ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.33133169
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.10402912
3	DNA double-strand break processing (GO:0000729)	4.01617302
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.79036977
5	behavioral response to nicotine (GO:0035095)	3.78131304
6	DNA deamination (GO:0045006)	3.73526640
7	protein complex biogenesis (GO:0070271)	3.72736861
8	response to pheromone (GO:0019236)	3.69694280
9	replication fork processing (GO:0031297)	3.65759357
10	ATP synthesis coupled proton transport (GO:0015986)	3.60414379
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.60414379
12	NADH dehydrogenase complex assembly (GO:0010257)	3.55676788
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55676788
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55676788
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.39567639
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39322578
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.35892210
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.24866730
19	respiratory chain complex IV assembly (GO:0008535)	3.23925502
20	lactate metabolic process (GO:0006089)	3.22702773
21	GTP biosynthetic process (GO:0006183)	3.16330030
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.15463126
23	ribosomal small subunit assembly (GO:0000028)	3.06117721
24	positive regulation of interleukin-17 production (GO:0032740)	3.04226670
25	platelet dense granule organization (GO:0060155)	3.02604803
26	negative regulation of telomere maintenance (GO:0032205)	3.02188445
27	nonmotile primary cilium assembly (GO:0035058)	2.97071086
28	recombinational repair (GO:0000725)	2.96849228
29	double-strand break repair via homologous recombination (GO:0000724)	2.95572798
30	fucose catabolic process (GO:0019317)	2.95385052
31	L-fucose metabolic process (GO:0042354)	2.95385052
32	L-fucose catabolic process (GO:0042355)	2.95385052
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92506951
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92506951
35	cytochrome complex assembly (GO:0017004)	2.91688214
36	cullin deneddylation (GO:0010388)	2.91515254
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.91154577
38	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.89995615
39	positive regulation of natural killer cell differentiation (GO:0032825)	2.89788123
40	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.87951046
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.87043835
42	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.84420750
43	epithelial cilium movement (GO:0003351)	2.80803299
44	chaperone-mediated protein transport (GO:0072321)	2.80356656
45	kidney morphogenesis (GO:0060993)	2.79702482
46	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.74920210
47	regulation of cilium movement (GO:0003352)	2.72178411
48	indolalkylamine metabolic process (GO:0006586)	2.71497614
49	electron transport chain (GO:0022900)	2.70438323
50	cellular ketone body metabolic process (GO:0046950)	2.66638898
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.65728307
52	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.65623939
53	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.65623939
54	isotype switching (GO:0045190)	2.65623939
55	protein deneddylation (GO:0000338)	2.65023226
56	rRNA modification (GO:0000154)	2.64891187
57	DNA catabolic process, exonucleolytic (GO:0000738)	2.64574594
58	respiratory electron transport chain (GO:0022904)	2.64444027
59	regulation of meiosis I (GO:0060631)	2.64199722
60	proteasome assembly (GO:0043248)	2.59606719
61	male meiosis I (GO:0007141)	2.57650913
62	S-adenosylmethionine metabolic process (GO:0046500)	2.55231677
63	chromatin remodeling at centromere (GO:0031055)	2.54419600
64	UTP biosynthetic process (GO:0006228)	2.54270216
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.53860204
66	intraciliary transport (GO:0042073)	2.53355073
67	kynurenine metabolic process (GO:0070189)	2.52651057
68	somite development (GO:0061053)	2.51920132
69	termination of RNA polymerase III transcription (GO:0006386)	2.50329227
70	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50329227
71	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.50312684
72	protein localization to cilium (GO:0061512)	2.49216214
73	pseudouridine synthesis (GO:0001522)	2.48641571
74	UTP metabolic process (GO:0046051)	2.48364834
75	tRNA processing (GO:0008033)	2.47553982
76	regulation of telomere maintenance (GO:0032204)	2.46366881
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.45507502
78	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.45112936
79	prenylation (GO:0097354)	2.44287198
80	protein prenylation (GO:0018342)	2.44287198
81	ketone body metabolic process (GO:1902224)	2.44030773
82	ubiquinone biosynthetic process (GO:0006744)	2.43721361
83	CTP metabolic process (GO:0046036)	2.42352075
84	CTP biosynthetic process (GO:0006241)	2.42352075
85	peptidyl-histidine modification (GO:0018202)	2.42047380
86	tryptophan catabolic process (GO:0006569)	2.41938795
87	indole-containing compound catabolic process (GO:0042436)	2.41938795
88	indolalkylamine catabolic process (GO:0046218)	2.41938795
89	protein polyglutamylation (GO:0018095)	2.41582897
90	synapsis (GO:0007129)	2.39737841
91	positive regulation of prostaglandin secretion (GO:0032308)	2.39107558
92	cell proliferation in forebrain (GO:0021846)	2.36303062
93	resolution of meiotic recombination intermediates (GO:0000712)	2.36118119
94	anterograde synaptic vesicle transport (GO:0048490)	2.35454069
95	positive regulation of cell fate commitment (GO:0010455)	2.35327503
96	positive regulation of respiratory burst (GO:0060267)	2.35158375
97	ubiquinone metabolic process (GO:0006743)	2.34282032
98	intracellular protein transmembrane import (GO:0044743)	2.33899741
99	mechanosensory behavior (GO:0007638)	2.32844753
100	protein-cofactor linkage (GO:0018065)	2.32546957

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.11496261
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.23356929
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19122179
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16381975
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.09878580
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75376429
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54688334
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47968191
9	FUS_26573619_Chip-Seq_HEK293_Human	2.43348408
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37204494
11	EWS_26573619_Chip-Seq_HEK293_Human	2.35288495
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.33960654
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21953536
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19724450
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.13622579
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.06705241
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99754661
18	P300_19829295_ChIP-Seq_ESCs_Human	1.93952818
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.93933526
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93409108
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92905594
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.86409108
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.83452110
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.79984081
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78716417
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.75886068
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.72629638
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71764094
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71382598
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71330909
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70650107
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.70482271
33	EZH2_22144423_ChIP-Seq_EOC_Human	1.64217454
34	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63552555
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61352107
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56780758
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55675086
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54054279
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51829103
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50390287
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.48816829
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.48131425
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.46803077
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.46432655
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45175977
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40151509
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36245349
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.35563595
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35563595
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35467096
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34478174
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.30884672
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30597016
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30005565
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30005565
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29002647
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27613200
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26046052
59	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.24535062
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22659337
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22389073
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21482797
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20731211
64	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.18916884
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18679006
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16603310
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16603310
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16321290
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16162665
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15863175
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15484212
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14425719
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14079339
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12766786
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11929543
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11668120
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11376744
78	AR_25329375_ChIP-Seq_VCAP_Human	1.11325736
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11144898
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10560889
81	STAT3_23295773_ChIP-Seq_U87_Human	1.09344994
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09002216
83	TCF4_23295773_ChIP-Seq_U87_Human	1.08465143
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08178382
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08178382
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07833442
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07477367
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07303042
89	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06758295
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06506611
91	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06406719
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04916965
93	AR_20517297_ChIP-Seq_VCAP_Human	1.04587682
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04394064
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03690344
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.03547418
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03089222
98	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.01680688
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01551028
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01008713

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.80835245
2	MP0008877_abnormal_DNA_methylation	2.96724044
3	MP0002102_abnormal_ear_morphology	2.77513242
4	MP0002736_abnormal_nociception_after	2.73932467
5	MP0002837_dystrophic_cardiac_calcinosis	2.44808941
6	MP0003787_abnormal_imprinting	2.39099043
7	MP0002938_white_spotting	2.35201346
8	MP0001968_abnormal_touch/_nociception	2.27913295
9	MP0000372_irregular_coat_pigmentation	2.21548366
10	MP0004885_abnormal_endolymph	2.19906671
11	MP0006072_abnormal_retinal_apoptosis	2.10456406
12	MP0008872_abnormal_physiological_respon	2.08026703
13	MP0008058_abnormal_DNA_repair	1.99080656
14	MP0008789_abnormal_olfactory_epithelium	1.92478534
15	MP0005551_abnormal_eye_electrophysiolog	1.85909805
16	MP0004142_abnormal_muscle_tone	1.82595443
17	MP0000569_abnormal_digit_pigmentation	1.79701018
18	MP0003880_abnormal_central_pattern	1.76239497
19	MP0001984_abnormal_olfaction	1.67210719
20	MP0003121_genomic_imprinting	1.62845120
21	MP0001485_abnormal_pinna_reflex	1.61247446
22	MP0004742_abnormal_vestibular_system	1.61090000
23	MP0003195_calcinosis	1.59168900
24	MP0000631_abnormal_neuroendocrine_gland	1.58540958
25	MP0008875_abnormal_xenobiotic_pharmacok	1.57890374
26	MP0002272_abnormal_nervous_system	1.56657153
27	MP0003646_muscle_fatigue	1.55992945
28	MP0006276_abnormal_autonomic_nervous	1.55700255
29	MP0004145_abnormal_muscle_electrophysio	1.54753179
30	MP0002160_abnormal_reproductive_system	1.48250707
31	MP0001529_abnormal_vocalization	1.47485746
32	MP0005253_abnormal_eye_physiology	1.44556871
33	MP0005389_reproductive_system_phenotype	1.37893363
34	MP0001486_abnormal_startle_reflex	1.36727284
35	MP0002653_abnormal_ependyma_morphology	1.33858700
36	MP0004133_heterotaxia	1.33546003
37	MP0009379_abnormal_foot_pigmentation	1.32202749
38	MP0002638_abnormal_pupillary_reflex	1.31677197
39	MP0001348_abnormal_lacrimal_gland	1.29836088
40	MP0003786_premature_aging	1.28802493
41	MP0009745_abnormal_behavioral_response	1.27839561
42	MP0005075_abnormal_melanosome_morpholog	1.27583216
43	MP0001986_abnormal_taste_sensitivity	1.27402855
44	MP0004147_increased_porphyrin_level	1.27282641
45	MP0005394_taste/olfaction_phenotype	1.26430186
46	MP0005499_abnormal_olfactory_system	1.26430186
47	MP0002876_abnormal_thyroid_physiology	1.26327807
48	MP0003718_maternal_effect	1.26185880
49	MP0005645_abnormal_hypothalamus_physiol	1.25768960
50	MP0005174_abnormal_tail_pigmentation	1.25687841
51	MP0008995_early_reproductive_senescence	1.23868379
52	MP0009046_muscle_twitch	1.23019292
53	MP0005646_abnormal_pituitary_gland	1.21860438
54	MP0002234_abnormal_pharynx_morphology	1.21332693
55	MP0005084_abnormal_gallbladder_morpholo	1.21283013
56	MP0001188_hyperpigmentation	1.20320009
57	MP0003122_maternal_imprinting	1.19730926
58	MP0000427_abnormal_hair_cycle	1.17638929
59	MP0003567_abnormal_fetal_cardiomyocyte	1.17035776
60	MP0003938_abnormal_ear_development	1.13629954
61	MP0002163_abnormal_gland_morphology	1.13063105
62	MP0003011_delayed_dark_adaptation	1.12955484
63	MP0001919_abnormal_reproductive_system	1.11789596
64	MP0002751_abnormal_autonomic_nervous	1.11495563
65	MP0008775_abnormal_heart_ventricle	1.09452312
66	MP0002184_abnormal_innervation	1.04868277
67	MP0002557_abnormal_social/conspecific_i	1.03942997
68	MP0001873_stomach_inflammation	1.01800753
69	MP0002095_abnormal_skin_pigmentation	1.00894781
70	MP0001293_anophthalmia	1.00771164
71	MP0005379_endocrine/exocrine_gland_phen	0.99406941
72	MP0002233_abnormal_nose_morphology	0.97788877
73	MP0005408_hypopigmentation	0.97503885
74	MP0005195_abnormal_posterior_eye	0.97424687
75	MP0000026_abnormal_inner_ear	0.97177540
76	MP0002210_abnormal_sex_determination	0.97162229
77	MP0000647_abnormal_sebaceous_gland	0.92882007
78	MP0001963_abnormal_hearing_physiology	0.91946408
79	MP0000049_abnormal_middle_ear	0.88997752
80	MP0005410_abnormal_fertilization	0.88184805
81	MP0002572_abnormal_emotion/affect_behav	0.87622819
82	MP0002752_abnormal_somatic_nervous	0.87516021
83	MP0003186_abnormal_redox_activity	0.87382202
84	MP0000778_abnormal_nervous_system	0.87176014
85	MP0002254_reproductive_system_inflammat	0.86058972
86	MP0001501_abnormal_sleep_pattern	0.85702753
87	MP0001929_abnormal_gametogenesis	0.85664805
88	MP0001905_abnormal_dopamine_level	0.82891727
89	MP0003890_abnormal_embryonic-extraembry	0.82474443
90	MP0004043_abnormal_pH_regulation	0.82425755
91	MP0002277_abnormal_respiratory_mucosa	0.81812336
92	MP0002282_abnormal_trachea_morphology	0.81173320
93	MP0002067_abnormal_sensory_capabilities	0.80988442
94	MP0000653_abnormal_sex_gland	0.79347933
95	MP0002735_abnormal_chemical_nociception	0.79189228
96	MP0010094_abnormal_chromosome_stability	0.78475298
97	MP0001970_abnormal_pain_threshold	0.78084681
98	MP0001764_abnormal_homeostasis	0.77617408
99	MP0002229_neurodegeneration	0.76831596
100	MP0003937_abnormal_limbs/digits/tail_de	0.76327264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.91498497
2	Pancreatic cysts (HP:0001737)	3.65693927
3	Acute encephalopathy (HP:0006846)	3.54135396
4	Pancreatic fibrosis (HP:0100732)	3.53642909
5	Molar tooth sign on MRI (HP:0002419)	3.53229844
6	Abnormality of midbrain morphology (HP:0002418)	3.53229844
7	Progressive macrocephaly (HP:0004481)	3.52888005
8	True hermaphroditism (HP:0010459)	3.43231549
9	Nephronophthisis (HP:0000090)	3.28672847
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.22659028
11	Medial flaring of the eyebrow (HP:0010747)	3.18274641
12	Mitochondrial inheritance (HP:0001427)	3.17872586
13	Septo-optic dysplasia (HP:0100842)	3.01545364
14	Increased CSF lactate (HP:0002490)	2.96612675
15	Congenital stationary night blindness (HP:0007642)	2.93860884
16	Abnormality of the labia minora (HP:0012880)	2.88148277
17	Increased hepatocellular lipid droplets (HP:0006565)	2.81883907
18	Abnormality of the renal medulla (HP:0100957)	2.79922695
19	Cystic liver disease (HP:0006706)	2.77070572
20	Methylmalonic acidemia (HP:0002912)	2.76021987
21	Colon cancer (HP:0003003)	2.62115369
22	Cerebral edema (HP:0002181)	2.56163938
23	Abnormality of the renal cortex (HP:0011035)	2.54956369
24	Lipid accumulation in hepatocytes (HP:0006561)	2.53770206
25	Reticulocytopenia (HP:0001896)	2.52575765
26	Gait imbalance (HP:0002141)	2.52525990
27	Congenital primary aphakia (HP:0007707)	2.51377123
28	Hyperglycinemia (HP:0002154)	2.51161765
29	Volvulus (HP:0002580)	2.49934719
30	Congenital, generalized hypertrichosis (HP:0004540)	2.47943068
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42908971
32	Methylmalonic aciduria (HP:0012120)	2.40692278
33	Nephrogenic diabetes insipidus (HP:0009806)	2.38829246
34	Optic disc pallor (HP:0000543)	2.34775989
35	Hepatocellular necrosis (HP:0001404)	2.33100006
36	Optic nerve hypoplasia (HP:0000609)	2.29373860
37	Exertional dyspnea (HP:0002875)	2.23828531
38	Type II lissencephaly (HP:0007260)	2.22763207
39	Adrenal hypoplasia (HP:0000835)	2.22318725
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19529115
41	Abnormality of the ileum (HP:0001549)	2.19262270
42	Pendular nystagmus (HP:0012043)	2.18916364
43	Intestinal atresia (HP:0011100)	2.15576731
44	Meckel diverticulum (HP:0002245)	2.13749825
45	Sclerocornea (HP:0000647)	2.11667554
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11575402
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11311830
48	Postaxial foot polydactyly (HP:0001830)	2.10150146
49	Renal Fanconi syndrome (HP:0001994)	2.09497021
50	Hepatic necrosis (HP:0002605)	2.07075881
51	Genital tract atresia (HP:0001827)	2.03746528
52	Chromsome breakage (HP:0040012)	2.02146374
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.01683621
54	Febrile seizures (HP:0002373)	2.01120568
55	Abolished electroretinogram (ERG) (HP:0000550)	2.01073519
56	Chronic hepatic failure (HP:0100626)	2.00722933
57	3-Methylglutaconic aciduria (HP:0003535)	2.00467388
58	Vaginal atresia (HP:0000148)	1.99548247
59	Hyperventilation (HP:0002883)	1.98967083
60	Bile duct proliferation (HP:0001408)	1.98366705
61	Abnormal biliary tract physiology (HP:0012439)	1.98366705
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96802615
63	Supernumerary spleens (HP:0009799)	1.96621587
64	Anencephaly (HP:0002323)	1.94711893
65	Male pseudohermaphroditism (HP:0000037)	1.94394134
66	Abnormality of chromosome stability (HP:0003220)	1.91083377
67	Occipital encephalocele (HP:0002085)	1.90602848
68	Increased corneal curvature (HP:0100692)	1.89171829
69	Keratoconus (HP:0000563)	1.89171829
70	Congenital hepatic fibrosis (HP:0002612)	1.88667922
71	Polydipsia (HP:0001959)	1.88319058
72	Abnormal drinking behavior (HP:0030082)	1.88319058
73	Postaxial hand polydactyly (HP:0001162)	1.86526040
74	Increased serum lactate (HP:0002151)	1.84975513
75	Growth hormone deficiency (HP:0000824)	1.84696939
76	Abnormality of the preputium (HP:0100587)	1.84549915
77	Absent thumb (HP:0009777)	1.83783370
78	Lethargy (HP:0001254)	1.83584753
79	Triphalangeal thumb (HP:0001199)	1.82945291
80	Thyroiditis (HP:0100646)	1.82356661
81	Tubular atrophy (HP:0000092)	1.82175617
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81704673
83	Asplenia (HP:0001746)	1.81254420
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81138744
85	Renal cortical cysts (HP:0000803)	1.80676551
86	Poor coordination (HP:0002370)	1.74329302
87	Abnormality of glycine metabolism (HP:0010895)	1.72486431
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72486431
89	Preaxial hand polydactyly (HP:0001177)	1.71185192
90	Type 2 muscle fiber atrophy (HP:0003554)	1.70703245
91	Abnormality of the pons (HP:0007361)	1.70419010
92	Ketosis (HP:0001946)	1.69961370
93	Chorioretinal atrophy (HP:0000533)	1.69433036
94	Abnormal ciliary motility (HP:0012262)	1.69350083
95	Lactic acidosis (HP:0003128)	1.69162505
96	Hypothermia (HP:0002045)	1.68244754
97	Abnormality of vitamin B metabolism (HP:0004340)	1.68217765
98	Ectopic kidney (HP:0000086)	1.67918024
99	Polyuria (HP:0000103)	1.67269720
100	Focal motor seizures (HP:0011153)	1.67063012

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.37474373
2	MAP4K2	3.09316935
3	NUAK1	2.53352843
4	EIF2AK3	2.49281272
5	TRIM28	2.24863684
6	WNK3	2.13282085
7	MST4	2.08242145
8	ZAK	2.04597767
9	ADRBK2	1.98878469
10	CASK	1.95940638
11	EIF2AK1	1.93093280
12	MKNK2	1.87226972
13	GRK1	1.86225270
14	TNIK	1.81043687
15	ACVR1B	1.80257388
16	NEK1	1.78589492
17	INSRR	1.75374213
18	VRK2	1.74573505
19	STK16	1.66966877
20	BMPR1B	1.62312747
21	WNK4	1.62262827
22	AKT3	1.62112572
23	STK39	1.60879165
24	NME1	1.57187820
25	PAK3	1.55900540
26	BCKDK	1.54094734
27	OXSR1	1.49612645
28	TSSK6	1.49408447
29	MKNK1	1.48615828
30	BRSK2	1.47941900
31	VRK1	1.41954441
32	PLK3	1.38244582
33	MAP3K4	1.32387219
34	MAPK13	1.31464124
35	MUSK	1.23712001
36	ERBB3	1.19666194
37	DYRK2	1.17052508
38	PNCK	1.13530098
39	WEE1	1.13365871
40	PINK1	1.10457207
41	PLK2	1.05255134
42	MAP2K6	1.02696744
43	CAMKK2	0.99626059
44	PLK4	0.99150511
45	BCR	0.97894056
46	TAF1	0.94686646
47	NLK	0.88470071
48	PAK6	0.86426030
49	PRKCE	0.85459172
50	PASK	0.82838786
51	TLK1	0.81940074
52	PRKCG	0.80455817
53	TXK	0.76710484
54	CSNK1G1	0.76038200
55	CSNK1G2	0.74670766
56	KSR1	0.73150853
57	PLK1	0.71139924
58	MAP3K12	0.70737801
59	BUB1	0.70443069
60	EIF2AK2	0.70401853
61	CDC7	0.68627416
62	TEC	0.68390826
63	TGFBR1	0.66575888
64	STK38L	0.64748897
65	ADRBK1	0.62205434
66	MAP2K7	0.61240363
67	CSNK1G3	0.61088183
68	SIK3	0.58159139
69	MINK1	0.56981842
70	PBK	0.55737596
71	MARK1	0.54937856
72	CDK19	0.54598497
73	TIE1	0.53923460
74	SRPK1	0.48587145
75	FER	0.46967015
76	MAPKAPK5	0.45714423
77	STK3	0.44802913
78	CSNK1A1L	0.44675778
79	FLT3	0.44530207
80	PHKG2	0.43349514
81	PHKG1	0.43349514
82	ATM	0.41851732
83	PKN1	0.41377609
84	CAMK2A	0.41321735
85	PRKACA	0.41202697
86	CSNK2A2	0.40491110
87	PRKCI	0.40393115
88	SGK2	0.40111582
89	CSNK1A1	0.39809995
90	KIT	0.39256590
91	PRKCQ	0.39223404
92	IRAK1	0.37465049
93	PIK3CA	0.36503949
94	IGF1R	0.36209272
95	CDK3	0.35654059
96	FGFR2	0.35634167
97	PRKG1	0.35561352
98	CAMK1	0.35425847
99	BRSK1	0.35325600
100	CSNK2A1	0.34109001

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.09200386
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01110671
3	Proteasome_Homo sapiens_hsa03050	2.96257565
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.77650878
5	Parkinsons disease_Homo sapiens_hsa05012	2.58364469
6	Ribosome_Homo sapiens_hsa03010	2.51922161
7	Homologous recombination_Homo sapiens_hsa03440	2.45104793
8	RNA polymerase_Homo sapiens_hsa03020	2.33451835
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20754849
10	Propanoate metabolism_Homo sapiens_hsa00640	2.18718813
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10665318
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08534352
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96223452
14	Basal transcription factors_Homo sapiens_hsa03022	1.81855149
15	Mismatch repair_Homo sapiens_hsa03430	1.80705214
16	RNA degradation_Homo sapiens_hsa03018	1.76609242
17	One carbon pool by folate_Homo sapiens_hsa00670	1.72636274
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.71820580
19	Huntingtons disease_Homo sapiens_hsa05016	1.71644547
20	Butanoate metabolism_Homo sapiens_hsa00650	1.67674828
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66175465
22	Phototransduction_Homo sapiens_hsa04744	1.65487248
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65437886
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64684622
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58706314
26	Alzheimers disease_Homo sapiens_hsa05010	1.56967456
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43610928
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41532346
29	Asthma_Homo sapiens_hsa05310	1.40137231
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40121636
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36250111
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.32400311
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.30442089
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.28945858
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.25546157
36	Caffeine metabolism_Homo sapiens_hsa00232	1.25310080
37	RNA transport_Homo sapiens_hsa03013	1.17299515
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.15428962
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10584054
40	Nicotine addiction_Homo sapiens_hsa05033	1.09541562
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05397584
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.04714815
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.01748893
44	Allograft rejection_Homo sapiens_hsa05330	1.01436853
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01402791
46	Peroxisome_Homo sapiens_hsa04146	0.99049563
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99019171
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.97074495
49	Purine metabolism_Homo sapiens_hsa00230	0.96257512
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95971499
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92998313
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91043595
53	Olfactory transduction_Homo sapiens_hsa04740	0.89347827
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80489645
55	Spliceosome_Homo sapiens_hsa03040	0.79824095
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79130816
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77098877
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77062811
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.76400135
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74967567
61	DNA replication_Homo sapiens_hsa03030	0.74848547
62	Retinol metabolism_Homo sapiens_hsa00830	0.71070130
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70472205
64	Metabolic pathways_Homo sapiens_hsa01100	0.69662107
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69457219
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.65273212
67	Sulfur metabolism_Homo sapiens_hsa00920	0.64800090
68	Fatty acid elongation_Homo sapiens_hsa00062	0.63177294
69	Taste transduction_Homo sapiens_hsa04742	0.61465163
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60598714
71	Regulation of autophagy_Homo sapiens_hsa04140	0.60457062
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58364389
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56980604
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56210535
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55876570
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55529777
77	Mineral absorption_Homo sapiens_hsa04978	0.50819417
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50378850
79	Base excision repair_Homo sapiens_hsa03410	0.49799470
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48739930
81	Folate biosynthesis_Homo sapiens_hsa00790	0.47327022
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45678436
83	Insulin secretion_Homo sapiens_hsa04911	0.45607298
84	Glutathione metabolism_Homo sapiens_hsa00480	0.44238130
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.43863384
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43472609
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43356336
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43219235
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42597645
90	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42090077
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.39777833
92	Morphine addiction_Homo sapiens_hsa05032	0.39568828
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.38764020
94	Graft-versus-host disease_Homo sapiens_hsa05332	0.38256704
95	Serotonergic synapse_Homo sapiens_hsa04726	0.37066161
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36234124
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33588775
98	Fatty acid degradation_Homo sapiens_hsa00071	0.32695385
99	p53 signaling pathway_Homo sapiens_hsa04115	0.30063041
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28529167

RPL9P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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