741396
71	RNA transport_Homo sapiens_hsa03013	0.53490472
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52445986
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52174748
74	Spliceosome_Homo sapiens_hsa03040	0.51975317
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51755342
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50623835
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50496578
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48205781
79	Regulation of autophagy_Homo sapiens_hsa04140	0.45596432
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44464845
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44094633
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43178397
83	GABAergic synapse_Homo sapiens_hsa04727	0.42711986
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41577671
85	Insulin secretion_Homo sapiens_hsa04911	0.39736678
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39123521
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.38530623
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.35517529
89	Salivary secretion_Homo sapiens_hsa04970	0.35034721
90	Fatty acid elongation_Homo sapiens_hsa00062	0.32668789
91	Serotonergic synapse_Homo sapiens_hsa04726	0.32282548
92	Sulfur metabolism_Homo sapiens_hsa00920	0.32081148
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31537016
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31042627
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29079204
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.27535986
97	Fatty acid degradation_Homo sapiens_hsa00071	0.26600611
98	Viral myocarditis_Homo sapiens_hsa05416	0.26012049
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.24954823
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24544141

RPL9P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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