ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kinetochore assembly (GO:0051382)	6.16830525
2	kinetochore organization (GO:0051383)	5.74474492
3	regulation of meiosis I (GO:0060631)	5.22962715
4	melanin biosynthetic process (GO:0042438)	4.99671476
5	secondary metabolite biosynthetic process (GO:0044550)	4.71023289
6	melanin metabolic process (GO:0006582)	4.56421478
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.49774366
8	resolution of meiotic recombination intermediates (GO:0000712)	4.43119355
9	microtubule depolymerization (GO:0007019)	4.42965609
10	replication fork processing (GO:0031297)	4.37900973
11	rRNA methylation (GO:0031167)	4.31566585
12	response to pheromone (GO:0019236)	4.21960197
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.05217754
14	NADH dehydrogenase complex assembly (GO:0010257)	4.05217754
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.05217754
16	protein complex biogenesis (GO:0070271)	4.01229775
17	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.93387598
18	auditory receptor cell stereocilium organization (GO:0060088)	3.91828854
19	rRNA modification (GO:0000154)	3.74461630
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.68898727
21	prenylation (GO:0097354)	3.55494675
22	protein prenylation (GO:0018342)	3.55494675
23	DNA deamination (GO:0045006)	3.54927410
24	synapsis (GO:0007129)	3.51900430
25	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.49928781
26	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.47457924
27	righting reflex (GO:0060013)	3.36277341
28	keratinocyte development (GO:0003334)	3.27252118
29	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.26034055
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.16905280
31	organelle disassembly (GO:1903008)	3.16450832
32	histone H2A acetylation (GO:0043968)	3.15699585
33	male meiosis (GO:0007140)	3.11283156
34	DNA double-strand break processing (GO:0000729)	3.11266948
35	cornea development in camera-type eye (GO:0061303)	3.07367887
36	recombinational repair (GO:0000725)	3.04100621
37	nonmotile primary cilium assembly (GO:0035058)	3.00613724
38	double-strand break repair via homologous recombination (GO:0000724)	2.99749474
39	positive regulation of meiosis (GO:0045836)	2.99200391
40	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.98743714
41	inner ear receptor stereocilium organization (GO:0060122)	2.97252462
42	melanocyte differentiation (GO:0030318)	2.96944926
43	pigment cell differentiation (GO:0050931)	2.96516047
44	ventricular system development (GO:0021591)	2.96311365
45	behavioral response to ethanol (GO:0048149)	2.93238920
46	meiotic chromosome segregation (GO:0045132)	2.92720648
47	startle response (GO:0001964)	2.91808026
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.90374204
49	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.90374204
50	mitochondrial genome maintenance (GO:0000002)	2.89976444
51	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.89439889
52	mismatch repair (GO:0006298)	2.87692025
53	reciprocal DNA recombination (GO:0035825)	2.86870980
54	reciprocal meiotic recombination (GO:0007131)	2.86870980
55	respiratory chain complex IV assembly (GO:0008535)	2.83879173
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83425843
57	cytochrome complex assembly (GO:0017004)	2.82865939
58	positive regulation of cell fate commitment (GO:0010455)	2.81497953
59	ribonucleoprotein complex disassembly (GO:0032988)	2.81330677
60	DNA methylation involved in gamete generation (GO:0043046)	2.80941817
61	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.80197540
62	mRNA cleavage (GO:0006379)	2.78466553
63	positive regulation of meiotic cell cycle (GO:0051446)	2.77552808
64	negative regulation of DNA recombination (GO:0045910)	2.77288109
65	proteasome assembly (GO:0043248)	2.75593649
66	protein neddylation (GO:0045116)	2.73214443
67	centriole replication (GO:0007099)	2.70755280
68	electron transport chain (GO:0022900)	2.70432603
69	piRNA metabolic process (GO:0034587)	2.70054175
70	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69480729
71	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.69175081
72	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.69175081
73	regulation of translation, ncRNA-mediated (GO:0045974)	2.69175081
74	kidney morphogenesis (GO:0060993)	2.68126412
75	respiratory electron transport chain (GO:0022904)	2.67869371
76	reflex (GO:0060004)	2.65890320
77	nucleoside diphosphate catabolic process (GO:0009134)	2.65390440
78	behavioral response to nicotine (GO:0035095)	2.63551623
79	histone H3-K4 trimethylation (GO:0080182)	2.61143295
80	negative regulation of dendrite development (GO:2000171)	2.59745613
81	lactate metabolic process (GO:0006089)	2.58678621
82	negative regulation of telomere maintenance (GO:0032205)	2.57496620
83	phosphorelay signal transduction system (GO:0000160)	2.56902588
84	neuroepithelial cell differentiation (GO:0060563)	2.54216539
85	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.54176924
86	microtubule polymerization or depolymerization (GO:0031109)	2.53990706
87	ketone body metabolic process (GO:1902224)	2.51823637
88	positive regulation of interleukin-17 production (GO:0032740)	2.49788930
89	protein localization to cilium (GO:0061512)	2.49490167
90	positive regulation of prostaglandin secretion (GO:0032308)	2.49210408
91	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.48097546
92	water-soluble vitamin biosynthetic process (GO:0042364)	2.44870204
93	regulation of sarcomere organization (GO:0060297)	2.44618232
94	spliceosomal complex assembly (GO:0000245)	2.43351440
95	neural tube formation (GO:0001841)	2.43286080
96	myelin assembly (GO:0032288)	2.42371580
97	DNA damage response, detection of DNA damage (GO:0042769)	2.41580401
98	negative regulation of dendrite morphogenesis (GO:0050774)	2.41522255
99	pseudouridine synthesis (GO:0001522)	2.41482039
100	mannosylation (GO:0097502)	2.41350793

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.08955407
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.24743443
3	VDR_22108803_ChIP-Seq_LS180_Human	3.09804407
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.09125062
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93451214
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.92702853
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80778366
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.76352732
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.68836425
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63695799
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.60743054
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.47357248
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.34927635
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.32648407
15	EWS_26573619_Chip-Seq_HEK293_Human	2.32416047
16	FUS_26573619_Chip-Seq_HEK293_Human	2.32289409
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11839694
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09135068
19	P300_19829295_ChIP-Seq_ESCs_Human	2.02980350
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.01004248
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.90925189
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.86228847
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83426816
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82838432
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82294901
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81843120
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.78552063
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75066653
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70349018
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.70137253
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.69047229
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68734181
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68521111
34	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.67428997
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65077714
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.64992680
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64528116
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63562495
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59055230
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.59055230
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48622686
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48464532
43	TCF4_23295773_ChIP-Seq_U87_Human	1.43792376
44	AR_25329375_ChIP-Seq_VCAP_Human	1.41762236
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41517388
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38772799
47	STAT3_23295773_ChIP-Seq_U87_Human	1.38691576
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37724798
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.37389815
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37025002
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36824366
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35226924
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33911370
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32430211
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30083928
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30083928
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28740068
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28228609
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28228609
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23401092
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23098730
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22789346
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.22779993
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22394204
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21235438
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17381385
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16579593
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.16541690
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16303623
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12678681
71	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.12522146
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.12330005
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11209606
74	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.09791050
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09228061
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09184577
77	TP53_22573176_ChIP-Seq_HFKS_Human	1.09014049
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.08540850
79	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07081529
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05935076
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05238442
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.04735888
83	P300_18555785_Chip-Seq_ESCs_Mouse	1.04651973
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04210708
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04188496
86	JUN_21703547_ChIP-Seq_K562_Human	1.04181499
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03599250
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03265640
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03191106
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02771785
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01857807
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00548357
93	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00010287
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99772855
95	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98955259
96	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98387416
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.98342747
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97237499
99	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.96947644
100	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.96776283

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	6.33801346
2	MP0005171_absent_coat_pigmentation	3.69557351
3	MP0005408_hypopigmentation	3.56421691
4	MP0003136_yellow_coat_color	3.06873150
5	MP0002938_white_spotting	2.96686334
6	MP0006292_abnormal_olfactory_placode	2.90033408
7	MP0000015_abnormal_ear_pigmentation	2.74623243
8	MP0002736_abnormal_nociception_after	2.61550673
9	MP0005075_abnormal_melanosome_morpholog	2.53446312
10	MP0003195_calcinosis	2.44616420
11	MP0008877_abnormal_DNA_methylation	2.38837269
12	MP0001968_abnormal_touch/_nociception	2.36789415
13	MP0002102_abnormal_ear_morphology	2.36432534
14	MP0002095_abnormal_skin_pigmentation	2.21427976
15	MP0008058_abnormal_DNA_repair	2.05858751
16	MP0002837_dystrophic_cardiac_calcinosis	1.97293399
17	MP0008875_abnormal_xenobiotic_pharmacok	1.95390395
18	MP0000371_diluted_coat_color	1.91691722
19	MP0010094_abnormal_chromosome_stability	1.83701693
20	MP0008057_abnormal_DNA_replication	1.79892922
21	MP0000569_abnormal_digit_pigmentation	1.78976518
22	MP0001986_abnormal_taste_sensitivity	1.75573465
23	MP0005174_abnormal_tail_pigmentation	1.72850746
24	MP0005646_abnormal_pituitary_gland	1.66818899
25	MP0002822_catalepsy	1.64467160
26	MP0003646_muscle_fatigue	1.63364419
27	MP0004147_increased_porphyrin_level	1.62103776
28	MP0005551_abnormal_eye_electrophysiolog	1.61459677
29	MP0006036_abnormal_mitochondrial_physio	1.56453995
30	MP0001486_abnormal_startle_reflex	1.55777820
31	MP0000631_abnormal_neuroendocrine_gland	1.52131896
32	MP0009046_muscle_twitch	1.43972449
33	MP0008872_abnormal_physiological_respon	1.43470904
34	MP0003111_abnormal_nucleus_morphology	1.39492847
35	MP0001324_abnormal_eye_pigmentation	1.37935395
36	MP0003806_abnormal_nucleotide_metabolis	1.37077303
37	MP0005248_abnormal_Harderian_gland	1.34472738
38	MP0002139_abnormal_hepatobiliary_system	1.32585183
39	MP0004885_abnormal_endolymph	1.28290250
40	MP0005253_abnormal_eye_physiology	1.27596929
41	MP0004043_abnormal_pH_regulation	1.26736189
42	MP0008995_early_reproductive_senescence	1.23462288
43	MP0002163_abnormal_gland_morphology	1.22954703
44	MP0006072_abnormal_retinal_apoptosis	1.19539987
45	MP0008789_abnormal_olfactory_epithelium	1.16534934
46	MP0003786_premature_aging	1.16361825
47	MP0005377_hearing/vestibular/ear_phenot	1.14468298
48	MP0003878_abnormal_ear_physiology	1.14468298
49	MP0004215_abnormal_myocardial_fiber	1.13838342
50	MP0002638_abnormal_pupillary_reflex	1.13771739
51	MP0003718_maternal_effect	1.13343287
52	MP0003787_abnormal_imprinting	1.12812695
53	MP0004742_abnormal_vestibular_system	1.11665975
54	MP0004381_abnormal_hair_follicle	1.06189493
55	MP0002075_abnormal_coat/hair_pigmentati	1.04750595
56	MP0009745_abnormal_behavioral_response	1.04371172
57	MP0001188_hyperpigmentation	1.03907921
58	MP0005386_behavior/neurological_phenoty	1.03661630
59	MP0004924_abnormal_behavior	1.03661630
60	MP0002909_abnormal_adrenal_gland	1.03143424
61	MP0002272_abnormal_nervous_system	1.00225813
62	MP0001984_abnormal_olfaction	0.93743385
63	MP0005084_abnormal_gallbladder_morpholo	0.93722162
64	MP0001929_abnormal_gametogenesis	0.93539119
65	MP0009697_abnormal_copulation	0.92259336
66	MP0002735_abnormal_chemical_nociception	0.91646514
67	MP0002210_abnormal_sex_determination	0.91417669
68	MP0000516_abnormal_urinary_system	0.90480594
69	MP0005367_renal/urinary_system_phenotyp	0.90480594
70	MP0001186_pigmentation_phenotype	0.89894862
71	MP0002090_abnormal_vision	0.88790837
72	MP0003567_abnormal_fetal_cardiomyocyte	0.86755631
73	MP0001485_abnormal_pinna_reflex	0.86741206
74	MP0004142_abnormal_muscle_tone	0.85076902
75	MP0003880_abnormal_central_pattern	0.84230338
76	MP0003698_abnormal_male_reproductive	0.83331130
77	MP0003137_abnormal_impulse_conducting	0.81255597
78	MP0002229_neurodegeneration	0.78667031
79	MP0002733_abnormal_thermal_nociception	0.77106534
80	MP0002734_abnormal_mechanical_nocicepti	0.75211774
81	MP0006035_abnormal_mitochondrial_morpho	0.74884969
82	MP0002233_abnormal_nose_morphology	0.74400249
83	MP0001145_abnormal_male_reproductive	0.74349866
84	MP0005645_abnormal_hypothalamus_physiol	0.74246487
85	MP0005379_endocrine/exocrine_gland_phen	0.73186085
86	MP0001529_abnormal_vocalization	0.72388725
87	MP0002064_seizures	0.71989911
88	MP0002234_abnormal_pharynx_morphology	0.71929791
89	MP0005195_abnormal_posterior_eye	0.70708602
90	MP0003938_abnormal_ear_development	0.70191792
91	MP0000427_abnormal_hair_cycle	0.69023224
92	MP0000653_abnormal_sex_gland	0.68670924
93	MP0002067_abnormal_sensory_capabilities	0.68087706
94	MP0001970_abnormal_pain_threshold	0.68020646
95	MP0003943_abnormal_hepatobiliary_system	0.67951230
96	MP0000026_abnormal_inner_ear	0.67193146
97	MP0008775_abnormal_heart_ventricle	0.67128984
98	MP0005451_abnormal_body_composition	0.65864818
99	MP0003635_abnormal_synaptic_transmissio	0.65719978
100	MP0008873_increased_physiological_sensi	0.64550781

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.39105362
2	Acute necrotizing encephalopathy (HP:0006965)	3.87263377
3	Chromsome breakage (HP:0040012)	3.60861583
4	Progressive macrocephaly (HP:0004481)	3.54132469
5	Acute encephalopathy (HP:0006846)	3.43503055
6	Congenital sensorineural hearing impairment (HP:0008527)	3.33069885
7	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.29966126
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23469991
9	Abnormality of the labia minora (HP:0012880)	3.13489257
10	Hypoplasia of the fovea (HP:0007750)	3.09579409
11	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.09579409
12	Abnormality of midbrain morphology (HP:0002418)	3.08982050
13	Molar tooth sign on MRI (HP:0002419)	3.08982050
14	Pancreatic fibrosis (HP:0100732)	3.08449320
15	Mitochondrial inheritance (HP:0001427)	2.92110991
16	Increased CSF lactate (HP:0002490)	2.89338441
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.82122456
18	Pancreatic cysts (HP:0001737)	2.79049463
19	Type II lissencephaly (HP:0007260)	2.71980078
20	Absent speech (HP:0001344)	2.68076198
21	Methylmalonic acidemia (HP:0002912)	2.60024576
22	Nephronophthisis (HP:0000090)	2.59960724
23	Meckel diverticulum (HP:0002245)	2.58310096
24	Aplasia/Hypoplasia of the macula (HP:0008059)	2.55999810
25	Abnormality of the fovea (HP:0000493)	2.55860992
26	Abnormality of chromosome stability (HP:0003220)	2.51288431
27	Abnormality of the ileum (HP:0001549)	2.47232963
28	Febrile seizures (HP:0002373)	2.47040919
29	Hepatocellular necrosis (HP:0001404)	2.45894965
30	Patchy hypopigmentation of hair (HP:0011365)	2.41896104
31	Abnormality of the preputium (HP:0100587)	2.41701147
32	Intestinal atresia (HP:0011100)	2.41501217
33	Gaze-evoked nystagmus (HP:0000640)	2.39840433
34	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.39554266
35	Blue irides (HP:0000635)	2.34386069
36	Cystic liver disease (HP:0006706)	2.31637565
37	Hepatic necrosis (HP:0002605)	2.30489493
38	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.29867818
39	Progressive cerebellar ataxia (HP:0002073)	2.29836003
40	Adrenal hypoplasia (HP:0000835)	2.29789920
41	Facial hemangioma (HP:0000329)	2.28500352
42	Hypoplastic labia majora (HP:0000059)	2.27802105
43	Abnormality of the renal medulla (HP:0100957)	2.24369082
44	True hermaphroditism (HP:0010459)	2.24129066
45	3-Methylglutaconic aciduria (HP:0003535)	2.23603303
46	Increased serum pyruvate (HP:0003542)	2.22638670
47	White forelock (HP:0002211)	2.21863596
48	Optic disc pallor (HP:0000543)	2.18922705
49	Abnormality of lateral ventricle (HP:0030047)	2.17905776
50	Long clavicles (HP:0000890)	2.16886726
51	Chronic hepatic failure (HP:0100626)	2.16194523
52	Clubbing of toes (HP:0100760)	2.13782443
53	Abnormality of the renal cortex (HP:0011035)	2.13529517
54	Renal hypoplasia (HP:0000089)	2.11822628
55	Postaxial foot polydactyly (HP:0001830)	2.11634101
56	Abnormal lung lobation (HP:0002101)	2.09435046
57	Tubulointerstitial nephritis (HP:0001970)	2.08356234
58	Median cleft lip (HP:0000161)	2.07623960
59	Duodenal stenosis (HP:0100867)	2.07242961
60	Small intestinal stenosis (HP:0012848)	2.07242961
61	Abnormality of the labia majora (HP:0012881)	2.07168969
62	Cerebral edema (HP:0002181)	2.06261343
63	Neoplasm of the adrenal cortex (HP:0100641)	2.00563512
64	Astigmatism (HP:0000483)	2.00434599
65	Cerebellar dysplasia (HP:0007033)	2.00160168
66	Abnormality of the duodenum (HP:0002246)	1.97604591
67	Congenital stationary night blindness (HP:0007642)	1.97603626
68	Sloping forehead (HP:0000340)	1.96437762
69	Methylmalonic aciduria (HP:0012120)	1.94555324
70	Generalized hypopigmentation of hair (HP:0011358)	1.91442896
71	Abnormality of alanine metabolism (HP:0010916)	1.90937500
72	Hyperalaninemia (HP:0003348)	1.90937500
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90937500
74	Dandy-Walker malformation (HP:0001305)	1.89923388
75	Submucous cleft hard palate (HP:0000176)	1.89921723
76	Ectopic kidney (HP:0000086)	1.86288123
77	Erythroderma (HP:0001019)	1.85013177
78	Abnormal drinking behavior (HP:0030082)	1.84774114
79	Polydipsia (HP:0001959)	1.84774114
80	Aqueductal stenosis (HP:0002410)	1.84261533
81	Leukodystrophy (HP:0002415)	1.83551448
82	Lissencephaly (HP:0001339)	1.83437112
83	Tubular atrophy (HP:0000092)	1.83095982
84	X-linked dominant inheritance (HP:0001423)	1.82217682
85	Megalencephaly (HP:0001355)	1.79912011
86	Anencephaly (HP:0002323)	1.78486672
87	Gastrointestinal atresia (HP:0002589)	1.77906472
88	Abnormality of glycolysis (HP:0004366)	1.76588823
89	Severe muscular hypotonia (HP:0006829)	1.74180743
90	Colon cancer (HP:0003003)	1.74177227
91	Tented upper lip vermilion (HP:0010804)	1.73718535
92	Hypothermia (HP:0002045)	1.72595988
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72266992
94	Hemivertebrae (HP:0002937)	1.70630548
95	Retinal dysplasia (HP:0007973)	1.70615437
96	Medial flaring of the eyebrow (HP:0010747)	1.69927688
97	Shawl scrotum (HP:0000049)	1.69165793
98	Cupped ear (HP:0000378)	1.68420829
99	Duplicated collecting system (HP:0000081)	1.67154562
100	Rib fusion (HP:0000902)	1.66862058

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28339986
2	WEE1	2.83865067
3	WNK3	2.80919784
4	MAPK13	2.63994472
5	PNCK	2.61273159
6	NUAK1	2.41551783
7	PDK2	2.29527644
8	BRSK2	2.01101064
9	BMPR2	1.94238624
10	PHKG1	1.79881825
11	PHKG2	1.79881825
12	ZAK	1.78480370
13	CAMK1G	1.72568939
14	STK39	1.70345097
15	TAF1	1.69684349
16	PLK4	1.68532513
17	MKNK2	1.64600784
18	MAP4K2	1.63889916
19	CASK	1.60441660
20	PLK3	1.60329973
21	MARK1	1.59473059
22	EIF2AK1	1.58346220
23	EIF2AK3	1.54314875
24	MST4	1.50393262
25	GRK1	1.43275329
26	OXSR1	1.40841832
27	CLK1	1.39596843
28	TRIM28	1.39172624
29	SIK2	1.33944004
30	MAP3K4	1.33751822
31	NEK2	1.32437193
32	PAK3	1.29219745
33	RIPK4	1.29149498
34	CCNB1	1.26056782
35	BMPR1B	1.25798874
36	PLK2	1.21275909
37	ERBB3	1.18220766
38	ADRBK2	1.15862399
39	AKT3	1.09824259
40	PBK	1.07303633
41	ACVR1B	1.05404837
42	PLK1	1.04347777
43	PINK1	0.98220391
44	PTK2B	0.97885166
45	CSNK1G2	0.95743394
46	CAMK1D	0.95680227
47	NME1	0.95253902
48	VRK1	0.94884559
49	MKNK1	0.93885223
50	TTK	0.93833168
51	VRK2	0.93673215
52	PIK3CG	0.92163127
53	CSNK1G1	0.89943587
54	MARK3	0.89725970
55	BCR	0.86765987
56	WNK4	0.86252472
57	CSNK1G3	0.82923353
58	INSRR	0.81557447
59	ATR	0.80602372
60	IRAK1	0.80208069
61	PKN1	0.72240603
62	CSNK1A1L	0.71985067
63	TEC	0.70565229
64	BUB1	0.66905543
65	PRKCE	0.65419166
66	CAMK2D	0.64131177
67	BRSK1	0.63173015
68	TNIK	0.59763803
69	NTRK2	0.59064027
70	GRK5	0.58595286
71	ADRBK1	0.58093896
72	ATM	0.56761932
73	SGK2	0.54261460
74	ILK	0.53564251
75	MAP2K7	0.51833327
76	CDK3	0.51134825
77	SRPK1	0.50165141
78	CAMK2A	0.48991940
79	TXK	0.48990297
80	TSSK6	0.48904899
81	NEK1	0.48598458
82	CHEK2	0.48434986
83	CAMK2B	0.48309295
84	TAOK3	0.47659330
85	EGFR	0.46412382
86	PRKCG	0.45261789
87	FGFR2	0.45048198
88	ERBB2	0.44927395
89	CSNK1D	0.44814944
90	STK38L	0.43376985
91	EPHA4	0.43342722
92	LATS1	0.42817706
93	DAPK2	0.42640803
94	MINK1	0.41696745
95	SIK3	0.40521882
96	PRKACA	0.40293641
97	UHMK1	0.40090824
98	FER	0.39663955
99	CSNK1E	0.39066628
100	WNK1	0.38590959

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.65247308
2	Homologous recombination_Homo sapiens_hsa03440	3.47500882
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.33881243
4	Mismatch repair_Homo sapiens_hsa03430	3.27312471
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.85622137
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.46241988
7	Proteasome_Homo sapiens_hsa03050	2.42237906
8	Basal transcription factors_Homo sapiens_hsa03022	2.22357575
9	Parkinsons disease_Homo sapiens_hsa05012	2.20418162
10	RNA polymerase_Homo sapiens_hsa03020	2.12886407
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.05892790
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.01198785
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.89598631
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79571431
15	Huntingtons disease_Homo sapiens_hsa05016	1.77630849
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75026044
17	RNA degradation_Homo sapiens_hsa03018	1.69369565
18	Propanoate metabolism_Homo sapiens_hsa00640	1.69016986
19	Butanoate metabolism_Homo sapiens_hsa00650	1.58715276
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55116727
21	Asthma_Homo sapiens_hsa05310	1.54002840
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51966721
23	Alzheimers disease_Homo sapiens_hsa05010	1.50040313
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.48335199
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48197985
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45152187
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41832904
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37392215
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30573589
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.26064072
31	Caffeine metabolism_Homo sapiens_hsa00232	1.25356172
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20585977
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20336897
34	Olfactory transduction_Homo sapiens_hsa04740	1.18252625
35	Fatty acid elongation_Homo sapiens_hsa00062	1.15094048
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.08593190
37	Purine metabolism_Homo sapiens_hsa00230	1.04501201
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00872062
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.97096188
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.96840774
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96556011
42	Phototransduction_Homo sapiens_hsa04744	0.96436897
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93676758
44	Nicotine addiction_Homo sapiens_hsa05033	0.91462774
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89701356
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.89377297
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89252093
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88755679
49	Allograft rejection_Homo sapiens_hsa05330	0.87964060
50	Fatty acid degradation_Homo sapiens_hsa00071	0.87210774
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87123607
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84311069
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83598777
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83327747
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.81186239
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80799694
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.78910321
58	Peroxisome_Homo sapiens_hsa04146	0.77838962
59	DNA replication_Homo sapiens_hsa03030	0.77361300
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77213649
61	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76460828
62	One carbon pool by folate_Homo sapiens_hsa00670	0.72087217
63	RNA transport_Homo sapiens_hsa03013	0.70957375
64	Spliceosome_Homo sapiens_hsa03040	0.69122621
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68941621
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65823595
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.65777922
68	ABC transporters_Homo sapiens_hsa02010	0.65508975
69	Cell cycle_Homo sapiens_hsa04110	0.64393406
70	Metabolic pathways_Homo sapiens_hsa01100	0.61218428
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59552807
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59262956
73	Oocyte meiosis_Homo sapiens_hsa04114	0.59181085
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.58629842
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57840445
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54390200
77	p53 signaling pathway_Homo sapiens_hsa04115	0.52432157
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51161452
79	Retinol metabolism_Homo sapiens_hsa00830	0.49715781
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.49622307
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48929729
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47074087
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46335729
84	Glutathione metabolism_Homo sapiens_hsa00480	0.44010590
85	Circadian rhythm_Homo sapiens_hsa04710	0.43141418
86	Lysine degradation_Homo sapiens_hsa00310	0.42710225
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42092574
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41205690
89	Folate biosynthesis_Homo sapiens_hsa00790	0.40351876
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.39228074
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38240699
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38141623
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37949533
94	Base excision repair_Homo sapiens_hsa03410	0.37777667
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33719106
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33610092
97	Morphine addiction_Homo sapiens_hsa05032	0.32032806
98	African trypanosomiasis_Homo sapiens_hsa05143	0.32001157
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31234853
100	Sulfur metabolism_Homo sapiens_hsa00920	0.29236367

RPL9P30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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