ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.58131347
2	DNA deamination (GO:0045006)	4.38450843
3	viral transcription (GO:0019083)	4.23830485
4	ATP synthesis coupled proton transport (GO:0015986)	4.15733904
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.15733904
6	protein complex biogenesis (GO:0070271)	4.13734993
7	translational termination (GO:0006415)	4.10147429
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.09998413
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.99267506
10	NADH dehydrogenase complex assembly (GO:0010257)	3.99267506
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.99267506
12	ribosomal small subunit biogenesis (GO:0042274)	3.96627303
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.92251932
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.81560632
15	ribosomal small subunit assembly (GO:0000028)	3.80708126
16	tryptophan catabolic process (GO:0006569)	3.70151250
17	indole-containing compound catabolic process (GO:0042436)	3.70151250
18	indolalkylamine catabolic process (GO:0046218)	3.70151250
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.64751688
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.64366283
21	kynurenine metabolic process (GO:0070189)	3.58326350
22	indolalkylamine metabolic process (GO:0006586)	3.54486194
23	response to pheromone (GO:0019236)	3.53147045
24	translational elongation (GO:0006414)	3.42292990
25	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.41147653
26	cotranslational protein targeting to membrane (GO:0006613)	3.37940993
27	protein targeting to ER (GO:0045047)	3.34176319
28	chaperone-mediated protein transport (GO:0072321)	3.33350963
29	maturation of SSU-rRNA (GO:0030490)	3.26687726
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.16924597
31	protein localization to endoplasmic reticulum (GO:0070972)	3.12897543
32	platelet dense granule organization (GO:0060155)	3.12408716
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11856292
34	tryptophan metabolic process (GO:0006568)	3.11472928
35	L-fucose catabolic process (GO:0042355)	3.08122490
36	fucose catabolic process (GO:0019317)	3.08122490
37	L-fucose metabolic process (GO:0042354)	3.08122490
38	electron transport chain (GO:0022900)	3.03985743
39	cytochrome complex assembly (GO:0017004)	3.02730632
40	protein-cofactor linkage (GO:0018065)	3.02003157
41	respiratory chain complex IV assembly (GO:0008535)	2.99808993
42	respiratory electron transport chain (GO:0022904)	2.97624878
43	cellular protein complex disassembly (GO:0043624)	2.96156594
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.95805308
45	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.95805308
46	viral life cycle (GO:0019058)	2.95116344
47	cellular ketone body metabolic process (GO:0046950)	2.94000206
48	protein polyglutamylation (GO:0018095)	2.92247150
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.89981465
50	gamma-aminobutyric acid transport (GO:0015812)	2.88198042
51	protein neddylation (GO:0045116)	2.87571490
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.85690065
53	sulfation (GO:0051923)	2.82910966
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.80938724
55	detection of light stimulus involved in visual perception (GO:0050908)	2.80938724
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77713929
57	negative regulation of telomere maintenance (GO:0032205)	2.76109527
58	cell proliferation in forebrain (GO:0021846)	2.74939713
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73927364
60	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73727160
61	piRNA metabolic process (GO:0034587)	2.72957892
62	nonmotile primary cilium assembly (GO:0035058)	2.71744408
63	axoneme assembly (GO:0035082)	2.71213901
64	indole-containing compound metabolic process (GO:0042430)	2.71161753
65	pseudouridine synthesis (GO:0001522)	2.70460352
66	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.67169781
67	negative regulation of T cell differentiation in thymus (GO:0033085)	2.66304383
68	positive regulation of prostaglandin secretion (GO:0032308)	2.65591791
69	positive regulation of fatty acid transport (GO:2000193)	2.63831031
70	epithelial cilium movement (GO:0003351)	2.63247513
71	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.62077225
72	ketone body metabolic process (GO:1902224)	2.61943526
73	negative regulation of mast cell activation (GO:0033004)	2.61862584
74	cellular response to ATP (GO:0071318)	2.61550817
75	ATP biosynthetic process (GO:0006754)	2.61327746
76	regulation of mesoderm development (GO:2000380)	2.59660597
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58984214
78	termination of RNA polymerase III transcription (GO:0006386)	2.58984214
79	base-excision repair, AP site formation (GO:0006285)	2.56240400
80	cellular biogenic amine catabolic process (GO:0042402)	2.54729625
81	amine catabolic process (GO:0009310)	2.54729625
82	hydrogen ion transmembrane transport (GO:1902600)	2.53537491
83	negative regulation of systemic arterial blood pressure (GO:0003085)	2.52991345
84	regulation of cilium movement (GO:0003352)	2.50628072
85	intracellular protein transmembrane import (GO:0044743)	2.50559462
86	somite development (GO:0061053)	2.49935826
87	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.49864211
88	positive regulation of defense response to virus by host (GO:0002230)	2.49022128
89	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.48719553
90	multicellular organism reproduction (GO:0032504)	2.48043491
91	translational initiation (GO:0006413)	2.47384409
92	mannosylation (GO:0097502)	2.47350855
93	parturition (GO:0007567)	2.46350571
94	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.45319058
95	ubiquinone biosynthetic process (GO:0006744)	2.45203535
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.43871930
97	proton transport (GO:0015992)	2.43542414
98	cellular component biogenesis (GO:0044085)	2.42337049
99	behavioral response to ethanol (GO:0048149)	2.42011434
100	translation (GO:0006412)	2.40720736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.41062944
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44247047
3	VDR_22108803_ChIP-Seq_LS180_Human	3.23827185
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.67223583
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49864411
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.25682113
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18956228
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00619444
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.00477742
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98108364
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95513255
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.89752992
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89728504
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89380396
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88233860
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.86375749
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85584570
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.85511042
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85329802
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84549705
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83802950
22	EWS_26573619_Chip-Seq_HEK293_Human	1.80795875
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80085912
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74237952
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70644058
26	FUS_26573619_Chip-Seq_HEK293_Human	1.70272512
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.69246339
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64152607
29	P300_19829295_ChIP-Seq_ESCs_Human	1.60856097
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57775758
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56071249
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.51938950
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.51393874
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48011016
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.46901710
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.43782537
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43063346
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43063346
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41584310
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41108055
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40691370
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37525875
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36367221
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.33626066
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33023239
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.32694452
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31959936
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31959936
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.31311541
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.28779847
51	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27359230
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26608849
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.26484783
54	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25837993
55	* CBP_20019798_ChIP-Seq_JUKART_Human	1.25837993
56	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25769071
57	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25459187
58	* NCOR_22424771_ChIP-Seq_293T_Human	1.25353124
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24630052
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.24497153
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24351378
62	AR_20517297_ChIP-Seq_VCAP_Human	1.22128131
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18173490
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17796184
65	AR_25329375_ChIP-Seq_VCAP_Human	1.14839347
66	* ERA_21632823_ChIP-Seq_H3396_Human	1.13881292
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13325386
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10447064
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09402852
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09103561
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08244001
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08244001
73	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.08237961
74	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06870842
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.06719551
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06646536
77	TCF4_23295773_ChIP-Seq_U87_Human	1.05981809
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05374598
79	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04728238
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.04176733
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.04101007
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04046191
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03876133
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03831924
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03660448
86	STAT3_23295773_ChIP-Seq_U87_Human	1.03598539
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02495492
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02406251
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02207979
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01566653
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01546345
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00966652
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99297809
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98984335
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98390361
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97518642
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97472602
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96677718
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96463461
100	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95967391

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.26322233
2	MP0009379_abnormal_foot_pigmentation	2.83757854
3	MP0002653_abnormal_ependyma_morphology	2.75984066
4	MP0003195_calcinosis	2.43916574
5	MP0003646_muscle_fatigue	2.40808715
6	MP0002837_dystrophic_cardiac_calcinosis	2.36811609
7	MP0001968_abnormal_touch/_nociception	2.30280268
8	MP0005551_abnormal_eye_electrophysiolog	2.26662829
9	MP0004142_abnormal_muscle_tone	2.07417913
10	MP0008872_abnormal_physiological_respon	2.04342968
11	MP0002736_abnormal_nociception_after	1.94683700
12	MP0004885_abnormal_endolymph	1.93659096
13	MP0005646_abnormal_pituitary_gland	1.89741013
14	MP0002102_abnormal_ear_morphology	1.89460047
15	MP0008877_abnormal_DNA_methylation	1.88107857
16	MP0003136_yellow_coat_color	1.85868345
17	MP0009745_abnormal_behavioral_response	1.85318597
18	MP0006072_abnormal_retinal_apoptosis	1.81546928
19	MP0001485_abnormal_pinna_reflex	1.78642658
20	MP0005377_hearing/vestibular/ear_phenot	1.71436236
21	MP0003878_abnormal_ear_physiology	1.71436236
22	MP0002938_white_spotting	1.71068134
23	MP0002876_abnormal_thyroid_physiology	1.70955096
24	MP0009046_muscle_twitch	1.67976181
25	MP0002638_abnormal_pupillary_reflex	1.67111797
26	MP0005645_abnormal_hypothalamus_physiol	1.64472926
27	MP0002163_abnormal_gland_morphology	1.63601128
28	MP0002160_abnormal_reproductive_system	1.63553404
29	MP0003283_abnormal_digestive_organ	1.61525784
30	MP0001905_abnormal_dopamine_level	1.61010534
31	MP0000631_abnormal_neuroendocrine_gland	1.56940295
32	MP0002272_abnormal_nervous_system	1.56537019
33	MP0001501_abnormal_sleep_pattern	1.53691966
34	MP0008875_abnormal_xenobiotic_pharmacok	1.49959304
35	MP0000372_irregular_coat_pigmentation	1.49372517
36	MP0003011_delayed_dark_adaptation	1.48390352
37	MP0004145_abnormal_muscle_electrophysio	1.46801956
38	MP0005253_abnormal_eye_physiology	1.46000874
39	MP0004133_heterotaxia	1.43372451
40	MP0002735_abnormal_chemical_nociception	1.41045518
41	MP0001986_abnormal_taste_sensitivity	1.40833362
42	MP0005389_reproductive_system_phenotype	1.40732552
43	MP0002277_abnormal_respiratory_mucosa	1.39152781
44	MP0005084_abnormal_gallbladder_morpholo	1.37908022
45	MP0006276_abnormal_autonomic_nervous	1.37509501
46	MP0005671_abnormal_response_to	1.36617182
47	MP0003880_abnormal_central_pattern	1.33755321
48	MP0002733_abnormal_thermal_nociception	1.29661086
49	MP0005379_endocrine/exocrine_gland_phen	1.28137502
50	MP0002234_abnormal_pharynx_morphology	1.26018620
51	MP0005410_abnormal_fertilization	1.25217415
52	MP0003787_abnormal_imprinting	1.24697200
53	MP0001970_abnormal_pain_threshold	1.22829271
54	MP0002572_abnormal_emotion/affect_behav	1.22771960
55	MP0000049_abnormal_middle_ear	1.21386521
56	MP0004147_increased_porphyrin_level	1.19914161
57	MP0002557_abnormal_social/conspecific_i	1.16718694
58	MP0005174_abnormal_tail_pigmentation	1.15743202
59	MP0001486_abnormal_startle_reflex	1.15032359
60	MP0005195_abnormal_posterior_eye	1.14584871
61	MP0002064_seizures	1.13984634
62	MP0000026_abnormal_inner_ear	1.13482876
63	MP0008789_abnormal_olfactory_epithelium	1.12850300
64	MP0004043_abnormal_pH_regulation	1.10140368
65	MP0002095_abnormal_skin_pigmentation	1.08462812
66	MP0004742_abnormal_vestibular_system	1.08242815
67	MP0001919_abnormal_reproductive_system	1.07843630
68	MP0001440_abnormal_grooming_behavior	1.06811507
69	MP0002138_abnormal_hepatobiliary_system	1.05092644
70	MP0000569_abnormal_digit_pigmentation	0.98349313
71	MP0002067_abnormal_sensory_capabilities	0.97825802
72	MP0001529_abnormal_vocalization	0.97375912
73	MP0001963_abnormal_hearing_physiology	0.97169410
74	MP0002752_abnormal_somatic_nervous	0.94932553
75	MP0002734_abnormal_mechanical_nocicepti	0.91753716
76	MP0005423_abnormal_somatic_nervous	0.91687391
77	MP0003879_abnormal_hair_cell	0.88610360
78	MP0010386_abnormal_urinary_bladder	0.87860936
79	MP0002928_abnormal_bile_duct	0.87409267
80	MP0005332_abnormal_amino_acid	0.86055760
81	MP0003635_abnormal_synaptic_transmissio	0.84272403
82	MP0003698_abnormal_male_reproductive	0.83442452
83	MP0002210_abnormal_sex_determination	0.83386033
84	MP0000230_abnormal_systemic_arterial	0.83066362
85	MP0003137_abnormal_impulse_conducting	0.82393384
86	MP0008995_early_reproductive_senescence	0.82335905
87	MP0001293_anophthalmia	0.82278865
88	MP0002063_abnormal_learning/memory/cond	0.80588698
89	MP0003718_maternal_effect	0.80009223
90	MP0002184_abnormal_innervation	0.78375828
91	MP0005386_behavior/neurological_phenoty	0.76966153
92	MP0004924_abnormal_behavior	0.76966153
93	MP0003119_abnormal_digestive_system	0.76887135
94	MP0001502_abnormal_circadian_rhythm	0.75870879
95	MP0002229_neurodegeneration	0.75677662
96	MP0001984_abnormal_olfaction	0.74892991
97	MP0009764_decreased_sensitivity_to	0.74440744
98	MP0001765_abnormal_ion_homeostasis	0.73645250
99	MP0001929_abnormal_gametogenesis	0.72732635
100	MP0000778_abnormal_nervous_system	0.71801667

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.04121196
2	Congenital stationary night blindness (HP:0007642)	3.78351536
3	Abnormality of midbrain morphology (HP:0002418)	3.75912233
4	Molar tooth sign on MRI (HP:0002419)	3.75912233
5	Pancreatic fibrosis (HP:0100732)	3.73413322
6	True hermaphroditism (HP:0010459)	3.52370420
7	Nephronophthisis (HP:0000090)	3.24708970
8	Acute necrotizing encephalopathy (HP:0006965)	3.16860224
9	Type II lissencephaly (HP:0007260)	3.09124127
10	Abolished electroretinogram (ERG) (HP:0000550)	3.00607396
11	Pendular nystagmus (HP:0012043)	2.89924850
12	Mitochondrial inheritance (HP:0001427)	2.89451072
13	Sclerocornea (HP:0000647)	2.83175725
14	Abnormality of the renal medulla (HP:0100957)	2.76421748
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.72871461
16	Abnormality of the renal cortex (HP:0011035)	2.70321607
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.68453883
18	Congenital, generalized hypertrichosis (HP:0004540)	2.68183326
19	Chronic hepatic failure (HP:0100626)	2.67826037
20	Abnormal drinking behavior (HP:0030082)	2.67531463
21	Polydipsia (HP:0001959)	2.67531463
22	Progressive macrocephaly (HP:0004481)	2.67476118
23	Attenuation of retinal blood vessels (HP:0007843)	2.67401535
24	Increased CSF lactate (HP:0002490)	2.66629917
25	Acute encephalopathy (HP:0006846)	2.66081472
26	Abnormal number of erythroid precursors (HP:0012131)	2.65812703
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.65438445
28	Abnormality of alanine metabolism (HP:0010916)	2.65438445
29	Hyperalaninemia (HP:0003348)	2.65438445
30	Medial flaring of the eyebrow (HP:0010747)	2.65252074
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.65040272
32	Abnormality of cells of the erythroid lineage (HP:0012130)	2.63698755
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.61246923
34	3-Methylglutaconic aciduria (HP:0003535)	2.60496856
35	Genetic anticipation (HP:0003743)	2.49947640
36	Cystic liver disease (HP:0006706)	2.46715847
37	Reticulocytopenia (HP:0001896)	2.45299688
38	Decreased central vision (HP:0007663)	2.40389612
39	Hypoplasia of the pons (HP:0012110)	2.35651234
40	Methylmalonic acidemia (HP:0002912)	2.35537408
41	Progressive cerebellar ataxia (HP:0002073)	2.35455243
42	Abnormality of the pons (HP:0007361)	2.29613206
43	Absent thumb (HP:0009777)	2.28280340
44	Cerebellar dysplasia (HP:0007033)	2.27283922
45	Optic disc pallor (HP:0000543)	2.27098869
46	Increased corneal curvature (HP:0100692)	2.20920710
47	Keratoconus (HP:0000563)	2.20920710
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20698280
49	Absent/shortened dynein arms (HP:0200106)	2.20698280
50	Polyuria (HP:0000103)	2.20603135
51	Methylmalonic aciduria (HP:0012120)	2.20199045
52	Anencephaly (HP:0002323)	2.18877166
53	Retinal dysplasia (HP:0007973)	2.18138311
54	Macrocytic anemia (HP:0001972)	2.17610523
55	Concave nail (HP:0001598)	2.17200168
56	Lipid accumulation in hepatocytes (HP:0006561)	2.17048483
57	Hepatocellular necrosis (HP:0001404)	2.14769697
58	Tubular atrophy (HP:0000092)	2.13103810
59	Increased hepatocellular lipid droplets (HP:0006565)	2.09480881
60	Decreased circulating renin level (HP:0003351)	2.06718830
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01838482
62	Male pseudohermaphroditism (HP:0000037)	2.00442427
63	Renal Fanconi syndrome (HP:0001994)	1.99668935
64	Congenital hepatic fibrosis (HP:0002612)	1.99092644
65	Asplenia (HP:0001746)	1.97418816
66	Pallor (HP:0000980)	1.96452206
67	Hepatic necrosis (HP:0002605)	1.96157145
68	Hyperventilation (HP:0002883)	1.95653308
69	Abnormality of the renal collecting system (HP:0004742)	1.93931357
70	Gait imbalance (HP:0002141)	1.92337134
71	Abnormal respiratory epithelium morphology (HP:0012253)	1.91824671
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91824671
73	Large for gestational age (HP:0001520)	1.91600402
74	Abnormal ciliary motility (HP:0012262)	1.91297940
75	Gaze-evoked nystagmus (HP:0000640)	1.90138223
76	Septo-optic dysplasia (HP:0100842)	1.88409963
77	Congenital primary aphakia (HP:0007707)	1.88152784
78	Furrowed tongue (HP:0000221)	1.87919055
79	Hyperglycinemia (HP:0002154)	1.87807976
80	Renal cortical cysts (HP:0000803)	1.87661422
81	Abnormality of DNA repair (HP:0003254)	1.85361324
82	Constricted visual fields (HP:0001133)	1.85014894
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83639036
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.83511576
85	Increased serum lactate (HP:0002151)	1.83263778
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83068829
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.81289999
88	Chorioretinal atrophy (HP:0000533)	1.81224088
89	Optic nerve hypoplasia (HP:0000609)	1.81096367
90	IgG deficiency (HP:0004315)	1.78683301
91	Congenital sensorineural hearing impairment (HP:0008527)	1.77385106
92	Nephrogenic diabetes insipidus (HP:0009806)	1.76857996
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75668826
94	Abnormal urine output (HP:0012590)	1.75323033
95	Postaxial foot polydactyly (HP:0001830)	1.75273723
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73960698
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72234738
98	Colon cancer (HP:0003003)	1.71961191
99	Rib fusion (HP:0000902)	1.70703994
100	Cerebral edema (HP:0002181)	1.70209179

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.75901818
2	ADRBK2	3.82235077
3	TLK1	3.76480984
4	GRK1	2.90608091
5	INSRR	2.86581520
6	BMPR1B	2.66078748
7	ZAK	2.65275741
8	MAP4K2	2.49918226
9	WNK4	2.48658088
10	NUAK1	2.28760767
11	TAOK3	2.14786104
12	TXK	2.10473574
13	STK16	2.06706389
14	WNK3	1.90547668
15	VRK2	1.75754759
16	ACVR1B	1.74927983
17	PINK1	1.68656076
18	VRK1	1.51363939
19	BCKDK	1.43602859
20	CASK	1.36553233
21	ADRBK1	1.35853122
22	DYRK2	1.30884594
23	STK39	1.27324969
24	OXSR1	1.27107796
25	MAPK13	1.27006815
26	PRKCG	1.16256944
27	TIE1	1.14283259
28	IKBKB	1.13691380
29	MAP3K4	1.12324583
30	MAPK15	1.10368221
31	KIT	1.04259550
32	TAF1	1.02577386
33	CAMKK2	1.00281747
34	DAPK2	0.98973785
35	PHKG1	0.98860398
36	PHKG2	0.98860398
37	PASK	0.93911197
38	PIK3CA	0.93241650
39	PRKCE	0.91979814
40	TGFBR1	0.86342383
41	TNIK	0.85107411
42	MUSK	0.84493733
43	CDK19	0.80890639
44	NEK2	0.80425833
45	NTRK2	0.79756886
46	TEC	0.75603373
47	NTRK3	0.74576229
48	PNCK	0.73958823
49	PTK2B	0.73729172
50	MAP2K6	0.69870864
51	NME1	0.69396231
52	MKNK2	0.68276788
53	PLK4	0.67821317
54	PKN1	0.67528579
55	RPS6KA5	0.66322541
56	PRKCQ	0.66270882
57	GRK7	0.65829893
58	CSNK1G2	0.65305669
59	ITK	0.64818556
60	PAK3	0.64607841
61	CSNK1A1	0.62516177
62	GRK5	0.61999110
63	PLK2	0.61738961
64	CSNK1G3	0.61345797
65	PRKCI	0.61261929
66	CAMK1	0.61012188
67	STK11	0.60089056
68	PRKACA	0.58874150
69	RPS6KA6	0.54270122
70	CSNK1G1	0.53356713
71	SYK	0.52197606
72	MAPKAPK3	0.51744821
73	PRKCH	0.51584749
74	CHUK	0.51344662
75	MAP2K7	0.50791245
76	CAMK2A	0.50095154
77	MAPKAPK5	0.49898614
78	CDC7	0.49634877
79	PLK3	0.45387158
80	MARK3	0.45255970
81	PRKCA	0.45204636
82	CHEK2	0.44945166
83	ABL2	0.43508031
84	MARK1	0.43412476
85	PLK1	0.43145808
86	CSNK1A1L	0.42672549
87	BRSK2	0.41811864
88	GRK6	0.40198392
89	OBSCN	0.39825138
90	LYN	0.36373571
91	LCK	0.35449588
92	IKBKE	0.34858018
93	CSNK2A1	0.34807179
94	FLT3	0.33619549
95	MAP4K1	0.33169575
96	PIM1	0.32760349
97	PRKCD	0.32110332
98	CSNK1D	0.29377177
99	TNK2	0.29052278
100	MATK	0.28057154

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.02240555
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.48896552
3	Parkinsons disease_Homo sapiens_hsa05012	2.64195159
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31745549
5	Phototransduction_Homo sapiens_hsa04744	2.27933441
6	RNA polymerase_Homo sapiens_hsa03020	2.22375538
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20599407
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05730134
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.89391082
10	Nicotine addiction_Homo sapiens_hsa05033	1.87771515
11	Protein export_Homo sapiens_hsa03060	1.86447932
12	Sulfur relay system_Homo sapiens_hsa04122	1.85634864
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84887800
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84304333
15	Homologous recombination_Homo sapiens_hsa03440	1.84303334
16	Huntingtons disease_Homo sapiens_hsa05016	1.83665420
17	Alzheimers disease_Homo sapiens_hsa05010	1.77079282
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.72817719
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.72713162
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71357316
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67500751
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.63660606
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.60151746
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56593891
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.56551357
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55553518
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49815321
28	Butanoate metabolism_Homo sapiens_hsa00650	1.49759876
29	Basal transcription factors_Homo sapiens_hsa03022	1.40473160
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39540066
31	One carbon pool by folate_Homo sapiens_hsa00670	1.38847762
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.33197061
33	Asthma_Homo sapiens_hsa05310	1.29340940
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.26761043
35	RNA degradation_Homo sapiens_hsa03018	1.26553990
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24224880
37	Caffeine metabolism_Homo sapiens_hsa00232	1.20275760
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16699944
39	Morphine addiction_Homo sapiens_hsa05032	1.16524613
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.16320812
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12762506
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11231679
43	Proteasome_Homo sapiens_hsa03050	1.09059891
44	Graft-versus-host disease_Homo sapiens_hsa05332	1.08426270
45	Taste transduction_Homo sapiens_hsa04742	1.06397855
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04332887
47	Olfactory transduction_Homo sapiens_hsa04740	1.02002206
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01825995
49	Retinol metabolism_Homo sapiens_hsa00830	1.00763773
50	Peroxisome_Homo sapiens_hsa04146	0.95420088
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.93410740
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93061043
53	Allograft rejection_Homo sapiens_hsa05330	0.91086167
54	Sulfur metabolism_Homo sapiens_hsa00920	0.88619414
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87182323
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86695598
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85735803
58	Purine metabolism_Homo sapiens_hsa00230	0.83628498
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.82339916
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82187218
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79768481
62	Regulation of autophagy_Homo sapiens_hsa04140	0.78845714
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75478418
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71255605
65	Serotonergic synapse_Homo sapiens_hsa04726	0.70634480
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.70197953
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.69396582
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68335186
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68088425
70	GABAergic synapse_Homo sapiens_hsa04727	0.67963487
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.67409462
72	Insulin secretion_Homo sapiens_hsa04911	0.65413927
73	Metabolic pathways_Homo sapiens_hsa01100	0.65226516
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61687279
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61256681
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59333825
77	Propanoate metabolism_Homo sapiens_hsa00640	0.59034492
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56989480
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.55673704
80	Circadian entrainment_Homo sapiens_hsa04713	0.55334789
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55314000
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54973597
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52260600
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52206689
85	ABC transporters_Homo sapiens_hsa02010	0.51077971
86	Mineral absorption_Homo sapiens_hsa04978	0.51059578
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45685863
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.42117398
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.41596853
90	Salivary secretion_Homo sapiens_hsa04970	0.40300585
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39463432
92	Base excision repair_Homo sapiens_hsa03410	0.39345313
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38726134
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38396213
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37342210
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36496304
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34858576
98	Histidine metabolism_Homo sapiens_hsa00340	0.33183057
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30857639
100	Fatty acid degradation_Homo sapiens_hsa00071	0.28719148

RPLP0P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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