RPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.54307607
2protein retention in ER lumen (GO:0006621)6.46540174
3activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.82354797
4positive regulation of nuclease activity (GO:0032075)5.75675717
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.63051278
6COPII vesicle coating (GO:0048208)5.42259008
7protein maturation by protein folding (GO:0022417)5.40437668
8regulation of nuclease activity (GO:0032069)5.26505968
9folic acid-containing compound biosynthetic process (GO:0009396)5.18825505
10endoplasmic reticulum unfolded protein response (GO:0030968)5.06863877
11cellular response to unfolded protein (GO:0034620)4.91158150
12cellular response to topologically incorrect protein (GO:0035967)4.70668151
13sequestering of metal ion (GO:0051238)4.66569640
14ER-nucleus signaling pathway (GO:0006984)4.62540141
15signal peptide processing (GO:0006465)4.56046144
16vesicle coating (GO:0006901)4.37899941
174-hydroxyproline metabolic process (GO:0019471)4.33229919
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.17863552
19response to endoplasmic reticulum stress (GO:0034976)4.02177487
20* protein N-linked glycosylation via asparagine (GO:0018279)4.00362602
21* peptidyl-asparagine modification (GO:0018196)3.98947648
22exocrine pancreas development (GO:0031017)3.92123872
23pentose-phosphate shunt (GO:0006098)3.85618374
24response to unfolded protein (GO:0006986)3.83096758
25regulation of translational fidelity (GO:0006450)3.71695716
26response to topologically incorrect protein (GO:0035966)3.70152009
27cell adhesion mediated by integrin (GO:0033627)3.69721927
28nuclear pore complex assembly (GO:0051292)3.67411148
29* protein N-linked glycosylation (GO:0006487)3.63490044
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53039238
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53039238
32proline biosynthetic process (GO:0006561)3.52201717
33pteridine-containing compound biosynthetic process (GO:0042559)3.46272490
34UDP-N-acetylglucosamine metabolic process (GO:0006047)3.44496572
35maternal placenta development (GO:0001893)3.42958539
36NADPH regeneration (GO:0006740)3.41557129
37pinocytosis (GO:0006907)3.39830499
38protein autoprocessing (GO:0016540)3.34554886
39protein localization to endosome (GO:0036010)3.34167188
40DNA unwinding involved in DNA replication (GO:0006268)3.30752167
41skin morphogenesis (GO:0043589)3.28298820
42hemidesmosome assembly (GO:0031581)3.26143512
43basement membrane organization (GO:0071711)3.26032112
44* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22935620
45barbed-end actin filament capping (GO:0051016)3.22270402
46peptide catabolic process (GO:0043171)3.16763958
47* protein targeting to ER (GO:0045047)3.15594547
48peptide hormone processing (GO:0016486)3.14923467
49* cotranslational protein targeting to membrane (GO:0006613)3.10759337
50L-alpha-amino acid transmembrane transport (GO:1902475)3.09514676
51nucleobase-containing small molecule interconversion (GO:0015949)3.08453240
52endocrine pancreas development (GO:0031018)3.04115285
53tetrahydrofolate metabolic process (GO:0046653)3.03788731
54* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03309398
55IMP biosynthetic process (GO:0006188)3.00866656
56cell redox homeostasis (GO:0045454)2.97821338
57desmosome organization (GO:0002934)2.96715234
58ER to Golgi vesicle-mediated transport (GO:0006888)2.95813834
59* protein localization to endoplasmic reticulum (GO:0070972)2.94984171
60formation of translation preinitiation complex (GO:0001731)2.94078061
61glucose catabolic process (GO:0006007)2.93875680
62pore complex assembly (GO:0046931)2.91934034
63peptidyl-proline hydroxylation (GO:0019511)2.90980641
64apoptotic cell clearance (GO:0043277)2.88062510
65glycosphingolipid catabolic process (GO:0046479)2.83732083
66glucose 6-phosphate metabolic process (GO:0051156)2.83319097
67hyaluronan catabolic process (GO:0030214)2.82589918
68membrane protein ectodomain proteolysis (GO:0006509)2.79726381
69urea cycle (GO:0000050)2.79031603
70antigen processing and presentation of endogenous antigen (GO:0019883)2.78689101
71regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78588421
72Golgi organization (GO:0007030)2.78251276
73peptidyl-lysine dimethylation (GO:0018027)2.77938315
74mitotic nuclear envelope reassembly (GO:0007084)2.74618370
75nuclear envelope reassembly (GO:0031468)2.74618370
76chaperone-mediated protein folding (GO:0061077)2.72205203
77folic acid metabolic process (GO:0046655)2.71613210
78dosage compensation (GO:0007549)2.71560647
79tricarboxylic acid metabolic process (GO:0072350)2.70833304
80cell-substrate junction assembly (GO:0007044)2.70712810
81proline metabolic process (GO:0006560)2.69865999
82nucleobase biosynthetic process (GO:0046112)2.69300968
83cellular copper ion homeostasis (GO:0006878)2.69046669
84negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67898169
85IMP metabolic process (GO:0046040)2.67787228
86glycolipid catabolic process (GO:0019377)2.65254703
87mitotic nuclear envelope disassembly (GO:0007077)2.62400630
88epithelial cell-cell adhesion (GO:0090136)2.60141084
89urea metabolic process (GO:0019627)2.59668322
90protein hydroxylation (GO:0018126)2.59603502
91glutamine family amino acid biosynthetic process (GO:0009084)2.59598446
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58114604
93DNA strand elongation involved in DNA replication (GO:0006271)2.57756719
94regulation of metalloenzyme activity (GO:0048552)2.56163747
95positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55813421
96mitotic chromosome condensation (GO:0007076)2.55786922
97regulation of translational termination (GO:0006449)2.54722398
98folic acid-containing compound metabolic process (GO:0006760)2.54536162
99regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54251461
100maintenance of protein localization in organelle (GO:0072595)2.53499874
101UMP metabolic process (GO:0046049)2.52610243
102pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.52610243
103UMP biosynthetic process (GO:0006222)2.52610243
104pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.52610243
105embryonic process involved in female pregnancy (GO:0060136)2.52334592
106negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51860487
107alpha-linolenic acid metabolic process (GO:0036109)2.51285619
108nuclear envelope disassembly (GO:0051081)2.50707191
109membrane disassembly (GO:0030397)2.50707191
110spliceosomal tri-snRNP complex assembly (GO:0000244)2.49206146
111regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.47231779
112protein localization to kinetochore (GO:0034501)2.45641114
113nuclear pore organization (GO:0006999)2.45550880
114lipopolysaccharide biosynthetic process (GO:0009103)2.44776542
115pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.42565543
116regulation of cholesterol biosynthetic process (GO:0045540)2.42533874
117ribosomal small subunit assembly (GO:0000028)2.41664785
118glucocorticoid receptor signaling pathway (GO:0042921)2.41420954
119adherens junction assembly (GO:0034333)2.40432311
120regulation of translational elongation (GO:0006448)2.39958654
121cellular response to vitamin D (GO:0071305)2.39807821
122glandular epithelial cell differentiation (GO:0002067)2.39655165
123DNA strand elongation (GO:0022616)2.39215452
124cellular protein complex localization (GO:0034629)2.37394001
125establishment of integrated proviral latency (GO:0075713)2.36214490
126GDP-mannose metabolic process (GO:0019673)2.35587123
127UV protection (GO:0009650)2.35266369
128NADH metabolic process (GO:0006734)2.35193845
129galactose catabolic process (GO:0019388)2.34690992
130focal adhesion assembly (GO:0048041)2.33079218
131cell-substrate adherens junction assembly (GO:0007045)2.33079218
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.32755243
133activation of Rac GTPase activity (GO:0032863)2.32562177
134nitrogen cycle metabolic process (GO:0071941)2.31528776
135positive regulation of endothelial cell apoptotic process (GO:2000353)2.31521110
136regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.30161634
137ER overload response (GO:0006983)2.30131795
138mannose metabolic process (GO:0006013)2.29966597
139amyloid precursor protein catabolic process (GO:0042987)2.29911305
140hormone catabolic process (GO:0042447)2.29828458
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29764575
142endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29046134
143protein folding (GO:0006457)2.28276253
144DNA replication-dependent nucleosome organization (GO:0034723)2.27902398
145DNA replication-dependent nucleosome assembly (GO:0006335)2.27902398
146translesion synthesis (GO:0019985)2.27563380
147branching involved in mammary gland duct morphogenesis (GO:0060444)2.27152431
148chaperone mediated protein folding requiring cofactor (GO:0051085)2.27095819
149nucleotide-sugar biosynthetic process (GO:0009226)2.27074194
150negative regulation of protein localization to plasma membrane (GO:1903077)2.26205375
151endodermal cell differentiation (GO:0035987)2.26045784
152protein complex localization (GO:0031503)2.25297390
153negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.24969620
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.24085584
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22984976
156protein export from nucleus (GO:0006611)2.21379928
157establishment of viral latency (GO:0019043)2.19569914
158COPI coating of Golgi vesicle (GO:0048205)10.3760492
159Golgi transport vesicle coating (GO:0048200)10.3760492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13161105
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32445300
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72424855
4* MYC_18555785_ChIP-Seq_MESCs_Mouse2.98529276
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.88816615
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.35779267
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25089655
8MYC_22102868_ChIP-Seq_BL_Human2.22193234
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18859389
10GATA1_22025678_ChIP-Seq_K562_Human2.09865421
11CLOCK_20551151_ChIP-Seq_293T_Human2.05989889
12MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97414638
13MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93308759
14GABP_17652178_ChIP-ChIP_JURKAT_Human1.91738449
15AR_21909140_ChIP-Seq_LNCAP_Human1.91585366
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90634685
17* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90538212
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87641350
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85765391
20XRN2_22483619_ChIP-Seq_HELA_Human1.80998038
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78647594
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76682352
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73862160
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72999138
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.71278566
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68712289
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67633690
28TFEB_21752829_ChIP-Seq_HELA_Human1.65045147
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62542800
30GABP_19822575_ChIP-Seq_HepG2_Human1.61926474
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61812152
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61661500
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61480666
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61117653
35DCP1A_22483619_ChIP-Seq_HELA_Human1.60744044
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.58929655
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.56823113
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56566802
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.55912469
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55362493
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55279036
42* VDR_21846776_ChIP-Seq_THP-1_Human1.54186294
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54176637
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50423935
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44905962
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42014292
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41710658
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41021523
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39982042
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38503646
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.37927546
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36278576
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36207765
54VDR_23849224_ChIP-Seq_CD4+_Human1.35171551
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.34514110
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.33236612
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32807982
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32502467
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31292003
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30907216
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29825391
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28495052
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27521324
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27409386
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27331436
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26975895
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25827669
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25385291
69FOXP3_21729870_ChIP-Seq_TREG_Human1.25023965
70ATF3_27146783_Chip-Seq_COLON_Human1.24150681
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23657373
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22966824
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22499936
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21248966
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21021954
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21021954
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20589519
78ZNF263_19887448_ChIP-Seq_K562_Human1.19974886
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.19000454
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18219706
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17865131
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17124455
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16050668
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15783107
85CHD1_26751641_Chip-Seq_LNCaP_Human1.15658386
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15559736
87TTF2_22483619_ChIP-Seq_HELA_Human1.14951855
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14826207
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14443022
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11683540
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11588562
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11477816
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11447343
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11208301
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10169602
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09774810
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09435839
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08951889
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08863387
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08133009
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07927472
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07475889
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06381130
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06128406
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04543979
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04269302
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04249042
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03722212
109LXR_22292898_ChIP-Seq_THP-1_Human1.03454376
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02973599
111GATA6_25053715_ChIP-Seq_YYC3_Human1.02917148
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.02870922
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01985549
114ELK1_19687146_ChIP-ChIP_HELA_Human1.01202008
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.00795043
116RACK7_27058665_Chip-Seq_MCF-7_Human1.00793153
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00557828
118* CIITA_25753668_ChIP-Seq_RAJI_Human1.00521527
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00497211
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00397571
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00198358
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98977441
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98430792
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98080290
125* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97668910
126SPI1_23547873_ChIP-Seq_NB4_Human0.97294838
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96790744
128TCF7_22412390_ChIP-Seq_EML_Mouse0.96348488
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96127087
130* UTX_26944678_Chip-Seq_JUKART_Human0.95584669
131* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95154606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.66530067
2MP0006054_spinal_hemorrhage3.59643410
3MP0003283_abnormal_digestive_organ2.80287444
4MP0003693_abnormal_embryo_hatching2.77368639
5MP0008438_abnormal_cutaneous_collagen2.75751967
6MP0003300_gastrointestinal_ulcer2.70538966
7MP0003705_abnormal_hypodermis_morpholog2.59854147
8MP0005451_abnormal_body_composition2.50332243
9MP0005220_abnormal_exocrine_pancreas2.49980866
10MP0010352_gastrointestinal_tract_polyps2.47579338
11MP0004264_abnormal_extraembryonic_tissu2.42547608
12MP0010234_abnormal_vibrissa_follicle2.41075459
13MP0005058_abnormal_lysosome_morphology2.15708660
14MP0003191_abnormal_cellular_cholesterol2.13577170
15MP0008260_abnormal_autophagy2.11030812
16MP0004957_abnormal_blastocyst_morpholog2.09794411
17MP0003566_abnormal_cell_adhesion2.02993405
18MP0001944_abnormal_pancreas_morphology2.02419214
19MP0004233_abnormal_muscle_weight1.97736967
20MP0000013_abnormal_adipose_tissue1.91410168
21MP0002139_abnormal_hepatobiliary_system1.82287726
22MP0002693_abnormal_pancreas_physiology1.81025754
23MP0003183_abnormal_peptide_metabolism1.79415967
24MP0002909_abnormal_adrenal_gland1.75522951
25MP0003172_abnormal_lysosome_physiology1.73726250
26MP0005076_abnormal_cell_differentiation1.72963944
27MP0005623_abnormal_meninges_morphology1.70786591
28MP0002796_impaired_skin_barrier1.63796305
29MP0005501_abnormal_skin_physiology1.55795451
30MP0009780_abnormal_chondrocyte_physiolo1.54184979
31MP0003453_abnormal_keratinocyte_physiol1.53188017
32MP0000537_abnormal_urethra_morphology1.50752612
33MP0004782_abnormal_surfactant_physiolog1.50005743
34MP0003091_abnormal_cell_migration1.49819391
35MP0010307_abnormal_tumor_latency1.49084061
36MP0003941_abnormal_skin_development1.47758139
37MP0009643_abnormal_urine_homeostasis1.46372923
38MP0003123_paternal_imprinting1.44000491
39MP0004858_abnormal_nervous_system1.42983332
40MP0004185_abnormal_adipocyte_glucose1.42497793
41MP0009840_abnormal_foam_cell1.40484740
42MP0005083_abnormal_biliary_tract1.40051255
43MP0005365_abnormal_bile_salt1.39764460
44MP0003195_calcinosis1.38202078
45MP0001666_abnormal_nutrient_absorption1.36074927
46MP0004272_abnormal_basement_membrane1.34574624
47MP0001730_embryonic_growth_arrest1.32746749
48MP0003806_abnormal_nucleotide_metabolis1.32049782
49MP0004043_abnormal_pH_regulation1.31595461
50MP0002896_abnormal_bone_mineralization1.29424155
51MP0001661_extended_life_span1.29391565
52MP0005275_abnormal_skin_tensile1.27576206
53MP0005257_abnormal_intraocular_pressure1.26182862
54MP0003303_peritoneal_inflammation1.24773436
55MP0000678_abnormal_parathyroid_gland1.23987401
56MP0005023_abnormal_wound_healing1.20229884
57MP0001216_abnormal_epidermal_layer1.18178660
58MP0005408_hypopigmentation1.17290893
59MP0000003_abnormal_adipose_tissue1.17018368
60MP0000490_abnormal_crypts_of1.13830817
61MP0003950_abnormal_plasma_membrane1.11631761
62MP0005621_abnormal_cell_physiology1.11545874
63MP0005165_increased_susceptibility_to1.11385853
64MP0001756_abnormal_urination1.05388152
65MP0001849_ear_inflammation1.02745461
66MP0003111_abnormal_nucleus_morphology1.02477993
67MP0005409_darkened_coat_color1.01884346
68MP0003252_abnormal_bile_duct1.01845974
69MP0001243_abnormal_dermal_layer1.01269324
70MP0000358_abnormal_cell_content/1.01000730
71MP0002078_abnormal_glucose_homeostasis0.98074423
72MP0003448_altered_tumor_morphology0.97172890
73MP0000371_diluted_coat_color0.97017000
74MP0002080_prenatal_lethality0.96818674
75MP0003279_aneurysm0.95277193
76MP0003077_abnormal_cell_cycle0.95083961
77MP0003329_amyloid_beta_deposits0.94591489
78MP0010368_abnormal_lymphatic_system0.93836013
79MP0001765_abnormal_ion_homeostasis0.93735143
80MP0002166_altered_tumor_susceptibility0.93030647
81MP0000462_abnormal_digestive_system0.92970344
82MP0009672_abnormal_birth_weight0.92091342
83MP0004197_abnormal_fetal_growth/weight/0.91953277
84MP0000858_altered_metastatic_potential0.91725911
85MP0001881_abnormal_mammary_gland0.90607837
86MP0010094_abnormal_chromosome_stability0.90437879
87MP0001697_abnormal_embryo_size0.89731078
88MP0000465_gastrointestinal_hemorrhage0.89342511
89MP0002928_abnormal_bile_duct0.88060314
90MP0002098_abnormal_vibrissa_morphology0.88055998
91MP0003221_abnormal_cardiomyocyte_apopto0.87853141
92MP0003866_abnormal_defecation0.87647384
93MP0002089_abnormal_postnatal_growth/wei0.87355282
94MP0000604_amyloidosis0.86557560
95MP0010386_abnormal_urinary_bladder0.86037526
96MP0000350_abnormal_cell_proliferation0.85937451
97MP0002086_abnormal_extraembryonic_tissu0.85234624
98MP0004947_skin_inflammation0.84169999
99MP0000598_abnormal_liver_morphology0.84137355
100MP0000627_abnormal_mammary_gland0.83699091
101MP0005360_urolithiasis0.83552243
102MP0000609_abnormal_liver_physiology0.83333927
103MP0010771_integument_phenotype0.83227844
104MP0008007_abnormal_cellular_replicative0.83105217
105MP0000467_abnormal_esophagus_morphology0.82565213
106MP0003075_altered_response_to0.82145798
107MP0005636_abnormal_mineral_homeostasis0.81983091
108MP0000613_abnormal_salivary_gland0.81199999
109MP0009931_abnormal_skin_appearance0.80958568
110MP0009053_abnormal_anal_canal0.80822281
111MP0003795_abnormal_bone_structure0.80725074
112MP0000477_abnormal_intestine_morphology0.80518556
113MP0001958_emphysema0.80177453
114MP0003656_abnormal_erythrocyte_physiolo0.76682696
115MP0002084_abnormal_developmental_patter0.76152363
116MP0009697_abnormal_copulation0.74847451
117MP0000767_abnormal_smooth_muscle0.74339003
118MP0004808_abnormal_hematopoietic_stem0.74209292
119MP0000762_abnormal_tongue_morphology0.73851860
120MP0002060_abnormal_skin_morphology0.73806047
121MP0010329_abnormal_lipoprotein_level0.73639163
122MP0005319_abnormal_enzyme/_coenzyme0.73418800
123MP0009384_cardiac_valve_regurgitation0.73290465
124MP0000747_muscle_weakness0.73234380
125MP0003119_abnormal_digestive_system0.73159632
126MP0002396_abnormal_hematopoietic_system0.72156080
127MP0000377_abnormal_hair_follicle0.71551340
128MP0010678_abnormal_skin_adnexa0.71116133
129MP0003984_embryonic_growth_retardation0.70351344
130MP0008961_abnormal_basal_metabolism0.70179287
131MP0002088_abnormal_embryonic_growth/wei0.70130696
132MP0009333_abnormal_splenocyte_physiolog0.69747037
133MP0005380_embryogenesis_phenotype0.67911508
134MP0001672_abnormal_embryogenesis/_devel0.67911508
135MP0003868_abnormal_feces_composition0.67905723
136MP0000681_abnormal_thyroid_gland0.67884851
137MP0002138_abnormal_hepatobiliary_system0.67881135
138MP0001915_intracranial_hemorrhage0.67351596
139MP0005164_abnormal_response_to0.67132938
140MP0005464_abnormal_platelet_physiology0.66139340
141MP0002019_abnormal_tumor_incidence0.64495348
142MP0005384_cellular_phenotype0.64171004
143MP0001533_abnormal_skeleton_physiology0.63915685
144MP0002135_abnormal_kidney_morphology0.63726623
145MP0008932_abnormal_embryonic_tissue0.63405267
146MP0000428_abnormal_craniofacial_morphol0.63250064

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.53354017
2Vertebral compression fractures (HP:0002953)4.23553348
3Hyperinsulinemic hypoglycemia (HP:0000825)4.15571927
4Hypoglycemic seizures (HP:0002173)4.02759101
5Mucopolysacchariduria (HP:0008155)3.95649097
6Urinary glycosaminoglycan excretion (HP:0003541)3.95649097
7Dysostosis multiplex (HP:0000943)3.67350872
8Abnormality of mucopolysaccharide metabolism (HP:0011020)3.42856943
9Abnormality of polysaccharide metabolism (HP:0011012)3.42856943
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.42856943
11Cervical subluxation (HP:0003308)3.42458882
12Abnormality of the intrinsic pathway (HP:0010989)3.36435189
13Abnormality of endocrine pancreas physiology (HP:0012093)3.32848150
14Abnormality of the pancreatic islet cells (HP:0006476)3.32848150
15Symptomatic seizures (HP:0011145)3.24982435
16Late onset (HP:0003584)3.23438302
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.10208278
18Ketoacidosis (HP:0001993)3.09412485
19Osteolytic defects of the hand bones (HP:0009699)3.04035067
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.04035067
21Cerebral aneurysm (HP:0004944)3.02191605
22Thrombocytosis (HP:0001894)2.92988870
23Thoracolumbar scoliosis (HP:0002944)2.81529434
24Protrusio acetabuli (HP:0003179)2.81371372
25Abnormality of liposaccharide metabolism (HP:0010968)2.81049559
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.81049559
27Abnormality of glycolipid metabolism (HP:0010969)2.81049559
28Pancreatic islet-cell hyperplasia (HP:0004510)2.74463301
29Atrophic scars (HP:0001075)2.68513805
30Vacuolated lymphocytes (HP:0001922)2.68052006
31Short nail (HP:0001799)2.67373765
32Hand muscle atrophy (HP:0009130)2.66001720
33Deep venous thrombosis (HP:0002625)2.63175500
34Flat acetabular roof (HP:0003180)2.62807349
35Achilles tendon contracture (HP:0001771)2.59969221
36Abnormality of the anterior horn cell (HP:0006802)2.58818585
37Degeneration of anterior horn cells (HP:0002398)2.58818585
38Abnormality of the Achilles tendon (HP:0005109)2.50792417
39Hyperglycemia (HP:0003074)2.50590806
40Wormian bones (HP:0002645)2.45325794
41Severe short stature (HP:0003510)2.44566219
42Back pain (HP:0003418)2.43636988
43Insulin resistance (HP:0000855)2.43164773
44Abnormal gallbladder physiology (HP:0012438)2.36574148
45Cholecystitis (HP:0001082)2.36574148
46Abnormality of dentin (HP:0010299)2.35344933
47Premature rupture of membranes (HP:0001788)2.31375475
48Missing ribs (HP:0000921)2.26418169
49Abnormality of the common coagulation pathway (HP:0010990)2.25894370
50Elbow flexion contracture (HP:0002987)2.25740432
51Fragile skin (HP:0001030)2.24177759
5211 pairs of ribs (HP:0000878)2.24070982
53Mitral stenosis (HP:0001718)2.22323509
54Arterial tortuosity (HP:0005116)2.20156068
55Papilledema (HP:0001085)2.19802371
56Generalized aminoaciduria (HP:0002909)2.19757527
57Blue sclerae (HP:0000592)2.19616909
58Asymmetry of the thorax (HP:0001555)2.17404844
59Abnormality of carpal bone ossification (HP:0006257)2.16488686
60Ulnar bowing (HP:0003031)2.15829104
61Abdominal distention (HP:0003270)2.14854961
62Ankle contracture (HP:0006466)2.14633932
63Ketosis (HP:0001946)2.14202437
64Large for gestational age (HP:0001520)2.13179438
65Vascular tortuosity (HP:0004948)2.12719013
66Spastic diplegia (HP:0001264)2.09653493
67Distal lower limb amyotrophy (HP:0008944)2.09592589
68Insulin-resistant diabetes mellitus (HP:0000831)2.09197211
69Abnormality of oral frenula (HP:0000190)2.07569166
70Thin bony cortex (HP:0002753)2.06646593
71Subacute progressive viral hepatitis (HP:0006572)2.06182101
72Biconcave vertebral bodies (HP:0004586)2.06006395
73Beaking of vertebral bodies (HP:0004568)2.05837095
74Abnormal pancreas size (HP:0012094)2.03383671
75Multiple enchondromatosis (HP:0005701)2.02951433
76Abnormal protein glycosylation (HP:0012346)2.02458779
77Abnormal glycosylation (HP:0012345)2.02458779
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02458779
79Abnormal protein N-linked glycosylation (HP:0012347)2.02458779
80Ankyloglossia (HP:0010296)2.00507555
81Aortic dissection (HP:0002647)1.99808326
82Distal lower limb muscle weakness (HP:0009053)1.99160808
83Distal upper limb amyotrophy (HP:0007149)1.97920385
84Upper limb amyotrophy (HP:0009129)1.97920385
85Long toe (HP:0010511)1.97627519
86Abnormality of complement system (HP:0005339)1.97582078
87J-shaped sella turcica (HP:0002680)1.95826061
88Aneurysm (HP:0002617)1.95319514
89Increased connective tissue (HP:0009025)1.94579971
90Insidious onset (HP:0003587)1.93650155
91Termporal pattern (HP:0011008)1.93650155
92Abnormal delivery (HP:0001787)1.90921560
93Tetraparesis (HP:0002273)1.90128538
94Abnormal ossification of hand bones (HP:0005921)1.89632776
95Hypokinesia (HP:0002375)1.89219469
96Right ventricular cardiomyopathy (HP:0011663)1.87315361
97Loss of speech (HP:0002371)1.87260313
98Myocardial infarction (HP:0001658)1.87139876
99Abnormality of the distal phalanges of the toes (HP:0010182)1.86057794
100Interstitial pulmonary disease (HP:0006530)1.85331405
101Breech presentation (HP:0001623)1.84896194
102Spinal rigidity (HP:0003306)1.84793572
103Ragged-red muscle fibers (HP:0003200)1.84730520
104Retinal atrophy (HP:0001105)1.84259815
105Abnormality of the umbilical cord (HP:0010881)1.83729154
106Orthostatic hypotension (HP:0001278)1.83200786
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82096857
108Joint stiffness (HP:0001387)1.81341030
109Dilatation of the ascending aorta (HP:0005111)1.81173763
110Bone pain (HP:0002653)1.80214415
111Cardiovascular calcification (HP:0011915)1.79716482
112Micronodular cirrhosis (HP:0001413)1.79662730
113Increased cerebral lipofuscin (HP:0011813)1.77606195
114Nonimmune hydrops fetalis (HP:0001790)1.77264427
115Insomnia (HP:0100785)1.75947553
116Bowel diverticulosis (HP:0005222)1.75608904
117Hypoplasia of the pons (HP:0012110)1.74994579
118Hyperparathyroidism (HP:0000843)1.74770065
119Generalized amyotrophy (HP:0003700)1.74152117
120Protuberant abdomen (HP:0001538)1.73499529
121Gout (HP:0001997)1.73493388
122Centrally nucleated skeletal muscle fibers (HP:0003687)1.73065587
123Prominent metopic ridge (HP:0005487)1.72582105
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72557787
125Upper motor neuron abnormality (HP:0002127)1.72519535
126Broad face (HP:0000283)1.72045720
127Microglossia (HP:0000171)1.71297209
128Selective tooth agenesis (HP:0001592)1.71052812
129Syringomyelia (HP:0003396)1.70562468
130Spinal cord lesions (HP:0100561)1.70562468
131Rough bone trabeculation (HP:0100670)1.70088675
132Abnormality of the calcaneus (HP:0008364)1.69521484
133Enlarged penis (HP:0000040)1.68855726
134Abnormal cartilage morphology (HP:0002763)1.68086650
135Slender long bone (HP:0003100)1.67656807
136Natal tooth (HP:0000695)1.66835977
137Microretrognathia (HP:0000308)1.66046759
138Progressive muscle weakness (HP:0003323)1.65415504
139Advanced eruption of teeth (HP:0006288)1.64768692
140Thin skin (HP:0000963)1.64459208
141Abnormality of glycolysis (HP:0004366)1.64222556
142Nuclear cataract (HP:0100018)1.63633947
143Vascular calcification (HP:0004934)1.63488349
144Aplastic anemia (HP:0001915)1.63477825
145Intestinal polyposis (HP:0200008)1.63368398
146Bladder diverticulum (HP:0000015)1.63206125
147Coxa vara (HP:0002812)1.62944129
148Platyspondyly (HP:0000926)1.62781426
149Hemorrhage of the eye (HP:0011885)1.62548420
150Metaphyseal cupping (HP:0003021)1.62467751
151Abnormal biliary tract morphology (HP:0012440)1.62380610
152Pathologic fracture (HP:0002756)1.61732724
153Abnormality of the acetabulum (HP:0003170)1.61615761
154Entropion (HP:0000621)1.61398802
155Periodontitis (HP:0000704)1.61123673
156Progressive neurologic deterioration (HP:0002344)1.60169674
157Rectal prolapse (HP:0002035)1.59478455
158Aortic aneurysm (HP:0004942)1.59157554
159Unilateral renal agenesis (HP:0000122)1.58925936
160Abnormality of the thoracic spine (HP:0100711)1.58077850
161Cardiomegaly (HP:0001640)1.57787016
162Angiofibromas (HP:0010615)1.57730910
163Adenoma sebaceum (HP:0009720)1.57730910
164Abnormal foot bone ossification (HP:0010675)1.57541723
165Abnormality of alkaline phosphatase activity (HP:0004379)1.57126653
166Abnormality of subcutaneous fat tissue (HP:0001001)1.56937541
167Exocrine pancreatic insufficiency (HP:0001738)1.56427133
168Hyperacusis (HP:0010780)1.55824553
169Abnormality of calcium-phosphate metabolism (HP:0100530)1.53941795
170Congenital glaucoma (HP:0001087)1.53721074
171Trismus (HP:0000211)1.52850555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.08738281
2TRIB33.96446638
3PASK3.81155162
4SCYL23.68295579
5PKN23.53491518
6SMG12.85709894
7IRAK32.80546751
8EEF2K2.64832862
9TAOK32.29683804
10FLT32.26183320
11TESK12.23258006
12INSRR2.03712500
13PTK61.99014581
14ICK1.94932479
15EIF2AK31.82310513
16PBK1.81382073
17CDK121.71515775
18PDGFRA1.67787643
19BCKDK1.64531701
20LRRK21.64253530
21PAK41.63273487
22LMTK21.62986308
23FRK1.61606137
24EPHA21.59297958
25TESK21.56999891
26BUB11.56876448
27CDC71.55745889
28WEE11.51361797
29MAP3K101.47453864
30NEK21.41974747
31MST1R1.40288011
32PRPF4B1.39904602
33BRSK21.38042731
34MAPK151.26825505
35ARAF1.24752170
36SIK11.24608855
37MET1.24154740
38RPS6KB21.23459174
39LATS21.20918024
40NME21.19373852
41TGFBR11.17423945
42RPS6KA41.11775329
43KDR1.11737110
44MAP3K81.11271840
45SRPK11.09531439
46MAPKAPK31.09487881
47MAP3K21.07941382
48ZAP701.06467407
49TTN1.04952480
50NEK11.04677957
51TAOK21.03633347
52HIPK21.02533636
53EIF2AK11.02501690
54RIPK11.01839375
55PTK20.98176304
56MAP2K20.95245524
57ACVR1B0.92262139
58EPHB10.91776080
59PAK20.91022823
60VRK20.90433834
61ERBB40.89418605
62STK100.85855066
63MAP2K30.84516927
64CDK80.82462585
65FGFR40.82324995
66MAP3K30.81355208
67MAP3K120.79863305
68DYRK1B0.75329206
69PDK20.73881981
70KSR20.73436808
71PIM20.72359248
72FER0.71775700
73MTOR0.71231314
74AURKB0.70380585
75CLK10.65965231
76ABL20.65511800
77TSSK60.64266697
78LATS10.62930384
79MAP3K10.62015364
80MAP4K10.60949930
81BTK0.59881302
82JAK30.59215069
83BRAF0.58689024
84PIK3CG0.58542909
85PRKG20.58290333
86BMX0.58065311
87LIMK10.57941843
88MAPK110.56978067
89CAMKK20.56844519
90CDK70.56685394
91CDK40.55618853
92ATR0.55349186
93MAP3K60.55142143
94RET0.55131480
95ILK0.54832756
96CDK60.53125773
97ALK0.53057659
98MYLK0.52920220
99WNK40.52847611
100MAP3K110.52701685
101VRK10.51598139
102TYK20.51010753
103STK160.50744967
104DYRK30.50561808
105PRKCI0.48594308
106MOS0.47808018
107JAK20.46449107
108AURKA0.46109745
109PAK10.45810073
110DDR20.45734316
111CDK90.44604189
112TTK0.43903170
113PDPK10.43168538
114AKT20.42587343
115RAF10.42066843
116BRSK10.40765412
117MAP3K140.40696890
118NTRK10.39181777
119PLK10.39044620
120TBK10.38518418
121EPHA30.37709162
122DAPK10.37446170
123NEK90.37127766
124CHEK10.36069002
125PDGFRB0.36022917
126MAPKAPK20.35522059
127TLK10.35392876
128MST40.34552828
129ITK0.34118485
130PRKD30.33771512
131CSK0.32433502
132FGFR10.32000579
133RPS6KA20.31427876
134TGFBR20.31207124
135GSK3A0.29528793

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.00512930
2Protein export_Homo sapiens_hsa030604.61478820
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.18291559
4* N-Glycan biosynthesis_Homo sapiens_hsa005102.75405811
5Selenocompound metabolism_Homo sapiens_hsa004502.69654013
6Sulfur metabolism_Homo sapiens_hsa009202.48478245
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33172333
8DNA replication_Homo sapiens_hsa030302.32488207
9One carbon pool by folate_Homo sapiens_hsa006702.15571645
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.11814275
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86380207
12Other glycan degradation_Homo sapiens_hsa005111.80429273
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76176277
14Antigen processing and presentation_Homo sapiens_hsa046121.73669142
15Lysosome_Homo sapiens_hsa041421.67737229
16Galactose metabolism_Homo sapiens_hsa000521.61874938
17Folate biosynthesis_Homo sapiens_hsa007901.59954924
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58648891
19Mismatch repair_Homo sapiens_hsa034301.49970134
20Renin-angiotensin system_Homo sapiens_hsa046141.37796160
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34984432
22Vibrio cholerae infection_Homo sapiens_hsa051101.31338538
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29072913
24RNA transport_Homo sapiens_hsa030131.26040279
25Pentose phosphate pathway_Homo sapiens_hsa000301.22485306
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18494595
27Biosynthesis of amino acids_Homo sapiens_hsa012301.17878242
28Fat digestion and absorption_Homo sapiens_hsa049751.10478156
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07311938
30Fatty acid elongation_Homo sapiens_hsa000621.06667864
31Legionellosis_Homo sapiens_hsa051341.05992884
32Arginine biosynthesis_Homo sapiens_hsa002201.05178012
33Spliceosome_Homo sapiens_hsa030401.05143233
34Bladder cancer_Homo sapiens_hsa052191.03850082
35Carbon metabolism_Homo sapiens_hsa012001.03735995
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03337405
37Phenylalanine metabolism_Homo sapiens_hsa003601.02638122
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98007882
39Ribosome_Homo sapiens_hsa030100.95718966
40Thyroid hormone synthesis_Homo sapiens_hsa049180.92669782
41Sulfur relay system_Homo sapiens_hsa041220.91541502
42Sphingolipid metabolism_Homo sapiens_hsa006000.91040811
43Fatty acid degradation_Homo sapiens_hsa000710.88540910
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88216919
45Tryptophan metabolism_Homo sapiens_hsa003800.88057928
46Steroid biosynthesis_Homo sapiens_hsa001000.87884362
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.86541207
48Cell cycle_Homo sapiens_hsa041100.86477053
49Proteasome_Homo sapiens_hsa030500.85864735
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.85491559
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84850178
52Acute myeloid leukemia_Homo sapiens_hsa052210.83807312
53Base excision repair_Homo sapiens_hsa034100.83723532
54Non-small cell lung cancer_Homo sapiens_hsa052230.82233296
55Viral carcinogenesis_Homo sapiens_hsa052030.82228391
56Protein digestion and absorption_Homo sapiens_hsa049740.81982583
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.81430603
58Salmonella infection_Homo sapiens_hsa051320.81237677
59Starch and sucrose metabolism_Homo sapiens_hsa005000.80410823
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79924389
61Thyroid cancer_Homo sapiens_hsa052160.79068937
62Systemic lupus erythematosus_Homo sapiens_hsa053220.77822680
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77707275
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77150525
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76685181
66Vitamin B6 metabolism_Homo sapiens_hsa007500.76342901
67Nucleotide excision repair_Homo sapiens_hsa034200.75707254
68Fructose and mannose metabolism_Homo sapiens_hsa000510.75414506
69Insulin resistance_Homo sapiens_hsa049310.73742110
70Pyruvate metabolism_Homo sapiens_hsa006200.72880510
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70527645
72Lysine degradation_Homo sapiens_hsa003100.67696222
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.67638019
74Pyrimidine metabolism_Homo sapiens_hsa002400.66971827
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66282561
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65670821
77Hepatitis C_Homo sapiens_hsa051600.65623885
78Endometrial cancer_Homo sapiens_hsa052130.64124385
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62600700
80Glutathione metabolism_Homo sapiens_hsa004800.61444935
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61111996
82Small cell lung cancer_Homo sapiens_hsa052220.60925891
83Fatty acid metabolism_Homo sapiens_hsa012120.57863802
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54902700
85Renal cell carcinoma_Homo sapiens_hsa052110.54879043
86Chronic myeloid leukemia_Homo sapiens_hsa052200.54870966
87Hepatitis B_Homo sapiens_hsa051610.53668921
88Type II diabetes mellitus_Homo sapiens_hsa049300.52899055
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51539773
90Prion diseases_Homo sapiens_hsa050200.51526157
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51124389
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50794871
93p53 signaling pathway_Homo sapiens_hsa041150.50573181
94Focal adhesion_Homo sapiens_hsa045100.48318502
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48019919
96ECM-receptor interaction_Homo sapiens_hsa045120.47288295
97HIF-1 signaling pathway_Homo sapiens_hsa040660.47097311
98MicroRNAs in cancer_Homo sapiens_hsa052060.46564229
99Nitrogen metabolism_Homo sapiens_hsa009100.45055498
100Histidine metabolism_Homo sapiens_hsa003400.44888593
101Endocytosis_Homo sapiens_hsa041440.43741995
102Insulin signaling pathway_Homo sapiens_hsa049100.43064726
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.42270015
104Non-homologous end-joining_Homo sapiens_hsa034500.42126806
105Pancreatic secretion_Homo sapiens_hsa049720.41590246
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41072013
107Glucagon signaling pathway_Homo sapiens_hsa049220.38505856
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38161314
109VEGF signaling pathway_Homo sapiens_hsa043700.37586664
110Arginine and proline metabolism_Homo sapiens_hsa003300.36992758
111Glioma_Homo sapiens_hsa052140.36331962
112Pertussis_Homo sapiens_hsa051330.35952055
113Apoptosis_Homo sapiens_hsa042100.35345455
114mTOR signaling pathway_Homo sapiens_hsa041500.35138634
115ABC transporters_Homo sapiens_hsa020100.35052303
116Alcoholism_Homo sapiens_hsa050340.34011799
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32963717
118Amoebiasis_Homo sapiens_hsa051460.32924059
119Type I diabetes mellitus_Homo sapiens_hsa049400.32590518
120Phagosome_Homo sapiens_hsa041450.30644793
121HTLV-I infection_Homo sapiens_hsa051660.30492400
122Proteoglycans in cancer_Homo sapiens_hsa052050.29722890
123Insulin secretion_Homo sapiens_hsa049110.29318529
124Adherens junction_Homo sapiens_hsa045200.29067769
125Complement and coagulation cascades_Homo sapiens_hsa046100.27724056
126Homologous recombination_Homo sapiens_hsa034400.26559038
127Prostate cancer_Homo sapiens_hsa052150.26306055
128Tyrosine metabolism_Homo sapiens_hsa003500.26060640
129Pancreatic cancer_Homo sapiens_hsa052120.24054861
130AMPK signaling pathway_Homo sapiens_hsa041520.23876793
131Shigellosis_Homo sapiens_hsa051310.23362189

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