ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	somatic hypermutation of immunoglobulin genes (GO:0016446)	8.95811679
2	somatic diversification of immune receptors via somatic mutation (GO:0002566)	8.95811679
3	determination of adult lifespan (GO:0008340)	7.34610524
4	regulation of helicase activity (GO:0051095)	7.04769834
5	negative regulation of DNA recombination (GO:0045910)	5.47598749
6	replication fork processing (GO:0031297)	5.38668319
7	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	5.26242677
8	isotype switching (GO:0045190)	5.26242677
9	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	5.26242677
10	regulation of meiosis I (GO:0060631)	5.10954669
11	protein K6-linked ubiquitination (GO:0085020)	4.88480169
12	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.49596158
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.27845102
14	presynaptic membrane assembly (GO:0097105)	4.13804148
15	resolution of meiotic recombination intermediates (GO:0000712)	4.05838093
16	negative regulation of activin receptor signaling pathway (GO:0032926)	3.87236193
17	regulation of Rac protein signal transduction (GO:0035020)	3.83760905
18	positive regulation of meiosis (GO:0045836)	3.81310238
19	iron-sulfur cluster assembly (GO:0016226)	3.63199913
20	metallo-sulfur cluster assembly (GO:0031163)	3.63199913
21	DNA strand renaturation (GO:0000733)	3.59866979
22	sulfur amino acid catabolic process (GO:0000098)	3.52356630
23	histone H2A acetylation (GO:0043968)	3.51972055
24	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.51799986
25	positive regulation of meiotic cell cycle (GO:0051446)	3.50881871
26	L-methionine salvage (GO:0071267)	3.50173107
27	L-methionine biosynthetic process (GO:0071265)	3.50173107
28	amino acid salvage (GO:0043102)	3.50173107
29	behavioral response to nicotine (GO:0035095)	3.48855845
30	positive regulation of growth hormone secretion (GO:0060124)	3.47550175
31	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.46795434
32	branched-chain amino acid catabolic process (GO:0009083)	3.46051690
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.41517518
34	peroxisome fission (GO:0016559)	3.38175321
35	auditory behavior (GO:0031223)	3.38103589
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.34726794
37	protein-cofactor linkage (GO:0018065)	3.34526758
38	inositol phosphate catabolic process (GO:0071545)	3.34271448
39	regulation of B cell apoptotic process (GO:0002902)	3.31286002
40	somatic diversification of immunoglobulins (GO:0016445)	3.30237804
41	cornea development in camera-type eye (GO:0061303)	3.28004058
42	presynaptic membrane organization (GO:0097090)	3.27175008
43	pyrimidine nucleobase catabolic process (GO:0006208)	3.25769438
44	startle response (GO:0001964)	3.25071831
45	protein localization to cilium (GO:0061512)	3.16786719
46	branched-chain amino acid metabolic process (GO:0009081)	3.16333470
47	mismatch repair (GO:0006298)	3.14400326
48	oxaloacetate metabolic process (GO:0006107)	3.09075063
49	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.06361067
50	mechanosensory behavior (GO:0007638)	3.04472469
51	negative regulation of gluconeogenesis (GO:0045721)	3.00227219
52	reciprocal DNA recombination (GO:0035825)	2.99387407
53	reciprocal meiotic recombination (GO:0007131)	2.99387407
54	adult feeding behavior (GO:0008343)	2.98177222
55	negative regulation of receptor activity (GO:2000272)	2.97459611
56	methionine biosynthetic process (GO:0009086)	2.94097109
57	folic acid metabolic process (GO:0046655)	2.91815771
58	regulation of clathrin-mediated endocytosis (GO:2000369)	2.90756036
59	negative regulation of hormone biosynthetic process (GO:0032353)	2.90515892
60	negative regulation of cell aging (GO:0090344)	2.89891636
61	fatty acid homeostasis (GO:0055089)	2.89639665
62	meiotic chromosome segregation (GO:0045132)	2.88605207
63	histamine transport (GO:0051608)	2.88575776
64	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.87661282
65	receptor recycling (GO:0001881)	2.83367223
66	electron transport chain (GO:0022900)	2.81650819
67	histamine secretion (GO:0001821)	2.80186527
68	respiratory electron transport chain (GO:0022904)	2.79626996
69	limb development (GO:0060173)	2.79029442
70	appendage development (GO:0048736)	2.79029442
71	negative regulation of hormone metabolic process (GO:0032351)	2.78597966
72	histone H2B ubiquitination (GO:0033523)	2.77036449
73	prenylation (GO:0097354)	2.76951342
74	protein prenylation (GO:0018342)	2.76951342
75	nucleobase catabolic process (GO:0046113)	2.76889021
76	phenol-containing compound catabolic process (GO:0019336)	2.76857716
77	terpenoid biosynthetic process (GO:0016114)	2.69520797
78	piRNA metabolic process (GO:0034587)	2.69252435
79	DNA integration (GO:0015074)	2.69090741
80	adenosine metabolic process (GO:0046085)	2.67888593
81	C4-dicarboxylate transport (GO:0015740)	2.67224335
82	negative regulation of protein tyrosine kinase activity (GO:0061099)	2.66953415
83	response to vitamin E (GO:0033197)	2.66355231
84	cellular response to estradiol stimulus (GO:0071392)	2.65697080
85	GTP biosynthetic process (GO:0006183)	2.62174497
86	B cell activation involved in immune response (GO:0002312)	2.62157252
87	regulation of oxidative stress-induced neuron death (GO:1903203)	2.61212302
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.60173798
89	regulation of glycogen (starch) synthase activity (GO:2000465)	2.57746945
90	muscle organ morphogenesis (GO:0048644)	2.57197341
91	aerobic respiration (GO:0009060)	2.56845644
92	astrocyte development (GO:0014002)	2.56239916
93	proteasome assembly (GO:0043248)	2.54210430
94	photoperiodism (GO:0009648)	2.51047607
95	lactate metabolic process (GO:0006089)	2.50448323
96	alanine transport (GO:0032328)	2.50370076
97	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.50162702
98	entrainment of circadian clock by photoperiod (GO:0043153)	2.46879803
99	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.45834141
100	positive regulation of CREB transcription factor activity (GO:0032793)	2.45719466

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.16046134
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.60665810
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.95971360
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.57343918
5	YY1_21170310_ChIP-Seq_MESCs_Mouse	3.25191674
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19096158
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02092067
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76617707
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.61239772
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.60568940
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.45233918
12	FUS_26573619_Chip-Seq_HEK293_Human	2.41041769
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.37683456
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.33739743
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.23788608
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.17097180
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.10856110
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08477158
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08019644
20	ER_23166858_ChIP-Seq_MCF-7_Human	2.03002876
21	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.99218552
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96915442
23	VDR_22108803_ChIP-Seq_LS180_Human	1.95693360
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83402643
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.82528472
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81402207
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.78086318
28	EWS_26573619_Chip-Seq_HEK293_Human	1.77802460
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73059839
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69347453
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.61825936
32	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.60730504
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.59975178
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57318569
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.56643233
36	NCOR_22424771_ChIP-Seq_293T_Human	1.46768033
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41712643
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.40238731
39	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.40102111
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38211799
41	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36950731
42	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.36748140
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.35839796
44	SCL_19346495_ChIP-Seq_HPC-7_Human	1.35076378
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.32218745
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32125651
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30051050
48	GATA1_22025678_ChIP-Seq_K562_Human	1.29824519
49	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.28237131
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27437906
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21813608
52	GATA3_26560356_Chip-Seq_TH1_Human	1.20734896
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19132081
54	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.19059879
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17982537
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.16994019
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.16482253
58	JUN_21703547_ChIP-Seq_K562_Human	1.15859587
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15587731
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10333338
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09457453
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08981967
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07123026
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05931116
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04943341
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04518248
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.04049958
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03678937
69	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.02479150
70	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.02132446
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00788987
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99986843
73	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97823803
74	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.97093278
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96923344
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.94099293
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93566663
78	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92902034
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92343805
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91847833
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.91077706
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90853448
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.90280732
84	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.90190827
85	STAT1_20625510_ChIP-Seq_HELA_Human	0.90189477
86	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.89368047
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.88979846
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.87699646
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84589391
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.84245970
91	DCP1A_22483619_ChIP-Seq_HELA_Human	0.83771833
92	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.82876801
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82480728
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.82203327
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.82178675
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.82099242
97	RAC3_21632823_ChIP-Seq_H3396_Human	0.80930093
98	TBL1_22424771_ChIP-Seq_293T_Human	0.80061686
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.80031371
100	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.79009974

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.82048029
2	MP0008877_abnormal_DNA_methylation	3.68847176
3	MP0005084_abnormal_gallbladder_morpholo	3.45533079
4	MP0002138_abnormal_hepatobiliary_system	2.75381387
5	MP0005083_abnormal_biliary_tract	2.73477979
6	MP0003122_maternal_imprinting	2.49752155
7	MP0003787_abnormal_imprinting	2.44814427
8	MP0005645_abnormal_hypothalamus_physiol	2.34951526
9	MP0008058_abnormal_DNA_repair	2.20423789
10	MP0003283_abnormal_digestive_organ	2.16366214
11	MP0003121_genomic_imprinting	1.97683559
12	MP0008789_abnormal_olfactory_epithelium	1.96088105
13	MP0008995_early_reproductive_senescence	1.95475567
14	MP0002163_abnormal_gland_morphology	1.91808828
15	MP0002837_dystrophic_cardiac_calcinosis	1.85394403
16	MP0005499_abnormal_olfactory_system	1.80207924
17	MP0005394_taste/olfaction_phenotype	1.80207924
18	MP0005646_abnormal_pituitary_gland	1.77448052
19	MP0006054_spinal_hemorrhage	1.71062254
20	MP0002396_abnormal_hematopoietic_system	1.70617229
21	MP0005332_abnormal_amino_acid	1.67428216
22	MP0002102_abnormal_ear_morphology	1.66956835
23	MP0005367_renal/urinary_system_phenotyp	1.66655415
24	MP0000516_abnormal_urinary_system	1.66655415
25	MP0003567_abnormal_fetal_cardiomyocyte	1.63578460
26	MP0005379_endocrine/exocrine_gland_phen	1.62398135
27	MP0000372_irregular_coat_pigmentation	1.59835355
28	MP0006036_abnormal_mitochondrial_physio	1.55403345
29	MP0004147_increased_porphyrin_level	1.54336541
30	MP0003252_abnormal_bile_duct	1.54325375
31	MP0005220_abnormal_exocrine_pancreas	1.52877548
32	MP0002160_abnormal_reproductive_system	1.49495980
33	MP0001188_hyperpigmentation	1.46317968
34	MP0003942_abnormal_urinary_system	1.42378168
35	MP0000955_abnormal_spinal_cord	1.38186651
36	MP0001440_abnormal_grooming_behavior	1.37215172
37	MP0005365_abnormal_bile_salt	1.34944713
38	MP0002971_abnormal_brown_adipose	1.33186652
39	MP0005647_abnormal_sex_gland	1.32030055
40	MP0001764_abnormal_homeostasis	1.31480682
41	MP0006292_abnormal_olfactory_placode	1.27779394
42	MP0002638_abnormal_pupillary_reflex	1.27207843
43	MP0003959_abnormal_lean_body	1.27154725
44	MP0002557_abnormal_social/conspecific_i	1.26632898
45	MP0005377_hearing/vestibular/ear_phenot	1.25857673
46	MP0003878_abnormal_ear_physiology	1.25857673
47	MP0002736_abnormal_nociception_after	1.21269614
48	MP0010234_abnormal_vibrissa_follicle	1.21191615
49	MP0000631_abnormal_neuroendocrine_gland	1.19689366
50	MP0000639_abnormal_adrenal_gland	1.18793689
51	MP0002210_abnormal_sex_determination	1.15597372
52	MP0002572_abnormal_emotion/affect_behav	1.14950783
53	MP0005389_reproductive_system_phenotype	1.14873899
54	MP0000003_abnormal_adipose_tissue	1.14665284
55	MP0005551_abnormal_eye_electrophysiolog	1.13967954
56	MP0005187_abnormal_penis_morphology	1.11801912
57	MP0000647_abnormal_sebaceous_gland	1.06850921
58	MP0001727_abnormal_embryo_implantation	1.02947124
59	MP0000653_abnormal_sex_gland	1.02531208
60	MP0008875_abnormal_xenobiotic_pharmacok	1.00936019
61	MP0001145_abnormal_male_reproductive	1.00755743
62	MP0001968_abnormal_touch/_nociception	1.00422599
63	MP0005248_abnormal_Harderian_gland	0.99901737
64	MP0005397_hematopoietic_system_phenotyp	0.99539206
65	MP0001545_abnormal_hematopoietic_system	0.99539206
66	MP0001502_abnormal_circadian_rhythm	0.98878023
67	MP0005410_abnormal_fertilization	0.97936649
68	MP0009333_abnormal_splenocyte_physiolog	0.97269070
69	MP0001119_abnormal_female_reproductive	0.95902959
70	MP0003698_abnormal_male_reproductive	0.94915533
71	MP0004859_abnormal_synaptic_plasticity	0.94831439
72	MP0001191_abnormal_skin_condition	0.94721907
73	MP0004043_abnormal_pH_regulation	0.94499288
74	MP0003786_premature_aging	0.93770160
75	MP0001944_abnormal_pancreas_morphology	0.92752348
76	MP0001485_abnormal_pinna_reflex	0.92256881
77	MP0001661_extended_life_span	0.91365105
78	MP0001501_abnormal_sleep_pattern	0.91269376
79	MP0002693_abnormal_pancreas_physiology	0.90597342
80	MP0001529_abnormal_vocalization	0.89409953
81	MP0003633_abnormal_nervous_system	0.88962901
82	MP0001929_abnormal_gametogenesis	0.87393361
83	MP0005075_abnormal_melanosome_morpholog	0.83574139
84	MP0009780_abnormal_chondrocyte_physiolo	0.82956705
85	MP0005535_abnormal_body_temperature	0.82942411
86	MP0004924_abnormal_behavior	0.82516775
87	MP0005386_behavior/neurological_phenoty	0.82516775
88	MP0002063_abnormal_learning/memory/cond	0.81990709
89	MP0005423_abnormal_somatic_nervous	0.79995816
90	MP0002078_abnormal_glucose_homeostasis	0.78202180
91	MP0001486_abnormal_startle_reflex	0.77657078
92	MP0003635_abnormal_synaptic_transmissio	0.76953607
93	MP0000613_abnormal_salivary_gland	0.76478522
94	MP0005448_abnormal_energy_balance	0.76077281
95	MP0001919_abnormal_reproductive_system	0.75100949
96	MP0004145_abnormal_muscle_electrophysio	0.74836878
97	MP0003186_abnormal_redox_activity	0.74718978
98	MP0002272_abnormal_nervous_system	0.73993221
99	MP0004885_abnormal_endolymph	0.73825362
100	MP0003953_abnormal_hormone_level	0.73124971

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ependymoma (HP:0002888)	7.50366924
2	Agnosia (HP:0010524)	7.04874292
3	Astrocytoma (HP:0009592)	6.08559638
4	Abnormality of the astrocytes (HP:0100707)	6.08559638
5	Amyotrophic lateral sclerosis (HP:0007354)	5.10765064
6	Glioma (HP:0009733)	4.75785111
7	Angiofibromas (HP:0010615)	4.61326728
8	Adenoma sebaceum (HP:0009720)	4.61326728
9	Medulloblastoma (HP:0002885)	4.57151456
10	Rhabdomyosarcoma (HP:0002859)	4.37682828
11	Neoplasm of the oral cavity (HP:0100649)	4.24004880
12	Delusions (HP:0000746)	4.11345167
13	Abnormality of the lower motor neuron (HP:0002366)	3.98542183
14	Biliary tract neoplasm (HP:0100574)	3.95888393
15	Increased hepatocellular lipid droplets (HP:0006565)	3.81046525
16	Lipid accumulation in hepatocytes (HP:0006561)	3.78082570
17	Basal cell carcinoma (HP:0002671)	3.38832283
18	Acute encephalopathy (HP:0006846)	3.26497276
19	Aplasia/hypoplasia of the uterus (HP:0008684)	3.18456802
20	Hepatocellular necrosis (HP:0001404)	3.10220184
21	Hepatic necrosis (HP:0002605)	3.04228708
22	Hypothermia (HP:0002045)	3.01867219
23	Acute necrotizing encephalopathy (HP:0006965)	3.00670061
24	Tetraparesis (HP:0002273)	2.96869089
25	Neoplasm of striated muscle (HP:0009728)	2.90509445
26	Neoplasm of the small intestine (HP:0100833)	2.86419365
27	Type II lissencephaly (HP:0007260)	2.82099224
28	Mitochondrial inheritance (HP:0001427)	2.81555266
29	Hypoplasia of the uterus (HP:0000013)	2.81554594
30	Progressive macrocephaly (HP:0004481)	2.78162627
31	Cerebellar dysplasia (HP:0007033)	2.70526928
32	Abnormality of the salivary glands (HP:0010286)	2.70504280
33	Renal Fanconi syndrome (HP:0001994)	2.62411299
34	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.61459605
35	Primitive neuroectodermal tumor (HP:0030065)	2.59253932
36	Neuroblastic tumors (HP:0004376)	2.59253932
37	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	2.59253932
38	Neuroblastoma (HP:0003006)	2.59253932
39	Abnormal biliary tract morphology (HP:0012440)	2.56606719
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55214706
41	Neoplasm of the rectum (HP:0100743)	2.52037469
42	Respiratory difficulties (HP:0002880)	2.50523446
43	Abnormal sex determination (HP:0012244)	2.47384819
44	Sex reversal (HP:0012245)	2.47384819
45	Cerebral hypomyelination (HP:0006808)	2.47166642
46	Increased intramyocellular lipid droplets (HP:0012240)	2.45612884
47	Amaurosis fugax (HP:0100576)	2.41398293
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40105363
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33634448
50	Increased CSF lactate (HP:0002490)	2.31173165
51	Increased muscle lipid content (HP:0009058)	2.27753678
52	Polyphagia (HP:0002591)	2.27523978
53	Febrile seizures (HP:0002373)	2.15925286
54	Abnormality of lateral ventricle (HP:0030047)	2.10937395
55	Abnormality of renal resorption (HP:0011038)	2.09093718
56	Benign neoplasm of the central nervous system (HP:0100835)	2.08543157
57	Molar tooth sign on MRI (HP:0002419)	2.06387685
58	Abnormality of midbrain morphology (HP:0002418)	2.06387685
59	Exertional dyspnea (HP:0002875)	2.06101682
60	CNS demyelination (HP:0007305)	2.06038253
61	Fibroma (HP:0010614)	2.03279782
62	Cutaneous melanoma (HP:0012056)	2.02953607
63	Cerebral edema (HP:0002181)	2.00662524
64	Supranuclear gaze palsy (HP:0000605)	1.97518400
65	Hyperphosphaturia (HP:0003109)	1.95948707
66	Ketoacidosis (HP:0001993)	1.94403152
67	Hemiparesis (HP:0001269)	1.94235026
68	Male pseudohermaphroditism (HP:0000037)	1.92978325
69	Concave nail (HP:0001598)	1.92090005
70	Fibrous tissue neoplasm (HP:0012316)	1.90967415
71	Neuroectodermal neoplasm (HP:0030061)	1.90357821
72	Neuroepithelial neoplasm (HP:0030063)	1.90357821
73	Nervous tissue neoplasm (HP:0030060)	1.90357821
74	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.87769787
75	Anteriorly placed anus (HP:0001545)	1.86446408
76	Abnormality of the labia minora (HP:0012880)	1.86222347
77	Hyperglycemia (HP:0003074)	1.82864735
78	Freckling (HP:0001480)	1.79718092
79	Epileptic encephalopathy (HP:0200134)	1.79234736
80	Hyperglycinuria (HP:0003108)	1.78234033
81	Poor head control (HP:0002421)	1.75051543
82	Respiratory failure (HP:0002878)	1.73486830
83	Malignant neoplasm of the central nervous system (HP:0100836)	1.72774315
84	Abnormality of fatty-acid metabolism (HP:0004359)	1.72276822
85	Failure to thrive in infancy (HP:0001531)	1.69388974
86	Ketosis (HP:0001946)	1.69161722
87	CNS hypomyelination (HP:0003429)	1.67906281
88	Unilateral renal agenesis (HP:0000122)	1.67836690
89	Tented upper lip vermilion (HP:0010804)	1.67834866
90	Congenital stationary night blindness (HP:0007642)	1.67327747
91	Neoplasm of the liver (HP:0002896)	1.65413077
92	Intestinal polyposis (HP:0200008)	1.65104227
93	Hyperthyroidism (HP:0000836)	1.64635738
94	Progressive inability to walk (HP:0002505)	1.63211091
95	Neoplasm of the respiratory system (HP:0100606)	1.62843407
96	Microretrognathia (HP:0000308)	1.61116139
97	Abnormal neuron morphology (HP:0012757)	1.59597247
98	Abnormality of the motor neurons (HP:0002450)	1.59597247
99	Morphological abnormality of the inner ear (HP:0011390)	1.59244428
100	Lethargy (HP:0001254)	1.55894664

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	4.88998031
2	MAP4K2	4.44467395
3	PAK4	4.33963189
4	PRKD3	3.86526206
5	BCKDK	2.79622230
6	FRK	2.67645878
7	PDK2	2.60339839
8	BRSK2	2.47446993
9	PAK3	2.30388525
10	TNK2	2.29385435
11	MAPKAPK3	2.18340699
12	BRSK1	2.07971379
13	PRKD2	1.98536635
14	FGFR2	1.89610592
15	MAPK13	1.89140548
16	TAOK3	1.71972415
17	ERBB3	1.63242155
18	TAOK1	1.62401231
19	NLK	1.49309319
20	DAPK2	1.42269676
21	PBK	1.42043909
22	EIF2AK3	1.40520448
23	PRKCH	1.37709816
24	MINK1	1.31226251
25	DAPK1	1.25768249
26	ADRBK2	1.25398953
27	PIM2	1.24591111
28	TLK1	1.16767699
29	CSNK1G3	1.15538695
30	CSNK1G1	1.13866417
31	CSNK1D	1.13662205
32	MARK1	1.12385405
33	PINK1	1.03666551
34	PRKCI	1.00927628
35	PTK6	0.99501665
36	STK11	0.99022315
37	SIK3	0.96097101
38	ACVR1B	0.95873883
39	MAP3K2	0.93759887
40	MAP3K4	0.90409648
41	MAP2K7	0.89982713
42	PRKCE	0.88594336
43	BCR	0.88581381
44	CDK3	0.87689124
45	CSNK1A1L	0.87651248
46	KIT	0.86375808
47	DYRK1B	0.85718024
48	PLK2	0.84857476
49	DYRK2	0.83035019
50	MAP2K6	0.80041074
51	TRIM28	0.79553063
52	CASK	0.79518929
53	UHMK1	0.77353169
54	SYK	0.75304891
55	GSK3A	0.74326115
56	RIPK4	0.74178316
57	CSNK1G2	0.72861070
58	PASK	0.72654070
59	PRKCG	0.71213103
60	NME1	0.70327276
61	PHKG2	0.69077731
62	PHKG1	0.69077731
63	TNIK	0.68514147
64	WNK4	0.62547845
65	ARAF	0.59605767
66	EIF2AK2	0.58368973
67	INSRR	0.58344308
68	TSSK6	0.49536750
69	NTRK2	0.49224984
70	MAP2K4	0.48360724
71	GRK1	0.48147085
72	BMPR2	0.45897877
73	MAP3K6	0.45375959
74	PRKCZ	0.44036285
75	ERBB2	0.43893476
76	PIK3CG	0.43394892
77	DYRK1A	0.42375354
78	FLT3	0.41336015
79	FER	0.39833087
80	NUAK1	0.38029118
81	GRK6	0.37047878
82	MARK3	0.36539078
83	RPS6KB1	0.35983493
84	ATM	0.35710387
85	PKN1	0.34995937
86	MAPK4	0.34513204
87	ADRBK1	0.33384711
88	RAF1	0.32796274
89	CSNK1A1	0.32694364
90	CSNK2A2	0.31772620
91	PRKCA	0.29979318
92	STK38	0.29390413
93	PRKAA1	0.29273748
94	IRAK1	0.28252894
95	CSNK1E	0.27244455
96	MAPK12	0.26612190
97	PRKD1	0.25779505
98	CDK2	0.24750624
99	ILK	0.24295919
100	PNCK	0.23659292

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.56687131
2	Mismatch repair_Homo sapiens_hsa03430	3.96323791
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.70020641
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.35194879
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.97409602
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78517560
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.74441248
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.46011740
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.35067486
10	Parkinsons disease_Homo sapiens_hsa05012	2.25749456
11	Butanoate metabolism_Homo sapiens_hsa00650	2.06464247
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03103316
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.87431772
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.86278741
15	Nicotine addiction_Homo sapiens_hsa05033	1.79916404
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.63114831
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.62800718
18	Regulation of autophagy_Homo sapiens_hsa04140	1.58630163
19	Alzheimers disease_Homo sapiens_hsa05010	1.56328000
20	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.56275084
21	Peroxisome_Homo sapiens_hsa04146	1.53530203
22	Fatty acid elongation_Homo sapiens_hsa00062	1.53178907
23	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.50850199
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.45667744
25	Propanoate metabolism_Homo sapiens_hsa00640	1.45048453
26	Huntingtons disease_Homo sapiens_hsa05016	1.44965030
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42182117
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40738739
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37487289
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.34839560
31	RNA polymerase_Homo sapiens_hsa03020	1.28530819
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.17202065
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.10322699
34	Olfactory transduction_Homo sapiens_hsa04740	1.08447957
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08042903
36	Amphetamine addiction_Homo sapiens_hsa05031	1.07433872
37	Taste transduction_Homo sapiens_hsa04742	1.06419689
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.05845598
39	Arginine biosynthesis_Homo sapiens_hsa00220	1.03995446
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02428323
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99370255
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.97827395
43	Insulin secretion_Homo sapiens_hsa04911	0.90727352
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.90204322
45	DNA replication_Homo sapiens_hsa03030	0.89651247
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88841913
47	One carbon pool by folate_Homo sapiens_hsa00670	0.88462923
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79531548
49	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76728378
50	Sulfur relay system_Homo sapiens_hsa04122	0.76603881
51	Colorectal cancer_Homo sapiens_hsa05210	0.73208807
52	Proteasome_Homo sapiens_hsa03050	0.72438745
53	Metabolic pathways_Homo sapiens_hsa01100	0.72426671
54	Protein export_Homo sapiens_hsa03060	0.71327674
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.70677407
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67267349
57	Purine metabolism_Homo sapiens_hsa00230	0.67093947
58	Morphine addiction_Homo sapiens_hsa05032	0.67091317
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64996591
60	GABAergic synapse_Homo sapiens_hsa04727	0.63810900
61	Fatty acid degradation_Homo sapiens_hsa00071	0.58591405
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58046075
63	Cocaine addiction_Homo sapiens_hsa05030	0.56653674
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55366867
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52863961
66	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51871795
67	Phototransduction_Homo sapiens_hsa04744	0.51503091
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.51063057
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50051948
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49912215
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47777992
72	Prolactin signaling pathway_Homo sapiens_hsa04917	0.46826600
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.46349062
74	Folate biosynthesis_Homo sapiens_hsa00790	0.44268218
75	ErbB signaling pathway_Homo sapiens_hsa04012	0.43650581
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41012255
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.40361465
78	Circadian rhythm_Homo sapiens_hsa04710	0.39548960
79	Basal transcription factors_Homo sapiens_hsa03022	0.38676987
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38124462
81	Homologous recombination_Homo sapiens_hsa03440	0.37394054
82	Carbon metabolism_Homo sapiens_hsa01200	0.37308410
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36396325
84	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35068650
85	RNA transport_Homo sapiens_hsa03013	0.33270504
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.33033420
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31403858
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.30372311
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.29893003
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29836579
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.27803857
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.27611294
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.26589821
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25865160
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.24884283
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24792326
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.24155790
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23887827
99	Circadian entrainment_Homo sapiens_hsa04713	0.23817435
100	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22753847

RPL9P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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