RPP25L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.12550456
2DNA deamination (GO:0045006)5.77920345
3viral transcription (GO:0019083)5.18506741
4translational termination (GO:0006415)5.01715836
5maturation of SSU-rRNA (GO:0030490)5.00483144
6chaperone-mediated protein transport (GO:0072321)4.91188867
7proteasome assembly (GO:0043248)4.85777396
8ribosomal small subunit biogenesis (GO:0042274)4.77078760
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.77057166
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.76810481
11oxidative phosphorylation (GO:0006119)4.73676088
12ribosomal large subunit biogenesis (GO:0042273)4.67575762
13respiratory electron transport chain (GO:0022904)4.63983112
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57135071
15translational elongation (GO:0006414)4.55218700
16electron transport chain (GO:0022900)4.52110851
17cotranslational protein targeting to membrane (GO:0006613)4.49128220
18protein targeting to ER (GO:0045047)4.44452782
19telomere maintenance via semi-conservative replication (GO:0032201)4.41517577
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.36303927
21DNA strand elongation involved in DNA replication (GO:0006271)4.33340125
22formation of translation preinitiation complex (GO:0001731)4.25068010
23protein localization to endoplasmic reticulum (GO:0070972)4.21726061
24translational initiation (GO:0006413)4.21603331
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.19650550
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.16228217
27protein complex biogenesis (GO:0070271)4.10514380
28DNA strand elongation (GO:0022616)4.09432582
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.03743925
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.03486086
31ribonucleoprotein complex biogenesis (GO:0022613)4.02696655
32negative regulation of ligase activity (GO:0051352)4.00727985
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.00727985
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00600837
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95780726
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.95107711
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.95107711
38protein targeting to mitochondrion (GO:0006626)3.94908215
39mitochondrial respiratory chain complex assembly (GO:0033108)3.92467221
40regulation of cellular amino acid metabolic process (GO:0006521)3.92307492
417-methylguanosine mRNA capping (GO:0006370)3.92127835
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.92111652
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.92111652
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.92111652
45cellular protein complex disassembly (GO:0043624)3.92088372
46translation (GO:0006412)3.92034273
47telomere maintenance via recombination (GO:0000722)3.90768004
48viral life cycle (GO:0019058)3.90248380
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90009929
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.87967455
51rRNA modification (GO:0000154)3.86634290
52RNA capping (GO:0036260)3.85741748
537-methylguanosine RNA capping (GO:0009452)3.85741748
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.82972766
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.82972766
56termination of RNA polymerase III transcription (GO:0006386)3.79472964
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.79472964
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.79429563
59regulation of mitochondrial translation (GO:0070129)3.77030372
60transcription-coupled nucleotide-excision repair (GO:0006283)3.75909206
61ubiquinone biosynthetic process (GO:0006744)3.75715784
62nucleobase biosynthetic process (GO:0046112)3.71312290
63establishment of protein localization to mitochondrion (GO:0072655)3.70306471
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70243423
65base-excision repair, AP site formation (GO:0006285)3.70189674
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.69830417
67DNA replication initiation (GO:0006270)3.69275907
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.67737986
69purine nucleobase biosynthetic process (GO:0009113)3.63657311
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.61511503
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60351387
72ATP synthesis coupled proton transport (GO:0015986)3.60351387
73rRNA processing (GO:0006364)3.59890098
74pseudouridine synthesis (GO:0001522)3.59873626
75spliceosomal snRNP assembly (GO:0000387)3.58557540
76protein localization to mitochondrion (GO:0070585)3.58305950
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.55182553
78ribosome biogenesis (GO:0042254)3.54155498
79NADH metabolic process (GO:0006734)3.52943720
80cullin deneddylation (GO:0010388)3.52683405
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52317186
82protein deneddylation (GO:0000338)3.51154741
83cellular component biogenesis (GO:0044085)3.50329046
84telomere maintenance via telomere lengthening (GO:0010833)3.48623038
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47892136
86rRNA metabolic process (GO:0016072)3.46752002
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46598823
88protein complex disassembly (GO:0043241)3.45367460
89mitotic recombination (GO:0006312)3.42236604
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.41804640
91ATP biosynthetic process (GO:0006754)3.40899065
92metallo-sulfur cluster assembly (GO:0031163)3.39992436
93iron-sulfur cluster assembly (GO:0016226)3.39992436
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.39866880
95cytochrome complex assembly (GO:0017004)3.39042349
96ubiquinone metabolic process (GO:0006743)3.36545354
97pyrimidine nucleotide catabolic process (GO:0006244)3.35225070
98deoxyribose phosphate catabolic process (GO:0046386)3.34108740
99deoxyribonucleotide catabolic process (GO:0009264)3.34092858
100termination of RNA polymerase I transcription (GO:0006363)3.34028378
101positive regulation of ligase activity (GO:0051351)3.33403964
102DNA replication checkpoint (GO:0000076)3.32216291
103macromolecular complex disassembly (GO:0032984)3.30192440
104mitochondrial transport (GO:0006839)3.29992765
105purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28968232
106peptidyl-arginine omega-N-methylation (GO:0035247)3.28811244
107purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28183267
108peptidyl-histidine modification (GO:0018202)3.26289033
109positive regulation of cell cycle arrest (GO:0071158)3.23671161
110quinone biosynthetic process (GO:1901663)3.20626695
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.19691328
112establishment of integrated proviral latency (GO:0075713)3.17494740
113nuclear-transcribed mRNA catabolic process (GO:0000956)3.16529748
114rRNA methylation (GO:0031167)3.16068664
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15142172
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15142172
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14694679
118CENP-A containing nucleosome assembly (GO:0034080)3.14511620
119regulation of ubiquitin-protein transferase activity (GO:0051438)3.13200686
120respiratory chain complex IV assembly (GO:0008535)3.12599573
121ribonucleoside triphosphate biosynthetic process (GO:0009201)3.12402832
122transcription from RNA polymerase I promoter (GO:0006360)3.10763908
123GTP biosynthetic process (GO:0006183)3.10541094
124guanosine-containing compound biosynthetic process (GO:1901070)3.09200527
125G1/S transition of mitotic cell cycle (GO:0000082)3.08738018
126cell cycle G1/S phase transition (GO:0044843)3.08738018
127transcription elongation from RNA polymerase I promoter (GO:0006362)3.07892689
128tRNA methylation (GO:0030488)3.05301104
129L-methionine salvage (GO:0071267)3.05182222
130L-methionine biosynthetic process (GO:0071265)3.05182222
131amino acid salvage (GO:0043102)3.05182222
132purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.04883659
133purine nucleoside monophosphate biosynthetic process (GO:0009127)3.04883659
134regulation of ligase activity (GO:0051340)3.03572888
135NADH dehydrogenase complex assembly (GO:0010257)3.00709322
136mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00709322
137tricarboxylic acid cycle (GO:0006099)2.99980615
138deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99808515
139protein neddylation (GO:0045116)2.99130656
140purine deoxyribonucleotide catabolic process (GO:0009155)2.98053234
141inner mitochondrial membrane organization (GO:0007007)2.93885838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52497479
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35325861
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.33064355
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99434571
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.83607554
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82396715
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.70723484
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.44987264
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.19519043
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19027589
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11589651
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05571214
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84985120
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83504942
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83301892
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66962049
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59604912
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56486900
19VDR_23849224_ChIP-Seq_CD4+_Human2.52327820
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51446481
21XRN2_22483619_ChIP-Seq_HELA_Human2.48214888
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44670095
23DCP1A_22483619_ChIP-Seq_HELA_Human2.39382797
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36556634
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34623720
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29278062
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24204080
28FOXP3_21729870_ChIP-Seq_TREG_Human2.21434099
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.14874169
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.10390255
31GABP_19822575_ChIP-Seq_HepG2_Human2.10058393
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08273218
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03371711
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00912868
35TTF2_22483619_ChIP-Seq_HELA_Human1.90245759
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88189791
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81111637
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81026130
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.79116649
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72295032
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72236082
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71864999
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71299313
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68973579
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66818381
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63690859
47ELK1_19687146_ChIP-ChIP_HELA_Human1.61865827
48CIITA_25753668_ChIP-Seq_RAJI_Human1.58858933
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57926703
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57249152
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51451084
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51368438
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48634922
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47611570
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46730754
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42785254
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39161604
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39013822
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38116656
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32910288
61AR_21909140_ChIP-Seq_LNCAP_Human1.31142115
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.27711548
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.24622871
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23348643
65KDM5A_27292631_Chip-Seq_BREAST_Human1.22639168
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22320973
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21674000
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.21065669
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19823044
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.17601358
71MYC_18940864_ChIP-ChIP_HL60_Human1.17046506
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16456032
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15184474
74ZNF263_19887448_ChIP-Seq_K562_Human1.12271772
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11998915
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.11825036
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11223778
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.09494399
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09298255
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09151052
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07932997
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07457080
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05178220
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03485517
85TFEB_21752829_ChIP-Seq_HELA_Human1.03245874
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03040007
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01808387
88* SPI1_23547873_ChIP-Seq_NB4_Human0.98774392
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98610828
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.98370096
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97921787
92BCL6_27268052_Chip-Seq_Bcells_Human0.97597857
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94767970
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94240733
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94191182
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93865651
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92030153
98MYC_22102868_ChIP-Seq_BL_Human0.91958697
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91738142
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91290359
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89774393
102CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89765353
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89513211
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88822018
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88533244
106P68_20966046_ChIP-Seq_HELA_Human0.86787563
107IRF1_19129219_ChIP-ChIP_H3396_Human0.86155351
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85152207
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85151684
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85140473
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84040816
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83847174
113YY1_22570637_ChIP-Seq_MALME-3M_Human0.82785046
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80936737
115VDR_21846776_ChIP-Seq_THP-1_Human0.79064719
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.77784223
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77212388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03592657
2MP0004957_abnormal_blastocyst_morpholog3.88627663
3MP0010094_abnormal_chromosome_stability3.45439342
4MP0003077_abnormal_cell_cycle3.42744332
5MP0003806_abnormal_nucleotide_metabolis3.42620212
6MP0003111_abnormal_nucleus_morphology3.39314868
7MP0008058_abnormal_DNA_repair3.21592434
8MP0006292_abnormal_olfactory_placode2.99374872
9MP0004145_abnormal_muscle_electrophysio2.95923869
10MP0008057_abnormal_DNA_replication2.75695155
11MP0008007_abnormal_cellular_replicative2.69304701
12MP0009379_abnormal_foot_pigmentation2.62922767
13MP0000749_muscle_degeneration2.55752045
14MP0002132_abnormal_respiratory_system2.54694060
15MP0008932_abnormal_embryonic_tissue2.41763438
16MP0003786_premature_aging2.40391171
17MP0003718_maternal_effect2.29869564
18MP0005451_abnormal_body_composition2.27279980
19MP0006036_abnormal_mitochondrial_physio2.19440312
20MP0003186_abnormal_redox_activity2.15574269
21MP0000751_myopathy2.12232862
22MP0002837_dystrophic_cardiac_calcinosis2.02080966
23MP0005360_urolithiasis1.99443812
24MP0008260_abnormal_autophagy1.94768627
25MP0002822_catalepsy1.92451035
26MP0001661_extended_life_span1.91438737
27MP0009333_abnormal_splenocyte_physiolog1.86229048
28MP0002396_abnormal_hematopoietic_system1.84916324
29MP0005330_cardiomyopathy1.70927831
30MP0006035_abnormal_mitochondrial_morpho1.64447442
31MP0005671_abnormal_response_to1.63696970
32MP0003763_abnormal_thymus_physiology1.63336200
33MP0002139_abnormal_hepatobiliary_system1.60475849
34MP0004233_abnormal_muscle_weight1.56918279
35MP0004147_increased_porphyrin_level1.55658844
36MP0008877_abnormal_DNA_methylation1.55483898
37MP0005075_abnormal_melanosome_morpholog1.54256938
38MP0005332_abnormal_amino_acid1.54247112
39MP0001835_abnormal_antigen_presentation1.54231068
40MP0002102_abnormal_ear_morphology1.50172543
41MP0002938_white_spotting1.49493794
42MP0003011_delayed_dark_adaptation1.45559975
43MP0004036_abnormal_muscle_relaxation1.45034486
44MP0000490_abnormal_crypts_of1.44701280
45MP0001730_embryonic_growth_arrest1.43384384
46MP0002234_abnormal_pharynx_morphology1.42774057
47MP0001529_abnormal_vocalization1.40779722
48MP0002106_abnormal_muscle_physiology1.40432000
49MP0000350_abnormal_cell_proliferation1.39858377
50MP0004133_heterotaxia1.39416195
51MP0001764_abnormal_homeostasis1.38288038
52MP0001853_heart_inflammation1.37516629
53MP0002019_abnormal_tumor_incidence1.36406281
54MP0000313_abnormal_cell_death1.35072306
55MP0009697_abnormal_copulation1.33252813
56MP0001727_abnormal_embryo_implantation1.32968879
57MP0000689_abnormal_spleen_morphology1.31623242
58MP0002638_abnormal_pupillary_reflex1.29251415
59MP0008875_abnormal_xenobiotic_pharmacok1.29150617
60MP0000358_abnormal_cell_content/1.27289169
61MP0002398_abnormal_bone_marrow1.26186914
62MP0009785_altered_susceptibility_to1.24910123
63MP0000759_abnormal_skeletal_muscle1.23167739
64MP0000747_muscle_weakness1.22569304
65MP0005319_abnormal_enzyme/_coenzyme1.21839666
66MP0002722_abnormal_immune_system1.20952780
67MP0005085_abnormal_gallbladder_physiolo1.14807339
68MP0000566_synostosis1.14492468
69MP0001545_abnormal_hematopoietic_system1.13636331
70MP0005397_hematopoietic_system_phenotyp1.13636331
71MP0005365_abnormal_bile_salt1.11865296
72MP0001986_abnormal_taste_sensitivity1.11031405
73MP0010030_abnormal_orbit_morphology1.09768368
74MP0002095_abnormal_skin_pigmentation1.09708999
75MP0002429_abnormal_blood_cell1.09285919
76MP0003136_yellow_coat_color1.07871726
77MP0003315_abnormal_perineum_morphology1.07139082
78MP0002080_prenatal_lethality1.07065113
79MP0001293_anophthalmia1.05204301
80MP0002249_abnormal_larynx_morphology1.04775007
81MP0005670_abnormal_white_adipose1.04706333
82MP0005174_abnormal_tail_pigmentation1.01566610
83MP0003123_paternal_imprinting1.01492561
84MP0000015_abnormal_ear_pigmentation1.01241014
85MP0000858_altered_metastatic_potential1.00452401
86MP0000703_abnormal_thymus_morphology1.00165401
87MP0005266_abnormal_metabolism1.00036860
88MP0005369_muscle_phenotype0.99645023
89MP0003646_muscle_fatigue0.99588776
90MP0002163_abnormal_gland_morphology0.99531582
91MP0005584_abnormal_enzyme/coenzyme_acti0.99528334
92MP0000716_abnormal_immune_system0.98036589
93MP0001697_abnormal_embryo_size0.97514625
94MP0002210_abnormal_sex_determination0.97392011
95MP0003656_abnormal_erythrocyte_physiolo0.96442230
96MP0004808_abnormal_hematopoietic_stem0.95341540
97MP0003567_abnormal_fetal_cardiomyocyte0.95136194
98MP0000685_abnormal_immune_system0.94945305
99MP0009840_abnormal_foam_cell0.92541477
100MP0005025_abnormal_response_to0.92435122
101MP0004087_abnormal_muscle_fiber0.90436695
102MP0002269_muscular_atrophy0.90358724
103MP0002277_abnormal_respiratory_mucosa0.89618374
104MP0002420_abnormal_adaptive_immunity0.87763451
105MP0000049_abnormal_middle_ear0.87628392
106MP0001800_abnormal_humoral_immune0.86705521
107MP0001145_abnormal_male_reproductive0.86675613
108MP0001819_abnormal_immune_cell0.86353109
109MP0001905_abnormal_dopamine_level0.85638119
110MP0003724_increased_susceptibility_to0.81938487
111MP0002736_abnormal_nociception_after0.81145523
112MP0005394_taste/olfaction_phenotype0.80918052
113MP0005499_abnormal_olfactory_system0.80918052
114MP0004142_abnormal_muscle_tone0.80359774
115MP0003191_abnormal_cellular_cholesterol0.78959709
116MP0003137_abnormal_impulse_conducting0.78845778
117MP0002405_respiratory_system_inflammati0.78665904
118MP0002160_abnormal_reproductive_system0.78625178
119MP0001188_hyperpigmentation0.78393038
120MP0002723_abnormal_immune_serum0.78085081
121MP0002148_abnormal_hypersensitivity_rea0.77936903
122MP0005058_abnormal_lysosome_morphology0.77188740
123MP0002452_abnormal_antigen_presenting0.76335346
124MP0005380_embryogenesis_phenotype0.73514641
125MP0001672_abnormal_embryogenesis/_devel0.73514641
126MP0001929_abnormal_gametogenesis0.72951390
127MP0005389_reproductive_system_phenotype0.72784759
128MP0000372_irregular_coat_pigmentation0.72207511
129MP0000750_abnormal_muscle_regeneration0.72161826
130MP0005367_renal/urinary_system_phenotyp0.70625569
131MP0000516_abnormal_urinary_system0.70625569
132MP0000653_abnormal_sex_gland0.70508508
133MP0008789_abnormal_olfactory_epithelium0.70214984
134MP0002085_abnormal_embryonic_tissue0.69609936
135MP0001119_abnormal_female_reproductive0.69085835
136MP0002138_abnormal_hepatobiliary_system0.68514063
137MP0005000_abnormal_immune_tolerance0.68273960
138MP0008469_abnormal_protein_level0.68093772
139MP0004185_abnormal_adipocyte_glucose0.66883667
140MP0000678_abnormal_parathyroid_gland0.66215393
141MP0005636_abnormal_mineral_homeostasis0.66101121
142MP0009643_abnormal_urine_homeostasis0.62129641
143MP0005376_homeostasis/metabolism_phenot0.61473169
144MP0003984_embryonic_growth_retardation0.60323086
145MP0002972_abnormal_cardiac_muscle0.59503486

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.74518554
2Abnormal number of erythroid precursors (HP:0012131)5.35160528
3Reticulocytopenia (HP:0001896)4.48428401
4Acute necrotizing encephalopathy (HP:0006965)4.35158762
5Hepatocellular necrosis (HP:0001404)4.27688635
6Mitochondrial inheritance (HP:0001427)4.26585652
7Abnormal mitochondria in muscle tissue (HP:0008316)4.08499278
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.99224194
9Nemaline bodies (HP:0003798)3.97742252
10Muscle fiber inclusion bodies (HP:0100299)3.96607451
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.95978310
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.95978310
13Hepatic necrosis (HP:0002605)3.87112909
14Increased CSF lactate (HP:0002490)3.84739900
15Increased hepatocellular lipid droplets (HP:0006565)3.84475677
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.81869109
17Birth length less than 3rd percentile (HP:0003561)3.77355787
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65093401
19Acute encephalopathy (HP:0006846)3.64178402
20Macrocytic anemia (HP:0001972)3.60590077
21Aplastic anemia (HP:0001915)3.51026966
22Lipid accumulation in hepatocytes (HP:0006561)3.45203893
23Progressive macrocephaly (HP:0004481)3.41081214
24Increased serum lactate (HP:0002151)3.38919595
25Renal Fanconi syndrome (HP:0001994)3.32868262
26Type I transferrin isoform profile (HP:0003642)3.31655995
27Rhabdomyolysis (HP:0003201)3.30704105
28Pallor (HP:0000980)3.27568428
29Oral leukoplakia (HP:0002745)3.23866241
30Exercise intolerance (HP:0003546)3.09997385
313-Methylglutaconic aciduria (HP:0003535)3.06645366
32Cerebral hypomyelination (HP:0006808)3.06360173
33Increased intramyocellular lipid droplets (HP:0012240)3.06044507
34Lactic acidosis (HP:0003128)3.00301759
35Microretrognathia (HP:0000308)2.96188553
36Exercise-induced muscle cramps (HP:0003710)2.94573237
37Ragged-red muscle fibers (HP:0003200)2.94383763
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93135071
39Exertional dyspnea (HP:0002875)2.84071455
40Myopathic facies (HP:0002058)2.82205079
41Microvesicular hepatic steatosis (HP:0001414)2.82035232
42Increased serum pyruvate (HP:0003542)2.79798513
43Abnormality of glycolysis (HP:0004366)2.79798513
44Cerebral edema (HP:0002181)2.78464091
45Breast hypoplasia (HP:0003187)2.73732150
46Exercise-induced myalgia (HP:0003738)2.61835522
47Increased muscle lipid content (HP:0009058)2.58906016
48Respiratory difficulties (HP:0002880)2.58866799
49Myoglobinuria (HP:0002913)2.55136577
50Pancytopenia (HP:0001876)2.50234450
51Progressive muscle weakness (HP:0003323)2.49645561
52Respiratory failure (HP:0002878)2.46826203
53Absent thumb (HP:0009777)2.45408050
54Abnormal protein glycosylation (HP:0012346)2.41500808
55Abnormal glycosylation (HP:0012345)2.41500808
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41500808
57Abnormal protein N-linked glycosylation (HP:0012347)2.41500808
58Generalized aminoaciduria (HP:0002909)2.40723707
59Type 2 muscle fiber atrophy (HP:0003554)2.38514586
60Rimmed vacuoles (HP:0003805)2.36713661
61Muscle fiber atrophy (HP:0100295)2.34976138
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33799097
63Dicarboxylic aciduria (HP:0003215)2.33799097
64Abnormality of the anterior horn cell (HP:0006802)2.33195546
65Degeneration of anterior horn cells (HP:0002398)2.33195546
66Poor head control (HP:0002421)2.33154015
67Reduced antithrombin III activity (HP:0001976)2.31813367
68CNS demyelination (HP:0007305)2.28719484
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28128467
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.27420817
71Rough bone trabeculation (HP:0100670)2.26880940
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25421707
73Abnormality of pyrimidine metabolism (HP:0004353)2.23416532
74Abnormality of DNA repair (HP:0003254)2.22180102
75Patellar aplasia (HP:0006443)2.14549957
76Amniotic constriction ring (HP:0009775)2.14547438
77Abnormality of placental membranes (HP:0011409)2.14547438
78Muscle hypertrophy of the lower extremities (HP:0008968)2.10308204
79Trismus (HP:0000211)2.09948567
80IgM deficiency (HP:0002850)2.08676684
81Premature graying of hair (HP:0002216)2.08282390
82Thyroid-stimulating hormone excess (HP:0002925)2.07825949
83Muscle stiffness (HP:0003552)2.07684112
84Elevated erythrocyte sedimentation rate (HP:0003565)2.06652102
85Aplasia/hypoplasia of the uterus (HP:0008684)2.04119974
86Abnormal number of incisors (HP:0011064)2.02924443
87Aplasia/Hypoplasia of the patella (HP:0006498)2.02635469
88Abnormality of fatty-acid metabolism (HP:0004359)2.02574874
89Poikiloderma (HP:0001029)2.01712678
90Emotional lability (HP:0000712)2.01333532
91Selective tooth agenesis (HP:0001592)2.00319694
92Hyperphosphaturia (HP:0003109)1.99499081
93Distal arthrogryposis (HP:0005684)1.99164470
94Abnormal pupillary function (HP:0007686)1.96929521
95Sparse eyelashes (HP:0000653)1.95381470
96Colon cancer (HP:0003003)1.94875137
97Chromsome breakage (HP:0040012)1.94264456
98Hyperglycinemia (HP:0002154)1.91849767
99Lethargy (HP:0001254)1.89824393
100Testicular atrophy (HP:0000029)1.89229900
101Cleft eyelid (HP:0000625)1.88956503
102Type 1 muscle fiber predominance (HP:0003803)1.88908642
103Abnormality of renal resorption (HP:0011038)1.88109147
104Hypoplastic heart (HP:0001961)1.86910387
105Abnormality of the preputium (HP:0100587)1.86426533
106Cellular immunodeficiency (HP:0005374)1.85369905
107Leukodystrophy (HP:0002415)1.84994882
108Triphalangeal thumb (HP:0001199)1.84950291
109Methylmalonic aciduria (HP:0012120)1.84894906
110Carpal bone hypoplasia (HP:0001498)1.84722479
111Optic disc pallor (HP:0000543)1.84578475
112Secondary amenorrhea (HP:0000869)1.82848328
113Abnormality of serine family amino acid metabolism (HP:0010894)1.81817343
114Abnormality of glycine metabolism (HP:0010895)1.81817343
115Agnosia (HP:0010524)1.81337553
116Bone marrow hypocellularity (HP:0005528)1.81170617
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80657977
118CNS hypomyelination (HP:0003429)1.79255291
119Metabolic acidosis (HP:0001942)1.79161634
120Meckel diverticulum (HP:0002245)1.78829480
121Thrombocytosis (HP:0001894)1.78195866
122Abnormality of reticulocytes (HP:0004312)1.77939067
123X-linked dominant inheritance (HP:0001423)1.77601248
124Gliosis (HP:0002171)1.76937255
125Delayed CNS myelination (HP:0002188)1.76920656
126Hyperglycinuria (HP:0003108)1.75190727
127Hypoplastic left heart (HP:0004383)1.74001340
128Prolonged neonatal jaundice (HP:0006579)1.73775542
129Gout (HP:0001997)1.73119134
130Nausea (HP:0002018)1.71690295
131Vomiting (HP:0002013)1.71587243
132Dry hair (HP:0011359)1.71585152
133Calf muscle hypertrophy (HP:0008981)1.71421056
134Abnormality of urine glucose concentration (HP:0011016)1.71006814
135Glycosuria (HP:0003076)1.71006814
136Abnormality of the ileum (HP:0001549)1.70308217
137Premature ovarian failure (HP:0008209)1.69466483
13811 pairs of ribs (HP:0000878)1.69144370
139Hypoplasia of the radius (HP:0002984)1.68163938
140Postnatal microcephaly (HP:0005484)1.67713986
141Hypoplasia of the uterus (HP:0000013)1.67183951
142Hyperammonemia (HP:0001987)1.64293576
143Paralysis (HP:0003470)1.62265983
144EMG: myopathic abnormalities (HP:0003458)1.61508817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.67655612
2BUB15.32363649
3EIF2AK14.07331720
4NME23.74832732
5WEE13.65095466
6STK163.36447963
7ACVR1B2.39154973
8EIF2AK32.36907121
9VRK12.21662616
10TSSK62.18313110
11PIM22.11637137
12TLK12.11635359
13SRPK12.02438518
14BCKDK1.99311317
15KDR1.98779382
16BRAF1.98589996
17TAF11.98416846
18CDC71.98366109
19TESK21.97140104
20SMG11.90931919
21DYRK31.79370443
22NME11.78926105
23PDK21.60630811
24PLK41.54488222
25PHKG21.48074570
26PHKG11.48074570
27CSNK1G31.38083510
28BRSK21.35323792
29MUSK1.33781417
30NEK21.32211806
31MAP4K11.30676806
32CDK71.30440434
33PLK11.30134464
34MAP3K111.28318945
35AURKA1.23089469
36ARAF1.21358105
37RPS6KB21.17083359
38BRSK11.17007999
39NUAK11.15899102
40CDK81.14920620
41TTK1.14593294
42DAPK11.12692749
43YES11.09844257
44IRAK41.09720539
45DYRK21.09107309
46ABL21.08746895
47AURKB1.08486158
48CSNK1G11.03787910
49PBK1.00710115
50CSNK1A1L0.97411495
51RPS6KA40.96391478
52ZAK0.94907129
53PASK0.94322243
54PAK40.93980736
55DAPK30.93275940
56ATR0.93122397
57NEK10.92903665
58KIT0.92240881
59LRRK20.90986781
60CSNK1G20.90723305
61TESK10.88962329
62MAP4K20.87364011
63PLK30.85700956
64BLK0.84305466
65MAP2K30.81625595
66TTN0.81305301
67PINK10.80165882
68MKNK10.80035493
69ADRBK20.79468810
70CSNK2A10.79059478
71CHEK20.77500111
72MST40.76793621
73CCNB10.75144863
74IRAK30.73774973
75NLK0.73240691
76ILK0.73225698
77TGFBR10.72466876
78MAP3K80.72260738
79CDK190.71788041
80PAK10.71323331
81CSNK2A20.71190475
82MAPKAPK30.70676386
83PRKD30.70600461
84EPHA20.68482958
85CDK40.67479881
86MKNK20.66782526
87ZAP700.66709005
88LIMK10.66693757
89GRK60.65895558
90EIF2AK20.64474066
91PIK3CG0.64439469
92MYLK0.64191509
93FLT30.64108911
94STK40.63924269
95TNIK0.62724663
96TXK0.61841000
97STK240.59574243
98PIM10.59183963
99BTK0.56259178
100RPS6KA50.56161581
101TBK10.56079518
102OBSCN0.55172693
103TYK20.54355880
104CASK0.53233221
105CHEK10.51110649
106DYRK1B0.48756726
107LYN0.47268738
108PRKCI0.46992796
109CAMK2G0.44913659
110CLK10.44747567
111MAP3K120.41992140
112BMPR1B0.41513485
113CSF1R0.39554571
114RAF10.39357967
115AKT20.38462550
116TNK20.38165028
117TAOK20.36346122
118MAP2K70.35444991
119MAPK110.34847578
120TEC0.34091348
121IKBKB0.32975841
122IRAK20.32007774
123SYK0.31609331
124CDK20.29494649
125MATK0.29357626
126LCK0.28948438
127CDK11A0.28019862
128EPHB10.24511659
129CDK140.23123284

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.81162226
2Ribosome_Homo sapiens_hsa030104.77790300
3DNA replication_Homo sapiens_hsa030304.20057218
4RNA polymerase_Homo sapiens_hsa030203.72705276
5Mismatch repair_Homo sapiens_hsa034303.66210834
6Spliceosome_Homo sapiens_hsa030402.90680913
7Nucleotide excision repair_Homo sapiens_hsa034202.76310744
8Base excision repair_Homo sapiens_hsa034102.76142903
9Pyrimidine metabolism_Homo sapiens_hsa002402.74587948
10* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74424284
11Homologous recombination_Homo sapiens_hsa034402.58551172
12Oxidative phosphorylation_Homo sapiens_hsa001902.48421654
13Parkinsons disease_Homo sapiens_hsa050122.21667312
14* RNA transport_Homo sapiens_hsa030132.13078301
15Protein export_Homo sapiens_hsa030602.08982978
16One carbon pool by folate_Homo sapiens_hsa006701.85158459
17Huntingtons disease_Homo sapiens_hsa050161.72271778
18Basal transcription factors_Homo sapiens_hsa030221.68423854
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67255086
20RNA degradation_Homo sapiens_hsa030181.62137411
21Non-homologous end-joining_Homo sapiens_hsa034501.59385297
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57695973
23Folate biosynthesis_Homo sapiens_hsa007901.51665084
24Fanconi anemia pathway_Homo sapiens_hsa034601.51129545
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50850824
26Cell cycle_Homo sapiens_hsa041101.48145738
27Purine metabolism_Homo sapiens_hsa002301.46063413
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30709645
29Alzheimers disease_Homo sapiens_hsa050101.29260002
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28846126
31Sulfur metabolism_Homo sapiens_hsa009201.22476452
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19787320
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18424408
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18223223
35Propanoate metabolism_Homo sapiens_hsa006401.14531707
36Sulfur relay system_Homo sapiens_hsa041221.12574323
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05476648
38Pentose phosphate pathway_Homo sapiens_hsa000301.03579606
39Biosynthesis of amino acids_Homo sapiens_hsa012301.02789504
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01852409
41Epstein-Barr virus infection_Homo sapiens_hsa051690.91618104
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.88201206
43Fatty acid degradation_Homo sapiens_hsa000710.87624022
44p53 signaling pathway_Homo sapiens_hsa041150.84696148
45Arginine biosynthesis_Homo sapiens_hsa002200.84080392
46Carbon metabolism_Homo sapiens_hsa012000.83870678
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82682136
48Glutathione metabolism_Homo sapiens_hsa004800.82313455
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.80612429
50mRNA surveillance pathway_Homo sapiens_hsa030150.77663115
51Fructose and mannose metabolism_Homo sapiens_hsa000510.74839564
52Fatty acid metabolism_Homo sapiens_hsa012120.74660470
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73719719
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70719752
55Systemic lupus erythematosus_Homo sapiens_hsa053220.70246438
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69119974
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68106964
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68085704
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67063079
60Primary immunodeficiency_Homo sapiens_hsa053400.66334524
61Butanoate metabolism_Homo sapiens_hsa006500.65931731
62Metabolic pathways_Homo sapiens_hsa011000.65895458
63Galactose metabolism_Homo sapiens_hsa000520.63737169
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.61046507
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58877831
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58717618
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54244508
68Antigen processing and presentation_Homo sapiens_hsa046120.53800827
69Pyruvate metabolism_Homo sapiens_hsa006200.51797911
70Selenocompound metabolism_Homo sapiens_hsa004500.51628017
71Chemical carcinogenesis_Homo sapiens_hsa052040.50175022
72Herpes simplex infection_Homo sapiens_hsa051680.49767011
73Vitamin B6 metabolism_Homo sapiens_hsa007500.49673976
74Legionellosis_Homo sapiens_hsa051340.48188377
75N-Glycan biosynthesis_Homo sapiens_hsa005100.46912854
76Tryptophan metabolism_Homo sapiens_hsa003800.46888945
77Steroid biosynthesis_Homo sapiens_hsa001000.46876129
78Collecting duct acid secretion_Homo sapiens_hsa049660.45293164
79Cardiac muscle contraction_Homo sapiens_hsa042600.42354736
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42255335
81Arachidonic acid metabolism_Homo sapiens_hsa005900.41395071
82Arginine and proline metabolism_Homo sapiens_hsa003300.41272161
83Thyroid cancer_Homo sapiens_hsa052160.39189216
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38770253
85Allograft rejection_Homo sapiens_hsa053300.36707981
86Peroxisome_Homo sapiens_hsa041460.36281590
87Other glycan degradation_Homo sapiens_hsa005110.34002918
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.31908733
89Measles_Homo sapiens_hsa051620.28819579
90Starch and sucrose metabolism_Homo sapiens_hsa005000.28232323
91Caffeine metabolism_Homo sapiens_hsa002320.27782448
92Shigellosis_Homo sapiens_hsa051310.26561804
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26330211
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26078005
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24439312
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24331090
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21236151
98Viral carcinogenesis_Homo sapiens_hsa052030.21157997
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19992838
100Hematopoietic cell lineage_Homo sapiens_hsa046400.19794390
101Linoleic acid metabolism_Homo sapiens_hsa005910.18864762
102Retinol metabolism_Homo sapiens_hsa008300.18166531
103Fat digestion and absorption_Homo sapiens_hsa049750.17453570
104Type I diabetes mellitus_Homo sapiens_hsa049400.16365159
105HTLV-I infection_Homo sapiens_hsa051660.15884811
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15766129
107Asthma_Homo sapiens_hsa053100.15228316
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14871076
109Fatty acid elongation_Homo sapiens_hsa000620.14073241
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13501423
111Apoptosis_Homo sapiens_hsa042100.13231144
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.12982861
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12719469
114Vibrio cholerae infection_Homo sapiens_hsa051100.12215080
115Regulation of autophagy_Homo sapiens_hsa041400.12055386
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.11532866
117Phenylalanine metabolism_Homo sapiens_hsa003600.11445963
118Tyrosine metabolism_Homo sapiens_hsa003500.10963839
119Oocyte meiosis_Homo sapiens_hsa041140.10779840
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09900426
121beta-Alanine metabolism_Homo sapiens_hsa004100.09179036
122Graft-versus-host disease_Homo sapiens_hsa053320.09014072
123Alcoholism_Homo sapiens_hsa050340.08509753
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08393706

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