RPP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.64098372
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.22178418
3ATP synthesis coupled proton transport (GO:0015986)6.22178418
4ribosomal small subunit assembly (GO:0000028)5.99918092
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.44956310
6ribosomal small subunit biogenesis (GO:0042274)5.40576056
7proteasome assembly (GO:0043248)5.28289428
8viral transcription (GO:0019083)5.21370860
9translational termination (GO:0006415)5.02962874
10respiratory electron transport chain (GO:0022904)4.98275434
11DNA deamination (GO:0045006)4.93090189
12electron transport chain (GO:0022900)4.85029321
13maturation of SSU-rRNA (GO:0030490)4.77532130
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.74088898
15cotranslational protein targeting to membrane (GO:0006613)4.73458612
16protein targeting to ER (GO:0045047)4.65350645
17protein complex biogenesis (GO:0070271)4.65067700
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.59495884
19NADH dehydrogenase complex assembly (GO:0010257)4.59495884
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.59495884
21ribosomal large subunit biogenesis (GO:0042273)4.53407247
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.47669694
23termination of RNA polymerase III transcription (GO:0006386)4.47669694
24protein localization to endoplasmic reticulum (GO:0070972)4.46169277
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40371476
26translational elongation (GO:0006414)4.32735220
27regulation of mitochondrial translation (GO:0070129)4.27560471
28mitochondrial respiratory chain complex assembly (GO:0033108)4.26673896
29chaperone-mediated protein transport (GO:0072321)4.14311360
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.14164437
31viral life cycle (GO:0019058)4.05654261
32translation (GO:0006412)4.04816557
33GTP biosynthetic process (GO:0006183)4.03294000
34cellular protein complex disassembly (GO:0043624)4.02449558
35protein neddylation (GO:0045116)4.01626184
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.00191197
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.00191197
38translational initiation (GO:0006413)3.92063430
39respiratory chain complex IV assembly (GO:0008535)3.91902183
40regulation of cellular amino acid metabolic process (GO:0006521)3.89096044
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84250116
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.80677534
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.78742575
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77489164
45negative regulation of ligase activity (GO:0051352)3.77489164
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76937302
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76937302
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76937302
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.76769600
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.76769600
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76739655
527-methylguanosine mRNA capping (GO:0006370)3.72917251
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71608010
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70389969
55inner mitochondrial membrane organization (GO:0007007)3.69633932
56guanosine-containing compound biosynthetic process (GO:1901070)3.68715218
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66495237
58RNA capping (GO:0036260)3.66025834
597-methylguanosine RNA capping (GO:0009452)3.66025834
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.64010000
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64010000
62cytochrome complex assembly (GO:0017004)3.61501047
63oxidative phosphorylation (GO:0006119)3.59831918
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.59737304
65protein targeting to mitochondrion (GO:0006626)3.59276001
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58887972
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.58840841
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53716497
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52054026
70cellular component biogenesis (GO:0044085)3.50357025
71DNA damage response, detection of DNA damage (GO:0042769)3.50292187
72establishment of protein localization to mitochondrion (GO:0072655)3.47321737
73UTP biosynthetic process (GO:0006228)3.46465915
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45509869
75chromatin remodeling at centromere (GO:0031055)3.45158836
76ribonucleoprotein complex biogenesis (GO:0022613)3.45067030
77iron-sulfur cluster assembly (GO:0016226)3.44384027
78metallo-sulfur cluster assembly (GO:0031163)3.44384027
79protein-cofactor linkage (GO:0018065)3.44308690
80rRNA modification (GO:0000154)3.41959829
81protein complex disassembly (GO:0043241)3.36618286
82pseudouridine synthesis (GO:0001522)3.36604641
83CENP-A containing nucleosome assembly (GO:0034080)3.34848750
84telomere maintenance via semi-conservative replication (GO:0032201)3.34486633
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27743298
86macromolecular complex disassembly (GO:0032984)3.26249208
87ribonucleoside triphosphate biosynthetic process (GO:0009201)3.24427299
88intracellular protein transmembrane import (GO:0044743)3.23359738
89kinetochore assembly (GO:0051382)3.21411921
90rRNA processing (GO:0006364)3.21407339
91purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19694372
92protein localization to mitochondrion (GO:0070585)3.16860647
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16726302
94transcription-coupled nucleotide-excision repair (GO:0006283)3.14342632
95nuclear-transcribed mRNA catabolic process (GO:0000956)3.14208468
96transcription elongation from RNA polymerase I promoter (GO:0006362)3.12412894
97GDP-mannose metabolic process (GO:0019673)3.12333193
98proton transport (GO:0015992)3.11115627
99CTP biosynthetic process (GO:0006241)3.10169626
100CTP metabolic process (GO:0046036)3.10169626
101positive regulation of ligase activity (GO:0051351)3.08994414
102protein targeting to membrane (GO:0006612)3.07481103
103spliceosomal snRNP assembly (GO:0000387)3.07249193
104rRNA metabolic process (GO:0016072)3.06542943
105ATP biosynthetic process (GO:0006754)3.06157383
106termination of RNA polymerase I transcription (GO:0006363)3.05640132
107hydrogen ion transmembrane transport (GO:1902600)3.04811769
108hydrogen transport (GO:0006818)3.04243315
109peptidyl-histidine modification (GO:0018202)3.03812235
110viral mRNA export from host cell nucleus (GO:0046784)3.02631647
111transcription from RNA polymerase I promoter (GO:0006360)3.01993802
112cullin deneddylation (GO:0010388)3.01859977
113mitochondrial transport (GO:0006839)3.01794786
114pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00961369
115DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.00760608
116water-soluble vitamin biosynthetic process (GO:0042364)2.98981781
117resolution of meiotic recombination intermediates (GO:0000712)2.98937302
118rRNA methylation (GO:0031167)2.98261059
119mannosylation (GO:0097502)2.97451793
120mRNA catabolic process (GO:0006402)2.95910789
121nucleoside triphosphate biosynthetic process (GO:0009142)2.93930809
122kinetochore organization (GO:0051383)2.92588507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01802388
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.55270046
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29068476
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.28634614
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.16125989
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.94712324
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.68750236
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.62909309
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34361702
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30787688
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30149171
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26527942
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17421027
14ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11474105
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.07403038
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05889810
17E2F7_22180533_ChIP-Seq_HELA_Human2.93785644
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90225325
19VDR_23849224_ChIP-Seq_CD4+_Human2.86659705
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.63061266
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46517209
22DCP1A_22483619_ChIP-Seq_HELA_Human2.42316769
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38344029
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38194602
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.33031213
26FOXP3_21729870_ChIP-Seq_TREG_Human2.32577223
27* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29322318
28ELK1_19687146_ChIP-ChIP_HELA_Human2.20634471
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17369114
30XRN2_22483619_ChIP-Seq_HELA_Human2.14312090
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10204187
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04801222
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03306997
34TTF2_22483619_ChIP-Seq_HELA_Human1.98355478
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98285256
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94478383
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92671101
38GABP_19822575_ChIP-Seq_HepG2_Human1.91401596
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86271759
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85353997
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80663923
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72529366
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.70591516
44ZNF274_21170338_ChIP-Seq_K562_Hela1.61519747
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60444145
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59141017
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57104861
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.53861174
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53321439
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53068631
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52289046
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45832167
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45256920
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45191844
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42477338
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42323810
57MYC_18940864_ChIP-ChIP_HL60_Human1.31093722
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30450992
59IRF1_19129219_ChIP-ChIP_H3396_Human1.29351834
60CIITA_25753668_ChIP-Seq_RAJI_Human1.26365484
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25082242
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23980143
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19299597
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16199410
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16068696
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14205490
67SPI1_23547873_ChIP-Seq_NB4_Human1.13157416
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12577829
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.11454528
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02595795
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.00557115
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98239272
73STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97152754
74EWS_26573619_Chip-Seq_HEK293_Human0.96268271
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94802373
76FOXP1_21924763_ChIP-Seq_HESCs_Human0.93905902
77EZH2_22144423_ChIP-Seq_EOC_Human0.93356657
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92956500
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92465790
80TP53_22573176_ChIP-Seq_HFKS_Human0.91504416
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.91044204
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90696379
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90043713
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.88713634
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.87770334
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87633822
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87518770
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86733495
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85124010
90KDM5A_27292631_Chip-Seq_BREAST_Human0.84822481
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84260092
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84020544
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83662332
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83483642
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.82936640
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81823952
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80374625
98VDR_22108803_ChIP-Seq_LS180_Human0.78593214
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78498898
100* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77968518
101FOXM1_23109430_ChIP-Seq_U2OS_Human0.76338584
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76226129
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75933339
104SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75660332
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74735292
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74218145
107IRF8_22096565_ChIP-ChIP_GC-B_Human0.73851723
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73567613
109FUS_26573619_Chip-Seq_HEK293_Human0.72216919
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71344461
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70952875
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70812236
113E2F1_21310950_ChIP-Seq_MCF-7_Human0.70321360
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69957753
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69391754
116NANOG_20526341_ChIP-Seq_ESCs_Human0.68203675
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.67762878
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.65950765
119STAT1_20625510_ChIP-Seq_HELA_Human0.65912855
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.65269534
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.64091467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.70306607
2MP0003693_abnormal_embryo_hatching3.53172910
3MP0001529_abnormal_vocalization3.30231883
4MP0004957_abnormal_blastocyst_morpholog2.60425701
5MP0005671_abnormal_response_to2.29044479
6MP0001905_abnormal_dopamine_level2.26520143
7MP0006292_abnormal_olfactory_placode2.21834690
8MP0002132_abnormal_respiratory_system2.19189626
9MP0008058_abnormal_DNA_repair2.18675608
10MP0001835_abnormal_antigen_presentation2.14137166
11MP0010030_abnormal_orbit_morphology2.11690451
12MP0003718_maternal_effect2.08755487
13MP0006036_abnormal_mitochondrial_physio2.08421435
14MP0002148_abnormal_hypersensitivity_rea2.07009072
15MP0001986_abnormal_taste_sensitivity2.00970629
16MP0003123_paternal_imprinting2.00141415
17MP0002234_abnormal_pharynx_morphology1.99143715
18MP0010094_abnormal_chromosome_stability1.98776766
19MP0003186_abnormal_redox_activity1.97717909
20MP0002837_dystrophic_cardiac_calcinosis1.93436718
21MP0006035_abnormal_mitochondrial_morpho1.83607504
22MP0001293_anophthalmia1.83594453
23MP0003077_abnormal_cell_cycle1.81500004
24MP0009785_altered_susceptibility_to1.81481223
25MP0008057_abnormal_DNA_replication1.81133885
26MP0003786_premature_aging1.80103366
27MP0005394_taste/olfaction_phenotype1.75435033
28MP0005499_abnormal_olfactory_system1.75435033
29MP0000372_irregular_coat_pigmentation1.74667716
30MP0009333_abnormal_splenocyte_physiolog1.74317826
31MP0008932_abnormal_embryonic_tissue1.73587874
32MP0003136_yellow_coat_color1.73176002
33MP0003111_abnormal_nucleus_morphology1.72754224
34MP0003880_abnormal_central_pattern1.72201125
35MP0001188_hyperpigmentation1.72115680
36MP0003121_genomic_imprinting1.69211095
37MP0003763_abnormal_thymus_physiology1.67004353
38MP0000015_abnormal_ear_pigmentation1.65381577
39MP0005075_abnormal_melanosome_morpholog1.64506414
40MP0001853_heart_inflammation1.62474437
41MP0002638_abnormal_pupillary_reflex1.62239492
42MP0004147_increased_porphyrin_level1.59924289
43MP0002163_abnormal_gland_morphology1.58835587
44MP0000631_abnormal_neuroendocrine_gland1.56637485
45MP0000049_abnormal_middle_ear1.56318472
46MP0005174_abnormal_tail_pigmentation1.51407239
47MP0009697_abnormal_copulation1.50485931
48MP0006072_abnormal_retinal_apoptosis1.46473788
49MP0003011_delayed_dark_adaptation1.44996475
50MP0002653_abnormal_ependyma_morphology1.44575328
51MP0003724_increased_susceptibility_to1.42254347
52MP0004142_abnormal_muscle_tone1.39091033
53MP0005646_abnormal_pituitary_gland1.38879268
54MP0003787_abnormal_imprinting1.37282397
55MP0004381_abnormal_hair_follicle1.37246081
56MP0003122_maternal_imprinting1.36928345
57MP0005000_abnormal_immune_tolerance1.35422056
58MP0005025_abnormal_response_to1.34463169
59MP0002160_abnormal_reproductive_system1.33512860
60MP0005645_abnormal_hypothalamus_physiol1.31528757
61MP0006276_abnormal_autonomic_nervous1.30410082
62MP0004133_heterotaxia1.29853850
63MP0003195_calcinosis1.29749843
64MP0002210_abnormal_sex_determination1.27080279
65MP0003806_abnormal_nucleotide_metabolis1.26878322
66MP0005551_abnormal_eye_electrophysiolog1.25603183
67MP0002420_abnormal_adaptive_immunity1.25540390
68MP0008260_abnormal_autophagy1.25341494
69MP0001819_abnormal_immune_cell1.23816650
70MP0002396_abnormal_hematopoietic_system1.22628530
71MP0001764_abnormal_homeostasis1.22314243
72MP0008875_abnormal_xenobiotic_pharmacok1.21978034
73MP0002723_abnormal_immune_serum1.21088184
74MP0000566_synostosis1.20813350
75MP0005409_darkened_coat_color1.20452099
76MP0000490_abnormal_crypts_of1.18974116
77MP0002736_abnormal_nociception_after1.18691154
78MP0009046_muscle_twitch1.18155719
79MP0003866_abnormal_defecation1.16040436
80MP0002277_abnormal_respiratory_mucosa1.15984382
81MP0003315_abnormal_perineum_morphology1.15767411
82MP0002876_abnormal_thyroid_physiology1.15419418
83MP0002095_abnormal_skin_pigmentation1.14086593
84MP0008877_abnormal_DNA_methylation1.13007863
85MP0005379_endocrine/exocrine_gland_phen1.11842841
86MP0002452_abnormal_antigen_presenting1.11290649
87MP0002405_respiratory_system_inflammati1.08284973
88MP0003938_abnormal_ear_development1.07929887
89MP0001800_abnormal_humoral_immune1.07553889
90MP0008007_abnormal_cellular_replicative1.07528485
91MP0002938_white_spotting1.07288347
92MP0005389_reproductive_system_phenotype1.06336095
93MP0009745_abnormal_behavioral_response1.05512829
94MP0002398_abnormal_bone_marrow1.05122713
95MP0000716_abnormal_immune_system1.00119874
96MP0002822_catalepsy0.98874627
97MP0002419_abnormal_innate_immunity0.97407327
98MP0010386_abnormal_urinary_bladder0.96989165
99MP0000689_abnormal_spleen_morphology0.96214807
100MP0001968_abnormal_touch/_nociception0.95799476
101MP0000653_abnormal_sex_gland0.95583236
102MP0002722_abnormal_immune_system0.95085838
103MP0001929_abnormal_gametogenesis0.95057597
104MP0005253_abnormal_eye_physiology0.94831470
105MP0001145_abnormal_male_reproductive0.94399327
106MP0002429_abnormal_blood_cell0.92857121
107MP0002233_abnormal_nose_morphology0.92008599
108MP0001727_abnormal_embryo_implantation0.91551966
109MP0005084_abnormal_gallbladder_morpholo0.91549246
110MP0001984_abnormal_olfaction0.91245648
111MP0002102_abnormal_ear_morphology0.88626728
112MP0001542_abnormal_bone_strength0.88427436
113MP0003937_abnormal_limbs/digits/tail_de0.87802647
114MP0005408_hypopigmentation0.87586459
115MP0000026_abnormal_inner_ear0.87127803
116MP0004782_abnormal_surfactant_physiolog0.87024870
117MP0003698_abnormal_male_reproductive0.85876490
118MP0003119_abnormal_digestive_system0.84966331
119MP0005332_abnormal_amino_acid0.82330699
120MP0006082_CNS_inflammation0.82144173
121MP0001919_abnormal_reproductive_system0.81884436
122MP0008789_abnormal_olfactory_epithelium0.81620155
123MP0002557_abnormal_social/conspecific_i0.80425131
124MP0003646_muscle_fatigue0.80153420
125MP0001485_abnormal_pinna_reflex0.79913762
126MP0001286_abnormal_eye_development0.79905170
127MP0000313_abnormal_cell_death0.79835581
128MP0005195_abnormal_posterior_eye0.79729374
129MP0008995_early_reproductive_senescence0.78826258
130MP0003137_abnormal_impulse_conducting0.78725388
131MP0002752_abnormal_somatic_nervous0.77998821
132MP0003567_abnormal_fetal_cardiomyocyte0.77894066
133MP0000647_abnormal_sebaceous_gland0.77254132
134MP0005387_immune_system_phenotype0.77243128
135MP0001790_abnormal_immune_system0.77243128
136MP0002751_abnormal_autonomic_nervous0.76943123
137MP0008004_abnormal_stomach_pH0.76251057
138MP0004019_abnormal_vitamin_homeostasis0.75234510
139MP0003890_abnormal_embryonic-extraembry0.75185474
140MP0005171_absent_coat_pigmentation0.74823839
141MP0004742_abnormal_vestibular_system0.74804512
142MP0005636_abnormal_mineral_homeostasis0.74616446
143MP0000778_abnormal_nervous_system0.72715200
144MP0000703_abnormal_thymus_morphology0.72525300
145MP0002735_abnormal_chemical_nociception0.71983653
146MP0008872_abnormal_physiological_respon0.71979255
147MP0010155_abnormal_intestine_physiology0.70958817
148MP0008469_abnormal_protein_level0.67698762
149MP0000685_abnormal_immune_system0.67128430
150MP0000681_abnormal_thyroid_gland0.65979422
151MP0002272_abnormal_nervous_system0.65755633

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.89588013
2Mitochondrial inheritance (HP:0001427)5.63938454
3Abnormal mitochondria in muscle tissue (HP:0008316)5.29745806
4Increased hepatocellular lipid droplets (HP:0006565)5.16463848
5Hepatocellular necrosis (HP:0001404)5.02828229
6Increased CSF lactate (HP:0002490)4.85407410
7Progressive macrocephaly (HP:0004481)4.79652418
8Acute encephalopathy (HP:0006846)4.67258266
9Abnormality of cells of the erythroid lineage (HP:0012130)4.58873669
10Lipid accumulation in hepatocytes (HP:0006561)4.48729436
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.47314481
12Renal Fanconi syndrome (HP:0001994)4.46213986
13Hepatic necrosis (HP:0002605)4.41060536
14Abnormal number of erythroid precursors (HP:0012131)4.30919987
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.26405598
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.26405598
173-Methylglutaconic aciduria (HP:0003535)4.25680200
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.20166238
19Reticulocytopenia (HP:0001896)4.00583515
20Exertional dyspnea (HP:0002875)3.83540308
21Increased intramyocellular lipid droplets (HP:0012240)3.70970817
22Increased serum lactate (HP:0002151)3.60802593
23Respiratory difficulties (HP:0002880)3.56413104
24Exercise intolerance (HP:0003546)3.32934031
25Macrocytic anemia (HP:0001972)3.32176274
26Respiratory failure (HP:0002878)3.24861316
27Lactic acidosis (HP:0003128)3.19641221
28Abnormality of glycolysis (HP:0004366)3.18662883
29Increased serum pyruvate (HP:0003542)3.18662883
30Increased muscle lipid content (HP:0009058)3.03708806
31Type I transferrin isoform profile (HP:0003642)3.01215274
32Abnormality of renal resorption (HP:0011038)3.01012482
33Pallor (HP:0000980)2.96646544
34Cerebral edema (HP:0002181)2.94171620
35Optic disc pallor (HP:0000543)2.86950213
36Abnormality of midbrain morphology (HP:0002418)2.86068540
37Molar tooth sign on MRI (HP:0002419)2.86068540
38Aplastic anemia (HP:0001915)2.81443764
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74779012
40Leukodystrophy (HP:0002415)2.69946284
41Hyperglycinemia (HP:0002154)2.61075613
42Birth length less than 3rd percentile (HP:0003561)2.59868378
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.57796902
44Pancreatic fibrosis (HP:0100732)2.57721106
45Methylmalonic acidemia (HP:0002912)2.55416837
46Microvesicular hepatic steatosis (HP:0001414)2.54258330
47Cerebral hypomyelination (HP:0006808)2.51230196
48Methylmalonic aciduria (HP:0012120)2.46805562
49Septo-optic dysplasia (HP:0100842)2.41644627
50Sclerocornea (HP:0000647)2.39377646
51Oral leukoplakia (HP:0002745)2.37674339
52Colon cancer (HP:0003003)2.33844894
53Glycosuria (HP:0003076)2.33383694
54Abnormality of urine glucose concentration (HP:0011016)2.33383694
55Rough bone trabeculation (HP:0100670)2.30914277
56Absent thumb (HP:0009777)2.30875112
57True hermaphroditism (HP:0010459)2.30774578
58Abnormality of the labia minora (HP:0012880)2.26799544
59IgM deficiency (HP:0002850)2.18265296
60CNS demyelination (HP:0007305)2.17594316
61Pendular nystagmus (HP:0012043)2.15349048
62Hyperphosphaturia (HP:0003109)2.12606181
63Nephronophthisis (HP:0000090)2.10071525
64Aplasia/hypoplasia of the uterus (HP:0008684)2.09046347
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07663491
66Abnormal protein N-linked glycosylation (HP:0012347)2.07663491
67Abnormal protein glycosylation (HP:0012346)2.07663491
68Abnormal glycosylation (HP:0012345)2.07663491
69Breast hypoplasia (HP:0003187)2.07350911
70Emotional lability (HP:0000712)2.06667061
71Congenital primary aphakia (HP:0007707)2.06506573
72Pancytopenia (HP:0001876)2.05577964
73Gait imbalance (HP:0002141)2.05050894
74Abnormal hair whorl (HP:0010721)2.03400358
75Abnormality of placental membranes (HP:0011409)2.02794526
76Amniotic constriction ring (HP:0009775)2.02794526
77Generalized aminoaciduria (HP:0002909)2.00730309
78Nephrogenic diabetes insipidus (HP:0009806)1.99524965
79Renal tubular dysfunction (HP:0000124)1.93589482
80Parakeratosis (HP:0001036)1.91675455
81Premature graying of hair (HP:0002216)1.88468375
82Congenital ichthyosiform erythroderma (HP:0007431)1.84270824
83Abnormal trabecular bone morphology (HP:0100671)1.83848660
84Elevated erythrocyte sedimentation rate (HP:0003565)1.81983090
85Meckel diverticulum (HP:0002245)1.81609831
86Abnormality of the preputium (HP:0100587)1.80316011
87Rib fusion (HP:0000902)1.78142104
88Abnormal rod and cone electroretinograms (HP:0008323)1.78004770
89Poor head control (HP:0002421)1.77723987
90Reduced antithrombin III activity (HP:0001976)1.77509038
91Triphalangeal thumb (HP:0001199)1.76820291
92Congenital, generalized hypertrichosis (HP:0004540)1.76486059
93Absent septum pellucidum (HP:0001331)1.76219785
94Poor suck (HP:0002033)1.74728082
9511 pairs of ribs (HP:0000878)1.73600250
96Hypoplasia of the pons (HP:0012110)1.73455438
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73237950
98Anencephaly (HP:0002323)1.72905730
99Type 2 muscle fiber atrophy (HP:0003554)1.72770401
100Abnormality of the ileum (HP:0001549)1.72137215
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.72117880
102Adrenal hypoplasia (HP:0000835)1.70041547
103IgG deficiency (HP:0004315)1.69899514
104Abnormality of serum amino acid levels (HP:0003112)1.69613425
105Testicular atrophy (HP:0000029)1.69478580
106Petechiae (HP:0000967)1.69374460
107Medial flaring of the eyebrow (HP:0010747)1.69177936
108Abnormal urine phosphate concentration (HP:0012599)1.69141780
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68364323
110Abnormality of alanine metabolism (HP:0010916)1.68364323
111Hyperalaninemia (HP:0003348)1.68364323
112Congenital stationary night blindness (HP:0007642)1.66735405
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.66442752
114Recurrent abscess formation (HP:0002722)1.66435345
115Lethargy (HP:0001254)1.65680693
116Hypoplasia of the uterus (HP:0000013)1.65093280
117Blindness (HP:0000618)1.64343131
118Myokymia (HP:0002411)1.64117455
119Bone marrow hypocellularity (HP:0005528)1.63715064
120Cleft eyelid (HP:0000625)1.63374489
121Muscle fiber atrophy (HP:0100295)1.63026539
122Cellular immunodeficiency (HP:0005374)1.61945111
123Abnormal number of incisors (HP:0011064)1.61895034
124X-linked dominant inheritance (HP:0001423)1.61115414
125Trismus (HP:0000211)1.59846838
126Hepatosplenomegaly (HP:0001433)1.59518294
127Sparse eyelashes (HP:0000653)1.59096700
128Abnormality of the anterior horn cell (HP:0006802)1.59065430
129Degeneration of anterior horn cells (HP:0002398)1.59065430
130Secondary amenorrhea (HP:0000869)1.58498448
131Pancreatic cysts (HP:0001737)1.58377186
132CNS hypomyelination (HP:0003429)1.56915661
133Gliosis (HP:0002171)1.53437500
134Microretrognathia (HP:0000308)1.53277267
135Vacuolated lymphocytes (HP:0001922)1.53101717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.98698416
2STK164.47221085
3BUB13.50607514
4NME23.22974705
5NME13.18865570
6MAP3K122.86569544
7WNK32.57194462
8EIF2AK12.44613299
9VRK12.43116472
10TLK12.33075355
11SRPK12.28108037
12WEE12.21282332
13BCKDK2.18347710
14MAP4K22.17016467
15ARAF2.15151885
16PIM22.12284310
17TRIM282.04913850
18PBK1.91289849
19EIF2AK31.90199841
20MST41.84248997
21NEK11.83108205
22MUSK1.82344421
23IRAK41.81821462
24BMPR1B1.79840555
25PLK41.74666909
26IRAK31.70778729
27ACVR1B1.68249939
28TXK1.62593828
29TSSK61.54559506
30TAF11.46576244
31ZAK1.46102123
32MYLK1.44472257
33CDK191.42419816
34BRAF1.35967346
35BLK1.27368207
36CASK1.23805976
37CCNB11.21106684
38PDK21.20298587
39MAP3K41.20088896
40LIMK11.17770234
41ADRBK21.11147760
42MKNK11.09566556
43GRK71.08096574
44MAP4K11.02271347
45TEC1.01321770
46KDR1.00423264
47TESK21.00103418
48CSNK1G20.96450390
49PASK0.94446204
50TNIK0.93427982
51DYRK20.92615176
52OXSR10.92416754
53EIF2AK20.88978551
54MAPKAPK50.87773444
55IRAK20.87614021
56BRSK20.85281856
57AURKA0.85046698
58STK390.83827789
59GRK50.80733100
60INSRR0.80457778
61CDK80.79836682
62PRKCG0.79445630
63LRRK20.78763513
64WNK40.77527302
65TESK10.77471984
66BMPR20.76128395
67PLK10.75998541
68SIK30.74941095
69MKNK20.74826054
70PINK10.74550777
71CSNK1A1L0.71069007
72FRK0.71044603
73CSNK1G30.70141652
74MAP2K70.69949460
75ABL20.68105964
76CSNK2A10.67371766
77EPHA40.66954785
78PNCK0.66278689
79PLK30.66210032
80TAOK30.65845264
81AURKB0.65345137
82AKT30.62657113
83CDC70.61860633
84LYN0.61449631
85RPS6KA50.61066943
86ZAP700.58571573
87ILK0.57978371
88SYK0.57928908
89YES10.57575778
90RPS6KB20.56842590
91CSNK2A20.56327415
92MAP3K110.55404469
93BCR0.54906914
94TTK0.54305830
95CLK10.54195462
96EPHB20.53462791
97KIT0.52799273
98EPHA20.51351657
99IKBKE0.50911881
100IRAK10.50251563
101MAP2K60.49205215
102PHKG20.49047585
103PHKG10.49047585
104CAMK2B0.48865684
105BTK0.46429985
106IKBKB0.45919416
107GRK10.45694273
108CSNK1A10.45533219
109PRKCI0.45388532
110PLK20.45289127
111DAPK30.44850832
112DAPK10.44214332
113CSNK1E0.43592859
114MAPK130.43403122
115PAK10.43379391
116ADRBK10.43200037
117DYRK30.43182863
118CHEK20.42402510
119PAK30.41737968
120STK40.41613236
121PRKCE0.39506582
122BRSK10.39249719
123MARK30.39077936
124ATR0.38838673
125PRKACA0.38752887
126OBSCN0.38658399
127FGFR20.38581135
128CSNK1G10.38559891
129NEK20.38423964
130UHMK10.38247857
131CDK70.36838866
132MARK10.36762193
133MINK10.36065532
134ATM0.35955441
135PRKCD0.35908129
136MAP3K140.35628223
137RPS6KA40.35583953
138RIPK40.34934856
139CHEK10.33843038
140NUAK10.33519034
141LCK0.33279435

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.09287688
2Oxidative phosphorylation_Homo sapiens_hsa001904.59472467
3Proteasome_Homo sapiens_hsa030504.58241827
4Parkinsons disease_Homo sapiens_hsa050123.96751798
5RNA polymerase_Homo sapiens_hsa030203.83566468
6Huntingtons disease_Homo sapiens_hsa050162.97898118
7Protein export_Homo sapiens_hsa030602.84589022
8Alzheimers disease_Homo sapiens_hsa050102.83702773
9DNA replication_Homo sapiens_hsa030302.74343220
10Mismatch repair_Homo sapiens_hsa034302.54570742
11Pyrimidine metabolism_Homo sapiens_hsa002402.49493168
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41423979
13Homologous recombination_Homo sapiens_hsa034402.17635084
14Spliceosome_Homo sapiens_hsa030402.12537868
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97441375
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90439655
17Nucleotide excision repair_Homo sapiens_hsa034201.87582608
18Base excision repair_Homo sapiens_hsa034101.85751440
19Basal transcription factors_Homo sapiens_hsa030221.55199385
20Purine metabolism_Homo sapiens_hsa002301.43178594
21Cardiac muscle contraction_Homo sapiens_hsa042601.41751058
22RNA degradation_Homo sapiens_hsa030181.38659733
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32640803
24Fanconi anemia pathway_Homo sapiens_hsa034601.32331701
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29262094
26* RNA transport_Homo sapiens_hsa030131.26269537
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24540073
28Non-homologous end-joining_Homo sapiens_hsa034501.22264251
29Collecting duct acid secretion_Homo sapiens_hsa049661.13480406
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06250818
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02988899
32Propanoate metabolism_Homo sapiens_hsa006401.01824825
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01096873
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.00767402
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99723522
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94810281
37Primary immunodeficiency_Homo sapiens_hsa053400.94383588
38Folate biosynthesis_Homo sapiens_hsa007900.94147102
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92499625
40Graft-versus-host disease_Homo sapiens_hsa053320.91302740
41Allograft rejection_Homo sapiens_hsa053300.88628270
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83908125
43Butanoate metabolism_Homo sapiens_hsa006500.82973764
44Arachidonic acid metabolism_Homo sapiens_hsa005900.80461784
45Fatty acid elongation_Homo sapiens_hsa000620.79610662
46Cell cycle_Homo sapiens_hsa041100.79127945
47Peroxisome_Homo sapiens_hsa041460.77316814
48Vibrio cholerae infection_Homo sapiens_hsa051100.76346135
49Epstein-Barr virus infection_Homo sapiens_hsa051690.75376295
50Metabolic pathways_Homo sapiens_hsa011000.74429886
51Glutathione metabolism_Homo sapiens_hsa004800.73459299
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.72151718
53Rheumatoid arthritis_Homo sapiens_hsa053230.71771944
54Asthma_Homo sapiens_hsa053100.71491780
55Regulation of autophagy_Homo sapiens_hsa041400.68867290
56Selenocompound metabolism_Homo sapiens_hsa004500.66306353
57Autoimmune thyroid disease_Homo sapiens_hsa053200.64046992
58Sulfur relay system_Homo sapiens_hsa041220.62296664
59Other glycan degradation_Homo sapiens_hsa005110.58105113
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57980798
61Caffeine metabolism_Homo sapiens_hsa002320.57529950
62One carbon pool by folate_Homo sapiens_hsa006700.57163489
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56905607
64Pentose phosphate pathway_Homo sapiens_hsa000300.55962965
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54794425
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52970968
67Hematopoietic cell lineage_Homo sapiens_hsa046400.52331241
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51998589
69Vitamin B6 metabolism_Homo sapiens_hsa007500.51644850
70Basal cell carcinoma_Homo sapiens_hsa052170.51458638
71Sphingolipid metabolism_Homo sapiens_hsa006000.49204198
72Chemical carcinogenesis_Homo sapiens_hsa052040.47965495
73Phototransduction_Homo sapiens_hsa047440.46883154
74Antigen processing and presentation_Homo sapiens_hsa046120.46879642
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46233013
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45281322
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44304496
78Tryptophan metabolism_Homo sapiens_hsa003800.44187252
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43883308
80Ether lipid metabolism_Homo sapiens_hsa005650.43371790
81Fructose and mannose metabolism_Homo sapiens_hsa000510.43159448
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42188994
83Sulfur metabolism_Homo sapiens_hsa009200.42037704
84Biosynthesis of amino acids_Homo sapiens_hsa012300.41447945
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40680800
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40600132
87p53 signaling pathway_Homo sapiens_hsa041150.40411089
88Type I diabetes mellitus_Homo sapiens_hsa049400.39353683
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.38989129
90Vitamin digestion and absorption_Homo sapiens_hsa049770.38911013
91beta-Alanine metabolism_Homo sapiens_hsa004100.37509449
92Linoleic acid metabolism_Homo sapiens_hsa005910.36697578
93Systemic lupus erythematosus_Homo sapiens_hsa053220.35803205
94N-Glycan biosynthesis_Homo sapiens_hsa005100.35569376
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35242572
96Tyrosine metabolism_Homo sapiens_hsa003500.35178804
97Hedgehog signaling pathway_Homo sapiens_hsa043400.33772119
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.33559104
99Retinol metabolism_Homo sapiens_hsa008300.33342072
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33202961
101Phagosome_Homo sapiens_hsa041450.32611648
102Legionellosis_Homo sapiens_hsa051340.32426487
103mRNA surveillance pathway_Homo sapiens_hsa030150.32410613
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.31895189
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31486531
106Oocyte meiosis_Homo sapiens_hsa041140.30741657
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.30273831
108Fat digestion and absorption_Homo sapiens_hsa049750.29039782
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28305117
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27794343
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27477531
112Herpes simplex infection_Homo sapiens_hsa051680.27427749
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27412359
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27267334
115Nitrogen metabolism_Homo sapiens_hsa009100.27250437
116Galactose metabolism_Homo sapiens_hsa000520.25431187
117Synaptic vesicle cycle_Homo sapiens_hsa047210.25282791
118Fatty acid degradation_Homo sapiens_hsa000710.24484270
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24337826
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20600217
121Steroid biosynthesis_Homo sapiens_hsa001000.19561001
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19323369
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19147287
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17837020
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.17260832
126Measles_Homo sapiens_hsa051620.15365818
127Pyruvate metabolism_Homo sapiens_hsa006200.12775723
128Shigellosis_Homo sapiens_hsa051310.12278114
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12091323
130Pertussis_Homo sapiens_hsa051330.11504151
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09796206
132Arginine and proline metabolism_Homo sapiens_hsa003300.09481976
133Nicotine addiction_Homo sapiens_hsa050330.09071022
134Alcoholism_Homo sapiens_hsa050340.07955095
135Carbon metabolism_Homo sapiens_hsa012000.07557115

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