RPL9P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)9.90710961
2chaperone-mediated protein transport (GO:0072321)9.76510232
3GDP-mannose metabolic process (GO:0019673)9.33054457
4nucleoside transmembrane transport (GO:1901642)7.95497406
5nucleoside transport (GO:0015858)6.41125912
6DNA deamination (GO:0045006)6.32319568
7interferon-gamma production (GO:0032609)5.65202904
8positive regulation of icosanoid secretion (GO:0032305)5.64492084
9positive regulation of fatty acid transport (GO:2000193)5.47858336
10positive regulation of prostaglandin secretion (GO:0032308)5.25922643
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.93187175
12cofactor transport (GO:0051181)4.79488478
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.68212580
14ATP synthesis coupled proton transport (GO:0015986)4.53827314
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53827314
16reproduction (GO:0000003)4.52983170
17regulation of icosanoid secretion (GO:0032303)4.51691984
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.51006345
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.51006345
20regulation of prostaglandin secretion (GO:0032306)4.46834781
21modified amino acid transport (GO:0072337)4.28929429
22peroxisome fission (GO:0016559)4.15220672
23chaperone mediated protein folding requiring cofactor (GO:0051085)4.03447401
24cytidine metabolic process (GO:0046087)4.00770410
25cytidine catabolic process (GO:0006216)4.00770410
26cytidine deamination (GO:0009972)4.00770410
27pantothenate metabolic process (GO:0015939)3.98306664
28positive regulation of defense response to virus by host (GO:0002230)3.95600781
29nucleotide-sugar biosynthetic process (GO:0009226)3.94477178
30behavioral response to nicotine (GO:0035095)3.93158801
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91923003
32cellular response to estradiol stimulus (GO:0071392)3.89779748
33regulation of mitochondrial membrane potential (GO:0051881)3.88117400
34endoderm formation (GO:0001706)3.83156018
35sulfur compound transport (GO:0072348)3.73680116
36negative regulation of cAMP-mediated signaling (GO:0043951)3.67042112
37protein deneddylation (GO:0000338)3.57115312
38positive regulation of protein kinase C signaling (GO:0090037)3.52643354
39short-chain fatty acid metabolic process (GO:0046459)3.50987537
40aerobic respiration (GO:0009060)3.49507021
41lateral ventricle development (GO:0021670)3.42427478
42translational elongation (GO:0006414)3.40043368
43coenzyme A biosynthetic process (GO:0015937)3.39633453
44water-soluble vitamin biosynthetic process (GO:0042364)3.36258376
45response to pheromone (GO:0019236)3.34148996
46regulation of receptor binding (GO:1900120)3.32346576
47positive regulation of organic acid transport (GO:0032892)3.31416285
48ribosomal small subunit assembly (GO:0000028)3.27645728
49carbohydrate derivative transport (GO:1901264)3.20174827
50aggressive behavior (GO:0002118)3.19042905
51histone H2A acetylation (GO:0043968)3.17505078
52pyrimidine ribonucleoside catabolic process (GO:0046133)3.16172559
53ribosomal large subunit biogenesis (GO:0042273)3.12650801
54viral transcription (GO:0019083)3.10344985
55translational termination (GO:0006415)3.06293371
56regulation of histone phosphorylation (GO:0033127)2.98966608
57regulation of penile erection (GO:0060405)2.86115826
58positive regulation of transcription regulatory region DNA binding (GO:2000679)2.83826821
59meiotic chromosome segregation (GO:0045132)2.81932100
60cellular component biogenesis (GO:0044085)2.77672385
61viral protein processing (GO:0019082)2.73330911
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.72780779
63regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.72780779
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70929516
65protein targeting to peroxisome (GO:0006625)2.69081058
66establishment of protein localization to peroxisome (GO:0072663)2.69081058
67protein localization to peroxisome (GO:0072662)2.69081058
68male meiosis (GO:0007140)2.69044726
69response to misfolded protein (GO:0051788)2.66207835
70ribosomal small subunit biogenesis (GO:0042274)2.65719087
71indolalkylamine metabolic process (GO:0006586)2.65696756
72cobalamin metabolic process (GO:0009235)2.65561896
73positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.63668120
74nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.63631584
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59497794
76purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.59103062
77cellular response to estrogen stimulus (GO:0071391)2.57665181
78cotranslational protein targeting to membrane (GO:0006613)2.55997882
79nucleotide-sugar metabolic process (GO:0009225)2.53748890
80protein targeting to ER (GO:0045047)2.52214016
81proteasome assembly (GO:0043248)2.51139975
82oxidative phosphorylation (GO:0006119)2.51080752
83translation (GO:0006412)2.50374670
84purine deoxyribonucleotide catabolic process (GO:0009155)2.49441011
85glucosamine-containing compound catabolic process (GO:1901072)2.49073876
86alternative mRNA splicing, via spliceosome (GO:0000380)2.48974997
87DNA catabolic process, exonucleolytic (GO:0000738)2.47908673
88adenosine metabolic process (GO:0046085)2.46397648
89sleep (GO:0030431)2.45767220
90regulation of defense response to virus by host (GO:0050691)2.44009472
91cellular response to ATP (GO:0071318)2.43195690
92dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.41843594
93parturition (GO:0007567)2.41394371
94translational initiation (GO:0006413)2.39690961
95drinking behavior (GO:0042756)2.38869737
96intracellular protein transmembrane import (GO:0044743)2.38386653
97protein localization to endoplasmic reticulum (GO:0070972)2.37894683
98ribonucleoprotein complex biogenesis (GO:0022613)2.37843260
99positive regulation of TOR signaling (GO:0032008)2.37816319
100viral life cycle (GO:0019058)2.36086626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse7.25632883
2ELF1_17652178_ChIP-ChIP_JURKAT_Human5.26346998
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.00590627
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76208606
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.33427686
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.09976792
7ZNF274_21170338_ChIP-Seq_K562_Hela2.72859232
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66986249
9ELK1_19687146_ChIP-ChIP_HELA_Human2.62139366
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58433063
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53951332
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36220418
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.23490211
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22548994
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.06261138
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05506013
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.03339756
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98134981
19IGF1R_20145208_ChIP-Seq_DFB_Human1.93558136
20VDR_22108803_ChIP-Seq_LS180_Human1.85397368
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77299637
22VDR_23849224_ChIP-Seq_CD4+_Human1.75855906
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66766697
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63527718
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60891910
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58202704
27GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.58082243
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.57752963
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.54367106
30FOXP3_21729870_ChIP-Seq_TREG_Human1.52718760
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47887309
32GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.43724347
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42687190
34AR_20517297_ChIP-Seq_VCAP_Human1.40958088
35MYC_19829295_ChIP-Seq_ESCs_Human1.34407240
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.33987443
37EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.33204679
38GATA3_26560356_Chip-Seq_TH2_Human1.33192229
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32093931
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29006618
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.27574045
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24496767
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.23433925
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.21918616
45RUNX_20019798_ChIP-Seq_JUKART_Human1.21489773
46TP53_22573176_ChIP-Seq_HFKS_Human1.21347896
47FUS_26573619_Chip-Seq_HEK293_Human1.21277610
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.20856733
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20764388
50RBPJ_21746931_ChIP-Seq_IB4_Human1.20721924
51NANOG_20526341_ChIP-Seq_ESCs_Human1.18670409
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17076167
53IRF1_19129219_ChIP-ChIP_H3396_Human1.16911698
54NCOR_22424771_ChIP-Seq_293T_Human1.16564589
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16542606
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15922079
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.14371639
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13553378
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.13347349
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11794870
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09830880
62PHF8_20622853_ChIP-Seq_HELA_Human1.09201966
63EZH2_22144423_ChIP-Seq_EOC_Human1.09016593
64CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07942702
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.07353281
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.06343669
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06343669
68MYC_18940864_ChIP-ChIP_HL60_Human1.04372686
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03793918
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03751408
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03614794
72KDM5A_27292631_Chip-Seq_BREAST_Human1.03595609
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03384769
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02166397
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01304726
76EWS_26573619_Chip-Seq_HEK293_Human1.01196806
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00651106
78TAF2_19829295_ChIP-Seq_ESCs_Human0.99472865
79ETV1_20927104_ChIP-Seq_GIST48_Human0.99380472
80E2F1_20622854_ChIP-Seq_HELA_Human0.99200166
81P300_19829295_ChIP-Seq_ESCs_Human0.98934544
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98734929
83SOX2_19829295_ChIP-Seq_ESCs_Human0.97412051
84NANOG_19829295_ChIP-Seq_ESCs_Human0.97412051
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96972830
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96451944
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96019227
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95754506
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95666778
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95448833
91RNF2_27304074_Chip-Seq_NSC_Mouse0.95108098
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94176041
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93401729
94OCT4_20526341_ChIP-Seq_ESCs_Human0.91570317
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.91390616
96NFYA_21822215_ChIP-Seq_K562_Human0.91259896
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90897867
98NFYB_21822215_ChIP-Seq_K562_Human0.89467234
99HOXB7_26014856_ChIP-Seq_BT474_Human0.88565025
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87715946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.56135680
2MP0006072_abnormal_retinal_apoptosis3.87613001
3MP0002138_abnormal_hepatobiliary_system2.70766832
4MP0004043_abnormal_pH_regulation2.69318331
5MP0005671_abnormal_response_to2.63653450
6MP0001986_abnormal_taste_sensitivity2.62273635
7MP0003646_muscle_fatigue2.51669694
8MP0009379_abnormal_foot_pigmentation2.47408433
9MP0008877_abnormal_DNA_methylation2.45208288
10MP0004147_increased_porphyrin_level2.22105912
11MP0002102_abnormal_ear_morphology2.10082248
12MP0006054_spinal_hemorrhage2.09838418
13MP0005646_abnormal_pituitary_gland2.09633092
14MP0001727_abnormal_embryo_implantation2.08706831
15MP0008872_abnormal_physiological_respon2.03595942
16MP0001968_abnormal_touch/_nociception2.00765861
17MP0002837_dystrophic_cardiac_calcinosis1.85791190
18MP0001542_abnormal_bone_strength1.82659744
19MP0005464_abnormal_platelet_physiology1.82172243
20MP0003693_abnormal_embryo_hatching1.81449002
21MP0006292_abnormal_olfactory_placode1.77755015
22MP0005387_immune_system_phenotype1.73554840
23MP0001790_abnormal_immune_system1.73554840
24MP0005084_abnormal_gallbladder_morpholo1.72526212
25MP0002148_abnormal_hypersensitivity_rea1.63105124
26MP0002736_abnormal_nociception_after1.60462905
27MP0008775_abnormal_heart_ventricle1.55997553
28MP0003195_calcinosis1.55668112
29MP0000685_abnormal_immune_system1.51204189
30MP0005167_abnormal_blood-brain_barrier1.48720849
31MP0006276_abnormal_autonomic_nervous1.48626263
32MP0001835_abnormal_antigen_presentation1.47493094
33MP0009764_decreased_sensitivity_to1.46003537
34MP0006035_abnormal_mitochondrial_morpho1.41037198
35MP0004145_abnormal_muscle_electrophysio1.39702815
36MP0004885_abnormal_endolymph1.37880034
37MP0001905_abnormal_dopamine_level1.36194604
38MP0006036_abnormal_mitochondrial_physio1.32557549
39MP0002234_abnormal_pharynx_morphology1.31801882
40MP0008260_abnormal_autophagy1.30138522
41MP0003303_peritoneal_inflammation1.30002108
42MP0004142_abnormal_muscle_tone1.29895891
43MP0001293_anophthalmia1.26382853
44MP0005174_abnormal_tail_pigmentation1.25405485
45MP0002160_abnormal_reproductive_system1.24858772
46MP0001800_abnormal_humoral_immune1.24597125
47MP0002733_abnormal_thermal_nociception1.24331577
48MP0005389_reproductive_system_phenotype1.24101844
49MP0006082_CNS_inflammation1.23986004
50MP0008875_abnormal_xenobiotic_pharmacok1.19753468
51MP0005085_abnormal_gallbladder_physiolo1.19363196
52MP0000372_irregular_coat_pigmentation1.16189138
53MP0005253_abnormal_eye_physiology1.15125290
54MP0001485_abnormal_pinna_reflex1.14631222
55MP0002139_abnormal_hepatobiliary_system1.14042118
56MP0005000_abnormal_immune_tolerance1.12061775
57MP0003890_abnormal_embryonic-extraembry1.11363716
58MP0000015_abnormal_ear_pigmentation1.06951699
59MP0002735_abnormal_chemical_nociception1.06768237
60MP0001881_abnormal_mammary_gland1.05246845
61MP0009333_abnormal_splenocyte_physiolog1.04974803
62MP0002723_abnormal_immune_serum1.03511472
63MP0001501_abnormal_sleep_pattern1.02576949
64MP0003724_increased_susceptibility_to1.02272010
65MP0001529_abnormal_vocalization1.01463483
66MP0003011_delayed_dark_adaptation1.01379850
67MP0008873_increased_physiological_sensi1.00866805
68MP0002163_abnormal_gland_morphology0.99060154
69MP0009785_altered_susceptibility_to0.98564809
70MP0005645_abnormal_hypothalamus_physiol0.96794640
71MP0009250_abnormal_appendicular_skeleto0.92428861
72MP0002452_abnormal_antigen_presenting0.92208355
73MP0009765_abnormal_xenobiotic_induced0.92144421
74MP0004133_heterotaxia0.91769932
75MP0000230_abnormal_systemic_arterial0.90964957
76MP0002822_catalepsy0.85542848
77MP0005195_abnormal_posterior_eye0.85077062
78MP0002398_abnormal_bone_marrow0.84394230
79MP0001970_abnormal_pain_threshold0.81324437
80MP0003787_abnormal_imprinting0.80896838
81MP0002420_abnormal_adaptive_immunity0.80805114
82MP0004215_abnormal_myocardial_fiber0.80798413
83MP0005551_abnormal_eye_electrophysiolog0.80636689
84MP0003878_abnormal_ear_physiology0.79885533
85MP0005377_hearing/vestibular/ear_phenot0.79885533
86MP0001119_abnormal_female_reproductive0.79767771
87MP0002272_abnormal_nervous_system0.79209906
88MP0001819_abnormal_immune_cell0.78945917
89MP0003786_premature_aging0.75607572
90MP0003866_abnormal_defecation0.72840139
91MP0002277_abnormal_respiratory_mucosa0.72010296
92MP0002127_abnormal_cardiovascular_syste0.70359580
93MP0002572_abnormal_emotion/affect_behav0.68871881
94MP0001919_abnormal_reproductive_system0.68611329
95MP0000579_abnormal_nail_morphology0.67903916
96MP0000689_abnormal_spleen_morphology0.66653606
97MP0010155_abnormal_intestine_physiology0.66546560
98MP0004924_abnormal_behavior0.64245086
99MP0005386_behavior/neurological_phenoty0.64245086
100MP0005220_abnormal_exocrine_pancreas0.63061669

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)6.81411701
2Hypobetalipoproteinemia (HP:0003563)5.23923547
3Acanthocytosis (HP:0001927)4.77978433
4Neurodegeneration (HP:0002180)4.62735752
5Dyskinesia (HP:0100660)4.60291374
6Methylmalonic acidemia (HP:0002912)4.58545298
7Akinesia (HP:0002304)4.36392143
8Patent foramen ovale (HP:0001655)4.00759547
9Abnormality of the phalanges of the 2nd finger (HP:0009541)3.77998355
10Delayed CNS myelination (HP:0002188)3.70914985
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42093539
12Methylmalonic aciduria (HP:0012120)3.36766021
13Decreased muscle mass (HP:0003199)3.28436350
14Clumsiness (HP:0002312)3.23918133
15Elevated erythrocyte sedimentation rate (HP:0003565)3.12278429
16Diminished movement (HP:0002374)3.10373183
17Abnormality of the vitamin B12 metabolism (HP:0004341)3.08252250
18Brushfield spots (HP:0001088)3.04567195
19Hyperglycinemia (HP:0002154)2.99367438
20Abnormality of vitamin B metabolism (HP:0004340)2.87782933
21Abnormality of the basal ganglia (HP:0002134)2.85013512
22Agitation (HP:0000713)2.81281113
23Dysphonia (HP:0001618)2.78617079
24Large eyes (HP:0001090)2.77925585
25Hemiplegia (HP:0002301)2.72964582
26Aplasia/hypoplasia of the uterus (HP:0008684)2.65488630
27Eosinophilia (HP:0001880)2.57781328
28Carpal bone hypoplasia (HP:0001498)2.55244740
29CNS demyelination (HP:0007305)2.54312312
30Congenital stationary night blindness (HP:0007642)2.52125376
31Panhypogammaglobulinemia (HP:0003139)2.51392485
32Stenosis of the external auditory canal (HP:0000402)2.49986079
33Hypoproteinemia (HP:0003075)2.47948730
34Increased CSF lactate (HP:0002490)2.39212921
35Hepatic necrosis (HP:0002605)2.39063881
36Abnormality of cells of the erythroid lineage (HP:0012130)2.34768194
37Hepatocellular necrosis (HP:0001404)2.32473239
38Abnormality of the pons (HP:0007361)2.30482467
39Congenital, generalized hypertrichosis (HP:0004540)2.29434873
40Restlessness (HP:0000711)2.24938524
41Abnormality of alanine metabolism (HP:0010916)2.24304289
42Hyperalaninemia (HP:0003348)2.24304289
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24304289
44Abnormality of fatty-acid metabolism (HP:0004359)2.23033936
45Parakeratosis (HP:0001036)2.22817319
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22618772
47Hypoplasia of the uterus (HP:0000013)2.14080127
48Abnormality of the 2nd finger (HP:0004100)2.13622255
49Pancreatic cysts (HP:0001737)2.11078018
50Amblyopia (HP:0000646)2.10432807
51Abolished electroretinogram (ERG) (HP:0000550)2.09719487
52Pendular nystagmus (HP:0012043)2.06829011
53Granulocytopenia (HP:0001913)2.06255306
54Abnormality of eosinophils (HP:0001879)2.05497350
55Craniofacial dystonia (HP:0012179)2.04400670
56Tubulointerstitial nephritis (HP:0001970)2.03652849
57Molar tooth sign on MRI (HP:0002419)2.00274127
58Abnormality of midbrain morphology (HP:0002418)2.00274127
59Keratoconus (HP:0000563)1.99572590
60Increased corneal curvature (HP:0100692)1.99572590
61Mitochondrial inheritance (HP:0001427)1.99286027
62Fibular aplasia (HP:0002990)1.97773692
63Hypoplasia of the pons (HP:0012110)1.97082327
64Absent thumb (HP:0009777)1.97014820
65Abnormality of serum amino acid levels (HP:0003112)1.95067127
66Poikilocytosis (HP:0004447)1.94758186
67Epiphyseal stippling (HP:0010655)1.92833625
68Chronic hepatic failure (HP:0100626)1.91079350
69Long nose (HP:0003189)1.90743737
70Congenital sensorineural hearing impairment (HP:0008527)1.90593722
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87233681
72Agammaglobulinemia (HP:0004432)1.86925239
73Microretrognathia (HP:0000308)1.86624595
74Colon cancer (HP:0003003)1.85311579
75Decreased circulating renin level (HP:0003351)1.85301379
76Clubbing of toes (HP:0100760)1.84675573
77Focal dystonia (HP:0004373)1.84501229
78Abnormality of vitamin metabolism (HP:0100508)1.83863249
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.83435078
80Broad distal phalanx of finger (HP:0009836)1.82438383
81Abnormality of B cell number (HP:0010975)1.81643081
82Choreoathetosis (HP:0001266)1.81612864
83Increased serum lactate (HP:0002151)1.81612524
84Abnormality of glycine metabolism (HP:0010895)1.81481678
85Abnormality of serine family amino acid metabolism (HP:0010894)1.81481678
86Chorioretinal atrophy (HP:0000533)1.80281972
87Hypolipoproteinemia (HP:0010981)1.79672468
88Meckel diverticulum (HP:0002245)1.78392264
89Congenital glaucoma (HP:0001087)1.76944380
90Morphological abnormality of the pyramidal tract (HP:0002062)1.76600807
91Abnormality of glycolipid metabolism (HP:0010969)1.75382755
92Abnormality of liposaccharide metabolism (HP:0010968)1.75382755
93Abnormality of glycosphingolipid metabolism (HP:0004343)1.75382755
94Asplenia (HP:0001746)1.74985924
95Leukocytosis (HP:0001974)1.72788238
96Orchitis (HP:0100796)1.71617314
97Abnormality of the ileum (HP:0001549)1.71515074
98Small epiphyses (HP:0010585)1.71114268
99Attenuation of retinal blood vessels (HP:0007843)1.70939944
100Increased hepatocellular lipid droplets (HP:0006565)1.70861745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.48075460
2PDK23.35661361
3VRK23.19309123
4ERN13.15407083
5ZAK2.96468493
6MAP2K62.72116755
7TLK12.48052200
8NUAK12.44601800
9FRK2.32210456
10MAP4K22.31755281
11TAOK31.89690071
12ADRBK21.87237522
13MST41.82552845
14FES1.79925516
15TIE11.75749312
16SRPK11.69482267
17PINK11.61216604
18MAPKAPK31.60349850
19GRK11.56064752
20TRIM281.48454910
21TGFBR11.47123375
22TXK1.42097935
23TBK11.41759353
24PASK1.33046721
25EIF2AK11.27328769
26AKT21.21623126
27PLK31.19930138
28WNK41.19790896
29PLK21.19380174
30TAF11.19199231
31MAPKAPK51.17487221
32MAP3K61.16829280
33VRK11.15395609
34LCK1.15230064
35CCNB11.12649333
36KDR1.12144954
37OXSR11.09933992
38SYK1.07722603
39STK161.02659198
40BMPR1B0.99191070
41CAMKK20.97409609
42EIF2AK20.96090133
43GRK50.94642455
44IKBKB0.94556505
45KIT0.93606379
46INSRR0.91159547
47CSNK1G30.90572890
48CSF1R0.88505031
49MUSK0.86495418
50WNK30.84976048
51STK390.84495646
52LIMK10.84030109
53PHKG20.79999829
54PHKG10.79999829
55STK38L0.78426268
56ADRBK10.77607879
57STK30.76976892
58MAP3K140.76641559
59PKN10.73599767
60DAPK10.71548017
61MAP3K120.70930083
62PRKCH0.70671931
63BCKDK0.66836696
64CSNK1G10.66297912
65CSNK1G20.64852707
66RPS6KB20.63753980
67NEK20.62759788
68PIK3CG0.62099690
69ROCK20.61287664
70PRKCQ0.60184803
71ROCK10.57915740
72MKNK20.57886749
73MKNK10.56128731
74ITK0.55990124
75TEC0.54800683
76PLK40.52735002
77NEK10.51878566
78ABL20.51575779
79CSNK1A1L0.51494292
80OBSCN0.51016272
81MYLK0.50682173
82RPS6KB10.50565488
83TESK20.49222388
84MAP4K10.48938781
85MAP3K130.48909581
86IKBKE0.48653916
87PRKCA0.48502256
88DAPK30.48204706
89ATR0.47091379
90PRKCG0.46264859
91PRKCE0.42442476
92PRKCD0.42435526
93CSNK2A10.42245608
94DYRK20.41028512
95WNK10.38813090
96MAP2K10.38606971
97MINK10.37298501
98CAMK2A0.37260910
99GRK70.37006108
100PIM10.36912129

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.84546313
2Ribosome_Homo sapiens_hsa030103.72582777
3Selenocompound metabolism_Homo sapiens_hsa004502.86830697
4Linoleic acid metabolism_Homo sapiens_hsa005912.57898784
5Asthma_Homo sapiens_hsa053102.56797634
6Proteasome_Homo sapiens_hsa030502.54768036
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48035226
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.41864957
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.37515123
10Allograft rejection_Homo sapiens_hsa053302.37271113
11Autoimmune thyroid disease_Homo sapiens_hsa053202.25419497
12Graft-versus-host disease_Homo sapiens_hsa053322.13242547
13Regulation of autophagy_Homo sapiens_hsa041402.10701143
14RNA degradation_Homo sapiens_hsa030182.04313961
15Type I diabetes mellitus_Homo sapiens_hsa049401.77569880
16Parkinsons disease_Homo sapiens_hsa050121.71584866
17Oxidative phosphorylation_Homo sapiens_hsa001901.66021396
18Nitrogen metabolism_Homo sapiens_hsa009101.62133224
19Propanoate metabolism_Homo sapiens_hsa006401.60356970
20Primary immunodeficiency_Homo sapiens_hsa053401.49674380
21Peroxisome_Homo sapiens_hsa041461.47450804
22Fructose and mannose metabolism_Homo sapiens_hsa000511.46793440
23Tryptophan metabolism_Homo sapiens_hsa003801.46458653
24Ether lipid metabolism_Homo sapiens_hsa005651.43880176
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35086382
26Protein export_Homo sapiens_hsa030601.35034919
27Caffeine metabolism_Homo sapiens_hsa002321.34109343
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32191182
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30940994
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30699598
31Arachidonic acid metabolism_Homo sapiens_hsa005901.29325560
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27620068
33RNA polymerase_Homo sapiens_hsa030201.26043793
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.24018522
35Basal transcription factors_Homo sapiens_hsa030221.21651194
36Mismatch repair_Homo sapiens_hsa034301.16676684
37Fanconi anemia pathway_Homo sapiens_hsa034601.16635877
38Base excision repair_Homo sapiens_hsa034101.14764484
39Homologous recombination_Homo sapiens_hsa034401.14244194
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10798232
41Phototransduction_Homo sapiens_hsa047441.10488564
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07495820
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07267771
44Alzheimers disease_Homo sapiens_hsa050101.05772506
45Antigen processing and presentation_Homo sapiens_hsa046120.99075702
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98240194
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93505276
48Fat digestion and absorption_Homo sapiens_hsa049750.91847698
49Nucleotide excision repair_Homo sapiens_hsa034200.90972313
50Butanoate metabolism_Homo sapiens_hsa006500.90392785
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89414291
52DNA replication_Homo sapiens_hsa030300.89363163
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87790360
54Purine metabolism_Homo sapiens_hsa002300.86105192
55Rheumatoid arthritis_Homo sapiens_hsa053230.81289000
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80379020
57Retinol metabolism_Homo sapiens_hsa008300.79698895
58Chemical carcinogenesis_Homo sapiens_hsa052040.79141497
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78060672
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77945900
61One carbon pool by folate_Homo sapiens_hsa006700.74651825
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.73509014
63Cardiac muscle contraction_Homo sapiens_hsa042600.73042940
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72839816
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71100583
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70869720
67Fatty acid elongation_Homo sapiens_hsa000620.70514710
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70133211
69Huntingtons disease_Homo sapiens_hsa050160.67860403
70Hematopoietic cell lineage_Homo sapiens_hsa046400.61743987
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61628523
72Viral myocarditis_Homo sapiens_hsa054160.60590452
73Pyrimidine metabolism_Homo sapiens_hsa002400.60488249
74Non-homologous end-joining_Homo sapiens_hsa034500.58916406
75Olfactory transduction_Homo sapiens_hsa047400.57294282
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54385159
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53187684
78Leishmaniasis_Homo sapiens_hsa051400.51221535
79Staphylococcus aureus infection_Homo sapiens_hsa051500.50981504
80Spliceosome_Homo sapiens_hsa030400.50821644
81Metabolic pathways_Homo sapiens_hsa011000.48069590
82Systemic lupus erythematosus_Homo sapiens_hsa053220.46392547
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.44852199
84Taste transduction_Homo sapiens_hsa047420.40245178
85Renin-angiotensin system_Homo sapiens_hsa046140.39559941
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.39076977
87RNA transport_Homo sapiens_hsa030130.38826540
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38603981
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.37806121
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.37579390
91Vitamin digestion and absorption_Homo sapiens_hsa049770.37484417
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36957608
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35702186
94Fatty acid degradation_Homo sapiens_hsa000710.35673358
95Serotonergic synapse_Homo sapiens_hsa047260.35329987
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.34456328
97Glutathione metabolism_Homo sapiens_hsa004800.31639611
98Glycerolipid metabolism_Homo sapiens_hsa005610.30393003
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26806785
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25849810

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