RPLP1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.61766492
2viral transcription (GO:0019083)6.57729966
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36734566
4translational termination (GO:0006415)6.35197525
5ATP synthesis coupled proton transport (GO:0015986)6.28392912
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.28392912
7ribosomal small subunit assembly (GO:0000028)6.26122164
8ribosomal small subunit biogenesis (GO:0042274)5.79882466
9protein neddylation (GO:0045116)5.72737119
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.44213955
11translational elongation (GO:0006414)5.38666739
12maturation of SSU-rRNA (GO:0030490)5.37561762
13cotranslational protein targeting to membrane (GO:0006613)5.34755747
14protein targeting to ER (GO:0045047)5.34137069
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.07922020
16protein localization to endoplasmic reticulum (GO:0070972)5.05354897
17cellular protein complex disassembly (GO:0043624)4.75646772
18viral life cycle (GO:0019058)4.71070366
19DNA deamination (GO:0045006)4.62468314
20protein complex biogenesis (GO:0070271)4.62212186
21piRNA metabolic process (GO:0034587)4.61607616
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.57111746
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.54611178
24translational initiation (GO:0006413)4.40180403
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39154042
26respiratory electron transport chain (GO:0022904)4.36223643
27electron transport chain (GO:0022900)4.34618150
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.33986122
29mitochondrial respiratory chain complex assembly (GO:0033108)4.27831532
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23191836
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.23191836
32NADH dehydrogenase complex assembly (GO:0010257)4.23191836
33proteasome assembly (GO:0043248)4.17832524
34translation (GO:0006412)4.09878037
35respiratory chain complex IV assembly (GO:0008535)4.02222702
36cytochrome complex assembly (GO:0017004)3.90823657
37protein complex disassembly (GO:0043241)3.90401865
38pyrimidine nucleotide catabolic process (GO:0006244)3.86678436
39ribosomal large subunit biogenesis (GO:0042273)3.80021055
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.76341372
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.76341372
42ATP biosynthetic process (GO:0006754)3.72960939
43DNA methylation involved in gamete generation (GO:0043046)3.71992848
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.71721359
45macromolecular complex disassembly (GO:0032984)3.70267973
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.68524086
47GTP biosynthetic process (GO:0006183)3.67796023
48cellular component biogenesis (GO:0044085)3.67076232
49male meiosis I (GO:0007141)3.64211408
50base-excision repair, AP site formation (GO:0006285)3.59463256
51water-soluble vitamin biosynthetic process (GO:0042364)3.53330858
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52835993
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50545977
54synapsis (GO:0007129)3.50174128
55protein targeting to membrane (GO:0006612)3.49463825
56ribonucleoprotein complex biogenesis (GO:0022613)3.49330968
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.41199124
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37988125
59hydrogen ion transmembrane transport (GO:1902600)3.29428736
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.28419979
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23366097
62mRNA catabolic process (GO:0006402)3.22432603
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.20003315
64termination of RNA polymerase III transcription (GO:0006386)3.20003315
65UTP biosynthetic process (GO:0006228)3.15292052
66rRNA processing (GO:0006364)3.12844567
67meiosis I (GO:0007127)3.10631388
68rRNA metabolic process (GO:0016072)3.09728305
69ubiquinone biosynthetic process (GO:0006744)3.09371206
70regulation of mitochondrial translation (GO:0070129)3.07913099
71protein targeting to mitochondrion (GO:0006626)3.07625039
72deoxyribonucleotide catabolic process (GO:0009264)3.06098061
73negative regulation of telomerase activity (GO:0051974)3.05342497
74rRNA modification (GO:0000154)3.00030946
75proton transport (GO:0015992)2.99507705
76establishment of protein localization to mitochondrion (GO:0072655)2.96179934
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95364832
78negative regulation of ligase activity (GO:0051352)2.95364832
79UTP metabolic process (GO:0046051)2.95235280
80metallo-sulfur cluster assembly (GO:0031163)2.94556896
81iron-sulfur cluster assembly (GO:0016226)2.94556896
82hydrogen transport (GO:0006818)2.93071844
83RNA catabolic process (GO:0006401)2.90256976
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90242656
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88401044
86deoxyribose phosphate catabolic process (GO:0046386)2.86126759
87nucleoside triphosphate biosynthetic process (GO:0009142)2.85870056
88pseudouridine synthesis (GO:0001522)2.83987747
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82542279
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81841835
91tRNA processing (GO:0008033)2.81515665
92regulation of cellular amino acid metabolic process (GO:0006521)2.80517498
93maturation of 5.8S rRNA (GO:0000460)2.80365368
94protein localization to mitochondrion (GO:0070585)2.79649187
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79269536
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77969004
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77969004
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77969004
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76062890
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76062890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.64840220
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44400309
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38390489
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.92083331
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86276424
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.31161388
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29575042
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.15125967
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14592375
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80003648
11VDR_23849224_ChIP-Seq_CD4+_Human2.72195144
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63307569
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47405011
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38630598
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31853259
16FOXP3_21729870_ChIP-Seq_TREG_Human2.30246917
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28915306
18EZH2_22144423_ChIP-Seq_EOC_Human2.26626913
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24797411
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.12212226
21ELK1_19687146_ChIP-ChIP_HELA_Human2.08879584
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05081621
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.03187410
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87848983
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.87204259
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86086564
27TTF2_22483619_ChIP-Seq_HELA_Human1.85940462
28GABP_19822575_ChIP-Seq_HepG2_Human1.85702678
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84201617
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.82568989
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76018322
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75760353
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72977958
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72409869
35MYC_18940864_ChIP-ChIP_HL60_Human1.71285094
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67394143
37XRN2_22483619_ChIP-Seq_HELA_Human1.64817414
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56931183
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56653923
40ZNF274_21170338_ChIP-Seq_K562_Hela1.56114083
41DCP1A_22483619_ChIP-Seq_HELA_Human1.54944537
42VDR_22108803_ChIP-Seq_LS180_Human1.52694704
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49232024
44TP53_22573176_ChIP-Seq_HFKS_Human1.45261059
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39463796
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39027945
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.31830953
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30049985
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26912540
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22780207
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.21685342
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21273873
53ZNF263_19887448_ChIP-Seq_K562_Human1.20530854
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18331341
55TAF2_19829295_ChIP-Seq_ESCs_Human1.17258428
56NCOR_22424771_ChIP-Seq_293T_Human1.15978917
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15138928
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14757775
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13791242
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13758712
61IRF1_19129219_ChIP-ChIP_H3396_Human1.11437791
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11414201
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10408551
64NANOG_20526341_ChIP-Seq_ESCs_Human1.09198103
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.08082294
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08082294
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07012840
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06470888
69BCL6_27268052_Chip-Seq_Bcells_Human1.05780983
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.04050500
71KDM5A_27292631_Chip-Seq_BREAST_Human1.02591584
72ERA_21632823_ChIP-Seq_H3396_Human1.02012414
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00724293
74AR_20517297_ChIP-Seq_VCAP_Human1.00174104
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99801255
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97404884
77SA1_27219007_Chip-Seq_Bcells_Human0.96461374
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95757239
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95462492
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94741905
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.94716448
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.94591953
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93699366
84P53_21459846_ChIP-Seq_SAOS-2_Human0.93349181
85CTCF_26484167_Chip-Seq_Bcells_Mouse0.93126934
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92920775
87CTCF_20526341_ChIP-Seq_ESCs_Human0.92717894
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89907654
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88927695
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.88853681
91MYC_19829295_ChIP-Seq_ESCs_Human0.88495145
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87989464
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87969565
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87260619
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.85018200
96EWS_26573619_Chip-Seq_HEK293_Human0.84851411
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.84808788
98P300_27268052_Chip-Seq_Bcells_Human0.84118179
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82658366
100OCT4_20526341_ChIP-Seq_ESCs_Human0.82606424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.05737493
2MP0006292_abnormal_olfactory_placode4.03485335
3MP0008877_abnormal_DNA_methylation2.88342209
4MP0008789_abnormal_olfactory_epithelium2.77435573
5MP0002653_abnormal_ependyma_morphology2.54131638
6MP0008058_abnormal_DNA_repair2.33038219
7MP0003806_abnormal_nucleotide_metabolis2.27163481
8MP0005394_taste/olfaction_phenotype2.17104757
9MP0005499_abnormal_olfactory_system2.17104757
10MP0002163_abnormal_gland_morphology2.12705589
11MP0002736_abnormal_nociception_after2.01202288
12MP0002102_abnormal_ear_morphology2.00329328
13MP0002876_abnormal_thyroid_physiology2.00141204
14MP0008875_abnormal_xenobiotic_pharmacok1.97923179
15MP0002277_abnormal_respiratory_mucosa1.95343670
16MP0002837_dystrophic_cardiac_calcinosis1.93062118
17MP0001968_abnormal_touch/_nociception1.86673580
18MP0003011_delayed_dark_adaptation1.82901825
19MP0005671_abnormal_response_to1.82150232
20MP0003646_muscle_fatigue1.81154189
21MP0004145_abnormal_muscle_electrophysio1.80093346
22MP0002138_abnormal_hepatobiliary_system1.77156943
23MP0005551_abnormal_eye_electrophysiolog1.76476157
24MP0004142_abnormal_muscle_tone1.68866340
25MP0010030_abnormal_orbit_morphology1.67532805
26MP0008872_abnormal_physiological_respon1.66123263
27MP0005360_urolithiasis1.58668203
28MP0003718_maternal_effect1.57785185
29MP0001293_anophthalmia1.53941983
30MP0000049_abnormal_middle_ear1.53330614
31MP0002234_abnormal_pharynx_morphology1.51260596
32MP0006036_abnormal_mitochondrial_physio1.50779495
33MP0005646_abnormal_pituitary_gland1.50754159
34MP0003693_abnormal_embryo_hatching1.47969170
35MP0005389_reproductive_system_phenotype1.45661687
36MP0002160_abnormal_reproductive_system1.44744584
37MP0005075_abnormal_melanosome_morpholog1.42041559
38MP0001529_abnormal_vocalization1.41468468
39MP0003186_abnormal_redox_activity1.40985758
40MP0006072_abnormal_retinal_apoptosis1.40252364
41MP0002210_abnormal_sex_determination1.40198841
42MP0000685_abnormal_immune_system1.39733867
43MP0001835_abnormal_antigen_presentation1.38881571
44MP0002095_abnormal_skin_pigmentation1.35682629
45MP0003878_abnormal_ear_physiology1.33732043
46MP0005377_hearing/vestibular/ear_phenot1.33732043
47MP0004885_abnormal_endolymph1.31100018
48MP0001984_abnormal_olfaction1.28643006
49MP0005379_endocrine/exocrine_gland_phen1.28590751
50MP0005084_abnormal_gallbladder_morpholo1.23891761
51MP0001485_abnormal_pinna_reflex1.21858744
52MP0006276_abnormal_autonomic_nervous1.19525212
53MP0000372_irregular_coat_pigmentation1.15457691
54MP0001929_abnormal_gametogenesis1.15086246
55MP0001919_abnormal_reproductive_system1.14186265
56MP0003786_premature_aging1.08644046
57MP0001440_abnormal_grooming_behavior1.06401593
58MP0005174_abnormal_tail_pigmentation1.04568498
59MP0009333_abnormal_splenocyte_physiolog1.04328511
60MP0001145_abnormal_male_reproductive1.04227754
61MP0004742_abnormal_vestibular_system1.00658540
62MP0000653_abnormal_sex_gland0.99266159
63MP0001986_abnormal_taste_sensitivity0.98721006
64MP0001905_abnormal_dopamine_level0.97247744
65MP0005332_abnormal_amino_acid0.96529934
66MP0002938_white_spotting0.95834348
67MP0004043_abnormal_pH_regulation0.92767699
68MP0001800_abnormal_humoral_immune0.92551925
69MP0008007_abnormal_cellular_replicative0.91427904
70MP0000631_abnormal_neuroendocrine_gland0.91046784
71MP0004782_abnormal_surfactant_physiolog0.90839082
72MP0001873_stomach_inflammation0.90641627
73MP0001881_abnormal_mammary_gland0.90137130
74MP0010094_abnormal_chromosome_stability0.89617781
75MP0005645_abnormal_hypothalamus_physiol0.89449291
76MP0000015_abnormal_ear_pigmentation0.89090228
77MP0003698_abnormal_male_reproductive0.86484649
78MP0001348_abnormal_lacrimal_gland0.86375904
79MP0003195_calcinosis0.83972176
80MP0001119_abnormal_female_reproductive0.82730692
81MP0003938_abnormal_ear_development0.82580225
82MP0005195_abnormal_posterior_eye0.82274518
83MP0005387_immune_system_phenotype0.80163495
84MP0001790_abnormal_immune_system0.80163495
85MP0004019_abnormal_vitamin_homeostasis0.77822128
86MP0001346_abnormal_lacrimal_gland0.76829169
87MP0002249_abnormal_larynx_morphology0.76648590
88MP0002148_abnormal_hypersensitivity_rea0.76533058
89MP0004957_abnormal_blastocyst_morpholog0.76475233
90MP0002723_abnormal_immune_serum0.76109023
91MP0003567_abnormal_fetal_cardiomyocyte0.75564993
92MP0004147_increased_porphyrin_level0.75006361
93MP0009745_abnormal_behavioral_response0.74904947
94MP0002272_abnormal_nervous_system0.74648192
95MP0000427_abnormal_hair_cycle0.74456204
96MP0003136_yellow_coat_color0.72754351
97MP0005253_abnormal_eye_physiology0.71135003
98MP0002233_abnormal_nose_morphology0.69982983
99MP0002733_abnormal_thermal_nociception0.69888547
100MP0005636_abnormal_mineral_homeostasis0.69406182

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.76819269
2Reticulocytopenia (HP:0001896)4.52950624
3Mitochondrial inheritance (HP:0001427)4.47249924
4Abnormal mitochondria in muscle tissue (HP:0008316)4.39346405
5Acute encephalopathy (HP:0006846)4.15120518
6Abnormality of cells of the erythroid lineage (HP:0012130)4.07433428
7Increased CSF lactate (HP:0002490)4.06651448
8Increased hepatocellular lipid droplets (HP:0006565)3.95828686
9Progressive macrocephaly (HP:0004481)3.89506215
10Lipid accumulation in hepatocytes (HP:0006561)3.75284735
11Macrocytic anemia (HP:0001972)3.72310212
12Abnormal number of erythroid precursors (HP:0012131)3.65355585
13Renal Fanconi syndrome (HP:0001994)3.59791919
14Increased intramyocellular lipid droplets (HP:0012240)3.46692974
15Hepatocellular necrosis (HP:0001404)3.44084288
163-Methylglutaconic aciduria (HP:0003535)3.24509126
17Hepatic necrosis (HP:0002605)3.20632911
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20184913
19Pallor (HP:0000980)3.04625565
20Septo-optic dysplasia (HP:0100842)2.94247872
21Increased muscle lipid content (HP:0009058)2.93021533
22Increased serum lactate (HP:0002151)2.92418725
23Molar tooth sign on MRI (HP:0002419)2.91850201
24Abnormality of midbrain morphology (HP:0002418)2.91850201
25Pancreatic fibrosis (HP:0100732)2.90648088
26Pancreatic cysts (HP:0001737)2.89568189
27Type II lissencephaly (HP:0007260)2.87022784
28Abnormal rod and cone electroretinograms (HP:0008323)2.85925662
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83677450
30Cerebral edema (HP:0002181)2.83312574
31Sclerocornea (HP:0000647)2.76012954
32Congenital stationary night blindness (HP:0007642)2.73634864
33Pendular nystagmus (HP:0012043)2.68657099
34Lactic acidosis (HP:0003128)2.67786272
35Nephronophthisis (HP:0000090)2.67654490
36Congenital, generalized hypertrichosis (HP:0004540)2.64812080
37Exertional dyspnea (HP:0002875)2.62353930
38Absent thumb (HP:0009777)2.62126222
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52801961
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52801961
41Methylmalonic aciduria (HP:0012120)2.46234704
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45290726
43Optic disc pallor (HP:0000543)2.45067868
44True hermaphroditism (HP:0010459)2.43703338
45Methylmalonic acidemia (HP:0002912)2.35046273
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.34248542
47Exercise intolerance (HP:0003546)2.34142200
48Absent/shortened dynein arms (HP:0200106)2.33162838
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.33162838
50Respiratory difficulties (HP:0002880)2.31947244
51Asplenia (HP:0001746)2.29424643
52Respiratory failure (HP:0002878)2.27079174
53Increased IgM level (HP:0003496)2.21223870
54Glycosuria (HP:0003076)2.21050155
55Abnormality of urine glucose concentration (HP:0011016)2.21050155
56Abolished electroretinogram (ERG) (HP:0000550)2.20988057
57IgG deficiency (HP:0004315)2.20410276
58Colon cancer (HP:0003003)2.15866020
59Rib fusion (HP:0000902)2.15781273
60Abnormality of alanine metabolism (HP:0010916)2.15418173
61Hyperalaninemia (HP:0003348)2.15418173
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15418173
63Lethargy (HP:0001254)2.11980017
64Abnormality of renal resorption (HP:0011038)2.11099702
65Abnormality of the renal medulla (HP:0100957)2.10473177
66Absent septum pellucidum (HP:0001331)2.09301560
67Abnormality of DNA repair (HP:0003254)2.08559326
68Pancytopenia (HP:0001876)2.06294365
69Medial flaring of the eyebrow (HP:0010747)2.04403932
70Abnormality of the renal cortex (HP:0011035)2.04294846
71Stomatitis (HP:0010280)2.02481371
72Abnormal ciliary motility (HP:0012262)2.00765124
73Leukodystrophy (HP:0002415)2.00590475
74Abnormal respiratory motile cilium physiology (HP:0012261)1.97088485
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92676860
76Polydipsia (HP:0001959)1.91485705
77Abnormal drinking behavior (HP:0030082)1.91485705
78Constricted visual fields (HP:0001133)1.89776567
79Abnormal respiratory epithelium morphology (HP:0012253)1.88738468
80Abnormal respiratory motile cilium morphology (HP:0005938)1.88738468
81Neutropenia (HP:0001875)1.85916443
82Type 2 muscle fiber atrophy (HP:0003554)1.85615743
83Abnormality of T cell physiology (HP:0011840)1.85386418
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82659090
85Elevated erythrocyte sedimentation rate (HP:0003565)1.78636531
86Severe visual impairment (HP:0001141)1.78299345
87Maternal diabetes (HP:0009800)1.77847828
88Abnormality of the ileum (HP:0001549)1.77810380
89Stenosis of the external auditory canal (HP:0000402)1.77056722
90Aplastic anemia (HP:0001915)1.76708538
91Hyperphosphaturia (HP:0003109)1.76691820
92Retinal dysplasia (HP:0007973)1.75833106
93Meckel diverticulum (HP:0002245)1.75690253
94Hyperglycinemia (HP:0002154)1.74750138
95Abnormality of the prostate (HP:0008775)1.74447910
96Aplasia/hypoplasia of the uterus (HP:0008684)1.72982612
97Renal cortical cysts (HP:0000803)1.71827533
98Abnormality of magnesium homeostasis (HP:0004921)1.71145324
99Cystic liver disease (HP:0006706)1.70128852
100Muscle fiber atrophy (HP:0100295)1.67640805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.81508178
2VRK23.71533261
3TLK12.95878669
4TXK2.65333023
5MUSK2.57460983
6BCKDK2.50913332
7ADRBK22.34340909
8BUB12.28842175
9NME12.28515152
10WNK42.28301534
11PBK2.08961585
12NME22.08848579
13ZAK1.94904181
14PDK21.94549734
15NUAK11.83477778
16EIF2AK31.81551958
17NEK11.79340045
18GRK11.73224167
19KDR1.69897085
20VRK11.68045585
21CDC71.65806938
22DYRK21.50939819
23TIE11.41456810
24TAF11.32666634
25IKBKB1.29344434
26MAP4K21.27441642
27EIF2AK11.25295384
28MAP2K21.21154459
29PLK41.20107973
30MAP3K121.18988994
31BMPR1B1.17358647
32FRK1.08634986
33CDK81.08538118
34CDK191.02746418
35ATR1.00509890
36MAP4K10.99791583
37ITK0.98641487
38TEC0.95938292
39OXSR10.93811690
40ABL20.93797980
41BTK0.93434270
42PLK10.92995251
43DAPK10.92493164
44PINK10.87660815
45DAPK30.85022918
46PLK30.83191963
47AURKA0.78723497
48CHEK20.78578848
49PIK3CA0.78434221
50FES0.76715436
51AURKB0.76406687
52MST40.75984695
53GRK60.75199492
54STK40.74648286
55TTK0.73487768
56RPS6KA50.73303403
57PLK20.73269168
58CSNK2A20.72389344
59EIF2AK20.72134234
60TAOK30.69094108
61PRKCQ0.68187314
62DAPK20.67320358
63PAK30.65866985
64CAMK10.65577148
65MYLK0.64628084
66CSNK2A10.64541753
67MAP3K110.62784217
68IKBKE0.62567661
69STK390.61830938
70ADRBK10.61163859
71LRRK20.60646658
72PRKCG0.60541051
73GRK50.59837844
74PRKCI0.59708202
75PIM10.58136218
76GRK70.57344518
77MARK30.56156095
78WNK30.50582452
79SYK0.50392129
80RPS6KA60.48364345
81SRPK10.48266136
82INSRR0.46994360
83CSNK1A10.46892504
84LIMK10.45622119
85MAPKAPK30.45265358
86OBSCN0.45261680
87CSNK1G30.44288202
88CSNK1G20.43524361
89PRKACA0.43091891
90LCK0.42773421
91NEK20.42593548
92PHKG10.41497715
93PHKG20.41497715
94PTK2B0.40774301
95CSF1R0.40118439
96PRKCA0.37869190
97ATM0.37641278
98LYN0.37325545
99KIT0.37004966
100STK110.35431504

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.69602504
2Oxidative phosphorylation_Homo sapiens_hsa001904.02752755
3Proteasome_Homo sapiens_hsa030503.72996921
4Parkinsons disease_Homo sapiens_hsa050123.26975516
5RNA polymerase_Homo sapiens_hsa030202.38700126
6Huntingtons disease_Homo sapiens_hsa050162.38689483
7Homologous recombination_Homo sapiens_hsa034402.28520900
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22815970
9Alzheimers disease_Homo sapiens_hsa050102.20503557
10Sulfur relay system_Homo sapiens_hsa041222.12057889
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10979405
12One carbon pool by folate_Homo sapiens_hsa006702.01603998
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96043900
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95737385
15Cardiac muscle contraction_Homo sapiens_hsa042601.94085151
16Protein export_Homo sapiens_hsa030601.73734269
17Linoleic acid metabolism_Homo sapiens_hsa005911.73307479
18Fanconi anemia pathway_Homo sapiens_hsa034601.72016883
19Mismatch repair_Homo sapiens_hsa034301.70741167
20Asthma_Homo sapiens_hsa053101.66422344
21DNA replication_Homo sapiens_hsa030301.61611721
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59042292
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57703938
24Nucleotide excision repair_Homo sapiens_hsa034201.55393141
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50619522
26Base excision repair_Homo sapiens_hsa034101.50210453
27RNA degradation_Homo sapiens_hsa030181.48914051
28Basal transcription factors_Homo sapiens_hsa030221.47983877
29Pyrimidine metabolism_Homo sapiens_hsa002401.47562959
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.47514069
31Phototransduction_Homo sapiens_hsa047441.41568676
32Primary immunodeficiency_Homo sapiens_hsa053401.40182305
33Allograft rejection_Homo sapiens_hsa053301.40139409
34Autoimmune thyroid disease_Homo sapiens_hsa053201.38052784
35Folate biosynthesis_Homo sapiens_hsa007901.36277644
36Caffeine metabolism_Homo sapiens_hsa002321.18223218
37Graft-versus-host disease_Homo sapiens_hsa053321.14039168
38Tryptophan metabolism_Homo sapiens_hsa003801.07818259
39Spliceosome_Homo sapiens_hsa030401.07610598
40Nitrogen metabolism_Homo sapiens_hsa009101.02054009
41Sulfur metabolism_Homo sapiens_hsa009201.01832252
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00334242
43Purine metabolism_Homo sapiens_hsa002300.95150903
44Ether lipid metabolism_Homo sapiens_hsa005650.93114313
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92884503
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.92112600
47RNA transport_Homo sapiens_hsa030130.89897280
48Type I diabetes mellitus_Homo sapiens_hsa049400.88667767
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88055380
50Propanoate metabolism_Homo sapiens_hsa006400.87650984
51Arachidonic acid metabolism_Homo sapiens_hsa005900.83212587
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81166901
53Pyruvate metabolism_Homo sapiens_hsa006200.76394150
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76138376
55Selenocompound metabolism_Homo sapiens_hsa004500.76123231
56Fat digestion and absorption_Homo sapiens_hsa049750.75843053
57Antigen processing and presentation_Homo sapiens_hsa046120.74861180
58Metabolic pathways_Homo sapiens_hsa011000.70850165
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70176866
60Chemical carcinogenesis_Homo sapiens_hsa052040.69049825
61Peroxisome_Homo sapiens_hsa041460.67759880
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66203991
63Rheumatoid arthritis_Homo sapiens_hsa053230.65841324
64Vitamin digestion and absorption_Homo sapiens_hsa049770.65645341
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63243406
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62763718
67Collecting duct acid secretion_Homo sapiens_hsa049660.61986758
68Retinol metabolism_Homo sapiens_hsa008300.60779787
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60694379
70Non-homologous end-joining_Homo sapiens_hsa034500.60530054
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60448876
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.60029251
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59676055
74Fatty acid elongation_Homo sapiens_hsa000620.54807650
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52852999
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48269125
77beta-Alanine metabolism_Homo sapiens_hsa004100.45215176
78Butanoate metabolism_Homo sapiens_hsa006500.43125690
79Hematopoietic cell lineage_Homo sapiens_hsa046400.42063659
80Olfactory transduction_Homo sapiens_hsa047400.41560318
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40340301
82Glutathione metabolism_Homo sapiens_hsa004800.39073290
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38784796
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37827785
85Vitamin B6 metabolism_Homo sapiens_hsa007500.36494586
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34943765
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.32855315
88p53 signaling pathway_Homo sapiens_hsa041150.30098148
89Arginine and proline metabolism_Homo sapiens_hsa003300.27416154
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.26452196
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.26342445
92Steroid biosynthesis_Homo sapiens_hsa001000.24464768
93Tyrosine metabolism_Homo sapiens_hsa003500.22608671
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.20634063
95Glycerolipid metabolism_Homo sapiens_hsa005610.18318690
96Epstein-Barr virus infection_Homo sapiens_hsa051690.17475224
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17395312
98Fatty acid degradation_Homo sapiens_hsa000710.15790413
99Cell cycle_Homo sapiens_hsa041100.14881187
100Mineral absorption_Homo sapiens_hsa049780.14833242

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