RPLP1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.43660812
2ribosomal small subunit biogenesis (GO:0042274)7.42634156
3ribosomal small subunit assembly (GO:0000028)7.32897566
4translational termination (GO:0006415)7.10664620
5maturation of SSU-rRNA (GO:0030490)6.96042230
6translational elongation (GO:0006414)6.26900822
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.16755488
8cotranslational protein targeting to membrane (GO:0006613)6.05883049
9protein targeting to ER (GO:0045047)6.02243984
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.77595347
11protein localization to endoplasmic reticulum (GO:0070972)5.63307954
12viral life cycle (GO:0019058)5.35383982
13cellular protein complex disassembly (GO:0043624)5.32930239
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.30758867
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.30758867
16chaperone-mediated protein transport (GO:0072321)5.24131291
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.18804796
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.11280800
19translational initiation (GO:0006413)4.96297588
20ATP synthesis coupled proton transport (GO:0015986)4.92449569
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.92449569
22ribosomal large subunit biogenesis (GO:0042273)4.91779244
23ribonucleoprotein complex biogenesis (GO:0022613)4.76015282
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.54531801
25protein complex disassembly (GO:0043241)4.49322534
26translation (GO:0006412)4.42073352
27cellular component biogenesis (GO:0044085)4.37398566
28protein complex biogenesis (GO:0070271)4.37387888
29macromolecular complex disassembly (GO:0032984)4.35529566
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.18515642
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10458123
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.10458123
33NADH dehydrogenase complex assembly (GO:0010257)4.10458123
34respiratory electron transport chain (GO:0022904)3.97508976
35mitochondrial respiratory chain complex assembly (GO:0033108)3.96197302
36protein targeting to membrane (GO:0006612)3.94645551
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.92057276
38electron transport chain (GO:0022900)3.91764787
39ribosome biogenesis (GO:0042254)3.85065864
40GTP biosynthetic process (GO:0006183)3.82303173
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.79700648
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.74191795
43regulation of mitochondrial translation (GO:0070129)3.67960666
44behavioral response to nicotine (GO:0035095)3.66043405
45cardiovascular system development (GO:0072358)3.63650577
46mRNA catabolic process (GO:0006402)3.55069278
47rRNA processing (GO:0006364)3.49349795
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45223346
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41926430
50rRNA metabolic process (GO:0016072)3.37420399
51pseudouridine synthesis (GO:0001522)3.33761805
52pyrimidine nucleotide catabolic process (GO:0006244)3.32979835
53kinetochore assembly (GO:0051382)3.31725983
54UTP biosynthetic process (GO:0006228)3.30618252
55protein-cofactor linkage (GO:0018065)3.29429463
56DNA damage response, detection of DNA damage (GO:0042769)3.29177358
57termination of RNA polymerase III transcription (GO:0006386)3.25659174
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.25659174
59protein targeting to mitochondrion (GO:0006626)3.24469477
60establishment of mitochondrion localization (GO:0051654)3.21809113
61rRNA modification (GO:0000154)3.19216303
62RNA catabolic process (GO:0006401)3.18817201
63proteasome assembly (GO:0043248)3.17800583
64base-excision repair, AP site formation (GO:0006285)3.11740532
65mitochondrion transport along microtubule (GO:0047497)3.07944246
66establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07944246
67ncRNA 3-end processing (GO:0043628)3.07831884
68guanosine-containing compound biosynthetic process (GO:1901070)3.06371956
69platelet dense granule organization (GO:0060155)3.05743321
70UTP metabolic process (GO:0046051)3.05452871
71establishment of protein localization to mitochondrion (GO:0072655)3.02575512
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00558425
73L-serine metabolic process (GO:0006563)2.99312068
74cell proliferation in forebrain (GO:0021846)2.97998127
75signal peptide processing (GO:0006465)2.96862809
76protein localization to mitochondrion (GO:0070585)2.96246346
77RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.96227196
78tRNA processing (GO:0008033)2.95999087
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95961945
80amino acid salvage (GO:0043102)2.95875960
81L-methionine salvage (GO:0071267)2.95875960
82L-methionine biosynthetic process (GO:0071265)2.95875960
83protein targeting (GO:0006605)2.85550193
84water-soluble vitamin biosynthetic process (GO:0042364)2.81739805
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.79679262
86DNA deamination (GO:0045006)2.79219605
87branched-chain amino acid catabolic process (GO:0009083)2.78541899
88single strand break repair (GO:0000012)2.78151324
89ncRNA processing (GO:0034470)2.76315675
90ATP biosynthetic process (GO:0006754)2.74744294
91sulfur amino acid catabolic process (GO:0000098)2.66533820
92kinetochore organization (GO:0051383)2.66334617
93establishment of protein localization to organelle (GO:0072594)2.66265517
94cytochrome complex assembly (GO:0017004)2.65516019
95hydrogen ion transmembrane transport (GO:1902600)2.64539665
96response to gravity (GO:0009629)2.62596354
97establishment of protein localization to membrane (GO:0090150)2.60373857
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59928192
99CTP biosynthetic process (GO:0006241)2.59135080
100CTP metabolic process (GO:0046036)2.59135080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.91970410
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.20730396
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68102255
4EZH2_22144423_ChIP-Seq_EOC_Human3.66777972
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63485798
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25949380
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.23774155
8VDR_22108803_ChIP-Seq_LS180_Human3.13280150
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99400814
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.95192348
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.79475605
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57699733
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55763157
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19353707
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11611058
16ZNF274_21170338_ChIP-Seq_K562_Hela2.10965580
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06482023
18FOXP3_21729870_ChIP-Seq_TREG_Human2.04368976
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02325804
20VDR_23849224_ChIP-Seq_CD4+_Human2.02136819
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96757538
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95658238
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95328979
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88873710
25TTF2_22483619_ChIP-Seq_HELA_Human1.76494117
26XRN2_22483619_ChIP-Seq_HELA_Human1.76278952
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75655538
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75559528
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74624547
30TP53_22573176_ChIP-Seq_HFKS_Human1.72127867
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.64766687
32IGF1R_20145208_ChIP-Seq_DFB_Human1.59259664
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55308202
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53232214
35GABP_19822575_ChIP-Seq_HepG2_Human1.52096466
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.51176946
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39925056
38MYC_18940864_ChIP-ChIP_HL60_Human1.39137659
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.39101072
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38159066
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33739012
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33524571
43EWS_26573619_Chip-Seq_HEK293_Human1.32974968
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30624722
45FUS_26573619_Chip-Seq_HEK293_Human1.29916033
46ELK1_19687146_ChIP-ChIP_HELA_Human1.29555990
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27818752
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24564723
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.24554660
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23364962
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22616282
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21106815
53IRF1_19129219_ChIP-ChIP_H3396_Human1.19754342
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18680018
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15898470
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15308707
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12558306
58ERA_21632823_ChIP-Seq_H3396_Human1.11938613
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11864905
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08308623
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.07947956
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07804774
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07115055
64DCP1A_22483619_ChIP-Seq_HELA_Human1.06883061
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.01203299
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.01002016
67KDM5A_27292631_Chip-Seq_BREAST_Human1.00844257
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98599455
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96657276
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95952994
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95253590
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92336336
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91575981
74NCOR_22424771_ChIP-Seq_293T_Human0.91365879
75NANOG_20526341_ChIP-Seq_ESCs_Human0.90973515
76MYC_19829295_ChIP-Seq_ESCs_Human0.90621826
77FOXP1_21924763_ChIP-Seq_HESCs_Human0.90084574
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.89226044
79TAF2_19829295_ChIP-Seq_ESCs_Human0.89030594
80RNF2_27304074_Chip-Seq_NSC_Mouse0.88594821
81AR_20517297_ChIP-Seq_VCAP_Human0.88186696
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87838515
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86801611
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85782810
85SOX2_19829295_ChIP-Seq_ESCs_Human0.85491015
86NANOG_19829295_ChIP-Seq_ESCs_Human0.85491015
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.85394745
88ERG_20517297_ChIP-Seq_VCAP_Human0.83557033
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83305269
90REST_21632747_ChIP-Seq_MESCs_Mouse0.83090483
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83034722
92BCL6_27268052_Chip-Seq_Bcells_Human0.81349305
93CTCF_20526341_ChIP-Seq_ESCs_Human0.80877437
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80379243
95JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80262083
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79964602
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.79477686
98STAT1_20625510_ChIP-Seq_HELA_Human0.79459043
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79385521
100P53_21459846_ChIP-Seq_SAOS-2_Human0.78389713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.34045014
2MP0006292_abnormal_olfactory_placode4.37919939
3MP0000372_irregular_coat_pigmentation3.74879163
4MP0003136_yellow_coat_color3.25416137
5MP0003646_muscle_fatigue3.01104214
6MP0002736_abnormal_nociception_after2.85843567
7MP0004145_abnormal_muscle_electrophysio2.54284238
8MP0001968_abnormal_touch/_nociception2.53011816
9MP0002163_abnormal_gland_morphology2.43761140
10MP0002095_abnormal_skin_pigmentation2.42791226
11MP0002938_white_spotting2.07472137
12MP0008789_abnormal_olfactory_epithelium1.99552349
13MP0001293_anophthalmia1.95978924
14MP0003880_abnormal_central_pattern1.91840343
15MP0002102_abnormal_ear_morphology1.85938473
16MP0005551_abnormal_eye_electrophysiolog1.80652287
17MP0005670_abnormal_white_adipose1.74504134
18MP0005646_abnormal_pituitary_gland1.73718510
19MP0004885_abnormal_endolymph1.72704726
20MP0000631_abnormal_neuroendocrine_gland1.71158689
21MP0002638_abnormal_pupillary_reflex1.69724254
22MP0000049_abnormal_middle_ear1.68693150
23MP0004142_abnormal_muscle_tone1.64939483
24MP0008877_abnormal_DNA_methylation1.64591186
25MP0006072_abnormal_retinal_apoptosis1.59971903
26MP0001485_abnormal_pinna_reflex1.55714842
27MP0003186_abnormal_redox_activity1.50498041
28MP0008872_abnormal_physiological_respon1.48065898
29MP0004133_heterotaxia1.46134202
30MP0003123_paternal_imprinting1.44571767
31MP0005499_abnormal_olfactory_system1.41796146
32MP0005394_taste/olfaction_phenotype1.41796146
33MP0008875_abnormal_xenobiotic_pharmacok1.40002800
34MP0003937_abnormal_limbs/digits/tail_de1.37081936
35MP0001502_abnormal_circadian_rhythm1.34247154
36MP0008058_abnormal_DNA_repair1.25871490
37MP0002160_abnormal_reproductive_system1.21381340
38MP0009250_abnormal_appendicular_skeleto1.21233876
39MP0006276_abnormal_autonomic_nervous1.21174544
40MP0002234_abnormal_pharynx_morphology1.20002415
41MP0000647_abnormal_sebaceous_gland1.19341468
42MP0004147_increased_porphyrin_level1.19032092
43MP0002277_abnormal_respiratory_mucosa1.14818119
44MP0009745_abnormal_behavioral_response1.14383863
45MP0005174_abnormal_tail_pigmentation1.12806466
46MP0005253_abnormal_eye_physiology1.08747718
47MP0003122_maternal_imprinting1.08449374
48MP0001986_abnormal_taste_sensitivity1.08339308
49MP0008995_early_reproductive_senescence1.05511775
50MP0001529_abnormal_vocalization1.05274932
51MP0001486_abnormal_startle_reflex1.05130408
52MP0002837_dystrophic_cardiac_calcinosis1.04461524
53MP0005075_abnormal_melanosome_morpholog1.03911020
54MP0005195_abnormal_posterior_eye1.03872899
55MP0005389_reproductive_system_phenotype1.03835589
56MP0009053_abnormal_anal_canal1.03331231
57MP0005645_abnormal_hypothalamus_physiol0.99116205
58MP0005379_endocrine/exocrine_gland_phen0.96890478
59MP0002272_abnormal_nervous_system0.96858707
60MP0000026_abnormal_inner_ear0.96813913
61MP0009046_muscle_twitch0.96387398
62MP0000566_synostosis0.93199651
63MP0001764_abnormal_homeostasis0.93095315
64MP0002557_abnormal_social/conspecific_i0.92340250
65MP0002876_abnormal_thyroid_physiology0.92222608
66MP0001286_abnormal_eye_development0.89561845
67MP0002249_abnormal_larynx_morphology0.89012708
68MP0001963_abnormal_hearing_physiology0.88902103
69MP0001905_abnormal_dopamine_level0.88851582
70MP0002210_abnormal_sex_determination0.86270844
71MP0003787_abnormal_imprinting0.85772929
72MP0003183_abnormal_peptide_metabolism0.85701155
73MP0001270_distended_abdomen0.85222674
74MP0006036_abnormal_mitochondrial_physio0.85087054
75MP0003755_abnormal_palate_morphology0.84926546
76MP0010030_abnormal_orbit_morphology0.83590909
77MP0003942_abnormal_urinary_system0.83351959
78MP0003878_abnormal_ear_physiology0.82763275
79MP0005377_hearing/vestibular/ear_phenot0.82763275
80MP0002752_abnormal_somatic_nervous0.80835851
81MP0002233_abnormal_nose_morphology0.80657687
82MP0005391_vision/eye_phenotype0.80237132
83MP0003718_maternal_effect0.80155763
84MP0000778_abnormal_nervous_system0.79279816
85MP0001919_abnormal_reproductive_system0.78098557
86MP0003938_abnormal_ear_development0.77792051
87MP0003011_delayed_dark_adaptation0.77507904
88MP0002733_abnormal_thermal_nociception0.76874870
89MP0003936_abnormal_reproductive_system0.74332553
90MP0003121_genomic_imprinting0.73851516
91MP0000427_abnormal_hair_cycle0.73821270
92MP0000534_abnormal_ureter_morphology0.73090006
93MP0002254_reproductive_system_inflammat0.72761984
94MP0005360_urolithiasis0.70929953
95MP0002109_abnormal_limb_morphology0.70290666
96MP0001324_abnormal_eye_pigmentation0.69094304
97MP0002697_abnormal_eye_size0.68496651
98MP0002132_abnormal_respiratory_system0.68265756
99MP0005636_abnormal_mineral_homeostasis0.67558090
100MP0002067_abnormal_sensory_capabilities0.67195810

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.94160931
2Acute necrotizing encephalopathy (HP:0006965)4.89432401
3Pendular nystagmus (HP:0012043)4.43987987
4Acute encephalopathy (HP:0006846)4.40676760
5Abnormal mitochondria in muscle tissue (HP:0008316)4.29469989
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.28528902
7Progressive macrocephaly (HP:0004481)3.98932375
8Congenital stationary night blindness (HP:0007642)3.79096979
9Hyperglycinemia (HP:0002154)3.74072724
10Mitochondrial inheritance (HP:0001427)3.63277211
11Decreased central vision (HP:0007663)3.55074863
12Macrocytic anemia (HP:0001972)3.46188532
13Increased CSF lactate (HP:0002490)3.43212785
14Abnormality of alanine metabolism (HP:0010916)3.35052717
15Hyperalaninemia (HP:0003348)3.35052717
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35052717
17Abnormality of cells of the erythroid lineage (HP:0012130)3.11331998
18Increased corneal curvature (HP:0100692)3.06176615
19Keratoconus (HP:0000563)3.06176615
20Abnormal rod and cone electroretinograms (HP:0008323)3.04385052
21Cerebral edema (HP:0002181)2.97382666
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.95226400
23Abnormality of midbrain morphology (HP:0002418)2.93351617
24Molar tooth sign on MRI (HP:0002419)2.93351617
25Colon cancer (HP:0003003)2.90079392
263-Methylglutaconic aciduria (HP:0003535)2.85936643
27Optic disc pallor (HP:0000543)2.81642411
28Pancreatic cysts (HP:0001737)2.80247152
29Stenosis of the external auditory canal (HP:0000402)2.75240577
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.73135069
31True hermaphroditism (HP:0010459)2.69543834
32Hepatocellular necrosis (HP:0001404)2.69216603
33Pallor (HP:0000980)2.68892470
34Absent thumb (HP:0009777)2.64560482
35Pancreatic fibrosis (HP:0100732)2.61515845
36Anencephaly (HP:0002323)2.58705424
37Delayed CNS myelination (HP:0002188)2.57815003
38Constricted visual fields (HP:0001133)2.55144430
39Nephronophthisis (HP:0000090)2.49838865
40Hepatic necrosis (HP:0002605)2.44935921
41Increased serum lactate (HP:0002151)2.44109425
42Septo-optic dysplasia (HP:0100842)2.42654790
43Abnormality of serum amino acid levels (HP:0003112)2.38694557
44Abnormal drinking behavior (HP:0030082)2.31360274
45Polydipsia (HP:0001959)2.31360274
46Lactic acidosis (HP:0003128)2.29617129
47Abnormal number of erythroid precursors (HP:0012131)2.29456982
48Occipital encephalocele (HP:0002085)2.27021601
49Maternal diabetes (HP:0009800)2.21927441
50Abnormality of the labia minora (HP:0012880)2.21362540
51Abnormality of the middle phalanges of the toes (HP:0010183)2.16872731
52Lethargy (HP:0001254)2.15869787
53Hypoplasia of the radius (HP:0002984)2.14669926
54Type 2 muscle fiber atrophy (HP:0003554)2.14058432
55Medial flaring of the eyebrow (HP:0010747)2.12262458
56Type II lissencephaly (HP:0007260)2.12164090
57Cerebral hypomyelination (HP:0006808)2.10162845
58Concave nail (HP:0001598)2.06559043
59Exercise intolerance (HP:0003546)2.04068955
60Attenuation of retinal blood vessels (HP:0007843)2.03792827
61Respiratory failure (HP:0002878)2.03596367
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00669414
63Abolished electroretinogram (ERG) (HP:0000550)1.99986480
64Abnormality of the renal medulla (HP:0100957)1.99933446
65Increased hepatocellular lipid droplets (HP:0006565)1.99337270
66Abnormality of serine family amino acid metabolism (HP:0010894)1.97888705
67Abnormality of glycine metabolism (HP:0010895)1.97888705
68Optic nerve hypoplasia (HP:0000609)1.96851449
69Asplenia (HP:0001746)1.95698504
70Methylmalonic acidemia (HP:0002912)1.95475410
71Aplasia/Hypoplasia of the spleen (HP:0010451)1.95427657
72Palpebral edema (HP:0100540)1.93962852
73Oligodactyly (hands) (HP:0001180)1.90563512
74Absent phalangeal crease (HP:0006109)1.89416584
75Leukodystrophy (HP:0002415)1.87676313
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86931667
77Supernumerary spleens (HP:0009799)1.84705885
78Testicular atrophy (HP:0000029)1.84614359
79Methylmalonic aciduria (HP:0012120)1.84347018
80Oligomenorrhea (HP:0000876)1.83969103
81Forearm undergrowth (HP:0009821)1.82256862
82Short tibia (HP:0005736)1.79540164
83Muscle fiber atrophy (HP:0100295)1.79238287
84Cleft eyelid (HP:0000625)1.78781657
85Optic nerve coloboma (HP:0000588)1.78744421
86Chorioretinal atrophy (HP:0000533)1.78245422
87Congenital sensorineural hearing impairment (HP:0008527)1.77508188
88Postaxial foot polydactyly (HP:0001830)1.75466471
89Ectopic kidney (HP:0000086)1.75075829
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74859629
91Lipid accumulation in hepatocytes (HP:0006561)1.71620791
92Hypoplasia of the ulna (HP:0003022)1.71536468
93Fibular aplasia (HP:0002990)1.71366202
94Partial duplication of thumb phalanx (HP:0009944)1.71154783
95Triphalangeal thumb (HP:0001199)1.71112427
96Abnormality of the phalanges of the hallux (HP:0010057)1.71013705
97Polyuria (HP:0000103)1.70760383
98Blindness (HP:0000618)1.70099098
99Symphalangism affecting the phalanges of the hand (HP:0009773)1.70071287
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.67659420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.98233162
2NME23.86980244
3WNK43.08053443
4TESK22.81596621
5GRK12.73987608
6STK162.68039263
7WNK32.50598312
8NUAK12.42807852
9DYRK22.21701589
10EPHA42.12451794
11BCKDK2.07726511
12FRK2.05848881
13VRK21.95995003
14TLK11.88958551
15PINK11.84315471
16ZAK1.73251399
17PDK21.65079398
18PHKG11.62927769
19PHKG21.62927769
20CDK191.59440919
21TRIM281.54336494
22CDC71.50658419
23STK391.47890545
24PIK3CA1.44010064
25ADRBK21.30783200
26SRPK11.24866169
27ABL21.22177511
28MAPK131.19770674
29OBSCN1.19538732
30MAP2K71.16342643
31MAP3K111.15078912
32INSRR1.11729344
33LRRK21.11135663
34CAMK11.10213284
35TIE11.09924961
36MAP3K41.07250859
37PRKCI1.02390020
38AURKA1.01266197
39PRKCG0.97980679
40NEK20.97858730
41MARK30.93147295
42CASK0.91403417
43BMPR1B0.88934158
44WNK10.88752502
45OXSR10.87860145
46PNCK0.86083566
47RPS6KA50.85469523
48CSNK1G20.84113003
49KDR0.84077848
50EPHB20.83554213
51PAK30.82883320
52BUB10.80493232
53NTRK20.78279155
54CSNK1G30.72942460
55PRKCQ0.72240776
56SIK20.71562685
57CSNK2A20.69440645
58PRKACA0.68613416
59CAMKK20.68471431
60NEK10.67401537
61AURKB0.66042108
62RPS6KB20.65324403
63VRK10.65227965
64MKNK20.65058078
65ACVR1B0.64722744
66PLK10.64186307
67CAMK1G0.63634767
68TAF10.62762920
69CAMK2D0.62599519
70CSNK2A10.60981813
71PBK0.60595421
72TEC0.60408363
73PLK40.58554688
74CSNK1A10.57912143
75RPS6KB10.57736514
76PRKCE0.57353117
77DAPK20.55668200
78ADRBK10.55177605
79CSNK1G10.54285795
80JAK30.52391314
81CHEK20.51401025
82LIMK10.50935777
83MKNK10.49062199
84PLK20.48182185
85CAMK2G0.46285150
86CSNK1E0.46032076
87MARK10.45532364
88MAP4K10.44204703
89CSNK1A1L0.43946379
90PRKAA20.43800618
91NME10.42255815
92CCNB10.42039667
93PLK30.40166911
94MUSK0.37480533
95PRKCA0.36513642
96RPS6KA60.35611258
97PRKACB0.35559526
98CAMK1D0.35192394
99RPS6KA40.34984527
100PASK0.34377005

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.50435682
2Oxidative phosphorylation_Homo sapiens_hsa001904.11553607
3Parkinsons disease_Homo sapiens_hsa050123.32252363
4Sulfur relay system_Homo sapiens_hsa041223.15192061
5RNA polymerase_Homo sapiens_hsa030202.61464644
6Huntingtons disease_Homo sapiens_hsa050162.37557764
7Alzheimers disease_Homo sapiens_hsa050102.20256863
8Proteasome_Homo sapiens_hsa030502.18412060
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11500678
10Protein export_Homo sapiens_hsa030602.09125955
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06802703
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99615089
13Asthma_Homo sapiens_hsa053101.90408096
14Cardiac muscle contraction_Homo sapiens_hsa042601.83683973
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78665260
16One carbon pool by folate_Homo sapiens_hsa006701.74473005
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63903803
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63253600
19Homologous recombination_Homo sapiens_hsa034401.59201122
20RNA degradation_Homo sapiens_hsa030181.58968333
21Phototransduction_Homo sapiens_hsa047441.52764317
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.45613553
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.44557004
24Basal transcription factors_Homo sapiens_hsa030221.43899456
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36554140
26Allograft rejection_Homo sapiens_hsa053301.28969458
27Linoleic acid metabolism_Homo sapiens_hsa005911.26579583
28Pyrimidine metabolism_Homo sapiens_hsa002401.22815596
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21509006
30Fanconi anemia pathway_Homo sapiens_hsa034601.17496966
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16168183
32Autoimmune thyroid disease_Homo sapiens_hsa053201.15175645
33Propanoate metabolism_Homo sapiens_hsa006401.12983680
34Selenocompound metabolism_Homo sapiens_hsa004501.09169295
35Base excision repair_Homo sapiens_hsa034101.05091945
36Olfactory transduction_Homo sapiens_hsa047401.03917243
37Nitrogen metabolism_Homo sapiens_hsa009101.03420283
38Spliceosome_Homo sapiens_hsa030401.03129935
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00332084
40Collecting duct acid secretion_Homo sapiens_hsa049660.99470148
41RNA transport_Homo sapiens_hsa030130.99419305
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98302478
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.90768247
44Caffeine metabolism_Homo sapiens_hsa002320.90658317
45Tryptophan metabolism_Homo sapiens_hsa003800.88765618
46Graft-versus-host disease_Homo sapiens_hsa053320.87713563
47Butanoate metabolism_Homo sapiens_hsa006500.85655291
48Purine metabolism_Homo sapiens_hsa002300.82751800
49Sulfur metabolism_Homo sapiens_hsa009200.82585079
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81226331
51Retinol metabolism_Homo sapiens_hsa008300.75480060
52Regulation of autophagy_Homo sapiens_hsa041400.75348084
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74443483
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74383356
55Metabolic pathways_Homo sapiens_hsa011000.72072567
56Type I diabetes mellitus_Homo sapiens_hsa049400.67135741
57Nicotine addiction_Homo sapiens_hsa050330.65854378
58Morphine addiction_Homo sapiens_hsa050320.65690268
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64666199
60Folate biosynthesis_Homo sapiens_hsa007900.64620345
61Arachidonic acid metabolism_Homo sapiens_hsa005900.64108976
62Arginine and proline metabolism_Homo sapiens_hsa003300.63624497
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62095461
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61511846
65Ether lipid metabolism_Homo sapiens_hsa005650.59710692
66Peroxisome_Homo sapiens_hsa041460.59117449
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.58390149
68Non-homologous end-joining_Homo sapiens_hsa034500.56124139
69DNA replication_Homo sapiens_hsa030300.55784372
70Vitamin B6 metabolism_Homo sapiens_hsa007500.55526444
71beta-Alanine metabolism_Homo sapiens_hsa004100.55218350
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54600483
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52725789
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51213911
75Fat digestion and absorption_Homo sapiens_hsa049750.50560926
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.48709176
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48220155
78Nucleotide excision repair_Homo sapiens_hsa034200.47193350
79Rheumatoid arthritis_Homo sapiens_hsa053230.46868488
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.45849245
81Fatty acid degradation_Homo sapiens_hsa000710.44766711
82Arginine biosynthesis_Homo sapiens_hsa002200.41761560
83Primary immunodeficiency_Homo sapiens_hsa053400.41099391
84Chemical carcinogenesis_Homo sapiens_hsa052040.37558496
85Tyrosine metabolism_Homo sapiens_hsa003500.37244930
86Taste transduction_Homo sapiens_hsa047420.36794015
87GABAergic synapse_Homo sapiens_hsa047270.35643075
88Insulin secretion_Homo sapiens_hsa049110.35618119
89Glutathione metabolism_Homo sapiens_hsa004800.35287075
90Circadian entrainment_Homo sapiens_hsa047130.33082472
91Pyruvate metabolism_Homo sapiens_hsa006200.32118477
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31478415
93Dopaminergic synapse_Homo sapiens_hsa047280.31054607
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28095657
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27977407
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27976017
97Mismatch repair_Homo sapiens_hsa034300.25560312
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25051181
99Systemic lupus erythematosus_Homo sapiens_hsa053220.24228187
100Serotonergic synapse_Homo sapiens_hsa047260.22595301

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