RPP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.56801655
2maintenance of protein location in nucleus (GO:0051457)7.08409497
3regulation of response to osmotic stress (GO:0047484)6.77154223
4somite rostral/caudal axis specification (GO:0032525)6.74954407
5regulation of mammary gland epithelial cell proliferation (GO:0033599)6.74590104
6negative regulation of epidermis development (GO:0045683)6.57380504
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.45713113
8protein localization to kinetochore (GO:0034501)6.03130041
9negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)6.01897238
10muscle organ morphogenesis (GO:0048644)5.95931886
11regulation of nuclear cell cycle DNA replication (GO:0033262)5.85161870
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.80666614
13regulation of MHC class I biosynthetic process (GO:0045343)5.80365171
14regulation of telomere maintenance via telomerase (GO:0032210)5.75794489
15histone H4-K12 acetylation (GO:0043983)5.69319667
16negative regulation of telomerase activity (GO:0051974)5.69242990
17histone H4-K8 acetylation (GO:0043982)5.62839869
18histone H4-K5 acetylation (GO:0043981)5.62839869
19rRNA transcription (GO:0009303)5.42496178
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.36984919
21cytidine metabolic process (GO:0046087)5.20147595
22cytidine catabolic process (GO:0006216)5.20147595
23cytidine deamination (GO:0009972)5.20147595
24negative regulation of epidermal cell differentiation (GO:0045605)5.06180146
25mitotic sister chromatid segregation (GO:0000070)5.05566626
26phenol-containing compound catabolic process (GO:0019336)5.02714820
27notochord development (GO:0030903)5.01680452
28regulation of cilium movement (GO:0003352)5.00492977
29protein neddylation (GO:0045116)4.94064619
30hormone catabolic process (GO:0042447)4.93557861
31L-serine metabolic process (GO:0006563)4.91596137
32response to dietary excess (GO:0002021)4.82327447
33rRNA methylation (GO:0031167)4.77248997
34ribosomal small subunit biogenesis (GO:0042274)4.76237217
35heterochromatin organization (GO:0070828)4.74912674
36coenzyme catabolic process (GO:0009109)4.74237970
37regulation of retinoic acid receptor signaling pathway (GO:0048385)4.66759104
38nucleoside transmembrane transport (GO:1901642)4.58727941
39interferon-gamma production (GO:0032609)4.51020148
40primitive streak formation (GO:0090009)4.48561947
41quinone metabolic process (GO:1901661)4.48407682
42branching involved in mammary gland duct morphogenesis (GO:0060444)4.45257520
43positive regulation of DNA-dependent DNA replication (GO:2000105)4.40690979
44DNA unwinding involved in DNA replication (GO:0006268)4.35540198
45protein localization to chromosome, centromeric region (GO:0071459)4.34043511
46rRNA modification (GO:0000154)4.33772750
47regulation of apoptotic process involved in morphogenesis (GO:1902337)4.31090965
48mitochondrial fusion (GO:0008053)4.25305190
49negative regulation of telomere maintenance (GO:0032205)4.24254315
50DNA replication-dependent nucleosome organization (GO:0034723)4.23366799
51DNA replication-dependent nucleosome assembly (GO:0006335)4.23366799
52sister chromatid segregation (GO:0000819)4.15719625
53chromatin assembly (GO:0031497)4.15627028
54histone H4-K16 acetylation (GO:0043984)4.15133034
55regulation of translation in response to stress (GO:0043555)4.09878392
56epoxygenase P450 pathway (GO:0019373)4.01679843
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.97847655
58DNA replication checkpoint (GO:0000076)3.97372200
59maintenance of protein localization in organelle (GO:0072595)3.93982877
60nuclear pore complex assembly (GO:0051292)3.91397817
61cellular modified amino acid catabolic process (GO:0042219)3.88778090
62maturation of SSU-rRNA (GO:0030490)3.87335266
63regulation of translational fidelity (GO:0006450)3.87261373
64regulation of mitochondrial translation (GO:0070129)3.82991322
65mitochondrion distribution (GO:0048311)3.82758426
66cell fate commitment involved in formation of primary germ layer (GO:0060795)3.74184809
67regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.73281870
68intestinal epithelial cell development (GO:0060576)3.70665700
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.69671076
70intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.67263575
71cullin deneddylation (GO:0010388)3.67187763
72cardiovascular system development (GO:0072358)3.66328540
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.63954504
74formation of translation preinitiation complex (GO:0001731)3.60153223
75icosanoid secretion (GO:0032309)3.56583591
76arachidonic acid secretion (GO:0050482)3.56583591
77proline transport (GO:0015824)3.52479208
78bone trabecula formation (GO:0060346)3.51843627
79microtubule severing (GO:0051013)3.51432642
80protein maturation by protein folding (GO:0022417)3.51064418
81retinoic acid receptor signaling pathway (GO:0048384)3.50989819
82ribonucleoprotein complex biogenesis (GO:0022613)3.50077624
83regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.49514674
84positive regulation of protein deacetylation (GO:0090312)3.48085855
85pre-miRNA processing (GO:0031054)3.47991642
86regulation of telomerase activity (GO:0051972)3.47847092
87telomere maintenance via semi-conservative replication (GO:0032201)3.46649440
88ribosome assembly (GO:0042255)3.46625676
89negative regulation of transcription by competitive promoter binding (GO:0010944)3.46453485
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45716387
91DNA strand elongation (GO:0022616)3.44198477
92vitamin A metabolic process (GO:0006776)3.42765787
93DNA strand elongation involved in DNA replication (GO:0006271)3.41977796
94omega-hydroxylase P450 pathway (GO:0097267)3.41945672
95trophectodermal cell differentiation (GO:0001829)3.39153489
96transcription from mitochondrial promoter (GO:0006390)3.38730456
97GDP-mannose metabolic process (GO:0019673)3.38139484
98nucleoside transport (GO:0015858)3.37716359
99protein polyglutamylation (GO:0018095)3.36920983
100ncRNA 3-end processing (GO:0043628)3.36809731
101tRNA methylation (GO:0030488)3.36463275
102regulation of telomere maintenance (GO:0032204)3.36456831
103chaperone-mediated protein transport (GO:0072321)3.36068963
104nuclear pore organization (GO:0006999)3.35625573
105de novo protein folding (GO:0006458)3.35130179
106intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.33313235
107ventricular system development (GO:0021591)3.29304049
108DNA damage response, detection of DNA damage (GO:0042769)3.29166386
109ribosomal small subunit assembly (GO:0000028)3.28985372
110mitotic chromosome condensation (GO:0007076)3.27639683
111ribosomal large subunit biogenesis (GO:0042273)3.26175007
112protein complex localization (GO:0031503)3.25535549
113negative regulation of interleukin-2 production (GO:0032703)3.24866832
114DNA replication initiation (GO:0006270)3.24470374
115RNA stabilization (GO:0043489)3.21195986
116mRNA stabilization (GO:0048255)3.21195986
117regulation of microtubule-based movement (GO:0060632)3.20878810
118serine family amino acid biosynthetic process (GO:0009070)3.20853979
119regulation of posttranscriptional gene silencing (GO:0060147)3.19752153
120regulation of gene silencing by miRNA (GO:0060964)3.19752153
121regulation of gene silencing by RNA (GO:0060966)3.19752153
122viral transcription (GO:0019083)3.18131632
123protein deneddylation (GO:0000338)3.18087163
124negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.18081781
125apoptotic DNA fragmentation (GO:0006309)3.16937706
126ribosome biogenesis (GO:0042254)3.16513017
127transcription elongation from RNA polymerase III promoter (GO:0006385)3.15833069
128termination of RNA polymerase III transcription (GO:0006386)3.15833069
129negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.15244245
130maternal placenta development (GO:0001893)3.14892126
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10326714
132rRNA processing (GO:0006364)3.10103783
133de novo posttranslational protein folding (GO:0051084)3.04765192
134protein targeting to mitochondrion (GO:0006626)3.00390461
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.99494641
136translational termination (GO:0006415)2.99244523
137establishment of integrated proviral latency (GO:0075713)2.96920403
138response to redox state (GO:0051775)2.94637592
139nucleobase-containing small molecule interconversion (GO:0015949)2.94470855
140rRNA metabolic process (GO:0016072)2.93950527
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93860798
142mitochondrial RNA metabolic process (GO:0000959)2.92548680
143cellular protein complex localization (GO:0034629)2.90023760
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.89325342
145establishment of protein localization to mitochondrion (GO:0072655)2.87773516
146deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87117718
147nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86347915
148regulation of translational termination (GO:0006449)2.85611073
149protein insertion into membrane (GO:0051205)2.82803100
150protein-cofactor linkage (GO:0018065)2.82173106
151mitotic nuclear envelope reassembly (GO:0007084)2.81970220
152nuclear envelope reassembly (GO:0031468)2.81970220
153nucleotide-excision repair, DNA gap filling (GO:0006297)2.81043505
154negative regulation of RNA splicing (GO:0033119)2.80697223
155translational elongation (GO:0006414)2.79930869
156translational initiation (GO:0006413)2.77731550
157protein localization to mitochondrion (GO:0070585)2.77506330
158proline biosynthetic process (GO:0006561)2.76628275
159mitotic metaphase plate congression (GO:0007080)2.75008143
160regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.74048771
161negative regulation of mRNA processing (GO:0050686)2.72533240
162translation (GO:0006412)2.72349061
163RNA localization (GO:0006403)2.70433078
164tRNA aminoacylation for protein translation (GO:0006418)2.69587440
165transcription elongation from RNA polymerase II promoter (GO:0006368)2.69303026
166negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.68970160
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68306945
168negative regulation of microtubule depolymerization (GO:0007026)2.68121694
169positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68005802
170regulation of microtubule depolymerization (GO:0031114)2.67786874
171viral life cycle (GO:0019058)2.64246369
172amino acid activation (GO:0043038)2.64125215
173tRNA aminoacylation (GO:0043039)2.64125215
174peptidyl-arginine omega-N-methylation (GO:0035247)2.63634899
175cellular component biogenesis (GO:0044085)2.63255090
176protein targeting to ER (GO:0045047)2.62950850
177cotranslational protein targeting to membrane (GO:0006613)2.61753275
178spliceosomal tri-snRNP complex assembly (GO:0000244)2.59747527
179spliceosomal snRNP assembly (GO:0000387)2.59692141
180negative regulation of ligase activity (GO:0051352)2.59165042
181negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59165042
182negative regulation of Notch signaling pathway (GO:0045746)2.58858921
183histone arginine methylation (GO:0034969)2.58531238
184pentose metabolic process (GO:0019321)2.57453621
185layer formation in cerebral cortex (GO:0021819)2.57277489
186maturation of 5.8S rRNA (GO:0000460)2.55828582
187daunorubicin metabolic process (GO:0044597)11.6562151
188polyketide metabolic process (GO:0030638)11.6562151
189doxorubicin metabolic process (GO:0044598)11.6562151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.87488551
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.82297894
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.82297894
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.82297894
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.32783367
6E2F7_22180533_ChIP-Seq_HELA_Human3.65258347
7ZNF263_19887448_ChIP-Seq_K562_Human3.59347430
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.53398006
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.21606266
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14167074
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.08748763
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.00394815
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95534800
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84867361
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.76950756
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.68313836
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64017512
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.61197000
19XRN2_22483619_ChIP-Seq_HELA_Human2.46044432
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43739098
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.40616846
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12532272
23* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.11226485
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10365108
25* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.06027713
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03024189
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97908776
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97156061
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97076765
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.94773238
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94224985
32GABP_19822575_ChIP-Seq_HepG2_Human1.92508738
33IRF1_19129219_ChIP-ChIP_H3396_Human1.92251317
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91035508
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91023499
36DCP1A_22483619_ChIP-Seq_HELA_Human1.88236508
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85627164
38TTF2_22483619_ChIP-Seq_HELA_Human1.80105077
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79354318
40* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.78710161
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78378539
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78309319
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.76796734
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74153879
45TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.71563538
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71519632
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68576922
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67631805
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64529172
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.62555371
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61136646
52VDR_21846776_ChIP-Seq_THP-1_Human1.60886592
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.58690456
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56893273
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54833258
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.54101173
57NANOG_18692474_ChIP-Seq_MEFs_Mouse1.53675124
58* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.51694168
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.50503634
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49305056
61PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.48860491
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48393060
63* LXR_22292898_ChIP-Seq_THP-1_Human1.45034191
64* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.44861739
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42164065
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40969659
67E2F1_17053090_ChIP-ChIP_MCF-7_Human1.40916763
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38386030
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37437323
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.35137500
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34331439
72KDM5A_27292631_Chip-Seq_BREAST_Human1.34069932
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.33632598
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29612201
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29439310
76TFEB_21752829_ChIP-Seq_HELA_Human1.29357101
77NANOG_16518401_ChIP-PET_MESCs_Mouse1.27770076
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27445861
79* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27443884
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25871940
81* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25181287
82* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25125403
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25060631
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21777867
85* MYC_18555785_ChIP-Seq_MESCs_Mouse1.21283644
86CIITA_25753668_ChIP-Seq_RAJI_Human1.20174946
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19017491
88P68_20966046_ChIP-Seq_HELA_Human1.17479566
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16685396
90* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16453711
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16120468
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.15620971
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15560521
94FOXP3_21729870_ChIP-Seq_TREG_Human1.13227712
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12643126
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12527704
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12169148
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10813602
99MYC_22102868_ChIP-Seq_BL_Human1.09986783
100VDR_23849224_ChIP-Seq_CD4+_Human1.07774344
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.07634066
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07186274
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.05971904
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05843902
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.05658981
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04962023
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04933264
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04828964
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03886370
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03025565
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02816173
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.02415643
113AR_21909140_ChIP-Seq_LNCAP_Human1.02400762
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02396689
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02079014
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02055752
117ATF3_27146783_Chip-Seq_COLON_Human1.01975306
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98870754
119* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97973137
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96362129
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95861480
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95607544
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94387236
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93818897
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93483691
126* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93327918
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92681716
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92474133
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.92170395
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91607473
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90586944
132* TP53_22127205_ChIP-Seq_IMR90_Human0.88299757
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87305152
134* NCOR1_26117541_ChIP-Seq_K562_Human0.87153807
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85858532
136TCF7_22412390_ChIP-Seq_EML_Mouse0.84970364
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82831187
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82478429
139KAP1_27257070_Chip-Seq_ESCs_Mouse0.81229300
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80138864
141SMC4_20622854_ChIP-Seq_HELA_Human0.79870714
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78689416
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77885778
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77815571
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.76487130
146* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.74923836
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74611794
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.71463528
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.71282289
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70090806
151CTCF_21964334_Chip-Seq_Bcells_Human0.70029163
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.69521775
153RNF2_27304074_Chip-Seq_NSC_Mouse0.68906455
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.68655844
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.68295192
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68105265
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.68031124
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.67165932
159* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66936222
160* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66707442
161* KDM2B_26808549_Chip-Seq_K562_Human0.66192102
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.65583474
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63012263
164* RACK7_27058665_Chip-Seq_MCF-7_Human0.62485495
165E2F1_18555785_ChIP-Seq_MESCs_Mouse0.62333171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.64795307
2MP0006292_abnormal_olfactory_placode4.57595257
3MP0003011_delayed_dark_adaptation4.56841266
4MP0002254_reproductive_system_inflammat4.22975942
5MP0003693_abnormal_embryo_hatching4.20936356
6MP0003890_abnormal_embryonic-extraembry3.74683950
7MP0005394_taste/olfaction_phenotype3.63536591
8MP0005499_abnormal_olfactory_system3.63536591
9MP0004858_abnormal_nervous_system3.51292511
10MP0003122_maternal_imprinting3.26091732
11MP0005075_abnormal_melanosome_morpholog3.03958363
12MP0008057_abnormal_DNA_replication3.00982627
13MP0002332_abnormal_exercise_endurance3.00007975
14MP0004957_abnormal_blastocyst_morpholog2.59875214
15MP0002653_abnormal_ependyma_morphology2.55711447
16MP0005257_abnormal_intraocular_pressure2.54585636
17MP0008260_abnormal_autophagy2.38333117
18MP0006035_abnormal_mitochondrial_morpho2.37822904
19MP0010234_abnormal_vibrissa_follicle2.33661330
20MP0003121_genomic_imprinting2.32213640
21MP0003705_abnormal_hypodermis_morpholog2.31875585
22MP0000678_abnormal_parathyroid_gland2.26718082
23MP0005501_abnormal_skin_physiology2.26555941
24MP0010352_gastrointestinal_tract_polyps2.25071796
25MP0001188_hyperpigmentation2.15848997
26MP0009840_abnormal_foam_cell2.06178603
27MP0005058_abnormal_lysosome_morphology2.00466164
28MP0002796_impaired_skin_barrier2.00401636
29MP0000537_abnormal_urethra_morphology1.99169425
30MP0003186_abnormal_redox_activity1.96558502
31MP0003938_abnormal_ear_development1.93349228
32MP0009379_abnormal_foot_pigmentation1.88065752
33MP0002277_abnormal_respiratory_mucosa1.87802169
34MP0005451_abnormal_body_composition1.83729453
35MP0010030_abnormal_orbit_morphology1.82742907
36MP0008961_abnormal_basal_metabolism1.82267684
37MP0001672_abnormal_embryogenesis/_devel1.78545576
38MP0005380_embryogenesis_phenotype1.78545576
39MP0004233_abnormal_muscle_weight1.78441977
40MP0003183_abnormal_peptide_metabolism1.76751920
41MP0002127_abnormal_cardiovascular_syste1.71928008
42MP0003786_premature_aging1.71416307
43MP0002088_abnormal_embryonic_growth/wei1.65635749
44MP0001986_abnormal_taste_sensitivity1.63732349
45MP0003984_embryonic_growth_retardation1.63309648
46MP0004185_abnormal_adipocyte_glucose1.61007190
47MP0002089_abnormal_postnatal_growth/wei1.58695528
48MP0008058_abnormal_DNA_repair1.56790558
49MP0001293_anophthalmia1.54173219
50MP0002932_abnormal_joint_morphology1.52643225
51MP0000762_abnormal_tongue_morphology1.50599042
52MP0005423_abnormal_somatic_nervous1.50365788
53MP0000049_abnormal_middle_ear1.49898766
54MP0000003_abnormal_adipose_tissue1.49064765
55MP0006082_CNS_inflammation1.48362285
56MP0001849_ear_inflammation1.45118814
57MP0000681_abnormal_thyroid_gland1.42619738
58MP0008789_abnormal_olfactory_epithelium1.41126122
59MP0000013_abnormal_adipose_tissue1.38157829
60MP0003123_paternal_imprinting1.37546965
61MP0001661_extended_life_span1.36598804
62MP0005266_abnormal_metabolism1.35669094
63MP0002092_abnormal_eye_morphology1.35499122
64MP0000350_abnormal_cell_proliferation1.32641730
65MP0004043_abnormal_pH_regulation1.32510473
66MP0000462_abnormal_digestive_system1.32267387
67MP0001348_abnormal_lacrimal_gland1.32173498
68MP0002160_abnormal_reproductive_system1.30701527
69MP0009672_abnormal_birth_weight1.30190780
70MP0002085_abnormal_embryonic_tissue1.25312092
71MP0002233_abnormal_nose_morphology1.25098348
72MP0002086_abnormal_extraembryonic_tissu1.24777748
73MP0003941_abnormal_skin_development1.21874797
74MP0009780_abnormal_chondrocyte_physiolo1.16868858
75MP0002114_abnormal_axial_skeleton1.15144645
76MP0003077_abnormal_cell_cycle1.13094498
77MP0009333_abnormal_splenocyte_physiolog1.11946438
78MP0003329_amyloid_beta_deposits1.10416270
79MP0004133_heterotaxia1.08545019
80MP0003755_abnormal_palate_morphology1.08060851
81MP0003385_abnormal_body_wall1.07517137
82MP0003119_abnormal_digestive_system1.07357470
83MP0001727_abnormal_embryo_implantation1.07085165
84MP0002084_abnormal_developmental_patter1.05851787
85MP0003283_abnormal_digestive_organ1.05021870
86MP0002970_abnormal_white_adipose1.04553376
87MP0003935_abnormal_craniofacial_develop1.04113866
88MP0000432_abnormal_head_morphology1.03611573
89MP0003137_abnormal_impulse_conducting1.03453932
90MP0000428_abnormal_craniofacial_morphol1.03039535
91MP0009053_abnormal_anal_canal1.01529158
92MP0002177_abnormal_outer_ear0.96478204
93MP0005248_abnormal_Harderian_gland0.96404944
94MP0002396_abnormal_hematopoietic_system0.96132421
95MP0003718_maternal_effect0.95987516
96MP0008770_decreased_survivor_rate0.93658123
97MP0004197_abnormal_fetal_growth/weight/0.92739669
98MP0005508_abnormal_skeleton_morphology0.90672082
99MP0003879_abnormal_hair_cell0.90559814
100MP0005076_abnormal_cell_differentiation0.89126511
101MP0004381_abnormal_hair_follicle0.87438634
102MP0000377_abnormal_hair_follicle0.87150091
103MP0005391_vision/eye_phenotype0.86560739
104MP0003787_abnormal_imprinting0.85187682
105MP0003111_abnormal_nucleus_morphology0.84532015
106MP0002751_abnormal_autonomic_nervous0.83842771
107MP0003315_abnormal_perineum_morphology0.81760011
108MP0003806_abnormal_nucleotide_metabolis0.81245180
109MP0000313_abnormal_cell_death0.81210231
110MP0002925_abnormal_cardiovascular_devel0.80494032
111MP0001881_abnormal_mammary_gland0.80474764
112MP0002210_abnormal_sex_determination0.80230023
113MP0002163_abnormal_gland_morphology0.79725683
114MP0002116_abnormal_craniofacial_bone0.79549428
115MP0000516_abnormal_urinary_system0.79083689
116MP0005367_renal/urinary_system_phenotyp0.79083689
117MP0001730_embryonic_growth_arrest0.78432042
118MP0003566_abnormal_cell_adhesion0.76741208
119MP0001697_abnormal_embryo_size0.76483153
120MP0000749_muscle_degeneration0.75480502
121MP0002249_abnormal_larynx_morphology0.75457289
122MP0002269_muscular_atrophy0.74611066
123MP0003453_abnormal_keratinocyte_physiol0.74231033
124MP0002080_prenatal_lethality0.73609827
125MP0000750_abnormal_muscle_regeneration0.73444551
126MP0005375_adipose_tissue_phenotype0.73328138
127MP0005623_abnormal_meninges_morphology0.73141538
128MP0005083_abnormal_biliary_tract0.72078392
129MP0003937_abnormal_limbs/digits/tail_de0.71844533
130MP0008932_abnormal_embryonic_tissue0.71694284
131MP0002132_abnormal_respiratory_system0.71649764
132MP0010771_integument_phenotype0.70657750
133MP0000490_abnormal_crypts_of0.69759670
134MP0009703_decreased_birth_body0.67744825
135MP0002697_abnormal_eye_size0.66819039
136MP0010307_abnormal_tumor_latency0.66711741
137MP0010094_abnormal_chromosome_stability0.66022188
138MP0001286_abnormal_eye_development0.64314028
139MP0005023_abnormal_wound_healing0.63232435
140MP0002098_abnormal_vibrissa_morphology0.63134487
141MP0002081_perinatal_lethality0.62303654
142MP0000358_abnormal_cell_content/0.61482433
143MP0004883_abnormal_blood_vessel0.58657668
144MP0003828_pulmonary_edema0.56805872
145MP0008872_abnormal_physiological_respon0.56652202
146MP0003861_abnormal_nervous_system0.55600586
147MP0002111_abnormal_tail_morphology0.53600916
148MP0004272_abnormal_basement_membrane0.50496704
149MP0002877_abnormal_melanocyte_morpholog0.49869532
150MP0008007_abnormal_cellular_replicative0.48870980
151MP0006036_abnormal_mitochondrial_physio0.47955998

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.75176975
2Hypochromic microcytic anemia (HP:0004840)5.98946107
3Hepatoblastoma (HP:0002884)5.36880681
4Abnormality of the lower motor neuron (HP:0002366)5.23227619
5Multiple enchondromatosis (HP:0005701)5.11935597
6Rib fusion (HP:0000902)5.06319405
7Deep palmar crease (HP:0006191)4.97771033
8Facial cleft (HP:0002006)4.67951481
9Microvesicular hepatic steatosis (HP:0001414)4.46545360
10Ependymoma (HP:0002888)4.35228425
11Rectovaginal fistula (HP:0000143)3.79334848
12Rectal fistula (HP:0100590)3.79334848
13Neoplasm of striated muscle (HP:0009728)3.78323747
14Partial duplication of thumb phalanx (HP:0009944)3.66367792
15Nephroblastoma (Wilms tumor) (HP:0002667)3.59300932
16Rhabdomyosarcoma (HP:0002859)3.56825270
17Hypoplasia of the fovea (HP:0007750)3.53910023
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.53910023
19Bifid tongue (HP:0010297)3.49361951
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49093896
21Intestinal fistula (HP:0100819)3.40555928
22Fused cervical vertebrae (HP:0002949)3.37008759
23Embryonal renal neoplasm (HP:0011794)3.33690975
24Testicular atrophy (HP:0000029)3.33425891
25Vaginal fistula (HP:0004320)3.29469765
26Vertebral compression fractures (HP:0002953)3.29203361
27Abnormality of the aortic arch (HP:0012303)3.28759491
28Partial duplication of the phalanx of hand (HP:0009999)3.21067490
29Hyperacusis (HP:0010780)3.19502522
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.18640945
31Abnormality of the astrocytes (HP:0100707)3.17699846
32Astrocytoma (HP:0009592)3.17699846
33Amyotrophic lateral sclerosis (HP:0007354)3.12146770
34Hyperinsulinemic hypoglycemia (HP:0000825)3.10998714
35Abnormality of the salivary glands (HP:0010286)3.10739606
36Aplasia/hypoplasia of the humerus (HP:0006507)3.07753268
37Short humerus (HP:0005792)3.05480742
38Ragged-red muscle fibers (HP:0003200)3.03731746
39Anomalous pulmonary venous return (HP:0010772)3.03271970
40Abnormality of cells of the erythroid lineage (HP:0012130)2.99047314
41Chromsome breakage (HP:0040012)2.91513236
42Insomnia (HP:0100785)2.90976560
43Abnormal lung lobation (HP:0002101)2.90154347
44Reticulocytopenia (HP:0001896)2.86857322
45Long palpebral fissure (HP:0000637)2.86807658
46Abnormal cartilage morphology (HP:0002763)2.77857843
47Hyperventilation (HP:0002883)2.77631253
48Overriding aorta (HP:0002623)2.75811742
49Trismus (HP:0000211)2.72965369
50Abnormal number of erythroid precursors (HP:0012131)2.72901263
51Rough bone trabeculation (HP:0100670)2.71886742
52Generalized hypotonia (HP:0001290)2.71539468
53Abnormality of the fovea (HP:0000493)2.67245069
54Abnormality of the phalanges of the hallux (HP:0010057)2.66271202
55Preauricular pit (HP:0004467)2.61212248
56Periauricular skin pits (HP:0100277)2.61212248
57Preauricular skin tag (HP:0000384)2.59854474
58Abnormality of the pulmonary veins (HP:0011718)2.57115162
59Reduced antithrombin III activity (HP:0001976)2.54206280
60Cerebral inclusion bodies (HP:0100314)2.54038497
61Horizontal nystagmus (HP:0000666)2.53182699
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51733992
63Progressive external ophthalmoplegia (HP:0000590)2.44085465
64Large earlobe (HP:0009748)2.43801218
65Diminished motivation (HP:0000745)2.40921575
66Athetosis (HP:0002305)2.40059050
67Hypochromic anemia (HP:0001931)2.40033880
68Sensory axonal neuropathy (HP:0003390)2.39579335
69Abnormality of glycolysis (HP:0004366)2.39393230
70Shawl scrotum (HP:0000049)2.39021512
71Tetraplegia (HP:0002445)2.37208164
72Hypokinesia (HP:0002375)2.36734246
73Impulsivity (HP:0100710)2.34183806
74Elfin facies (HP:0004428)2.33963502
75Abnormality of the pubic bones (HP:0003172)2.33849070
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.32626875
77Abnormality of chromosome segregation (HP:0002916)2.32177234
78Abnormal trabecular bone morphology (HP:0100671)2.32012882
79Short 5th finger (HP:0009237)2.32012673
80Nasolacrimal duct obstruction (HP:0000579)2.31789848
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31726616
82Aplasia/Hypoplasia of the macula (HP:0008059)2.31357787
83Glioma (HP:0009733)2.30456985
84Neoplasm of the heart (HP:0100544)2.28132504
85Skin tags (HP:0010609)2.28022013
86Difficulty running (HP:0009046)2.27579017
87Progressive muscle weakness (HP:0003323)2.26100887
88Hypopigmentation of the fundus (HP:0007894)2.25382352
89Selective tooth agenesis (HP:0001592)2.23443973
90Abnormality of the musculature of the hand (HP:0001421)2.22896837
91Large eyes (HP:0001090)2.22847996
92Apathy (HP:0000741)2.22825366
93Meckel diverticulum (HP:0002245)2.22362218
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.20883167
95Supernumerary spleens (HP:0009799)2.20810502
96Increased connective tissue (HP:0009025)2.19466030
97Birth length less than 3rd percentile (HP:0003561)2.17840200
98Tongue fasciculations (HP:0001308)2.17420567
99Upper motor neuron abnormality (HP:0002127)2.16883433
100Atresia of the external auditory canal (HP:0000413)2.15003424
101Macrocytic anemia (HP:0001972)2.14142159
102Villous atrophy (HP:0011473)2.13442036
103Abnormality of small intestinal villus morphology (HP:0011472)2.13442036
104Abnormality of glycolipid metabolism (HP:0010969)2.13428079
105Abnormality of liposaccharide metabolism (HP:0010968)2.13428079
106Abnormality of glycosphingolipid metabolism (HP:0004343)2.13428079
107Ureteral duplication (HP:0000073)2.12334192
108Renal duplication (HP:0000075)2.12257788
109Abnormality of the umbilical cord (HP:0010881)2.10933319
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10703526
111Increased serum lactate (HP:0002151)2.10108044
112Abnormality of the ileum (HP:0001549)2.09825428
113Hand muscle atrophy (HP:0009130)2.08838121
114Hypergonadotropic hypogonadism (HP:0000815)2.07852271
115Microretrognathia (HP:0000308)2.07392999
116Abnormal umbilical cord blood vessels (HP:0011403)2.07165705
117Single umbilical artery (HP:0001195)2.07165705
118Abnormality of the fetal cardiovascular system (HP:0010948)2.07165705
119Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07048973
120Skin pits (HP:0100276)2.06157222
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05739694
122Malignant neoplasm of the central nervous system (HP:0100836)2.05352822
123Hyperparathyroidism (HP:0000843)2.05300012
124Limb hypertonia (HP:0002509)2.04622165
125Pseudobulbar signs (HP:0002200)2.03537221
126Hepatocellular necrosis (HP:0001404)2.03085967
127Cheilitis (HP:0100825)2.02249439
128Aplasia/Hypoplasia of the sternum (HP:0006714)2.02244477
129Breast hypoplasia (HP:0003187)2.01014848
130Vertebral fusion (HP:0002948)2.00144733
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00008496
132Hypercalcemia (HP:0003072)1.99444288
133Broad distal phalanx of finger (HP:0009836)1.99430894
134Hypercortisolism (HP:0001578)1.99190467
135Capillary hemangiomas (HP:0005306)1.97971393
136Increased serum pyruvate (HP:0003542)1.97161725
137Muscle fibrillation (HP:0010546)1.96440648
138Facial hemangioma (HP:0000329)1.95958012
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95726005
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.94995545
141Hypoplastic scapulae (HP:0000882)1.94750850
142Aplasia/Hypoplasia of the scapulae (HP:0006713)1.94750850
143Duplication of thumb phalanx (HP:0009942)1.93742102
144Glossoptosis (HP:0000162)1.92695266
145Upper limb muscle weakness (HP:0003484)1.92195504
146Progressive hearing impairment (HP:0001730)1.91591071
147Patent foramen ovale (HP:0001655)1.90057730
148Sparse eyelashes (HP:0000653)1.90012489
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89209187
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89209187
151Congenital malformation of the right heart (HP:0011723)1.89109238
152Double outlet right ventricle (HP:0001719)1.89109238
153Abnormality of the intrinsic pathway (HP:0010989)1.88985538
154Spastic paraparesis (HP:0002313)1.88404488
155Prominent occiput (HP:0000269)1.87990587
156Supernumerary nipples (HP:0002558)1.87986748
157Achilles tendon contracture (HP:0001771)1.87323068
158Amblyopia (HP:0000646)1.87001298
159Deviation of the thumb (HP:0009603)1.86974239
160Ankle contracture (HP:0006466)1.86762516
161Truncus arteriosus (HP:0001660)1.86321624
162Aplasia cutis congenita (HP:0001057)1.84216924
163Proximal placement of thumb (HP:0009623)1.83219089
164Acute encephalopathy (HP:0006846)1.80721577
165Abnormal mitochondria in muscle tissue (HP:0008316)1.77372394
166Septate vagina (HP:0001153)1.75138441
167Abnormal number of incisors (HP:0011064)1.74702906
168Hepatic necrosis (HP:0002605)1.72281627
169High anterior hairline (HP:0009890)1.71010627
170Paraparesis (HP:0002385)1.70402283
171Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68811678
172Squamous cell carcinoma (HP:0002860)1.67989879
173Abnormality of the motor neurons (HP:0002450)1.65601384
174Abnormal neuron morphology (HP:0012757)1.65601384
175Increased CSF lactate (HP:0002490)1.64525689
176Lactic acidosis (HP:0003128)1.63285978
177Hyperthyroidism (HP:0000836)1.63178577
178Male infertility (HP:0003251)1.63150582
179Abnormalities of placenta or umbilical cord (HP:0001194)1.63142286
180Elbow flexion contracture (HP:0002987)1.61297430
181Knee flexion contracture (HP:0006380)1.58681072
182Pancytopenia (HP:0001876)1.57767600
183Increased nuchal translucency (HP:0010880)1.57662145
184Lipid accumulation in hepatocytes (HP:0006561)1.56892212
185Pili torti (HP:0003777)1.56610758
186Abnormality of the thoracic spine (HP:0100711)1.56461341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.29060308
2GRK55.86129421
3GRK64.72851456
4ERN14.40416661
5NME24.15024481
6ADRBK23.59471310
7GRK13.56169421
8TESK22.96497593
9CSF1R2.93249511
10TYRO32.75133171
11TESK12.64091510
12SMG12.63975892
13TGFBR22.63572967
14PDK22.54981561
15GRK72.52880285
16IRAK32.46818446
17MST1R2.39390758
18TTK2.39292295
19LIMK12.36089590
20TRIB32.34851183
21MAPK72.34592142
22VRK22.25689367
23MATK2.15530610
24STK102.08954249
25WNK12.06507965
26MOS2.05409720
27SRPK11.94713492
28MARK11.93494170
29EEF2K1.81661652
30PBK1.77087326
31TSSK61.59727544
32PIM21.59189346
33CAMK41.56019602
34PRKG21.54754745
35CDK71.49269458
36ABL21.49240584
37RPS6KA41.46383812
38NTRK11.41216373
39CDK81.40341298
40BRAF1.36708243
41MARK21.30856198
42AKT31.29354130
43STK161.27708011
44EPHA21.27705076
45BCKDK1.23092984
46PAK41.21906455
47ADRBK11.21884943
48MAP3K81.12538115
49HIPK21.12016711
50CHEK21.11809863
51MAP2K41.10590142
52MET1.10541576
53MAP3K101.09538893
54STK41.01115205
55BRSK10.99610213
56FGFR30.98516325
57PLK10.98514914
58LMTK20.96724241
59ATR0.95988883
60TLK10.94931685
61CDK190.89247482
62LATS20.85011887
63CSNK1G30.84995133
64ERBB40.84963833
65ALK0.83903531
66CDK90.80815719
67KDR0.80143974
68EPHB20.79336095
69DAPK30.78212860
70SCYL20.77392249
71MAP2K60.75399818
72AKT20.74630848
73CSK0.74583533
74PKN20.73790964
75ILK0.73316842
76NME10.72486999
77CHEK10.68028732
78MAP3K70.67991992
79MAP2K20.66091265
80MAP2K70.65832427
81ZAK0.64858353
82CSNK1G10.64381466
83EIF2AK10.63313300
84MAPK120.62829615
85CSNK1A1L0.62450027
86CSNK2A10.62446771
87DAPK10.62394205
88RPS6KA50.58941878
89ARAF0.58526566
90EIF2AK20.57190137
91CAMK2G0.56735693
92MAP3K90.56587547
93CSNK2A20.53868682
94PLK30.52585287
95CSNK1G20.52024703
96PRKD30.50783257
97MTOR0.50336521
98PLK40.47345777
99CAMK2B0.47304522
100MAPK110.47294070
101CAMK2D0.45845417
102IRAK20.45331858
103PRKCI0.42941004
104IGF1R0.41267885
105CDK20.40653037
106PTK20.39872938
107AURKA0.37024955
108RPS6KB20.35555560
109CDC70.35000246
110PDGFRA0.34850345
111NEK20.34590785
112PRKCD0.32671923
113STK380.31032579
114ICK0.30642481
115CSNK1E0.30331823
116PRKD20.28947932
117BMX0.28736800
118MAPK100.28277093
119DDR20.28172692
120RIPK10.27472466
121ERBB20.26825631
122PAK10.26586168
123ATM0.26485798
124CDK40.25917837
125DYRK20.25808302
126ITK0.24883580
127IKBKB0.23352657
128INSR0.22681325
129CDK150.21625398
130CDK10.21201963
131PRKACG0.19744558
132NEK10.19659366
133GSK3B0.19559637
134AURKB0.19529367
135PRPF4B0.19132709
136DYRK1A0.19033327
137CDK11A0.18782911
138MAPK10.18371397
139CDK180.18274504
140PAK30.17789751
141PRKCG0.17670078
142GSK3A0.17288668
143PRKAA10.17212299
144MAPK140.16911520
145PRKACB0.16233661
146WEE10.16036278
147PAK60.15850744
148MAPK40.15187085
149NTRK20.15045263
150MAPKAPK30.14052989
151BUB10.12718698
152DYRK1B0.12675291
153PRKACA0.12554658
154RPS6KA30.11926598
155DYRK30.10911349
156SIK10.10511411
157CDK140.10235048
158TAOK10.09780608
159TAOK20.08737782
160SIK20.07708536

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.20659963
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.93113855
3Fructose and mannose metabolism_Homo sapiens_hsa000514.14575238
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16416099
5Galactose metabolism_Homo sapiens_hsa000522.88082920
6Arachidonic acid metabolism_Homo sapiens_hsa005902.82019648
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.63430717
8Proteasome_Homo sapiens_hsa030502.58919412
9RNA polymerase_Homo sapiens_hsa030202.39995075
10Linoleic acid metabolism_Homo sapiens_hsa005912.21328530
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08941763
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01995103
13Oxidative phosphorylation_Homo sapiens_hsa001901.92839461
14Vibrio cholerae infection_Homo sapiens_hsa051101.88274165
15Pyrimidine metabolism_Homo sapiens_hsa002401.87696425
16Sulfur metabolism_Homo sapiens_hsa009201.85204463
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81971325
18mTOR signaling pathway_Homo sapiens_hsa041501.71807772
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68978689
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62076858
21Parkinsons disease_Homo sapiens_hsa050121.57068682
22Thyroid cancer_Homo sapiens_hsa052161.52376061
23Nucleotide excision repair_Homo sapiens_hsa034201.44585577
24Selenocompound metabolism_Homo sapiens_hsa004501.43037558
25Huntingtons disease_Homo sapiens_hsa050161.36730974
26mRNA surveillance pathway_Homo sapiens_hsa030151.29202975
27Synaptic vesicle cycle_Homo sapiens_hsa047211.26935063
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24882302
29Fanconi anemia pathway_Homo sapiens_hsa034601.19755333
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17518921
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16100910
32Chemical carcinogenesis_Homo sapiens_hsa052041.10806765
33* RNA transport_Homo sapiens_hsa030131.09352180
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.09234472
35N-Glycan biosynthesis_Homo sapiens_hsa005101.09069578
36Ovarian steroidogenesis_Homo sapiens_hsa049131.08002630
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06591764
38Cardiac muscle contraction_Homo sapiens_hsa042601.06124912
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.05611996
40Other glycan degradation_Homo sapiens_hsa005111.04734713
41Alzheimers disease_Homo sapiens_hsa050101.03448611
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02007507
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01908065
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00282554
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98601981
46Inositol phosphate metabolism_Homo sapiens_hsa005620.97894507
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97687737
48One carbon pool by folate_Homo sapiens_hsa006700.96449996
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96274580
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96259218
51Purine metabolism_Homo sapiens_hsa002300.94715967
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.93835047
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93188149
54Ether lipid metabolism_Homo sapiens_hsa005650.91040886
55Basal cell carcinoma_Homo sapiens_hsa052170.90697499
56Cell cycle_Homo sapiens_hsa041100.90196522
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89960250
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89609028
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87887825
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.86932972
61Hedgehog signaling pathway_Homo sapiens_hsa043400.85581148
62Glutathione metabolism_Homo sapiens_hsa004800.84685730
63Oocyte meiosis_Homo sapiens_hsa041140.83088167
64RNA degradation_Homo sapiens_hsa030180.82422652
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.81798845
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81603284
67Fatty acid elongation_Homo sapiens_hsa000620.80030931
68Choline metabolism in cancer_Homo sapiens_hsa052310.77431353
69Pyruvate metabolism_Homo sapiens_hsa006200.77247043
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76583878
71Pathways in cancer_Homo sapiens_hsa052000.75364981
72DNA replication_Homo sapiens_hsa030300.73767969
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73741316
74Tryptophan metabolism_Homo sapiens_hsa003800.73191556
75Lysosome_Homo sapiens_hsa041420.71994864
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71817183
77Steroid biosynthesis_Homo sapiens_hsa001000.71271125
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70619179
79Collecting duct acid secretion_Homo sapiens_hsa049660.70356597
80Shigellosis_Homo sapiens_hsa051310.70076575
81Mismatch repair_Homo sapiens_hsa034300.69848965
82Rap1 signaling pathway_Homo sapiens_hsa040150.69367450
83Pentose phosphate pathway_Homo sapiens_hsa000300.68223483
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68082002
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67662345
86MicroRNAs in cancer_Homo sapiens_hsa052060.64877907
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64392629
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64198519
89African trypanosomiasis_Homo sapiens_hsa051430.63221767
90Homologous recombination_Homo sapiens_hsa034400.62877180
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62703164
92Acute myeloid leukemia_Homo sapiens_hsa052210.62626254
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62500394
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62200851
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60996623
96Ribosome_Homo sapiens_hsa030100.60753993
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60112597
98Hippo signaling pathway_Homo sapiens_hsa043900.59568576
99p53 signaling pathway_Homo sapiens_hsa041150.59415442
100Sulfur relay system_Homo sapiens_hsa041220.58207668
101Taste transduction_Homo sapiens_hsa047420.58102847
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.57807466
103Folate biosynthesis_Homo sapiens_hsa007900.56646284
104Metabolic pathways_Homo sapiens_hsa011000.54570291
105Non-small cell lung cancer_Homo sapiens_hsa052230.51139594
106Bladder cancer_Homo sapiens_hsa052190.50098138
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49915321
108Epstein-Barr virus infection_Homo sapiens_hsa051690.48554010
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48036330
110Carbon metabolism_Homo sapiens_hsa012000.47427801
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.46610807
112Spliceosome_Homo sapiens_hsa030400.45593468
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45096820
114Biosynthesis of amino acids_Homo sapiens_hsa012300.43793520
115AMPK signaling pathway_Homo sapiens_hsa041520.43580902
116Wnt signaling pathway_Homo sapiens_hsa043100.40779645
117Complement and coagulation cascades_Homo sapiens_hsa046100.40095480
118Non-homologous end-joining_Homo sapiens_hsa034500.39426788
119Renal cell carcinoma_Homo sapiens_hsa052110.39024284
120Arginine biosynthesis_Homo sapiens_hsa002200.38962929
121Notch signaling pathway_Homo sapiens_hsa043300.38078980
122VEGF signaling pathway_Homo sapiens_hsa043700.35694878
123Tight junction_Homo sapiens_hsa045300.33386714
124Serotonergic synapse_Homo sapiens_hsa047260.33178561
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33153204
126Proteoglycans in cancer_Homo sapiens_hsa052050.32675946
127Ras signaling pathway_Homo sapiens_hsa040140.32190795
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32099384
129Arginine and proline metabolism_Homo sapiens_hsa003300.31764571
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31524508
131Viral carcinogenesis_Homo sapiens_hsa052030.31138611
132Chronic myeloid leukemia_Homo sapiens_hsa052200.31105048
133Base excision repair_Homo sapiens_hsa034100.29726780
134Regulation of autophagy_Homo sapiens_hsa041400.29613333
135GABAergic synapse_Homo sapiens_hsa047270.28956782
136Glutamatergic synapse_Homo sapiens_hsa047240.28671721
137Long-term depression_Homo sapiens_hsa047300.28017416
138Protein export_Homo sapiens_hsa030600.27993585
139Herpes simplex infection_Homo sapiens_hsa051680.27575268
140Prion diseases_Homo sapiens_hsa050200.26310866
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.25508388
142GnRH signaling pathway_Homo sapiens_hsa049120.24533767
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.24112189
144Small cell lung cancer_Homo sapiens_hsa052220.23922510
145Insulin signaling pathway_Homo sapiens_hsa049100.23723207
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22972611
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22803930
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.21362984
149Basal transcription factors_Homo sapiens_hsa030220.19615902
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19558410
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19183944
152Adherens junction_Homo sapiens_hsa045200.19104535
153Pancreatic cancer_Homo sapiens_hsa052120.18497556
154Apoptosis_Homo sapiens_hsa042100.17127594

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