RPLP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.43183640
2ribosomal small subunit assembly (GO:0000028)8.92495731
3* translational elongation (GO:0006414)8.50459480
4* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.41144878
5* protein targeting to ER (GO:0045047)8.26435925
6* cotranslational protein targeting to membrane (GO:0006613)8.25571008
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.90162572
8* cellular protein complex disassembly (GO:0043624)7.81167082
9* viral life cycle (GO:0019058)7.80293272
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.78705322
11* protein localization to endoplasmic reticulum (GO:0070972)7.69699057
12maturation of SSU-rRNA (GO:0030490)7.46010238
13* translational initiation (GO:0006413)7.40200262
14ribosomal large subunit biogenesis (GO:0042273)7.05302867
15* protein complex disassembly (GO:0043241)6.82641729
16* macromolecular complex disassembly (GO:0032984)6.38729820
17* protein targeting to membrane (GO:0006612)5.52143155
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.43805844
19* translation (GO:0006412)5.20127041
20ribonucleoprotein complex biogenesis (GO:0022613)5.17414236
21* mRNA catabolic process (GO:0006402)5.15112119
22* RNA catabolic process (GO:0006401)4.80395754
23ncRNA 3-end processing (GO:0043628)4.06582592
24rRNA processing (GO:0006364)4.02141965
25DNA deamination (GO:0045006)3.93530753
26formation of translation preinitiation complex (GO:0001731)3.88139956
27rRNA metabolic process (GO:0016072)3.87107025
28cellular component biogenesis (GO:0044085)3.82820474
29* establishment of protein localization to membrane (GO:0090150)3.72895285
30respiratory electron transport chain (GO:0022904)3.47999221
31DNA strand elongation involved in DNA replication (GO:0006271)3.46866350
32* establishment of protein localization to organelle (GO:0072594)3.40992290
33spliceosomal snRNP assembly (GO:0000387)3.40957978
34* protein targeting (GO:0006605)3.40844133
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.40720130
36electron transport chain (GO:0022900)3.37598628
37telomere maintenance via semi-conservative replication (GO:0032201)3.36306314
38DNA strand elongation (GO:0022616)3.25587051
39positive thymic T cell selection (GO:0045059)3.24188498
40positive regulation of gamma-delta T cell activation (GO:0046645)3.19658275
41negative regulation of RNA splicing (GO:0033119)3.15940129
42spliceosomal complex assembly (GO:0000245)3.12092743
43chaperone-mediated protein transport (GO:0072321)3.09226915
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01356922
45viral protein processing (GO:0019082)2.99547776
46DNA replication initiation (GO:0006270)2.97236145
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95628282
48DNA unwinding involved in DNA replication (GO:0006268)2.95506355
49telomere maintenance via recombination (GO:0000722)2.93064674
50protein localization to kinetochore (GO:0034501)2.92828701
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.91785178
52termination of RNA polymerase III transcription (GO:0006386)2.91785178
53DNA replication checkpoint (GO:0000076)2.91102144
54ribosome biogenesis (GO:0042254)2.89778552
55* cellular component disassembly (GO:0022411)2.82824779
56thymic T cell selection (GO:0045061)2.80051054
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79445006
58mitotic recombination (GO:0006312)2.78781898
59ATP synthesis coupled proton transport (GO:0015986)2.78254183
60energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78254183
61* protein localization to membrane (GO:0072657)2.77259453
62folic acid-containing compound biosynthetic process (GO:0009396)2.76542266
63negative T cell selection (GO:0043383)2.76174001
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75617977
65positive T cell selection (GO:0043368)2.72077685
66proteasome assembly (GO:0043248)2.71512609
67negative thymic T cell selection (GO:0045060)2.71058356
68chromatin remodeling at centromere (GO:0031055)2.69686948
69telomere maintenance via telomere lengthening (GO:0010833)2.69421365
70* gene expression (GO:0010467)2.67160158
71kinetochore organization (GO:0051383)2.66458397
72protein localization to chromosome, centromeric region (GO:0071459)2.66318237
73CENP-A containing nucleosome assembly (GO:0034080)2.64605756
74negative regulation of cell killing (GO:0031342)2.64363637
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64363637
76ncRNA processing (GO:0034470)2.64345711
77pseudouridine synthesis (GO:0001522)2.63645104
78nucleotide-excision repair, DNA gap filling (GO:0006297)2.60340288
79establishment of integrated proviral latency (GO:0075713)2.59514539
80UTP biosynthetic process (GO:0006228)2.56675677
81modulation by virus of host process (GO:0019054)2.56147761
82DNA replication-dependent nucleosome organization (GO:0034723)2.54257472
83DNA replication-dependent nucleosome assembly (GO:0006335)2.54257472
84ATP biosynthetic process (GO:0006754)2.54133708
85* protein localization to organelle (GO:0033365)2.53588421
86RNA splicing, via transesterification reactions (GO:0000375)2.52452092
87transcription-coupled nucleotide-excision repair (GO:0006283)2.51576066
88mRNA splicing, via spliceosome (GO:0000398)2.51397540
89RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.51397540
90termination of RNA polymerase II transcription (GO:0006369)2.51238450
91DNA damage response, detection of DNA damage (GO:0042769)2.51053521
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50565907
93kinetochore assembly (GO:0051382)2.50462732
94ribonucleoprotein complex assembly (GO:0022618)2.49862618
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48604456
96myeloid cell homeostasis (GO:0002262)2.48134292
97histone mRNA metabolic process (GO:0008334)2.46968535
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46930732
99leukocyte aggregation (GO:0070486)2.46072990
100mitotic nuclear envelope disassembly (GO:0007077)2.45653190
101regulation of protein heterodimerization activity (GO:0043497)2.45417537
102negative regulation of phagocytosis (GO:0050765)2.45002200
103negative regulation of erythrocyte differentiation (GO:0045647)2.43455210
104T cell selection (GO:0045058)2.43354969
105antigen processing and presentation of endogenous antigen (GO:0019883)2.43208216
106purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.42749098
107ncRNA metabolic process (GO:0034660)2.42475576
108DNA replication-independent nucleosome assembly (GO:0006336)2.42355933
109DNA replication-independent nucleosome organization (GO:0034724)2.42355933
110pyrimidine nucleotide catabolic process (GO:0006244)2.42157005
111positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42072422
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41941420
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.41309312
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40900424
115mitochondrial respiratory chain complex I assembly (GO:0032981)2.40900424
116NADH dehydrogenase complex assembly (GO:0010257)2.40900424
117mitotic metaphase plate congression (GO:0007080)2.40546444
118GTP biosynthetic process (GO:0006183)2.40284838
119inner mitochondrial membrane organization (GO:0007007)2.39853634
120ribosome assembly (GO:0042255)2.38732947
121DNA-templated transcription, termination (GO:0006353)2.37054168
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36823308
123ribonucleoprotein complex subunit organization (GO:0071826)2.36312943
124purine nucleoside triphosphate biosynthetic process (GO:0009145)2.36196447
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.35762443
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34679488
127nucleobase biosynthetic process (GO:0046112)2.34607346
128protein complex biogenesis (GO:0070271)2.33885793
129protein targeting to mitochondrion (GO:0006626)2.32761419
130regulation of mitochondrial translation (GO:0070129)2.31408676
131sequestering of actin monomers (GO:0042989)2.29647539
132oxidative phosphorylation (GO:0006119)2.28850269
133regulation of B cell receptor signaling pathway (GO:0050855)2.28767811
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27891885
135negative regulation of ligase activity (GO:0051352)2.26890699
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.26890699
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.26881487
138ribonucleoside triphosphate biosynthetic process (GO:0009201)2.26676472
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.26157860
140establishment of protein localization to mitochondrion (GO:0072655)2.25173940
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.24324577
142mitochondrial respiratory chain complex assembly (GO:0033108)2.23826381
143regulation of gamma-delta T cell differentiation (GO:0045586)2.22668252
144tolerance induction (GO:0002507)2.22517771
145positive regulation of B cell differentiation (GO:0045579)2.20570376
146guanosine-containing compound biosynthetic process (GO:1901070)2.19767937
147innate immune response in mucosa (GO:0002227)2.18672155
148deoxyribonucleotide catabolic process (GO:0009264)2.18587267
149T cell migration (GO:0072678)2.16772214
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.15916351
151deoxyribose phosphate catabolic process (GO:0046386)2.15906098
152respiratory burst (GO:0045730)2.14490408
153antibacterial humoral response (GO:0019731)2.12132710
154* viral transcription (GO:0019083)10.4680168
155* translational termination (GO:0006415)10.0366220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.15893470
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.76110994
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94513434
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92986938
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.61465943
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.29843503
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.97663374
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.93679660
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.92688704
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89600317
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86126726
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81511621
13* XRN2_22483619_ChIP-Seq_HELA_Human2.78744112
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75519803
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73428980
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72145877
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48191004
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44923213
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.44216176
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36925927
21TTF2_22483619_ChIP-Seq_HELA_Human2.28350256
22DCP1A_22483619_ChIP-Seq_HELA_Human2.18040036
23* VDR_23849224_ChIP-Seq_CD4+_Human2.15436362
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08093428
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92607023
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92472702
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91819417
28FOXP3_21729870_ChIP-Seq_TREG_Human1.89557156
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85652454
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82191708
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80275117
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79485369
33MYC_22102868_ChIP-Seq_BL_Human1.78758656
34ELK1_19687146_ChIP-ChIP_HELA_Human1.75038738
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70336729
36VDR_21846776_ChIP-Seq_THP-1_Human1.70293903
37* LXR_22292898_ChIP-Seq_THP-1_Human1.61095647
38GABP_19822575_ChIP-Seq_HepG2_Human1.60166061
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56106526
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55855038
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51715430
42* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46849398
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45887738
44* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45484644
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.45155943
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45109491
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42452655
48* E2F1_21310950_ChIP-Seq_MCF-7_Human1.41866326
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41551026
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.40789074
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.39971559
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39795871
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38933842
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.37695378
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37349464
56CIITA_25753668_ChIP-Seq_RAJI_Human1.36467380
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.35665376
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34134160
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33963432
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33002673
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31776105
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31142448
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30810257
64* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29744535
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29465572
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27595817
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26846890
68KDM5A_27292631_Chip-Seq_BREAST_Human1.26793386
69CTCF_26484167_Chip-Seq_Bcells_Mouse1.26279087
70* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26132689
71* P68_20966046_ChIP-Seq_HELA_Human1.23966666
72AR_21909140_ChIP-Seq_LNCAP_Human1.23151535
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23077756
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22796863
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22796863
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22796863
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22636641
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22522418
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.22348094
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21872220
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.20997351
82KDM2B_26808549_Chip-Seq_DND41_Human1.20549476
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20461286
84* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20108007
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19054063
86BCL6_27268052_Chip-Seq_Bcells_Human1.18814427
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18405699
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18013901
89MYC_18940864_ChIP-ChIP_HL60_Human1.17661518
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17240840
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16366975
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14101125
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13373351
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12900130
95TCF7_22412390_ChIP-Seq_EML_Mouse1.10975907
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10776890
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10142535
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09934296
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.09137291
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06990390
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06966817
102SPI1_23547873_ChIP-Seq_NB4_Human1.06705418
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.05535245
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.05085870
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04160797
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03853272
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03828571
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03764631
109* BCOR_27268052_Chip-Seq_Bcells_Human1.03160401
110* NCOR1_26117541_ChIP-Seq_K562_Human1.03079373
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01708237
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.01263388
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00211176
114ZNF263_19887448_ChIP-Seq_K562_Human1.00036944
115MAF_26560356_Chip-Seq_TH2_Human1.00023778
116CTCF_21964334_Chip-Seq_Bcells_Human0.99779825
117* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99064917
118MYB_26560356_Chip-Seq_TH2_Human0.98834011
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.98626836
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97462727
121RACK7_27058665_Chip-Seq_MCF-7_Human0.97341633
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96763398
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96130189
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96082757
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95642600
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95594318
127UTX_26944678_Chip-Seq_JUKART_Human0.95295792
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93102736
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92768485
130* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90705227
131MAF_26560356_Chip-Seq_TH1_Human0.89981978
132* SRF_21415370_ChIP-Seq_HL-1_Mouse0.89521082
133VDR_24763502_ChIP-Seq_THP-1_Human0.89181733
134TFEB_21752829_ChIP-Seq_HELA_Human0.89015798
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88460940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.28264074
2MP0003693_abnormal_embryo_hatching4.25324841
3MP0004957_abnormal_blastocyst_morpholog3.67669920
4MP0003111_abnormal_nucleus_morphology2.93738931
5MP0003077_abnormal_cell_cycle2.80250509
6MP0010094_abnormal_chromosome_stability2.78529685
7MP0008932_abnormal_embryonic_tissue2.35140407
8MP0003941_abnormal_skin_development2.05517716
9MP0008007_abnormal_cellular_replicative2.01324804
10MP0001790_abnormal_immune_system1.94046512
11MP0005387_immune_system_phenotype1.94046512
12MP0006292_abnormal_olfactory_placode1.91982507
13MP0008057_abnormal_DNA_replication1.90937149
14MP0002396_abnormal_hematopoietic_system1.90339466
15MP0001873_stomach_inflammation1.89400512
16MP0009333_abnormal_splenocyte_physiolog1.78978775
17MP0000490_abnormal_crypts_of1.77793437
18MP0008058_abnormal_DNA_repair1.74354284
19MP0003303_peritoneal_inflammation1.74248115
20MP0010030_abnormal_orbit_morphology1.73679399
21MP0003763_abnormal_thymus_physiology1.70554836
22MP0008995_early_reproductive_senescence1.70000181
23MP0002163_abnormal_gland_morphology1.69848589
24MP0000350_abnormal_cell_proliferation1.65410623
25MP0003786_premature_aging1.63011982
26MP0010352_gastrointestinal_tract_polyps1.57346420
27MP0003186_abnormal_redox_activity1.56152714
28MP0005075_abnormal_melanosome_morpholog1.54449910
29MP0001730_embryonic_growth_arrest1.54066696
30MP0003806_abnormal_nucleotide_metabolis1.47376233
31MP0003123_paternal_imprinting1.43379812
32MP0000566_synostosis1.42537494
33MP0004808_abnormal_hematopoietic_stem1.40408410
34MP0005501_abnormal_skin_physiology1.34872781
35MP0002419_abnormal_innate_immunity1.33211798
36MP0002796_impaired_skin_barrier1.32702395
37MP0000703_abnormal_thymus_morphology1.29377654
38MP0000372_irregular_coat_pigmentation1.29309316
39MP0003315_abnormal_perineum_morphology1.27901253
40MP0002132_abnormal_respiratory_system1.22952764
41MP0000858_altered_metastatic_potential1.21127161
42MP0002019_abnormal_tumor_incidence1.20866361
43MP0009053_abnormal_anal_canal1.19768687
44MP0009785_altered_susceptibility_to1.19506670
45MP0002398_abnormal_bone_marrow1.18993770
46MP0005076_abnormal_cell_differentiation1.18644402
47MP0001697_abnormal_embryo_size1.18464650
48MP0004381_abnormal_hair_follicle1.17498620
49MP0003136_yellow_coat_color1.16064375
50MP0002722_abnormal_immune_system1.14857148
51MP0005174_abnormal_tail_pigmentation1.14542050
52MP0000313_abnormal_cell_death1.13853549
53MP0002080_prenatal_lethality1.13419590
54MP0001663_abnormal_digestive_system1.12883008
55MP0001800_abnormal_humoral_immune1.12565197
56MP0003567_abnormal_fetal_cardiomyocyte1.12517575
57MP0005666_abnormal_adipose_tissue1.11143920
58MP0002085_abnormal_embryonic_tissue1.10222592
59MP0005380_embryogenesis_phenotype1.06962392
60MP0001672_abnormal_embryogenesis/_devel1.06962392
61MP0004947_skin_inflammation1.06576708
62MP0000685_abnormal_immune_system1.05776960
63MP0003724_increased_susceptibility_to1.05555461
64MP0003436_decreased_susceptibility_to1.02463016
65MP0005397_hematopoietic_system_phenotyp1.02311375
66MP0001545_abnormal_hematopoietic_system1.02311375
67MP0000689_abnormal_spleen_morphology1.01875035
68MP0000750_abnormal_muscle_regeneration0.97646566
69MP0003011_delayed_dark_adaptation0.97449492
70MP0001845_abnormal_inflammatory_respons0.97365060
71MP0004185_abnormal_adipocyte_glucose0.97115792
72MP0002088_abnormal_embryonic_growth/wei0.96105615
73MP0002405_respiratory_system_inflammati0.96081488
74MP0005451_abnormal_body_composition0.95467729
75MP0002429_abnormal_blood_cell0.95226946
76MP0003984_embryonic_growth_retardation0.95072568
77MP0002084_abnormal_developmental_patter0.94656384
78MP0002420_abnormal_adaptive_immunity0.94446463
79MP0002452_abnormal_antigen_presenting0.94261394
80MP0002095_abnormal_skin_pigmentation0.93589736
81MP0003828_pulmonary_edema0.93536686
82MP0001819_abnormal_immune_cell0.92927219
83MP0003959_abnormal_lean_body0.92394714
84MP0002086_abnormal_extraembryonic_tissu0.92356257
85MP0006036_abnormal_mitochondrial_physio0.91493008
86MP0005023_abnormal_wound_healing0.90997972
87MP0002060_abnormal_skin_morphology0.90551478
88MP0003453_abnormal_keratinocyte_physiol0.89683411
89MP0000049_abnormal_middle_ear0.89505237
90MP0000716_abnormal_immune_system0.89419727
91MP0001216_abnormal_epidermal_layer0.88501105
92MP0002166_altered_tumor_susceptibility0.88209855
93MP0003718_maternal_effect0.87259666
94MP0003566_abnormal_cell_adhesion0.87247622
95MP0002933_joint_inflammation0.87236699
96MP0002249_abnormal_larynx_morphology0.86416846
97MP0004197_abnormal_fetal_growth/weight/0.86195872
98MP0001346_abnormal_lacrimal_gland0.85709732
99MP0005000_abnormal_immune_tolerance0.85558645
100MP0005381_digestive/alimentary_phenotyp0.85139592
101MP0010155_abnormal_intestine_physiology0.84513091
102MP0005377_hearing/vestibular/ear_phenot0.84508256
103MP0003878_abnormal_ear_physiology0.84508256
104MP0002723_abnormal_immune_serum0.83803699
105MP0008961_abnormal_basal_metabolism0.83607693
106MP0002148_abnormal_hypersensitivity_rea0.83230285
107MP0000678_abnormal_parathyroid_gland0.81035916
108MP0001835_abnormal_antigen_presentation0.80990601
109MP0000465_gastrointestinal_hemorrhage0.80752817
110MP0005464_abnormal_platelet_physiology0.80474137
111MP0001853_heart_inflammation0.79448349
112MP0004858_abnormal_nervous_system0.78954466
113MP0002653_abnormal_ependyma_morphology0.78413564
114MP0002006_tumorigenesis0.77771050
115MP0005025_abnormal_response_to0.77431972
116MP0001851_eye_inflammation0.77267063
117MP0001533_abnormal_skeleton_physiology0.77138601
118MP0002111_abnormal_tail_morphology0.76943260
119MP0009278_abnormal_bone_marrow0.76932095
120MP0003866_abnormal_defecation0.76721008
121MP0000537_abnormal_urethra_morphology0.76670043
122MP0008469_abnormal_protein_level0.75997511
123MP0002938_white_spotting0.75235903
124MP0005671_abnormal_response_to0.72995731
125MP0000762_abnormal_tongue_morphology0.72871552
126MP0002098_abnormal_vibrissa_morphology0.72216118
127MP0003448_altered_tumor_morphology0.72039997
128MP0000477_abnormal_intestine_morphology0.70947819
129MP0009931_abnormal_skin_appearance0.69020307
130MP0002277_abnormal_respiratory_mucosa0.68994336
131MP0003938_abnormal_ear_development0.67391870
132MP0008260_abnormal_autophagy0.66871731
133MP0001727_abnormal_embryo_implantation0.66855198
134MP0010771_integument_phenotype0.66699099
135MP0002210_abnormal_sex_determination0.66302025
136MP0006054_spinal_hemorrhage0.66267864
137MP0005058_abnormal_lysosome_morphology0.66197859
138MP0006035_abnormal_mitochondrial_morpho0.66160555
139MP0001286_abnormal_eye_development0.65412281
140MP0001243_abnormal_dermal_layer0.65228700
141MP0001881_abnormal_mammary_gland0.60311101
142MP0005379_endocrine/exocrine_gland_phen0.59169610

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.70735248
2Reticulocytopenia (HP:0001896)8.37350173
3Abnormal number of erythroid precursors (HP:0012131)7.73373030
4Macrocytic anemia (HP:0001972)6.56905706
5Pallor (HP:0000980)6.02439238
6Abnormal hemoglobin (HP:0011902)4.38042708
7Aplasia/Hypoplasia of the sacrum (HP:0008517)4.05081229
8Trismus (HP:0000211)3.38188133
9Colon cancer (HP:0003003)3.20140570
10Thrombocytosis (HP:0001894)3.19209273
11Eczematoid dermatitis (HP:0000976)3.11141241
12Absent thumb (HP:0009777)3.10518868
13Congenital, generalized hypertrichosis (HP:0004540)2.98146608
14Panhypogammaglobulinemia (HP:0003139)2.94567722
15Increased IgE level (HP:0003212)2.90661365
16Depressed nasal ridge (HP:0000457)2.85882593
17Breast hypoplasia (HP:0003187)2.82750143
18Abnormality of reticulocytes (HP:0004312)2.82229642
19Agammaglobulinemia (HP:0004432)2.76049463
20Abnormality of the parietal bone (HP:0002696)2.70963187
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65544046
22Increased hepatocellular lipid droplets (HP:0006565)2.65103526
23Multiple enchondromatosis (HP:0005701)2.63332710
2411 pairs of ribs (HP:0000878)2.60813483
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58764861
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58764861
27Sparse lateral eyebrow (HP:0005338)2.54748404
28Oral leukoplakia (HP:0002745)2.52683953
29Triphalangeal thumb (HP:0001199)2.52094418
30Colitis (HP:0002583)2.51262976
31Recurrent bacterial skin infections (HP:0005406)2.49000481
32Concave nail (HP:0001598)2.48493006
33Gastrointestinal stroma tumor (HP:0100723)2.46921296
34Meningitis (HP:0001287)2.46496647
35Exertional dyspnea (HP:0002875)2.44750398
36Recurrent abscess formation (HP:0002722)2.43075035
37Rough bone trabeculation (HP:0100670)2.42639213
38Thick lower lip vermilion (HP:0000179)2.41603075
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.41079482
40Woolly hair (HP:0002224)2.39505607
41Gastrointestinal inflammation (HP:0004386)2.38284929
42Migraine (HP:0002076)2.33539658
43Aplastic anemia (HP:0001915)2.30947714
44Mitochondrial inheritance (HP:0001427)2.29175589
45Mediastinal lymphadenopathy (HP:0100721)2.28901486
46Hypoplasia of the radius (HP:0002984)2.27507744
47Lymphopenia (HP:0001888)2.27497400
48Hypertensive crisis (HP:0100735)2.22969800
49Lipid accumulation in hepatocytes (HP:0006561)2.21246636
50Recurrent fungal infections (HP:0002841)2.20296593
51Atresia of the external auditory canal (HP:0000413)2.19890109
52Microvesicular hepatic steatosis (HP:0001414)2.19564433
53Stenosis of the external auditory canal (HP:0000402)2.18984978
54Selective tooth agenesis (HP:0001592)2.18720655
55Inflammation of the large intestine (HP:0002037)2.17870174
56Acute necrotizing encephalopathy (HP:0006965)2.16448638
57Cellulitis (HP:0100658)2.15573634
58Recurrent viral infections (HP:0004429)2.14661323
59Exercise intolerance (HP:0003546)2.12393961
60Cerebral edema (HP:0002181)2.11987272
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11211178
62Cleft eyelid (HP:0000625)2.10345143
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.09928254
64Broad distal phalanx of finger (HP:0009836)2.08070840
65Asplenia (HP:0001746)2.07752768
66Carpal bone hypoplasia (HP:0001498)2.06720612
67Patellar aplasia (HP:0006443)2.05354725
68Down-sloping shoulders (HP:0200021)2.03586941
69Papilloma (HP:0012740)2.03078883
70Verrucae (HP:0200043)2.03078883
71Birth length less than 3rd percentile (HP:0003561)2.02872206
72Horseshoe kidney (HP:0000085)2.01181375
73Pustule (HP:0200039)2.00487597
74Hepatocellular necrosis (HP:0001404)1.99484747
75Aplasia/Hypoplasia of the patella (HP:0006498)1.98697449
76Abnormality of the heme biosynthetic pathway (HP:0010472)1.97429919
77Myositis (HP:0100614)1.97420476
78Abnormality of T cells (HP:0002843)1.96596386
79Partial duplication of the phalanx of hand (HP:0009999)1.96524328
80Abnormality of macrophages (HP:0004311)1.93874369
81Sparse eyelashes (HP:0000653)1.92639923
82Basal cell carcinoma (HP:0002671)1.91816784
83Abnormality of T cell physiology (HP:0011840)1.91736277
84Encephalitis (HP:0002383)1.91297477
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.89644931
86Missing ribs (HP:0000921)1.89068710
87Secondary amenorrhea (HP:0000869)1.88959382
88Fragile nails (HP:0001808)1.88814312
89Lactic acidosis (HP:0003128)1.87637831
90Abnormal mitochondria in muscle tissue (HP:0008316)1.87618723
91Nasolacrimal duct obstruction (HP:0000579)1.86898923
92Increased CSF lactate (HP:0002490)1.86600460
93Microretrognathia (HP:0000308)1.86026697
94Neoplasm of the pancreas (HP:0002894)1.85631548
95Pancytopenia (HP:0001876)1.84863372
96Respiratory difficulties (HP:0002880)1.84143949
97IgM deficiency (HP:0002850)1.82159741
98Increased intramyocellular lipid droplets (HP:0012240)1.80581176
99Absent radius (HP:0003974)1.80449623
100Recurrent cutaneous fungal infections (HP:0011370)1.80027091
101Chronic mucocutaneous candidiasis (HP:0002728)1.80027091
102Hypochromic anemia (HP:0001931)1.79280691
103Abnormality of the preputium (HP:0100587)1.78801149
104Increased IgM level (HP:0003496)1.78710085
105Supernumerary ribs (HP:0005815)1.78282636
106Glossoptosis (HP:0000162)1.77332890
107Septo-optic dysplasia (HP:0100842)1.76958754
108Seborrheic dermatitis (HP:0001051)1.75885838
109Premature ovarian failure (HP:0008209)1.75513316
110Microcytic anemia (HP:0001935)1.75415773
111Recurrent skin infections (HP:0001581)1.73650494
112Premature rupture of membranes (HP:0001788)1.72614392
113Stomatitis (HP:0010280)1.72592487
114Neutropenia (HP:0001875)1.72464502
115Vasculitis (HP:0002633)1.71855425
116Abnormal number of incisors (HP:0011064)1.71766238
117Gastrointestinal infarctions (HP:0005244)1.70686202
118Premature graying of hair (HP:0002216)1.70528379
119Aplasia/Hypoplasia of the thymus (HP:0010515)1.68969669
120Myelodysplasia (HP:0002863)1.68444960
121Abnormal trabecular bone morphology (HP:0100671)1.68075751
122Abnormality of renal resorption (HP:0011038)1.67847065
123Progressive macrocephaly (HP:0004481)1.67297262
124Supernumerary bones of the axial skeleton (HP:0009144)1.66186146
125Protrusio acetabuli (HP:0003179)1.65615539
126Absent forearm bone (HP:0003953)1.65406786
127Aplasia involving forearm bones (HP:0009822)1.65406786
128Nasal polyposis (HP:0100582)1.63238432
129Partial duplication of thumb phalanx (HP:0009944)1.62561930
130Respiratory failure (HP:0002878)1.62370343
131Meckel diverticulum (HP:0002245)1.60877513
132Tracheoesophageal fistula (HP:0002575)1.59732870
133Abnormality of abdominal situs (HP:0011620)1.59258413
134Abdominal situs inversus (HP:0003363)1.59258413
135Renal Fanconi syndrome (HP:0001994)1.57215392
136Abnormality of the ileum (HP:0001549)1.54789213
137Hepatic necrosis (HP:0002605)1.54018647
138Progressive muscle weakness (HP:0003323)1.53803061
139Elevated erythrocyte sedimentation rate (HP:0003565)1.53788966
140Angiofibromas (HP:0010615)1.52259321
141Adenoma sebaceum (HP:0009720)1.52259321
142Increased density of long bones (HP:0006392)1.51440620
143Rhabdomyosarcoma (HP:0002859)1.50737236
1443-Methylglutaconic aciduria (HP:0003535)1.50227616
145Proximal placement of thumb (HP:0009623)1.49908571
146Obstructive lung disease (HP:0006536)1.49694104
147Chronic obstructive pulmonary disease (HP:0006510)1.49694104
148Increased serum lactate (HP:0002151)1.48618292
149Rectal prolapse (HP:0002035)1.48517512
150Poikiloderma (HP:0001029)1.47946089
151Increased muscle lipid content (HP:0009058)1.47402437
152Acute encephalopathy (HP:0006846)1.46164988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.78801715
2TLK14.43525250
3VRK23.70100063
4BUB13.65928990
5WEE13.01669304
6EIF2AK12.83215463
7PRPF4B2.42226280
8PIM22.33619301
9ERN12.24200706
10RPS6KB22.16720735
11EEF2K2.10598980
12TESK22.08970572
13LRRK22.05158911
14SMG12.01649555
15RIPK41.98746722
16SRPK11.98032211
17MAP3K101.88077155
18CDC71.86306760
19MAP4K11.79073159
20IRAK41.77562287
21DYRK31.77295429
22NEK21.75628826
23VRK11.60068349
24RPS6KA41.54057949
25TXK1.49183468
26CDK71.47245135
27AURKB1.44651204
28TGFBR11.39647769
29STK161.38214027
30MST41.36647187
31MKNK11.31489441
32MKNK21.29961026
33BLK1.29768323
34PKN21.27263598
35PLK11.26430140
36ARAF1.24193475
37ILK1.23649058
38PAK41.20578432
39STK101.19260355
40TTK1.17846617
41NME11.16566423
42MAP3K81.16370028
43TAOK21.14361378
44AURKA1.12107524
45SIK11.11109988
46MAP3K111.10808510
47PASK1.08133735
48MAP3K131.04126065
49PIM11.01630987
50EIF2AK30.99453622
51IKBKE0.98414585
52CDK40.98098468
53SYK0.97835038
54ITK0.97479686
55DAPK30.96397011
56JAK30.92951962
57BRSK20.90315139
58MAP2K20.90221110
59ACVR1B0.88965457
60MARK30.88723961
61EPHA20.88453592
62STK40.87338391
63TSSK60.85692005
64FLT30.85256335
65CDK80.85175701
66RPS6KA50.83463019
67TNK20.82529133
68MAPKAPK30.81610611
69BCKDK0.80659746
70KDR0.80136722
71CDK190.79478709
72CLK10.78264089
73TAOK30.78070295
74PBK0.76759401
75TEC0.75283400
76PTK60.75059479
77ZAP700.74575833
78ATR0.74222783
79BTK0.74104558
80PAK10.74019369
81GRK60.73478607
82* CSNK2A20.73198746
83ICK0.70845435
84IRAK20.70763761
85TESK10.70382251
86HCK0.70123623
87FES0.68953968
88SCYL20.68436723
89IKBKB0.67697509
90CHEK20.67616990
91MAPK150.66805649
92CDK90.66368255
93PLK40.65613184
94NEK90.65475826
95EPHB20.64306631
96CSNK2A10.64138959
97TRIB30.63384484
98LIMK10.62825743
99CHEK10.61923649
100NLK0.61320917
101TYRO30.60666209
102HIPK20.58524300
103ALK0.57310636
104CDK60.56381059
105TAOK10.56314565
106KIT0.55233628
107SIK20.54197403
108MARK20.54132087
109CSF1R0.51159790
110MAP3K30.50899295
111TYK20.50893055
112DYRK1B0.49094162
113DYRK20.48219476
114PRKCI0.48190195
115LCK0.47928815
116CDK20.47290225
117CSK0.47115146
118MAP3K10.45545645
119ATM0.44091881
120RPS6KL10.44027881
121RPS6KC10.44027881
122PRKCQ0.43974943
123BMX0.42825832
124BRAF0.42820753
125MAPK120.42805628
126PAK20.42733579
127TAF10.40940929
128EIF2AK20.39426645
129CDK120.39325852
130RPS6KA60.38869444
131CAMKK10.38812100
132MOS0.38644008
133LYN0.38074757
134MELK0.36832980
135IRAK30.36103649
136MAPKAPK20.36016539
137TBK10.35286025
138MAP2K30.33713036
139ABL20.33028469

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.02624059
2DNA replication_Homo sapiens_hsa030303.63497474
3RNA polymerase_Homo sapiens_hsa030203.11752468
4Spliceosome_Homo sapiens_hsa030403.06747814
5Mismatch repair_Homo sapiens_hsa034303.05976363
6Proteasome_Homo sapiens_hsa030502.71672579
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60116395
8Homologous recombination_Homo sapiens_hsa034402.50927180
9RNA transport_Homo sapiens_hsa030132.26478262
10Nucleotide excision repair_Homo sapiens_hsa034202.24522459
11Base excision repair_Homo sapiens_hsa034102.19279087
12Pyrimidine metabolism_Homo sapiens_hsa002402.16601603
13Oxidative phosphorylation_Homo sapiens_hsa001901.98534514
14One carbon pool by folate_Homo sapiens_hsa006701.98353071
15Parkinsons disease_Homo sapiens_hsa050121.95223489
16Cell cycle_Homo sapiens_hsa041101.67426598
17Huntingtons disease_Homo sapiens_hsa050161.57852975
18Fanconi anemia pathway_Homo sapiens_hsa034601.50831763
19Protein export_Homo sapiens_hsa030601.49650957
20Autoimmune thyroid disease_Homo sapiens_hsa053201.48902040
21Sulfur relay system_Homo sapiens_hsa041221.43000292
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42069015
23Basal transcription factors_Homo sapiens_hsa030221.41210968
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34607822
25p53 signaling pathway_Homo sapiens_hsa041151.33632160
26RNA degradation_Homo sapiens_hsa030181.28418671
27Non-homologous end-joining_Homo sapiens_hsa034501.27895515
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24230913
29Alzheimers disease_Homo sapiens_hsa050101.21293487
30Systemic lupus erythematosus_Homo sapiens_hsa053221.18144389
31Primary immunodeficiency_Homo sapiens_hsa053401.16915154
32mRNA surveillance pathway_Homo sapiens_hsa030151.16608448
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.10607059
34Epstein-Barr virus infection_Homo sapiens_hsa051691.08329541
35Antigen processing and presentation_Homo sapiens_hsa046121.03855764
36Herpes simplex infection_Homo sapiens_hsa051680.95538694
37Purine metabolism_Homo sapiens_hsa002300.90471410
38HTLV-I infection_Homo sapiens_hsa051660.75805373
39Thyroid cancer_Homo sapiens_hsa052160.74673340
40Type I diabetes mellitus_Homo sapiens_hsa049400.74202742
41Viral carcinogenesis_Homo sapiens_hsa052030.73636343
42Bladder cancer_Homo sapiens_hsa052190.72127601
43Hematopoietic cell lineage_Homo sapiens_hsa046400.68680942
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67927911
45Non-small cell lung cancer_Homo sapiens_hsa052230.65927356
46Small cell lung cancer_Homo sapiens_hsa052220.63940260
47Folate biosynthesis_Homo sapiens_hsa007900.62357297
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60448178
49Staphylococcus aureus infection_Homo sapiens_hsa051500.59024849
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56967047
51Acute myeloid leukemia_Homo sapiens_hsa052210.56232294
52Apoptosis_Homo sapiens_hsa042100.56221604
53Basal cell carcinoma_Homo sapiens_hsa052170.56109114
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.53672488
55Cardiac muscle contraction_Homo sapiens_hsa042600.53305679
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52880357
57Pentose phosphate pathway_Homo sapiens_hsa000300.52865870
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51495195
59Measles_Homo sapiens_hsa051620.49738679
60MicroRNAs in cancer_Homo sapiens_hsa052060.49422942
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.49334631
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47440406
63VEGF signaling pathway_Homo sapiens_hsa043700.47226632
64Chronic myeloid leukemia_Homo sapiens_hsa052200.46675829
65Glutathione metabolism_Homo sapiens_hsa004800.44251025
66Shigellosis_Homo sapiens_hsa051310.43249631
67Legionellosis_Homo sapiens_hsa051340.43187361
68Hepatitis B_Homo sapiens_hsa051610.41954741
69Pancreatic cancer_Homo sapiens_hsa052120.41546790
70TGF-beta signaling pathway_Homo sapiens_hsa043500.41418520
71Notch signaling pathway_Homo sapiens_hsa043300.39836257
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39453319
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39395178
74Alcoholism_Homo sapiens_hsa050340.38029160
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.37542665
76B cell receptor signaling pathway_Homo sapiens_hsa046620.36869314
77Viral myocarditis_Homo sapiens_hsa054160.36267990
78Pathways in cancer_Homo sapiens_hsa052000.35822051
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35787711
80Chemokine signaling pathway_Homo sapiens_hsa040620.35657187
81Leishmaniasis_Homo sapiens_hsa051400.34923744
82Tuberculosis_Homo sapiens_hsa051520.34103452
83Arachidonic acid metabolism_Homo sapiens_hsa005900.33820267
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33534846
85Graft-versus-host disease_Homo sapiens_hsa053320.33350293
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33309123
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.33119215
88HIF-1 signaling pathway_Homo sapiens_hsa040660.32945037
89T cell receptor signaling pathway_Homo sapiens_hsa046600.32453031
90Hippo signaling pathway_Homo sapiens_hsa043900.30127985
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30081695
92Oocyte meiosis_Homo sapiens_hsa041140.29738472
93Other glycan degradation_Homo sapiens_hsa005110.29412660
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28630446
95Hedgehog signaling pathway_Homo sapiens_hsa043400.28338449
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27450707
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27363148
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26378420
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26056950
100Malaria_Homo sapiens_hsa051440.25969147
101Asthma_Homo sapiens_hsa053100.25243777
102Melanoma_Homo sapiens_hsa052180.24718883
103Rheumatoid arthritis_Homo sapiens_hsa053230.24238685
104Renal cell carcinoma_Homo sapiens_hsa052110.24015714
105Metabolic pathways_Homo sapiens_hsa011000.22364417
106Influenza A_Homo sapiens_hsa051640.21833218
107Colorectal cancer_Homo sapiens_hsa052100.21645052
108Prostate cancer_Homo sapiens_hsa052150.20655516
109Allograft rejection_Homo sapiens_hsa053300.20517984
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19755217
111Toxoplasmosis_Homo sapiens_hsa051450.19540363
112Galactose metabolism_Homo sapiens_hsa000520.19322904
113Proteoglycans in cancer_Homo sapiens_hsa052050.18877581
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.17469897
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17328823
116Fructose and mannose metabolism_Homo sapiens_hsa000510.15793503
117Wnt signaling pathway_Homo sapiens_hsa043100.15418979
118Osteoclast differentiation_Homo sapiens_hsa043800.14979793
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13026843
120Vitamin digestion and absorption_Homo sapiens_hsa049770.11020863

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