RPN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.61889538
2protein retention in ER lumen (GO:0006621)6.67327920
3COPII vesicle coating (GO:0048208)5.90946845
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.73791314
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.55204573
6positive regulation of nuclease activity (GO:0032075)5.48659251
7signal peptide processing (GO:0006465)5.34900330
8regulation of nuclease activity (GO:0032069)5.04552216
9protein maturation by protein folding (GO:0022417)4.99179120
10endoplasmic reticulum unfolded protein response (GO:0030968)4.85488714
11cellular response to unfolded protein (GO:0034620)4.75596583
12cellular response to topologically incorrect protein (GO:0035967)4.58101009
13folic acid-containing compound biosynthetic process (GO:0009396)4.48593566
14ER-nucleus signaling pathway (GO:0006984)4.41201577
15vesicle coating (GO:0006901)4.34266536
16sequestering of metal ion (GO:0051238)4.22702937
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.13574317
184-hydroxyproline metabolic process (GO:0019471)3.96712043
19* protein N-linked glycosylation via asparagine (GO:0018279)3.90802644
20* peptidyl-asparagine modification (GO:0018196)3.89582126
21response to endoplasmic reticulum stress (GO:0034976)3.89142825
22exocrine pancreas development (GO:0031017)3.79013363
23response to unfolded protein (GO:0006986)3.72460262
24establishment of integrated proviral latency (GO:0075713)3.68931619
25nuclear pore complex assembly (GO:0051292)3.65101995
26very-low-density lipoprotein particle assembly (GO:0034379)3.63373685
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60651907
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60651907
29response to topologically incorrect protein (GO:0035966)3.60197230
30* protein N-linked glycosylation (GO:0006487)3.53981290
31peptide hormone processing (GO:0016486)3.49384032
32UDP-N-acetylglucosamine metabolic process (GO:0006047)3.46584678
33protein autoprocessing (GO:0016540)3.33521368
34endocrine pancreas development (GO:0031018)3.31455951
35plasma lipoprotein particle assembly (GO:0034377)3.30462453
36peptide catabolic process (GO:0043171)3.27154193
37peptidyl-proline hydroxylation (GO:0019511)3.22252084
38proline biosynthetic process (GO:0006561)3.20528147
39nuclear pore organization (GO:0006999)3.15630382
40proline metabolic process (GO:0006560)3.14022652
41ER to Golgi vesicle-mediated transport (GO:0006888)3.13523502
42mitotic chromosome condensation (GO:0007076)3.11528070
43* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10726132
44L-serine metabolic process (GO:0006563)3.10275032
45keratan sulfate catabolic process (GO:0042340)3.10173137
46negative regulation of glycoprotein biosynthetic process (GO:0010561)3.10156888
47pteridine-containing compound biosynthetic process (GO:0042559)3.05967797
48tRNA aminoacylation for protein translation (GO:0006418)3.05460218
49IMP biosynthetic process (GO:0006188)3.05173432
50establishment of viral latency (GO:0019043)3.05168738
51glandular epithelial cell differentiation (GO:0002067)3.02874288
52* protein targeting to ER (GO:0045047)3.02658574
53regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.01764015
54* cotranslational protein targeting to membrane (GO:0006613)2.99013725
55ribosome assembly (GO:0042255)2.98810246
56cell redox homeostasis (GO:0045454)2.95340988
57type B pancreatic cell development (GO:0003323)2.94814540
58formation of translation preinitiation complex (GO:0001731)2.93050904
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91171858
60amino acid activation (GO:0043038)2.89145282
61tRNA aminoacylation (GO:0043039)2.89145282
62* establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88843893
63L-alpha-amino acid transmembrane transport (GO:1902475)2.86982849
64apoptotic cell clearance (GO:0043277)2.86112830
65antigen processing and presentation of endogenous antigen (GO:0019883)2.86063492
66* protein localization to endoplasmic reticulum (GO:0070972)2.84162002
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83841526
68protein-lipid complex assembly (GO:0065005)2.83445056
69negative regulation of fibrinolysis (GO:0051918)2.82443889
70GDP-mannose metabolic process (GO:0019673)2.82436875
71protein hydroxylation (GO:0018126)2.81085060
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80644150
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77715855
74regulation of cholesterol esterification (GO:0010872)2.75195782
75nucleobase-containing small molecule interconversion (GO:0015949)2.74791225
76ER overload response (GO:0006983)2.74524448
77cellular response to vitamin D (GO:0071305)2.74025747
78chaperone-mediated protein folding (GO:0061077)2.72922423
79pore complex assembly (GO:0046931)2.72890339
80nucleobase biosynthetic process (GO:0046112)2.71904392
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71537626
82negative regulation of ligase activity (GO:0051352)2.71537626
83mitotic sister chromatid segregation (GO:0000070)2.69606715
84tetrahydrofolate metabolic process (GO:0046653)2.69367981
85pentose-phosphate shunt (GO:0006098)2.68520965
86maintenance of protein localization in organelle (GO:0072595)2.68193564
87regulation of cholesterol biosynthetic process (GO:0045540)2.65376891
88regulation of cellular amino acid metabolic process (GO:0006521)2.64050418
89nucleotide-sugar biosynthetic process (GO:0009226)2.63717488
90tricarboxylic acid cycle (GO:0006099)2.63661564
91peptidyl-glutamic acid carboxylation (GO:0017187)2.63198878
92protein carboxylation (GO:0018214)2.63198878
93mannose metabolic process (GO:0006013)2.62751817
94glandular epithelial cell development (GO:0002068)2.60874651
95maternal placenta development (GO:0001893)2.60793195
96cell adhesion mediated by integrin (GO:0033627)2.60102135
97regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59482222
98regulation of translational fidelity (GO:0006450)2.58935257
99DNA strand elongation involved in DNA replication (GO:0006271)2.58931014
100pinocytosis (GO:0006907)2.58211818
101ribosomal small subunit assembly (GO:0000028)2.57880048
102folic acid metabolic process (GO:0046655)2.57094496
103serine family amino acid biosynthetic process (GO:0009070)2.56634580
104basement membrane organization (GO:0071711)2.55348887
105telomere maintenance via recombination (GO:0000722)2.54893593
106regulation of mitochondrial translation (GO:0070129)2.54311472
107glutamine family amino acid biosynthetic process (GO:0009084)2.54035011
108DNA unwinding involved in DNA replication (GO:0006268)2.53602772
109regulation of mitotic spindle organization (GO:0060236)2.53568814
110proteasome assembly (GO:0043248)2.53397245
111regulation of sister chromatid cohesion (GO:0007063)2.50704898
112IMP metabolic process (GO:0046040)2.49659624
113mitotic recombination (GO:0006312)2.47708608
114Golgi organization (GO:0007030)2.47482326
115double-strand break repair via nonhomologous end joining (GO:0006303)2.45956525
116non-recombinational repair (GO:0000726)2.45956525
117sister chromatid segregation (GO:0000819)2.45919938
118negative regulation of glycoprotein metabolic process (GO:1903019)2.45661501
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.44980402
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.44980402
121regulation of type B pancreatic cell apoptotic process (GO:2000674)2.44445860
122chaperone mediated protein folding requiring cofactor (GO:0051085)2.43516227
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.43076611
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.43076611
125DNA ligation (GO:0006266)2.42445122
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42146399
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42146399
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42146399
129biotin metabolic process (GO:0006768)2.41598148
130cholesterol biosynthetic process (GO:0006695)2.41332829
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40924263
132DNA strand elongation (GO:0022616)2.40198240
133mitotic nuclear envelope disassembly (GO:0007077)2.37943551
134DNA replication initiation (GO:0006270)2.37779189
135mitotic metaphase plate congression (GO:0007080)2.37609786
136tricarboxylic acid metabolic process (GO:0072350)2.37281803
137folic acid-containing compound metabolic process (GO:0006760)2.36837247
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.36622570
139translesion synthesis (GO:0019985)2.35874561
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.35329080
141columnar/cuboidal epithelial cell development (GO:0002066)2.35036307
142regulation of fibrinolysis (GO:0051917)2.34926467
143NADPH regeneration (GO:0006740)2.33809513
144nucleotide-sugar metabolic process (GO:0009225)2.32311211
145protein folding (GO:0006457)2.31939814
146regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.31606766
147cellular response to vitamin (GO:0071295)2.30612131
148telomere maintenance via semi-conservative replication (GO:0032201)2.29568769
149glucose catabolic process (GO:0006007)2.28465386
150galactose catabolic process (GO:0019388)2.27668132
151antigen processing and presentation via MHC class Ib (GO:0002475)2.27345992
152intestinal epithelial cell development (GO:0060576)2.25842244
153DNA deamination (GO:0045006)2.24173428
154valine metabolic process (GO:0006573)2.23178630
155membrane disassembly (GO:0030397)2.23028885
156nuclear envelope disassembly (GO:0051081)2.23028885
157purine nucleobase biosynthetic process (GO:0009113)2.22701459
158antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.22133839
159Golgi transport vesicle coating (GO:0048200)10.6123927
160COPI coating of Golgi vesicle (GO:0048205)10.6123927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20055859
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50310158
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99269539
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.92636779
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.51058979
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38189285
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.31729799
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.20691748
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18607053
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14763475
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13479985
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06637120
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98643405
14CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96738292
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.95524036
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.93289581
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91759050
18AR_21909140_ChIP-Seq_LNCAP_Human1.89701660
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89024762
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88736287
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88254085
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88101935
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81408599
24GATA1_22025678_ChIP-Seq_K562_Human1.79967832
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77530046
26MYC_22102868_ChIP-Seq_BL_Human1.77189785
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76691769
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76543173
29TFEB_21752829_ChIP-Seq_HELA_Human1.75977392
30* CLOCK_20551151_ChIP-Seq_293T_Human1.75884965
31XRN2_22483619_ChIP-Seq_HELA_Human1.74423704
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.73876529
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73611749
34DCP1A_22483619_ChIP-Seq_HELA_Human1.72818052
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.70499662
36* GABP_19822575_ChIP-Seq_HepG2_Human1.69923992
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69745575
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68682271
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66765756
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61691653
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61460806
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60203572
43VDR_23849224_ChIP-Seq_CD4+_Human1.52194822
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50649737
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48184800
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.45760267
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41031404
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40895105
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.40704494
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38749960
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38732930
52KDM5A_27292631_Chip-Seq_BREAST_Human1.38695311
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37113136
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37091417
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36404379
56* FOXP3_21729870_ChIP-Seq_TREG_Human1.36344547
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34329650
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34228737
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33445800
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32371654
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29420315
62CIITA_25753668_ChIP-Seq_RAJI_Human1.29100176
63ELK1_19687146_ChIP-ChIP_HELA_Human1.28804493
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27893217
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27114099
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26673093
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26352336
68VDR_21846776_ChIP-Seq_THP-1_Human1.26281246
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.26224158
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25420580
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25418327
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23895794
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23155376
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23106120
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21078289
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20070318
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19214194
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19120843
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.18062461
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16436999
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16378182
82* TTF2_22483619_ChIP-Seq_HELA_Human1.16310441
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16302116
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15727582
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14292938
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13213164
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11864410
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11364574
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11207138
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10935483
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10784893
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10287788
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09896312
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09258192
95ATF3_27146783_Chip-Seq_COLON_Human1.08049922
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08049668
97ZNF263_19887448_ChIP-Seq_K562_Human1.07826790
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07508149
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05976947
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04930147
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04919854
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04758616
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03922661
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03698556
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02584645
106CHD1_26751641_Chip-Seq_LNCaP_Human1.02583742
107RXR_22158963_ChIP-Seq_LIVER_Mouse1.02297473
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02006362
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01245915
110SPI1_23547873_ChIP-Seq_NB4_Human1.00655923
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00446814
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.00095729
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.00013045
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99886763
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99783789
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99667432
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.98479159
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97994731
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96787397
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96316339
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95709649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.56299196
2MP0003283_abnormal_digestive_organ3.46627191
3MP0008438_abnormal_cutaneous_collagen3.30220804
4MP0006054_spinal_hemorrhage3.18663232
5MP0005220_abnormal_exocrine_pancreas2.47830203
6MP0003693_abnormal_embryo_hatching2.42306266
7MP0005058_abnormal_lysosome_morphology2.37592302
8MP0003941_abnormal_skin_development2.36012638
9MP0003300_gastrointestinal_ulcer2.35512856
10MP0010352_gastrointestinal_tract_polyps2.21566233
11MP0001944_abnormal_pancreas_morphology2.14542815
12MP0010030_abnormal_orbit_morphology2.08034994
13MP0004264_abnormal_extraembryonic_tissu2.07314968
14MP0003705_abnormal_hypodermis_morpholog2.06055528
15MP0002693_abnormal_pancreas_physiology1.95489746
16MP0000013_abnormal_adipose_tissue1.92529703
17MP0003195_calcinosis1.89766923
18MP0002909_abnormal_adrenal_gland1.80440169
19MP0004957_abnormal_blastocyst_morpholog1.77336986
20MP0003122_maternal_imprinting1.75940680
21MP0005360_urolithiasis1.73599173
22MP0000678_abnormal_parathyroid_gland1.71404821
23MP0005451_abnormal_body_composition1.62027760
24MP0003566_abnormal_cell_adhesion1.61823027
25MP0004233_abnormal_muscle_weight1.59449164
26MP0009697_abnormal_copulation1.56504000
27MP0005275_abnormal_skin_tensile1.54721090
28MP0003183_abnormal_peptide_metabolism1.54130333
29MP0005076_abnormal_cell_differentiation1.51004790
30MP0004043_abnormal_pH_regulation1.46603203
31MP0010386_abnormal_urinary_bladder1.46209516
32MP0008058_abnormal_DNA_repair1.45654978
33MP0003315_abnormal_perineum_morphology1.43905248
34MP0002896_abnormal_bone_mineralization1.41833612
35MP0003191_abnormal_cellular_cholesterol1.39058386
36MP0008260_abnormal_autophagy1.38356086
37MP0003172_abnormal_lysosome_physiology1.36079480
38MP0009643_abnormal_urine_homeostasis1.35498416
39MP0010234_abnormal_vibrissa_follicle1.33626662
40MP0001661_extended_life_span1.32117349
41MP0001915_intracranial_hemorrhage1.30581024
42MP0009780_abnormal_chondrocyte_physiolo1.29988567
43MP0005380_embryogenesis_phenotype1.25870625
44MP0001672_abnormal_embryogenesis/_devel1.25870625
45MP0001849_ear_inflammation1.25753409
46MP0000566_synostosis1.25645639
47MP0004272_abnormal_basement_membrane1.25416751
48MP0003950_abnormal_plasma_membrane1.25297371
49MP0010307_abnormal_tumor_latency1.25004505
50MP0008007_abnormal_cellular_replicative1.24980472
51MP0002139_abnormal_hepatobiliary_system1.24458706
52MP0005023_abnormal_wound_healing1.21354507
53MP0005503_abnormal_tendon_morphology1.18567655
54MP0001666_abnormal_nutrient_absorption1.17101906
55MP0003718_maternal_effect1.16815008
56MP0000490_abnormal_crypts_of1.13489387
57MP0002938_white_spotting1.11626579
58MP0004858_abnormal_nervous_system1.10059882
59MP0001756_abnormal_urination1.09893238
60MP0009840_abnormal_foam_cell1.09657774
61MP0005501_abnormal_skin_physiology1.09650783
62MP0000462_abnormal_digestive_system1.06828190
63MP0008875_abnormal_xenobiotic_pharmacok1.06746131
64MP0000003_abnormal_adipose_tissue1.06509863
65MP0003111_abnormal_nucleus_morphology1.05974402
66MP0002089_abnormal_postnatal_growth/wei1.05440041
67MP0001730_embryonic_growth_arrest1.04511912
68MP0009384_cardiac_valve_regurgitation1.04187641
69MP0000627_abnormal_mammary_gland1.02590900
70MP0001881_abnormal_mammary_gland1.01892656
71MP0005197_abnormal_uvea_morphology1.01606688
72MP0000613_abnormal_salivary_gland1.01537056
73MP0004782_abnormal_surfactant_physiolog1.00517690
74MP0002697_abnormal_eye_size1.00465935
75MP0005171_absent_coat_pigmentation0.99533884
76MP0003077_abnormal_cell_cycle0.98599462
77MP0003795_abnormal_bone_structure0.97215005
78MP0002085_abnormal_embryonic_tissue0.96817495
79MP0002078_abnormal_glucose_homeostasis0.96353600
80MP0005365_abnormal_bile_salt0.96059469
81MP0002084_abnormal_developmental_patter0.95695527
82MP0003123_paternal_imprinting0.92978866
83MP0003942_abnormal_urinary_system0.92729373
84MP0002060_abnormal_skin_morphology0.91888947
85MP0002796_impaired_skin_barrier0.91515148
86MP0000762_abnormal_tongue_morphology0.91446349
87MP0001533_abnormal_skeleton_physiology0.90512523
88MP0000537_abnormal_urethra_morphology0.89765767
89MP0005257_abnormal_intraocular_pressure0.89383773
90MP0000858_altered_metastatic_potential0.88776091
91MP0001958_emphysema0.88173029
92MP0003385_abnormal_body_wall0.87744310
93MP0001346_abnormal_lacrimal_gland0.87721806
94MP0001243_abnormal_dermal_layer0.87560018
95MP0003806_abnormal_nucleotide_metabolis0.87416594
96MP0002396_abnormal_hematopoietic_system0.86710732
97MP0001216_abnormal_epidermal_layer0.86124802
98MP0010094_abnormal_chromosome_stability0.85509924
99MP0003866_abnormal_defecation0.85420669
100MP0002098_abnormal_vibrissa_morphology0.84660640
101MP0010329_abnormal_lipoprotein_level0.84165846
102MP0002933_joint_inflammation0.83926386
103MP0005083_abnormal_biliary_tract0.83854303
104MP0005379_endocrine/exocrine_gland_phen0.83813733
105MP0003252_abnormal_bile_duct0.83774553
106MP0004197_abnormal_fetal_growth/weight/0.83699949
107MP0005623_abnormal_meninges_morphology0.83422433
108MP0000358_abnormal_cell_content/0.82871168
109MP0005384_cellular_phenotype0.82296015
110MP0002080_prenatal_lethality0.80999152
111MP0002928_abnormal_bile_duct0.79877942
112MP0000598_abnormal_liver_morphology0.79870554
113MP0003279_aneurysm0.79349216
114MP0004808_abnormal_hematopoietic_stem0.79319078
115MP0009672_abnormal_birth_weight0.79277690
116MP0003786_premature_aging0.79053307
117MP0010368_abnormal_lymphatic_system0.78582037
118MP0002092_abnormal_eye_morphology0.78145677
119MP0003115_abnormal_respiratory_system0.77632201
120MP0001765_abnormal_ion_homeostasis0.77495618
121MP0003937_abnormal_limbs/digits/tail_de0.76890183
122MP0002166_altered_tumor_susceptibility0.76476923
123MP0000681_abnormal_thyroid_gland0.75232814
124MP0000467_abnormal_esophagus_morphology0.74874230
125MP0008932_abnormal_embryonic_tissue0.74636962
126MP0005621_abnormal_cell_physiology0.74151224
127MP0009333_abnormal_splenocyte_physiolog0.73963355
128MP0005636_abnormal_mineral_homeostasis0.73895502
129MP0001697_abnormal_embryo_size0.73660876
130MP0002295_abnormal_pulmonary_circulatio0.73548230
131MP0002233_abnormal_nose_morphology0.73418522
132MP0002234_abnormal_pharynx_morphology0.73329269
133MP0000350_abnormal_cell_proliferation0.72925269
134MP0000477_abnormal_intestine_morphology0.72314134
135MP0005165_increased_susceptibility_to0.72267199
136MP0005508_abnormal_skeleton_morphology0.72216789
137MP0005408_hypopigmentation0.71456897
138MP0000163_abnormal_cartilage_morphology0.71240361
139MP0002111_abnormal_tail_morphology0.70319756
140MP0000609_abnormal_liver_physiology0.70277836
141MP0000465_gastrointestinal_hemorrhage0.70249146
142MP0000428_abnormal_craniofacial_morphol0.68798000
143MP0001270_distended_abdomen0.68680345
144MP0002086_abnormal_extraembryonic_tissu0.68023621
145MP0005390_skeleton_phenotype0.67806399
146MP0003186_abnormal_redox_activity0.67514607
147MP0001919_abnormal_reproductive_system0.66787928
148MP0003984_embryonic_growth_retardation0.66495958
149MP0002135_abnormal_kidney_morphology0.66245657
150MP0002088_abnormal_embryonic_growth/wei0.65544909
151MP0003436_decreased_susceptibility_to0.65448994
152MP0003868_abnormal_feces_composition0.64188498

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.37291009
2Deep venous thrombosis (HP:0002625)4.26156193
3Hyperinsulinemic hypoglycemia (HP:0000825)4.14384401
4Hypoglycemic seizures (HP:0002173)3.98148727
5Cervical subluxation (HP:0003308)3.87119459
6Mucopolysacchariduria (HP:0008155)3.81382038
7Urinary glycosaminoglycan excretion (HP:0003541)3.81382038
8Abnormality of glycolysis (HP:0004366)3.78195198
9Dysostosis multiplex (HP:0000943)3.70231001
10Increased serum pyruvate (HP:0003542)3.46194408
11Protrusio acetabuli (HP:0003179)3.34811253
12Abnormality of polysaccharide metabolism (HP:0011012)3.33318888
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33318888
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33318888
15Vacuolated lymphocytes (HP:0001922)3.32610570
16Symptomatic seizures (HP:0011145)3.24683766
17Hypobetalipoproteinemia (HP:0003563)3.20268890
1811 pairs of ribs (HP:0000878)3.14771555
19Beaking of vertebral bodies (HP:0004568)3.13873031
20Premature rupture of membranes (HP:0001788)3.08675152
21Abnormality of the intrinsic pathway (HP:0010989)3.06763199
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.01083520
23Abnormal gallbladder physiology (HP:0012438)3.00568696
24Cholecystitis (HP:0001082)3.00568696
25Abnormality of carpal bone ossification (HP:0006257)2.98608033
26Abnormality of the pancreatic islet cells (HP:0006476)2.92577714
27Abnormality of endocrine pancreas physiology (HP:0012093)2.92577714
28Late onset (HP:0003584)2.85729075
29Thoracolumbar scoliosis (HP:0002944)2.84163680
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.81375153
31Small epiphyses (HP:0010585)2.70328292
32Missing ribs (HP:0000921)2.70118208
33Microvesicular hepatic steatosis (HP:0001414)2.67595528
34Abnormality of the anterior horn cell (HP:0006802)2.63151443
35Degeneration of anterior horn cells (HP:0002398)2.63151443
36Cerebral aneurysm (HP:0004944)2.62383480
37Hyperglycemia (HP:0003074)2.59666808
38Thrombocytosis (HP:0001894)2.57225589
39Insulin-resistant diabetes mellitus (HP:0000831)2.55527524
40Metaphyseal cupping (HP:0003021)2.52681571
41Abnormality of dentin (HP:0010299)2.52573299
42Pancreatic islet-cell hyperplasia (HP:0004510)2.52043275
43Prolonged partial thromboplastin time (HP:0003645)2.50376818
44Severe short stature (HP:0003510)2.47725498
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47452068
46Abnormal protein glycosylation (HP:0012346)2.44107182
47Abnormal glycosylation (HP:0012345)2.44107182
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44107182
49Abnormal protein N-linked glycosylation (HP:0012347)2.44107182
50Insulin resistance (HP:0000855)2.43946120
51Abnormal pancreas size (HP:0012094)2.43485386
52Abnormal delivery (HP:0001787)2.43406957
53Short nail (HP:0001799)2.41828264
54Large for gestational age (HP:0001520)2.41241771
55Ketoacidosis (HP:0001993)2.40991445
56Hand muscle atrophy (HP:0009130)2.38689702
57Hypolipoproteinemia (HP:0010981)2.38526353
58Chromsome breakage (HP:0040012)2.36180227
59Asymmetry of the thorax (HP:0001555)2.36059835
60Platyspondyly (HP:0000926)2.30948894
61Abnormality of the calcaneus (HP:0008364)2.28947514
62Nonimmune hydrops fetalis (HP:0001790)2.28154025
63Joint stiffness (HP:0001387)2.27863924
64Ankle contracture (HP:0006466)2.27323906
65Increased cerebral lipofuscin (HP:0011813)2.26494583
66Absent epiphyses (HP:0010577)2.24413189
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24413189
68Abnormality of the common coagulation pathway (HP:0010990)2.24216621
69Abnormal foot bone ossification (HP:0010675)2.20903311
70Deviation of the thumb (HP:0009603)2.19818733
71Abnormal ossification of hand bones (HP:0005921)2.19432195
72Type I transferrin isoform profile (HP:0003642)2.17052978
73Microglossia (HP:0000171)2.16901604
74Overlapping toe (HP:0001845)2.16688775
75Renal duplication (HP:0000075)2.15625902
76Abnormality of the acetabulum (HP:0003170)2.15438278
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.12466003
78Generalized aminoaciduria (HP:0002909)2.11465065
79Trismus (HP:0000211)2.10034229
80Abdominal distention (HP:0003270)2.09170953
81Increased nuchal translucency (HP:0010880)2.06991641
82Abnormality of methionine metabolism (HP:0010901)2.05746602
83Pterygium (HP:0001059)2.05137425
84Proximal placement of thumb (HP:0009623)2.01469575
85Hypercholesterolemia (HP:0003124)1.99210676
86Protuberant abdomen (HP:0001538)1.98414096
87Unilateral renal agenesis (HP:0000122)1.97596775
88Abnormal cartilage morphology (HP:0002763)1.97478184
89Prominent metopic ridge (HP:0005487)1.95936397
90Soft skin (HP:0000977)1.95164705
91Abnormal hand bone ossification (HP:0010660)1.95092273
92Abnormality of glycosphingolipid metabolism (HP:0004343)1.91060799
93Abnormality of glycolipid metabolism (HP:0010969)1.91060799
94Abnormality of liposaccharide metabolism (HP:0010968)1.91060799
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.90826685
96Vertebral hypoplasia (HP:0008417)1.90826685
97Vascular calcification (HP:0004934)1.89952889
98Hypoplasia of the odontoid process (HP:0003311)1.89776064
99Multiple enchondromatosis (HP:0005701)1.89478775
100Ovoid vertebral bodies (HP:0003300)1.89282843
101Reduced antithrombin III activity (HP:0001976)1.89213334
102Broad face (HP:0000283)1.87902791
103Disproportionate short-trunk short stature (HP:0003521)1.87121593
104Epiphyseal dysplasia (HP:0002656)1.86894895
105Aortic dissection (HP:0002647)1.86596732
106Entropion (HP:0000621)1.85707102
107Abnormality of the umbilical cord (HP:0010881)1.85248599
108Spastic paraparesis (HP:0002313)1.84382908
109Hyperparathyroidism (HP:0000843)1.83941768
110Cardiovascular calcification (HP:0011915)1.83708467
111Progressive muscle weakness (HP:0003323)1.83668424
112Abnormality of the distal phalanges of the toes (HP:0010182)1.83388125
113Abnormality of the Achilles tendon (HP:0005109)1.83134878
114Intrahepatic cholestasis (HP:0001406)1.83093275
115Ulnar deviation of the wrist (HP:0003049)1.82999407
116Poor head control (HP:0002421)1.82431584
117Gout (HP:0001997)1.81162269
118Vertebral compression fractures (HP:0002953)1.80719114
119Progressive neurologic deterioration (HP:0002344)1.80461202
120Right ventricular cardiomyopathy (HP:0011663)1.80381597
121Secondary amenorrhea (HP:0000869)1.79742337
122Spondylolisthesis (HP:0003302)1.79014071
123Hypokinesia (HP:0002375)1.78212975
124Aneurysm (HP:0002617)1.78045186
125Spinal cord compression (HP:0002176)1.77647226
126Septate vagina (HP:0001153)1.77102504
127Abnormal tarsal ossification (HP:0008369)1.76439113
128Aortic aneurysm (HP:0004942)1.75828679
129Abnormality of subcutaneous fat tissue (HP:0001001)1.75748559
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75720132
131Sparse eyelashes (HP:0000653)1.75304519
132Blue sclerae (HP:0000592)1.74437557
133Hyperammonemia (HP:0001987)1.74138520
134Villous atrophy (HP:0011473)1.73845023
135Abnormality of small intestinal villus morphology (HP:0011472)1.73845023
136Elbow flexion contracture (HP:0002987)1.73775736
137Flat acetabular roof (HP:0003180)1.73053771
138Breech presentation (HP:0001623)1.73030120
139Abnormalities of placenta or umbilical cord (HP:0001194)1.71782438
140Abnormality of calcium-phosphate metabolism (HP:0100530)1.71689219
141Irregular vertebral endplates (HP:0003301)1.71171906
142Coxa valga (HP:0002673)1.70717555
143Long toe (HP:0010511)1.70025783
144Meckel diverticulum (HP:0002245)1.69488098
145Rough bone trabeculation (HP:0100670)1.69256879
146Broad palm (HP:0001169)1.67850389
147Back pain (HP:0003418)1.67718555
148Selective tooth agenesis (HP:0001592)1.66813031
149Abnormality of the odontoid process (HP:0003310)1.66561829
150Abnormal biliary tract morphology (HP:0012440)1.66457278
151Rhizomelia (HP:0008905)1.64872642
152Xanthomatosis (HP:0000991)1.64704212
153Hypoplasia of the pons (HP:0012110)1.64633271
154Hypoalphalipoproteinemia (HP:0003233)1.64075655
155Orthostatic hypotension (HP:0001278)1.64029561
156Spastic diplegia (HP:0001264)1.63963354
157Aplastic anemia (HP:0001915)1.63961515
158Hyperacusis (HP:0010780)1.63857954
159Dilatation of the ascending aorta (HP:0005111)1.63691259
160Distal upper limb amyotrophy (HP:0007149)1.63548807
161Upper limb amyotrophy (HP:0009129)1.63548807
162Facial cleft (HP:0002006)1.60725710
163Deep philtrum (HP:0002002)1.60042012
164Achilles tendon contracture (HP:0001771)1.60005435
165Broad alveolar ridges (HP:0000187)1.59884696
166Ulnar bowing (HP:0003031)1.59735604
167Cupped ribs (HP:0000887)1.59036862
168Natal tooth (HP:0000695)1.58613127
169Coxa vara (HP:0002812)1.58426056
170Limited elbow extension (HP:0001377)1.58046273
171Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58040524
172Abnormality of monocarboxylic acid metabolism (HP:0010996)1.56655346
173Abnormality of pain sensation (HP:0010832)1.56513876
174Impaired pain sensation (HP:0007328)1.56513876
175Wormian bones (HP:0002645)1.56221225
176Spontaneous abortion (HP:0005268)1.55871409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.38441759
2ERN13.75794123
3PBK3.74634556
4TRIB32.98818703
5SCYL22.92940265
6VRK22.38857029
7TAOK32.30727734
8PKN22.27498941
9IRAK32.26778747
10INSRR2.22292047
11FLT32.21074417
12SRPK12.20472290
13BRSK22.18331060
14TESK12.17838666
15SMG12.11741707
16EPHA22.11140213
17BUB12.06372931
18PDK21.98793429
19EEF2K1.97879846
20BCKDK1.96525587
21WEE11.91107332
22ICK1.74396423
23EIF2AK31.73884656
24TESK21.72548311
25SIK11.55648985
26MAPK151.49603283
27FRK1.49383844
28PAK41.44697337
29ERBB41.44592901
30CDK121.42668501
31PDGFRA1.41629823
32PTK61.40231216
33LRRK21.32541444
34PLK31.27450322
35NEK21.24167659
36TSSK61.23446165
37EIF2AK11.22636656
38RPS6KA41.19466983
39MAP3K31.19378279
40STK161.19049263
41RPS6KB21.15790453
42TGFBR11.15726412
43LMTK21.12591354
44CDC71.09227668
45CDK81.08921963
46NME21.07019457
47HIPK21.05701442
48KDR1.04258604
49LATS21.01591920
50MST40.99582624
51MAP3K120.99501312
52MAP3K20.99186716
53RIPK10.97102530
54TTN0.96445815
55MAP3K80.95454746
56PAK20.94540108
57PTK20.93618236
58MAPKAPK30.92917879
59ZAP700.92397261
60MAP2K30.91666340
61TRIM280.90934642
62MAP2K20.90599209
63STK100.89780761
64MET0.88514494
65FGFR10.87529360
66NEK10.85925676
67BCR0.84646102
68JAK30.83761982
69PLK40.82393093
70ACVR1B0.79418372
71PIK3CG0.78515546
72TTK0.78008210
73DDR20.77831871
74MAP3K100.77340687
75PIM20.76801195
76ARAF0.75256144
77CHEK20.74990654
78DYRK1B0.74649022
79PRKD30.74596946
80AURKB0.73615472
81BRSK10.73451852
82EPHA30.72517123
83NME10.71198108
84IRAK10.68082783
85ATR0.68031347
86MTOR0.67364617
87BTK0.65950180
88NEK90.64164717
89IRAK40.61751376
90FGFR40.61654320
91CAMKK20.61443107
92NTRK10.60115329
93CDK70.59790002
94PRKCI0.58521430
95WNK40.58420664
96TGFBR20.57705642
97DAPK10.57609803
98MAPK110.56671014
99FGFR30.56215578
100LATS10.54145407
101FER0.53641514
102PLK10.52864682
103TEC0.52595844
104MAP3K10.50901847
105AKT20.49429783
106MKNK10.47408102
107STK30.47002837
108ILK0.46957131
109EIF2AK20.46919863
110ABL20.45694592
111DYRK30.45475560
112AKT30.45463666
113CSNK2A10.44051381
114CSNK2A20.43199987
115ATM0.42311482
116CDK180.42024424
117CDK90.41631788
118SIK30.41502064
119TYK20.41388628
120TBK10.40585925
121ZAK0.40338600
122TAF10.39993172
123JAK20.39771124
124LIMK10.39744084
125CLK10.39721501
126ITK0.39649986
127CDK40.39354811
128PAK10.38054543
129CDK150.37753082
130CDK140.37422646
131CDK10.37272140
132AURKA0.36406338
133CSNK1G30.36201432
134EPHB10.35935877
135BMX0.35518762
136CHEK10.34703284
137PDK40.33629635
138PDK30.33629635
139CDK60.33515400
140VRK10.32507511
141MST1R0.32278454
142MAP3K110.29358725

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.23499678
2Protein export_Homo sapiens_hsa030605.12269609
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.07441861
4* N-Glycan biosynthesis_Homo sapiens_hsa005102.56150577
5DNA replication_Homo sapiens_hsa030302.45107196
6Other glycan degradation_Homo sapiens_hsa005112.43698151
7Sulfur metabolism_Homo sapiens_hsa009202.35941347
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.31268607
9Selenocompound metabolism_Homo sapiens_hsa004502.30508901
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16963578
11Fatty acid elongation_Homo sapiens_hsa000622.15336069
12Steroid biosynthesis_Homo sapiens_hsa001002.11131029
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.02370436
14One carbon pool by folate_Homo sapiens_hsa006702.00560556
15Lysosome_Homo sapiens_hsa041421.90813805
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87286127
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77836208
18Antigen processing and presentation_Homo sapiens_hsa046121.73535484
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72497261
20Galactose metabolism_Homo sapiens_hsa000521.61160252
21Mismatch repair_Homo sapiens_hsa034301.59525061
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51909356
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50625982
24Folate biosynthesis_Homo sapiens_hsa007901.47396591
25Complement and coagulation cascades_Homo sapiens_hsa046101.46497005
26Proteasome_Homo sapiens_hsa030501.45217513
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.38388904
28RNA transport_Homo sapiens_hsa030131.30091358
29Renin-angiotensin system_Homo sapiens_hsa046141.21038419
30Base excision repair_Homo sapiens_hsa034101.16204514
31Pyrimidine metabolism_Homo sapiens_hsa002401.15978441
32Legionellosis_Homo sapiens_hsa051341.14929686
33Vibrio cholerae infection_Homo sapiens_hsa051101.13432811
34Cell cycle_Homo sapiens_hsa041101.10699481
35Protein digestion and absorption_Homo sapiens_hsa049741.05897123
36Spliceosome_Homo sapiens_hsa030401.05800718
37Propanoate metabolism_Homo sapiens_hsa006401.04323051
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04175591
39Ribosome_Homo sapiens_hsa030101.02519167
40Vitamin digestion and absorption_Homo sapiens_hsa049771.02135896
41Pentose phosphate pathway_Homo sapiens_hsa000300.99972234
42Arginine biosynthesis_Homo sapiens_hsa002200.98331490
43Nucleotide excision repair_Homo sapiens_hsa034200.98329598
44Vitamin B6 metabolism_Homo sapiens_hsa007500.96981298
45Fat digestion and absorption_Homo sapiens_hsa049750.93009713
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90939739
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86008402
48p53 signaling pathway_Homo sapiens_hsa041150.85709058
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.84677727
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84029553
51Fructose and mannose metabolism_Homo sapiens_hsa000510.82564676
52Bladder cancer_Homo sapiens_hsa052190.82279063
53ECM-receptor interaction_Homo sapiens_hsa045120.82129672
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81509693
55Homologous recombination_Homo sapiens_hsa034400.79862967
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77582627
57Starch and sucrose metabolism_Homo sapiens_hsa005000.76569172
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75295223
59Biosynthesis of amino acids_Homo sapiens_hsa012300.74439733
60Viral carcinogenesis_Homo sapiens_hsa052030.70888562
61Tyrosine metabolism_Homo sapiens_hsa003500.68570113
62Phenylalanine metabolism_Homo sapiens_hsa003600.66223097
63Thyroid cancer_Homo sapiens_hsa052160.65948519
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64563840
65Carbon metabolism_Homo sapiens_hsa012000.64441244
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64174493
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63547494
68Fatty acid biosynthesis_Homo sapiens_hsa000610.63315844
69Tryptophan metabolism_Homo sapiens_hsa003800.61478555
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61393621
71mRNA surveillance pathway_Homo sapiens_hsa030150.61168298
72Thyroid hormone synthesis_Homo sapiens_hsa049180.59455328
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58972035
74Insulin resistance_Homo sapiens_hsa049310.58237013
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57486453
76Glutathione metabolism_Homo sapiens_hsa004800.55998455
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.55997525
78Small cell lung cancer_Homo sapiens_hsa052220.54995074
79Peroxisome_Homo sapiens_hsa041460.53734716
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53308993
81Type I diabetes mellitus_Homo sapiens_hsa049400.53134987
82Fatty acid degradation_Homo sapiens_hsa000710.51766166
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51547469
84RNA polymerase_Homo sapiens_hsa030200.50892922
85Non-homologous end-joining_Homo sapiens_hsa034500.50160536
86ABC transporters_Homo sapiens_hsa020100.49074357
87Focal adhesion_Homo sapiens_hsa045100.48208401
88Caffeine metabolism_Homo sapiens_hsa002320.47539899
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.46101072
90Epstein-Barr virus infection_Homo sapiens_hsa051690.45299097
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44574357
92Chronic myeloid leukemia_Homo sapiens_hsa052200.44228265
93Prion diseases_Homo sapiens_hsa050200.44060118
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43205672
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42778776
96Arginine and proline metabolism_Homo sapiens_hsa003300.42156882
97Purine metabolism_Homo sapiens_hsa002300.41602641
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.39879819
99Phagosome_Homo sapiens_hsa041450.39827486
100Sulfur relay system_Homo sapiens_hsa041220.39698544
101PPAR signaling pathway_Homo sapiens_hsa033200.39505999
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38564591
103HTLV-I infection_Homo sapiens_hsa051660.37648674
104Sphingolipid metabolism_Homo sapiens_hsa006000.36441778
105Lysine degradation_Homo sapiens_hsa003100.35278324
106Pyruvate metabolism_Homo sapiens_hsa006200.35249128
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35215245
108Apoptosis_Homo sapiens_hsa042100.34370305
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33847924
110Prostate cancer_Homo sapiens_hsa052150.33761539
111Type II diabetes mellitus_Homo sapiens_hsa049300.32499467
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31116533
113Pancreatic secretion_Homo sapiens_hsa049720.30698656
114Hippo signaling pathway_Homo sapiens_hsa043900.30141711
115Systemic lupus erythematosus_Homo sapiens_hsa053220.29717377
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29434543
117Fanconi anemia pathway_Homo sapiens_hsa034600.29024336
118RNA degradation_Homo sapiens_hsa030180.27305991
119Fatty acid metabolism_Homo sapiens_hsa012120.26764371
120Proteoglycans in cancer_Homo sapiens_hsa052050.26754577
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26409734
122Adherens junction_Homo sapiens_hsa045200.25888709
123* Metabolic pathways_Homo sapiens_hsa011000.25135398
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24711265
125Amoebiasis_Homo sapiens_hsa051460.23691183
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.23645612

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