RPLP0P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.09116343
2signal peptide processing (GO:0006465)6.07269596
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.66925952
4ATP synthesis coupled proton transport (GO:0015986)5.58006439
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.58006439
6valine metabolic process (GO:0006573)5.50640346
7viral transcription (GO:0019083)5.32268308
8translational termination (GO:0006415)5.11200872
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.96572833
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.76268055
11prenylation (GO:0097354)4.75315714
12protein prenylation (GO:0018342)4.75315714
13protein targeting to ER (GO:0045047)4.73054755
14translational elongation (GO:0006414)4.72429625
15cotranslational protein targeting to membrane (GO:0006613)4.68248160
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.55320264
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.55320264
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.55263862
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45663582
20protein localization to endoplasmic reticulum (GO:0070972)4.43252499
21ribosomal small subunit biogenesis (GO:0042274)4.42003197
22multicellular organism reproduction (GO:0032504)4.35111243
23branched-chain amino acid catabolic process (GO:0009083)4.32471327
24rRNA modification (GO:0000154)4.16043498
25viral life cycle (GO:0019058)4.04267674
26protein complex biogenesis (GO:0070271)4.02494143
27translational initiation (GO:0006413)4.01679586
28sperm capacitation (GO:0048240)3.95676180
29ribosomal large subunit biogenesis (GO:0042273)3.93150157
30L-methionine salvage (GO:0071267)3.88720628
31L-methionine biosynthetic process (GO:0071265)3.88720628
32amino acid salvage (GO:0043102)3.88720628
33rRNA methylation (GO:0031167)3.81818960
34proteasome assembly (GO:0043248)3.77162809
35cellular protein complex disassembly (GO:0043624)3.76801396
36GTP biosynthetic process (GO:0006183)3.76530774
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75223111
38translation (GO:0006412)3.72722929
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70638262
40tachykinin receptor signaling pathway (GO:0007217)3.67081263
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66934394
42cytochrome complex assembly (GO:0017004)3.61951214
43respiratory chain complex IV assembly (GO:0008535)3.59276864
44oxidative phosphorylation (GO:0006119)3.55890694
45mitochondrial respiratory chain complex assembly (GO:0033108)3.54113543
46respiratory electron transport chain (GO:0022904)3.52491428
47branched-chain amino acid metabolic process (GO:0009081)3.50018823
48response to pheromone (GO:0019236)3.47535222
49electron transport chain (GO:0022900)3.47127978
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45905823
51protein-chromophore linkage (GO:0018298)3.43377084
52positive regulation of uterine smooth muscle contraction (GO:0070474)3.42581250
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42100651
54ATP biosynthetic process (GO:0006754)3.31227980
55cellular response to interferon-beta (GO:0035458)3.30845636
56chaperone-mediated protein transport (GO:0072321)3.30751036
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27595879
58UTP biosynthetic process (GO:0006228)3.19334912
59DNA deamination (GO:0045006)3.19226579
60maturation of SSU-rRNA (GO:0030490)3.15453863
61regulation of podosome assembly (GO:0071801)3.14258959
62DNA catabolic process, exonucleolytic (GO:0000738)3.13819975
63protein targeting to membrane (GO:0006612)3.11213990
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.10622163
65NADH dehydrogenase complex assembly (GO:0010257)3.10622163
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10622163
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.04493584
68DNA ligation (GO:0006266)3.04235649
69sulfur amino acid catabolic process (GO:0000098)2.99567144
70guanosine-containing compound biosynthetic process (GO:1901070)2.99350729
71UTP metabolic process (GO:0046051)2.98101441
72cardiolipin metabolic process (GO:0032048)2.97704639
73protein complex disassembly (GO:0043241)2.96906643
74mannosylation (GO:0097502)2.90834751
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90787205
76cellular component biogenesis (GO:0044085)2.86250965
77mRNA catabolic process (GO:0006402)2.86221317
78cytokinetic process (GO:0032506)2.85786259
79nucleoside diphosphate phosphorylation (GO:0006165)2.85678106
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84778875
81RNA destabilization (GO:0050779)2.84035290
82ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81913076
83regulation of cellular amino acid metabolic process (GO:0006521)2.81848031
84base-excision repair, AP site formation (GO:0006285)2.81783325
85macromolecular complex disassembly (GO:0032984)2.81255911
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81045294
87response to interferon-beta (GO:0035456)2.80309517
88hydrogen ion transmembrane transport (GO:1902600)2.78522310
89rhodopsin mediated signaling pathway (GO:0016056)2.77873463
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76543388
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76543388
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76543388
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74665606
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74665606
95nucleoside triphosphate biosynthetic process (GO:0009142)2.74470673
96formation of translation preinitiation complex (GO:0001731)2.72837978
97reproduction (GO:0000003)2.70997563
98RNA catabolic process (GO:0006401)2.70789431
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68089739
100water-soluble vitamin biosynthetic process (GO:0042364)2.67074120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.07583115
2ELF1_17652178_ChIP-ChIP_JURKAT_Human5.62538093
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.05462661
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34889439
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.32063101
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.06748644
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89757540
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.85567179
9ZNF274_21170338_ChIP-Seq_K562_Hela2.70722542
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64414544
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63699647
12VDR_22108803_ChIP-Seq_LS180_Human2.61069634
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60924835
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55403243
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52828123
16VDR_23849224_ChIP-Seq_CD4+_Human2.36568380
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35836069
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.21753706
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20958907
20FOXP3_21729870_ChIP-Seq_TREG_Human2.05235526
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.94672755
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90836262
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85046722
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79812838
25ELK1_19687146_ChIP-ChIP_HELA_Human1.74652970
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73107657
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.68018009
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.62409178
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53759691
30EWS_26573619_Chip-Seq_HEK293_Human1.53643774
31IGF1R_20145208_ChIP-Seq_DFB_Human1.52840433
32AR_20517297_ChIP-Seq_VCAP_Human1.47717373
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46079852
34AR_21572438_ChIP-Seq_LNCaP_Human1.43602109
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37440709
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36172948
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35478941
38TTF2_22483619_ChIP-Seq_HELA_Human1.34742445
39TP53_22573176_ChIP-Seq_HFKS_Human1.34621441
40E2F7_22180533_ChIP-Seq_HELA_Human1.28403738
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27004453
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26571325
43XRN2_22483619_ChIP-Seq_HELA_Human1.20749901
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19077781
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18633772
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18601294
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17911301
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17197412
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16785047
50MYC_18940864_ChIP-ChIP_HL60_Human1.15460921
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.15236138
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15236138
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15080821
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14815869
55NANOG_19829295_ChIP-Seq_ESCs_Human1.11342013
56SOX2_19829295_ChIP-Seq_ESCs_Human1.11342013
57TAF15_26573619_Chip-Seq_HEK293_Human1.09117891
58FOXH1_21741376_ChIP-Seq_EPCs_Human1.08973156
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08232893
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07468242
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07201520
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06644517
63FUS_26573619_Chip-Seq_HEK293_Human1.04055967
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02747624
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02441052
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02019058
67GATA3_26560356_Chip-Seq_TH2_Human1.01592329
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00589704
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99430236
70MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98061743
71NANOG_20526341_ChIP-Seq_ESCs_Human0.97401827
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96523448
73ER_23166858_ChIP-Seq_MCF-7_Human0.95186575
74CIITA_25753668_ChIP-Seq_RAJI_Human0.94746730
75NCOR_22424771_ChIP-Seq_293T_Human0.94485100
76GATA3_21878914_ChIP-Seq_MCF-7_Human0.94285557
77P300_19829295_ChIP-Seq_ESCs_Human0.94060557
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93660966
79DCP1A_22483619_ChIP-Seq_HELA_Human0.93349755
80E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91924395
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91654194
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90498056
83MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90435486
84IRF1_19129219_ChIP-ChIP_H3396_Human0.88876693
85BCL6_27268052_Chip-Seq_Bcells_Human0.88722705
86TAF2_19829295_ChIP-Seq_ESCs_Human0.87980264
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87792133
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.87559086
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87265358
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86439901
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86339032
92ERA_21632823_ChIP-Seq_H3396_Human0.84722062
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84513122
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82900912
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82499403
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81700422
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80829856
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.79822432
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79004701
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78471529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.28866045
2MP0002638_abnormal_pupillary_reflex5.79824654
3MP0003646_muscle_fatigue4.23979427
4MP0008058_abnormal_DNA_repair3.22492878
5MP0004145_abnormal_muscle_electrophysio3.08502841
6MP0000372_irregular_coat_pigmentation2.59083847
7MP0001764_abnormal_homeostasis2.58632747
8MP0008875_abnormal_xenobiotic_pharmacok2.34261478
9MP0008872_abnormal_physiological_respon2.04816087
10MP0005084_abnormal_gallbladder_morpholo2.01220227
11MP0005551_abnormal_eye_electrophysiolog1.96248867
12MP0001873_stomach_inflammation1.92490757
13MP0004147_increased_porphyrin_level1.90177519
14MP0004043_abnormal_pH_regulation1.89041084
15MP0005671_abnormal_response_to1.88035574
16MP0005645_abnormal_hypothalamus_physiol1.82156964
17MP0002837_dystrophic_cardiac_calcinosis1.72451612
18MP0001968_abnormal_touch/_nociception1.68953287
19MP0003806_abnormal_nucleotide_metabolis1.65390674
20MP0003186_abnormal_redox_activity1.55839614
21MP0003252_abnormal_bile_duct1.54888943
22MP0002102_abnormal_ear_morphology1.53971242
23MP0002736_abnormal_nociception_after1.51572356
24MP0009333_abnormal_splenocyte_physiolog1.51297073
25MP0005646_abnormal_pituitary_gland1.50214477
26MP0001986_abnormal_taste_sensitivity1.47804441
27MP0005253_abnormal_eye_physiology1.40425987
28MP0003718_maternal_effect1.39036674
29MP0006036_abnormal_mitochondrial_physio1.32835650
30MP0001835_abnormal_antigen_presentation1.32706435
31MP0003195_calcinosis1.31631033
32MP0005397_hematopoietic_system_phenotyp1.30708412
33MP0001545_abnormal_hematopoietic_system1.30708412
34MP0005167_abnormal_blood-brain_barrier1.25208356
35MP0003786_premature_aging1.24867106
36MP0004142_abnormal_muscle_tone1.24253746
37MP0008995_early_reproductive_senescence1.19375456
38MP0006072_abnormal_retinal_apoptosis1.15992969
39MP0001905_abnormal_dopamine_level1.15917588
40MP0005379_endocrine/exocrine_gland_phen1.15139136
41MP0001663_abnormal_digestive_system1.15087878
42MP0008775_abnormal_heart_ventricle1.10938867
43MP0004885_abnormal_endolymph1.10507130
44MP0001800_abnormal_humoral_immune1.09731302
45MP0002148_abnormal_hypersensitivity_rea1.09655017
46MP0008877_abnormal_DNA_methylation1.08813980
47MP0005085_abnormal_gallbladder_physiolo1.08270880
48MP0002095_abnormal_skin_pigmentation1.05194361
49MP0002928_abnormal_bile_duct1.04285736
50MP0002138_abnormal_hepatobiliary_system1.02566190
51MP0002822_catalepsy1.02445995
52MP0004215_abnormal_myocardial_fiber0.98792607
53MP0003693_abnormal_embryo_hatching0.97984495
54MP0009785_altered_susceptibility_to0.95941806
55MP0003724_increased_susceptibility_to0.95700402
56MP0004957_abnormal_blastocyst_morpholog0.95620757
57MP0006035_abnormal_mitochondrial_morpho0.94260371
58MP0002229_neurodegeneration0.94067842
59MP0003137_abnormal_impulse_conducting0.93197379
60MP0002163_abnormal_gland_morphology0.93092424
61MP0002277_abnormal_respiratory_mucosa0.88307850
62MP0005075_abnormal_melanosome_morpholog0.88226208
63MP0003638_abnormal_response/metabolism_0.87656094
64MP0006292_abnormal_olfactory_placode0.86501882
65MP0002876_abnormal_thyroid_physiology0.85202643
66MP0008004_abnormal_stomach_pH0.85054339
67MP0005195_abnormal_posterior_eye0.84235126
68MP0001348_abnormal_lacrimal_gland0.84122633
69MP0005636_abnormal_mineral_homeostasis0.83980555
70MP0002693_abnormal_pancreas_physiology0.83676559
71MP0005000_abnormal_immune_tolerance0.82824005
72MP0005389_reproductive_system_phenotype0.82815231
73MP0002234_abnormal_pharynx_morphology0.82747015
74MP0003950_abnormal_plasma_membrane0.82496408
75MP0004858_abnormal_nervous_system0.81968300
76MP0002452_abnormal_antigen_presenting0.81791989
77MP0001919_abnormal_reproductive_system0.81409032
78MP0002723_abnormal_immune_serum0.80820567
79MP0001502_abnormal_circadian_rhythm0.79440419
80MP0010329_abnormal_lipoprotein_level0.78542431
81MP0004133_heterotaxia0.76449115
82MP0002420_abnormal_adaptive_immunity0.75948285
83MP0001819_abnormal_immune_cell0.74340679
84MP0000685_abnormal_immune_system0.74201711
85MP0006082_CNS_inflammation0.74187896
86MP0001790_abnormal_immune_system0.73283896
87MP0005387_immune_system_phenotype0.73283896
88MP0002272_abnormal_nervous_system0.72385903
89MP0005381_digestive/alimentary_phenotyp0.72318742
90MP0002735_abnormal_chemical_nociception0.71736148
91MP0005365_abnormal_bile_salt0.70864432
92MP0001929_abnormal_gametogenesis0.70037570
93MP0009745_abnormal_behavioral_response0.69353902
94MP0000538_abnormal_urinary_bladder0.66050485
95MP0009643_abnormal_urine_homeostasis0.65831361
96MP0009046_muscle_twitch0.65346575
97MP0004019_abnormal_vitamin_homeostasis0.64182649
98MP0000639_abnormal_adrenal_gland0.63867653
99MP0002733_abnormal_thermal_nociception0.61937820
100MP0008789_abnormal_olfactory_epithelium0.59612936

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.71071290
2Abnormal rod and cone electroretinograms (HP:0008323)4.93297571
3Decreased central vision (HP:0007663)4.61996108
4Increased hepatocellular lipid droplets (HP:0006565)4.52749796
5Pendular nystagmus (HP:0012043)4.50273535
6Mitochondrial inheritance (HP:0001427)3.97975123
7Acute necrotizing encephalopathy (HP:0006965)3.97768787
8Lipid accumulation in hepatocytes (HP:0006561)3.96547811
9Attenuation of retinal blood vessels (HP:0007843)3.77413091
10Abnormal mitochondria in muscle tissue (HP:0008316)3.69683598
11Renal Fanconi syndrome (HP:0001994)3.63098170
12Increased CSF lactate (HP:0002490)3.56070857
13Cerebral hypomyelination (HP:0006808)3.34095235
14Progressive macrocephaly (HP:0004481)3.28069007
15Acute encephalopathy (HP:0006846)3.19982502
16Elevated erythrocyte sedimentation rate (HP:0003565)3.16384704
17Exertional dyspnea (HP:0002875)3.06225269
18Increased intramyocellular lipid droplets (HP:0012240)3.04104379
19Increased corneal curvature (HP:0100692)3.00179517
20Keratoconus (HP:0000563)3.00179517
21Pancreatic cysts (HP:0001737)2.99473082
22Optic disc pallor (HP:0000543)2.91106498
23Self-mutilation (HP:0000742)2.89466934
24Tinnitus (HP:0000360)2.89017544
25Hepatocellular necrosis (HP:0001404)2.88248035
26Carpal bone hypoplasia (HP:0001498)2.87577644
27Cerebral edema (HP:0002181)2.86608687
28Acanthocytosis (HP:0001927)2.85336444
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85291348
30Congenital stationary night blindness (HP:0007642)2.72715232
31Hepatic necrosis (HP:0002605)2.68104036
32True hermaphroditism (HP:0010459)2.65530971
33Personality changes (HP:0000751)2.64906004
34Pancreatic fibrosis (HP:0100732)2.64724086
35Constricted visual fields (HP:0001133)2.60244963
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.52963771
37Hyperphosphaturia (HP:0003109)2.47901090
38Asplenia (HP:0001746)2.47274762
39Type II lissencephaly (HP:0007260)2.46646113
40Increased muscle lipid content (HP:0009058)2.45218750
41Abnormal biliary tract physiology (HP:0012439)2.44148214
42Bile duct proliferation (HP:0001408)2.44148214
43Reticulocytopenia (HP:0001896)2.40747079
44Abnormality of urine glucose concentration (HP:0011016)2.38283920
45Glycosuria (HP:0003076)2.38283920
46Renal cortical cysts (HP:0000803)2.37486488
47Increased serum lactate (HP:0002151)2.30903799
48CNS hypomyelination (HP:0003429)2.30773414
49Hyperglycinemia (HP:0002154)2.27592408
50Delayed CNS myelination (HP:0002188)2.27149029
51Abolished electroretinogram (ERG) (HP:0000550)2.26648168
52Abnormal number of erythroid precursors (HP:0012131)2.25018741
53Acute hepatic failure (HP:0006554)2.24875246
54Irregular epiphyses (HP:0010582)2.23871761
55IgM deficiency (HP:0002850)2.23400668
56Lactic acidosis (HP:0003128)2.22420956
57Disproportionate short-trunk short stature (HP:0003521)2.22250762
58Abnormality of renal resorption (HP:0011038)2.20577086
59Severe combined immunodeficiency (HP:0004430)2.15231827
60Bilateral sensorineural hearing impairment (HP:0008619)2.15012646
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14146961
62Abnormality of cells of the erythroid lineage (HP:0012130)2.12719154
63Macrocytic anemia (HP:0001972)2.11166158
64Anencephaly (HP:0002323)2.10896120
65Respiratory failure (HP:0002878)2.09298858
66Disinhibition (HP:0000734)2.08913384
67Pallor (HP:0000980)2.04773004
68Choreoathetosis (HP:0001266)2.04769632
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01357218
70Premature ovarian failure (HP:0008209)2.00852928
71Dyskinesia (HP:0100660)2.00727453
72IgG deficiency (HP:0004315)1.99202599
73Intellectual disability, profound (HP:0002187)1.98677194
74Abnormality of fatty-acid metabolism (HP:0004359)1.98201148
75Gaze-evoked nystagmus (HP:0000640)1.96856283
76Respiratory difficulties (HP:0002880)1.95990182
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94422914
78Supernumerary spleens (HP:0009799)1.93514359
79Type 2 muscle fiber atrophy (HP:0003554)1.93073094
80Aplasia/hypoplasia of the uterus (HP:0008684)1.91821039
813-Methylglutaconic aciduria (HP:0003535)1.91186271
82Stenosis of the external auditory canal (HP:0000402)1.90741746
83Unsteady gait (HP:0002317)1.90430377
84Occipital encephalocele (HP:0002085)1.90029663
85Lethargy (HP:0001254)1.89426847
86Abnormality of alanine metabolism (HP:0010916)1.88870325
87Hyperalaninemia (HP:0003348)1.88870325
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88870325
89Chronic sinusitis (HP:0011109)1.86910474
90CNS demyelination (HP:0007305)1.86883959
91Cleft eyelid (HP:0000625)1.86172787
92Macular degeneration (HP:0000608)1.81736125
93Exercise intolerance (HP:0003546)1.81072469
94Alkalosis (HP:0001948)1.80084678
95Abnormal urine phosphate concentration (HP:0012599)1.79391570
96Lissencephaly (HP:0001339)1.76241465
97Psychosis (HP:0000709)1.74222344
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71734257
99Blindness (HP:0000618)1.71647779
100Abnormality of dentin (HP:0010299)1.69624945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.14559593
2MAP4K23.68878507
3RIPK42.82787556
4VRK22.71095860
5BCKDK2.70938892
6NEK12.54796095
7MST42.49294740
8TIE12.39245067
9TAOK32.37764073
10ADRBK22.24005281
11CDK192.23937328
12PBK2.04679064
13WNK32.02245704
14ZAK2.01579345
15PASK2.00432297
16MAP3K121.98330817
17TLK11.98270112
18GRK61.97574392
19TEC1.93583445
20GRK11.91480070
21TXK1.84654685
22STK38L1.72473970
23SIK31.70865078
24NUAK11.70569821
25OXSR11.68754798
26EIF2AK31.66802981
27CCNB11.63271067
28BUB11.60135856
29VRK11.59733044
30MAP4K11.49765196
31KDR1.40786436
32ITK1.40292518
33BMPR1B1.38531061
34MAP3K111.25343255
35TSSK61.21471814
36MKNK11.14785636
37STK391.13077581
38TGFBR11.10734330
39PLK31.09247403
40STK161.08884686
41SIK21.00682927
42INSRR0.98863371
43PHKG20.96224427
44PHKG10.96224427
45PRKCQ0.94621790
46TNK20.94317407
47TAF10.83264426
48BMPR20.82856273
49TESK20.80076495
50PLK40.79677722
51ACVR1B0.76215138
52IKBKB0.73440328
53KIT0.72864828
54CDK80.72487197
55SYK0.72231439
56RPS6KA50.69059753
57NEK90.68839883
58MYLK0.66906224
59MARK30.66253851
60PRKCG0.65388385
61WNK40.62467294
62FRK0.61583456
63MAPKAPK50.58386570
64BTK0.58123800
65LCK0.58017618
66PLK10.56788147
67ADRBK10.56524297
68OBSCN0.52207907
69NME10.50744068
70TBK10.49969431
71MAP2K60.49400931
72PRKACA0.49349043
73LRRK20.47444744
74LYN0.46389570
75DAPK10.45678585
76WEE10.44629756
77PRKCI0.43807618
78CSNK2A10.43010994
79FES0.41569290
80PINK10.41354946
81PIK3CG0.40746947
82SRPK10.39040428
83TNIK0.37663192
84CSNK2A20.37257570
85CDC70.35567946
86JAK30.35036059
87GRK50.34277337
88IKBKE0.33807241
89ALK0.33349981
90SIK10.32931790
91CSK0.32750559
92PRKCA0.31481677
93PLK20.30073784
94MAP3K140.29584536
95PRKCE0.29044465
96MUSK0.28191357
97ABL20.28012983
98PRKACG0.26892831
99RPS6KA40.26121529
100ERBB40.26112094

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.63513327
2Oxidative phosphorylation_Homo sapiens_hsa001903.53733278
3Proteasome_Homo sapiens_hsa030503.47397809
4Parkinsons disease_Homo sapiens_hsa050122.85419685
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.53005411
6Asthma_Homo sapiens_hsa053102.46953826
7Protein export_Homo sapiens_hsa030602.40472012
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10150653
9Primary immunodeficiency_Homo sapiens_hsa053402.09739187
10RNA polymerase_Homo sapiens_hsa030202.02574598
11Allograft rejection_Homo sapiens_hsa053301.98802017
12Autoimmune thyroid disease_Homo sapiens_hsa053201.96508451
13One carbon pool by folate_Homo sapiens_hsa006701.92423464
14Huntingtons disease_Homo sapiens_hsa050161.88100923
15Alzheimers disease_Homo sapiens_hsa050101.84361797
16Caffeine metabolism_Homo sapiens_hsa002321.81000505
17RNA degradation_Homo sapiens_hsa030181.78360928
18Basal transcription factors_Homo sapiens_hsa030221.77570860
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70521844
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68216509
21Phototransduction_Homo sapiens_hsa047441.55393443
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54782456
23Graft-versus-host disease_Homo sapiens_hsa053321.51184580
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49554198
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48657508
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48415687
27Sulfur metabolism_Homo sapiens_hsa009201.46086928
28Cardiac muscle contraction_Homo sapiens_hsa042601.43712400
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43095295
30Base excision repair_Homo sapiens_hsa034101.27930254
31Mismatch repair_Homo sapiens_hsa034301.26762970
32Type I diabetes mellitus_Homo sapiens_hsa049401.26446038
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24771892
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21911205
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21199478
36DNA replication_Homo sapiens_hsa030301.21173546
37Non-homologous end-joining_Homo sapiens_hsa034501.20130619
38Linoleic acid metabolism_Homo sapiens_hsa005911.19374614
39RNA transport_Homo sapiens_hsa030131.16062951
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11661317
41Selenocompound metabolism_Homo sapiens_hsa004501.09413255
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04383721
43Homologous recombination_Homo sapiens_hsa034401.03159145
44Purine metabolism_Homo sapiens_hsa002301.02740605
45Retinol metabolism_Homo sapiens_hsa008301.02177674
46Peroxisome_Homo sapiens_hsa041461.01638108
47Tryptophan metabolism_Homo sapiens_hsa003800.98819988
48Olfactory transduction_Homo sapiens_hsa047400.97978242
49Collecting duct acid secretion_Homo sapiens_hsa049660.95566810
50Propanoate metabolism_Homo sapiens_hsa006400.95194699
51Fanconi anemia pathway_Homo sapiens_hsa034600.93551504
52Pyrimidine metabolism_Homo sapiens_hsa002400.92957790
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.91878228
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91748823
55Chemical carcinogenesis_Homo sapiens_hsa052040.90207104
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87958203
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87094293
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79513850
59Antigen processing and presentation_Homo sapiens_hsa046120.79281707
60Rheumatoid arthritis_Homo sapiens_hsa053230.77579793
61Glutathione metabolism_Homo sapiens_hsa004800.76959575
62Arachidonic acid metabolism_Homo sapiens_hsa005900.76523002
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75923067
64Nucleotide excision repair_Homo sapiens_hsa034200.75653286
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73816154
66Nitrogen metabolism_Homo sapiens_hsa009100.69917853
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69263371
68Folate biosynthesis_Homo sapiens_hsa007900.68950043
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67562040
70Metabolic pathways_Homo sapiens_hsa011000.61632355
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.57397287
72Sulfur relay system_Homo sapiens_hsa041220.55722404
73Pyruvate metabolism_Homo sapiens_hsa006200.55363959
74Staphylococcus aureus infection_Homo sapiens_hsa051500.53906846
75Hematopoietic cell lineage_Homo sapiens_hsa046400.52603783
76Regulation of autophagy_Homo sapiens_hsa041400.52167772
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50410571
78Fatty acid elongation_Homo sapiens_hsa000620.48461041
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.48204413
80Butanoate metabolism_Homo sapiens_hsa006500.46543582
81Spliceosome_Homo sapiens_hsa030400.45183781
82ABC transporters_Homo sapiens_hsa020100.43595031
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.43067170
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41667185
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.41486301
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40944084
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40528865
88Viral myocarditis_Homo sapiens_hsa054160.38483367
89Morphine addiction_Homo sapiens_hsa050320.38287658
90Glycerolipid metabolism_Homo sapiens_hsa005610.37758407
91Fat digestion and absorption_Homo sapiens_hsa049750.37372860
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36977267
93Systemic lupus erythematosus_Homo sapiens_hsa053220.36805369
94Taste transduction_Homo sapiens_hsa047420.35416818
95Ether lipid metabolism_Homo sapiens_hsa005650.34629709
96Mineral absorption_Homo sapiens_hsa049780.33900674
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.33493774
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.29694367
99T cell receptor signaling pathway_Homo sapiens_hsa046600.28000753
100Pancreatic secretion_Homo sapiens_hsa049720.27681551

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