Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.14993907 |
2 | kinetochore assembly (GO:0051382) | 4.97451456 |
3 | chaperone-mediated protein transport (GO:0072321) | 4.92490992 |
4 | kinetochore organization (GO:0051383) | 4.80516555 |
5 | proteasome assembly (GO:0043248) | 4.79664748 |
6 | DNA deamination (GO:0045006) | 4.73961823 |
7 | mitotic metaphase plate congression (GO:0007080) | 4.70750395 |
8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.52933720 |
9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.50340380 |
10 | ATP synthesis coupled proton transport (GO:0015986) | 4.50340380 |
11 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.48753943 |
12 | DNA replication initiation (GO:0006270) | 4.40805102 |
13 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.35636835 |
14 | negative regulation of ligase activity (GO:0051352) | 4.35636835 |
15 | purine nucleobase biosynthetic process (GO:0009113) | 4.23792922 |
16 | CENP-A containing nucleosome assembly (GO:0034080) | 4.23680966 |
17 | ribosome biogenesis (GO:0042254) | 4.17880093 |
18 | chromatin remodeling at centromere (GO:0031055) | 4.17687657 |
19 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.16634342 |
20 | DNA replication checkpoint (GO:0000076) | 4.09533171 |
21 | nucleobase biosynthetic process (GO:0046112) | 4.09219802 |
22 | DNA strand elongation (GO:0022616) | 4.06022771 |
23 | telomere maintenance via recombination (GO:0000722) | 4.03802136 |
24 | ribosomal small subunit assembly (GO:0000028) | 4.00533091 |
25 | ribosomal large subunit biogenesis (GO:0042273) | 3.95712298 |
26 | maturation of SSU-rRNA (GO:0030490) | 3.93524000 |
27 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.92335879 |
28 | cullin deneddylation (GO:0010388) | 3.92108074 |
29 | metaphase plate congression (GO:0051310) | 3.91672578 |
30 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.90361220 |
31 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.81186597 |
32 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.81186597 |
33 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.80831718 |
34 | pseudouridine synthesis (GO:0001522) | 3.79830369 |
35 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.79820423 |
36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.78282067 |
37 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.77780960 |
38 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.77572752 |
39 | rRNA modification (GO:0000154) | 3.76415940 |
40 | protein complex biogenesis (GO:0070271) | 3.76175435 |
41 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.74593920 |
42 | telomere maintenance via telomere lengthening (GO:0010833) | 3.74145064 |
43 | respiratory electron transport chain (GO:0022904) | 3.72751281 |
44 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.71764730 |
45 | termination of RNA polymerase III transcription (GO:0006386) | 3.71764730 |
46 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.70712447 |
47 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.70712447 |
48 | NADH dehydrogenase complex assembly (GO:0010257) | 3.70712447 |
49 | mitotic recombination (GO:0006312) | 3.70689369 |
50 | protein deneddylation (GO:0000338) | 3.70602260 |
51 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.69985744 |
52 | positive regulation of ligase activity (GO:0051351) | 3.66030346 |
53 | 7-methylguanosine mRNA capping (GO:0006370) | 3.64748435 |
54 | electron transport chain (GO:0022900) | 3.64267641 |
55 | rRNA processing (GO:0006364) | 3.63505681 |
56 | ribosome assembly (GO:0042255) | 3.63342606 |
57 | protein targeting to mitochondrion (GO:0006626) | 3.61773119 |
58 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.60513588 |
59 | DNA replication-independent nucleosome organization (GO:0034724) | 3.60513588 |
60 | RNA capping (GO:0036260) | 3.59894161 |
61 | 7-methylguanosine RNA capping (GO:0009452) | 3.59894161 |
62 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.57414309 |
63 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.57414309 |
64 | IMP biosynthetic process (GO:0006188) | 3.55779661 |
65 | rRNA metabolic process (GO:0016072) | 3.53205187 |
66 | spliceosomal snRNP assembly (GO:0000387) | 3.50775596 |
67 | tRNA methylation (GO:0030488) | 3.49257551 |
68 | termination of RNA polymerase I transcription (GO:0006363) | 3.48309482 |
69 | respiratory chain complex IV assembly (GO:0008535) | 3.48043776 |
70 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.43829961 |
71 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.42628467 |
72 | protein K6-linked ubiquitination (GO:0085020) | 3.40723663 |
73 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.40529626 |
74 | protein localization to mitochondrion (GO:0070585) | 3.39419708 |
75 | translation (GO:0006412) | 3.39408787 |
76 | histone exchange (GO:0043486) | 3.38761532 |
77 | meiotic chromosome segregation (GO:0045132) | 3.38695099 |
78 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.38597309 |
79 | ribosomal small subunit biogenesis (GO:0042274) | 3.37814144 |
80 | transcription from RNA polymerase I promoter (GO:0006360) | 3.35995586 |
81 | DNA double-strand break processing (GO:0000729) | 3.35828176 |
82 | establishment of chromosome localization (GO:0051303) | 3.34642412 |
83 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.34272332 |
84 | regulation of ligase activity (GO:0051340) | 3.32970933 |
85 | intra-S DNA damage checkpoint (GO:0031573) | 3.32691461 |
86 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.31277872 |
87 | establishment of protein localization to mitochondrion (GO:0072655) | 3.30940615 |
88 | DNA damage response, detection of DNA damage (GO:0042769) | 3.29234045 |
89 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.29228894 |
90 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.29029424 |
91 | maturation of 5.8S rRNA (GO:0000460) | 3.25245632 |
92 | protein neddylation (GO:0045116) | 3.24266598 |
93 | cytochrome complex assembly (GO:0017004) | 3.18879420 |
94 | establishment of viral latency (GO:0019043) | 3.17499413 |
95 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.17269903 |
96 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.16918784 |
97 | cellular component biogenesis (GO:0044085) | 3.15493117 |
98 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.14729622 |
99 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14702045 |
100 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.13839518 |
101 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12055508 |
102 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.12048452 |
103 | rRNA methylation (GO:0031167) | 3.09873979 |
104 | histone mRNA metabolic process (GO:0008334) | 3.09232046 |
105 | establishment of integrated proviral latency (GO:0075713) | 3.08741861 |
106 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.08430435 |
107 | protein localization to kinetochore (GO:0034501) | 3.07234963 |
108 | negative regulation of protein ubiquitination (GO:0031397) | 3.06615689 |
109 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.05601816 |
110 | telomere organization (GO:0032200) | 3.04231472 |
111 | telomere maintenance (GO:0000723) | 3.03593081 |
112 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.02419771 |
113 | oxidative phosphorylation (GO:0006119) | 3.02347475 |
114 | regulation of cellular amine metabolic process (GO:0033238) | 3.02111212 |
115 | * ncRNA processing (GO:0034470) | 3.01457375 |
116 | tRNA modification (GO:0006400) | 3.01165942 |
117 | DNA ligation (GO:0006266) | 3.00715982 |
118 | replication fork processing (GO:0031297) | 3.00510441 |
119 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.99258054 |
120 | formation of translation preinitiation complex (GO:0001731) | 2.98803793 |
121 | viral mRNA export from host cell nucleus (GO:0046784) | 2.97694130 |
122 | regulation of mitochondrial translation (GO:0070129) | 2.95816504 |
123 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.95624144 |
124 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.95352742 |
125 | mitotic nuclear envelope disassembly (GO:0007077) | 2.93285076 |
126 | mismatch repair (GO:0006298) | 2.92368566 |
127 | mitochondrial RNA metabolic process (GO:0000959) | 2.90461363 |
128 | * ncRNA metabolic process (GO:0034660) | 2.90098458 |
129 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.89973766 |
130 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.89973766 |
131 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.89973766 |
132 | viral transcription (GO:0019083) | 2.89561942 |
133 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.89132864 |
134 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.88895310 |
135 | nuclear pore organization (GO:0006999) | 2.88850616 |
136 | DNA-templated transcription, termination (GO:0006353) | 2.88716559 |
137 | cell cycle G1/S phase transition (GO:0044843) | 2.88715825 |
138 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.88715825 |
139 | translational termination (GO:0006415) | 2.87405238 |
140 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.86894006 |
141 | spliceosomal complex assembly (GO:0000245) | 2.86289215 |
142 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.85391443 |
143 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.85391443 |
144 | protein localization to chromosome, centromeric region (GO:0071459) | 2.84993605 |
145 | isotype switching (GO:0045190) | 2.84813438 |
146 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.84813438 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.41645324 |
2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.47841285 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.16046669 |
4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.75153201 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.43727424 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.20154950 |
7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.17217698 |
8 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.08206025 |
9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.01936302 |
10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.95086048 |
11 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.89947655 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.89399248 |
13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88507349 |
14 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.86670740 |
15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.78184301 |
16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.71845900 |
17 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.70146880 |
18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.69243386 |
19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.66363990 |
20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.66227537 |
21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.56292065 |
22 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.52902798 |
23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.50397242 |
24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.44980055 |
25 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.30528906 |
26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.26934126 |
27 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.14928663 |
28 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.12183356 |
29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.10750774 |
30 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.08947982 |
31 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.05128433 |
32 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.00432580 |
33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.98385425 |
34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.98359065 |
35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.96714423 |
36 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.96103368 |
37 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.96072381 |
38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.93837550 |
39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.93627425 |
40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.86773132 |
41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.85631295 |
42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.79967832 |
43 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.76102690 |
44 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.71331565 |
45 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.70566028 |
46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.69946392 |
47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.68233693 |
48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.68113848 |
49 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.68034830 |
50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.66262229 |
51 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.60465353 |
52 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57844863 |
53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.52156078 |
54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.51741679 |
55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37774506 |
56 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.36660325 |
57 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.35955326 |
58 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.33242864 |
59 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32116920 |
60 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.31608136 |
61 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.27141260 |
62 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.24829657 |
63 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22367545 |
64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.22217195 |
65 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.21288473 |
66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18307526 |
67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.17652259 |
68 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.16429045 |
69 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.11790096 |
70 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.09110606 |
71 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.08148032 |
72 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.05674573 |
73 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.96015704 |
74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.95477558 |
75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.94649329 |
76 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.94443884 |
77 | * ZNF274_21170338_ChIP-Seq_K562_Hela | 0.91983696 |
78 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.91370945 |
79 | VDR_22108803_ChIP-Seq_LS180_Human | 0.91221999 |
80 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90484661 |
81 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.88968022 |
82 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.88586875 |
83 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.88247693 |
84 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.86465257 |
85 | FUS_26573619_Chip-Seq_HEK293_Human | 0.85170567 |
86 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.84235835 |
87 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83620940 |
88 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.82987848 |
89 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.81900807 |
90 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.80001972 |
91 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.78604034 |
92 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.76041839 |
93 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.74858826 |
94 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.74684076 |
95 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.74414540 |
96 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74177078 |
97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.72440466 |
98 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.71893902 |
99 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.71671146 |
100 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.71584969 |
101 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.71532409 |
102 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.70569779 |
103 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.68361398 |
104 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.68325615 |
105 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.65089173 |
106 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64508248 |
107 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.63912345 |
108 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.63677803 |
109 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.63589746 |
110 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.63579682 |
111 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.63467592 |
112 | * EWS_26573619_Chip-Seq_HEK293_Human | 0.61576501 |
113 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.61316816 |
114 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.60830611 |
115 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.59973084 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 5.11492988 |
2 | MP0008057_abnormal_DNA_replication | 4.47872291 |
3 | MP0010094_abnormal_chromosome_stability | 4.06748290 |
4 | MP0008058_abnormal_DNA_repair | 4.05497298 |
5 | MP0003111_abnormal_nucleus_morphology | 3.90852926 |
6 | MP0004957_abnormal_blastocyst_morpholog | 3.32104340 |
7 | MP0003077_abnormal_cell_cycle | 3.28935473 |
8 | MP0006292_abnormal_olfactory_placode | 3.07317553 |
9 | MP0003136_yellow_coat_color | 2.95296688 |
10 | MP0008007_abnormal_cellular_replicative | 2.87287836 |
11 | MP0002396_abnormal_hematopoietic_system | 2.72294847 |
12 | MP0000566_synostosis | 2.68342450 |
13 | MP0001188_hyperpigmentation | 2.64959532 |
14 | MP0008877_abnormal_DNA_methylation | 2.58339263 |
15 | MP0003718_maternal_effect | 2.43396744 |
16 | MP0008932_abnormal_embryonic_tissue | 2.31418023 |
17 | MP0003786_premature_aging | 2.18886393 |
18 | MP0006035_abnormal_mitochondrial_morpho | 2.02946985 |
19 | MP0002102_abnormal_ear_morphology | 2.00830920 |
20 | MP0003123_paternal_imprinting | 1.81803403 |
21 | MP0006072_abnormal_retinal_apoptosis | 1.68041524 |
22 | MP0009379_abnormal_foot_pigmentation | 1.66675751 |
23 | MP0004381_abnormal_hair_follicle | 1.60129009 |
24 | MP0003941_abnormal_skin_development | 1.59526559 |
25 | MP0002277_abnormal_respiratory_mucosa | 1.58932217 |
26 | MP0003315_abnormal_perineum_morphology | 1.52127753 |
27 | MP0002210_abnormal_sex_determination | 1.51517049 |
28 | MP0009697_abnormal_copulation | 1.49537943 |
29 | MP0002132_abnormal_respiratory_system | 1.46582014 |
30 | MP0005075_abnormal_melanosome_morpholog | 1.46333120 |
31 | MP0001853_heart_inflammation | 1.41483812 |
32 | MP0000350_abnormal_cell_proliferation | 1.39106079 |
33 | MP0000490_abnormal_crypts_of | 1.38137452 |
34 | MP0003186_abnormal_redox_activity | 1.37758962 |
35 | MP0002638_abnormal_pupillary_reflex | 1.34531038 |
36 | MP0000358_abnormal_cell_content/ | 1.31792263 |
37 | MP0001730_embryonic_growth_arrest | 1.30905591 |
38 | MP0002736_abnormal_nociception_after | 1.29573758 |
39 | MP0003890_abnormal_embryonic-extraembry | 1.29378456 |
40 | MP0002160_abnormal_reproductive_system | 1.28647452 |
41 | MP0001986_abnormal_taste_sensitivity | 1.28312218 |
42 | MP0002163_abnormal_gland_morphology | 1.27334449 |
43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.24222579 |
44 | MP0003121_genomic_imprinting | 1.23636082 |
45 | MP0010030_abnormal_orbit_morphology | 1.22851635 |
46 | MP0008875_abnormal_xenobiotic_pharmacok | 1.20488617 |
47 | MP0005451_abnormal_body_composition | 1.20143286 |
48 | MP0002938_white_spotting | 1.17365121 |
49 | MP0001145_abnormal_male_reproductive | 1.15477514 |
50 | MP0003950_abnormal_plasma_membrane | 1.13881061 |
51 | MP0008789_abnormal_olfactory_epithelium | 1.13003120 |
52 | MP0003806_abnormal_nucleotide_metabolis | 1.11049311 |
53 | MP0005084_abnormal_gallbladder_morpholo | 1.09000845 |
54 | MP0000313_abnormal_cell_death | 1.08735712 |
55 | MP0008872_abnormal_physiological_respon | 1.08257710 |
56 | MP0005380_embryogenesis_phenotype | 1.06304638 |
57 | MP0001672_abnormal_embryogenesis/_devel | 1.06304638 |
58 | MP0005389_reproductive_system_phenotype | 1.05964011 |
59 | MP0002095_abnormal_skin_pigmentation | 1.05264720 |
60 | MP0001529_abnormal_vocalization | 1.04994769 |
61 | MP0000653_abnormal_sex_gland | 1.03848991 |
62 | MP0005409_darkened_coat_color | 1.03730079 |
63 | MP0001881_abnormal_mammary_gland | 1.03707587 |
64 | MP0003787_abnormal_imprinting | 1.03537239 |
65 | MP0001929_abnormal_gametogenesis | 1.03442257 |
66 | MP0008995_early_reproductive_senescence | 1.02427155 |
67 | MP0001293_anophthalmia | 1.00275833 |
68 | MP0000015_abnormal_ear_pigmentation | 0.98309408 |
69 | MP0001119_abnormal_female_reproductive | 0.96900919 |
70 | MP0004147_increased_porphyrin_level | 0.95926927 |
71 | MP0002249_abnormal_larynx_morphology | 0.92247484 |
72 | MP0002019_abnormal_tumor_incidence | 0.89701349 |
73 | MP0003938_abnormal_ear_development | 0.88923597 |
74 | MP0001697_abnormal_embryo_size | 0.87396113 |
75 | MP0001764_abnormal_homeostasis | 0.87219786 |
76 | MP0001919_abnormal_reproductive_system | 0.86320439 |
77 | MP0004808_abnormal_hematopoietic_stem | 0.85834193 |
78 | MP0005410_abnormal_fertilization | 0.84822034 |
79 | MP0000613_abnormal_salivary_gland | 0.84645261 |
80 | MP0003984_embryonic_growth_retardation | 0.82567217 |
81 | MP0000516_abnormal_urinary_system | 0.82433605 |
82 | MP0005367_renal/urinary_system_phenotyp | 0.82433605 |
83 | MP0005397_hematopoietic_system_phenotyp | 0.81573049 |
84 | MP0001545_abnormal_hematopoietic_system | 0.81573049 |
85 | MP0002085_abnormal_embryonic_tissue | 0.81355855 |
86 | MP0008873_increased_physiological_sensi | 0.80139322 |
87 | MP0003763_abnormal_thymus_physiology | 0.79661002 |
88 | MP0001286_abnormal_eye_development | 0.79279948 |
89 | MP0000372_irregular_coat_pigmentation | 0.78959165 |
90 | MP0002088_abnormal_embryonic_growth/wei | 0.77674478 |
91 | MP0006036_abnormal_mitochondrial_physio | 0.76649683 |
92 | MP0003011_delayed_dark_adaptation | 0.75562379 |
93 | MP0001485_abnormal_pinna_reflex | 0.75516528 |
94 | MP0005174_abnormal_tail_pigmentation | 0.74534329 |
95 | MP0003937_abnormal_limbs/digits/tail_de | 0.74479389 |
96 | MP0002080_prenatal_lethality | 0.73940913 |
97 | MP0001186_pigmentation_phenotype | 0.72523621 |
98 | MP0005253_abnormal_eye_physiology | 0.71547786 |
99 | MP0005499_abnormal_olfactory_system | 0.70463534 |
100 | MP0005394_taste/olfaction_phenotype | 0.70463534 |
101 | MP0005501_abnormal_skin_physiology | 0.70457017 |
102 | MP0003221_abnormal_cardiomyocyte_apopto | 0.68621188 |
103 | MP0001727_abnormal_embryo_implantation | 0.68488481 |
104 | MP0005379_endocrine/exocrine_gland_phen | 0.67826751 |
105 | MP0001968_abnormal_touch/_nociception | 0.67254099 |
106 | MP0002233_abnormal_nose_morphology | 0.67220010 |
107 | MP0005332_abnormal_amino_acid | 0.67148936 |
108 | MP0005395_other_phenotype | 0.66450853 |
109 | MP0001346_abnormal_lacrimal_gland | 0.66166655 |
110 | MP0004215_abnormal_myocardial_fiber | 0.65589322 |
111 | MP0009333_abnormal_splenocyte_physiolog | 0.64609504 |
112 | MP0005266_abnormal_metabolism | 0.64387157 |
113 | MP0001905_abnormal_dopamine_level | 0.64104124 |
114 | MP0005551_abnormal_eye_electrophysiolog | 0.63785826 |
115 | MP0003698_abnormal_male_reproductive | 0.63754844 |
116 | MP0008260_abnormal_autophagy | 0.63739645 |
117 | MP0005645_abnormal_hypothalamus_physiol | 0.63470154 |
118 | MP0004782_abnormal_surfactant_physiolog | 0.62551750 |
119 | MP0005646_abnormal_pituitary_gland | 0.61953148 |
120 | MP0003936_abnormal_reproductive_system | 0.61840579 |
121 | MP0005636_abnormal_mineral_homeostasis | 0.61572783 |
122 | MP0002111_abnormal_tail_morphology | 0.61189795 |
123 | MP0003195_calcinosis | 0.59134005 |
124 | MP0003252_abnormal_bile_duct | 0.59114911 |
125 | MP0002086_abnormal_extraembryonic_tissu | 0.58725758 |
126 | MP0005408_hypopigmentation | 0.57328074 |
127 | MP0000049_abnormal_middle_ear | 0.56860201 |
128 | MP0002084_abnormal_developmental_patter | 0.55606317 |
129 | MP0000703_abnormal_thymus_morphology | 0.55097831 |
130 | MP0000689_abnormal_spleen_morphology | 0.54746595 |
131 | MP0000647_abnormal_sebaceous_gland | 0.54421145 |
132 | MP0002090_abnormal_vision | 0.54203385 |
133 | MP0010307_abnormal_tumor_latency | 0.52594375 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 5.51949244 |
2 | Chromsome breakage (HP:0040012) | 5.31015381 |
3 | Birth length less than 3rd percentile (HP:0003561) | 5.09482993 |
4 | Acute encephalopathy (HP:0006846) | 4.94454407 |
5 | Progressive macrocephaly (HP:0004481) | 4.39218704 |
6 | Reticulocytopenia (HP:0001896) | 4.29980991 |
7 | Cerebral edema (HP:0002181) | 3.74334606 |
8 | Breast hypoplasia (HP:0003187) | 3.73710659 |
9 | Abnormality of the preputium (HP:0100587) | 3.58149647 |
10 | Duplicated collecting system (HP:0000081) | 3.51022952 |
11 | Abnormality of chromosome stability (HP:0003220) | 3.31404429 |
12 | Meckel diverticulum (HP:0002245) | 3.28915136 |
13 | Abnormal number of erythroid precursors (HP:0012131) | 3.27337846 |
14 | Lactic acidosis (HP:0003128) | 3.21083029 |
15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.18690310 |
16 | Abnormality of the renal collecting system (HP:0004742) | 3.15787338 |
17 | Abnormality of the ileum (HP:0001549) | 3.15629147 |
18 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.01708717 |
19 | Increased serum pyruvate (HP:0003542) | 2.99414161 |
20 | Patellar aplasia (HP:0006443) | 2.98752069 |
21 | Rough bone trabeculation (HP:0100670) | 2.97015935 |
22 | Oral leukoplakia (HP:0002745) | 2.93218147 |
23 | Aplastic anemia (HP:0001915) | 2.89393698 |
24 | Reduced antithrombin III activity (HP:0001976) | 2.87833489 |
25 | Respiratory failure (HP:0002878) | 2.87666014 |
26 | Renal Fanconi syndrome (HP:0001994) | 2.87585802 |
27 | Increased intramyocellular lipid droplets (HP:0012240) | 2.86685398 |
28 | Abnormal protein glycosylation (HP:0012346) | 2.83423751 |
29 | Abnormal glycosylation (HP:0012345) | 2.83423751 |
30 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.83423751 |
31 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.83423751 |
32 | Premature graying of hair (HP:0002216) | 2.80178744 |
33 | Colon cancer (HP:0003003) | 2.78792036 |
34 | Exercise intolerance (HP:0003546) | 2.77905506 |
35 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.75250611 |
36 | Abnormality of glycolysis (HP:0004366) | 2.73728571 |
37 | 3-Methylglutaconic aciduria (HP:0003535) | 2.67368780 |
38 | Macrocytic anemia (HP:0001972) | 2.65785451 |
39 | Leukodystrophy (HP:0002415) | 2.65608571 |
40 | Ectopic kidney (HP:0000086) | 2.63747706 |
41 | Impulsivity (HP:0100710) | 2.63186546 |
42 | Increased hepatocellular lipid droplets (HP:0006565) | 2.61954489 |
43 | Abnormality of methionine metabolism (HP:0010901) | 2.61008718 |
44 | Abnormal trabecular bone morphology (HP:0100671) | 2.59360288 |
45 | Bone marrow hypocellularity (HP:0005528) | 2.58465808 |
46 | Absent thumb (HP:0009777) | 2.56421070 |
47 | Small intestinal stenosis (HP:0012848) | 2.56194962 |
48 | Duodenal stenosis (HP:0100867) | 2.56194962 |
49 | Abnormality of the labia minora (HP:0012880) | 2.56136475 |
50 | Absent radius (HP:0003974) | 2.55068776 |
51 | Lethargy (HP:0001254) | 2.52838690 |
52 | Pancytopenia (HP:0001876) | 2.51061743 |
53 | Pallor (HP:0000980) | 2.47572231 |
54 | Abnormality of alanine metabolism (HP:0010916) | 2.46745515 |
55 | Hyperalaninemia (HP:0003348) | 2.46745515 |
56 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.46745515 |
57 | Triphalangeal thumb (HP:0001199) | 2.46459532 |
58 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.43701497 |
59 | Horseshoe kidney (HP:0000085) | 2.42347656 |
60 | Abnormal spermatogenesis (HP:0008669) | 2.41088511 |
61 | Methylmalonic acidemia (HP:0002912) | 2.40160786 |
62 | Optic disc pallor (HP:0000543) | 2.38369343 |
63 | Methylmalonic aciduria (HP:0012120) | 2.37133497 |
64 | Aplasia involving forearm bones (HP:0009822) | 2.35887286 |
65 | Absent forearm bone (HP:0003953) | 2.35887286 |
66 | Myelodysplasia (HP:0002863) | 2.33404427 |
67 | Increased muscle lipid content (HP:0009058) | 2.33267047 |
68 | Carpal bone hypoplasia (HP:0001498) | 2.33111926 |
69 | Multiple enchondromatosis (HP:0005701) | 2.31475041 |
70 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.29798188 |
71 | Abnormality of serum amino acid levels (HP:0003112) | 2.27762415 |
72 | CNS demyelination (HP:0007305) | 2.26949406 |
73 | Abnormality of DNA repair (HP:0003254) | 2.25736994 |
74 | Clubbing of toes (HP:0100760) | 2.24564482 |
75 | Sparse eyelashes (HP:0000653) | 2.23910401 |
76 | Pancreatic cysts (HP:0001737) | 2.19785273 |
77 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.18498800 |
78 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.17939179 |
79 | Microretrognathia (HP:0000308) | 2.17929844 |
80 | Acute necrotizing encephalopathy (HP:0006965) | 2.14208745 |
81 | Abnormal lung lobation (HP:0002101) | 2.14154816 |
82 | Abnormality of the duodenum (HP:0002246) | 2.14090382 |
83 | Lipid accumulation in hepatocytes (HP:0006561) | 2.13356732 |
84 | Pancreatic fibrosis (HP:0100732) | 2.12148235 |
85 | Type I transferrin isoform profile (HP:0003642) | 2.11274809 |
86 | Prostate neoplasm (HP:0100787) | 2.11169042 |
87 | Increased serum lactate (HP:0002151) | 2.10180039 |
88 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.09637229 |
89 | Respiratory difficulties (HP:0002880) | 2.08563175 |
90 | Generalized aminoaciduria (HP:0002909) | 2.07453852 |
91 | Abnormality of midbrain morphology (HP:0002418) | 2.07358941 |
92 | Molar tooth sign on MRI (HP:0002419) | 2.07358941 |
93 | Duplication of thumb phalanx (HP:0009942) | 2.06817738 |
94 | Abnormality of placental membranes (HP:0011409) | 2.06310512 |
95 | Amniotic constriction ring (HP:0009775) | 2.06310512 |
96 | Increased CSF lactate (HP:0002490) | 2.05959871 |
97 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.05379332 |
98 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.05047139 |
99 | Cerebral hypomyelination (HP:0006808) | 2.04368620 |
100 | Muscle fiber atrophy (HP:0100295) | 2.04199150 |
101 | Ureteral duplication (HP:0000073) | 2.03817452 |
102 | Exertional dyspnea (HP:0002875) | 2.03502524 |
103 | Type 2 muscle fiber atrophy (HP:0003554) | 2.03107036 |
104 | Renal cortical cysts (HP:0000803) | 2.01561410 |
105 | Medulloblastoma (HP:0002885) | 2.00158506 |
106 | Testicular atrophy (HP:0000029) | 1.99183948 |
107 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.97991528 |
108 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.97991528 |
109 | Sloping forehead (HP:0000340) | 1.97863069 |
110 | Azoospermia (HP:0000027) | 1.97750426 |
111 | Embryonal renal neoplasm (HP:0011794) | 1.97716182 |
112 | Abnormality of the pons (HP:0007361) | 1.97230001 |
113 | Mitochondrial inheritance (HP:0001427) | 1.97173650 |
114 | Tracheoesophageal fistula (HP:0002575) | 1.95951951 |
115 | Short thumb (HP:0009778) | 1.95829807 |
116 | True hermaphroditism (HP:0010459) | 1.95470438 |
117 | Cellular immunodeficiency (HP:0005374) | 1.95044163 |
118 | Lymphoma (HP:0002665) | 1.94405969 |
119 | Degeneration of anterior horn cells (HP:0002398) | 1.93171658 |
120 | Abnormality of the anterior horn cell (HP:0006802) | 1.93171658 |
121 | Emotional lability (HP:0000712) | 1.92291728 |
122 | Supernumerary spleens (HP:0009799) | 1.91689898 |
123 | Stomach cancer (HP:0012126) | 1.91594822 |
124 | Megaloblastic anemia (HP:0001889) | 1.90861487 |
125 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.90844394 |
126 | Dicarboxylic aciduria (HP:0003215) | 1.90844394 |
127 | Microvesicular hepatic steatosis (HP:0001414) | 1.88855702 |
128 | Hyperglycinemia (HP:0002154) | 1.88534616 |
129 | Facial cleft (HP:0002006) | 1.86692032 |
130 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.85471580 |
131 | Preaxial hand polydactyly (HP:0001177) | 1.84984737 |
132 | IgM deficiency (HP:0002850) | 1.84967824 |
133 | Patchy hypopigmentation of hair (HP:0011365) | 1.84421256 |
134 | Hypoplasia of the pons (HP:0012110) | 1.83186402 |
135 | Sensory axonal neuropathy (HP:0003390) | 1.83181402 |
136 | Hepatocellular necrosis (HP:0001404) | 1.81521158 |
137 | Hepatic necrosis (HP:0002605) | 1.81149319 |
138 | Conical tooth (HP:0000698) | 1.80812482 |
139 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.77769703 |
140 | Congenital, generalized hypertrichosis (HP:0004540) | 1.77264444 |
141 | Abnormality of renal resorption (HP:0011038) | 1.77087709 |
142 | Hypergonadotropic hypogonadism (HP:0000815) | 1.76661755 |
143 | Premature ovarian failure (HP:0008209) | 1.75820033 |
144 | Cleft eyelid (HP:0000625) | 1.75573381 |
145 | Opisthotonus (HP:0002179) | 1.72882986 |
146 | Blindness (HP:0000618) | 1.71756771 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STK16 | 4.40207133 |
2 | VRK2 | 4.30992020 |
3 | BUB1 | 3.84991869 |
4 | NME2 | 3.73815836 |
5 | EIF2AK1 | 3.56447088 |
6 | WEE1 | 3.54465567 |
7 | MST4 | 3.24501467 |
8 | SRPK1 | 3.13529954 |
9 | MKNK1 | 3.02745270 |
10 | VRK1 | 2.82341761 |
11 | NEK1 | 2.77288262 |
12 | CDC7 | 2.67886031 |
13 | PLK4 | 2.52672371 |
14 | EIF2AK3 | 2.38851273 |
15 | ZAK | 2.21288519 |
16 | IRAK4 | 2.20989830 |
17 | MKNK2 | 2.13342970 |
18 | IRAK3 | 1.84109577 |
19 | TTK | 1.82669612 |
20 | TRIM28 | 1.74621497 |
21 | EIF2AK2 | 1.67160558 |
22 | TLK1 | 1.63287019 |
23 | PLK1 | 1.62588107 |
24 | CDK7 | 1.60012920 |
25 | BRSK2 | 1.53508357 |
26 | ATR | 1.51981570 |
27 | BMPR1B | 1.51583002 |
28 | PDK2 | 1.51055077 |
29 | PLK3 | 1.50348148 |
30 | CDK8 | 1.33534060 |
31 | CHEK2 | 1.33115701 |
32 | AKT3 | 1.30139622 |
33 | SCYL2 | 1.28756982 |
34 | NEK2 | 1.28294992 |
35 | MAP4K2 | 1.26984581 |
36 | MAP3K12 | 1.26187592 |
37 | TSSK6 | 1.25691157 |
38 | AURKB | 1.25007724 |
39 | ACVR1B | 1.21958078 |
40 | MUSK | 1.21375162 |
41 | PBK | 1.15349779 |
42 | BRAF | 1.15176930 |
43 | WNK3 | 1.12089394 |
44 | PIM2 | 1.07218044 |
45 | TAF1 | 1.05841549 |
46 | DYRK3 | 1.05548861 |
47 | DYRK2 | 1.01325509 |
48 | EPHA2 | 0.98563458 |
49 | NME1 | 0.94095666 |
50 | PAK4 | 0.93180148 |
51 | CHEK1 | 0.93101151 |
52 | AURKA | 0.92813003 |
53 | TXK | 0.91885060 |
54 | BRSK1 | 0.90385866 |
55 | MAPKAPK5 | 0.89324616 |
56 | STK38L | 0.88076836 |
57 | RPS6KA5 | 0.87270273 |
58 | CDK4 | 0.85900084 |
59 | NEK6 | 0.85847879 |
60 | DAPK1 | 0.85063371 |
61 | MAPK13 | 0.83085697 |
62 | CCNB1 | 0.81190818 |
63 | PASK | 0.79334367 |
64 | CDK3 | 0.78517401 |
65 | CSNK1G3 | 0.77836784 |
66 | SIK3 | 0.77057390 |
67 | YES1 | 0.76248626 |
68 | TEC | 0.75683191 |
69 | TAOK2 | 0.74994459 |
70 | CLK1 | 0.74726200 |
71 | CSNK2A1 | 0.73730414 |
72 | PINK1 | 0.73641996 |
73 | CDK12 | 0.73398275 |
74 | ATM | 0.73038481 |
75 | ADRBK2 | 0.72090534 |
76 | CSNK1G1 | 0.72031354 |
77 | PRKCI | 0.70875998 |
78 | TAOK3 | 0.69011808 |
79 | STK4 | 0.67263710 |
80 | RPS6KA4 | 0.67071282 |
81 | CSNK2A2 | 0.66085820 |
82 | CSNK1A1L | 0.63919874 |
83 | CDK2 | 0.62379192 |
84 | RPS6KB2 | 0.60751649 |
85 | CDK19 | 0.60680678 |
86 | ERBB4 | 0.59057313 |
87 | PLK2 | 0.58834144 |
88 | CASK | 0.57731536 |
89 | PIM1 | 0.56279213 |
90 | CSNK1G2 | 0.54236486 |
91 | OXSR1 | 0.53750644 |
92 | CDK1 | 0.52492065 |
93 | MAP3K8 | 0.51332722 |
94 | MAP3K6 | 0.51014761 |
95 | TGFBR1 | 0.50716823 |
96 | MAP2K3 | 0.50243532 |
97 | TNIK | 0.49997311 |
98 | ERBB3 | 0.49453180 |
99 | ALK | 0.47392478 |
100 | BCR | 0.46503570 |
101 | MAP2K6 | 0.43799988 |
102 | TNK2 | 0.42075159 |
103 | TIE1 | 0.41194387 |
104 | MYLK | 0.40914732 |
105 | NUAK1 | 0.38633271 |
106 | STK39 | 0.37748652 |
107 | LIMK1 | 0.37565341 |
108 | FLT3 | 0.35848253 |
109 | NLK | 0.34436250 |
110 | GRK1 | 0.32722220 |
111 | IRAK2 | 0.31465230 |
112 | IRAK1 | 0.31429341 |
113 | LYN | 0.30623243 |
114 | TGFBR2 | 0.30419746 |
115 | ILK | 0.30320713 |
116 | TESK1 | 0.30213811 |
117 | BMPR2 | 0.29787384 |
118 | INSRR | 0.29211871 |
119 | KIT | 0.28465834 |
120 | BRD4 | 0.28424513 |
121 | MAP3K3 | 0.27413595 |
122 | TESK2 | 0.27257474 |
123 | ABL2 | 0.27049907 |
124 | ARAF | 0.26908772 |
125 | MAPK14 | 0.26282231 |
126 | BCKDK | 0.25822710 |
127 | STK10 | 0.25457340 |
128 | KDR | 0.25121258 |
129 | IKBKB | 0.24398835 |
130 | PAK1 | 0.24237850 |
131 | CSNK1E | 0.23327754 |
132 | PNCK | 0.22404975 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 4.54111877 |
2 | RNA polymerase_Homo sapiens_hsa03020 | 3.94494144 |
3 | Mismatch repair_Homo sapiens_hsa03430 | 3.91299724 |
4 | * Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.80650428 |
5 | Proteasome_Homo sapiens_hsa03050 | 3.65556539 |
6 | Ribosome_Homo sapiens_hsa03010 | 3.58845650 |
7 | Homologous recombination_Homo sapiens_hsa03440 | 3.42831042 |
8 | Spliceosome_Homo sapiens_hsa03040 | 3.13654457 |
9 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.86524444 |
10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.86027676 |
11 | Base excision repair_Homo sapiens_hsa03410 | 2.72501743 |
12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.71106012 |
13 | * RNA transport_Homo sapiens_hsa03013 | 2.66581615 |
14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.50068093 |
15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.30497941 |
16 | Cell cycle_Homo sapiens_hsa04110 | 2.18851804 |
17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.12883204 |
18 | RNA degradation_Homo sapiens_hsa03018 | 1.95994780 |
19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.83576527 |
20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.76197568 |
21 | Purine metabolism_Homo sapiens_hsa00230 | 1.73706810 |
22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.59462369 |
23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.50214612 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.42072457 |
25 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.37102928 |
26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.26418203 |
27 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.22174325 |
28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.15411787 |
29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.13964598 |
30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.13731338 |
31 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13264485 |
32 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.10374308 |
33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.10259209 |
34 | Protein export_Homo sapiens_hsa03060 | 1.07259155 |
35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.06660717 |
36 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.05290590 |
37 | Parkinsons disease_Homo sapiens_hsa05012 | 1.04889015 |
38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.03658101 |
39 | Huntingtons disease_Homo sapiens_hsa05016 | 1.02192500 |
40 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.01836308 |
41 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98126048 |
42 | Carbon metabolism_Homo sapiens_hsa01200 | 0.97410136 |
43 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.96620299 |
44 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.87584377 |
45 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.87209122 |
46 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.85067666 |
47 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.82108771 |
48 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.81646566 |
49 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.80707243 |
50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.80310467 |
51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.76099070 |
52 | Sulfur relay system_Homo sapiens_hsa04122 | 0.74216130 |
53 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.70717593 |
54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69051722 |
55 | Asthma_Homo sapiens_hsa05310 | 0.65923092 |
56 | Peroxisome_Homo sapiens_hsa04146 | 0.65192557 |
57 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.64263191 |
58 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.55796517 |
59 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.54066527 |
60 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.54050368 |
61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52009723 |
62 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.51160280 |
63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49538707 |
64 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.48493254 |
65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.46881961 |
66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.45621901 |
67 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.45225460 |
68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43738773 |
69 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.43156850 |
70 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42728207 |
71 | Alzheimers disease_Homo sapiens_hsa05010 | 0.42347884 |
72 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38745745 |
73 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.38519888 |
74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.37581769 |
75 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.37118494 |
76 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.36678630 |
77 | Measles_Homo sapiens_hsa05162 | 0.36582460 |
78 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.36580327 |
79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.36015402 |
80 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.35965434 |
81 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.35935858 |
82 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.34123872 |
83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34008119 |
84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.33762665 |
85 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.31639339 |
86 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.31350261 |
87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.30296054 |
88 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.28841086 |
89 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.28802491 |
90 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.28356342 |
91 | HTLV-I infection_Homo sapiens_hsa05166 | 0.27898486 |
92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27559802 |
93 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.27465921 |
94 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26653420 |
95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.26039862 |
96 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.24650354 |
97 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.24210981 |
98 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.23951448 |
99 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.23934578 |
100 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.23485050 |
101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.23206672 |
102 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.22682034 |
103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.22528821 |
104 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.21493196 |
105 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.21327114 |
106 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.21050830 |
107 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.20196854 |
108 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.20036206 |
109 | Influenza A_Homo sapiens_hsa05164 | 0.19608876 |
110 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.19426833 |
111 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.19340915 |
112 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.19333888 |
113 | Thyroid cancer_Homo sapiens_hsa05216 | 0.19169129 |
114 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.18280483 |
115 | Other glycan degradation_Homo sapiens_hsa00511 | 0.17988197 |
116 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.17923072 |
117 | Allograft rejection_Homo sapiens_hsa05330 | 0.17337709 |
118 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.16518130 |
119 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.16509992 |
120 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.15970077 |
121 | Phototransduction_Homo sapiens_hsa04744 | 0.15804890 |
122 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.15480810 |
123 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.14482971 |
124 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.12629910 |
125 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.12469433 |
126 | Alcoholism_Homo sapiens_hsa05034 | 0.12023951 |
127 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.11152451 |
128 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.10575334 |