RPL9P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histamine transport (GO:0051608)7.90636431
2meiotic chromosome segregation (GO:0045132)6.91971878
3drug transmembrane transport (GO:0006855)6.69212370
4neurotransmitter biosynthetic process (GO:0042136)6.50859469
5organic cation transport (GO:0015695)6.44547848
6tooth mineralization (GO:0034505)6.44502674
7exogenous drug catabolic process (GO:0042738)6.21362631
8quaternary ammonium group transport (GO:0015697)6.08323207
9neurotransmitter metabolic process (GO:0042133)5.99720007
10behavioral response to nicotine (GO:0035095)5.63483449
11resolution of meiotic recombination intermediates (GO:0000712)5.60078847
12positive regulation of meiosis (GO:0045836)5.20220660
13negative regulation of telomere maintenance (GO:0032205)5.03094893
14bone trabecula formation (GO:0060346)5.01238584
15detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.96256916
16rRNA catabolic process (GO:0016075)4.89417567
17positive regulation of meiotic cell cycle (GO:0051446)4.82340861
18drug catabolic process (GO:0042737)4.65044823
19azole transport (GO:0045117)4.63728437
20drug transport (GO:0015893)4.58613326
21regulation of response to tumor cell (GO:0002834)4.29316892
22positive regulation of response to tumor cell (GO:0002836)4.29316892
23positive regulation of immune response to tumor cell (GO:0002839)4.29316892
24regulation of immune response to tumor cell (GO:0002837)4.29316892
25fatty acid elongation (GO:0030497)4.18949627
26synaptonemal complex assembly (GO:0007130)4.14159940
27negative regulation of transcription regulatory region DNA binding (GO:2000678)4.08981674
28negative regulation of epidermal cell differentiation (GO:0045605)3.93907380
29synaptonemal complex organization (GO:0070193)3.84054573
30regulation of mesenchymal cell apoptotic process (GO:2001053)3.83216285
31kynurenine metabolic process (GO:0070189)3.82776793
32reciprocal meiotic recombination (GO:0007131)3.80075160
33reciprocal DNA recombination (GO:0035825)3.80075160
34positive regulation of hair cycle (GO:0042635)3.76243916
35positive regulation of hair follicle development (GO:0051798)3.76243916
36cilium or flagellum-dependent cell motility (GO:0001539)3.75937845
37epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.73660582
38histone-serine phosphorylation (GO:0035404)3.66707829
39auditory receptor cell stereocilium organization (GO:0060088)3.62920372
40maturation of 5.8S rRNA (GO:0000460)3.53758428
41L-fucose catabolic process (GO:0042355)3.53260364
42fucose catabolic process (GO:0019317)3.53260364
43L-fucose metabolic process (GO:0042354)3.53260364
44detection of chemical stimulus involved in sensory perception (GO:0050907)3.49709821
45C4-dicarboxylate transport (GO:0015740)3.44042609
46fatty acid transmembrane transport (GO:1902001)3.42273331
47rRNA modification (GO:0000154)3.40058387
48indole-containing compound catabolic process (GO:0042436)3.40014031
49indolalkylamine catabolic process (GO:0046218)3.40014031
50tryptophan catabolic process (GO:0006569)3.40014031
51rRNA methylation (GO:0031167)3.37310323
52positive regulation of protein homodimerization activity (GO:0090073)3.37204753
53negative regulation of calcium ion transport into cytosol (GO:0010523)3.34875397
54DNA deamination (GO:0045006)3.23607119
55protein K6-linked ubiquitination (GO:0085020)3.20901577
56histone H3-K36 demethylation (GO:0070544)3.18318946
57secretory granule organization (GO:0033363)3.17717773
58gonadal mesoderm development (GO:0007506)3.16411470
59protein neddylation (GO:0045116)3.10973891
60gamma-aminobutyric acid transport (GO:0015812)3.09657021
61ATP synthesis coupled proton transport (GO:0015986)3.09156886
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09156886
63nephron tubule morphogenesis (GO:0072078)3.08934641
64nephron epithelium morphogenesis (GO:0072088)3.08934641
65wound healing, spreading of epidermal cells (GO:0035313)3.08371053
66regulation of meiosis I (GO:0060631)3.06951572
67positive regulation of mast cell activation (GO:0033005)3.03871372
68carnitine shuttle (GO:0006853)3.03697184
69lysosome localization (GO:0032418)2.97753687
70negative regulation of epidermis development (GO:0045683)2.97744386
71regulation of chronic inflammatory response (GO:0002676)2.95478153
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94616156
73phenol-containing compound catabolic process (GO:0019336)2.92151053
74aromatic amino acid family catabolic process (GO:0009074)2.91461942
75parturition (GO:0007567)2.90499856
76retinal cone cell development (GO:0046549)2.88220685
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87499999
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.86786248
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86239226
80cellular response to exogenous dsRNA (GO:0071360)2.82441196
81regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.82296011
82chromosome organization involved in meiosis (GO:0070192)2.80505193
83positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78623938
84endothelium development (GO:0003158)2.77571274
85neurotransmitter catabolic process (GO:0042135)2.76732977
86arginine catabolic process (GO:0006527)2.75522561
87pathway-restricted SMAD protein phosphorylation (GO:0060389)2.74175185
88negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.71512284
89regulation of transcription regulatory region DNA binding (GO:2000677)2.68077167
90positive regulation of defense response to virus by host (GO:0002230)2.68050265
91positive regulation of guanylate cyclase activity (GO:0031284)2.65371300
92ncRNA catabolic process (GO:0034661)2.63008874
93piRNA metabolic process (GO:0034587)2.62726300
94positive regulation of sodium ion transmembrane transport (GO:1902307)2.62345508
95preassembly of GPI anchor in ER membrane (GO:0016254)2.60220027
96protein polyglutamylation (GO:0018095)2.55908909
97regulation of energy homeostasis (GO:2000505)2.53786323
98tryptophan metabolic process (GO:0006568)2.52345515
99regulation of interleukin-6 biosynthetic process (GO:0045408)2.51838781
100regulation of MHC class I biosynthetic process (GO:0045343)2.49729122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.22886386
2ZNF274_21170338_ChIP-Seq_K562_Hela4.42302268
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.94498393
4IRF1_19129219_ChIP-ChIP_H3396_Human2.69388509
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.67164641
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.61109687
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.58942179
8EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.17036036
9GBX2_23144817_ChIP-Seq_PC3_Human2.11624342
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.02818274
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02726254
12TP53_22573176_ChIP-Seq_HFKS_Human1.97582428
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91587316
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86110946
15NANOG_20526341_ChIP-Seq_ESCs_Human1.84025729
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72033903
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70896830
18FOXH1_21741376_ChIP-Seq_ESCs_Human1.68761908
19IGF1R_20145208_ChIP-Seq_DFB_Human1.66341072
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65039440
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64574892
22NANOG_19829295_ChIP-Seq_ESCs_Human1.62027909
23SOX2_19829295_ChIP-Seq_ESCs_Human1.62027909
24TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57178436
25ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54635289
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52575098
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51788810
28EWS_26573619_Chip-Seq_HEK293_Human1.51115177
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50753221
30TAF2_19829295_ChIP-Seq_ESCs_Human1.49899413
31VDR_22108803_ChIP-Seq_LS180_Human1.49003513
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48162489
33E2F1_20622854_ChIP-Seq_HELA_Human1.46807936
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.45682412
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44489543
36AR_20517297_ChIP-Seq_VCAP_Human1.43007460
37RAC3_21632823_ChIP-Seq_H3396_Human1.42921543
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.41716420
39ERA_21632823_ChIP-Seq_H3396_Human1.38387672
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.35919388
41FOXH1_21741376_ChIP-Seq_EPCs_Human1.34763413
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.34580318
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33343903
44FUS_26573619_Chip-Seq_HEK293_Human1.30762822
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29748785
46P53_21459846_ChIP-Seq_SAOS-2_Human1.29306571
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.28883697
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28099049
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27269225
50NCOR_22424771_ChIP-Seq_293T_Human1.26845876
51EGR1_19032775_ChIP-ChIP_M12_Human1.26391453
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24900072
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23603903
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16861060
55MYC_19829295_ChIP-Seq_ESCs_Human1.15810944
56GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14759621
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14697697
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.14489721
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13707056
60RNF2_27304074_Chip-Seq_NSC_Mouse1.12031033
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11544624
62HOXB7_26014856_ChIP-Seq_BT474_Human1.11251071
63GATA3_26560356_Chip-Seq_TH2_Human1.10826891
64MYC_18940864_ChIP-ChIP_HL60_Human1.10110005
65REST_21632747_ChIP-Seq_MESCs_Mouse1.09625820
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.08571788
67TCF4_23295773_ChIP-Seq_U87_Human1.07718286
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06896440
69JUN_21703547_ChIP-Seq_K562_Human1.06706913
70P300_27268052_Chip-Seq_Bcells_Human1.05317031
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04585698
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.04585698
73OCT4_20526341_ChIP-Seq_ESCs_Human1.04306852
74TCF4_22108803_ChIP-Seq_LS180_Human1.04143935
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03372686
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03283442
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02141977
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01832581
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01287352
80P300_19829295_ChIP-Seq_ESCs_Human1.00607346
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.00501484
82BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.00142910
83OCT1_27270436_Chip-Seq_PROSTATE_Human1.00016258
84NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96441344
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.95965049
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94901569
87PHF8_20622854_ChIP-Seq_HELA_Human0.94659298
88YY1_21170310_ChIP-Seq_MESCs_Mouse0.94541367
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.92249063
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.90780325
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.89455909
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89003849
93ER_23166858_ChIP-Seq_MCF-7_Human0.88924679
94CBP_20019798_ChIP-Seq_JUKART_Human0.88812137
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88812137
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86951438
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86435312
98VDR_23849224_ChIP-Seq_CD4+_Human0.86127842
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85790627
100SOX2_21211035_ChIP-Seq_LN229_Human0.85621851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.22700989
2MP0003646_muscle_fatigue5.24574865
3MP0002837_dystrophic_cardiac_calcinosis3.38713959
4MP0002160_abnormal_reproductive_system2.74485155
5MP0002163_abnormal_gland_morphology2.55112861
6MP0000372_irregular_coat_pigmentation2.50478226
7MP0005645_abnormal_hypothalamus_physiol2.44623345
8MP0008877_abnormal_DNA_methylation2.43120952
9MP0008872_abnormal_physiological_respon2.39628935
10MP0005167_abnormal_blood-brain_barrier2.38392060
11MP0002138_abnormal_hepatobiliary_system2.33553644
12MP0003329_amyloid_beta_deposits2.24569177
13MP0004043_abnormal_pH_regulation2.17387933
14MP0008875_abnormal_xenobiotic_pharmacok2.14747666
15MP0001919_abnormal_reproductive_system2.13216431
16MP0005389_reproductive_system_phenotype2.08029827
17MP0001440_abnormal_grooming_behavior1.93020371
18MP0006292_abnormal_olfactory_placode1.88823182
19MP0000604_amyloidosis1.86151138
20MP0001835_abnormal_antigen_presentation1.76034959
21MP0005551_abnormal_eye_electrophysiolog1.72750826
22MP0003195_calcinosis1.72504624
23MP0003136_yellow_coat_color1.71600643
24MP0000049_abnormal_middle_ear1.69711130
25MP0004381_abnormal_hair_follicle1.67364525
26MP0001873_stomach_inflammation1.66689801
27MP0006276_abnormal_autonomic_nervous1.60272388
28MP0005085_abnormal_gallbladder_physiolo1.53537267
29MP0004147_increased_porphyrin_level1.53048564
30MP0004145_abnormal_muscle_electrophysio1.52797603
31MP0004885_abnormal_endolymph1.52553596
32MP0005379_endocrine/exocrine_gland_phen1.50298251
33MP0001664_abnormal_digestion1.42404673
34MP0004858_abnormal_nervous_system1.39520548
35MP0002876_abnormal_thyroid_physiology1.34734056
36MP0005671_abnormal_response_to1.34570340
37MP0009745_abnormal_behavioral_response1.33604318
38MP0001986_abnormal_taste_sensitivity1.33153000
39MP0005410_abnormal_fertilization1.32933372
40MP0002102_abnormal_ear_morphology1.32544594
41MP0005075_abnormal_melanosome_morpholog1.30838263
42MP0009379_abnormal_foot_pigmentation1.30393790
43MP0005387_immune_system_phenotype1.29901556
44MP0001790_abnormal_immune_system1.29901556
45MP0008775_abnormal_heart_ventricle1.29786105
46MP0001968_abnormal_touch/_nociception1.23728136
47MP0003252_abnormal_bile_duct1.20545168
48MP0004130_abnormal_muscle_cell1.20448255
49MP0006036_abnormal_mitochondrial_physio1.17695070
50MP0005084_abnormal_gallbladder_morpholo1.16551320
51MP0002272_abnormal_nervous_system1.16275981
52MP0009764_decreased_sensitivity_to1.13605054
53MP0004142_abnormal_muscle_tone1.13231062
54MP0000685_abnormal_immune_system1.12545021
55MP0002234_abnormal_pharynx_morphology1.10552049
56MP0000427_abnormal_hair_cycle1.07963238
57MP0004084_abnormal_cardiac_muscle1.05582008
58MP0002733_abnormal_thermal_nociception1.05134117
59MP0002148_abnormal_hypersensitivity_rea1.01322527
60MP0002557_abnormal_social/conspecific_i1.00783612
61MP0003718_maternal_effect0.96342008
62MP0005266_abnormal_metabolism0.96266290
63MP0001501_abnormal_sleep_pattern0.95028185
64MP0000470_abnormal_stomach_morphology0.94374525
65MP0004742_abnormal_vestibular_system0.89364125
66MP0005195_abnormal_posterior_eye0.88694078
67MP0001663_abnormal_digestive_system0.88546016
68MP0002254_reproductive_system_inflammat0.87188189
69MP0009643_abnormal_urine_homeostasis0.86784615
70MP0001963_abnormal_hearing_physiology0.84931744
71MP0005408_hypopigmentation0.84222253
72MP0002139_abnormal_hepatobiliary_system0.83941900
73MP0005332_abnormal_amino_acid0.83690083
74MP0010329_abnormal_lipoprotein_level0.83274794
75MP0009046_muscle_twitch0.83170254
76MP0005646_abnormal_pituitary_gland0.79939329
77MP0001756_abnormal_urination0.78936929
78MP0001970_abnormal_pain_threshold0.77728010
79MP0004484_altered_response_of0.75703807
80MP0002572_abnormal_emotion/affect_behav0.72293943
81MP0002210_abnormal_sex_determination0.71643424
82MP0005365_abnormal_bile_salt0.71561126
83MP0002752_abnormal_somatic_nervous0.70153533
84MP0002095_abnormal_skin_pigmentation0.69377158
85MP0002932_abnormal_joint_morphology0.68567457
86MP0009333_abnormal_splenocyte_physiolog0.68190195
87MP0005360_urolithiasis0.65234482
88MP0003787_abnormal_imprinting0.65156284
89MP0001286_abnormal_eye_development0.64660405
90MP0002063_abnormal_learning/memory/cond0.63153557
91MP0003632_abnormal_nervous_system0.62394433
92MP0003693_abnormal_embryo_hatching0.62217650
93MP0005647_abnormal_sex_gland0.61979871
94MP0001348_abnormal_lacrimal_gland0.61845125
95MP0002938_white_spotting0.61415893
96MP0004233_abnormal_muscle_weight0.60152007
97MP0001764_abnormal_homeostasis0.59967579
98MP0003045_fibrosis0.59949335
99MP0003186_abnormal_redox_activity0.59818301
100MP0001800_abnormal_humoral_immune0.58817385

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)6.57143341
2Hypoplasia of the fovea (HP:0007750)6.57143341
3Bilateral microphthalmos (HP:0007633)6.21629049
4Unilateral renal agenesis (HP:0000122)6.19074795
5Conjugated hyperbilirubinemia (HP:0002908)5.42564495
6Abnormality of the fovea (HP:0000493)5.13178927
73-Methylglutaconic aciduria (HP:0003535)4.51062627
8Aplasia/Hypoplasia of the macula (HP:0008059)4.46132388
9Aplasia cutis congenita (HP:0001057)4.29354271
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.21658236
11Fused cervical vertebrae (HP:0002949)3.94141681
12Progressive inability to walk (HP:0002505)3.79715448
13Stomatitis (HP:0010280)3.64774019
14Congenital stationary night blindness (HP:0007642)3.60786455
15Abnormality of the right ventricle (HP:0001707)3.17646444
16Tubular atrophy (HP:0000092)3.09349236
17Lissencephaly (HP:0001339)3.02745256
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.99503210
19Inability to walk (HP:0002540)2.95194739
20Concave nail (HP:0001598)2.93039699
21Molar tooth sign on MRI (HP:0002419)2.82123436
22Abnormality of midbrain morphology (HP:0002418)2.82123436
23Type II lissencephaly (HP:0007260)2.80335656
24Abnormality of the parietal bone (HP:0002696)2.80137074
25Decreased central vision (HP:0007663)2.76942957
26Mixed hearing impairment (HP:0000410)2.72502606
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.63462986
28Abnormality of transition element cation homeostasis (HP:0011030)2.59580133
29Widely patent fontanelles and sutures (HP:0004492)2.58983107
30CNS hypomyelination (HP:0003429)2.55645385
31Increased hepatocellular lipid droplets (HP:0006565)2.54282378
32Lipid accumulation in hepatocytes (HP:0006561)2.51539793
33Acute necrotizing encephalopathy (HP:0006965)2.47719507
34Type 2 muscle fiber atrophy (HP:0003554)2.46877216
35Increased intramyocellular lipid droplets (HP:0012240)2.45441779
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43257620
37Hypoplasia of the uterus (HP:0000013)2.42236156
38Increased IgM level (HP:0003496)2.42197189
39Congenital, generalized hypertrichosis (HP:0004540)2.36427161
40Abnormality of T cell physiology (HP:0011840)2.34221306
41Nephronophthisis (HP:0000090)2.33424659
42Partial agenesis of the corpus callosum (HP:0001338)2.33396031
43Severe muscular hypotonia (HP:0006829)2.32661241
44Abnormal rod and cone electroretinograms (HP:0008323)2.32354976
45Abnormality of the renal cortex (HP:0011035)2.30597809
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.27097454
47Pancreatic cysts (HP:0001737)2.25894204
48Mitochondrial inheritance (HP:0001427)2.25841605
49Decreased circulating renin level (HP:0003351)2.24013019
50Acute encephalopathy (HP:0006846)2.23491325
51Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.21642507
52Abnormal drinking behavior (HP:0030082)2.21056020
53Polydipsia (HP:0001959)2.21056020
54Hyperglycinuria (HP:0003108)2.20138240
55Bulbous nose (HP:0000414)2.16313642
56Nephrogenic diabetes insipidus (HP:0009806)2.14108832
57Metabolic alkalosis (HP:0200114)2.12203919
58Increased muscle lipid content (HP:0009058)2.10752630
59Muscle fiber atrophy (HP:0100295)2.10345325
60Lower limb hyperreflexia (HP:0002395)2.08753536
61Aplasia/hypoplasia of the uterus (HP:0008684)2.08200769
62Posterior subcapsular cataract (HP:0007787)2.07914002
63Hip dysplasia (HP:0001385)2.04967317
64Myokymia (HP:0002411)2.04847234
65Increased CSF lactate (HP:0002490)2.03489589
66Cerebellar dysplasia (HP:0007033)2.02367435
67Hydroxyprolinuria (HP:0003080)2.02285946
68Abnormality of proline metabolism (HP:0010907)2.02285946
69Abnormality of the renal medulla (HP:0100957)2.01906328
70Pancreatic fibrosis (HP:0100732)2.01700740
71Cerebral palsy (HP:0100021)2.01645161
72Abnormal mitochondria in muscle tissue (HP:0008316)2.01315461
73Constricted visual fields (HP:0001133)1.99782283
74Bony spicule pigmentary retinopathy (HP:0007737)1.97445257
75Vertebral fusion (HP:0002948)1.96962734
76Progressive macrocephaly (HP:0004481)1.94971098
77Polyuria (HP:0000103)1.94932695
78Attenuation of retinal blood vessels (HP:0007843)1.94575869
79True hermaphroditism (HP:0010459)1.92570231
80Optic disc pallor (HP:0000543)1.87980777
81Hypoproteinemia (HP:0003075)1.87895888
82Renal Fanconi syndrome (HP:0001994)1.87238617
83Tubulointerstitial fibrosis (HP:0005576)1.86588278
84Ulnar deviation of the wrist (HP:0003049)1.84169575
85Abolished electroretinogram (ERG) (HP:0000550)1.79308992
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76323612
87Abnormality of the pons (HP:0007361)1.76225607
88Alkalosis (HP:0001948)1.73832929
89Abnormality of urine glucose concentration (HP:0011016)1.72337504
90Glycosuria (HP:0003076)1.72337504
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71029383
92Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67593603
93Retinal dysplasia (HP:0007973)1.67110578
94Hepatocellular necrosis (HP:0001404)1.61485081
95Hypomagnesemia (HP:0002917)1.60130409
96Gaze-evoked nystagmus (HP:0000640)1.60094953
97Congenital hepatic fibrosis (HP:0002612)1.57681716
98Abnormality of iron homeostasis (HP:0011031)1.57168684
99Pachygyria (HP:0001302)1.55921763
100Sensorimotor neuropathy (HP:0007141)1.55621018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.88282294
2TLK14.96786135
3PINK14.48572626
4BMPR24.01876248
5SIK22.84931759
6MAP4K22.65159658
7SIK32.54510665
8ADRBK22.44606144
9TIE12.26870210
10DAPK22.18125264
11MAPKAPK32.17141439
12TAOK31.79891577
13FRK1.79810465
14NEK21.67687131
15MAP3K111.60836684
16GRK11.57829802
17MAP3K121.57672862
18ERBB21.51112652
19SIK11.50899943
20NUAK11.49778573
21MAP3K71.46028011
22MAPKAPK51.42716433
23WNK41.41894469
24STK111.41697670
25MAP3K41.36205773
26WNK31.29230109
27NME11.27733059
28MAPK131.23581830
29PHKG21.22425258
30PHKG11.22425258
31DAPK11.17893753
32MAP2K71.16991552
33ACVR1B1.14479944
34TXK1.14219046
35KIT1.02058643
36BMPR1B0.98583382
37STK160.98339723
38DYRK20.97993485
39ZAK0.97561644
40VRK20.97271946
41BCR0.95953943
42OXSR10.92378080
43SYK0.90977222
44ICK0.90387471
45MST40.87003197
46TEC0.86177134
47BTK0.85929120
48STK38L0.85554685
49PRKCG0.79374744
50STK30.78250326
51BCKDK0.75511770
52ADRBK10.72727285
53RPS6KA60.71688018
54PLK40.68745456
55TAF10.68078302
56PIK3CA0.67802746
57TRPM70.65742165
58CAMK10.65428462
59MAP2K40.64850548
60MARK30.63884941
61PRKAA20.60340928
62ILK0.56403130
63PRKCI0.55960654
64RPS6KA50.52881131
65ITK0.51790114
66PRKAA10.50912502
67EIF2AK10.49903823
68EEF2K0.49428740
69PTK2B0.47198490
70GRK50.46510312
71CAMK40.44887338
72FLT30.43847447
73STK380.42507076
74GRK70.42359126
75VRK10.41963447
76PRKCA0.41152735
77PRKCQ0.40501826
78MAP4K10.40153181
79PRKCE0.39516234
80CAMK2A0.39484933
81PRKCZ0.38880814
82PRKACG0.38611551
83RPS6KL10.38046350
84RPS6KC10.38046350
85CDK190.37654003
86INSRR0.37044653
87IGF1R0.34563922
88PAK60.31073876
89MAP2K60.30697117
90STK390.30680067
91TRIM280.29681778
92ATR0.28505080
93PRKACA0.28220640
94CSNK1G30.28111641
95CSNK1G20.26038480
96CSNK1A10.25779843
97WNK10.24273480
98MAPK40.23963283
99CHEK20.23808059
100LYN0.23645933

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.79132318
2Olfactory transduction_Homo sapiens_hsa047403.37168387
3Allograft rejection_Homo sapiens_hsa053303.14944755
4Autoimmune thyroid disease_Homo sapiens_hsa053202.89193344
5Linoleic acid metabolism_Homo sapiens_hsa005912.73545505
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.73054754
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.45932340
8Oxidative phosphorylation_Homo sapiens_hsa001902.44599576
9Caffeine metabolism_Homo sapiens_hsa002322.41168974
10Type I diabetes mellitus_Homo sapiens_hsa049402.31231944
11Graft-versus-host disease_Homo sapiens_hsa053322.18262816
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95479253
13Parkinsons disease_Homo sapiens_hsa050121.84423853
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75795922
15Cardiac muscle contraction_Homo sapiens_hsa042601.66299977
16Ether lipid metabolism_Homo sapiens_hsa005651.64826810
17Ribosome_Homo sapiens_hsa030101.62193900
18Fatty acid elongation_Homo sapiens_hsa000621.61588377
19Phototransduction_Homo sapiens_hsa047441.60301269
20Selenocompound metabolism_Homo sapiens_hsa004501.59841804
21Alzheimers disease_Homo sapiens_hsa050101.53562610
22Arachidonic acid metabolism_Homo sapiens_hsa005901.50013725
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49042093
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36548916
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36127581
26Basal transcription factors_Homo sapiens_hsa030221.34607524
27Rheumatoid arthritis_Homo sapiens_hsa053231.27810313
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27657295
29Proteasome_Homo sapiens_hsa030501.26789995
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.25960840
31Nitrogen metabolism_Homo sapiens_hsa009101.25340848
32RNA degradation_Homo sapiens_hsa030181.20527845
33Huntingtons disease_Homo sapiens_hsa050161.18372537
34Fat digestion and absorption_Homo sapiens_hsa049751.14216877
35Chemical carcinogenesis_Homo sapiens_hsa052041.10537173
36Regulation of autophagy_Homo sapiens_hsa041401.08281242
37African trypanosomiasis_Homo sapiens_hsa051431.05719217
38Arginine and proline metabolism_Homo sapiens_hsa003301.05636144
39Tryptophan metabolism_Homo sapiens_hsa003801.02251828
40Histidine metabolism_Homo sapiens_hsa003401.02251447
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01462280
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98549511
43Morphine addiction_Homo sapiens_hsa050320.95885001
44Homologous recombination_Homo sapiens_hsa034400.93765105
45Butanoate metabolism_Homo sapiens_hsa006500.92425030
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92203825
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89847363
48Salivary secretion_Homo sapiens_hsa049700.87944753
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86488057
50Retinol metabolism_Homo sapiens_hsa008300.84789954
51Primary immunodeficiency_Homo sapiens_hsa053400.81209985
52Long-term depression_Homo sapiens_hsa047300.78557710
53Fanconi anemia pathway_Homo sapiens_hsa034600.77014194
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76724986
55Glutamatergic synapse_Homo sapiens_hsa047240.75522857
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.74917490
57Arginine biosynthesis_Homo sapiens_hsa002200.74854490
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74653755
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72409275
60Nicotine addiction_Homo sapiens_hsa050330.71846458
61GABAergic synapse_Homo sapiens_hsa047270.68252295
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67991475
63Circadian entrainment_Homo sapiens_hsa047130.67937337
64Gastric acid secretion_Homo sapiens_hsa049710.66800443
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.66537885
66Propanoate metabolism_Homo sapiens_hsa006400.66039263
67Collecting duct acid secretion_Homo sapiens_hsa049660.65684164
68Sulfur relay system_Homo sapiens_hsa041220.65093977
69Protein export_Homo sapiens_hsa030600.63424147
70RNA polymerase_Homo sapiens_hsa030200.61317943
71Vitamin digestion and absorption_Homo sapiens_hsa049770.60645833
72ABC transporters_Homo sapiens_hsa020100.60359667
73Staphylococcus aureus infection_Homo sapiens_hsa051500.60165272
74Viral myocarditis_Homo sapiens_hsa054160.58280219
75beta-Alanine metabolism_Homo sapiens_hsa004100.55046989
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54913911
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.54254444
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54225170
79Antigen processing and presentation_Homo sapiens_hsa046120.51534835
80Insulin secretion_Homo sapiens_hsa049110.51160233
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51088740
82Pyrimidine metabolism_Homo sapiens_hsa002400.50816684
83Serotonergic synapse_Homo sapiens_hsa047260.50647219
84Choline metabolism in cancer_Homo sapiens_hsa052310.50499574
85Peroxisome_Homo sapiens_hsa041460.50303840
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48929407
87Calcium signaling pathway_Homo sapiens_hsa040200.47371571
88TGF-beta signaling pathway_Homo sapiens_hsa043500.47029364
89Metabolic pathways_Homo sapiens_hsa011000.46130977
90Ovarian steroidogenesis_Homo sapiens_hsa049130.45516857
91Tyrosine metabolism_Homo sapiens_hsa003500.43949470
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42844309
93Oxytocin signaling pathway_Homo sapiens_hsa049210.41655183
94Vitamin B6 metabolism_Homo sapiens_hsa007500.41053140
95Taste transduction_Homo sapiens_hsa047420.39987152
96Circadian rhythm_Homo sapiens_hsa047100.39983917
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39093938
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.38933013
99Hematopoietic cell lineage_Homo sapiens_hsa046400.38705692
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38244312

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