RPL9P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.36892654
2viral transcription (GO:0019083)5.92823826
3translational termination (GO:0006415)5.79571703
4translational elongation (GO:0006414)5.20194010
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.91480146
6maturation of SSU-rRNA (GO:0030490)4.88710254
7cotranslational protein targeting to membrane (GO:0006613)4.82900085
8protein targeting to ER (GO:0045047)4.78310183
9ribosomal large subunit biogenesis (GO:0042273)4.68567140
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.60683560
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.56407156
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.56407156
13protein localization to endoplasmic reticulum (GO:0070972)4.52914790
14protein complex biogenesis (GO:0070271)4.41226190
15DNA deamination (GO:0045006)4.36903770
16cellular protein complex disassembly (GO:0043624)4.34518853
17ribosomal small subunit biogenesis (GO:0042274)4.33630260
18ATP synthesis coupled proton transport (GO:0015986)4.28523093
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28523093
20protein neddylation (GO:0045116)4.19759808
21viral life cycle (GO:0019058)4.16944593
22mitochondrial respiratory chain complex assembly (GO:0033108)4.06873328
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99863580
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.99863580
25NADH dehydrogenase complex assembly (GO:0010257)3.99863580
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99498304
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86305365
28nucleotide salvage (GO:0043173)3.79606704
29CTP metabolic process (GO:0046036)3.76876970
30CTP biosynthetic process (GO:0006241)3.76876970
31chaperone-mediated protein transport (GO:0072321)3.67313164
32translational initiation (GO:0006413)3.66459273
33protein complex disassembly (GO:0043241)3.59810641
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57039492
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52985329
36macromolecular complex disassembly (GO:0032984)3.40755775
37pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.39658120
38pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.38249782
39nucleoside salvage (GO:0043174)3.36165854
40water-soluble vitamin biosynthetic process (GO:0042364)3.35485499
41pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.34702402
42pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.33603408
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.33130884
44translation (GO:0006412)3.31304330
45behavioral response to nicotine (GO:0035095)3.27941786
46purine nucleotide salvage (GO:0032261)3.20799469
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19346371
48respiratory chain complex IV assembly (GO:0008535)3.17437967
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13869387
50protein targeting to membrane (GO:0006612)3.12356939
51epithelial cilium movement (GO:0003351)3.10225182
52cytochrome complex assembly (GO:0017004)3.09056873
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07850510
54kynurenine metabolic process (GO:0070189)3.00909249
55electron transport chain (GO:0022900)3.00128632
56respiratory electron transport chain (GO:0022904)2.99342538
57nuclear-transcribed mRNA catabolic process (GO:0000956)2.98299342
58GTP biosynthetic process (GO:0006183)2.97835056
59dentate gyrus development (GO:0021542)2.91726795
60cellular component biogenesis (GO:0044085)2.90941888
61protein-cofactor linkage (GO:0018065)2.84710389
62substrate-independent telencephalic tangential migration (GO:0021826)2.83507005
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83507005
64behavioral response to ethanol (GO:0048149)2.83296617
65negative regulation of mast cell activation (GO:0033004)2.81160350
66intraciliary transport (GO:0042073)2.80843844
67mRNA catabolic process (GO:0006402)2.79572961
68protein localization to cilium (GO:0061512)2.75429200
69platelet dense granule organization (GO:0060155)2.74855921
70detection of light stimulus involved in visual perception (GO:0050908)2.73929739
71detection of light stimulus involved in sensory perception (GO:0050962)2.73929739
72regulation of meiosis I (GO:0060631)2.71673394
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70109056
74pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.69318901
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67943447
76aggressive behavior (GO:0002118)2.66757257
77tryptophan catabolic process (GO:0006569)2.65789608
78indole-containing compound catabolic process (GO:0042436)2.65789608
79indolalkylamine catabolic process (GO:0046218)2.65789608
80pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.64604538
81parturition (GO:0007567)2.62398687
82indolalkylamine metabolic process (GO:0006586)2.61610270
83pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.61105231
84UMP metabolic process (GO:0046049)2.61105231
85pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.61105231
86UMP biosynthetic process (GO:0006222)2.61105231
87cell proliferation in forebrain (GO:0021846)2.60936709
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60813800
89cellular ketone body metabolic process (GO:0046950)2.58639595
90UTP metabolic process (GO:0046051)2.56704146
91glycerophospholipid catabolic process (GO:0046475)2.55978050
92pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.55271223
93RNA catabolic process (GO:0006401)2.55066614
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54524023
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.53905329
96segment specification (GO:0007379)2.53258656
97keratinocyte development (GO:0003334)2.51215482
98head development (GO:0060322)2.51126905
99pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.50886403
100hydrogen ion transmembrane transport (GO:1902600)2.50759852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.43232255
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17708996
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.14564058
4ZNF274_21170338_ChIP-Seq_K562_Hela2.82358530
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64205317
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62301368
7IGF1R_20145208_ChIP-Seq_DFB_Human2.60891269
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.52039037
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.44395450
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36316753
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33007437
12IRF1_19129219_ChIP-ChIP_H3396_Human2.15224468
13VDR_22108803_ChIP-Seq_LS180_Human2.00991840
14GBX2_23144817_ChIP-Seq_PC3_Human1.95249001
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.89297526
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85481852
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84480901
18VDR_23849224_ChIP-Seq_CD4+_Human1.83759433
19EWS_26573619_Chip-Seq_HEK293_Human1.83580374
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83277623
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82679813
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74787548
23ELK1_19687146_ChIP-ChIP_HELA_Human1.74607722
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73537924
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72326016
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69692521
27FUS_26573619_Chip-Seq_HEK293_Human1.68812838
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65133316
29MYC_18940864_ChIP-ChIP_HL60_Human1.64284917
30TP53_22573176_ChIP-Seq_HFKS_Human1.62578099
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53931133
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53275972
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52997479
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52296122
35P300_19829295_ChIP-Seq_ESCs_Human1.52128850
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51732241
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43607845
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.40496794
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36456933
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.35215075
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35122198
42FOXP3_21729870_ChIP-Seq_TREG_Human1.34315135
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.34020399
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31182222
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30617079
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.30617079
47NCOR_22424771_ChIP-Seq_293T_Human1.28856712
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28289425
49CBP_20019798_ChIP-Seq_JUKART_Human1.28289425
50ER_23166858_ChIP-Seq_MCF-7_Human1.28013637
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27216202
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26374761
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24898042
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.23675955
55REST_21632747_ChIP-Seq_MESCs_Mouse1.22873356
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22356734
57RNF2_27304074_Chip-Seq_NSC_Mouse1.21659823
58SOX2_19829295_ChIP-Seq_ESCs_Human1.21437726
59NANOG_19829295_ChIP-Seq_ESCs_Human1.21437726
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21266948
61AR_20517297_ChIP-Seq_VCAP_Human1.18996713
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.18705949
63TAF2_19829295_ChIP-Seq_ESCs_Human1.17573483
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16741941
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.16061380
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15815477
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15367061
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14747812
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14655562
70MYC_19829295_ChIP-Seq_ESCs_Human1.12243646
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11981040
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.11880755
73NANOG_20526341_ChIP-Seq_ESCs_Human1.11244407
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.09199428
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08465863
76TAF15_26573619_Chip-Seq_HEK293_Human1.08103594
77TTF2_22483619_ChIP-Seq_HELA_Human1.08064514
78HTT_18923047_ChIP-ChIP_STHdh_Human1.07224323
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.05908563
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03558839
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.03167008
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02615414
83RUNX2_22187159_ChIP-Seq_PCA_Human1.02571266
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02460605
85ERA_21632823_ChIP-Seq_H3396_Human1.02067444
86BCAT_22108803_ChIP-Seq_LS180_Human1.01762180
87TCF4_22108803_ChIP-Seq_LS180_Human0.99127381
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98386482
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97675324
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95959942
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95934638
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95496038
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95034639
94P53_21459846_ChIP-Seq_SAOS-2_Human0.93626784
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.93457384
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91975025
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90098996
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.89769594
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89609113
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.89196985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.92166336
2MP0006292_abnormal_olfactory_placode3.76154716
3MP0008875_abnormal_xenobiotic_pharmacok2.89112167
4MP0003646_muscle_fatigue2.80249818
5MP0002163_abnormal_gland_morphology2.60730004
6MP0005645_abnormal_hypothalamus_physiol2.55494112
7MP0002837_dystrophic_cardiac_calcinosis2.27402068
8MP0002102_abnormal_ear_morphology2.17977953
9MP0006072_abnormal_retinal_apoptosis2.12208286
10MP0004142_abnormal_muscle_tone2.00608422
11MP0008877_abnormal_DNA_methylation1.97136572
12MP0003787_abnormal_imprinting1.95885875
13MP0005379_endocrine/exocrine_gland_phen1.93544391
14MP0008872_abnormal_physiological_respon1.93473438
15MP0004885_abnormal_endolymph1.89059532
16MP0005084_abnormal_gallbladder_morpholo1.79822552
17MP0003195_calcinosis1.78701962
18MP0001986_abnormal_taste_sensitivity1.78410236
19MP0003011_delayed_dark_adaptation1.78145186
20MP0005551_abnormal_eye_electrophysiolog1.70950603
21MP0001348_abnormal_lacrimal_gland1.68255432
22MP0005389_reproductive_system_phenotype1.64225449
23MP0005646_abnormal_pituitary_gland1.63478127
24MP0001968_abnormal_touch/_nociception1.63363391
25MP0002160_abnormal_reproductive_system1.61901665
26MP0002138_abnormal_hepatobiliary_system1.61245399
27MP0001293_anophthalmia1.53888989
28MP0006276_abnormal_autonomic_nervous1.53567494
29MP0003806_abnormal_nucleotide_metabolis1.47575569
30MP0008995_early_reproductive_senescence1.44166662
31MP0002272_abnormal_nervous_system1.44052471
32MP0003122_maternal_imprinting1.43141480
33MP0001529_abnormal_vocalization1.39606026
34MP0008789_abnormal_olfactory_epithelium1.39510766
35MP0003880_abnormal_central_pattern1.37024726
36MP0004043_abnormal_pH_regulation1.32021085
37MP0001919_abnormal_reproductive_system1.28209748
38MP0002736_abnormal_nociception_after1.27546642
39MP0001905_abnormal_dopamine_level1.26624191
40MP0002938_white_spotting1.22846504
41MP0005671_abnormal_response_to1.22753926
42MP0005253_abnormal_eye_physiology1.22684674
43MP0002653_abnormal_ependyma_morphology1.20446295
44MP0005167_abnormal_blood-brain_barrier1.20124356
45MP0002095_abnormal_skin_pigmentation1.19227248
46MP0008775_abnormal_heart_ventricle1.18027209
47MP0005174_abnormal_tail_pigmentation1.13907479
48MP0002638_abnormal_pupillary_reflex1.13722612
49MP0002876_abnormal_thyroid_physiology1.12824461
50MP0009745_abnormal_behavioral_response1.12539350
51MP0001501_abnormal_sleep_pattern1.10354623
52MP0002822_catalepsy1.08696774
53MP0000631_abnormal_neuroendocrine_gland1.04999776
54MP0009046_muscle_twitch1.03825966
55MP0002557_abnormal_social/conspecific_i1.03800505
56MP0001970_abnormal_pain_threshold1.03778683
57MP0005085_abnormal_gallbladder_physiolo1.01821691
58MP0001485_abnormal_pinna_reflex1.01237024
59MP0008058_abnormal_DNA_repair1.00894829
60MP0002733_abnormal_thermal_nociception0.99968350
61MP0001764_abnormal_homeostasis0.99502289
62MP0002735_abnormal_chemical_nociception0.98538112
63MP0005332_abnormal_amino_acid0.97567668
64MP0001984_abnormal_olfaction0.96764757
65MP0001440_abnormal_grooming_behavior0.95727573
66MP0005195_abnormal_posterior_eye0.94424364
67MP0004145_abnormal_muscle_electrophysio0.93368577
68MP0004147_increased_porphyrin_level0.93060559
69MP0003121_genomic_imprinting0.92002665
70MP0005394_taste/olfaction_phenotype0.89949511
71MP0005499_abnormal_olfactory_system0.89949511
72MP0009764_decreased_sensitivity_to0.88635569
73MP0000372_irregular_coat_pigmentation0.87951606
74MP0005377_hearing/vestibular/ear_phenot0.87724123
75MP0003878_abnormal_ear_physiology0.87724123
76MP0002572_abnormal_emotion/affect_behav0.86425100
77MP0005423_abnormal_somatic_nervous0.86061236
78MP0001486_abnormal_startle_reflex0.85980248
79MP0003186_abnormal_redox_activity0.85695746
80MP0000049_abnormal_middle_ear0.85280611
81MP0003567_abnormal_fetal_cardiomyocyte0.83397827
82MP0003252_abnormal_bile_duct0.82967865
83MP0002752_abnormal_somatic_nervous0.82862889
84MP0000230_abnormal_systemic_arterial0.82660204
85MP0001663_abnormal_digestive_system0.80971564
86MP0000026_abnormal_inner_ear0.78967558
87MP0005075_abnormal_melanosome_morpholog0.77723534
88MP0003635_abnormal_synaptic_transmissio0.76687430
89MP0002928_abnormal_bile_duct0.76232445
90MP0005360_urolithiasis0.76176750
91MP0005410_abnormal_fertilization0.75963652
92MP0000427_abnormal_hair_cycle0.75043496
93MP0001835_abnormal_antigen_presentation0.74933855
94MP0002184_abnormal_innervation0.74805065
95MP0003123_paternal_imprinting0.73770959
96MP0002234_abnormal_pharynx_morphology0.72803579
97MP0000778_abnormal_nervous_system0.71280937
98MP0001873_stomach_inflammation0.71262039
99MP0002210_abnormal_sex_determination0.71248195
100MP0004133_heterotaxia0.71021801

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.00807928
2Reticulocytopenia (HP:0001896)3.96452272
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.69712646
4Pancreatic cysts (HP:0001737)3.63945659
5Acute encephalopathy (HP:0006846)3.60710940
6Pancreatic fibrosis (HP:0100732)3.54788744
7Mitochondrial inheritance (HP:0001427)3.52916011
8Abnormality of midbrain morphology (HP:0002418)3.45908810
9Molar tooth sign on MRI (HP:0002419)3.45908810
10Progressive macrocephaly (HP:0004481)3.44318917
11Abnormality of cells of the erythroid lineage (HP:0012130)3.42137522
12Abnormal mitochondria in muscle tissue (HP:0008316)3.41011351
13Increased hepatocellular lipid droplets (HP:0006565)3.39342340
14Congenital stationary night blindness (HP:0007642)3.36380820
15Increased CSF lactate (HP:0002490)3.16707068
16Lipid accumulation in hepatocytes (HP:0006561)3.14227325
17Nephronophthisis (HP:0000090)3.13417016
18Abnormal rod and cone electroretinograms (HP:0008323)3.13241249
19Hyperglycinemia (HP:0002154)3.11340602
20True hermaphroditism (HP:0010459)3.10454134
21Renal Fanconi syndrome (HP:0001994)3.00176498
22Abnormal number of erythroid precursors (HP:0012131)3.00027608
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.96945124
24Asplenia (HP:0001746)2.92832700
25Macrocytic anemia (HP:0001972)2.84485390
26Hepatocellular necrosis (HP:0001404)2.74859539
27Type II lissencephaly (HP:0007260)2.70618623
28Decreased central vision (HP:0007663)2.67877467
29Abnormality of the renal medulla (HP:0100957)2.62804904
30Pendular nystagmus (HP:0012043)2.60125522
31Increased intramyocellular lipid droplets (HP:0012240)2.57039386
32Cerebral edema (HP:0002181)2.56562129
33Medial flaring of the eyebrow (HP:0010747)2.52727603
34Bile duct proliferation (HP:0001408)2.52264590
35Abnormal biliary tract physiology (HP:0012439)2.52264590
363-Methylglutaconic aciduria (HP:0003535)2.50995357
37Hepatic necrosis (HP:0002605)2.49569294
38Methylmalonic acidemia (HP:0002912)2.45779934
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44722842
40Abolished electroretinogram (ERG) (HP:0000550)2.40577805
41Supernumerary spleens (HP:0009799)2.37984919
42Absent thumb (HP:0009777)2.36808151
43Absent/shortened dynein arms (HP:0200106)2.35984687
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.35984687
45Cystic liver disease (HP:0006706)2.27386317
46Colon cancer (HP:0003003)2.27248210
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26808713
48Glycosuria (HP:0003076)2.26743609
49Abnormality of urine glucose concentration (HP:0011016)2.26743609
50Abnormality of DNA repair (HP:0003254)2.25613202
51Pallor (HP:0000980)2.23039520
52Hip dysplasia (HP:0001385)2.22823351
53Sclerocornea (HP:0000647)2.22638757
54Exertional dyspnea (HP:0002875)2.20600742
55Abnormality of renal resorption (HP:0011038)2.20446338
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.17562987
57Congenital, generalized hypertrichosis (HP:0004540)2.15270537
58Retinal dysplasia (HP:0007973)2.13238471
59Optic disc pallor (HP:0000543)2.13174027
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10952696
61Increased muscle lipid content (HP:0009058)2.07117172
62Symphalangism affecting the phalanges of the hand (HP:0009773)2.05910554
63Stenosis of the external auditory canal (HP:0000402)2.05298986
64Abnormality of the renal cortex (HP:0011035)2.04351211
65Attenuation of retinal blood vessels (HP:0007843)2.04158383
66Increased serum lactate (HP:0002151)2.03701388
67Methylmalonic aciduria (HP:0012120)1.99647891
68Poor suck (HP:0002033)1.99404696
69Lactic acidosis (HP:0003128)1.99129494
70Cerebellar dysplasia (HP:0007033)1.97118936
71Polydipsia (HP:0001959)1.97052403
72Abnormal drinking behavior (HP:0030082)1.97052403
73Abnormal respiratory motile cilium physiology (HP:0012261)1.93981641
74Congenital hepatic fibrosis (HP:0002612)1.93195721
75Gait imbalance (HP:0002141)1.92682461
76Tubular atrophy (HP:0000092)1.92340300
77Nephrogenic diabetes insipidus (HP:0009806)1.91122601
78Abnormal respiratory epithelium morphology (HP:0012253)1.90779324
79Abnormal respiratory motile cilium morphology (HP:0005938)1.90779324
80Congenital primary aphakia (HP:0007707)1.90638632
81Hyperphosphaturia (HP:0003109)1.90029281
82Abnormality of the proximal phalanges of the hand (HP:0009834)1.88885066
83Tachypnea (HP:0002789)1.87221825
84Lethargy (HP:0001254)1.83933933
85Hypoplasia of the pons (HP:0012110)1.83546693
86Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83313442
87Aplasia/hypoplasia of the uterus (HP:0008684)1.81698790
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80336143
89Male pseudohermaphroditism (HP:0000037)1.79875668
90Abnormality of macular pigmentation (HP:0008002)1.77511433
91Hypoplasia of the uterus (HP:0000013)1.77003954
92Constricted visual fields (HP:0001133)1.76424030
93Rib fusion (HP:0000902)1.73643074
94Delayed CNS myelination (HP:0002188)1.73638582
95Polyuria (HP:0000103)1.72455473
96Anencephaly (HP:0002323)1.71124607
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71019298
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.70736216
99Respiratory failure (HP:0002878)1.70639453
100Agitation (HP:0000713)1.70090211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.23988686
2TLK13.14664165
3ADRBK23.06410869
4CDK192.94987424
5MAP4K22.92785079
6GRK12.77448228
7PINK12.56383296
8ZAK2.56346505
9WNK42.52461171
10NUAK12.38853653
11TAOK32.33359473
12BCKDK1.98133828
13WNK31.86118201
14VRK21.74801721
15STK161.73341624
16VRK11.63653844
17LIMK11.63558096
18TXK1.58780772
19INSRR1.55732840
20DYRK21.48006070
21TIE11.41523935
22BMPR1B1.34544445
23MAP3K121.30882034
24STK38L1.26694288
25CSF1R1.22213036
26PASK1.16173870
27PRKCG1.11381255
28OXSR11.10371159
29DAPK21.10343297
30STK391.07851532
31CSNK1G11.01688646
32CSNK1G20.99674936
33PIK3CA0.94802439
34CSNK1G30.91780829
35ACVR1B0.90408380
36ADRBK10.89576436
37BCR0.86368675
38SYK0.83863390
39IKBKB0.83266699
40RPS6KA50.82994819
41MAPK130.82694024
42FES0.82509152
43MAP4K10.82098925
44PAK30.82024348
45PHKG10.80050469
46PHKG20.80050469
47KIT0.79397397
48TEC0.77285410
49TNK20.75781079
50PLK20.75480919
51DAPK30.75349033
52GRK70.74924385
53EPHA40.74784060
54OBSCN0.73009221
55MYLK0.72893610
56CAMK10.72471512
57MAP3K110.71328423
58MST40.70568338
59PLK40.70353746
60CAMKK20.69084917
61EIF2AK30.68455637
62AURKA0.68119645
63PRKCE0.66536131
64PRKCQ0.64278439
65PBK0.63474300
66NTRK20.62738202
67PRKACA0.59663327
68TGFBR10.59157919
69MINK10.58535760
70CSNK1A1L0.58370631
71IKBKE0.58331157
72MUSK0.56721141
73PLK10.56483825
74PLK30.55758859
75STK110.55692193
76CDC70.55231837
77CSNK1A10.54716431
78ITK0.53638743
79CSNK2A20.51933846
80STK240.51194115
81PRKCA0.50570398
82MAP3K40.49735125
83LYN0.48157150
84CSNK2A10.45905712
85GRK50.45406749
86PKN10.44500543
87ERBB30.44064433
88CDK30.43775010
89NTRK30.41592373
90LCK0.41438796
91CAMK2A0.39800695
92IGF1R0.39756496
93MAP2K60.39270190
94BTK0.38806791
95PAK60.38492353
96DAPK10.36539028
97KDR0.35740766
98BMPR20.35168094
99DYRK1A0.34246107
100EIF2AK10.33228002

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.82976850
2Oxidative phosphorylation_Homo sapiens_hsa001903.26350002
3Asthma_Homo sapiens_hsa053102.78101864
4Parkinsons disease_Homo sapiens_hsa050122.46311431
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20843524
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17315872
7Linoleic acid metabolism_Homo sapiens_hsa005912.13485034
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.08169098
9Allograft rejection_Homo sapiens_hsa053302.05112274
10Phototransduction_Homo sapiens_hsa047441.95692946
11Proteasome_Homo sapiens_hsa030501.94053078
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93761497
13Type I diabetes mellitus_Homo sapiens_hsa049401.90818159
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87788220
15Autoimmune thyroid disease_Homo sapiens_hsa053201.86169465
16Cardiac muscle contraction_Homo sapiens_hsa042601.80782019
17Alzheimers disease_Homo sapiens_hsa050101.78568193
18Sulfur relay system_Homo sapiens_hsa041221.73486874
19Butanoate metabolism_Homo sapiens_hsa006501.65189194
20Huntingtons disease_Homo sapiens_hsa050161.63554081
21Protein export_Homo sapiens_hsa030601.60771776
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59002374
23RNA polymerase_Homo sapiens_hsa030201.58289564
24Caffeine metabolism_Homo sapiens_hsa002321.57829744
25Graft-versus-host disease_Homo sapiens_hsa053321.51012096
26RNA degradation_Homo sapiens_hsa030181.45497559
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40650934
28Propanoate metabolism_Homo sapiens_hsa006401.37453881
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34888778
30Arachidonic acid metabolism_Homo sapiens_hsa005901.28260992
31Primary immunodeficiency_Homo sapiens_hsa053401.25592903
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22694651
33Pyrimidine metabolism_Homo sapiens_hsa002401.21519611
34Nitrogen metabolism_Homo sapiens_hsa009101.20359664
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.17237439
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15671269
37Peroxisome_Homo sapiens_hsa041461.14566998
38Fanconi anemia pathway_Homo sapiens_hsa034601.13545916
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11328898
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10411414
41Homologous recombination_Homo sapiens_hsa034401.10211663
42Nicotine addiction_Homo sapiens_hsa050331.09260334
43Chemical carcinogenesis_Homo sapiens_hsa052041.04793339
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04764965
45Tryptophan metabolism_Homo sapiens_hsa003801.04344722
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.03352185
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03246223
48One carbon pool by folate_Homo sapiens_hsa006700.99645866
49Olfactory transduction_Homo sapiens_hsa047400.97931274
50Ether lipid metabolism_Homo sapiens_hsa005650.97783434
51Retinol metabolism_Homo sapiens_hsa008300.94120965
52Fatty acid elongation_Homo sapiens_hsa000620.91706032
53Purine metabolism_Homo sapiens_hsa002300.90708914
54Fat digestion and absorption_Homo sapiens_hsa049750.90183980
55Antigen processing and presentation_Homo sapiens_hsa046120.89904018
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.89167354
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86426013
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86416075
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86265837
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85090180
61Systemic lupus erythematosus_Homo sapiens_hsa053220.78497754
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75245264
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75082844
64Hematopoietic cell lineage_Homo sapiens_hsa046400.74750844
65Metabolic pathways_Homo sapiens_hsa011000.74453242
66Rheumatoid arthritis_Homo sapiens_hsa053230.74083253
67Salivary secretion_Homo sapiens_hsa049700.72631141
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.71220935
69Glutathione metabolism_Homo sapiens_hsa004800.69290909
70Collecting duct acid secretion_Homo sapiens_hsa049660.69105944
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.68977622
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68101631
73Taste transduction_Homo sapiens_hsa047420.64465289
74Circadian entrainment_Homo sapiens_hsa047130.58031172
75Morphine addiction_Homo sapiens_hsa050320.57894755
76Selenocompound metabolism_Homo sapiens_hsa004500.57333888
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56619619
78Ovarian steroidogenesis_Homo sapiens_hsa049130.55580744
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54481289
80Serotonergic synapse_Homo sapiens_hsa047260.53079918
81Glycerolipid metabolism_Homo sapiens_hsa005610.52585489
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50978537
83Nucleotide excision repair_Homo sapiens_hsa034200.49902346
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47933000
85Basal transcription factors_Homo sapiens_hsa030220.46838842
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46652736
87beta-Alanine metabolism_Homo sapiens_hsa004100.45904508
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45346232
89Insulin secretion_Homo sapiens_hsa049110.44683154
90Glutamatergic synapse_Homo sapiens_hsa047240.44373286
91GABAergic synapse_Homo sapiens_hsa047270.44358348
92Staphylococcus aureus infection_Homo sapiens_hsa051500.43052278
93Fatty acid degradation_Homo sapiens_hsa000710.42050016
94RNA transport_Homo sapiens_hsa030130.37426550
95Regulation of autophagy_Homo sapiens_hsa041400.34167933
96Folate biosynthesis_Homo sapiens_hsa007900.32307475
97Sulfur metabolism_Homo sapiens_hsa009200.30378256
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.29395674
99Arginine and proline metabolism_Homo sapiens_hsa003300.27815936
100Fatty acid metabolism_Homo sapiens_hsa012120.27568872

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