ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.46913304
2	ribosomal small subunit assembly (GO:0000028)	6.37025785
3	ATP synthesis coupled proton transport (GO:0015986)	6.30833720
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.30833720
5	translational termination (GO:0006415)	6.22699340
6	protein neddylation (GO:0045116)	5.72681823
7	maturation of SSU-rRNA (GO:0030490)	5.51385451
8	chaperone-mediated protein transport (GO:0072321)	5.41498862
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.41446138
10	cotranslational protein targeting to membrane (GO:0006613)	5.32711716
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.30471811
12	protein targeting to ER (GO:0045047)	5.29801681
13	ribosomal small subunit biogenesis (GO:0042274)	5.23717873
14	translational elongation (GO:0006414)	5.17257277
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.05771191
16	protein localization to endoplasmic reticulum (GO:0070972)	5.03017606
17	behavioral response to nicotine (GO:0035095)	4.98225004
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.70265865
19	cellular protein complex disassembly (GO:0043624)	4.68821961
20	protein complex biogenesis (GO:0070271)	4.66891438
21	viral life cycle (GO:0019058)	4.66501795
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.64699036
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.50834721
24	NADH dehydrogenase complex assembly (GO:0010257)	4.50834721
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.50834721
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.43029018
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.28508290
28	translational initiation (GO:0006413)	4.21067064
29	respiratory electron transport chain (GO:0022904)	4.19335324
30	electron transport chain (GO:0022900)	4.18848529
31	preassembly of GPI anchor in ER membrane (GO:0016254)	4.12268268
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.00178047
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.00178047
34	protein complex disassembly (GO:0043241)	3.94410184
35	translation (GO:0006412)	3.78336293
36	parturition (GO:0007567)	3.77879630
37	macromolecular complex disassembly (GO:0032984)	3.75249148
38	ribosomal large subunit biogenesis (GO:0042273)	3.71926620
39	ATP biosynthetic process (GO:0006754)	3.63522956
40	protein targeting to membrane (GO:0006612)	3.61269301
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.54778762
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.51147082
43	DNA deamination (GO:0045006)	3.47504372
44	cellular component biogenesis (GO:0044085)	3.33471258
45	hydrogen ion transmembrane transport (GO:1902600)	3.29023880
46	GTP biosynthetic process (GO:0006183)	3.27088814
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.16978212
48	negative regulation of telomere maintenance (GO:0032205)	3.12186133
49	GPI anchor metabolic process (GO:0006505)	3.12013260
50	respiratory chain complex IV assembly (GO:0008535)	3.10768543
51	protein polyglutamylation (GO:0018095)	3.09172640
52	proton transport (GO:0015992)	3.06844863
53	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.03523714
54	hydrogen transport (GO:0006818)	3.03135930
55	mRNA catabolic process (GO:0006402)	2.97392317
56	GPI anchor biosynthetic process (GO:0006506)	2.96829605
57	protein-cofactor linkage (GO:0018065)	2.92414441
58	intracellular protein transmembrane import (GO:0044743)	2.91466958
59	response to redox state (GO:0051775)	2.90308510
60	protein localization to cilium (GO:0061512)	2.90019759
61	C-terminal protein lipidation (GO:0006501)	2.87883750
62	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.87711943
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.87521425
64	axoneme assembly (GO:0035082)	2.84340645
65	ribonucleoprotein complex biogenesis (GO:0022613)	2.83227083
66	hypothalamus development (GO:0021854)	2.82098740
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.79713176
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73824563
69	RNA catabolic process (GO:0006401)	2.73691447
70	fucose catabolic process (GO:0019317)	2.69497904
71	L-fucose metabolic process (GO:0042354)	2.69497904
72	L-fucose catabolic process (GO:0042355)	2.69497904
73	UTP biosynthetic process (GO:0006228)	2.69152860
74	cytochrome complex assembly (GO:0017004)	2.67304307
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.66367882
76	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.58661357
77	substrate-independent telencephalic tangential migration (GO:0021826)	2.58661357
78	rRNA metabolic process (GO:0016072)	2.57822513
79	cell proliferation in forebrain (GO:0021846)	2.57583723
80	rRNA processing (GO:0006364)	2.57476695
81	tRNA processing (GO:0008033)	2.56997612
82	negative regulation of heart rate (GO:0010459)	2.54285396
83	C-terminal protein amino acid modification (GO:0018410)	2.52004142
84	protein targeting to mitochondrion (GO:0006626)	2.50400852
85	UTP metabolic process (GO:0046051)	2.49612040
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.48490922
87	transmission of nerve impulse (GO:0019226)	2.47448530
88	synaptic transmission, cholinergic (GO:0007271)	2.47131287
89	regulation of chronic inflammatory response (GO:0002676)	2.46790764
90	positive regulation of T cell apoptotic process (GO:0070234)	2.46739704
91	head development (GO:0060322)	2.46067394
92	mannosylation (GO:0097502)	2.45722685
93	protein peptidyl-prolyl isomerization (GO:0000413)	2.45139903
94	protein targeting (GO:0006605)	2.44272903
95	positive regulation of prostaglandin secretion (GO:0032308)	2.43664468
96	pyrimidine nucleobase catabolic process (GO:0006208)	2.43635156
97	positive regulation of protein homodimerization activity (GO:0090073)	2.43523794
98	regulation of action potential (GO:0098900)	2.42414636
99	piRNA metabolic process (GO:0034587)	2.42122644
100	establishment of protein localization to mitochondrion (GO:0072655)	2.40324836

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.03417519
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75712139
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.31126138
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.23204418
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.82550784
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67650542
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65042605
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.45810016
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.35473638
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15324463
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87758431
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87691684
13	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85935319
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.84244047
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82624588
16	VDR_22108803_ChIP-Seq_LS180_Human	1.78980361
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.76543685
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75518277
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75261644
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.72773572
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72329931
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67045606
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.62605033
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61627273
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.60717616
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59628260
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59305964
28	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54642229
29	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54016339
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49896096
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45808967
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44883810
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.42414385
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40978849
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.40264393
36	EWS_26573619_Chip-Seq_HEK293_Human	1.40258282
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40005138
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38795811
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.38479034
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.37819725
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37772442
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.35083230
43	NCOR_22424771_ChIP-Seq_293T_Human	1.34263904
44	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.33393226
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.33386172
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31301118
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29001824
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.28875952
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.27579983
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27417261
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27257581
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25619263
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.23982766
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23575681
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23575681
56	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.23068187
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20523090
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19563368
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18227066
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17441900
61	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16944017
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16171861
63	ERA_21632823_ChIP-Seq_H3396_Human	1.15252061
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13908350
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12143293
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10715630
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.10402663
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.09334047
69	AR_20517297_ChIP-Seq_VCAP_Human	1.09267800
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08212356
71	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08134406
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.06554882
73	GABP_19822575_ChIP-Seq_HepG2_Human	1.05206284
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.04917817
75	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03388675
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01269567
77	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01044212
78	FUS_26573619_Chip-Seq_HEK293_Human	1.01018625
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00378078
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00287198
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00287198
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99445507
83	P300_19829295_ChIP-Seq_ESCs_Human	0.98976434
84	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.98790813
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98236971
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97518618
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96480369
88	TAF15_26573619_Chip-Seq_HEK293_Human	0.96010397
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95342865
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94528720
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.92783926
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91103796
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90796302
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89761588
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89342171
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89294457
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88060588
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.87948918
99	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.87616902
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.87208464

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.82632401
2	MP0009379_abnormal_foot_pigmentation	3.61493348
3	MP0002163_abnormal_gland_morphology	3.59111511
4	MP0003787_abnormal_imprinting	3.35844543
5	MP0008877_abnormal_DNA_methylation	3.10420275
6	MP0003646_muscle_fatigue	2.76672652
7	MP0005379_endocrine/exocrine_gland_phen	2.56345453
8	MP0004142_abnormal_muscle_tone	2.46107284
9	MP0004885_abnormal_endolymph	2.29725938
10	MP0001348_abnormal_lacrimal_gland	2.28340940
11	MP0002837_dystrophic_cardiac_calcinosis	2.24350382
12	MP0008875_abnormal_xenobiotic_pharmacok	2.18077943
13	MP0006276_abnormal_autonomic_nervous	2.11252075
14	MP0008789_abnormal_olfactory_epithelium	2.09463964
15	MP0008872_abnormal_physiological_respon	2.06685487
16	MP0002102_abnormal_ear_morphology	2.06314121
17	MP0002160_abnormal_reproductive_system	1.77911067
18	MP0003123_paternal_imprinting	1.77765484
19	MP0002653_abnormal_ependyma_morphology	1.76621664
20	MP0005551_abnormal_eye_electrophysiolog	1.76611039
21	MP0005646_abnormal_pituitary_gland	1.75680114
22	MP0005499_abnormal_olfactory_system	1.75661586
23	MP0005394_taste/olfaction_phenotype	1.75661586
24	MP0004147_increased_porphyrin_level	1.75336737
25	MP0004145_abnormal_muscle_electrophysio	1.74354018
26	MP0003121_genomic_imprinting	1.71211883
27	MP0002876_abnormal_thyroid_physiology	1.69907106
28	MP0003880_abnormal_central_pattern	1.68718217
29	MP0003122_maternal_imprinting	1.63932708
30	MP0000372_irregular_coat_pigmentation	1.56015623
31	MP0005389_reproductive_system_phenotype	1.54155236
32	MP0002138_abnormal_hepatobiliary_system	1.54054606
33	MP0005645_abnormal_hypothalamus_physiol	1.52856191
34	MP0006072_abnormal_retinal_apoptosis	1.41632793
35	MP0002272_abnormal_nervous_system	1.38207205
36	MP0003567_abnormal_fetal_cardiomyocyte	1.37936759
37	MP0009046_muscle_twitch	1.34366083
38	MP0005671_abnormal_response_to	1.32675054
39	MP0001968_abnormal_touch/_nociception	1.32271849
40	MP0004742_abnormal_vestibular_system	1.29852672
41	MP0000631_abnormal_neuroendocrine_gland	1.29296114
42	MP0004133_heterotaxia	1.28935471
43	MP0003315_abnormal_perineum_morphology	1.28483088
44	MP0005423_abnormal_somatic_nervous	1.26337357
45	MP0001919_abnormal_reproductive_system	1.25852528
46	MP0001440_abnormal_grooming_behavior	1.25558155
47	MP0009745_abnormal_behavioral_response	1.23925917
48	MP0002184_abnormal_innervation	1.23754694
49	MP0003878_abnormal_ear_physiology	1.22780965
50	MP0005377_hearing/vestibular/ear_phenot	1.22780965
51	MP0001905_abnormal_dopamine_level	1.19759141
52	MP0003186_abnormal_redox_activity	1.19534292
53	MP0003806_abnormal_nucleotide_metabolis	1.16385727
54	MP0000685_abnormal_immune_system	1.16256344
55	MP0003195_calcinosis	1.15677276
56	MP0001188_hyperpigmentation	1.15663548
57	MP0000778_abnormal_nervous_system	1.13763925
58	MP0000049_abnormal_middle_ear	1.13666840
59	MP0002733_abnormal_thermal_nociception	1.12556698
60	MP0001970_abnormal_pain_threshold	1.12512954
61	MP0001293_anophthalmia	1.11363550
62	MP0003011_delayed_dark_adaptation	1.11303448
63	MP0001529_abnormal_vocalization	1.11089455
64	MP0008995_early_reproductive_senescence	1.10483660
65	MP0002557_abnormal_social/conspecific_i	1.09230372
66	MP0003136_yellow_coat_color	1.09091056
67	MP0001485_abnormal_pinna_reflex	1.06199150
68	MP0009333_abnormal_splenocyte_physiolog	1.02351154
69	MP0000427_abnormal_hair_cycle	1.00789138
70	MP0002752_abnormal_somatic_nervous	1.00073142
71	MP0005195_abnormal_posterior_eye	0.99537902
72	MP0005084_abnormal_gallbladder_morpholo	0.97258066
73	MP0000955_abnormal_spinal_cord	0.95894026
74	MP0001486_abnormal_startle_reflex	0.93413205
75	MP0009764_decreased_sensitivity_to	0.93071584
76	MP0001986_abnormal_taste_sensitivity	0.92806079
77	MP0000026_abnormal_inner_ear	0.92628993
78	MP0004043_abnormal_pH_regulation	0.91328210
79	MP0002572_abnormal_emotion/affect_behav	0.88355384
80	MP0005075_abnormal_melanosome_morpholog	0.88058762
81	MP0005410_abnormal_fertilization	0.87397807
82	MP0002234_abnormal_pharynx_morphology	0.86469498
83	MP0001984_abnormal_olfaction	0.85679686
84	MP0002210_abnormal_sex_determination	0.85655897
85	MP0002638_abnormal_pupillary_reflex	0.85046839
86	MP0001963_abnormal_hearing_physiology	0.82726961
87	MP0006036_abnormal_mitochondrial_physio	0.79729662
88	MP0008775_abnormal_heart_ventricle	0.79581231
89	MP0002734_abnormal_mechanical_nocicepti	0.78835521
90	MP0001542_abnormal_bone_strength	0.78045862
91	MP0002063_abnormal_learning/memory/cond	0.76714954
92	MP0003635_abnormal_synaptic_transmissio	0.76453189
93	MP0002067_abnormal_sensory_capabilities	0.75510346
94	MP0004019_abnormal_vitamin_homeostasis	0.75029106
95	MP0000647_abnormal_sebaceous_gland	0.74932578
96	MP0005253_abnormal_eye_physiology	0.74404605
97	MP0000230_abnormal_systemic_arterial	0.73920511
98	MP0002928_abnormal_bile_duct	0.73124539
99	MP0002736_abnormal_nociception_after	0.72592373
100	MP0002095_abnormal_skin_pigmentation	0.72140038

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.80210014
2	Acute encephalopathy (HP:0006846)	4.47856675
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.32940403
4	Mitochondrial inheritance (HP:0001427)	4.17749662
5	Increased CSF lactate (HP:0002490)	3.95875153
6	Lipid accumulation in hepatocytes (HP:0006561)	3.85643614
7	Increased hepatocellular lipid droplets (HP:0006565)	3.85054784
8	Reticulocytopenia (HP:0001896)	3.83082695
9	Progressive macrocephaly (HP:0004481)	3.82182418
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.57383301
11	Renal Fanconi syndrome (HP:0001994)	3.43229047
12	3-Methylglutaconic aciduria (HP:0003535)	3.32202168
13	Hepatocellular necrosis (HP:0001404)	3.24648179
14	Type II lissencephaly (HP:0007260)	3.19401605
15	Molar tooth sign on MRI (HP:0002419)	3.17091645
16	Abnormality of midbrain morphology (HP:0002418)	3.17091645
17	Increased intramyocellular lipid droplets (HP:0012240)	3.09865159
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.99564865
19	Pancreatic cysts (HP:0001737)	2.94711008
20	Abnormal number of erythroid precursors (HP:0012131)	2.92680754
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.91449349
22	Cerebral edema (HP:0002181)	2.90125721
23	Myokymia (HP:0002411)	2.86150662
24	Macrocytic anemia (HP:0001972)	2.85425394
25	Pancreatic fibrosis (HP:0100732)	2.85196154
26	Congenital stationary night blindness (HP:0007642)	2.85159263
27	True hermaphroditism (HP:0010459)	2.83068059
28	Hepatic necrosis (HP:0002605)	2.81245393
29	Rib fusion (HP:0000902)	2.80373732
30	Nephronophthisis (HP:0000090)	2.78763742
31	Increased muscle lipid content (HP:0009058)	2.74334332
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.72052548
33	Hyperglycinemia (HP:0002154)	2.65874304
34	Medial flaring of the eyebrow (HP:0010747)	2.62384944
35	Pallor (HP:0000980)	2.53440063
36	Optic disc pallor (HP:0000543)	2.51119824
37	Increased serum lactate (HP:0002151)	2.45707178
38	Congenital, generalized hypertrichosis (HP:0004540)	2.43397600
39	Abnormality of renal resorption (HP:0011038)	2.41592484
40	Methylmalonic acidemia (HP:0002912)	2.40919934
41	Decreased central vision (HP:0007663)	2.37964034
42	Exertional dyspnea (HP:0002875)	2.36207230
43	Abnormality of the renal medulla (HP:0100957)	2.30936101
44	Abnormal drinking behavior (HP:0030082)	2.28098778
45	Polydipsia (HP:0001959)	2.28098778
46	Lactic acidosis (HP:0003128)	2.26774650
47	Adrenal hypoplasia (HP:0000835)	2.25290172
48	Stomatitis (HP:0010280)	2.23606346
49	Sclerocornea (HP:0000647)	2.23274434
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20870081
51	Bile duct proliferation (HP:0001408)	2.18066952
52	Abnormal biliary tract physiology (HP:0012439)	2.18066952
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15159929
54	Leukodystrophy (HP:0002415)	2.14543151
55	Increased IgM level (HP:0003496)	2.10184187
56	Growth hormone deficiency (HP:0000824)	2.08975879
57	Abnormality of the renal cortex (HP:0011035)	2.07140435
58	Methylmalonic aciduria (HP:0012120)	2.06441229
59	Polyuria (HP:0000103)	2.05706673
60	Abnormality of urine glucose concentration (HP:0011016)	2.05578893
61	Glycosuria (HP:0003076)	2.05578893
62	Respiratory failure (HP:0002878)	2.04651390
63	Asplenia (HP:0001746)	2.03588453
64	Male pseudohermaphroditism (HP:0000037)	2.03102637
65	Respiratory difficulties (HP:0002880)	2.00859970
66	Exercise intolerance (HP:0003546)	1.99877202
67	Type 2 muscle fiber atrophy (HP:0003554)	1.97632527
68	Lissencephaly (HP:0001339)	1.94653160
69	Tubular atrophy (HP:0000092)	1.93891152
70	Nephrogenic diabetes insipidus (HP:0009806)	1.92637148
71	Chronic hepatic failure (HP:0100626)	1.92265379
72	Gait imbalance (HP:0002141)	1.90757055
73	Neoplasm of the adrenal cortex (HP:0100641)	1.89647335
74	Lethargy (HP:0001254)	1.88348178
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87895731
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87895731
77	Abnormal hemoglobin (HP:0011902)	1.87175046
78	Abolished electroretinogram (ERG) (HP:0000550)	1.86930341
79	Concave nail (HP:0001598)	1.86386460
80	Anterior segment dysgenesis (HP:0007700)	1.86330792
81	Keratoconus (HP:0000563)	1.85886168
82	Increased corneal curvature (HP:0100692)	1.85886168
83	Hyperphosphaturia (HP:0003109)	1.84961466
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.84262662
85	Retinal dysplasia (HP:0007973)	1.82266226
86	Anomalous pulmonary venous return (HP:0010772)	1.81620286
87	Congenital primary aphakia (HP:0007707)	1.81045973
88	IgG deficiency (HP:0004315)	1.80152820
89	Cystic liver disease (HP:0006706)	1.79541567
90	Agitation (HP:0000713)	1.79528855
91	Abnormality of the labia minora (HP:0012880)	1.79177976
92	Absent thumb (HP:0009777)	1.78701910
93	Pachygyria (HP:0001302)	1.77672440
94	Pendular nystagmus (HP:0012043)	1.77572597
95	Supernumerary spleens (HP:0009799)	1.76586667
96	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.75764531
97	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.75764531
98	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.75692723
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74524700
100	Cerebellar dysplasia (HP:0007033)	1.73177849

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.50901884
2	PINK1	3.39495560
3	TLK1	2.98292458
4	MAP3K12	2.71535135
5	CDK19	2.59609522
6	TAOK3	2.56594926
7	ADRBK2	2.47074149
8	GRK1	2.29086705
9	DYRK2	2.22564927
10	ZAK	2.22085585
11	AKT3	2.11806426
12	TXK	1.96592336
13	BMPR1B	1.90623778
14	STK39	1.88565778
15	FRK	1.80593791
16	MAP3K4	1.64161193
17	MAP2K7	1.52174605
18	MAP3K9	1.50937823
19	STK16	1.46021264
20	MUSK	1.42675091
21	MAP4K2	1.42375437
22	TIE1	1.41040378
23	DAPK2	1.35764060
24	BCKDK	1.35634910
25	CASK	1.28712975
26	BRAF	1.28517675
27	VRK2	1.23061360
28	OXSR1	1.19943720
29	PAK3	1.15707662
30	PRKCG	1.15538960
31	NUAK1	1.13451403
32	PIK3CA	1.12332266
33	NME1	1.12073619
34	WNK3	1.03888576
35	DAPK3	1.02724475
36	BMPR2	1.02375331
37	MYLK	0.99305687
38	VRK1	0.97912928
39	BTK	0.95856065
40	EPHB2	0.93992782
41	WNK1	0.93299477
42	MAP3K11	0.90889010
43	MAPK13	0.89804631
44	TEC	0.89217882
45	PHKG2	0.86699700
46	PHKG1	0.86699700
47	PLK4	0.84618852
48	STK11	0.82004307
49	TYRO3	0.81961228
50	CAMK1	0.81861250
51	NTRK2	0.81036637
52	CSNK1G2	0.79742552
53	IKBKB	0.77383640
54	INSRR	0.72835543
55	TAF1	0.68686449
56	ADRBK1	0.68396941
57	PRKCQ	0.68032632
58	ITK	0.66752604
59	ARAF	0.64530505
60	NME2	0.64026909
61	MINK1	0.63588729
62	SIK2	0.63448616
63	PRKACA	0.63386398
64	NEK2	0.62323485
65	MAPKAPK3	0.61581040
66	ILK	0.61262758
67	TNIK	0.61057691
68	DAPK1	0.60351091
69	BCR	0.57922174
70	CSNK2A2	0.57802170
71	CSNK1G3	0.55879619
72	CAMKK2	0.55707047
73	EPHA4	0.55381597
74	OBSCN	0.54840790
75	MAP4K1	0.54354800
76	SYK	0.51843846
77	PRKCH	0.50129356
78	MKNK2	0.49981253
79	MAP2K4	0.46100461
80	PLK1	0.45306629
81	CSNK1G1	0.44266545
82	ACVR1B	0.43100400
83	CAMK2A	0.42971978
84	CSNK1A1	0.41872215
85	MARK1	0.41842800
86	SCYL2	0.41542580
87	TRPM7	0.41443284
88	RPS6KA5	0.41158886
89	ATR	0.41154515
90	CSNK1E	0.41144007
91	PRKCD	0.40679345
92	TRIM28	0.38914715
93	SGK494	0.38642121
94	SGK223	0.38642121
95	PRKACG	0.37286332
96	RPS6KA6	0.36768029
97	PRKCZ	0.36598957
98	PRKCA	0.36108579
99	PRKG1	0.36044926
100	SGK1	0.34796649

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.54983877
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.66658373
3	Parkinsons disease_Homo sapiens_hsa05012	3.77100322
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.39665942
5	Asthma_Homo sapiens_hsa05310	2.98727076
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.67537910
7	Alzheimers disease_Homo sapiens_hsa05010	2.66213126
8	Huntingtons disease_Homo sapiens_hsa05016	2.56934972
9	Protein export_Homo sapiens_hsa03060	2.56003514
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.49282151
11	Proteasome_Homo sapiens_hsa03050	2.48537642
12	RNA polymerase_Homo sapiens_hsa03020	2.26970842
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02327133
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89079935
15	Phototransduction_Homo sapiens_hsa04744	1.83334298
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80655461
17	Allograft rejection_Homo sapiens_hsa05330	1.77297615
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71045245
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.63490239
20	Caffeine metabolism_Homo sapiens_hsa00232	1.47312238
21	RNA degradation_Homo sapiens_hsa03018	1.41251171
22	Homologous recombination_Homo sapiens_hsa03440	1.32845200
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.27258540
24	Basal transcription factors_Homo sapiens_hsa03022	1.26758339
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18916943
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12557939
27	Olfactory transduction_Homo sapiens_hsa04740	1.10807229
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09729280
29	Nicotine addiction_Homo sapiens_hsa05033	1.05544875
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.03686104
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.02178099
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.01740929
33	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98191680
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97175255
35	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95166562
36	One carbon pool by folate_Homo sapiens_hsa00670	0.88034729
37	Primary immunodeficiency_Homo sapiens_hsa05340	0.86960330
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86899593
39	Propanoate metabolism_Homo sapiens_hsa00640	0.85485719
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82812432
41	Selenocompound metabolism_Homo sapiens_hsa00450	0.81670888
42	Butanoate metabolism_Homo sapiens_hsa00650	0.78718270
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.78328654
44	Morphine addiction_Homo sapiens_hsa05032	0.76625986
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76362617
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76069519
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75565519
48	Peroxisome_Homo sapiens_hsa04146	0.74891612
49	Purine metabolism_Homo sapiens_hsa00230	0.74548499
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72881174
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.72850060
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71245469
53	Metabolic pathways_Homo sapiens_hsa01100	0.70362003
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69415671
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67823744
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63474745
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63438300
58	Retinol metabolism_Homo sapiens_hsa00830	0.62886839
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62561352
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62258422
61	Sulfur relay system_Homo sapiens_hsa04122	0.60312267
62	Sulfur metabolism_Homo sapiens_hsa00920	0.58919745
63	Regulation of autophagy_Homo sapiens_hsa04140	0.58130479
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.57121715
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56361376
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53786624
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53549564
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53508744
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51228475
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51000724
71	RNA transport_Homo sapiens_hsa03013	0.49709290
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47727411
73	GABAergic synapse_Homo sapiens_hsa04727	0.46175429
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46124103
75	Serotonergic synapse_Homo sapiens_hsa04726	0.46014165
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44762624
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40994624
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38733625
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37782070
80	Mismatch repair_Homo sapiens_hsa03430	0.36955001
81	Spliceosome_Homo sapiens_hsa03040	0.36380026
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.36239690
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33666469
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32859183
85	Insulin secretion_Homo sapiens_hsa04911	0.32527668
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32478206
87	Taste transduction_Homo sapiens_hsa04742	0.30528815
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.30000673
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29965419
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29725586
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27744338
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27379869
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.27016976
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26966837
95	Base excision repair_Homo sapiens_hsa03410	0.26782046
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.26652818
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25692676
98	Folate biosynthesis_Homo sapiens_hsa00790	0.23935251
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.23901286
100	p53 signaling pathway_Homo sapiens_hsa04115	0.22722459

RPL9P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »