RPLP0P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.27206089
2DNA deamination (GO:0045006)5.99863067
3ribosomal small subunit biogenesis (GO:0042274)5.20506738
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10472314
5viral transcription (GO:0019083)4.70110586
6cytidine metabolic process (GO:0046087)4.67893077
7cytidine catabolic process (GO:0006216)4.67893077
8cytidine deamination (GO:0009972)4.67893077
9proteasome assembly (GO:0043248)4.54783710
10translational termination (GO:0006415)4.48169637
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46069646
12ATP synthesis coupled proton transport (GO:0015986)4.39134944
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39134944
14ncRNA 3-end processing (GO:0043628)4.30747495
15* translational elongation (GO:0006414)4.06548277
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.03922328
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.01487445
18cotranslational protein targeting to membrane (GO:0006613)3.95722488
19pyrimidine ribonucleoside catabolic process (GO:0046133)3.93534356
20protein targeting to ER (GO:0045047)3.93480931
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.87005191
22ribosomal large subunit biogenesis (GO:0042273)3.86385141
23maturation of SSU-rRNA (GO:0030490)3.79864507
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79114465
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.74259454
26protein localization to endoplasmic reticulum (GO:0070972)3.74185323
27platelet dense granule organization (GO:0060155)3.69368453
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67538990
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67538990
30water-soluble vitamin biosynthetic process (GO:0042364)3.57640430
31protein neddylation (GO:0045116)3.52938669
32viral life cycle (GO:0019058)3.43233784
33protein complex biogenesis (GO:0070271)3.42673328
34DNA strand renaturation (GO:0000733)3.41246201
35rRNA modification (GO:0000154)3.37912653
36respiratory electron transport chain (GO:0022904)3.35842803
37electron transport chain (GO:0022900)3.34652218
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.34172945
39NADH dehydrogenase complex assembly (GO:0010257)3.34172945
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34172945
41positive regulation of B cell differentiation (GO:0045579)3.32612432
42chaperone-mediated protein transport (GO:0072321)3.30562230
43cellular protein complex disassembly (GO:0043624)3.29234329
44translation (GO:0006412)3.21901736
45translational initiation (GO:0006413)3.21660338
46pseudouridine synthesis (GO:0001522)3.21434193
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13397391
48antigen processing and presentation via MHC class Ib (GO:0002475)3.08104108
49mitochondrial respiratory chain complex assembly (GO:0033108)3.06181016
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99209595
51regulation of cellular amino acid metabolic process (GO:0006521)2.97855784
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96829605
53purine nucleotide salvage (GO:0032261)2.96781838
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.94687783
55GTP biosynthetic process (GO:0006183)2.93457424
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90521912
57* cellular component biogenesis (GO:0044085)2.90484067
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87398332
59rRNA processing (GO:0006364)2.85732896
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85593158
61* ribonucleoprotein complex biogenesis (GO:0022613)2.84082049
62regulation of regulatory T cell differentiation (GO:0045589)2.82603658
63rRNA metabolic process (GO:0016072)2.78965239
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77703896
65respiratory chain complex IV assembly (GO:0008535)2.77419884
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76011980
67positive regulation of prostaglandin secretion (GO:0032308)2.73642212
68adaptation of signaling pathway (GO:0023058)2.73512446
69purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72747417
70regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.72719562
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71998017
72rRNA methylation (GO:0031167)2.71114006
73cytochrome complex assembly (GO:0017004)2.66938104
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65727168
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65727168
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65727168
77ATP biosynthetic process (GO:0006754)2.65221363
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63328292
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63328292
80purine-containing compound salvage (GO:0043101)2.62460607
81mannosylation (GO:0097502)2.62388880
82protein complex disassembly (GO:0043241)2.61898941
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.61205082
84termination of RNA polymerase III transcription (GO:0006386)2.61205082
85actin nucleation (GO:0045010)2.59859982
86T cell migration (GO:0072678)2.59590979
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59199669
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58107002
89RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.57645581
90piRNA metabolic process (GO:0034587)2.56638589
91male meiosis I (GO:0007141)2.56059204
92positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.51636174
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.50904849
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.50904849
95protein-cofactor linkage (GO:0018065)2.50794123
96iron-sulfur cluster assembly (GO:0016226)2.50672638
97metallo-sulfur cluster assembly (GO:0031163)2.50672638
98CTP metabolic process (GO:0046036)2.50156799
99CTP biosynthetic process (GO:0006241)2.50156799
100deoxyribonucleotide catabolic process (GO:0009264)2.49911691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.56836053
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.77301127
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.88858457
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61505344
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.56282520
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.01841164
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89954447
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85228580
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74507450
10VDR_22108803_ChIP-Seq_LS180_Human2.73955410
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.62076466
12EZH2_22144423_ChIP-Seq_EOC_Human2.59612297
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55047573
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.51621635
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.46208755
16VDR_23849224_ChIP-Seq_CD4+_Human2.38934876
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30173002
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19966659
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12665896
20FOXP3_21729870_ChIP-Seq_TREG_Human2.05682425
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.04403516
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.96304957
23ZNF274_21170338_ChIP-Seq_K562_Hela1.90600143
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75788035
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75212287
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73857217
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.70803823
28MYC_18940864_ChIP-ChIP_HL60_Human1.63324970
29ELK1_19687146_ChIP-ChIP_HELA_Human1.58953201
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51439651
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.51031342
32E2F7_22180533_ChIP-Seq_HELA_Human1.50749180
33TP53_22573176_ChIP-Seq_HFKS_Human1.50531029
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.49811489
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45945418
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45906560
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43985404
38IGF1R_20145208_ChIP-Seq_DFB_Human1.39837116
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39209335
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35097192
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33703810
42NCOR_22424771_ChIP-Seq_293T_Human1.33682061
43EWS_26573619_Chip-Seq_HEK293_Human1.29918416
44NANOG_20526341_ChIP-Seq_ESCs_Human1.28736214
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27429534
46MYB_26560356_Chip-Seq_TH2_Human1.26974022
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25966677
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23204215
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20280725
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19823431
51AR_20517297_ChIP-Seq_VCAP_Human1.19397043
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.19030311
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19030311
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15630463
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15234584
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.14655875
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14279522
58TAF2_19829295_ChIP-Seq_ESCs_Human1.13871648
59TTF2_22483619_ChIP-Seq_HELA_Human1.12826842
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10893610
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10736923
62GABP_19822575_ChIP-Seq_HepG2_Human1.10127951
63BCL6_27268052_Chip-Seq_Bcells_Human1.09674129
64GATA3_26560356_Chip-Seq_TH2_Human1.09479933
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08889642
66ERA_21632823_ChIP-Seq_H3396_Human1.07159532
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.06085916
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06017501
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05822461
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04277173
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04037897
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03255197
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02487074
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01648478
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01055213
76RUNX_20019798_ChIP-Seq_JUKART_Human1.00543562
77XRN2_22483619_ChIP-Seq_HELA_Human1.00070724
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99710471
79P300_27268052_Chip-Seq_Bcells_Human0.99503358
80P53_21459846_ChIP-Seq_SAOS-2_Human0.99214208
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.98883715
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98545221
83ERG_20517297_ChIP-Seq_VCAP_Human0.96432636
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95970123
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95917205
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95273929
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94166383
88MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93747629
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.93709353
90CTCF_20526341_ChIP-Seq_ESCs_Human0.93363418
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92900198
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92479239
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91844000
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91526740
95MYC_19829295_ChIP-Seq_ESCs_Human0.90359499
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89956722
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.89888888
98NANOG_19829295_ChIP-Seq_ESCs_Human0.89883972
99SOX2_19829295_ChIP-Seq_ESCs_Human0.89883972
100RBPJ_21746931_ChIP-Seq_IB4_Human0.89213494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.01312466
2MP0002102_abnormal_ear_morphology3.32322713
3MP0003646_muscle_fatigue3.10284591
4MP0001835_abnormal_antigen_presentation3.09064083
5MP0001873_stomach_inflammation2.74535792
6MP0006292_abnormal_olfactory_placode2.74522065
7MP0009379_abnormal_foot_pigmentation2.72417060
8MP0005645_abnormal_hypothalamus_physiol2.66806778
9MP0003878_abnormal_ear_physiology2.32032387
10MP0005377_hearing/vestibular/ear_phenot2.32032387
11MP0008872_abnormal_physiological_respon2.20440330
12MP0002166_altered_tumor_susceptibility2.18322597
13MP0005646_abnormal_pituitary_gland2.01193789
14MP0004147_increased_porphyrin_level1.96119554
15MP0009333_abnormal_splenocyte_physiolog1.93415955
16MP0000685_abnormal_immune_system1.90307133
17MP0000372_irregular_coat_pigmentation1.89364670
18MP0002006_tumorigenesis1.84051957
19MP0008875_abnormal_xenobiotic_pharmacok1.77292442
20MP0009785_altered_susceptibility_to1.76523475
21MP0008877_abnormal_DNA_methylation1.76305898
22MP0006072_abnormal_retinal_apoptosis1.70781111
23MP0002148_abnormal_hypersensitivity_rea1.66834379
24MP0002163_abnormal_gland_morphology1.64895564
25MP0006082_CNS_inflammation1.61753183
26MP0008995_early_reproductive_senescence1.56438001
27MP0002837_dystrophic_cardiac_calcinosis1.55533303
28MP0005389_reproductive_system_phenotype1.55291967
29MP0002876_abnormal_thyroid_physiology1.54185641
30MP0003763_abnormal_thymus_physiology1.53113864
31MP0008058_abnormal_DNA_repair1.51969630
32MP0001800_abnormal_humoral_immune1.50642079
33MP0005551_abnormal_eye_electrophysiolog1.50606873
34MP0002736_abnormal_nociception_after1.45307012
35MP0002160_abnormal_reproductive_system1.44816081
36MP0002234_abnormal_pharynx_morphology1.44460206
37MP0005084_abnormal_gallbladder_morpholo1.42058821
38MP0001905_abnormal_dopamine_level1.40778724
39MP0001968_abnormal_touch/_nociception1.39906325
40MP0004145_abnormal_muscle_electrophysio1.38613959
41MP0005075_abnormal_melanosome_morpholog1.35677149
42MP0005360_urolithiasis1.32241168
43MP0003786_premature_aging1.31523402
44MP0001764_abnormal_homeostasis1.31468940
45MP0001919_abnormal_reproductive_system1.31178121
46MP0003718_maternal_effect1.29069957
47MP0002933_joint_inflammation1.28952427
48MP0001790_abnormal_immune_system1.28884093
49MP0005387_immune_system_phenotype1.28884093
50MP0005000_abnormal_immune_tolerance1.27748828
51MP0002420_abnormal_adaptive_immunity1.27671416
52MP0003879_abnormal_hair_cell1.27069726
53MP0008789_abnormal_olfactory_epithelium1.24890887
54MP0001819_abnormal_immune_cell1.22918570
55MP0002723_abnormal_immune_serum1.20773058
56MP0004142_abnormal_muscle_tone1.17768584
57MP0003693_abnormal_embryo_hatching1.16527336
58MP0003866_abnormal_defecation1.13945831
59MP0002095_abnormal_skin_pigmentation1.11714625
60MP0005025_abnormal_response_to1.10907651
61MP0004885_abnormal_endolymph1.10905429
62MP0001485_abnormal_pinna_reflex1.10811530
63MP0003806_abnormal_nucleotide_metabolis1.05944272
64MP0002398_abnormal_bone_marrow1.05028786
65MP0002277_abnormal_respiratory_mucosa1.04375364
66MP0002138_abnormal_hepatobiliary_system1.03223319
67MP0002452_abnormal_antigen_presenting1.02366487
68MP0009764_decreased_sensitivity_to1.01659460
69MP0005379_endocrine/exocrine_gland_phen1.00296297
70MP0000716_abnormal_immune_system0.99624729
71MP0000689_abnormal_spleen_morphology0.99499825
72MP0005636_abnormal_mineral_homeostasis0.98771759
73MP0003195_calcinosis0.97542381
74MP0000703_abnormal_thymus_morphology0.95720597
75MP0001119_abnormal_female_reproductive0.95495775
76MP0000631_abnormal_neuroendocrine_gland0.93753887
77MP0005410_abnormal_fertilization0.93341207
78MP0001986_abnormal_taste_sensitivity0.92592010
79MP0010155_abnormal_intestine_physiology0.88294453
80MP0002722_abnormal_immune_system0.87527059
81MP0001845_abnormal_inflammatory_respons0.86520086
82MP0002405_respiratory_system_inflammati0.85429395
83MP0002210_abnormal_sex_determination0.85404743
84MP0001663_abnormal_digestive_system0.83716585
85MP0002429_abnormal_blood_cell0.81848346
86MP0006036_abnormal_mitochondrial_physio0.81662881
87MP0000566_synostosis0.81557750
88MP0005253_abnormal_eye_physiology0.81414850
89MP0001664_abnormal_digestion0.80648463
90MP0006276_abnormal_autonomic_nervous0.80335637
91MP0004043_abnormal_pH_regulation0.79277934
92MP0005332_abnormal_amino_acid0.77509800
93MP0005085_abnormal_gallbladder_physiolo0.76872970
94MP0003186_abnormal_redox_activity0.76061459
95MP0000049_abnormal_middle_ear0.75949832
96MP0004742_abnormal_vestibular_system0.73910559
97MP0005464_abnormal_platelet_physiology0.71308985
98MP0005174_abnormal_tail_pigmentation0.71000218
99MP0001929_abnormal_gametogenesis0.69388872
100MP0009643_abnormal_urine_homeostasis0.68993839

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.33073575
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.82250545
3Acute necrotizing encephalopathy (HP:0006965)3.73896169
4Mitochondrial inheritance (HP:0001427)3.65498952
5Aplastic anemia (HP:0001915)3.58865312
6Decreased electroretinogram (ERG) amplitude (HP:0000654)3.57188047
7Congenital stationary night blindness (HP:0007642)3.42126027
8Constricted visual fields (HP:0001133)3.41171645
9Reticulocytopenia (HP:0001896)3.31586539
10Acute encephalopathy (HP:0006846)3.30204328
11Abnormal mitochondria in muscle tissue (HP:0008316)3.29489886
12Abnormality of macular pigmentation (HP:0008002)3.29063123
13Increased CSF lactate (HP:0002490)3.17453380
14IgG deficiency (HP:0004315)3.12947482
15Abnormal rod and cone electroretinograms (HP:0008323)3.08561653
16Progressive macrocephaly (HP:0004481)3.05996128
17Hypoproteinemia (HP:0003075)3.05299257
18Hepatocellular necrosis (HP:0001404)2.99874073
19Attenuation of retinal blood vessels (HP:0007843)2.99331233
20Increased IgM level (HP:0003496)2.96343100
21Chronic otitis media (HP:0000389)2.93223770
22Muscle fiber atrophy (HP:0100295)2.89989194
23Hepatic necrosis (HP:0002605)2.88603618
24Increased hepatocellular lipid droplets (HP:0006565)2.87936154
25Renal Fanconi syndrome (HP:0001994)2.80774899
26Chronic sinusitis (HP:0011109)2.79531238
27Severe combined immunodeficiency (HP:0004430)2.71748027
28Optic disc pallor (HP:0000543)2.71614547
29Abnormality of cells of the erythroid lineage (HP:0012130)2.71153485
30Abolished electroretinogram (ERG) (HP:0000550)2.70544197
31Abnormal number of erythroid precursors (HP:0012131)2.69462297
32Abnormality of B cell number (HP:0010975)2.65363085
33Cerebral edema (HP:0002181)2.61467795
343-Methylglutaconic aciduria (HP:0003535)2.59750223
35Pancreatic cysts (HP:0001737)2.59011171
36Lipid accumulation in hepatocytes (HP:0006561)2.52263741
37Increased intramyocellular lipid droplets (HP:0012240)2.46103965
38B lymphocytopenia (HP:0010976)2.42202672
39Lactic acidosis (HP:0003128)2.34683761
40Severe visual impairment (HP:0001141)2.31188989
41Absent thumb (HP:0009777)2.31085530
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.30807042
43Generalized aminoaciduria (HP:0002909)2.30252895
44True hermaphroditism (HP:0010459)2.29093186
45Methylmalonic acidemia (HP:0002912)2.27550865
46Increased serum lactate (HP:0002151)2.27288429
47Hypoplasia of the uterus (HP:0000013)2.26890293
48Pancreatic fibrosis (HP:0100732)2.26482936
49Large eyes (HP:0001090)2.26259777
50Asplenia (HP:0001746)2.25711651
51Decreased central vision (HP:0007663)2.25552908
52Macrocytic anemia (HP:0001972)2.24328147
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24147134
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24147134
55Abnormality of midbrain morphology (HP:0002418)2.23765060
56Molar tooth sign on MRI (HP:0002419)2.23765060
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23607932
58Respiratory difficulties (HP:0002880)2.22434759
59Pancytopenia (HP:0001876)2.18132124
60Thyroiditis (HP:0100646)2.15987497
61Lethargy (HP:0001254)2.15898836
62Autoimmune thrombocytopenia (HP:0001973)2.15035195
63Methylmalonic aciduria (HP:0012120)2.12635406
64Exertional dyspnea (HP:0002875)2.11279738
65Autoimmune hemolytic anemia (HP:0001890)2.09571518
66Abnormality of alanine metabolism (HP:0010916)2.08416240
67Hyperalaninemia (HP:0003348)2.08416240
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08416240
69Hyperglycinemia (HP:0002154)2.07962129
70Pallor (HP:0000980)2.06602434
71Aplasia/hypoplasia of the uterus (HP:0008684)2.06215586
72Renal cortical cysts (HP:0000803)2.05820844
73Abnormality of urine glucose concentration (HP:0011016)2.03360765
74Glycosuria (HP:0003076)2.03360765
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02462982
76Dicarboxylic aciduria (HP:0003215)2.02462982
77Pendular nystagmus (HP:0012043)2.01919678
78Combined immunodeficiency (HP:0005387)2.00465992
79Abnormality of the renal cortex (HP:0011035)1.95537250
80Increased muscle lipid content (HP:0009058)1.93489065
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92096365
82Panhypogammaglobulinemia (HP:0003139)1.91653754
83Abnormality of T cell number (HP:0011839)1.89635090
84Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88152501
85Abnormality of renal resorption (HP:0011038)1.87411161
86Type I transferrin isoform profile (HP:0003642)1.85518120
87Stomatitis (HP:0010280)1.84525100
88Abnormality of T cells (HP:0002843)1.83733193
89T lymphocytopenia (HP:0005403)1.83250366
90Reduced antithrombin III activity (HP:0001976)1.82194669
91Respiratory failure (HP:0002878)1.79778463
92Abnormality of the phalanges of the 5th finger (HP:0004213)1.77638492
93Recurrent bronchitis (HP:0002837)1.77595880
94Abnormality of the renal collecting system (HP:0004742)1.77261043
95Abnormality of the prostate (HP:0008775)1.74072911
96Type 2 muscle fiber atrophy (HP:0003554)1.73395646
97Reduced subcutaneous adipose tissue (HP:0003758)1.72000900
98Exercise intolerance (HP:0003546)1.71000165
99Ketosis (HP:0001946)1.70404653
100Nephronophthisis (HP:0000090)1.69737121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.43674633
2TXK3.20338524
3KDR3.15723997
4VRK23.03244081
5BCKDK2.89944222
6ZAK2.86437865
7GRK12.53984826
8KIT2.39311502
9WNK42.38891885
10NUAK12.20119696
11ADRBK22.19935966
12MAP4K22.15555141
13TLK12.00290327
14PINK11.84299815
15STK161.83645748
16MAP4K11.80137494
17TAOK31.79294990
18TIE11.79103341
19TEC1.73819613
20STK391.71955566
21FES1.70919685
22VRK11.70888849
23CDK191.64736276
24GRK71.53431853
25BUB11.45538045
26NME21.40532607
27FRK1.29408919
28PASK1.24078472
29SYK1.18012523
30PRKCQ1.15410351
31MST41.13134878
32INSRR1.10054946
33IKBKB1.08402857
34LIMK11.08395114
35TESK11.04381512
36WNK31.04377570
37NME11.03290702
38ITK1.02241140
39EIF2AK30.92896554
40JAK30.92001996
41GRK50.91949917
42IKBKE0.91630970
43MUSK0.87970005
44SCYL20.85060044
45STK240.84064989
46TNK20.83917695
47MAPKAPK30.82823916
48ADRBK10.81085680
49AURKA0.80324387
50CCNB10.78790148
51DYRK20.77595085
52RPS6KA50.75501985
53CSF1R0.75449855
54LCK0.73641849
55DAPK10.72467238
56MAP3K110.71331998
57GRK60.70635174
58RPS6KB20.66615004
59OBSCN0.65869308
60LYN0.65279437
61EIF2AK20.65150784
62ILK0.63287322
63CAMKK20.62918929
64NEK10.62039365
65OXSR10.61504644
66ACVR1B0.59508087
67PIM10.58881798
68TAF10.57552019
69BMPR1B0.57342956
70BTK0.57044796
71CHEK20.56465127
72TRIM280.55934662
73TGFBR20.55541892
74MAP3K120.55430651
75CSNK1G30.54437939
76PIM20.52000031
77MAPKAPK50.51149530
78PLK40.50803989
79PRKACA0.49109314
80MOS0.48691338
81MAPK130.47213284
82CSNK2A10.46924241
83CDC70.46913683
84PHKG10.44091919
85PHKG20.44091919
86PRKCA0.44026418
87MAP2K70.43936676
88PLK30.43661350
89PIK3CG0.43429162
90RPS6KA60.41512458
91PRKCD0.41478629
92PLK10.40899060
93IGF1R0.40885195
94DAPK30.40718314
95PRKCG0.38193988
96SRPK10.37898675
97PDK20.37397990
98DAPK20.37349962
99MATK0.37232871
100CSNK2A20.37200356

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.55182095
2Proteasome_Homo sapiens_hsa030503.89251182
3Primary immunodeficiency_Homo sapiens_hsa053403.52140947
4Oxidative phosphorylation_Homo sapiens_hsa001903.46227224
5Parkinsons disease_Homo sapiens_hsa050122.79350933
6RNA polymerase_Homo sapiens_hsa030202.24688992
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10360323
8Protein export_Homo sapiens_hsa030601.97408566
9Allograft rejection_Homo sapiens_hsa053301.90296164
10Phototransduction_Homo sapiens_hsa047441.86273350
11Huntingtons disease_Homo sapiens_hsa050161.84156853
12Homologous recombination_Homo sapiens_hsa034401.82550635
13Alzheimers disease_Homo sapiens_hsa050101.81472353
14Autoimmune thyroid disease_Homo sapiens_hsa053201.75447692
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.66638134
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59225249
17Graft-versus-host disease_Homo sapiens_hsa053321.58062129
18Linoleic acid metabolism_Homo sapiens_hsa005911.57854215
19Asthma_Homo sapiens_hsa053101.56216776
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55906053
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53934942
22One carbon pool by folate_Homo sapiens_hsa006701.49649753
23Type I diabetes mellitus_Homo sapiens_hsa049401.49327362
24Pyrimidine metabolism_Homo sapiens_hsa002401.44334011
25Mismatch repair_Homo sapiens_hsa034301.43629221
26Cardiac muscle contraction_Homo sapiens_hsa042601.43374244
27Antigen processing and presentation_Homo sapiens_hsa046121.39503781
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37912583
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35946508
30Sulfur metabolism_Homo sapiens_hsa009201.34246422
31DNA replication_Homo sapiens_hsa030301.33658800
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33454245
33Hematopoietic cell lineage_Homo sapiens_hsa046401.29603488
34Basal transcription factors_Homo sapiens_hsa030221.28307267
35Fanconi anemia pathway_Homo sapiens_hsa034601.24980019
36Nitrogen metabolism_Homo sapiens_hsa009101.19124201
37RNA degradation_Homo sapiens_hsa030181.14301126
38Caffeine metabolism_Homo sapiens_hsa002321.10460149
39Peroxisome_Homo sapiens_hsa041461.09386771
40Nucleotide excision repair_Homo sapiens_hsa034201.08866127
41Base excision repair_Homo sapiens_hsa034101.07770077
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05509489
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.03840206
44Propanoate metabolism_Homo sapiens_hsa006401.02563281
45Purine metabolism_Homo sapiens_hsa002301.01345957
46Arachidonic acid metabolism_Homo sapiens_hsa005900.94201786
47Retinol metabolism_Homo sapiens_hsa008300.90558781
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89906157
49Butanoate metabolism_Homo sapiens_hsa006500.88598317
50Chemical carcinogenesis_Homo sapiens_hsa052040.88583524
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85394318
52Tryptophan metabolism_Homo sapiens_hsa003800.83931764
53Fat digestion and absorption_Homo sapiens_hsa049750.83867006
54Rheumatoid arthritis_Homo sapiens_hsa053230.83297386
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82144930
56Spliceosome_Homo sapiens_hsa030400.82108651
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80418148
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.80262435
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79571141
60Olfactory transduction_Homo sapiens_hsa047400.78703188
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78072107
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78021849
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75899793
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.74661426
65RNA transport_Homo sapiens_hsa030130.74113802
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.72971091
67Sulfur relay system_Homo sapiens_hsa041220.70979573
68Metabolic pathways_Homo sapiens_hsa011000.70222215
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69233806
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64998293
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64088943
72Ether lipid metabolism_Homo sapiens_hsa005650.63949693
73Systemic lupus erythematosus_Homo sapiens_hsa053220.63186451
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61677271
75Regulation of autophagy_Homo sapiens_hsa041400.60760713
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59594702
77Selenocompound metabolism_Homo sapiens_hsa004500.57428364
78T cell receptor signaling pathway_Homo sapiens_hsa046600.57298359
79beta-Alanine metabolism_Homo sapiens_hsa004100.56925151
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56023719
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54193466
82Arginine and proline metabolism_Homo sapiens_hsa003300.52260804
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50777681
84Folate biosynthesis_Homo sapiens_hsa007900.48721856
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48287350
86Fatty acid elongation_Homo sapiens_hsa000620.46205283
87Collecting duct acid secretion_Homo sapiens_hsa049660.46027749
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.45668795
89Glutathione metabolism_Homo sapiens_hsa004800.44494898
90Vitamin digestion and absorption_Homo sapiens_hsa049770.43604454
91Taste transduction_Homo sapiens_hsa047420.36919949
92Fatty acid degradation_Homo sapiens_hsa000710.36796297
93Pyruvate metabolism_Homo sapiens_hsa006200.34684915
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33805968
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33710502
96Measles_Homo sapiens_hsa051620.33594779
97Viral myocarditis_Homo sapiens_hsa054160.32776367
98Mineral absorption_Homo sapiens_hsa049780.32695162
99Herpes simplex infection_Homo sapiens_hsa051680.31888414
100ABC transporters_Homo sapiens_hsa020100.31875903

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »