RPLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.71330862
2* viral transcription (GO:0019083)9.19108847
3* translational termination (GO:0006415)8.84852370
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.30716413
5ribosomal small subunit biogenesis (GO:0042274)7.90537995
6* translational elongation (GO:0006414)7.72020531
7ATP synthesis coupled proton transport (GO:0015986)7.38992529
8energy coupled proton transport, down electrochemical gradient (GO:0015985)7.38992529
9* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.34599631
10* protein targeting to ER (GO:0045047)7.17687474
11* cotranslational protein targeting to membrane (GO:0006613)7.13024576
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.97757818
13* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.85399524
14* cellular protein complex disassembly (GO:0043624)6.85098109
15* viral life cycle (GO:0019058)6.78015498
16* protein localization to endoplasmic reticulum (GO:0070972)6.68040497
17* translational initiation (GO:0006413)6.61817811
18* protein complex disassembly (GO:0043241)6.09913148
19maturation of SSU-rRNA (GO:0030490)5.89831099
20* macromolecular complex disassembly (GO:0032984)5.65327426
21respiratory electron transport chain (GO:0022904)5.42729833
22chaperone-mediated protein transport (GO:0072321)5.39017433
23ribosomal large subunit biogenesis (GO:0042273)5.34769673
24electron transport chain (GO:0022900)5.31290359
25establishment of protein localization to mitochondrial membrane (GO:0090151)5.24892701
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.22750382
27* nuclear-transcribed mRNA catabolic process (GO:0000956)4.89296700
28* protein targeting to membrane (GO:0006612)4.81580082
29DNA deamination (GO:0045006)4.74077925
30ncRNA 3-end processing (GO:0043628)4.72995320
31* mRNA catabolic process (GO:0006402)4.63924661
32ribonucleoprotein complex biogenesis (GO:0022613)4.54383731
33* translation (GO:0006412)4.48099254
34* RNA catabolic process (GO:0006401)4.41552677
35formation of translation preinitiation complex (GO:0001731)4.22652865
36ATP biosynthetic process (GO:0006754)4.07159457
37protein complex biogenesis (GO:0070271)4.01892715
38mitochondrial respiratory chain complex assembly (GO:0033108)3.89015798
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73247088
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.73247088
41NADH dehydrogenase complex assembly (GO:0010257)3.73247088
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.72660361
43termination of RNA polymerase III transcription (GO:0006386)3.72482467
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.72482467
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.72112273
46regulation of mitochondrial translation (GO:0070129)3.64559689
47inner mitochondrial membrane organization (GO:0007007)3.59503990
48DNA unwinding involved in DNA replication (GO:0006268)3.58900903
49folic acid-containing compound biosynthetic process (GO:0009396)3.54703086
50oxidative phosphorylation (GO:0006119)3.53380048
51hydrogen ion transmembrane transport (GO:1902600)3.49396889
52DNA strand elongation involved in DNA replication (GO:0006271)3.47741441
53rRNA modification (GO:0000154)3.45013312
54protein neddylation (GO:0045116)3.42918049
55rRNA processing (GO:0006364)3.42674226
56protein localization to kinetochore (GO:0034501)3.41272140
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.40240735
58proteasome assembly (GO:0043248)3.36904130
59negative regulation of RNA splicing (GO:0033119)3.36077953
60rRNA metabolic process (GO:0016072)3.31358584
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27874673
62DNA strand elongation (GO:0022616)3.27407185
63protein targeting to mitochondrion (GO:0006626)3.27232821
64* establishment of protein localization to membrane (GO:0090150)3.21872205
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21704388
66telomere maintenance via semi-conservative replication (GO:0032201)3.21083155
67IMP biosynthetic process (GO:0006188)3.14946845
68DNA replication initiation (GO:0006270)3.13467687
69purine nucleoside monophosphate biosynthetic process (GO:0009127)3.13312409
70purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.13312409
71establishment of protein localization to mitochondrion (GO:0072655)3.13017865
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12331851
73cellular component biogenesis (GO:0044085)3.11932825
74establishment of integrated proviral latency (GO:0075713)3.05271500
75ribosome assembly (GO:0042255)3.04884224
76ribosome biogenesis (GO:0042254)3.02525465
77nucleoside triphosphate biosynthetic process (GO:0009142)3.01783609
78protein localization to mitochondrion (GO:0070585)2.98268542
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98247639
80* establishment of protein localization to organelle (GO:0072594)2.95853780
81T cell apoptotic process (GO:0070231)2.95832194
82proton transport (GO:0015992)2.95621762
83protein localization to chromosome, centromeric region (GO:0071459)2.94827830
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94102954
85negative regulation of ligase activity (GO:0051352)2.94102954
86aerobic respiration (GO:0009060)2.93295112
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92872352
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89297318
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89297318
90hydrogen transport (GO:0006818)2.89063222
91* protein targeting (GO:0006605)2.88311665
92heterochromatin organization (GO:0070828)2.88177933
93chromatin remodeling at centromere (GO:0031055)2.86347339
94transcription-coupled nucleotide-excision repair (GO:0006283)2.85475448
95CENP-A containing nucleosome assembly (GO:0034080)2.84631413
96mitochondrial transport (GO:0006839)2.84553145
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84253762
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83019927
997-methylguanosine mRNA capping (GO:0006370)2.82838473
100intracellular protein transmembrane import (GO:0044743)2.80509649
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79217593
102IMP metabolic process (GO:0046040)2.78871282
1037-methylguanosine RNA capping (GO:0009452)2.75445722
104RNA capping (GO:0036260)2.75445722
105nucleoside monophosphate biosynthetic process (GO:0009124)2.73323973
106* cellular component disassembly (GO:0022411)2.71769725
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71683949
108ribonucleoside monophosphate biosynthetic process (GO:0009156)2.70757585
109mitotic nuclear envelope disassembly (GO:0007077)2.68793275
110telomere maintenance via recombination (GO:0000722)2.67733008
111DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67705117
112sequestering of actin monomers (GO:0042989)2.67345771
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67237555
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67237555
115cytochrome complex assembly (GO:0017004)2.65557379
116nucleobase biosynthetic process (GO:0046112)2.65110379
117DNA replication checkpoint (GO:0000076)2.63621741
118DNA replication-dependent nucleosome assembly (GO:0006335)2.62718639
119DNA replication-dependent nucleosome organization (GO:0034723)2.62718639
120negative regulation of erythrocyte differentiation (GO:0045647)2.62196417
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61691304
122lymphocyte apoptotic process (GO:0070227)2.59473725
123regulation of translational fidelity (GO:0006450)2.57513997
124regulation of protein heterodimerization activity (GO:0043497)2.55780664
125mitotic recombination (GO:0006312)2.52459118
126spliceosomal snRNP assembly (GO:0000387)2.52280270
127regulation of posttranscriptional gene silencing (GO:0060147)2.50554465
128regulation of gene silencing by miRNA (GO:0060964)2.50554465
129regulation of gene silencing by RNA (GO:0060966)2.50554465
130* gene expression (GO:0010467)2.48816974
131nuclear envelope disassembly (GO:0051081)2.47638742
132membrane disassembly (GO:0030397)2.47638742
133negative regulation of translational initiation (GO:0045947)2.47409892
134telomere maintenance via telomere lengthening (GO:0010833)2.42347508
135* protein localization to membrane (GO:0072657)2.40673950
1363-UTR-mediated mRNA stabilization (GO:0070935)2.39168170
137mitotic G1 DNA damage checkpoint (GO:0031571)2.38104298
138mRNA splicing, via spliceosome (GO:0000398)2.36576619
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.36576619
140RNA splicing, via transesterification reactions (GO:0000375)2.36274350
141pseudouridine synthesis (GO:0001522)2.36206562
142nucleobase-containing small molecule interconversion (GO:0015949)2.34069139
143ribonucleoprotein complex assembly (GO:0022618)2.33040763
144pteridine-containing compound biosynthetic process (GO:0042559)2.32827703
145antigen processing and presentation of endogenous antigen (GO:0019883)2.32482401
146regulation of histone H3-K9 methylation (GO:0051570)2.32208474
147nucleotide-excision repair, DNA gap filling (GO:0006297)2.31230564
148maternal placenta development (GO:0001893)2.29745980
149purine nucleobase biosynthetic process (GO:0009113)2.29240867
150termination of RNA polymerase II transcription (GO:0006369)2.28096936
151DNA duplex unwinding (GO:0032508)2.27316023
152DNA geometric change (GO:0032392)2.24466886
153ncRNA processing (GO:0034470)2.24084002
154negative regulation of mRNA processing (GO:0050686)2.23683147
155spliceosomal complex assembly (GO:0000245)2.23075678
156chromatin assembly (GO:0031497)2.21988771
157* protein localization to organelle (GO:0033365)2.20305687
158ribonucleoprotein complex subunit organization (GO:0071826)2.19590009
159regulation of spindle organization (GO:0090224)2.18993213
160chromatin assembly or disassembly (GO:0006333)2.18991440
161mitotic metaphase plate congression (GO:0007080)2.18463214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.26930639
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.08176243
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05026015
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28584488
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10723008
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96741272
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.94716915
8MYC_22102868_ChIP-Seq_BL_Human2.63106572
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.52830610
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48676870
11XRN2_22483619_ChIP-Seq_HELA_Human2.39315406
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36242698
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35771289
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29418797
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.26823112
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21029002
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.08682058
18VDR_21846776_ChIP-Seq_THP-1_Human2.07173555
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06376325
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.99068977
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99013944
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92783511
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.92173224
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89883558
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86276997
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81253420
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77863507
28VDR_23849224_ChIP-Seq_CD4+_Human1.74631811
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64860713
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62184748
31DCP1A_22483619_ChIP-Seq_HELA_Human1.61461231
32* TTF2_22483619_ChIP-Seq_HELA_Human1.59034028
33* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58247947
34* MYC_18940864_ChIP-ChIP_HL60_Human1.53915154
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.52187814
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51882496
37FOXP3_21729870_ChIP-Seq_TREG_Human1.49071745
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45662776
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44357255
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.44066062
41* GABP_19822575_ChIP-Seq_HepG2_Human1.44051623
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42270811
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41783557
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41586168
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40499871
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40268207
47CIITA_25753668_ChIP-Seq_RAJI_Human1.38987408
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.38974947
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37458753
50CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36973713
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34809656
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34707327
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.33212424
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32992292
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32270179
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31470050
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31153569
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30174428
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29487495
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28553390
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28416377
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.26967250
63MAF_26560356_Chip-Seq_TH1_Human1.26311428
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25255581
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23666281
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23257998
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22987179
68AR_21909140_ChIP-Seq_LNCAP_Human1.22980860
69* UTX_26944678_Chip-Seq_JUKART_Human1.22855376
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22843533
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22799246
72ZNF263_19887448_ChIP-Seq_K562_Human1.22734605
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21473093
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19781508
75KDM5A_27292631_Chip-Seq_BREAST_Human1.18948228
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18931702
77TCF7_22412390_ChIP-Seq_EML_Mouse1.17638807
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17529026
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16927975
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16853183
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14524355
82* VDR_24763502_ChIP-Seq_THP-1_Human1.14409238
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13509392
84SPI1_23547873_ChIP-Seq_NB4_Human1.13077982
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13030835
86ELK1_19687146_ChIP-ChIP_HELA_Human1.12643304
87* MAF_26560356_Chip-Seq_TH2_Human1.11931696
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11861671
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10081651
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.09667649
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08592723
92* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07406728
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07256289
94TFEB_21752829_ChIP-Seq_HELA_Human1.07042787
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06564070
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06445738
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06052587
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05940046
99ATF3_27146783_Chip-Seq_COLON_Human1.05785604
100* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02335707
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00488355
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00194699
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00169885
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00122489
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99454578
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99378912
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98053848
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97989229
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97733989
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96446683
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96384522
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96101676
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95811170
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.95025403
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.94795516
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.94136029
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92749341
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91925583
119* SCL_19346495_ChIP-Seq_HPC-7_Human0.90420479
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89511474
121KDM2B_26808549_Chip-Seq_DND41_Human0.88971386
122LXR_22292898_ChIP-Seq_THP-1_Human0.88310394
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.86377734
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84484444
125* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82618538
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82086014
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79958247
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.78280742
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73979944
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72230374
131* SOX2_16153702_ChIP-ChIP_HESCs_Human0.71405803
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71116356
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70127438
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.70127438
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70127438
136ELF5_23300383_ChIP-Seq_T47D_Human0.68677597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.03446207
2MP0004957_abnormal_blastocyst_morpholog3.41409636
3MP0003136_yellow_coat_color3.36247023
4MP0006292_abnormal_olfactory_placode3.19962448
5MP0002938_white_spotting3.15772978
6MP0003111_abnormal_nucleus_morphology2.73090540
7MP0010352_gastrointestinal_tract_polyps2.66749593
8MP0003077_abnormal_cell_cycle2.65927315
9MP0002396_abnormal_hematopoietic_system2.65326079
10MP0010094_abnormal_chromosome_stability2.51135688
11MP0004808_abnormal_hematopoietic_stem2.32470484
12MP0009379_abnormal_foot_pigmentation2.31042791
13MP0003705_abnormal_hypodermis_morpholog2.27525987
14MP0000490_abnormal_crypts_of2.24412675
15MP0002277_abnormal_respiratory_mucosa2.08026865
16MP0009333_abnormal_splenocyte_physiolog1.95171783
17MP0000372_irregular_coat_pigmentation1.92375896
18MP0008007_abnormal_cellular_replicative1.82930788
19MP0000685_abnormal_immune_system1.78861970
20MP0002638_abnormal_pupillary_reflex1.76280919
21MP0003763_abnormal_thymus_physiology1.76272029
22MP0000566_synostosis1.75978484
23MP0008995_early_reproductive_senescence1.75690906
24MP0006036_abnormal_mitochondrial_physio1.73602827
25MP0005397_hematopoietic_system_phenotyp1.72652257
26MP0001545_abnormal_hematopoietic_system1.72652257
27MP0000350_abnormal_cell_proliferation1.72579149
28MP0005076_abnormal_cell_differentiation1.71065876
29MP0001730_embryonic_growth_arrest1.70664920
30MP0001293_anophthalmia1.70150665
31MP0010307_abnormal_tumor_latency1.61759908
32MP0005023_abnormal_wound_healing1.61168593
33MP0001346_abnormal_lacrimal_gland1.61167686
34MP0003718_maternal_effect1.60127511
35MP0009278_abnormal_bone_marrow1.58919215
36MP0002398_abnormal_bone_marrow1.52059589
37MP0008058_abnormal_DNA_repair1.49446411
38MP0009840_abnormal_foam_cell1.46527221
39MP0003315_abnormal_perineum_morphology1.46346542
40MP0005075_abnormal_melanosome_morpholog1.45975643
41MP0000858_altered_metastatic_potential1.45971125
42MP0002722_abnormal_immune_system1.45905086
43MP0005408_hypopigmentation1.45610958
44MP0008932_abnormal_embryonic_tissue1.44298725
45MP0006054_spinal_hemorrhage1.44087806
46MP0000703_abnormal_thymus_morphology1.43297442
47MP0000049_abnormal_middle_ear1.43065704
48MP0002019_abnormal_tumor_incidence1.42390013
49MP0003567_abnormal_fetal_cardiomyocyte1.42228743
50MP0000689_abnormal_spleen_morphology1.35783307
51MP0003436_decreased_susceptibility_to1.35233466
52MP0002166_altered_tumor_susceptibility1.33613284
53MP0003300_gastrointestinal_ulcer1.32659849
54MP0001800_abnormal_humoral_immune1.32309173
55MP0004197_abnormal_fetal_growth/weight/1.32232193
56MP0010155_abnormal_intestine_physiology1.31665430
57MP0009697_abnormal_copulation1.29941371
58MP0005377_hearing/vestibular/ear_phenot1.29592485
59MP0003878_abnormal_ear_physiology1.29592485
60MP0000313_abnormal_cell_death1.28142648
61MP0008789_abnormal_olfactory_epithelium1.27922074
62MP0001835_abnormal_antigen_presentation1.27700124
63MP0002080_prenatal_lethality1.23831073
64MP0002429_abnormal_blood_cell1.22592530
65MP0000750_abnormal_muscle_regeneration1.22096027
66MP0002452_abnormal_antigen_presenting1.20468049
67MP0003123_paternal_imprinting1.20112965
68MP0001697_abnormal_embryo_size1.19959300
69MP0003938_abnormal_ear_development1.17966116
70MP0001286_abnormal_eye_development1.17840257
71MP0000477_abnormal_intestine_morphology1.17674445
72MP0003011_delayed_dark_adaptation1.17564341
73MP0008438_abnormal_cutaneous_collagen1.17440974
74MP0001873_stomach_inflammation1.16496497
75MP0002086_abnormal_extraembryonic_tissu1.16477966
76MP0002420_abnormal_adaptive_immunity1.16464197
77MP0000716_abnormal_immune_system1.15718588
78MP0001819_abnormal_immune_cell1.15313861
79MP0002405_respiratory_system_inflammati1.15164214
80MP0003303_peritoneal_inflammation1.15079971
81MP0003786_premature_aging1.14573870
82MP0002234_abnormal_pharynx_morphology1.14569912
83MP0002653_abnormal_ependyma_morphology1.14389662
84MP0003566_abnormal_cell_adhesion1.14217079
85MP0002249_abnormal_larynx_morphology1.13355741
86MP0001849_ear_inflammation1.12647690
87MP0001672_abnormal_embryogenesis/_devel1.11577644
88MP0005380_embryogenesis_phenotype1.11577644
89MP0009785_altered_susceptibility_to1.11361180
90MP0004142_abnormal_muscle_tone1.11194955
91MP0006035_abnormal_mitochondrial_morpho1.08417499
92MP0005084_abnormal_gallbladder_morpholo1.07677183
93MP0006072_abnormal_retinal_apoptosis1.07493273
94MP0010030_abnormal_orbit_morphology1.06902900
95MP0003984_embryonic_growth_retardation1.06594736
96MP0004947_skin_inflammation1.06414053
97MP0008057_abnormal_DNA_replication1.05942733
98MP0002088_abnormal_embryonic_growth/wei1.04628526
99MP0002697_abnormal_eye_size1.03100098
100MP0002723_abnormal_immune_serum1.02576136
101MP0005000_abnormal_immune_tolerance1.02513598
102MP0001881_abnormal_mammary_gland1.02494498
103MP0003866_abnormal_defecation1.02328065
104MP0002210_abnormal_sex_determination1.01830662
105MP0002085_abnormal_embryonic_tissue1.01209123
106MP0001529_abnormal_vocalization1.01195252
107MP0005025_abnormal_response_to0.99423353
108MP0000631_abnormal_neuroendocrine_gland0.98305144
109MP0002006_tumorigenesis0.98193805
110MP0005671_abnormal_response_to0.96735217
111MP0010234_abnormal_vibrissa_follicle0.96132043
112MP0002084_abnormal_developmental_patter0.94175286
113MP0001905_abnormal_dopamine_level0.93824059
114MP0000733_abnormal_muscle_development0.93516823
115MP0002877_abnormal_melanocyte_morpholog0.93366897
116MP0005174_abnormal_tail_pigmentation0.92972490
117MP0005501_abnormal_skin_physiology0.90356892
118MP0002132_abnormal_respiratory_system0.89890831
119MP0000465_gastrointestinal_hemorrhage0.88437572
120MP0002160_abnormal_reproductive_system0.88269715
121MP0002163_abnormal_gland_morphology0.88069521
122MP0001790_abnormal_immune_system0.87983610
123MP0005387_immune_system_phenotype0.87983610
124MP0009250_abnormal_appendicular_skeleto0.87429500
125MP0001764_abnormal_homeostasis0.85291941
126MP0000762_abnormal_tongue_morphology0.84870126
127MP0001485_abnormal_pinna_reflex0.82978212
128MP0001853_heart_inflammation0.81800062
129MP0005464_abnormal_platelet_physiology0.81274513
130MP0000358_abnormal_cell_content/0.81212114
131MP0003283_abnormal_digestive_organ0.79359445
132MP0003453_abnormal_keratinocyte_physiol0.78102455
133MP0001145_abnormal_male_reproductive0.77659201
134MP0005394_taste/olfaction_phenotype0.76614204
135MP0005499_abnormal_olfactory_system0.76614204
136MP0001845_abnormal_inflammatory_respons0.75928683
137MP0003806_abnormal_nucleotide_metabolis0.75150331
138MP0009053_abnormal_anal_canal0.74254386
139MP0002111_abnormal_tail_morphology0.73918747
140MP0003941_abnormal_skin_development0.72237869
141MP0003186_abnormal_redox_activity0.71881360
142MP0009931_abnormal_skin_appearance0.71686706
143MP0005171_absent_coat_pigmentation0.71632877
144MP0003448_altered_tumor_morphology0.71264661
145MP0000026_abnormal_inner_ear0.70869894
146MP0005275_abnormal_skin_tensile0.69987018
147MP0000653_abnormal_sex_gland0.69217632
148MP0002095_abnormal_skin_pigmentation0.68358196
149MP0003656_abnormal_erythrocyte_physiolo0.68199201
150MP0002932_abnormal_joint_morphology0.67189440
151MP0001929_abnormal_gametogenesis0.66344168
152MP0004133_heterotaxia0.65479626
153MP0005389_reproductive_system_phenotype0.62940634
154MP0008875_abnormal_xenobiotic_pharmacok0.59787120
155MP0005503_abnormal_tendon_morphology0.56389084
156MP0002092_abnormal_eye_morphology0.54112285
157MP0002282_abnormal_trachea_morphology0.53452474
158MP0002233_abnormal_nose_morphology0.53340505
159MP0005391_vision/eye_phenotype0.52841528
160MP0001663_abnormal_digestive_system0.52328924
161MP0001324_abnormal_eye_pigmentation0.52270042
162MP0003937_abnormal_limbs/digits/tail_de0.51493555
163MP0001919_abnormal_reproductive_system0.50370343
164MP0005381_digestive/alimentary_phenotyp0.48067305
165MP0002837_dystrophic_cardiac_calcinosis0.47587034

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.15279525
2Abnormal number of erythroid precursors (HP:0012131)7.40640094
3Reticulocytopenia (HP:0001896)7.11611617
4Acute necrotizing encephalopathy (HP:0006965)5.32276703
5Macrocytic anemia (HP:0001972)5.20482030
6Increased hepatocellular lipid droplets (HP:0006565)5.17908081
7Pallor (HP:0000980)5.09443425
8Mitochondrial inheritance (HP:0001427)5.05706382
9Abnormal mitochondria in muscle tissue (HP:0008316)4.96738271
10Thrombocytosis (HP:0001894)4.71456777
11Lipid accumulation in hepatocytes (HP:0006561)4.67831625
12Acute encephalopathy (HP:0006846)4.48688028
13Renal Fanconi syndrome (HP:0001994)4.29501941
14Increased CSF lactate (HP:0002490)4.26553659
15Hepatocellular necrosis (HP:0001404)4.25128692
16Progressive macrocephaly (HP:0004481)4.19654145
173-Methylglutaconic aciduria (HP:0003535)3.98797088
18Hepatic necrosis (HP:0002605)3.95237012
19Increased intramyocellular lipid droplets (HP:0012240)3.85123413
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.66667624
21Exertional dyspnea (HP:0002875)3.51046331
22Respiratory difficulties (HP:0002880)3.37213042
23Increased muscle lipid content (HP:0009058)3.33502976
24Abnormality of reticulocytes (HP:0004312)3.32554512
25Congenital, generalized hypertrichosis (HP:0004540)3.31742527
26Cerebral edema (HP:0002181)3.30015625
27Colon cancer (HP:0003003)3.25825328
28Protrusio acetabuli (HP:0003179)3.08904881
29Multiple enchondromatosis (HP:0005701)3.06204852
30Trismus (HP:0000211)3.04601041
31Exercise intolerance (HP:0003546)2.81601550
32Selective tooth agenesis (HP:0001592)2.78711956
33Abnormality of renal resorption (HP:0011038)2.76459035
34Aplastic anemia (HP:0001915)2.76010957
35Lactic acidosis (HP:0003128)2.75814318
36Septo-optic dysplasia (HP:0100842)2.70601217
37Partial duplication of thumb phalanx (HP:0009944)2.67128546
38Absent thumb (HP:0009777)2.65301173
39Respiratory failure (HP:0002878)2.64862297
40Increased serum lactate (HP:0002151)2.64704325
41Microretrognathia (HP:0000308)2.59453555
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57986483
43Increased density of long bones (HP:0006392)2.54085786
4411 pairs of ribs (HP:0000878)2.52498855
45Type I transferrin isoform profile (HP:0003642)2.50206905
46IgM deficiency (HP:0002850)2.44726673
47Leukodystrophy (HP:0002415)2.42248408
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41219059
49Elevated erythrocyte sedimentation rate (HP:0003565)2.39493845
50Optic disc pallor (HP:0000543)2.38461274
51Poikiloderma (HP:0001029)2.34694574
52Petechiae (HP:0000967)2.34484800
53Ankle contracture (HP:0006466)2.32618689
54Abnormality of the parietal bone (HP:0002696)2.31549835
55Triphalangeal thumb (HP:0001199)2.28983491
56Generalized aminoaciduria (HP:0002909)2.28144468
57Pancytopenia (HP:0001876)2.24692183
58Missing ribs (HP:0000921)2.17177315
59Depressed nasal ridge (HP:0000457)2.16242864
60Oral leukoplakia (HP:0002745)2.15477226
61Abnormality of T cell physiology (HP:0011840)2.15287027
62Rectal prolapse (HP:0002035)2.13567582
63Abnormality of urine glucose concentration (HP:0011016)2.11590373
64Glycosuria (HP:0003076)2.11590373
65Basal cell carcinoma (HP:0002671)2.11172514
66Cellulitis (HP:0100658)2.10939821
67Birth length less than 3rd percentile (HP:0003561)2.10036151
68Migraine (HP:0002076)2.06801506
69Microvesicular hepatic steatosis (HP:0001414)2.06634355
70Hyperphosphaturia (HP:0003109)2.04428920
71Gastrointestinal inflammation (HP:0004386)2.03030161
72Nasolacrimal duct obstruction (HP:0000579)2.02551965
73Rib fusion (HP:0000902)2.01889282
74Pustule (HP:0200039)2.00699750
75Sparse lateral eyebrow (HP:0005338)2.00413619
76Entropion (HP:0000621)2.00223390
77Nasal polyposis (HP:0100582)1.97489534
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97190073
79Hypoplasia of the radius (HP:0002984)1.96778960
80Absent septum pellucidum (HP:0001331)1.95820183
81Hypoplasia of the pons (HP:0012110)1.95361145
82Lethargy (HP:0001254)1.94913499
83Abnormality of T cells (HP:0002843)1.93841598
84Myelodysplasia (HP:0002863)1.93400704
85Neoplasm of the pancreas (HP:0002894)1.92671010
86Thick lower lip vermilion (HP:0000179)1.91528708
87Asplenia (HP:0001746)1.90793464
88Recurrent bronchitis (HP:0002837)1.90548830
89Abnormality of the pons (HP:0007361)1.87984415
90Chronic otitis media (HP:0000389)1.87406318
91Abnormality of the nasal mucosa (HP:0000433)1.87165164
92Duplication of thumb phalanx (HP:0009942)1.86010482
93Inflammation of the large intestine (HP:0002037)1.85423173
94Testicular atrophy (HP:0000029)1.84333139
95Ependymoma (HP:0002888)1.83058349
96Bicuspid aortic valve (HP:0001647)1.82805679
97Degeneration of anterior horn cells (HP:0002398)1.82750481
98Abnormality of the anterior horn cell (HP:0006802)1.82750481
99Abnormal hemoglobin (HP:0011902)1.81851480
100Breast hypoplasia (HP:0003187)1.81350724
101Maternal diabetes (HP:0009800)1.81104272
102Abnormality of the heme biosynthetic pathway (HP:0010472)1.80806172
103Methylmalonic acidemia (HP:0002912)1.79877067
104Broad palm (HP:0001169)1.78415819
105Colitis (HP:0002583)1.78367080
106Hyperacusis (HP:0010780)1.78009525
107Recurrent viral infections (HP:0004429)1.77608952
108Atresia of the external auditory canal (HP:0000413)1.76688230
109Abnormality of methionine metabolism (HP:0010901)1.76119663
110Spastic diplegia (HP:0001264)1.75769656
111Methylmalonic aciduria (HP:0012120)1.75602038
112Papilloma (HP:0012740)1.75553020
113Verrucae (HP:0200043)1.75553020
114Cleft eyelid (HP:0000625)1.74164475
115Genu recurvatum (HP:0002816)1.73834899
116Dicarboxylic aciduria (HP:0003215)1.72953093
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72953093
118Megaloblastic anemia (HP:0001889)1.72782514
119Cervical subluxation (HP:0003308)1.72316012
120Aplasia/Hypoplasia of the spleen (HP:0010451)1.72268163
121Prolonged bleeding time (HP:0003010)1.72162286
122Reduced antithrombin III activity (HP:0001976)1.71827430
123Concave nail (HP:0001598)1.71158652
124Slender long bone (HP:0003100)1.71108460
125Radial bowing (HP:0002986)1.70468117
126Woolly hair (HP:0002224)1.68467802
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68417213
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68417213
129Amniotic constriction ring (HP:0009775)1.68292325
130Abnormality of placental membranes (HP:0011409)1.68292325
131Meckel diverticulum (HP:0002245)1.68063220
132Abnormal platelet function (HP:0011869)1.67336555
133Impaired platelet aggregation (HP:0003540)1.67336555
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.66549408
135Ulnar bowing (HP:0003031)1.66327439
136Angiofibromas (HP:0010615)1.65977580
137Adenoma sebaceum (HP:0009720)1.65977580
138Panhypogammaglobulinemia (HP:0003139)1.65941185
139Overlapping toe (HP:0001845)1.65780139
140Progressive muscle weakness (HP:0003323)1.64334760
141Abnormal urine phosphate concentration (HP:0012599)1.64117096
142Renal tubular dysfunction (HP:0000124)1.63466944
143Sparse eyelashes (HP:0000653)1.63003613
144Abnormal protein glycosylation (HP:0012346)1.62885808
145Abnormal glycosylation (HP:0012345)1.62885808
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62885808
147Abnormal protein N-linked glycosylation (HP:0012347)1.62885808
148Recurrent fungal infections (HP:0002841)1.61117100
149Amaurosis fugax (HP:0100576)1.60818148
150Peritonitis (HP:0002586)1.60570861
151Increased serum ferritin (HP:0003281)1.60173521
152Rough bone trabeculation (HP:0100670)1.60040791
153Interstitial pulmonary disease (HP:0006530)1.60005966
154Cerebral aneurysm (HP:0004944)1.59968969
155Abnormality of the septum pellucidum (HP:0007375)1.59721782
156Glossoptosis (HP:0000162)1.59512363
157Abnormality of the renal collecting system (HP:0004742)1.59027569
158Abnormality of the calcaneus (HP:0008364)1.58286772
159Neutropenia (HP:0001875)1.57372210
160Abnormality of the ileum (HP:0001549)1.57131803
161Partial duplication of the phalanx of hand (HP:0009999)1.56100588
162Shallow orbits (HP:0000586)1.56089530
163Abnormal number of incisors (HP:0011064)1.55821844
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.55691765
165Stenosis of the external auditory canal (HP:0000402)1.55668126
166High pitched voice (HP:0001620)1.55602338
167Molar tooth sign on MRI (HP:0002419)1.55388078
168Abnormality of midbrain morphology (HP:0002418)1.55388078
169Squamous cell carcinoma (HP:0002860)1.55069442
170Carpal bone hypoplasia (HP:0001498)1.54085896
171Lymphoma (HP:0002665)1.53238809
172Biconcave vertebral bodies (HP:0004586)1.52927096
173Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52863344
174Vertebral hypoplasia (HP:0008417)1.52863344
175Bowed forearm bones (HP:0003956)1.49576168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.14771368
2NME25.27035227
3STK164.00818021
4EEF2K3.73352487
5NME13.39104644
6PKN22.99408212
7TRIB32.77044029
8MAP3K102.59862228
9ERN12.39510933
10BUB12.36766658
11LRRK22.34164691
12TAF12.27564465
13RPS6KB22.18881232
14MAP4K12.17092653
15SCYL22.09897430
16TESK22.09655992
17WEE12.05315735
18NEK21.99983405
19TLK11.92892124
20CDC71.91854018
21RPS6KA41.81018921
22PIM21.80845292
23ZAK1.61549111
24PBK1.57494797
25EPHB21.54851065
26PASK1.50896556
27MAP3K81.47187341
28FLT31.47143508
29CDK81.45791256
30EIF2AK11.45669557
31MST41.44211580
32NUAK11.35567975
33PAK41.35354722
34STK101.28644615
35TGFBR11.25864924
36DYRK21.25506969
37ILK1.24832073
38MAPK151.24171726
39CDK41.23698790
40AURKB1.23493414
41PIM11.20999802
42LATS21.20988575
43CDK71.20066279
44MAP3K111.15247198
45MAP2K31.15148400
46PLK41.14824127
47EPHA21.08355631
48DYRK31.06866441
49BTK1.04025824
50SMG10.99897131
51TYK20.98636302
52GRK60.98011354
53MOS0.97119345
54ZAP700.96556561
55PAK20.96294541
56PTK60.94700106
57PLK10.92982075
58TTK0.92246656
59CDK120.92213656
60MAPKAPK30.91850152
61KDR0.90589232
62ARAF0.89223108
63MUSK0.89201955
64MAP2K20.88998587
65PLK30.88580780
66TESK10.87494876
67AURKA0.86656051
68BCKDK0.86219133
69JAK30.84927556
70PAK10.82682751
71TTN0.82094363
72BMX0.81884434
73NEK10.81059922
74TBK10.80808756
75ABL20.79132303
76CDK60.76963529
77ALK0.76957641
78ATR0.76275293
79STK40.76015506
80MAP3K120.75865013
81TAOK30.71379544
82TSSK60.70044679
83SRPK10.67949888
84VRK10.67138934
85BRSK20.66876550
86BLK0.66512548
87TAOK10.60296820
88MAP3K30.58781179
89KIT0.58545742
90DAPK30.58518891
91ACVR1B0.57944867
92IKBKE0.56559125
93CSF1R0.56401391
94CDK190.55686780
95IKBKB0.54503149
96CHEK20.54250721
97CHEK10.53257021
98MTOR0.52857901
99STK240.52498102
100MKNK10.51859380
101CLK10.51641330
102RPS6KL10.48993909
103RPS6KC10.48993909
104RPS6KA10.48729475
105RPS6KA60.48487235
106TEC0.48140526
107BMPR1B0.47507603
108* CSNK2A20.47488602
109RPS6KA50.47425351
110INSRR0.46990098
111CDK30.46606891
112TXK0.46564864
113SYK0.46326683
114AKT20.45926692
115CCNB10.45031507
116PRKCI0.44815176
117IRAK40.44761457
118ADRBK20.43440317
119MAPKAPK20.42860746
120CDK90.41631157
121IRAK20.41513331
122CDK20.41447414
123CHUK0.40839650
124MAPKAPK50.40824748
125EIF2AK30.40607932
126BRSK10.40604755
127PNCK0.40443287
128BRAF0.38805308
129CSNK2A10.36846855
130GRK10.35874508
131MAPK110.35421540
132FGFR40.35109337
133MARK30.34509205
134ADRBK10.33746689
135MYLK0.30744043
136PRKCD0.30126559
137EIF2AK20.28891258
138MATK0.28794210
139PDK20.25108092
140CSNK1E0.23776591
141TAOK20.19535859

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.27975427
2Oxidative phosphorylation_Homo sapiens_hsa001904.89090189
3DNA replication_Homo sapiens_hsa030303.96739173
4Mismatch repair_Homo sapiens_hsa034303.01167062
5Alzheimers disease_Homo sapiens_hsa050102.82045331
6Spliceosome_Homo sapiens_hsa030402.79860239
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41967946
8Base excision repair_Homo sapiens_hsa034102.40776956
9One carbon pool by folate_Homo sapiens_hsa006702.30451621
10RNA transport_Homo sapiens_hsa030132.22686555
11Cardiac muscle contraction_Homo sapiens_hsa042602.14715068
12RNA polymerase_Homo sapiens_hsa030202.13352294
13Proteasome_Homo sapiens_hsa030502.08092522
14Nucleotide excision repair_Homo sapiens_hsa034202.03266449
15Pyrimidine metabolism_Homo sapiens_hsa002402.02065203
16Homologous recombination_Homo sapiens_hsa034401.97370732
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80860779
18Cell cycle_Homo sapiens_hsa041101.77813656
19Sulfur relay system_Homo sapiens_hsa041221.76714334
20p53 signaling pathway_Homo sapiens_hsa041151.56090038
21Antigen processing and presentation_Homo sapiens_hsa046121.47019303
22Systemic lupus erythematosus_Homo sapiens_hsa053221.36347669
23Primary immunodeficiency_Homo sapiens_hsa053401.29003515
24Pentose phosphate pathway_Homo sapiens_hsa000301.26430714
25RNA degradation_Homo sapiens_hsa030181.21065388
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18692406
27Herpes simplex infection_Homo sapiens_hsa051681.10367207
28Non-homologous end-joining_Homo sapiens_hsa034501.08642817
29mRNA surveillance pathway_Homo sapiens_hsa030151.05004494
30Thyroid cancer_Homo sapiens_hsa052161.03909683
31Chronic myeloid leukemia_Homo sapiens_hsa052201.03534906
32Viral carcinogenesis_Homo sapiens_hsa052031.02834297
33Acute myeloid leukemia_Homo sapiens_hsa052211.01336125
34Fanconi anemia pathway_Homo sapiens_hsa034600.96772661
35Small cell lung cancer_Homo sapiens_hsa052220.96209620
36Epstein-Barr virus infection_Homo sapiens_hsa051690.96116517
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.93950595
38HTLV-I infection_Homo sapiens_hsa051660.93730609
39Bladder cancer_Homo sapiens_hsa052190.91854733
40Apoptosis_Homo sapiens_hsa042100.90060134
41Legionellosis_Homo sapiens_hsa051340.87326106
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81557145
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79676088
44B cell receptor signaling pathway_Homo sapiens_hsa046620.77618431
45Purine metabolism_Homo sapiens_hsa002300.77417734
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.77238688
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74755856
48Folate biosynthesis_Homo sapiens_hsa007900.73300342
49Selenocompound metabolism_Homo sapiens_hsa004500.72949308
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72475254
51Leishmaniasis_Homo sapiens_hsa051400.71975017
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71026053
53Biosynthesis of amino acids_Homo sapiens_hsa012300.70518650
54Measles_Homo sapiens_hsa051620.68848176
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68372155
56N-Glycan biosynthesis_Homo sapiens_hsa005100.67929715
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67095618
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66720330
59Metabolic pathways_Homo sapiens_hsa011000.65228016
60Hepatitis B_Homo sapiens_hsa051610.64985090
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64505252
62Shigellosis_Homo sapiens_hsa051310.64210387
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63211149
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.63188746
65Basal transcription factors_Homo sapiens_hsa030220.62460285
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.61454137
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.61235658
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60699134
69Hematopoietic cell lineage_Homo sapiens_hsa046400.58028489
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57014923
71Vitamin digestion and absorption_Homo sapiens_hsa049770.56971308
72MicroRNAs in cancer_Homo sapiens_hsa052060.56391243
73Basal cell carcinoma_Homo sapiens_hsa052170.56101569
74HIF-1 signaling pathway_Homo sapiens_hsa040660.55842955
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53518552
76Pyruvate metabolism_Homo sapiens_hsa006200.53451317
77Toxoplasmosis_Homo sapiens_hsa051450.53082367
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.52548038
79Chemical carcinogenesis_Homo sapiens_hsa052040.52102329
80Proteoglycans in cancer_Homo sapiens_hsa052050.51501812
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51142252
82Carbon metabolism_Homo sapiens_hsa012000.50597931
83Collecting duct acid secretion_Homo sapiens_hsa049660.50201001
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.50007844
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48727787
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.48175330
87Influenza A_Homo sapiens_hsa051640.48174683
88Glutathione metabolism_Homo sapiens_hsa004800.48043196
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46465212
90Notch signaling pathway_Homo sapiens_hsa043300.46370895
91Non-small cell lung cancer_Homo sapiens_hsa052230.46169124
92Asthma_Homo sapiens_hsa053100.45727161
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44858041
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44167869
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43208350
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42679271
97Fructose and mannose metabolism_Homo sapiens_hsa000510.42044981
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41710640
99Alcoholism_Homo sapiens_hsa050340.41022026
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40382846
101Colorectal cancer_Homo sapiens_hsa052100.40131595
102Huntingtons disease_Homo sapiens_hsa050160.39849391
103Protein export_Homo sapiens_hsa030600.39786249
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39359439
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39038540
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39009439
107Malaria_Homo sapiens_hsa051440.38360501
108Parkinsons disease_Homo sapiens_hsa050120.38175219
109Osteoclast differentiation_Homo sapiens_hsa043800.37641826
110TGF-beta signaling pathway_Homo sapiens_hsa043500.37221121
111Fatty acid elongation_Homo sapiens_hsa000620.36118481
112Viral myocarditis_Homo sapiens_hsa054160.35847433
113T cell receptor signaling pathway_Homo sapiens_hsa046600.35796043
114Pathways in cancer_Homo sapiens_hsa052000.35340963
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35260263
116Peroxisome_Homo sapiens_hsa041460.33162609
117mTOR signaling pathway_Homo sapiens_hsa041500.32100172
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31134504
119Tyrosine metabolism_Homo sapiens_hsa003500.30957564
120TNF signaling pathway_Homo sapiens_hsa046680.30236047
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.29959432
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29640892
123Platelet activation_Homo sapiens_hsa046110.29447635
124Allograft rejection_Homo sapiens_hsa053300.28880845
125Sulfur metabolism_Homo sapiens_hsa009200.28507330
126Autoimmune thyroid disease_Homo sapiens_hsa053200.28056730
127Arachidonic acid metabolism_Homo sapiens_hsa005900.27214350
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.27146010
129Retinol metabolism_Homo sapiens_hsa008300.24895216
130Regulation of autophagy_Homo sapiens_hsa041400.24137666
131Propanoate metabolism_Homo sapiens_hsa006400.22334263
132Graft-versus-host disease_Homo sapiens_hsa053320.21541639
133Hedgehog signaling pathway_Homo sapiens_hsa043400.20659834
134Linoleic acid metabolism_Homo sapiens_hsa005910.20325696
135Nitrogen metabolism_Homo sapiens_hsa009100.18724754
136Phototransduction_Homo sapiens_hsa047440.15888760
137Rheumatoid arthritis_Homo sapiens_hsa053230.14250933
138Mineral absorption_Homo sapiens_hsa049780.11478123
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09522420
140Galactose metabolism_Homo sapiens_hsa000520.08203816
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06813856
142Caffeine metabolism_Homo sapiens_hsa002320.06577932
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05723435
144Wnt signaling pathway_Homo sapiens_hsa043100.03602826
145Arginine and proline metabolism_Homo sapiens_hsa003300.02244206
146Starch and sucrose metabolism_Homo sapiens_hsa005000.00876708
147Type I diabetes mellitus_Homo sapiens_hsa049400.00769839
148Oocyte meiosis_Homo sapiens_hsa041140.00242338

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