RPLP2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.76620387
2regulation of germinal center formation (GO:0002634)5.52244207
3negative regulation of telomere maintenance (GO:0032205)5.00021548
4maturation of 5.8S rRNA (GO:0000460)4.80279534
5behavioral response to nicotine (GO:0035095)4.24039364
6protein K63-linked deubiquitination (GO:0070536)4.14111957
7cellular response to ATP (GO:0071318)4.12982072
8sleep (GO:0030431)4.09286938
9negative regulation of B cell apoptotic process (GO:0002903)3.99776931
10positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.86242637
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.84357824
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.84357824
13negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.80656065
14maturation of SSU-rRNA (GO:0030490)3.73224599
15multicellular organism reproduction (GO:0032504)3.69248815
16ubiquinone biosynthetic process (GO:0006744)3.60422731
17regulation of hypersensitivity (GO:0002883)3.59425273
18growth hormone receptor signaling pathway (GO:0060396)3.52389048
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.48750108
20natural killer cell activation involved in immune response (GO:0002323)3.44252673
21negative regulation of cell killing (GO:0031342)3.41602309
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41602309
23protein-cofactor linkage (GO:0018065)3.35998825
24dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.35235673
25rRNA catabolic process (GO:0016075)3.33242627
26ubiquinone metabolic process (GO:0006743)3.31438603
27trivalent inorganic anion homeostasis (GO:0072506)3.29279573
28phosphate ion homeostasis (GO:0055062)3.29279573
29negative regulation of DNA-templated transcription, elongation (GO:0032785)3.27397951
30cellular response to growth hormone stimulus (GO:0071378)3.23487223
31GDP-mannose metabolic process (GO:0019673)3.23352863
32positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22568905
33respiratory tube development (GO:0030323)3.15725833
34mannosylation (GO:0097502)3.15245697
35regulation of T cell mediated cytotoxicity (GO:0001914)3.14658781
36magnesium ion transport (GO:0015693)3.14577274
37regulation of prostaglandin secretion (GO:0032306)3.13804305
38lung epithelium development (GO:0060428)3.12310809
39cellular ketone body metabolic process (GO:0046950)3.04029981
40indolalkylamine metabolic process (GO:0006586)3.03701714
41negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00900651
42negative regulation of T-helper cell differentiation (GO:0045623)3.00900651
43kidney morphogenesis (GO:0060993)3.00770832
44cellular response to zinc ion (GO:0071294)2.99398146
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98414514
46negative regulation of reactive oxygen species metabolic process (GO:2000378)2.97939356
47adenosine metabolic process (GO:0046085)2.97625362
48base-excision repair, AP site formation (GO:0006285)2.97426095
49positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.97110477
50estrogen biosynthetic process (GO:0006703)2.96785168
51termination of RNA polymerase III transcription (GO:0006386)2.96398394
52transcription elongation from RNA polymerase III promoter (GO:0006385)2.96398394
53positive regulation of cell fate commitment (GO:0010455)2.91540660
54DNA excision (GO:0044349)2.91057550
55nucleotide-excision repair, DNA damage removal (GO:0000718)2.91057550
56negative regulation of lymphocyte apoptotic process (GO:0070229)2.89894826
57dopamine transport (GO:0015872)2.89760434
58positive regulation of prostaglandin secretion (GO:0032308)2.88696349
59regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.84510529
60response to interleukin-15 (GO:0070672)2.83017848
61positive regulation of T-helper 1 type immune response (GO:0002827)2.82839681
62quinone biosynthetic process (GO:1901663)2.81815045
63protein K48-linked deubiquitination (GO:0071108)2.81557343
64axoneme assembly (GO:0035082)2.80256477
65alkaloid metabolic process (GO:0009820)2.79263967
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74983936
67negative regulation of JAK-STAT cascade (GO:0046426)2.74787605
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71572446
69regulation of B cell receptor signaling pathway (GO:0050855)2.68474368
70water-soluble vitamin biosynthetic process (GO:0042364)2.68154422
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68033402
72ketone body metabolic process (GO:1902224)2.66298375
73cellular response to interleukin-15 (GO:0071350)2.65109086
74UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64780236
75regulation of T-helper 1 type immune response (GO:0002825)2.62616085
76ether lipid metabolic process (GO:0046485)2.61248629
77protein K11-linked deubiquitination (GO:0035871)2.60370220
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60085208
79positive regulation of T cell mediated immunity (GO:0002711)2.59448787
80regulation of defense response to virus by host (GO:0050691)2.55202179
81L-fucose catabolic process (GO:0042355)2.54314081
82fucose catabolic process (GO:0019317)2.54314081
83L-fucose metabolic process (GO:0042354)2.54314081
84ribosomal small subunit assembly (GO:0000028)2.54249897
85peptidyl-histidine modification (GO:0018202)2.53019978
86preassembly of GPI anchor in ER membrane (GO:0016254)2.51757158
87purine deoxyribonucleotide catabolic process (GO:0009155)2.49748131
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48738393
89cartilage morphogenesis (GO:0060536)2.48253626
90mitotic cell cycle arrest (GO:0071850)2.47033842
91negative regulation of alpha-beta T cell differentiation (GO:0046639)2.45174567
92positive regulation of activated T cell proliferation (GO:0042104)2.44533050
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44301476
94response to interferon-beta (GO:0035456)2.44111882
95positive regulation of defense response to virus by host (GO:0002230)2.41915035
96positive regulation of meiosis (GO:0045836)2.41086103
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40169548
98iron-sulfur cluster assembly (GO:0016226)2.38301811
99metallo-sulfur cluster assembly (GO:0031163)2.38301811
100response to xenobiotic stimulus (GO:0009410)2.37444612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.15354189
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77958737
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.25496572
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06582635
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.85174472
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82829787
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.59841488
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47742898
9ZNF274_21170338_ChIP-Seq_K562_Hela2.40703324
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.16031684
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09040306
12VDR_23849224_ChIP-Seq_CD4+_Human2.06591092
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03359386
14IGF1R_20145208_ChIP-Seq_DFB_Human2.01013769
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96553303
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96454393
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86635089
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85840707
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84012629
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.78519244
21IRF1_19129219_ChIP-ChIP_H3396_Human1.75386471
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.67464899
23MYC_18940864_ChIP-ChIP_HL60_Human1.67405262
24STAT1_20625510_ChIP-Seq_HELA_Human1.67318885
25GATA3_26560356_Chip-Seq_TH2_Human1.67214827
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65736385
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60821581
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58010589
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.57296857
30MYB_26560356_Chip-Seq_TH2_Human1.56450430
31RUNX_20019798_ChIP-Seq_JUKART_Human1.54626653
32CIITA_25753668_ChIP-Seq_RAJI_Human1.52181677
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51172148
34AR_20517297_ChIP-Seq_VCAP_Human1.49821351
35TAF2_19829295_ChIP-Seq_ESCs_Human1.47740353
36GATA3_27048872_Chip-Seq_THYMUS_Human1.41235828
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.40212587
38TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.39788102
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39540710
40TP53_22573176_ChIP-Seq_HFKS_Human1.38275628
41EWS_26573619_Chip-Seq_HEK293_Human1.37201152
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29228096
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.26864111
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26596873
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.26596873
46ELK1_19687146_ChIP-ChIP_HELA_Human1.25875349
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.25686500
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24664535
49RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23612767
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21238546
51TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.21153464
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.18164064
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14694511
54TAF15_26573619_Chip-Seq_HEK293_Human1.13349257
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11784279
56MYC_19829295_ChIP-Seq_ESCs_Human1.11671055
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08464510
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07683189
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07461794
60FOXP3_21729870_ChIP-Seq_TREG_Human1.07302477
61NANOG_20526341_ChIP-Seq_ESCs_Human1.06331146
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06076146
63GATA1_22025678_ChIP-Seq_K562_Human1.05630438
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04654014
65HOXB7_26014856_ChIP-Seq_BT474_Human1.04547123
66VDR_22108803_ChIP-Seq_LS180_Human1.04361253
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04197166
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03547000
69ERG_20517297_ChIP-Seq_VCAP_Human1.03112045
70BCAT_22108803_ChIP-Seq_LS180_Human1.02987707
71SOX2_19829295_ChIP-Seq_ESCs_Human1.02648990
72NANOG_19829295_ChIP-Seq_ESCs_Human1.02648990
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02454182
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01974074
75BCL6_27268052_Chip-Seq_Bcells_Human1.01222223
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99891279
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99670604
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99194876
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98998360
80ERA_21632823_ChIP-Seq_H3396_Human0.98970818
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97195755
82NCOR_22424771_ChIP-Seq_293T_Human0.93946987
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.93912756
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.93786721
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93045945
86P300_19829295_ChIP-Seq_ESCs_Human0.92055287
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91844183
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90226766
89AR_21572438_ChIP-Seq_LNCaP_Human0.89589570
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89280811
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88725001
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88390976
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87827366
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87259983
95BCOR_27268052_Chip-Seq_Bcells_Human0.86540807
96P300_27268052_Chip-Seq_Bcells_Human0.85541879
97OCT4_20526341_ChIP-Seq_ESCs_Human0.83778815
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82999109
99TCF4_22108803_ChIP-Seq_LS180_Human0.82429253
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.81690345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.25759922
2MP0003011_delayed_dark_adaptation3.42677721
3MP0005671_abnormal_response_to2.84606927
4MP0002166_altered_tumor_susceptibility2.78775030
5MP0003763_abnormal_thymus_physiology2.74614914
6MP0005167_abnormal_blood-brain_barrier2.72950784
7MP0001835_abnormal_antigen_presentation2.71651300
8MP0000013_abnormal_adipose_tissue2.69984045
9MP0008875_abnormal_xenobiotic_pharmacok2.66778687
10MP0002638_abnormal_pupillary_reflex2.63765888
11MP0002102_abnormal_ear_morphology2.56725614
12MP0005646_abnormal_pituitary_gland2.36955242
13MP0005645_abnormal_hypothalamus_physiol2.09653169
14MP0002006_tumorigenesis2.05998303
15MP0002876_abnormal_thyroid_physiology2.01143396
16MP0010030_abnormal_orbit_morphology1.90449922
17MP0009785_altered_susceptibility_to1.83288325
18MP0009333_abnormal_splenocyte_physiolog1.74673718
19MP0002837_dystrophic_cardiac_calcinosis1.72777641
20MP0001968_abnormal_touch/_nociception1.69601648
21MP0008872_abnormal_physiological_respon1.64847311
22MP0008057_abnormal_DNA_replication1.64651148
23MP0002009_preneoplasia1.64187316
24MP0001800_abnormal_humoral_immune1.61222721
25MP0002933_joint_inflammation1.60948114
26MP0000685_abnormal_immune_system1.49079276
27MP0002723_abnormal_immune_serum1.46668574
28MP0003195_calcinosis1.45976969
29MP0000372_irregular_coat_pigmentation1.44897664
30MP0003283_abnormal_digestive_organ1.44587722
31MP0005075_abnormal_melanosome_morpholog1.44369197
32MP0005000_abnormal_immune_tolerance1.43879210
33MP0004885_abnormal_endolymph1.41272406
34MP0003724_increased_susceptibility_to1.40468380
35MP0001986_abnormal_taste_sensitivity1.40276926
36MP0002452_abnormal_antigen_presenting1.39588263
37MP0006276_abnormal_autonomic_nervous1.37874197
38MP0009278_abnormal_bone_marrow1.35747014
39MP0001819_abnormal_immune_cell1.34890147
40MP0002148_abnormal_hypersensitivity_rea1.33937131
41MP0005253_abnormal_eye_physiology1.33394377
42MP0004142_abnormal_muscle_tone1.33159837
43MP0002420_abnormal_adaptive_immunity1.31816999
44MP0005220_abnormal_exocrine_pancreas1.31483363
45MP0003879_abnormal_hair_cell1.28145602
46MP0005387_immune_system_phenotype1.28123660
47MP0001790_abnormal_immune_system1.28123660
48MP0001919_abnormal_reproductive_system1.26845921
49MP0003786_premature_aging1.25904920
50MP0004147_increased_porphyrin_level1.25640071
51MP0004742_abnormal_vestibular_system1.23821177
52MP0004043_abnormal_pH_regulation1.22646491
53MP0003950_abnormal_plasma_membrane1.22515239
54MP0006072_abnormal_retinal_apoptosis1.21909352
55MP0009379_abnormal_foot_pigmentation1.19747041
56MP0001765_abnormal_ion_homeostasis1.13763882
57MP0005389_reproductive_system_phenotype1.12956251
58MP0005025_abnormal_response_to1.07777031
59MP0004381_abnormal_hair_follicle1.07372543
60MP0002405_respiratory_system_inflammati1.06965866
61MP0003436_decreased_susceptibility_to1.05997084
62MP0002736_abnormal_nociception_after1.04641594
63MP0001853_heart_inflammation1.03652073
64MP0000689_abnormal_spleen_morphology1.01832623
65MP0003252_abnormal_bile_duct1.00770768
66MP0001502_abnormal_circadian_rhythm1.00012215
67MP0000703_abnormal_thymus_morphology0.99619480
68MP0000716_abnormal_immune_system0.97328336
69MP0005551_abnormal_eye_electrophysiolog0.96223343
70MP0009764_decreased_sensitivity_to0.94967626
71MP0010329_abnormal_lipoprotein_level0.94936727
72MP0002398_abnormal_bone_marrow0.93737171
73MP0001346_abnormal_lacrimal_gland0.92897171
74MP0002722_abnormal_immune_system0.92135485
75MP0002160_abnormal_reproductive_system0.91882224
76MP0004019_abnormal_vitamin_homeostasis0.91663786
77MP0001879_abnormal_lymphatic_vessel0.90822555
78MP0001845_abnormal_inflammatory_respons0.87066646
79MP0003638_abnormal_response/metabolism_0.86539007
80MP0000613_abnormal_salivary_gland0.83830377
81MP0010155_abnormal_intestine_physiology0.83011402
82MP0009745_abnormal_behavioral_response0.82487162
83MP0008877_abnormal_DNA_methylation0.81180945
84MP0005379_endocrine/exocrine_gland_phen0.81096906
85MP0005410_abnormal_fertilization0.79879829
86MP0002938_white_spotting0.79342875
87MP0002272_abnormal_nervous_system0.78513307
88MP0005636_abnormal_mineral_homeostasis0.78253464
89MP0000647_abnormal_sebaceous_gland0.78158875
90MP0004130_abnormal_muscle_cell0.78101283
91MP0002419_abnormal_innate_immunity0.76252539
92MP0001929_abnormal_gametogenesis0.75411478
93MP0002429_abnormal_blood_cell0.73363837
94MP0008058_abnormal_DNA_repair0.72593917
95MP0005365_abnormal_bile_salt0.68660450
96MP0001984_abnormal_olfaction0.68491082
97MP0005084_abnormal_gallbladder_morpholo0.67761098
98MP0003045_fibrosis0.66839183
99MP0001243_abnormal_dermal_layer0.66728683
100MP0006292_abnormal_olfactory_placode0.65503994

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.83489620
2Abnormality of DNA repair (HP:0003254)4.66525167
3Reduced antithrombin III activity (HP:0001976)4.40032431
4Type I transferrin isoform profile (HP:0003642)4.20886558
5Hypoproteinemia (HP:0003075)3.93771479
6Metabolic alkalosis (HP:0200114)3.93414692
7Elevated erythrocyte sedimentation rate (HP:0003565)3.92936730
8Abnormality of the prostate (HP:0008775)3.91401245
9Congenital stationary night blindness (HP:0007642)3.79345057
10IgG deficiency (HP:0004315)3.61790379
11Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.58359564
12Abnormal protein N-linked glycosylation (HP:0012347)3.58359564
13Abnormal protein glycosylation (HP:0012346)3.58359564
14Abnormal glycosylation (HP:0012345)3.58359564
15Congenital, generalized hypertrichosis (HP:0004540)3.52922111
16Hypokalemic alkalosis (HP:0001949)3.47779940
17Pancreatic cysts (HP:0001737)3.30679936
18Pancreatic fibrosis (HP:0100732)3.28936939
19Abnormality of the pons (HP:0007361)3.20252242
20Entropion (HP:0000621)3.19998028
21Hypoplasia of the pons (HP:0012110)3.16865357
22True hermaphroditism (HP:0010459)3.07939002
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.88869769
24Abnormal rod and cone electroretinograms (HP:0008323)2.80681848
25Large eyes (HP:0001090)2.72829506
26Poikiloderma (HP:0001029)2.71676105
27Attenuation of retinal blood vessels (HP:0007843)2.71386158
28Decreased central vision (HP:0007663)2.69167254
29T lymphocytopenia (HP:0005403)2.68779594
30Abnormality of male internal genitalia (HP:0000022)2.57199945
31Abnormality of the axillary hair (HP:0100134)2.53046957
32Abnormality of secondary sexual hair (HP:0009888)2.53046957
33Severe combined immunodeficiency (HP:0004430)2.52645553
34Bile duct proliferation (HP:0001408)2.49814033
35Abnormal biliary tract physiology (HP:0012439)2.49814033
36Testicular atrophy (HP:0000029)2.46742532
37Type II lissencephaly (HP:0007260)2.42203147
38Abnormality of T cell number (HP:0011839)2.41193863
39Molar tooth sign on MRI (HP:0002419)2.39729215
40Abnormality of midbrain morphology (HP:0002418)2.39729215
41Abolished electroretinogram (ERG) (HP:0000550)2.36631983
42Stomatitis (HP:0010280)2.34764807
43Abnormality of the renal cortex (HP:0011035)2.32326850
44Alkalosis (HP:0001948)2.32163112
45Large for gestational age (HP:0001520)2.28043537
46Arthropathy (HP:0003040)2.26098937
47Dry hair (HP:0011359)2.25906011
48Fatigue (HP:0012378)2.21521317
49Panhypogammaglobulinemia (HP:0003139)2.17203181
50Stomach cancer (HP:0012126)2.16332804
51Pancytopenia (HP:0001876)2.13032573
52Poor head control (HP:0002421)2.12720278
53Keratitis (HP:0000491)2.11387873
54Mitochondrial inheritance (HP:0001427)2.08565630
55Abnormality of the renal medulla (HP:0100957)2.06113340
56Microretrognathia (HP:0000308)2.05391526
57Abnormality of eosinophils (HP:0001879)2.03973367
58Polydipsia (HP:0001959)2.01415435
59Abnormal drinking behavior (HP:0030082)2.01415435
60Decreased subcutaneous fat (HP:0001002)2.01216649
61Thyroiditis (HP:0100646)2.00344694
62Nephronophthisis (HP:0000090)1.99928972
63Abnormality of the renal collecting system (HP:0004742)1.98619390
64Duplicated collecting system (HP:0000081)1.97158439
65Dyschromatopsia (HP:0007641)1.96402200
66Hypotrichosis (HP:0001006)1.93091912
67Methylmalonic acidemia (HP:0002912)1.90602990
68Increased corneal curvature (HP:0100692)1.89623371
69Keratoconus (HP:0000563)1.89623371
70Abnormal mitochondria in muscle tissue (HP:0008316)1.88102540
71Polyuria (HP:0000103)1.87018040
72Azoospermia (HP:0000027)1.86895637
73Optic neuritis (HP:0100653)1.86234908
74Retrobulbar optic neuritis (HP:0100654)1.86234908
75Hepatocellular necrosis (HP:0001404)1.85052903
76Acute necrotizing encephalopathy (HP:0006965)1.84351042
77Pustule (HP:0200039)1.81922668
78Constricted visual fields (HP:0001133)1.81635488
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79887539
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79887539
81Congenital hepatic fibrosis (HP:0002612)1.79421879
82Tubulointerstitial fibrosis (HP:0005576)1.78754690
83Absent/shortened dynein arms (HP:0200106)1.78710786
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.78710786
85Cystic liver disease (HP:0006706)1.78671580
86Absent thumb (HP:0009777)1.78272356
87Combined immunodeficiency (HP:0005387)1.78158741
88Decreased circulating renin level (HP:0003351)1.77789443
89Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77395436
90Ridged nail (HP:0001807)1.77305652
91Abnormality of T cells (HP:0002843)1.76048303
92Increased CSF lactate (HP:0002490)1.74392606
93Eosinophilia (HP:0001880)1.74228887
94Chronic hepatic failure (HP:0100626)1.73512820
95Conical tooth (HP:0000698)1.72055154
96Hypergonadotropic hypogonadism (HP:0000815)1.71682124
97Ulnar claw (HP:0001178)1.70780921
98Macular degeneration (HP:0000608)1.70238693
99Erythroderma (HP:0001019)1.67051384
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65408424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.45162435
2TXK4.02911393
3TAOK33.57545383
4SIK23.08827359
5MAP3K142.94763593
6WNK42.90681193
7FRK2.89476021
8GRK62.81102501
9IKBKB2.78001162
10ZAK2.73975169
11IKBKE2.57424563
12ADRBK22.08046972
13STK391.99869555
14STK241.91660607
15GRK11.88264440
16NUAK11.73861176
17MST41.68411428
18MUSK1.66992096
19MAP4K21.65462634
20CSF1R1.62505038
21WNK31.56847705
22BCKDK1.53541923
23MAP2K21.46497689
24SCYL21.45017113
25PINK11.41606341
26MAP4K11.40792956
27PHKG21.37695580
28PHKG11.37695580
29CLK11.33824586
30KIT1.31010580
31OXSR11.25507644
32SYK1.22317322
33MATK1.14490724
34CAMKK21.02629491
35LYN0.98327258
36ITK0.97965270
37MAP3K130.97759488
38ZAP700.96701446
39BMPR20.92917372
40CHUK0.92846016
41FLT30.92120906
42CDC70.90891781
43JAK30.87749994
44PRKCQ0.85192499
45PIK3CG0.80709084
46STK40.78342440
47PIM10.77845759
48KDR0.76372863
49PIK3CA0.75536206
50LCK0.74710975
51TBK10.74376829
52VRK10.74123323
53RPS6KA50.74040001
54TIE10.67835769
55GRK50.66152485
56BRD40.63930515
57MAPKAPK30.63586651
58TEC0.62508661
59ERBB20.61042211
60MARK30.59422574
61PRKD30.59120993
62BLK0.58770280
63IGF1R0.57955005
64CAMK1D0.56881513
65ADRBK10.56204564
66PRKCE0.55523498
67MAPK70.55057720
68INSRR0.54345160
69ILK0.52771595
70NME10.52289496
71NEK90.51995080
72CSNK1D0.51990380
73PLK20.51726964
74ATR0.50801799
75CAMK10.47480291
76FES0.46230587
77MAPK110.45861290
78PTK2B0.45825134
79ABL10.45201497
80MAP3K40.43934056
81BTK0.43558135
82NTRK10.42242111
83ABL20.40516492
84MAPK40.40383075
85PRKACA0.40027011
86CCNB10.40007320
87SIK30.39245629
88ERBB30.38013172
89AURKA0.37230553
90HCK0.36475272
91TYK20.35601619
92STK30.35488910
93TRPM70.33537912
94AURKB0.33076767
95VRK20.32028258
96PRKCA0.31019374
97EIF2AK30.29010816
98MAPK30.28767337
99ATM0.28203334
100CSNK1G30.26629858

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.01576228
2Asthma_Homo sapiens_hsa053103.40172659
3Nitrogen metabolism_Homo sapiens_hsa009103.38780771
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.30590900
5Graft-versus-host disease_Homo sapiens_hsa053323.20007544
6Allograft rejection_Homo sapiens_hsa053302.97926203
7Autoimmune thyroid disease_Homo sapiens_hsa053202.82501118
8Proteasome_Homo sapiens_hsa030502.38974670
9Type I diabetes mellitus_Homo sapiens_hsa049402.32578757
10Primary immunodeficiency_Homo sapiens_hsa053402.21437499
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09714854
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05306068
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97511557
14RNA polymerase_Homo sapiens_hsa030201.91549990
15Ribosome_Homo sapiens_hsa030101.82786686
16Antigen processing and presentation_Homo sapiens_hsa046121.82296622
17Oxidative phosphorylation_Homo sapiens_hsa001901.80758280
18Rheumatoid arthritis_Homo sapiens_hsa053231.76264087
19Systemic lupus erythematosus_Homo sapiens_hsa053221.69791507
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62759322
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53134789
22Staphylococcus aureus infection_Homo sapiens_hsa051501.41942049
23Linoleic acid metabolism_Homo sapiens_hsa005911.41601978
24Phototransduction_Homo sapiens_hsa047441.33785159
25Hematopoietic cell lineage_Homo sapiens_hsa046401.32161883
26Nucleotide excision repair_Homo sapiens_hsa034201.26759110
27Tryptophan metabolism_Homo sapiens_hsa003801.25198234
28Basal transcription factors_Homo sapiens_hsa030221.25181316
29RNA degradation_Homo sapiens_hsa030181.21552610
30Parkinsons disease_Homo sapiens_hsa050121.19982439
31Viral myocarditis_Homo sapiens_hsa054161.18009419
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.13345249
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12351916
34Homologous recombination_Homo sapiens_hsa034401.12299919
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11016621
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06474906
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99779699
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99341775
39Chemical carcinogenesis_Homo sapiens_hsa052040.98633384
40Peroxisome_Homo sapiens_hsa041460.98191588
41Base excision repair_Homo sapiens_hsa034100.95165190
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90388527
43Retinol metabolism_Homo sapiens_hsa008300.88347761
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87764674
45Protein export_Homo sapiens_hsa030600.86337842
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85360850
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.84904679
48Fanconi anemia pathway_Homo sapiens_hsa034600.82039775
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81738441
50N-Glycan biosynthesis_Homo sapiens_hsa005100.80262343
51Herpes simplex infection_Homo sapiens_hsa051680.78269352
52Leishmaniasis_Homo sapiens_hsa051400.77914967
53Olfactory transduction_Homo sapiens_hsa047400.77316827
54Ether lipid metabolism_Homo sapiens_hsa005650.76586448
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74921375
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74648740
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73740894
58Circadian rhythm_Homo sapiens_hsa047100.72733718
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72628758
60Arachidonic acid metabolism_Homo sapiens_hsa005900.72024876
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71910015
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71439401
63Purine metabolism_Homo sapiens_hsa002300.69107151
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68068345
65Mineral absorption_Homo sapiens_hsa049780.67397686
66Collecting duct acid secretion_Homo sapiens_hsa049660.66675358
67One carbon pool by folate_Homo sapiens_hsa006700.66549970
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.66519423
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66038478
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65215307
71Huntingtons disease_Homo sapiens_hsa050160.63946362
72Regulation of autophagy_Homo sapiens_hsa041400.62197163
73Cardiac muscle contraction_Homo sapiens_hsa042600.60376915
74Morphine addiction_Homo sapiens_hsa050320.58778498
75Epstein-Barr virus infection_Homo sapiens_hsa051690.55596241
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55036130
77Butanoate metabolism_Homo sapiens_hsa006500.53014529
78Pyrimidine metabolism_Homo sapiens_hsa002400.52771267
79Alzheimers disease_Homo sapiens_hsa050100.51615348
80Alcoholism_Homo sapiens_hsa050340.51138536
81Fatty acid biosynthesis_Homo sapiens_hsa000610.50438566
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48584534
83Fatty acid degradation_Homo sapiens_hsa000710.46903527
84ABC transporters_Homo sapiens_hsa020100.45295407
85Vitamin digestion and absorption_Homo sapiens_hsa049770.43427306
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.42895195
87Sulfur metabolism_Homo sapiens_hsa009200.42885494
88Metabolic pathways_Homo sapiens_hsa011000.39991894
89Hedgehog signaling pathway_Homo sapiens_hsa043400.38005785
90Arginine and proline metabolism_Homo sapiens_hsa003300.37210924
91Viral carcinogenesis_Homo sapiens_hsa052030.36808204
92T cell receptor signaling pathway_Homo sapiens_hsa046600.36507000
93Histidine metabolism_Homo sapiens_hsa003400.35562233
94beta-Alanine metabolism_Homo sapiens_hsa004100.35341145
95Serotonergic synapse_Homo sapiens_hsa047260.35018558
96Taste transduction_Homo sapiens_hsa047420.34264595
97Sulfur relay system_Homo sapiens_hsa041220.30906091
98Malaria_Homo sapiens_hsa051440.30680375
99Fat digestion and absorption_Homo sapiens_hsa049750.29230728
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27572490

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