RPLP0

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.57086671
2* viral transcription (GO:0019083)7.09968009
3* translational termination (GO:0006415)6.86017896
4ribosomal small subunit biogenesis (GO:0042274)6.11877970
5* translational elongation (GO:0006414)6.09845978
6maturation of SSU-rRNA (GO:0030490)5.89274266
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.84127326
8* protein targeting to ER (GO:0045047)5.69385999
9* cotranslational protein targeting to membrane (GO:0006613)5.68989807
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.52819824
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.42850569
12* translational initiation (GO:0006413)5.37242669
13* viral life cycle (GO:0019058)5.34370932
14* protein localization to endoplasmic reticulum (GO:0070972)5.32525341
15* cellular protein complex disassembly (GO:0043624)5.31821649
16ribosomal large subunit biogenesis (GO:0042273)4.86919968
17* protein complex disassembly (GO:0043241)4.76875943
18* macromolecular complex disassembly (GO:0032984)4.45673113
19formation of translation preinitiation complex (GO:0001731)4.37645506
20regulation of translational fidelity (GO:0006450)4.34338481
21DNA strand elongation involved in DNA replication (GO:0006271)4.34237735
22DNA unwinding involved in DNA replication (GO:0006268)4.32525402
23DNA deamination (GO:0045006)4.31978731
24mitotic chromosome condensation (GO:0007076)4.16702112
25* nuclear-transcribed mRNA catabolic process (GO:0000956)4.14413036
26DNA strand elongation (GO:0022616)4.13338145
27telomere maintenance via semi-conservative replication (GO:0032201)4.09959738
28* ribonucleoprotein complex biogenesis (GO:0022613)3.99790000
29* mRNA catabolic process (GO:0006402)3.93638355
30* translation (GO:0006412)3.85295607
31* RNA catabolic process (GO:0006401)3.77005666
32* protein targeting to membrane (GO:0006612)3.75770123
33DNA replication initiation (GO:0006270)3.70023997
34telomere maintenance via recombination (GO:0000722)3.57721412
35rRNA processing (GO:0006364)3.45494351
36nuclear pore complex assembly (GO:0051292)3.39111709
37establishment of viral latency (GO:0019043)3.38391472
38mitotic recombination (GO:0006312)3.37202442
39mitotic sister chromatid segregation (GO:0000070)3.34642024
40rRNA metabolic process (GO:0016072)3.33417459
41nucleobase biosynthetic process (GO:0046112)3.32376165
42folic acid-containing compound biosynthetic process (GO:0009396)3.30835642
43protein localization to kinetochore (GO:0034501)3.25102231
44telomere maintenance via telomere lengthening (GO:0010833)3.22062763
45IMP biosynthetic process (GO:0006188)3.16088055
46sister chromatid segregation (GO:0000819)3.13132051
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.12466722
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11981178
49negative regulation of RNA splicing (GO:0033119)3.09362342
50nuclear pore organization (GO:0006999)3.07611183
51DNA topological change (GO:0006265)3.05697740
52mitotic nuclear envelope disassembly (GO:0007077)3.00201664
53DNA replication checkpoint (GO:0000076)2.99752786
54ncRNA 3-end processing (GO:0043628)2.99413145
55DNA ligation (GO:0006266)2.96686514
56purine nucleobase biosynthetic process (GO:0009113)2.93160542
57DNA synthesis involved in DNA repair (GO:0000731)2.91989191
58spliceosomal snRNP assembly (GO:0000387)2.89858003
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89720983
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89720983
61* ribosome biogenesis (GO:0042254)2.88911106
62proline biosynthetic process (GO:0006561)2.88570496
63heterochromatin organization (GO:0070828)2.88544681
64regulation of mitochondrial translation (GO:0070129)2.88474363
65* protein targeting (GO:0006605)2.87886493
66protein localization to chromosome, centromeric region (GO:0071459)2.87092812
67* cellular component biogenesis (GO:0044085)2.86320826
68IMP metabolic process (GO:0046040)2.84913397
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83015494
70pseudouridine synthesis (GO:0001522)2.82734431
71negative regulation of DNA repair (GO:0045738)2.82473758
72nucleobase-containing small molecule interconversion (GO:0015949)2.81235455
73ribosome assembly (GO:0042255)2.77378096
74tRNA aminoacylation for protein translation (GO:0006418)2.77243313
75base-excision repair (GO:0006284)2.77196315
76metaphase plate congression (GO:0051310)2.76954386
77CENP-A containing nucleosome assembly (GO:0034080)2.76797339
78nuclear envelope disassembly (GO:0051081)2.75586400
79membrane disassembly (GO:0030397)2.75586400
80establishment of integrated proviral latency (GO:0075713)2.75428959
81L-serine metabolic process (GO:0006563)2.74816415
82DNA replication-dependent nucleosome assembly (GO:0006335)2.73857281
83DNA replication-dependent nucleosome organization (GO:0034723)2.73857281
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73839199
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.73484506
86mitotic sister chromatid cohesion (GO:0007064)2.73456380
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72690053
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71908199
89chromatin remodeling at centromere (GO:0031055)2.69797405
90amino acid activation (GO:0043038)2.69693589
91tRNA aminoacylation (GO:0043039)2.69693589
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64609355
93ATP synthesis coupled proton transport (GO:0015986)2.64609355
94DNA replication-independent nucleosome organization (GO:0034724)2.64607970
95DNA replication-independent nucleosome assembly (GO:0006336)2.64607970
96peptidyl-arginine omega-N-methylation (GO:0035247)2.63762466
97transcription-coupled nucleotide-excision repair (GO:0006283)2.60561680
98rRNA modification (GO:0000154)2.59338029
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58468794
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57394508
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56846703
102mRNA splicing, via spliceosome (GO:0000398)2.56846703
103RNA splicing, via transesterification reactions (GO:0000375)2.55863179
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54350750
105DNA duplex unwinding (GO:0032508)2.53841673
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52653651
107negative regulation of ligase activity (GO:0051352)2.52653651
108ncRNA processing (GO:0034470)2.52564138
109antigen processing and presentation of endogenous antigen (GO:0019883)2.51993667
110mitotic metaphase plate congression (GO:0007080)2.51576182
111translesion synthesis (GO:0019985)2.51282602
112DNA geometric change (GO:0032392)2.50915014
113proteasome assembly (GO:0043248)2.50878719
114regulation of protein heterodimerization activity (GO:0043497)2.50778527
115spliceosomal complex assembly (GO:0000245)2.49425122
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48987475
117* establishment of protein localization to membrane (GO:0090150)2.48664246
118telomere organization (GO:0032200)2.48313263
119telomere maintenance (GO:0000723)2.47864265
120termination of RNA polymerase II transcription (GO:0006369)2.44986166
121T cell apoptotic process (GO:0070231)2.44318859
122viral mRNA export from host cell nucleus (GO:0046784)2.42981446
123cell cycle G1/S phase transition (GO:0044843)2.42963030
124G1/S transition of mitotic cell cycle (GO:0000082)2.42963030
125* establishment of protein localization to organelle (GO:0072594)2.41023393
126* gene expression (GO:0010467)2.40165230
127DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.39022904
128ribonucleoprotein complex assembly (GO:0022618)2.38407361
129histone mRNA metabolic process (GO:0008334)2.38230769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08312521
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19836775
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05272488
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.01831045
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96959747
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88589612
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.73399382
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.69321141
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66960565
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62406745
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59898749
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57850488
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53937731
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45730308
15* XRN2_22483619_ChIP-Seq_HELA_Human2.44677998
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43476031
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36661166
18MYC_22102868_ChIP-Seq_BL_Human2.35672514
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31995456
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28403237
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20291244
22* VDR_23849224_ChIP-Seq_CD4+_Human2.15047872
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08802188
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04409602
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.03516156
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99736319
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.93904438
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89046529
29* TTF2_22483619_ChIP-Seq_HELA_Human1.83393900
30* DCP1A_22483619_ChIP-Seq_HELA_Human1.83303290
31CIITA_25753668_ChIP-Seq_RAJI_Human1.78252869
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78018095
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76038593
34* VDR_21846776_ChIP-Seq_THP-1_Human1.75966276
35GABP_19822575_ChIP-Seq_HepG2_Human1.74039528
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69214203
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67687297
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.59690404
39ZNF263_19887448_ChIP-Seq_K562_Human1.56643746
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56079670
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55439157
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54831910
43ELK1_19687146_ChIP-ChIP_HELA_Human1.54369748
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53038676
45AR_21909140_ChIP-Seq_LNCAP_Human1.52488141
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52431751
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51568486
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49769160
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49505511
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47991111
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46195883
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44840960
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.42882977
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42047252
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39593771
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38955993
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38635876
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35860866
59SPI1_23547873_ChIP-Seq_NB4_Human1.34267911
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33386866
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31622615
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31328669
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30601908
64KDM5A_27292631_Chip-Seq_BREAST_Human1.30304289
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28885575
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26871099
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.26159721
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.25062824
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24292380
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23395870
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21279415
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.20443889
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19519335
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19276258
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18310560
76* MAF_26560356_Chip-Seq_TH1_Human1.18075670
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18017950
78UTX_26944678_Chip-Seq_JUKART_Human1.17773103
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17341473
80SCL_19346495_ChIP-Seq_HPC-7_Human1.17254284
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.16676478
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16168619
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13541028
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13321036
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12963964
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12318390
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10254880
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10195222
89* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10052750
90TFEB_21752829_ChIP-Seq_HELA_Human1.09507919
91MYB_26560356_Chip-Seq_TH2_Human1.08664727
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07996336
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04909624
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02691957
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02465265
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01648676
97MAF_26560356_Chip-Seq_TH2_Human1.01496809
98MYB_26560356_Chip-Seq_TH1_Human1.01182048
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.00973560
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00555121
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99718913
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.98693706
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97279153
104MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97192419
105VDR_24763502_ChIP-Seq_THP-1_Human0.97167039
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.95449218
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95140148
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94596573
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94419782
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.92917071
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.92755183
112MYC_18940864_ChIP-ChIP_HL60_Human0.91079039
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91002130
114CHD1_26751641_Chip-Seq_LNCaP_Human0.90988634
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90583688
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88623075
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88594719
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88235708
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88048537
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.87625156
121TCF7_22412390_ChIP-Seq_EML_Mouse0.87554512
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87490749
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87016216
124FOXP1_21924763_ChIP-Seq_HESCs_Human0.84646417
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84398269
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83893451
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83671914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.09640356
2MP0004957_abnormal_blastocyst_morpholog3.38123453
3MP0010094_abnormal_chromosome_stability3.24487451
4MP0003111_abnormal_nucleus_morphology3.15754871
5MP0003077_abnormal_cell_cycle3.12057055
6MP0002396_abnormal_hematopoietic_system3.11534763
7MP0003763_abnormal_thymus_physiology2.59223660
8MP0009379_abnormal_foot_pigmentation2.50889576
9MP0008007_abnormal_cellular_replicative2.43063399
10MP0008057_abnormal_DNA_replication2.41828215
11MP0008058_abnormal_DNA_repair2.26643332
12MP0004808_abnormal_hematopoietic_stem2.19227211
13MP0009333_abnormal_splenocyte_physiolog2.14000619
14MP0000490_abnormal_crypts_of2.11158293
15MP0010352_gastrointestinal_tract_polyps2.10747544
16MP0000685_abnormal_immune_system1.99124786
17MP0001835_abnormal_antigen_presentation1.90407869
18MP0002398_abnormal_bone_marrow1.88446187
19MP0008932_abnormal_embryonic_tissue1.82834798
20MP0005397_hematopoietic_system_phenotyp1.72032232
21MP0001545_abnormal_hematopoietic_system1.72032232
22MP0000703_abnormal_thymus_morphology1.71659474
23MP0001730_embryonic_growth_arrest1.71446633
24MP0000350_abnormal_cell_proliferation1.70600333
25MP0000566_synostosis1.67678827
26MP0002722_abnormal_immune_system1.66913969
27MP0005671_abnormal_response_to1.63626286
28MP0006054_spinal_hemorrhage1.61556411
29MP0001800_abnormal_humoral_immune1.60323639
30MP0009697_abnormal_copulation1.59252553
31MP0003718_maternal_effect1.56695635
32MP0000689_abnormal_spleen_morphology1.56439323
33MP0006292_abnormal_olfactory_placode1.54591190
34MP0009672_abnormal_birth_weight1.53640169
35MP0002019_abnormal_tumor_incidence1.52327083
36MP0003786_premature_aging1.48800338
37MP0003806_abnormal_nucleotide_metabolis1.46904614
38MP0002420_abnormal_adaptive_immunity1.46846434
39MP0002429_abnormal_blood_cell1.45748106
40MP0000716_abnormal_immune_system1.45297391
41MP0001346_abnormal_lacrimal_gland1.44541815
42MP0001819_abnormal_immune_cell1.44445203
43MP0002166_altered_tumor_susceptibility1.44065305
44MP0002938_white_spotting1.43070965
45MP0003436_decreased_susceptibility_to1.41538546
46MP0002452_abnormal_antigen_presenting1.41464443
47MP0002697_abnormal_eye_size1.39226624
48MP0010307_abnormal_tumor_latency1.39225249
49MP0009785_altered_susceptibility_to1.38524638
50MP0003941_abnormal_skin_development1.34638225
51MP0002723_abnormal_immune_serum1.34286727
52MP0002796_impaired_skin_barrier1.34115479
53MP0000313_abnormal_cell_death1.32908804
54MP0003123_paternal_imprinting1.31944966
55MP0002405_respiratory_system_inflammati1.30329730
56MP0010155_abnormal_intestine_physiology1.29613128
57MP0000465_gastrointestinal_hemorrhage1.29587347
58MP0000858_altered_metastatic_potential1.28774015
59MP0001873_stomach_inflammation1.28096303
60MP0008995_early_reproductive_senescence1.26818086
61MP0005000_abnormal_immune_tolerance1.26644877
62MP0001853_heart_inflammation1.26225657
63MP0004185_abnormal_adipocyte_glucose1.25472305
64MP0005025_abnormal_response_to1.25170420
65MP0002080_prenatal_lethality1.22951759
66MP0003866_abnormal_defecation1.22109499
67MP0005174_abnormal_tail_pigmentation1.21715437
68MP0002132_abnormal_respiratory_system1.21239128
69MP0001697_abnormal_embryo_size1.21028537
70MP0009278_abnormal_bone_marrow1.18786861
71MP0006035_abnormal_mitochondrial_morpho1.16593401
72MP0003937_abnormal_limbs/digits/tail_de1.15914974
73MP0002006_tumorigenesis1.15493279
74MP0001145_abnormal_male_reproductive1.12036606
75MP0003136_yellow_coat_color1.09253816
76MP0005380_embryogenesis_phenotype1.08884339
77MP0001672_abnormal_embryogenesis/_devel1.08884339
78MP0003567_abnormal_fetal_cardiomyocyte1.08287590
79MP0001790_abnormal_immune_system1.07703482
80MP0005387_immune_system_phenotype1.07703482
81MP0010234_abnormal_vibrissa_follicle1.07105342
82MP0001286_abnormal_eye_development1.06916829
83MP0005464_abnormal_platelet_physiology1.06884724
84MP0005023_abnormal_wound_healing1.06298823
85MP0001929_abnormal_gametogenesis1.05991728
86MP0009053_abnormal_anal_canal1.04421899
87MP0003984_embryonic_growth_retardation1.04130613
88MP0002088_abnormal_embryonic_growth/wei1.01937957
89MP0005075_abnormal_melanosome_morpholog1.01875907
90MP0002095_abnormal_skin_pigmentation0.98342882
91MP0002111_abnormal_tail_morphology0.98204012
92MP0000762_abnormal_tongue_morphology0.97678955
93MP0004197_abnormal_fetal_growth/weight/0.97522787
94MP0004947_skin_inflammation0.97396368
95MP0002086_abnormal_extraembryonic_tissu0.97375287
96MP0001661_extended_life_span0.97083097
97MP0000653_abnormal_sex_gland0.96143304
98MP0002148_abnormal_hypersensitivity_rea0.95575001
99MP0002092_abnormal_eye_morphology0.93788339
100MP0002085_abnormal_embryonic_tissue0.93344880
101MP0002009_preneoplasia0.91890801
102MP0001881_abnormal_mammary_gland0.91467316
103MP0003890_abnormal_embryonic-extraembry0.89207023
104MP0004233_abnormal_muscle_weight0.88529904
105MP0002877_abnormal_melanocyte_morpholog0.88350104
106MP0000477_abnormal_intestine_morphology0.86883671
107MP0002084_abnormal_developmental_patter0.86856202
108MP0005076_abnormal_cell_differentiation0.85650296
109MP0005501_abnormal_skin_physiology0.84605833
110MP0005451_abnormal_body_composition0.84564512
111MP0000428_abnormal_craniofacial_morphol0.84317787
112MP0002160_abnormal_reproductive_system0.84246618
113MP0003300_gastrointestinal_ulcer0.83052094
114MP0004264_abnormal_extraembryonic_tissu0.82610417
115MP0005408_hypopigmentation0.82315880
116MP0009703_decreased_birth_body0.81226456
117MP0001845_abnormal_inflammatory_respons0.80529063
118MP0002933_joint_inflammation0.80149493
119MP0010030_abnormal_orbit_morphology0.79661424
120MP0002233_abnormal_nose_morphology0.79558616
121MP0000678_abnormal_parathyroid_gland0.79553079
122MP0000462_abnormal_digestive_system0.79157968
123MP0000537_abnormal_urethra_morphology0.78606219
124MP0003315_abnormal_perineum_morphology0.76603136
125MP0000049_abnormal_middle_ear0.75304905
126MP0002419_abnormal_innate_immunity0.74505496
127MP0000358_abnormal_cell_content/0.74231347
128MP0003385_abnormal_body_wall0.72377075
129MP0002249_abnormal_larynx_morphology0.70924029
130MP0002163_abnormal_gland_morphology0.70918693
131MP0002098_abnormal_vibrissa_morphology0.70101410
132MP0003935_abnormal_craniofacial_develop0.69945381
133MP0006036_abnormal_mitochondrial_physio0.69587173
134MP0002234_abnormal_pharynx_morphology0.69465440
135MP0003724_increased_susceptibility_to0.69330382
136MP0003448_altered_tumor_morphology0.69283925
137MP0001849_ear_inflammation0.68740718
138MP0000627_abnormal_mammary_gland0.68546617
139MP0003699_abnormal_female_reproductive0.67507547
140MP0003303_peritoneal_inflammation0.66922281
141MP0001293_anophthalmia0.66703193
142MP0008877_abnormal_DNA_methylation0.66650063
143MP0001119_abnormal_female_reproductive0.66276726
144MP0001340_abnormal_eyelid_morphology0.66209049
145MP0008789_abnormal_olfactory_epithelium0.65596982
146MP0001216_abnormal_epidermal_layer0.63668597
147MP0003566_abnormal_cell_adhesion0.63139169
148MP0003186_abnormal_redox_activity0.62594924
149MP0001243_abnormal_dermal_layer0.61708272
150MP0009931_abnormal_skin_appearance0.60422811
151MP0003705_abnormal_hypodermis_morpholog0.58391584
152MP0003943_abnormal_hepatobiliary_system0.57898058
153MP0002060_abnormal_skin_morphology0.56812697
154MP0002210_abnormal_sex_determination0.56297564

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.70081401
2Reticulocytopenia (HP:0001896)6.47772941
3Abnormal number of erythroid precursors (HP:0012131)6.27827375
4Thrombocytosis (HP:0001894)4.51960772
5Macrocytic anemia (HP:0001972)4.41112333
6Pallor (HP:0000980)4.40611634
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.37126614
8Colon cancer (HP:0003003)3.77465056
9Microvesicular hepatic steatosis (HP:0001414)3.74792212
10Aplastic anemia (HP:0001915)3.53148219
11IgM deficiency (HP:0002850)3.23689874
1211 pairs of ribs (HP:0000878)3.11154777
13Oral leukoplakia (HP:0002745)2.98016139
14Elevated erythrocyte sedimentation rate (HP:0003565)2.95872167
15Birth length less than 3rd percentile (HP:0003561)2.92608001
16Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78731734
17Selective tooth agenesis (HP:0001592)2.75422816
18Chronic otitis media (HP:0000389)2.75150588
19Trismus (HP:0000211)2.63848655
20Increased hepatocellular lipid droplets (HP:0006565)2.59521313
21Multiple enchondromatosis (HP:0005701)2.57920934
22Absent thumb (HP:0009777)2.56743082
23Duplication of thumb phalanx (HP:0009942)2.54397240
24Microretrognathia (HP:0000308)2.52759999
25Basal cell carcinoma (HP:0002671)2.51290567
26Abnormality of T cells (HP:0002843)2.45545346
27Myelodysplasia (HP:0002863)2.44807324
28Rough bone trabeculation (HP:0100670)2.43741950
29Recurrent bronchitis (HP:0002837)2.42179341
30Abnormality of reticulocytes (HP:0004312)2.41900495
31Abnormality of T cell physiology (HP:0011840)2.39988785
32Progressive muscle weakness (HP:0003323)2.39684999
33Petechiae (HP:0000967)2.39122527
34Horseshoe kidney (HP:0000085)2.34129972
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.30347928
36Increased nuchal translucency (HP:0010880)2.28936013
37Abnormality of glycolysis (HP:0004366)2.24915270
38Lymphoma (HP:0002665)2.23805964
39Lipid accumulation in hepatocytes (HP:0006561)2.22251585
40Poikiloderma (HP:0001029)2.21184570
41Neoplasm of the pancreas (HP:0002894)2.21125475
42Panhypogammaglobulinemia (HP:0003139)2.19489270
43Degeneration of anterior horn cells (HP:0002398)2.17682230
44Abnormality of the anterior horn cell (HP:0006802)2.17682230
45T lymphocytopenia (HP:0005403)2.17281151
46Partial duplication of thumb phalanx (HP:0009944)2.15025909
47Breast hypoplasia (HP:0003187)2.14729745
48High anterior hairline (HP:0009890)2.14040117
49Small intestinal stenosis (HP:0012848)2.12461982
50Duodenal stenosis (HP:0100867)2.12461982
51Recurrent viral infections (HP:0004429)2.11966711
52Carpal bone hypoplasia (HP:0001498)2.08210148
53Respiratory difficulties (HP:0002880)2.06610787
54Premature graying of hair (HP:0002216)2.06331377
55Broad distal phalanx of finger (HP:0009836)2.04602742
56Abnormality of DNA repair (HP:0003254)2.04468239
57Abnormality of T cell number (HP:0011839)2.02016290
58Acute encephalopathy (HP:0006846)2.01546977
59Amaurosis fugax (HP:0100576)2.00730705
60Abnormal lung lobation (HP:0002101)1.99184120
61Glossoptosis (HP:0000162)1.99135766
62Myositis (HP:0100614)1.98887076
63Partial duplication of the phalanx of hand (HP:0009999)1.98612899
64Depressed nasal ridge (HP:0000457)1.98522935
65Progressive external ophthalmoplegia (HP:0000590)1.97911436
66Abnormal mitochondria in muscle tissue (HP:0008316)1.97762407
67Patellar aplasia (HP:0006443)1.97228921
68IgG deficiency (HP:0004315)1.96067656
69Pancytopenia (HP:0001876)1.95727141
70Increased serum pyruvate (HP:0003542)1.95451625
71Acute necrotizing encephalopathy (HP:0006965)1.94902287
72Abnormality of the preputium (HP:0100587)1.94841602
73Facial cleft (HP:0002006)1.93951073
74Asplenia (HP:0001746)1.91448620
75Abnormality of cells of the lymphoid lineage (HP:0012140)1.91427262
76Cellular immunodeficiency (HP:0005374)1.89956868
77Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86824197
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86824197
79Entropion (HP:0000621)1.86373239
80Nasal polyposis (HP:0100582)1.86089487
81Aplasia/Hypoplasia of the patella (HP:0006498)1.85761353
82Medulloblastoma (HP:0002885)1.85285005
83Abnormality of the carotid arteries (HP:0005344)1.84718368
84Lymphopenia (HP:0001888)1.84689215
85Nephroblastoma (Wilms tumor) (HP:0002667)1.84403566
86Abnormality of B cell number (HP:0010975)1.82865553
87B lymphocytopenia (HP:0010976)1.82865553
88Squamous cell carcinoma (HP:0002860)1.82805033
89Increased serum lactate (HP:0002151)1.82722499
90Stenosis of the external auditory canal (HP:0000402)1.82445119
91Hepatocellular necrosis (HP:0001404)1.82143080
92Bone marrow hypocellularity (HP:0005528)1.82086366
93Increased CSF lactate (HP:0002490)1.81967315
94Cleft eyelid (HP:0000625)1.81795679
95Missing ribs (HP:0000921)1.81682889
96Abnormality of cochlea (HP:0000375)1.80539264
97Abnormality of the duodenum (HP:0002246)1.80306573
98Duplicated collecting system (HP:0000081)1.79256644
99Thick lower lip vermilion (HP:0000179)1.78881780
100Chromsome breakage (HP:0040012)1.78618414
101Cellulitis (HP:0100658)1.78548490
102Meckel diverticulum (HP:0002245)1.78176920
103Microglossia (HP:0000171)1.77206543
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.76968019
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.76081194
106Cholecystitis (HP:0001082)1.75896530
107Abnormal gallbladder physiology (HP:0012438)1.75896530
108Abnormality of the heme biosynthetic pathway (HP:0010472)1.75502104
109Agnosia (HP:0010524)1.74887117
110Increased density of long bones (HP:0006392)1.74837178
111Atresia of the external auditory canal (HP:0000413)1.74171673
112Aplasia/Hypoplasia of the thymus (HP:0010515)1.74067750
113Abnormality of methionine metabolism (HP:0010901)1.73827502
114Muscle fiber atrophy (HP:0100295)1.73600717
115Abnormal hemoglobin (HP:0011902)1.73438630
116Abnormal number of incisors (HP:0011064)1.72707783
117Optic nerve coloboma (HP:0000588)1.72447123
118Triphalangeal thumb (HP:0001199)1.72298857
119Abnormality of the nasal mucosa (HP:0000433)1.71836022
120Mitochondrial inheritance (HP:0001427)1.71784698
121Pustule (HP:0200039)1.71140836
122Choanal atresia (HP:0000453)1.70816642
123Combined immunodeficiency (HP:0005387)1.70221370
124Abnormality of the ileum (HP:0001549)1.69817358
125Abnormality of chromosome stability (HP:0003220)1.69564092
126Recurrent fungal infections (HP:0002841)1.69500424
127Reduced antithrombin III activity (HP:0001976)1.69058386
128Cerebral edema (HP:0002181)1.68365905
129Abnormality of the parietal bone (HP:0002696)1.67613320
130Slender long bone (HP:0003100)1.67180378
131Gastrointestinal inflammation (HP:0004386)1.67096092
132Severe combined immunodeficiency (HP:0004430)1.67063072
133Type I transferrin isoform profile (HP:0003642)1.66433436
134Absent radius (HP:0003974)1.66408460
135Hypoplasia of the radius (HP:0002984)1.66081676
136Hypoplastic pelvis (HP:0008839)1.65652659
137Abnormal trabecular bone morphology (HP:0100671)1.65491019
138Prolonged bleeding time (HP:0003010)1.64669925
139Embryonal renal neoplasm (HP:0011794)1.64421868
140Acute lymphatic leukemia (HP:0006721)1.63571140
141Abnormality of the calcaneus (HP:0008364)1.63396849
142Tracheoesophageal fistula (HP:0002575)1.62916955
143Migraine (HP:0002076)1.62906252
144Proximal placement of thumb (HP:0009623)1.62725718
145Testicular atrophy (HP:0000029)1.62328395
146Hepatic necrosis (HP:0002605)1.62040390
147Short thumb (HP:0009778)1.61275028
148Granulocytopenia (HP:0001913)1.61145247
149Premature ovarian failure (HP:0008209)1.60879334
150Abnormality of the renal collecting system (HP:0004742)1.60465897
151Increased intramyocellular lipid droplets (HP:0012240)1.59598153
152Ectopic kidney (HP:0000086)1.58122577
153Lactic acidosis (HP:0003128)1.58050160
154Ependymoma (HP:0002888)1.57974248
155Deviation of the thumb (HP:0009603)1.57875364
156Neoplasm of the colon (HP:0100273)1.57494484
157Absent forearm bone (HP:0003953)1.54492615
158Aplasia involving forearm bones (HP:0009822)1.54492615
159Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.53128680
160Secondary amenorrhea (HP:0000869)1.52767161
161Premature skin wrinkling (HP:0100678)1.52699506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.28187632
2NME23.67629555
3EEF2K3.63185666
4BUB13.47981877
5PBK2.94190435
6WEE12.92978145
7MAP4K12.90622648
8SMG12.82144169
9CDC72.63202555
10EIF2AK12.29107422
11PASK2.28353666
12SRPK12.08497075
13TGFBR12.07046805
14RPS6KB22.06738630
15NEK22.03294160
16PKN22.00335615
17TAF11.99429260
18MAP3K101.95161453
19RPS6KA41.94316617
20TESK21.89844045
21TLK11.87498927
22LRRK21.85881716
23PIM21.73690571
24FLT31.70050853
25STK161.66845084
26TSSK61.63463040
27NME11.60802616
28STK101.57539744
29DYRK31.56384459
30ZAP701.54071418
31SCYL21.53756938
32VRK11.47802640
33TRIB31.40623989
34ACVR1B1.40101480
35ZAK1.39476131
36BTK1.33456909
37KDR1.33388821
38AURKB1.32764243
39EIF2AK31.29947956
40CDK71.28232232
41BRSK21.25440357
42PAK41.20232552
43MAP2K31.20211664
44ATR1.20122952
45JAK31.17881227
46MAP3K81.16282018
47CDK41.11185455
48PLK11.11035317
49BLK1.10618138
50BRAF1.10452089
51IRAK31.08392945
52MKNK11.05363855
53PIM11.04164100
54TXK1.02564208
55TEC1.01925221
56TTK1.00809527
57KIT1.00237581
58TYK20.99071206
59MAP3K110.94585514
60PLK40.94042002
61ARAF0.92023530
62ILK0.91332851
63PRPF4B0.88065107
64STK40.86791042
65MAPKAPK30.85448413
66ICK0.85290290
67GRK60.84191013
68ERN10.81357890
69TESK10.81307611
70TBK10.81204441
71CSF1R0.80980195
72AURKA0.75606912
73IKBKB0.74111860
74CHEK10.71445100
75NEK10.69172365
76MST40.68130981
77BRSK10.66243321
78CLK10.65959128
79SYK0.64320894
80ITK0.63327571
81NLK0.62224345
82EIF2AK20.61668699
83MAP3K30.60796890
84CHEK20.60239675
85LCK0.59271262
86CDK190.58250296
87RPS6KA50.57475425
88LATS20.54823104
89PRKCI0.52462731
90PAK10.52285709
91* CSNK2A20.51115594
92AKT20.50638554
93IRAK40.50394592
94CDK10.49627538
95MST1R0.49388748
96RAF10.48585974
97LYN0.48518351
98CDK60.47873872
99IKBKE0.47860362
100STK30.46480902
101ALK0.45999458
102CSNK2A10.45857465
103CDK80.45631270
104CDK20.45388829
105PNCK0.45184832
106PAK20.44217683
107CCNB10.44202685
108BCKDK0.44031271
109EPHA20.43642612
110ATM0.43100041
111CDK90.42963364
112DAPK10.41911407
113MUSK0.41762662
114STK240.40957101
115MKNK20.39173868
116DAPK30.38998389
117PLK30.38852744
118SIK10.37299943
119NEK90.37119222
120CDK120.36989561
121MTOR0.36912614
122MAP2K60.36644444
123MAPKAPK20.36557479
124TAOK20.35905256
125CHUK0.35560361
126RPS6KL10.35509951
127RPS6KC10.35509951
128MET0.35226766
129FGFR40.34684772
130BMX0.34531097
131RPS6KB10.34344569
132MAP2K20.34325613
133NUAK10.33595420
134BRD40.31506732
135ERBB40.30798143
136IRAK20.30223780
137PTK60.30019613

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.53947582
2DNA replication_Homo sapiens_hsa030304.54045731
3Mismatch repair_Homo sapiens_hsa034303.58706728
4Spliceosome_Homo sapiens_hsa030402.99629545
5Proteasome_Homo sapiens_hsa030502.89165439
6Base excision repair_Homo sapiens_hsa034102.81970208
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77000804
8RNA polymerase_Homo sapiens_hsa030202.73707779
9Homologous recombination_Homo sapiens_hsa034402.46001234
10Nucleotide excision repair_Homo sapiens_hsa034202.45668316
11RNA transport_Homo sapiens_hsa030132.43254769
12Pyrimidine metabolism_Homo sapiens_hsa002402.26872336
13One carbon pool by folate_Homo sapiens_hsa006702.19432319
14Cell cycle_Homo sapiens_hsa041102.07280870
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03696968
16Primary immunodeficiency_Homo sapiens_hsa053401.80755173
17Non-homologous end-joining_Homo sapiens_hsa034501.70186852
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65658872
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57241615
20Fanconi anemia pathway_Homo sapiens_hsa034601.56054698
21RNA degradation_Homo sapiens_hsa030181.55979147
22Antigen processing and presentation_Homo sapiens_hsa046121.49677426
23Oxidative phosphorylation_Homo sapiens_hsa001901.48439157
24p53 signaling pathway_Homo sapiens_hsa041151.46332395
25Carbon metabolism_Homo sapiens_hsa012001.34959449
26Basal transcription factors_Homo sapiens_hsa030221.28278169
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27782157
28Herpes simplex infection_Homo sapiens_hsa051681.25550154
29mRNA surveillance pathway_Homo sapiens_hsa030151.23720310
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22331703
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15177597
32Systemic lupus erythematosus_Homo sapiens_hsa053221.08781363
33Pyruvate metabolism_Homo sapiens_hsa006201.06856827
34Purine metabolism_Homo sapiens_hsa002301.05811441
35Protein export_Homo sapiens_hsa030601.03489266
36Viral carcinogenesis_Homo sapiens_hsa052031.00097867
37Measles_Homo sapiens_hsa051620.99743397
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.98102322
39Sulfur relay system_Homo sapiens_hsa041220.96277392
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95959457
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.94968325
42Legionellosis_Homo sapiens_hsa051340.92153306
43HTLV-I infection_Homo sapiens_hsa051660.91935586
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89010619
45Pentose phosphate pathway_Homo sapiens_hsa000300.88503442
46Vitamin B6 metabolism_Homo sapiens_hsa007500.86326315
47Hematopoietic cell lineage_Homo sapiens_hsa046400.80555866
48Fructose and mannose metabolism_Homo sapiens_hsa000510.79732219
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79633034
50Alzheimers disease_Homo sapiens_hsa050100.78544517
51Apoptosis_Homo sapiens_hsa042100.77994677
52Small cell lung cancer_Homo sapiens_hsa052220.76620351
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76229801
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.76184632
55Shigellosis_Homo sapiens_hsa051310.74301806
56Fatty acid elongation_Homo sapiens_hsa000620.71293118
57Acute myeloid leukemia_Homo sapiens_hsa052210.71219720
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70555369
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69297449
60N-Glycan biosynthesis_Homo sapiens_hsa005100.69181450
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69166275
62Chronic myeloid leukemia_Homo sapiens_hsa052200.68526150
63Thyroid cancer_Homo sapiens_hsa052160.67712926
64Folate biosynthesis_Homo sapiens_hsa007900.67242975
65Leishmaniasis_Homo sapiens_hsa051400.67110854
66Hepatitis B_Homo sapiens_hsa051610.66393299
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66197728
68Basal cell carcinoma_Homo sapiens_hsa052170.65835412
69B cell receptor signaling pathway_Homo sapiens_hsa046620.65583819
70T cell receptor signaling pathway_Homo sapiens_hsa046600.65556357
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63447360
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61521758
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.60587697
74Viral myocarditis_Homo sapiens_hsa054160.56662005
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.56612442
76Influenza A_Homo sapiens_hsa051640.52894159
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51763498
78Propanoate metabolism_Homo sapiens_hsa006400.51065792
79Selenocompound metabolism_Homo sapiens_hsa004500.50130797
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50079395
81Metabolic pathways_Homo sapiens_hsa011000.49864956
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48800698
83Allograft rejection_Homo sapiens_hsa053300.47770671
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47619163
85Steroid biosynthesis_Homo sapiens_hsa001000.47522050
86Toxoplasmosis_Homo sapiens_hsa051450.47070023
87MicroRNAs in cancer_Homo sapiens_hsa052060.46794106
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.46725869
89Biosynthesis of amino acids_Homo sapiens_hsa012300.46407164
90Notch signaling pathway_Homo sapiens_hsa043300.44723217
91Colorectal cancer_Homo sapiens_hsa052100.44273867
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44052790
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.44000218
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43341526
95Bladder cancer_Homo sapiens_hsa052190.42922202
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40976787
97Asthma_Homo sapiens_hsa053100.40324829
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36962501
99Osteoclast differentiation_Homo sapiens_hsa043800.35700190
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35194550
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34997329
102HIF-1 signaling pathway_Homo sapiens_hsa040660.34363349
103Glutathione metabolism_Homo sapiens_hsa004800.33996696
104Arginine and proline metabolism_Homo sapiens_hsa003300.32866767
105Huntingtons disease_Homo sapiens_hsa050160.32532463
106Hippo signaling pathway_Homo sapiens_hsa043900.32162752
107Parkinsons disease_Homo sapiens_hsa050120.31759088
108Lysine degradation_Homo sapiens_hsa003100.31364558
109Prostate cancer_Homo sapiens_hsa052150.30496937
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30346506
111Alcoholism_Homo sapiens_hsa050340.30176551
112Non-small cell lung cancer_Homo sapiens_hsa052230.30039886
113Oocyte meiosis_Homo sapiens_hsa041140.29792959
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29763433
115Wnt signaling pathway_Homo sapiens_hsa043100.29030331
116Platelet activation_Homo sapiens_hsa046110.28828641
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28706433
118Pancreatic cancer_Homo sapiens_hsa052120.28672531
119Graft-versus-host disease_Homo sapiens_hsa053320.28465533
120Pathways in cancer_Homo sapiens_hsa052000.28263617
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27906169
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27714567
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26417196
124TNF signaling pathway_Homo sapiens_hsa046680.26088551
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25882867
126Hedgehog signaling pathway_Homo sapiens_hsa043400.25652149
127Arginine biosynthesis_Homo sapiens_hsa002200.25036035
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.24056388
129Galactose metabolism_Homo sapiens_hsa000520.23020065
130TGF-beta signaling pathway_Homo sapiens_hsa043500.22818776
131Endometrial cancer_Homo sapiens_hsa052130.17551094
132Melanoma_Homo sapiens_hsa052180.16872989
133Cardiac muscle contraction_Homo sapiens_hsa042600.15683446
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12454434
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12247470
136Vitamin digestion and absorption_Homo sapiens_hsa049770.12226468
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10266353

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