ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.76003028
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.79920324
3	replication fork processing (GO:0031297)	4.88979761
4	arginine catabolic process (GO:0006527)	4.30738288
5	response to pheromone (GO:0019236)	4.18859543
6	fibroblast migration (GO:0010761)	4.14697060
7	protein neddylation (GO:0045116)	4.05002032
8	signal peptide processing (GO:0006465)	4.01842171
9	proteasome assembly (GO:0043248)	3.98625624
10	cullin deneddylation (GO:0010388)	3.90114973
11	parturition (GO:0007567)	3.82043947
12	peptidyl-arginine omega-N-methylation (GO:0035247)	3.81988851
13	protein deneddylation (GO:0000338)	3.75908147
14	muscle cell fate commitment (GO:0042693)	3.68392164
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.66737445
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.66737445
17	inositol phosphate catabolic process (GO:0071545)	3.56100012
18	protein polyglutamylation (GO:0018095)	3.55441010
19	protein complex biogenesis (GO:0070271)	3.53452193
20	rRNA modification (GO:0000154)	3.50155099
21	seminiferous tubule development (GO:0072520)	3.49839417
22	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.46729835
23	peptidyl-arginine N-methylation (GO:0035246)	3.41839273
24	peptidyl-arginine methylation (GO:0018216)	3.41839273
25	GTP biosynthetic process (GO:0006183)	3.41246702
26	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.41043582
27	mannosylation (GO:0097502)	3.39827308
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.38749948
29	ubiquinone biosynthetic process (GO:0006744)	3.37734297
30	male meiosis I (GO:0007141)	3.37365894
31	single strand break repair (GO:0000012)	3.36049552
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.35466449
33	regulation of mitotic spindle checkpoint (GO:1903504)	3.35466449
34	maturation of 5.8S rRNA (GO:0000460)	3.35330267
35	inositol phosphate dephosphorylation (GO:0046855)	3.35066130
36	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.35066130
37	negative regulation by host of viral transcription (GO:0043922)	3.32362583
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.26946382
39	cellular response to ATP (GO:0071318)	3.17830310
40	sequestering of actin monomers (GO:0042989)	3.14633016
41	cytidine metabolic process (GO:0046087)	3.13873692
42	cytidine catabolic process (GO:0006216)	3.13873692
43	cytidine deamination (GO:0009972)	3.13873692
44	ubiquinone metabolic process (GO:0006743)	3.11868456
45	cornea development in camera-type eye (GO:0061303)	3.10781135
46	positive regulation of male gonad development (GO:2000020)	3.10432160
47	histone arginine methylation (GO:0034969)	3.10232971
48	peptidyl-histidine modification (GO:0018202)	3.08348922
49	meiosis I (GO:0007127)	3.07639981
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07446021
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05502927
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04822275
53	NADH dehydrogenase complex assembly (GO:0010257)	3.04822275
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04822275
55	positive regulation of defense response to virus by host (GO:0002230)	3.01973070
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99532802
57	polyol catabolic process (GO:0046174)	2.97588342
58	UTP biosynthetic process (GO:0006228)	2.94110310
59	regulation of male gonad development (GO:2000018)	2.86977508
60	ncRNA 3-end processing (GO:0043628)	2.86357364
61	aldehyde catabolic process (GO:0046185)	2.83207772
62	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.82923263
63	regulation of cardiac muscle cell contraction (GO:0086004)	2.82782629
64	DNA strand renaturation (GO:0000733)	2.82740818
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80745855
66	lipopolysaccharide metabolic process (GO:0008653)	2.79505127
67	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75188652
68	behavioral response to nicotine (GO:0035095)	2.74765357
69	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.73841642
70	regulation of cellular amino acid metabolic process (GO:0006521)	2.72932653
71	lipopolysaccharide biosynthetic process (GO:0009103)	2.72716834
72	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.70972509
73	olfactory bulb development (GO:0021772)	2.70944629
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70289437
75	UTP metabolic process (GO:0046051)	2.70260061
76	kinetochore assembly (GO:0051382)	2.70253990
77	quinone biosynthetic process (GO:1901663)	2.70008010
78	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.69943846
79	pseudouridine synthesis (GO:0001522)	2.68988103
80	protein prenylation (GO:0018342)	2.68282035
81	prenylation (GO:0097354)	2.68282035
82	DNA demethylation (GO:0080111)	2.67167579
83	negative regulation of macrophage differentiation (GO:0045650)	2.65953954
84	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.65470976
85	CTP biosynthetic process (GO:0006241)	2.63157120
86	CTP metabolic process (GO:0046036)	2.63157120
87	termination of RNA polymerase III transcription (GO:0006386)	2.62563239
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.62563239
89	kinetochore organization (GO:0051383)	2.61885051
90	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61872611
91	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.57128022
92	regulation of integrin-mediated signaling pathway (GO:2001044)	2.56892207
93	lymphangiogenesis (GO:0001946)	2.50056939
94	endoderm formation (GO:0001706)	2.48907678
95	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.48609254
96	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.47300496
97	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.47300496
98	protein peptidyl-prolyl isomerization (GO:0000413)	2.46640023
99	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.46635176
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.46635176

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.21041137
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26902131
3	VDR_22108803_ChIP-Seq_LS180_Human	2.89611989
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.79969718
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.78905215
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70531732
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.64110449
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.53147933
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.49406241
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49347417
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43836704
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.37458641
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27625717
14	FUS_26573619_Chip-Seq_HEK293_Human	2.22242170
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19486317
16	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.15546710
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12378018
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02495034
19	BCAT_22108803_ChIP-Seq_LS180_Human	2.01223697
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94388609
21	EWS_26573619_Chip-Seq_HEK293_Human	1.92234231
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.86679305
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85685539
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84994835
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84748925
26	P300_19829295_ChIP-Seq_ESCs_Human	1.78082853
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.75583489
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70965109
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.67660430
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67432050
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.67293690
32	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65109199
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60879181
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.60459130
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.59744574
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52491363
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50666431
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49283260
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47655477
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43385554
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.43385554
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43233162
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42454042
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42322186
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42322186
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41257448
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41237242
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41162084
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41029585
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38025423
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32575269
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30926575
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.27529069
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26624231
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.26539965
56	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22365195
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21946588
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18502922
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17826563
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17803019
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17754014
62	AR_20517297_ChIP-Seq_VCAP_Human	1.17372080
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.16740967
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15609027
65	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.14911702
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14874774
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14851504
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14702921
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.13683056
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13549739
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13356250
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12944528
73	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.11375139
74	STAT3_23295773_ChIP-Seq_U87_Human	1.11301093
75	NCOR_22424771_ChIP-Seq_293T_Human	1.08618188
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08383191
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08012231
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07701489
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06563408
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05558497
81	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05310723
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05268053
83	TCF4_23295773_ChIP-Seq_U87_Human	1.04778949
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04169617
85	AR_25329375_ChIP-Seq_VCAP_Human	1.03671872
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02946749
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01474312
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01394915
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01394915
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01049324
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00576718
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00415296
93	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.99662696
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98761824
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98026473
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97844181
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96030767
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95813860
99	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95189322
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94806367

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	3.55771331
2	MP0003950_abnormal_plasma_membrane	3.48374754
3	MP0006054_spinal_hemorrhage	3.24033187
4	MP0003880_abnormal_central_pattern	2.70327844
5	MP0003011_delayed_dark_adaptation	2.67716330
6	MP0006072_abnormal_retinal_apoptosis	2.50196162
7	MP0002736_abnormal_nociception_after	2.31090608
8	MP0000427_abnormal_hair_cycle	2.23742210
9	MP0005253_abnormal_eye_physiology	2.23035041
10	MP0008995_early_reproductive_senescence	2.15002365
11	MP0000372_irregular_coat_pigmentation	2.11252165
12	MP0001968_abnormal_touch/_nociception	1.99714144
13	MP0003806_abnormal_nucleotide_metabolis	1.89703008
14	MP0002102_abnormal_ear_morphology	1.86856799
15	MP0003195_calcinosis	1.86704181
16	MP0006292_abnormal_olfactory_placode	1.86215774
17	MP0002653_abnormal_ependyma_morphology	1.84270769
18	MP0010386_abnormal_urinary_bladder	1.81266624
19	MP0005551_abnormal_eye_electrophysiolog	1.76521344
20	MP0005360_urolithiasis	1.74926001
21	MP0003786_premature_aging	1.72132141
22	MP0008058_abnormal_DNA_repair	1.66446262
23	MP0008877_abnormal_DNA_methylation	1.64024581
24	MP0008775_abnormal_heart_ventricle	1.60255204
25	MP0000569_abnormal_digit_pigmentation	1.55810192
26	MP0008872_abnormal_physiological_respon	1.50192465
27	MP0001529_abnormal_vocalization	1.47439383
28	MP0005389_reproductive_system_phenotype	1.45813174
29	MP0003567_abnormal_fetal_cardiomyocyte	1.44969087
30	MP0001919_abnormal_reproductive_system	1.44619344
31	MP0001501_abnormal_sleep_pattern	1.43628714
32	MP0009697_abnormal_copulation	1.43084034
33	MP0001764_abnormal_homeostasis	1.42757357
34	MP0002938_white_spotting	1.34300194
35	MP0009384_cardiac_valve_regurgitation	1.31038529
36	MP0006276_abnormal_autonomic_nervous	1.27961893
37	MP0002160_abnormal_reproductive_system	1.27080291
38	MP0004142_abnormal_muscle_tone	1.26734848
39	MP0002837_dystrophic_cardiac_calcinosis	1.25256431
40	MP0004215_abnormal_myocardial_fiber	1.24878952
41	MP0000538_abnormal_urinary_bladder	1.24411209
42	MP0001986_abnormal_taste_sensitivity	1.22264967
43	MP0005646_abnormal_pituitary_gland	1.21542229
44	MP0005410_abnormal_fertilization	1.19091947
45	MP0001485_abnormal_pinna_reflex	1.18488240
46	MP0003186_abnormal_redox_activity	1.17676849
47	MP0005391_vision/eye_phenotype	1.17436395
48	MP0008875_abnormal_xenobiotic_pharmacok	1.17328748
49	MP0000516_abnormal_urinary_system	1.16940638
50	MP0005367_renal/urinary_system_phenotyp	1.16940638
51	MP0004084_abnormal_cardiac_muscle	1.16610357
52	MP0002638_abnormal_pupillary_reflex	1.13489984
53	MP0003718_maternal_effect	1.07233499
54	MP0010368_abnormal_lymphatic_system	1.06390714
55	MP0004484_altered_response_of	1.05966570
56	MP0002210_abnormal_sex_determination	1.03431856
57	MP0001879_abnormal_lymphatic_vessel	1.02947655
58	MP0005195_abnormal_posterior_eye	1.02100419
59	MP0001486_abnormal_startle_reflex	0.98675915
60	MP0001293_anophthalmia	0.96278816
61	MP0003787_abnormal_imprinting	0.96259785
62	MP0000013_abnormal_adipose_tissue	0.95209317
63	MP0004147_increased_porphyrin_level	0.94219579
64	MP0001119_abnormal_female_reproductive	0.91923663
65	MP0003937_abnormal_limbs/digits/tail_de	0.91684737
66	MP0005332_abnormal_amino_acid	0.91649763
67	MP0002272_abnormal_nervous_system	0.91030581
68	MP0000749_muscle_degeneration	0.88687765
69	MP0001286_abnormal_eye_development	0.88437340
70	MP0001905_abnormal_dopamine_level	0.88140888
71	MP0008789_abnormal_olfactory_epithelium	0.87038574
72	MP0002168_other_aberrant_phenotype	0.85712026
73	MP0009745_abnormal_behavioral_response	0.84926181
74	MP0000383_abnormal_hair_follicle	0.84611273
75	MP0000631_abnormal_neuroendocrine_gland	0.81168857
76	MP0005395_other_phenotype	0.80979124
77	MP0009333_abnormal_splenocyte_physiolog	0.80598600
78	MP0001853_heart_inflammation	0.80585735
79	MP0003137_abnormal_impulse_conducting	0.78329320
80	MP0005171_absent_coat_pigmentation	0.78326595
81	MP0003698_abnormal_male_reproductive	0.78050475
82	MP0001929_abnormal_gametogenesis	0.77434779
83	MP0003693_abnormal_embryo_hatching	0.77139978
84	MP0003122_maternal_imprinting	0.76806135
85	MP0001299_abnormal_eye_distance/	0.76478912
86	MP0001145_abnormal_male_reproductive	0.75679580
87	MP0003121_genomic_imprinting	0.75606904
88	MP0002177_abnormal_outer_ear	0.75515464
89	MP0002752_abnormal_somatic_nervous	0.74690424
90	MP0002751_abnormal_autonomic_nervous	0.74308807
91	MP0000653_abnormal_sex_gland	0.73086358
92	MP0000049_abnormal_middle_ear	0.72857591
93	MP0003283_abnormal_digestive_organ	0.72459183
94	MP0003890_abnormal_embryonic-extraembry	0.72074566
95	MP0002095_abnormal_skin_pigmentation	0.71314350
96	MP0005595_abnormal_vascular_smooth	0.70534110
97	MP0002282_abnormal_trachea_morphology	0.70457227
98	MP0000778_abnormal_nervous_system	0.69724666
99	MP0004885_abnormal_endolymph	0.68866290
100	MP0006035_abnormal_mitochondrial_morpho	0.68370112

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.35912668
2	Type 2 muscle fiber atrophy (HP:0003554)	4.16848999
3	Molar tooth sign on MRI (HP:0002419)	3.95225832
4	Abnormality of midbrain morphology (HP:0002418)	3.95225832
5	Pancreatic fibrosis (HP:0100732)	3.86384601
6	Chronic hepatic failure (HP:0100626)	3.82627036
7	Muscle fiber atrophy (HP:0100295)	3.52771998
8	Nephronophthisis (HP:0000090)	3.46385847
9	Pancreatic cysts (HP:0001737)	3.13968232
10	Acute necrotizing encephalopathy (HP:0006965)	3.01476195
11	Abnormality of the renal medulla (HP:0100957)	2.87174187
12	Type I transferrin isoform profile (HP:0003642)	2.77126601
13	Amniotic constriction ring (HP:0009775)	2.76830613
14	Abnormality of placental membranes (HP:0011409)	2.76830613
15	Renal cortical cysts (HP:0000803)	2.73051918
16	Acute encephalopathy (HP:0006846)	2.72798287
17	Medial flaring of the eyebrow (HP:0010747)	2.64322984
18	Abnormality of DNA repair (HP:0003254)	2.57920587
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.57233258
20	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.56819546
21	Abnormality of the renal cortex (HP:0011035)	2.56572837
22	Abnormal protein glycosylation (HP:0012346)	2.51761423
23	Abnormal glycosylation (HP:0012345)	2.51761423
24	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.51761423
25	Abnormal protein N-linked glycosylation (HP:0012347)	2.51761423
26	Fatigable weakness (HP:0003473)	2.50166680
27	Abnormality of the neuromuscular junction (HP:0003398)	2.50166680
28	Mitochondrial inheritance (HP:0001427)	2.42569332
29	Progressive macrocephaly (HP:0004481)	2.40695420
30	Popliteal pterygium (HP:0009756)	2.38605429
31	Thyroiditis (HP:0100646)	2.36417073
32	Methylmalonic acidemia (HP:0002912)	2.36375043
33	Severe combined immunodeficiency (HP:0004430)	2.34675595
34	Weak cry (HP:0001612)	2.32196649
35	Stenosis of the external auditory canal (HP:0000402)	2.32110297
36	Gonadal dysgenesis (HP:0000133)	2.29650728
37	Male pseudohermaphroditism (HP:0000037)	2.28491494
38	Congenital stationary night blindness (HP:0007642)	2.25812149
39	Increased CSF lactate (HP:0002490)	2.24260954
40	Methylmalonic aciduria (HP:0012120)	2.21040779
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20575134
42	Panhypogammaglobulinemia (HP:0003139)	2.19611631
43	Disproportionate short-trunk short stature (HP:0003521)	2.16742391
44	Submucous cleft hard palate (HP:0000176)	2.16141355
45	Anencephaly (HP:0002323)	2.14892330
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14837504
47	Abnormality of macular pigmentation (HP:0008002)	2.14191345
48	Intestinal atresia (HP:0011100)	2.12690582
49	Absent speech (HP:0001344)	2.10033699
50	Chronic mucocutaneous candidiasis (HP:0002728)	2.09758120
51	Recurrent cutaneous fungal infections (HP:0011370)	2.09758120
52	Narrow forehead (HP:0000341)	2.07197974
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04600785
54	Abnormality of alanine metabolism (HP:0010916)	2.04600785
55	Hyperalaninemia (HP:0003348)	2.04600785
56	Abnormality of T cell physiology (HP:0011840)	2.03358434
57	Chorioretinal atrophy (HP:0000533)	1.99865296
58	Cerebral edema (HP:0002181)	1.99427528
59	Occipital encephalocele (HP:0002085)	1.98956549
60	Pendular nystagmus (HP:0012043)	1.98933681
61	Entropion (HP:0000621)	1.98576330
62	Central scotoma (HP:0000603)	1.97853677
63	Asplenia (HP:0001746)	1.97344501
64	Congenital primary aphakia (HP:0007707)	1.96921630
65	Gait imbalance (HP:0002141)	1.94909041
66	Nephrogenic diabetes insipidus (HP:0009806)	1.93180526
67	Thyroid-stimulating hormone excess (HP:0002925)	1.92029433
68	Abnormality of T cells (HP:0002843)	1.91503566
69	Hepatic necrosis (HP:0002605)	1.91420794
70	Congenital hepatic fibrosis (HP:0002612)	1.90125689
71	IgG deficiency (HP:0004315)	1.90041690
72	Decreased muscle mass (HP:0003199)	1.89552902
73	Postaxial foot polydactyly (HP:0001830)	1.87909358
74	Abnormal hair whorl (HP:0010721)	1.85639922
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85008637
76	Cystic liver disease (HP:0006706)	1.84759756
77	Hepatocellular necrosis (HP:0001404)	1.84448897
78	Abnormal lung lobation (HP:0002101)	1.82854677
79	Sclerocornea (HP:0000647)	1.82781563
80	Optic disc pallor (HP:0000543)	1.79027213
81	Abnormality of the labia minora (HP:0012880)	1.77782421
82	Astigmatism (HP:0000483)	1.75916849
83	Small hand (HP:0200055)	1.75520463
84	Dyschromatopsia (HP:0007641)	1.73444980
85	Keratoconus (HP:0000563)	1.73190188
86	Increased corneal curvature (HP:0100692)	1.73190188
87	Dandy-Walker malformation (HP:0001305)	1.72595550
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.71167712
89	Abolished electroretinogram (ERG) (HP:0000550)	1.70177131
90	Reticulocytopenia (HP:0001896)	1.69818995
91	Upper motor neuron abnormality (HP:0002127)	1.66638807
92	Increased serum lactate (HP:0002151)	1.65870741
93	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.65153197
94	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.65153197
95	Hypoplastic heart (HP:0001961)	1.64701806
96	Postaxial hand polydactyly (HP:0001162)	1.64365193
97	Nausea (HP:0002018)	1.63570797
98	Short foot (HP:0001773)	1.63127022
99	Long clavicles (HP:0000890)	1.62907388
100	Abnormality of small intestinal villus morphology (HP:0011472)	1.61098310

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	3.90649929
2	EIF2AK3	3.34740503
3	NUAK1	2.91366491
4	MAPK13	2.62142002
5	PRKD3	2.56277048
6	STK39	2.52413325
7	MAP4K2	2.32851319
8	WNK3	2.22389896
9	KDR	2.14843668
10	ADRBK2	2.07586728
11	TAOK3	2.03346676
12	FRK	1.95819214
13	MUSK	1.80396048
14	BUB1	1.69985590
15	CASK	1.69885384
16	LIMK1	1.68046965
17	OXSR1	1.66058973
18	DYRK2	1.53378209
19	NEK1	1.52299148
20	BCR	1.48663517
21	MKNK2	1.42896133
22	CDK8	1.42167200
23	PLK2	1.41935013
24	TRIM28	1.31549371
25	MAP3K4	1.30817992
26	BCKDK	1.30424565
27	PAK3	1.27792841
28	WNK4	1.26100448
29	PRKD2	1.26078144
30	TXK	1.23084308
31	CSNK1G1	1.21253022
32	FES	1.17486511
33	EIF2AK1	1.14238934
34	VRK2	1.08775106
35	MAP2K7	1.08731226
36	GRK1	1.06707832
37	ZAK	1.04247844
38	MYLK	1.03341232
39	INSRR	1.00922940
40	BMPR1B	0.99801217
41	TIE1	0.99291124
42	VRK1	0.97021531
43	TAF1	0.96889498
44	EPHA4	0.93480464
45	TEC	0.92108472
46	MAP2K6	0.91772647
47	ILK	0.91259699
48	CSNK1G2	0.90411726
49	PLK4	0.88772991
50	TLK1	0.86575465
51	GRK7	0.85061596
52	CAMKK2	0.82582619
53	AKT3	0.82134236
54	WEE1	0.81711589
55	PINK1	0.81582780
56	PRKCE	0.80659585
57	MAP3K12	0.79121414
58	CSNK1G3	0.78990579
59	RPS6KA4	0.78439881
60	PTK2B	0.78339600
61	MKNK1	0.78288140
62	PRKCQ	0.75904069
63	DYRK1A	0.74958673
64	CAMK1	0.74358010
65	PKN1	0.69169435
66	PLK3	0.68773410
67	PIK3CA	0.68130147
68	PRKCH	0.63236442
69	PRKCG	0.55699239
70	TNK2	0.55301988
71	FGFR1	0.52624653
72	PBK	0.52338636
73	CAMK4	0.52000461
74	PIK3CG	0.50778483
75	ITK	0.50411397
76	STK16	0.49962605
77	OBSCN	0.49430596
78	CSNK1A1L	0.49057897
79	RAF1	0.48244442
80	MARK1	0.47899772
81	ERBB3	0.47726900
82	IGF1R	0.45963623
83	ATR	0.45417948
84	AURKB	0.44821291
85	TSSK6	0.44460691
86	PRKD1	0.44272088
87	TESK1	0.43794083
88	ROCK1	0.43691669
89	MINK1	0.41795742
90	PRKACA	0.40212016
91	RPS6KA5	0.39009852
92	ATM	0.36220803
93	TGFBR2	0.35907660
94	CAMK2A	0.35311838
95	PRKCA	0.34288327
96	PLK1	0.33544185
97	ERBB4	0.31768753
98	ABL1	0.31629380
99	STK3	0.31461622
100	PRKCD	0.31103150

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	5.44731321
2	Proteasome_Homo sapiens_hsa03050	4.20405005
3	RNA polymerase_Homo sapiens_hsa03020	3.11999525
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.63368511
5	Parkinsons disease_Homo sapiens_hsa05012	2.62056789
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.30079870
7	Ribosome_Homo sapiens_hsa03010	2.16570070
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.08038236
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.97075311
10	Fatty acid elongation_Homo sapiens_hsa00062	1.95016951
11	Non-homologous end-joining_Homo sapiens_hsa03450	1.89978659
12	Basal transcription factors_Homo sapiens_hsa03022	1.87227429
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.85023512
14	One carbon pool by folate_Homo sapiens_hsa00670	1.76939528
15	Propanoate metabolism_Homo sapiens_hsa00640	1.73372614
16	Alzheimers disease_Homo sapiens_hsa05010	1.71706829
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.61948558
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.59211182
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56732902
20	Huntingtons disease_Homo sapiens_hsa05016	1.54942368
21	RNA degradation_Homo sapiens_hsa03018	1.54798548
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54546887
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53739652
24	Butanoate metabolism_Homo sapiens_hsa00650	1.53312774
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48303601
26	Regulation of autophagy_Homo sapiens_hsa04140	1.46371304
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44782559
28	Phototransduction_Homo sapiens_hsa04744	1.42484286
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.36532670
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32844018
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32099835
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.27221881
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18909715
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18546583
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.18172701
36	Homologous recombination_Homo sapiens_hsa03440	1.16573870
37	RNA transport_Homo sapiens_hsa03013	1.12055252
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09432446
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07413492
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05267981
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00563823
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99928628
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99157435
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97449227
45	Peroxisome_Homo sapiens_hsa04146	0.95973129
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91941995
47	Purine metabolism_Homo sapiens_hsa00230	0.91847169
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91706846
49	Olfactory transduction_Homo sapiens_hsa04740	0.86762289
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84593215
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82800642
52	Spliceosome_Homo sapiens_hsa03040	0.81782206
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80107767
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.78090966
55	Metabolic pathways_Homo sapiens_hsa01100	0.75620218
56	Fatty acid degradation_Homo sapiens_hsa00071	0.73934741
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71000784
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.70865670
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70815318
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70010730
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.67215964
62	Salivary secretion_Homo sapiens_hsa04970	0.66863593
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.64675593
64	Retinol metabolism_Homo sapiens_hsa00830	0.62969711
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60114716
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59304889
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58739397
68	Caffeine metabolism_Homo sapiens_hsa00232	0.55724477
69	Mineral absorption_Homo sapiens_hsa04978	0.53156884
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51745557
71	Circadian rhythm_Homo sapiens_hsa04710	0.48845579
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47952328
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47107806
74	Glutathione metabolism_Homo sapiens_hsa00480	0.43740462
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43474893
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43332765
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41518094
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41181214
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39092421
80	Sulfur relay system_Homo sapiens_hsa04122	0.38439842
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37263254
82	Morphine addiction_Homo sapiens_hsa05032	0.36518252
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31689407
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.30661781
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.30125895
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29944003
87	Renin-angiotensin system_Homo sapiens_hsa04614	0.27598678
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26983011
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26199111
90	Salmonella infection_Homo sapiens_hsa05132	0.25387685
91	Serotonergic synapse_Homo sapiens_hsa04726	0.25050846
92	Circadian entrainment_Homo sapiens_hsa04713	0.24434723
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.23547292
94	Oocyte meiosis_Homo sapiens_hsa04114	0.23106295
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.22617535
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.22390463
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.21529742
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.21518035
99	Pancreatic secretion_Homo sapiens_hsa04972	0.19522082
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.19340307

RPLP1P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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