RPP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14993907
2kinetochore assembly (GO:0051382)4.97451456
3chaperone-mediated protein transport (GO:0072321)4.92490992
4kinetochore organization (GO:0051383)4.80516555
5proteasome assembly (GO:0043248)4.79664748
6DNA deamination (GO:0045006)4.73961823
7mitotic metaphase plate congression (GO:0007080)4.70750395
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.52933720
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50340380
10ATP synthesis coupled proton transport (GO:0015986)4.50340380
11telomere maintenance via semi-conservative replication (GO:0032201)4.48753943
12DNA replication initiation (GO:0006270)4.40805102
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.35636835
14negative regulation of ligase activity (GO:0051352)4.35636835
15purine nucleobase biosynthetic process (GO:0009113)4.23792922
16CENP-A containing nucleosome assembly (GO:0034080)4.23680966
17ribosome biogenesis (GO:0042254)4.17880093
18chromatin remodeling at centromere (GO:0031055)4.17687657
19DNA strand elongation involved in DNA replication (GO:0006271)4.16634342
20DNA replication checkpoint (GO:0000076)4.09533171
21nucleobase biosynthetic process (GO:0046112)4.09219802
22DNA strand elongation (GO:0022616)4.06022771
23telomere maintenance via recombination (GO:0000722)4.03802136
24ribosomal small subunit assembly (GO:0000028)4.00533091
25ribosomal large subunit biogenesis (GO:0042273)3.95712298
26maturation of SSU-rRNA (GO:0030490)3.93524000
27ribonucleoprotein complex biogenesis (GO:0022613)3.92335879
28cullin deneddylation (GO:0010388)3.92108074
29metaphase plate congression (GO:0051310)3.91672578
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.90361220
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.81186597
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.81186597
33positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.80831718
34pseudouridine synthesis (GO:0001522)3.79830369
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.79820423
36mitochondrial respiratory chain complex assembly (GO:0033108)3.78282067
37regulation of double-strand break repair via homologous recombination (GO:0010569)3.77780960
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77572752
39rRNA modification (GO:0000154)3.76415940
40protein complex biogenesis (GO:0070271)3.76175435
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.74593920
42telomere maintenance via telomere lengthening (GO:0010833)3.74145064
43respiratory electron transport chain (GO:0022904)3.72751281
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.71764730
45termination of RNA polymerase III transcription (GO:0006386)3.71764730
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70712447
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.70712447
48NADH dehydrogenase complex assembly (GO:0010257)3.70712447
49mitotic recombination (GO:0006312)3.70689369
50protein deneddylation (GO:0000338)3.70602260
51DNA catabolic process, exonucleolytic (GO:0000738)3.69985744
52positive regulation of ligase activity (GO:0051351)3.66030346
537-methylguanosine mRNA capping (GO:0006370)3.64748435
54electron transport chain (GO:0022900)3.64267641
55rRNA processing (GO:0006364)3.63505681
56ribosome assembly (GO:0042255)3.63342606
57protein targeting to mitochondrion (GO:0006626)3.61773119
58DNA replication-independent nucleosome assembly (GO:0006336)3.60513588
59DNA replication-independent nucleosome organization (GO:0034724)3.60513588
60RNA capping (GO:0036260)3.59894161
617-methylguanosine RNA capping (GO:0009452)3.59894161
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57414309
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57414309
64IMP biosynthetic process (GO:0006188)3.55779661
65rRNA metabolic process (GO:0016072)3.53205187
66spliceosomal snRNP assembly (GO:0000387)3.50775596
67tRNA methylation (GO:0030488)3.49257551
68termination of RNA polymerase I transcription (GO:0006363)3.48309482
69respiratory chain complex IV assembly (GO:0008535)3.48043776
70regulation of ubiquitin-protein transferase activity (GO:0051438)3.43829961
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.42628467
72protein K6-linked ubiquitination (GO:0085020)3.40723663
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.40529626
74protein localization to mitochondrion (GO:0070585)3.39419708
75translation (GO:0006412)3.39408787
76histone exchange (GO:0043486)3.38761532
77meiotic chromosome segregation (GO:0045132)3.38695099
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38597309
79ribosomal small subunit biogenesis (GO:0042274)3.37814144
80transcription from RNA polymerase I promoter (GO:0006360)3.35995586
81DNA double-strand break processing (GO:0000729)3.35828176
82establishment of chromosome localization (GO:0051303)3.34642412
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.34272332
84regulation of ligase activity (GO:0051340)3.32970933
85intra-S DNA damage checkpoint (GO:0031573)3.32691461
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.31277872
87establishment of protein localization to mitochondrion (GO:0072655)3.30940615
88DNA damage response, detection of DNA damage (GO:0042769)3.29234045
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29228894
90transcription-coupled nucleotide-excision repair (GO:0006283)3.29029424
91maturation of 5.8S rRNA (GO:0000460)3.25245632
92protein neddylation (GO:0045116)3.24266598
93cytochrome complex assembly (GO:0017004)3.18879420
94establishment of viral latency (GO:0019043)3.17499413
95deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17269903
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16918784
97cellular component biogenesis (GO:0044085)3.15493117
98attachment of spindle microtubules to kinetochore (GO:0008608)3.14729622
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14702045
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13839518
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12055508
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12048452
103rRNA methylation (GO:0031167)3.09873979
104histone mRNA metabolic process (GO:0008334)3.09232046
105establishment of integrated proviral latency (GO:0075713)3.08741861
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08430435
107protein localization to kinetochore (GO:0034501)3.07234963
108negative regulation of protein ubiquitination (GO:0031397)3.06615689
109DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.05601816
110telomere organization (GO:0032200)3.04231472
111telomere maintenance (GO:0000723)3.03593081
112deoxyribonucleotide biosynthetic process (GO:0009263)3.02419771
113oxidative phosphorylation (GO:0006119)3.02347475
114regulation of cellular amine metabolic process (GO:0033238)3.02111212
115* ncRNA processing (GO:0034470)3.01457375
116tRNA modification (GO:0006400)3.01165942
117DNA ligation (GO:0006266)3.00715982
118replication fork processing (GO:0031297)3.00510441
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99258054
120formation of translation preinitiation complex (GO:0001731)2.98803793
121viral mRNA export from host cell nucleus (GO:0046784)2.97694130
122regulation of mitochondrial translation (GO:0070129)2.95816504
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95624144
124transcription initiation from RNA polymerase I promoter (GO:0006361)2.95352742
125mitotic nuclear envelope disassembly (GO:0007077)2.93285076
126mismatch repair (GO:0006298)2.92368566
127mitochondrial RNA metabolic process (GO:0000959)2.90461363
128* ncRNA metabolic process (GO:0034660)2.90098458
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89973766
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89973766
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89973766
132viral transcription (GO:0019083)2.89561942
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.89132864
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88895310
135nuclear pore organization (GO:0006999)2.88850616
136DNA-templated transcription, termination (GO:0006353)2.88716559
137cell cycle G1/S phase transition (GO:0044843)2.88715825
138G1/S transition of mitotic cell cycle (GO:0000082)2.88715825
139translational termination (GO:0006415)2.87405238
140regulation of cellular amino acid metabolic process (GO:0006521)2.86894006
141spliceosomal complex assembly (GO:0000245)2.86289215
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85391443
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85391443
144protein localization to chromosome, centromeric region (GO:0071459)2.84993605
145isotype switching (GO:0045190)2.84813438
146somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84813438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41645324
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47841285
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16046669
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75153201
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43727424
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.20154950
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.17217698
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.08206025
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01936302
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95086048
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89947655
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89399248
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88507349
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86670740
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78184301
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71845900
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.70146880
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69243386
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66363990
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66227537
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56292065
22* VDR_23849224_ChIP-Seq_CD4+_Human2.52902798
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50397242
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44980055
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30528906
26FOXP3_21729870_ChIP-Seq_TREG_Human2.26934126
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14928663
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.12183356
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10750774
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08947982
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05128433
32AR_21909140_ChIP-Seq_LNCAP_Human2.00432580
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.98385425
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.98359065
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96714423
36XRN2_22483619_ChIP-Seq_HELA_Human1.96103368
37ELK1_19687146_ChIP-ChIP_HELA_Human1.96072381
38DCP1A_22483619_ChIP-Seq_HELA_Human1.93837550
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.93627425
40TTF2_22483619_ChIP-Seq_HELA_Human1.86773132
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.85631295
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79967832
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76102690
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71331565
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70566028
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69946392
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68233693
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68113848
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68034830
50GABP_19822575_ChIP-Seq_HepG2_Human1.66262229
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60465353
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57844863
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52156078
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51741679
55MYC_18940864_ChIP-ChIP_HL60_Human1.37774506
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36660325
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35955326
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33242864
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32116920
60IRF1_19129219_ChIP-ChIP_H3396_Human1.31608136
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27141260
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24829657
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22367545
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22217195
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.21288473
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18307526
67KDM5A_27292631_Chip-Seq_BREAST_Human1.17652259
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16429045
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11790096
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09110606
71CIITA_25753668_ChIP-Seq_RAJI_Human1.08148032
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05674573
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96015704
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.95477558
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94649329
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94443884
77* ZNF274_21170338_ChIP-Seq_K562_Hela0.91983696
78SALL1_21062744_ChIP-ChIP_HESCs_Human0.91370945
79VDR_22108803_ChIP-Seq_LS180_Human0.91221999
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90484661
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.88968022
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88586875
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88247693
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86465257
85FUS_26573619_Chip-Seq_HEK293_Human0.85170567
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84235835
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83620940
88ELF5_23300383_ChIP-Seq_T47D_Human0.82987848
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81900807
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80001972
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.78604034
92BP1_19119308_ChIP-ChIP_Hs578T_Human0.76041839
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74858826
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.74684076
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74414540
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74177078
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72440466
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71893902
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71671146
100SPI1_23547873_ChIP-Seq_NB4_Human0.71584969
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71532409
102TFEB_21752829_ChIP-Seq_HELA_Human0.70569779
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68361398
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68325615
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.65089173
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64508248
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.63912345
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63677803
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.63589746
110TP53_22573176_ChIP-Seq_HFKS_Human0.63579682
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.63467592
112* EWS_26573619_Chip-Seq_HEK293_Human0.61576501
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.61316816
114* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.60830611
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.59973084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.11492988
2MP0008057_abnormal_DNA_replication4.47872291
3MP0010094_abnormal_chromosome_stability4.06748290
4MP0008058_abnormal_DNA_repair4.05497298
5MP0003111_abnormal_nucleus_morphology3.90852926
6MP0004957_abnormal_blastocyst_morpholog3.32104340
7MP0003077_abnormal_cell_cycle3.28935473
8MP0006292_abnormal_olfactory_placode3.07317553
9MP0003136_yellow_coat_color2.95296688
10MP0008007_abnormal_cellular_replicative2.87287836
11MP0002396_abnormal_hematopoietic_system2.72294847
12MP0000566_synostosis2.68342450
13MP0001188_hyperpigmentation2.64959532
14MP0008877_abnormal_DNA_methylation2.58339263
15MP0003718_maternal_effect2.43396744
16MP0008932_abnormal_embryonic_tissue2.31418023
17MP0003786_premature_aging2.18886393
18MP0006035_abnormal_mitochondrial_morpho2.02946985
19MP0002102_abnormal_ear_morphology2.00830920
20MP0003123_paternal_imprinting1.81803403
21MP0006072_abnormal_retinal_apoptosis1.68041524
22MP0009379_abnormal_foot_pigmentation1.66675751
23MP0004381_abnormal_hair_follicle1.60129009
24MP0003941_abnormal_skin_development1.59526559
25MP0002277_abnormal_respiratory_mucosa1.58932217
26MP0003315_abnormal_perineum_morphology1.52127753
27MP0002210_abnormal_sex_determination1.51517049
28MP0009697_abnormal_copulation1.49537943
29MP0002132_abnormal_respiratory_system1.46582014
30MP0005075_abnormal_melanosome_morpholog1.46333120
31MP0001853_heart_inflammation1.41483812
32MP0000350_abnormal_cell_proliferation1.39106079
33MP0000490_abnormal_crypts_of1.38137452
34MP0003186_abnormal_redox_activity1.37758962
35MP0002638_abnormal_pupillary_reflex1.34531038
36MP0000358_abnormal_cell_content/1.31792263
37MP0001730_embryonic_growth_arrest1.30905591
38MP0002736_abnormal_nociception_after1.29573758
39MP0003890_abnormal_embryonic-extraembry1.29378456
40MP0002160_abnormal_reproductive_system1.28647452
41MP0001986_abnormal_taste_sensitivity1.28312218
42MP0002163_abnormal_gland_morphology1.27334449
43MP0003567_abnormal_fetal_cardiomyocyte1.24222579
44MP0003121_genomic_imprinting1.23636082
45MP0010030_abnormal_orbit_morphology1.22851635
46MP0008875_abnormal_xenobiotic_pharmacok1.20488617
47MP0005451_abnormal_body_composition1.20143286
48MP0002938_white_spotting1.17365121
49MP0001145_abnormal_male_reproductive1.15477514
50MP0003950_abnormal_plasma_membrane1.13881061
51MP0008789_abnormal_olfactory_epithelium1.13003120
52MP0003806_abnormal_nucleotide_metabolis1.11049311
53MP0005084_abnormal_gallbladder_morpholo1.09000845
54MP0000313_abnormal_cell_death1.08735712
55MP0008872_abnormal_physiological_respon1.08257710
56MP0005380_embryogenesis_phenotype1.06304638
57MP0001672_abnormal_embryogenesis/_devel1.06304638
58MP0005389_reproductive_system_phenotype1.05964011
59MP0002095_abnormal_skin_pigmentation1.05264720
60MP0001529_abnormal_vocalization1.04994769
61MP0000653_abnormal_sex_gland1.03848991
62MP0005409_darkened_coat_color1.03730079
63MP0001881_abnormal_mammary_gland1.03707587
64MP0003787_abnormal_imprinting1.03537239
65MP0001929_abnormal_gametogenesis1.03442257
66MP0008995_early_reproductive_senescence1.02427155
67MP0001293_anophthalmia1.00275833
68MP0000015_abnormal_ear_pigmentation0.98309408
69MP0001119_abnormal_female_reproductive0.96900919
70MP0004147_increased_porphyrin_level0.95926927
71MP0002249_abnormal_larynx_morphology0.92247484
72MP0002019_abnormal_tumor_incidence0.89701349
73MP0003938_abnormal_ear_development0.88923597
74MP0001697_abnormal_embryo_size0.87396113
75MP0001764_abnormal_homeostasis0.87219786
76MP0001919_abnormal_reproductive_system0.86320439
77MP0004808_abnormal_hematopoietic_stem0.85834193
78MP0005410_abnormal_fertilization0.84822034
79MP0000613_abnormal_salivary_gland0.84645261
80MP0003984_embryonic_growth_retardation0.82567217
81MP0000516_abnormal_urinary_system0.82433605
82MP0005367_renal/urinary_system_phenotyp0.82433605
83MP0005397_hematopoietic_system_phenotyp0.81573049
84MP0001545_abnormal_hematopoietic_system0.81573049
85MP0002085_abnormal_embryonic_tissue0.81355855
86MP0008873_increased_physiological_sensi0.80139322
87MP0003763_abnormal_thymus_physiology0.79661002
88MP0001286_abnormal_eye_development0.79279948
89MP0000372_irregular_coat_pigmentation0.78959165
90MP0002088_abnormal_embryonic_growth/wei0.77674478
91MP0006036_abnormal_mitochondrial_physio0.76649683
92MP0003011_delayed_dark_adaptation0.75562379
93MP0001485_abnormal_pinna_reflex0.75516528
94MP0005174_abnormal_tail_pigmentation0.74534329
95MP0003937_abnormal_limbs/digits/tail_de0.74479389
96MP0002080_prenatal_lethality0.73940913
97MP0001186_pigmentation_phenotype0.72523621
98MP0005253_abnormal_eye_physiology0.71547786
99MP0005499_abnormal_olfactory_system0.70463534
100MP0005394_taste/olfaction_phenotype0.70463534
101MP0005501_abnormal_skin_physiology0.70457017
102MP0003221_abnormal_cardiomyocyte_apopto0.68621188
103MP0001727_abnormal_embryo_implantation0.68488481
104MP0005379_endocrine/exocrine_gland_phen0.67826751
105MP0001968_abnormal_touch/_nociception0.67254099
106MP0002233_abnormal_nose_morphology0.67220010
107MP0005332_abnormal_amino_acid0.67148936
108MP0005395_other_phenotype0.66450853
109MP0001346_abnormal_lacrimal_gland0.66166655
110MP0004215_abnormal_myocardial_fiber0.65589322
111MP0009333_abnormal_splenocyte_physiolog0.64609504
112MP0005266_abnormal_metabolism0.64387157
113MP0001905_abnormal_dopamine_level0.64104124
114MP0005551_abnormal_eye_electrophysiolog0.63785826
115MP0003698_abnormal_male_reproductive0.63754844
116MP0008260_abnormal_autophagy0.63739645
117MP0005645_abnormal_hypothalamus_physiol0.63470154
118MP0004782_abnormal_surfactant_physiolog0.62551750
119MP0005646_abnormal_pituitary_gland0.61953148
120MP0003936_abnormal_reproductive_system0.61840579
121MP0005636_abnormal_mineral_homeostasis0.61572783
122MP0002111_abnormal_tail_morphology0.61189795
123MP0003195_calcinosis0.59134005
124MP0003252_abnormal_bile_duct0.59114911
125MP0002086_abnormal_extraembryonic_tissu0.58725758
126MP0005408_hypopigmentation0.57328074
127MP0000049_abnormal_middle_ear0.56860201
128MP0002084_abnormal_developmental_patter0.55606317
129MP0000703_abnormal_thymus_morphology0.55097831
130MP0000689_abnormal_spleen_morphology0.54746595
131MP0000647_abnormal_sebaceous_gland0.54421145
132MP0002090_abnormal_vision0.54203385
133MP0010307_abnormal_tumor_latency0.52594375

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.51949244
2Chromsome breakage (HP:0040012)5.31015381
3Birth length less than 3rd percentile (HP:0003561)5.09482993
4Acute encephalopathy (HP:0006846)4.94454407
5Progressive macrocephaly (HP:0004481)4.39218704
6Reticulocytopenia (HP:0001896)4.29980991
7Cerebral edema (HP:0002181)3.74334606
8Breast hypoplasia (HP:0003187)3.73710659
9Abnormality of the preputium (HP:0100587)3.58149647
10Duplicated collecting system (HP:0000081)3.51022952
11Abnormality of chromosome stability (HP:0003220)3.31404429
12Meckel diverticulum (HP:0002245)3.28915136
13Abnormal number of erythroid precursors (HP:0012131)3.27337846
14Lactic acidosis (HP:0003128)3.21083029
15Abnormality of cells of the erythroid lineage (HP:0012130)3.18690310
16Abnormality of the renal collecting system (HP:0004742)3.15787338
17Abnormality of the ileum (HP:0001549)3.15629147
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.01708717
19Increased serum pyruvate (HP:0003542)2.99414161
20Patellar aplasia (HP:0006443)2.98752069
21Rough bone trabeculation (HP:0100670)2.97015935
22Oral leukoplakia (HP:0002745)2.93218147
23Aplastic anemia (HP:0001915)2.89393698
24Reduced antithrombin III activity (HP:0001976)2.87833489
25Respiratory failure (HP:0002878)2.87666014
26Renal Fanconi syndrome (HP:0001994)2.87585802
27Increased intramyocellular lipid droplets (HP:0012240)2.86685398
28Abnormal protein glycosylation (HP:0012346)2.83423751
29Abnormal glycosylation (HP:0012345)2.83423751
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.83423751
31Abnormal protein N-linked glycosylation (HP:0012347)2.83423751
32Premature graying of hair (HP:0002216)2.80178744
33Colon cancer (HP:0003003)2.78792036
34Exercise intolerance (HP:0003546)2.77905506
35Aplasia/Hypoplasia of the patella (HP:0006498)2.75250611
36Abnormality of glycolysis (HP:0004366)2.73728571
373-Methylglutaconic aciduria (HP:0003535)2.67368780
38Macrocytic anemia (HP:0001972)2.65785451
39Leukodystrophy (HP:0002415)2.65608571
40Ectopic kidney (HP:0000086)2.63747706
41Impulsivity (HP:0100710)2.63186546
42Increased hepatocellular lipid droplets (HP:0006565)2.61954489
43Abnormality of methionine metabolism (HP:0010901)2.61008718
44Abnormal trabecular bone morphology (HP:0100671)2.59360288
45Bone marrow hypocellularity (HP:0005528)2.58465808
46Absent thumb (HP:0009777)2.56421070
47Small intestinal stenosis (HP:0012848)2.56194962
48Duodenal stenosis (HP:0100867)2.56194962
49Abnormality of the labia minora (HP:0012880)2.56136475
50Absent radius (HP:0003974)2.55068776
51Lethargy (HP:0001254)2.52838690
52Pancytopenia (HP:0001876)2.51061743
53Pallor (HP:0000980)2.47572231
54Abnormality of alanine metabolism (HP:0010916)2.46745515
55Hyperalaninemia (HP:0003348)2.46745515
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46745515
57Triphalangeal thumb (HP:0001199)2.46459532
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43701497
59Horseshoe kidney (HP:0000085)2.42347656
60Abnormal spermatogenesis (HP:0008669)2.41088511
61Methylmalonic acidemia (HP:0002912)2.40160786
62Optic disc pallor (HP:0000543)2.38369343
63Methylmalonic aciduria (HP:0012120)2.37133497
64Aplasia involving forearm bones (HP:0009822)2.35887286
65Absent forearm bone (HP:0003953)2.35887286
66Myelodysplasia (HP:0002863)2.33404427
67Increased muscle lipid content (HP:0009058)2.33267047
68Carpal bone hypoplasia (HP:0001498)2.33111926
69Multiple enchondromatosis (HP:0005701)2.31475041
70Abnormality of pyrimidine metabolism (HP:0004353)2.29798188
71Abnormality of serum amino acid levels (HP:0003112)2.27762415
72CNS demyelination (HP:0007305)2.26949406
73Abnormality of DNA repair (HP:0003254)2.25736994
74Clubbing of toes (HP:0100760)2.24564482
75Sparse eyelashes (HP:0000653)2.23910401
76Pancreatic cysts (HP:0001737)2.19785273
77Nephroblastoma (Wilms tumor) (HP:0002667)2.18498800
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.17939179
79Microretrognathia (HP:0000308)2.17929844
80Acute necrotizing encephalopathy (HP:0006965)2.14208745
81Abnormal lung lobation (HP:0002101)2.14154816
82Abnormality of the duodenum (HP:0002246)2.14090382
83Lipid accumulation in hepatocytes (HP:0006561)2.13356732
84Pancreatic fibrosis (HP:0100732)2.12148235
85Type I transferrin isoform profile (HP:0003642)2.11274809
86Prostate neoplasm (HP:0100787)2.11169042
87Increased serum lactate (HP:0002151)2.10180039
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09637229
89Respiratory difficulties (HP:0002880)2.08563175
90Generalized aminoaciduria (HP:0002909)2.07453852
91Abnormality of midbrain morphology (HP:0002418)2.07358941
92Molar tooth sign on MRI (HP:0002419)2.07358941
93Duplication of thumb phalanx (HP:0009942)2.06817738
94Abnormality of placental membranes (HP:0011409)2.06310512
95Amniotic constriction ring (HP:0009775)2.06310512
96Increased CSF lactate (HP:0002490)2.05959871
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05379332
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05047139
99Cerebral hypomyelination (HP:0006808)2.04368620
100Muscle fiber atrophy (HP:0100295)2.04199150
101Ureteral duplication (HP:0000073)2.03817452
102Exertional dyspnea (HP:0002875)2.03502524
103Type 2 muscle fiber atrophy (HP:0003554)2.03107036
104Renal cortical cysts (HP:0000803)2.01561410
105Medulloblastoma (HP:0002885)2.00158506
106Testicular atrophy (HP:0000029)1.99183948
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97991528
108Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97991528
109Sloping forehead (HP:0000340)1.97863069
110Azoospermia (HP:0000027)1.97750426
111Embryonal renal neoplasm (HP:0011794)1.97716182
112Abnormality of the pons (HP:0007361)1.97230001
113Mitochondrial inheritance (HP:0001427)1.97173650
114Tracheoesophageal fistula (HP:0002575)1.95951951
115Short thumb (HP:0009778)1.95829807
116True hermaphroditism (HP:0010459)1.95470438
117Cellular immunodeficiency (HP:0005374)1.95044163
118Lymphoma (HP:0002665)1.94405969
119Degeneration of anterior horn cells (HP:0002398)1.93171658
120Abnormality of the anterior horn cell (HP:0006802)1.93171658
121Emotional lability (HP:0000712)1.92291728
122Supernumerary spleens (HP:0009799)1.91689898
123Stomach cancer (HP:0012126)1.91594822
124Megaloblastic anemia (HP:0001889)1.90861487
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90844394
126Dicarboxylic aciduria (HP:0003215)1.90844394
127Microvesicular hepatic steatosis (HP:0001414)1.88855702
128Hyperglycinemia (HP:0002154)1.88534616
129Facial cleft (HP:0002006)1.86692032
130Aplasia/hypoplasia of the uterus (HP:0008684)1.85471580
131Preaxial hand polydactyly (HP:0001177)1.84984737
132IgM deficiency (HP:0002850)1.84967824
133Patchy hypopigmentation of hair (HP:0011365)1.84421256
134Hypoplasia of the pons (HP:0012110)1.83186402
135Sensory axonal neuropathy (HP:0003390)1.83181402
136Hepatocellular necrosis (HP:0001404)1.81521158
137Hepatic necrosis (HP:0002605)1.81149319
138Conical tooth (HP:0000698)1.80812482
139Abnormal mitochondria in muscle tissue (HP:0008316)1.77769703
140Congenital, generalized hypertrichosis (HP:0004540)1.77264444
141Abnormality of renal resorption (HP:0011038)1.77087709
142Hypergonadotropic hypogonadism (HP:0000815)1.76661755
143Premature ovarian failure (HP:0008209)1.75820033
144Cleft eyelid (HP:0000625)1.75573381
145Opisthotonus (HP:0002179)1.72882986
146Blindness (HP:0000618)1.71756771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.40207133
2VRK24.30992020
3BUB13.84991869
4NME23.73815836
5EIF2AK13.56447088
6WEE13.54465567
7MST43.24501467
8SRPK13.13529954
9MKNK13.02745270
10VRK12.82341761
11NEK12.77288262
12CDC72.67886031
13PLK42.52672371
14EIF2AK32.38851273
15ZAK2.21288519
16IRAK42.20989830
17MKNK22.13342970
18IRAK31.84109577
19TTK1.82669612
20TRIM281.74621497
21EIF2AK21.67160558
22TLK11.63287019
23PLK11.62588107
24CDK71.60012920
25BRSK21.53508357
26ATR1.51981570
27BMPR1B1.51583002
28PDK21.51055077
29PLK31.50348148
30CDK81.33534060
31CHEK21.33115701
32AKT31.30139622
33SCYL21.28756982
34NEK21.28294992
35MAP4K21.26984581
36MAP3K121.26187592
37TSSK61.25691157
38AURKB1.25007724
39ACVR1B1.21958078
40MUSK1.21375162
41PBK1.15349779
42BRAF1.15176930
43WNK31.12089394
44PIM21.07218044
45TAF11.05841549
46DYRK31.05548861
47DYRK21.01325509
48EPHA20.98563458
49NME10.94095666
50PAK40.93180148
51CHEK10.93101151
52AURKA0.92813003
53TXK0.91885060
54BRSK10.90385866
55MAPKAPK50.89324616
56STK38L0.88076836
57RPS6KA50.87270273
58CDK40.85900084
59NEK60.85847879
60DAPK10.85063371
61MAPK130.83085697
62CCNB10.81190818
63PASK0.79334367
64CDK30.78517401
65CSNK1G30.77836784
66SIK30.77057390
67YES10.76248626
68TEC0.75683191
69TAOK20.74994459
70CLK10.74726200
71CSNK2A10.73730414
72PINK10.73641996
73CDK120.73398275
74ATM0.73038481
75ADRBK20.72090534
76CSNK1G10.72031354
77PRKCI0.70875998
78TAOK30.69011808
79STK40.67263710
80RPS6KA40.67071282
81CSNK2A20.66085820
82CSNK1A1L0.63919874
83CDK20.62379192
84RPS6KB20.60751649
85CDK190.60680678
86ERBB40.59057313
87PLK20.58834144
88CASK0.57731536
89PIM10.56279213
90CSNK1G20.54236486
91OXSR10.53750644
92CDK10.52492065
93MAP3K80.51332722
94MAP3K60.51014761
95TGFBR10.50716823
96MAP2K30.50243532
97TNIK0.49997311
98ERBB30.49453180
99ALK0.47392478
100BCR0.46503570
101MAP2K60.43799988
102TNK20.42075159
103TIE10.41194387
104MYLK0.40914732
105NUAK10.38633271
106STK390.37748652
107LIMK10.37565341
108FLT30.35848253
109NLK0.34436250
110GRK10.32722220
111IRAK20.31465230
112IRAK10.31429341
113LYN0.30623243
114TGFBR20.30419746
115ILK0.30320713
116TESK10.30213811
117BMPR20.29787384
118INSRR0.29211871
119KIT0.28465834
120BRD40.28424513
121MAP3K30.27413595
122TESK20.27257474
123ABL20.27049907
124ARAF0.26908772
125MAPK140.26282231
126BCKDK0.25822710
127STK100.25457340
128KDR0.25121258
129IKBKB0.24398835
130PAK10.24237850
131CSNK1E0.23327754
132PNCK0.22404975

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54111877
2RNA polymerase_Homo sapiens_hsa030203.94494144
3Mismatch repair_Homo sapiens_hsa034303.91299724
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80650428
5Proteasome_Homo sapiens_hsa030503.65556539
6Ribosome_Homo sapiens_hsa030103.58845650
7Homologous recombination_Homo sapiens_hsa034403.42831042
8Spliceosome_Homo sapiens_hsa030403.13654457
9Fanconi anemia pathway_Homo sapiens_hsa034602.86524444
10Pyrimidine metabolism_Homo sapiens_hsa002402.86027676
11Base excision repair_Homo sapiens_hsa034102.72501743
12Nucleotide excision repair_Homo sapiens_hsa034202.71106012
13* RNA transport_Homo sapiens_hsa030132.66581615
14Basal transcription factors_Homo sapiens_hsa030222.50068093
15One carbon pool by folate_Homo sapiens_hsa006702.30497941
16Cell cycle_Homo sapiens_hsa041102.18851804
17Non-homologous end-joining_Homo sapiens_hsa034502.12883204
18RNA degradation_Homo sapiens_hsa030181.95994780
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83576527
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76197568
21Purine metabolism_Homo sapiens_hsa002301.73706810
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59462369
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50214612
24Propanoate metabolism_Homo sapiens_hsa006401.42072457
25mRNA surveillance pathway_Homo sapiens_hsa030151.37102928
26Pyruvate metabolism_Homo sapiens_hsa006201.26418203
27p53 signaling pathway_Homo sapiens_hsa041151.22174325
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15411787
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13964598
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13731338
31Folate biosynthesis_Homo sapiens_hsa007901.13264485
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10374308
33Vitamin B6 metabolism_Homo sapiens_hsa007501.10259209
34Protein export_Homo sapiens_hsa030601.07259155
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06660717
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.05290590
37Parkinsons disease_Homo sapiens_hsa050121.04889015
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.03658101
39Huntingtons disease_Homo sapiens_hsa050161.02192500
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01836308
41Epstein-Barr virus infection_Homo sapiens_hsa051690.98126048
42Carbon metabolism_Homo sapiens_hsa012000.97410136
43Oxidative phosphorylation_Homo sapiens_hsa001900.96620299
44Herpes simplex infection_Homo sapiens_hsa051680.87584377
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87209122
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85067666
47Cardiac muscle contraction_Homo sapiens_hsa042600.82108771
48Arachidonic acid metabolism_Homo sapiens_hsa005900.81646566
49Systemic lupus erythematosus_Homo sapiens_hsa053220.80707243
50Glutathione metabolism_Homo sapiens_hsa004800.80310467
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.76099070
52Sulfur relay system_Homo sapiens_hsa041220.74216130
53Sulfur metabolism_Homo sapiens_hsa009200.70717593
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69051722
55Asthma_Homo sapiens_hsa053100.65923092
56Peroxisome_Homo sapiens_hsa041460.65192557
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64263191
58Vitamin digestion and absorption_Homo sapiens_hsa049770.55796517
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54066527
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54050368
61Metabolic pathways_Homo sapiens_hsa011000.52009723
62Fatty acid degradation_Homo sapiens_hsa000710.51160280
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49538707
64Butanoate metabolism_Homo sapiens_hsa006500.48493254
65Linoleic acid metabolism_Homo sapiens_hsa005910.46881961
66Regulation of autophagy_Homo sapiens_hsa041400.45621901
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45225460
68Tryptophan metabolism_Homo sapiens_hsa003800.43738773
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43156850
70Fatty acid metabolism_Homo sapiens_hsa012120.42728207
71Alzheimers disease_Homo sapiens_hsa050100.42347884
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38745745
73Viral carcinogenesis_Homo sapiens_hsa052030.38519888
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37581769
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37118494
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.36678630
77Measles_Homo sapiens_hsa051620.36582460
78Pentose phosphate pathway_Homo sapiens_hsa000300.36580327
79Oocyte meiosis_Homo sapiens_hsa041140.36015402
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.35965434
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35935858
82Hematopoietic cell lineage_Homo sapiens_hsa046400.34123872
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.34008119
84Retinol metabolism_Homo sapiens_hsa008300.33762665
85Autoimmune thyroid disease_Homo sapiens_hsa053200.31639339
86Primary immunodeficiency_Homo sapiens_hsa053400.31350261
87Collecting duct acid secretion_Homo sapiens_hsa049660.30296054
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28841086
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28802491
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28356342
91HTLV-I infection_Homo sapiens_hsa051660.27898486
92Arginine and proline metabolism_Homo sapiens_hsa003300.27559802
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27465921
94beta-Alanine metabolism_Homo sapiens_hsa004100.26653420
95Sphingolipid metabolism_Homo sapiens_hsa006000.26039862
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24650354
97Selenocompound metabolism_Homo sapiens_hsa004500.24210981
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23951448
99Chemical carcinogenesis_Homo sapiens_hsa052040.23934578
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23485050
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23206672
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.22682034
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22528821
104Caffeine metabolism_Homo sapiens_hsa002320.21493196
105Nitrogen metabolism_Homo sapiens_hsa009100.21327114
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21050830
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20196854
108Antigen processing and presentation_Homo sapiens_hsa046120.20036206
109Influenza A_Homo sapiens_hsa051640.19608876
110Fatty acid elongation_Homo sapiens_hsa000620.19426833
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19340915
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19333888
113Thyroid cancer_Homo sapiens_hsa052160.19169129
114Tyrosine metabolism_Homo sapiens_hsa003500.18280483
115Other glycan degradation_Homo sapiens_hsa005110.17988197
116Steroid biosynthesis_Homo sapiens_hsa001000.17923072
117Allograft rejection_Homo sapiens_hsa053300.17337709
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16518130
119Type I diabetes mellitus_Homo sapiens_hsa049400.16509992
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15970077
121Phototransduction_Homo sapiens_hsa047440.15804890
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15480810
123Fat digestion and absorption_Homo sapiens_hsa049750.14482971
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12629910
125N-Glycan biosynthesis_Homo sapiens_hsa005100.12469433
126Alcoholism_Homo sapiens_hsa050340.12023951
127Biosynthesis of amino acids_Homo sapiens_hsa012300.11152451
128Small cell lung cancer_Homo sapiens_hsa052220.10575334

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