RPRD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66572470
2synaptic vesicle maturation (GO:0016188)5.23798314
3nuclear pore complex assembly (GO:0051292)5.17861413
4locomotory exploration behavior (GO:0035641)5.15634522
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02294666
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95760848
7glutamate secretion (GO:0014047)4.94139399
8synaptic vesicle exocytosis (GO:0016079)4.93250108
9nuclear pore organization (GO:0006999)4.91233899
10vocalization behavior (GO:0071625)4.74170346
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62700963
12neuronal action potential propagation (GO:0019227)4.52569939
13regulation of synaptic vesicle exocytosis (GO:2000300)4.47757341
14regulation of glutamate receptor signaling pathway (GO:1900449)4.46386086
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.42894142
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.37819590
17neuron cell-cell adhesion (GO:0007158)4.16448466
18regulation of neuronal synaptic plasticity (GO:0048168)4.13160323
19synaptic transmission, glutamatergic (GO:0035249)4.11271591
20neurotransmitter secretion (GO:0007269)4.08697892
21protein localization to synapse (GO:0035418)4.03933593
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03593467
23neuron-neuron synaptic transmission (GO:0007270)4.02370824
24glutamate receptor signaling pathway (GO:0007215)3.99713284
25regulation of synaptic vesicle transport (GO:1902803)3.98297449
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96924399
27exploration behavior (GO:0035640)3.96898859
28paraxial mesoderm development (GO:0048339)3.94664278
29regulation of synapse structural plasticity (GO:0051823)3.91493548
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85268630
31DNA unwinding involved in DNA replication (GO:0006268)3.78217092
32dendritic spine morphogenesis (GO:0060997)3.76627356
33pore complex assembly (GO:0046931)3.70146020
34long-term memory (GO:0007616)3.67898709
35layer formation in cerebral cortex (GO:0021819)3.66733258
36mitotic sister chromatid cohesion (GO:0007064)3.59724806
37neuron recognition (GO:0008038)3.58813298
38gamma-aminobutyric acid transport (GO:0015812)3.57748051
39transmission of nerve impulse (GO:0019226)3.52447695
40positive regulation of synapse maturation (GO:0090129)3.52069031
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.50924674
42establishment of integrated proviral latency (GO:0075713)3.47189702
43neurotransmitter-gated ion channel clustering (GO:0072578)3.47046140
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46406349
45regulation of dendritic spine morphogenesis (GO:0061001)3.42504591
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41837065
47cellular potassium ion homeostasis (GO:0030007)3.40167813
48neurotransmitter transport (GO:0006836)3.39200549
49regulation of synaptic plasticity (GO:0048167)3.39094237
50proline transport (GO:0015824)3.35710492
51positive regulation of membrane potential (GO:0045838)3.33388043
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32379156
53axonal fasciculation (GO:0007413)3.32116030
54regulation of postsynaptic membrane potential (GO:0060078)3.30367615
55activation of protein kinase A activity (GO:0034199)3.29035085
56long-term synaptic potentiation (GO:0060291)3.27031188
57behavioral defense response (GO:0002209)3.25515291
58behavioral fear response (GO:0001662)3.25515291
59neuromuscular process controlling balance (GO:0050885)3.21650128
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19042133
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18932770
62cell communication by electrical coupling (GO:0010644)3.18209033
63neuromuscular process controlling posture (GO:0050884)3.18153666
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.17343109
65regulation of neurotransmitter levels (GO:0001505)3.16562236
66membrane depolarization during action potential (GO:0086010)3.15004075
67vesicle transport along microtubule (GO:0047496)3.14377251
68striatum development (GO:0021756)3.10311229
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09443007
70synaptic vesicle endocytosis (GO:0048488)3.08348431
71L-amino acid import (GO:0043092)3.08274282
72cerebellar Purkinje cell differentiation (GO:0021702)3.07405023
73protein complex localization (GO:0031503)3.05349884
74protein localization to chromosome, centromeric region (GO:0071459)3.03347415
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02800042
76auditory behavior (GO:0031223)3.02266563
77fear response (GO:0042596)3.02243512
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01479277
79presynaptic membrane assembly (GO:0097105)3.00892219
80pre-miRNA processing (GO:0031054)3.00696174
81sodium ion export (GO:0071436)3.00248375
82regulation of neurotransmitter secretion (GO:0046928)3.00209188
83membrane depolarization (GO:0051899)2.99677191
84neuronal ion channel clustering (GO:0045161)2.96531978
85regulation of translational fidelity (GO:0006450)2.96080766
86dendrite morphogenesis (GO:0048813)2.95028515
87protein localization to kinetochore (GO:0034501)2.93828925
88mitotic chromosome condensation (GO:0007076)2.93795507
89cerebellar granule cell differentiation (GO:0021707)2.92570281
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91940834
91prepulse inhibition (GO:0060134)2.91724748
92presynaptic membrane organization (GO:0097090)2.90650903
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89132249
94adult walking behavior (GO:0007628)2.87750156
95synaptic transmission (GO:0007268)2.86980566
96dendritic spine organization (GO:0097061)2.86300166
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.84921676
98regulation of vesicle fusion (GO:0031338)2.84135092
99neuromuscular process (GO:0050905)2.84093978
100learning (GO:0007612)2.83527417
101response to histamine (GO:0034776)2.83376437
102regulation of neurotransmitter transport (GO:0051588)2.83237860
103organelle transport along microtubule (GO:0072384)2.82590775
104regulation of centriole replication (GO:0046599)2.82421912
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82238848
106innervation (GO:0060384)2.82003949
107non-recombinational repair (GO:0000726)2.81302052
108double-strand break repair via nonhomologous end joining (GO:0006303)2.81302052
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80630473
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.80298203
111regulation of dendritic spine development (GO:0060998)2.80237989
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80105916
113regulation of synaptic transmission (GO:0050804)2.80048872
114positive regulation of dendritic spine development (GO:0060999)2.77201453
115membrane hyperpolarization (GO:0060081)2.76920045
116cell migration in hindbrain (GO:0021535)2.76733811
117synapse organization (GO:0050808)2.75495381
118sister chromatid segregation (GO:0000819)2.75061503
119cellular protein complex localization (GO:0034629)2.66138261
120peptidyl-arginine omega-N-methylation (GO:0035247)2.62336294
121L-serine metabolic process (GO:0006563)2.62241440
122histone arginine methylation (GO:0034969)2.61373906
123mitotic sister chromatid segregation (GO:0000070)2.60617273
124glutamine metabolic process (GO:0006541)2.60191607
125notochord development (GO:0030903)2.58881162
126IMP biosynthetic process (GO:0006188)2.57116215
127peptidyl-arginine methylation (GO:0018216)2.55307848
128peptidyl-arginine N-methylation (GO:0035246)2.55307848
129regulation of chromosome segregation (GO:0051983)2.53934209
130DNA replication initiation (GO:0006270)2.53908064
131IMP metabolic process (GO:0046040)2.52972877
132chromatin remodeling at centromere (GO:0031055)2.52584500
133DNA strand elongation involved in DNA replication (GO:0006271)2.52359017
134DNA topological change (GO:0006265)2.50926586
135negative regulation of chromosome segregation (GO:0051985)2.50877044
136spindle checkpoint (GO:0031577)2.50406880
137positive regulation of chromosome segregation (GO:0051984)2.50059172
138CENP-A containing nucleosome assembly (GO:0034080)2.49554026
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.49115667
140negative regulation of sister chromatid segregation (GO:0033046)2.49115667
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49115667
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49115667
143negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49115667
144ribosome assembly (GO:0042255)2.46782768
145mitotic spindle checkpoint (GO:0071174)2.46403253
146regulation of mitotic sister chromatid separation (GO:0010965)2.44205650
147regulation of mitotic sister chromatid segregation (GO:0033047)2.44205650
148regulation of sister chromatid segregation (GO:0033045)2.44205650
149DNA strand elongation (GO:0022616)2.43838095
150regulation of sister chromatid cohesion (GO:0007063)2.42616317
151regulation of DNA endoreduplication (GO:0032875)2.42475148
152ATP-dependent chromatin remodeling (GO:0043044)2.41986479
153mitotic nuclear envelope disassembly (GO:0007077)2.40819412
154regulation of coenzyme metabolic process (GO:0051196)2.40768628
155regulation of cofactor metabolic process (GO:0051193)2.40768628
156membrane disassembly (GO:0030397)2.39707059
157nuclear envelope disassembly (GO:0051081)2.39707059
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.37793177
159regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37793177
160mitotic spindle assembly checkpoint (GO:0007094)2.36231425
161spindle assembly checkpoint (GO:0071173)2.34881966
162mitotic metaphase plate congression (GO:0007080)2.33728466
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.33254551
164positive regulation of cell cycle checkpoint (GO:1901978)2.33163127
165protein localization to chromosome (GO:0034502)2.33002745
166heterochromatin organization (GO:0070828)2.32439314
167regulation of mitotic spindle organization (GO:0060236)2.31349819
168histone exchange (GO:0043486)2.31209432
169purine nucleobase biosynthetic process (GO:0009113)2.31116217
170regulation of centrosome cycle (GO:0046605)2.29090278
171regulation of helicase activity (GO:0051095)2.29040537
172DNA duplex unwinding (GO:0032508)2.28108294
173establishment of viral latency (GO:0019043)2.27046925
174regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.22202693
175DNA geometric change (GO:0032392)2.21877470
176DNA ligation (GO:0006266)2.21219659
177negative regulation of DNA recombination (GO:0045910)2.19835680
178regulation of centrosome duplication (GO:0010824)2.19591020
179NLS-bearing protein import into nucleus (GO:0006607)2.19529114
180apical protein localization (GO:0045176)2.19464786
181chromosome condensation (GO:0030261)2.16291645
182metaphase plate congression (GO:0051310)2.14670169
183DNA replication checkpoint (GO:0000076)2.14479823
184regulation of translational elongation (GO:0006448)2.14222837
185peptidyl-lysine dimethylation (GO:0018027)2.13561392
186DNA replication-independent nucleosome assembly (GO:0006336)2.12784075
187DNA replication-independent nucleosome organization (GO:0034724)2.12784075
188negative regulation of mRNA processing (GO:0050686)2.12456949
189protein-DNA complex disassembly (GO:0032986)2.12273424
190nucleosome disassembly (GO:0006337)2.12273424
191regulation of RNA export from nucleus (GO:0046831)2.11418978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00741696
2EZH2_22144423_ChIP-Seq_EOC_Human6.06766589
3GBX2_23144817_ChIP-Seq_PC3_Human3.52898174
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.23575166
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.23369131
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.19529685
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97433975
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94691208
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93536233
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89406298
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.88197791
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.76528303
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72034397
14REST_21632747_ChIP-Seq_MESCs_Mouse2.70283184
15AR_21909140_ChIP-Seq_LNCAP_Human2.67090151
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57241054
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57241054
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.42936737
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39961624
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39238881
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33623238
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28229616
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27302001
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.27193847
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25461588
26DROSHA_22980978_ChIP-Seq_HELA_Human2.24024513
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.13298759
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09126652
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07384677
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.03386604
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.01571576
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01141663
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00228116
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98065249
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96533404
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93946166
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91859365
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89170976
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88350935
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.87597856
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87218494
42TAF15_26573619_Chip-Seq_HEK293_Human1.84633239
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79871616
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79329454
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77140625
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76296776
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76103231
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74241032
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73909669
50SMAD4_21799915_ChIP-Seq_A2780_Human1.71311678
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70888455
52IGF1R_20145208_ChIP-Seq_DFB_Human1.69290460
53ZNF274_21170338_ChIP-Seq_K562_Hela1.68784225
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66799194
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66439683
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66352739
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66266958
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64192384
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61761550
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61068517
61AR_21572438_ChIP-Seq_LNCaP_Human1.57408162
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57247563
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57020432
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.54984998
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.54353887
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45562892
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45331014
68* FUS_26573619_Chip-Seq_HEK293_Human1.43407927
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40369301
70P300_19829295_ChIP-Seq_ESCs_Human1.40119165
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.40062311
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39997966
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39885345
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.39810148
75STAT3_23295773_ChIP-Seq_U87_Human1.39274483
76XRN2_22483619_ChIP-Seq_HELA_Human1.39200841
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37874125
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37790703
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37032873
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35873662
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34977878
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34039737
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32171678
84ELK1_19687146_ChIP-ChIP_HELA_Human1.32135816
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32036168
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31587845
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31066516
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.28642409
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.27912423
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27823890
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.25413660
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24983167
93TTF2_22483619_ChIP-Seq_HELA_Human1.24884381
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24680604
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23917372
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23722167
97AR_19668381_ChIP-Seq_PC3_Human1.23096698
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22666184
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.22598250
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22223846
101* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21976995
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21873674
103AR_25329375_ChIP-Seq_VCAP_Human1.21341828
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.21095754
105MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19102108
106EWS_26573619_Chip-Seq_HEK293_Human1.18728382
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17733141
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16973403
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.16806227
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16166962
111TCF4_23295773_ChIP-Seq_U87_Human1.15884164
112VDR_22108803_ChIP-Seq_LS180_Human1.14420448
113RNF2_27304074_Chip-Seq_NSC_Mouse1.13450447
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13193275
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12607934
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12156202
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.11729386
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11712991
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11638778
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11579141
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10826463
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.10658664
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10417890
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10398728
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10386487
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10134211
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09600288
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07871155
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07466963
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06761261
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06463249
132DCP1A_22483619_ChIP-Seq_HELA_Human1.05158383
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04732435
134E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04469654
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03975789
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03884979
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03575342
138SOX17_20123909_ChIP-Seq_XEN_Mouse1.02793789
139ARNT_22903824_ChIP-Seq_MCF-7_Human1.02501123
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02227530
141SMAD_19615063_ChIP-ChIP_OVARY_Human1.01211566
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00914883
143RUNX2_22187159_ChIP-Seq_PCA_Human1.00051681
144TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00043587
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99870260
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99479454
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97974447
148TP53_16413492_ChIP-PET_HCT116_Human0.96346909
149REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96176257
150CHD1_26751641_Chip-Seq_LNCaP_Human0.96029052
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.95899856
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95712943
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95528432
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94705483
155AHR_22903824_ChIP-Seq_MCF-7_Human0.94674643
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.94261151
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93894967
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93350872
159JUN_21703547_ChIP-Seq_K562_Human0.92861645
160SOX9_26525672_Chip-Seq_HEART_Mouse0.92757448
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.92365322
162KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91487154
163ER_23166858_ChIP-Seq_MCF-7_Human0.90263162
164EP300_21415370_ChIP-Seq_HL-1_Mouse0.89735382
165RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88816545
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88104680
167HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87958415
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87774203
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.87553297
170SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87185947
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86746894
172POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.86572688
173* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86471692
174FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86330069
175SMAD3_21741376_ChIP-Seq_HESCs_Human0.85681421
176SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85655143
177CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85523413
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85366193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.94402891
2MP0003880_abnormal_central_pattern4.67982468
3MP0003635_abnormal_synaptic_transmissio3.82821148
4MP0004270_analgesia3.46428617
5MP0009745_abnormal_behavioral_response3.11321507
6MP0002063_abnormal_learning/memory/cond3.04594006
7MP0002064_seizures2.96215386
8MP0009046_muscle_twitch2.82485265
9MP0002822_catalepsy2.75699190
10MP0001968_abnormal_touch/_nociception2.64075238
11MP0002572_abnormal_emotion/affect_behav2.58588564
12MP0002272_abnormal_nervous_system2.55272764
13MP0008057_abnormal_DNA_replication2.53115200
14MP0001486_abnormal_startle_reflex2.41252325
15MP0002734_abnormal_mechanical_nocicepti2.39595438
16MP0003890_abnormal_embryonic-extraembry2.37079121
17MP0010094_abnormal_chromosome_stability2.36270627
18MP0003111_abnormal_nucleus_morphology2.30557071
19MP0004957_abnormal_blastocyst_morpholog2.29367700
20MP0005423_abnormal_somatic_nervous2.20440431
21MP0009780_abnormal_chondrocyte_physiolo2.13964921
22MP0002736_abnormal_nociception_after2.09578691
23MP0003693_abnormal_embryo_hatching2.06827279
24MP0001440_abnormal_grooming_behavior2.02118423
25MP0002735_abnormal_chemical_nociception2.00532481
26MP0003941_abnormal_skin_development1.91061782
27MP0000778_abnormal_nervous_system1.89311101
28MP0002067_abnormal_sensory_capabilities1.88366364
29MP0001501_abnormal_sleep_pattern1.88327867
30MP0010352_gastrointestinal_tract_polyps1.87796295
31MP0008932_abnormal_embryonic_tissue1.84362845
32MP0003077_abnormal_cell_cycle1.79376051
33MP0002733_abnormal_thermal_nociception1.78814448
34MP0008058_abnormal_DNA_repair1.76951524
35MP0003122_maternal_imprinting1.76447533
36MP0001529_abnormal_vocalization1.74685252
37MP0001970_abnormal_pain_threshold1.74091079
38MP0010234_abnormal_vibrissa_follicle1.73608121
39MP0004885_abnormal_endolymph1.70736802
40MP0009672_abnormal_birth_weight1.65234491
41MP0004924_abnormal_behavior1.64982622
42MP0005386_behavior/neurological_phenoty1.64982622
43MP0006276_abnormal_autonomic_nervous1.61615001
44MP0002184_abnormal_innervation1.61579040
45MP0002009_preneoplasia1.61500267
46MP0008569_lethality_at_weaning1.60991101
47MP0003937_abnormal_limbs/digits/tail_de1.60356240
48MP0002909_abnormal_adrenal_gland1.60165260
49MP0003329_amyloid_beta_deposits1.57744553
50MP0004811_abnormal_neuron_physiology1.55259355
51MP0001730_embryonic_growth_arrest1.53937968
52MP0000955_abnormal_spinal_cord1.53852483
53MP0002557_abnormal_social/conspecific_i1.51639499
54MP0003787_abnormal_imprinting1.51465534
55MP0005646_abnormal_pituitary_gland1.50486856
56MP0003123_paternal_imprinting1.50043018
57MP0000537_abnormal_urethra_morphology1.47808108
58MP0001984_abnormal_olfaction1.43460984
59MP0002084_abnormal_developmental_patter1.43213373
60MP0002882_abnormal_neuron_morphology1.41199470
61MP0002697_abnormal_eye_size1.40907128
62MP0002066_abnormal_motor_capabilities/c1.38724783
63MP0001905_abnormal_dopamine_level1.36204418
64MP0001672_abnormal_embryogenesis/_devel1.33403399
65MP0005380_embryogenesis_phenotype1.33403399
66MP0004858_abnormal_nervous_system1.30378507
67MP0004145_abnormal_muscle_electrophysio1.30238934
68MP0003136_yellow_coat_color1.29283832
69MP0000350_abnormal_cell_proliferation1.29190129
70MP0001293_anophthalmia1.27698859
71MP0000566_synostosis1.26764496
72MP0002837_dystrophic_cardiac_calcinosis1.26542355
73MP0004197_abnormal_fetal_growth/weight/1.25640296
74MP0008007_abnormal_cellular_replicative1.25499841
75MP0000751_myopathy1.24523667
76MP0002085_abnormal_embryonic_tissue1.20908269
77MP0002152_abnormal_brain_morphology1.20137554
78MP0003984_embryonic_growth_retardation1.19116126
79MP0004215_abnormal_myocardial_fiber1.18532335
80MP0009697_abnormal_copulation1.17653661
81MP0001697_abnormal_embryo_size1.16492931
82MP0000579_abnormal_nail_morphology1.14748628
83MP0004142_abnormal_muscle_tone1.13629331
84MP0002088_abnormal_embryonic_growth/wei1.13593244
85MP0003567_abnormal_fetal_cardiomyocyte1.13274832
86MP0003879_abnormal_hair_cell1.13212832
87MP0009703_decreased_birth_body1.10866403
88MP0001485_abnormal_pinna_reflex1.07895068
89MP0003633_abnormal_nervous_system1.07425903
90MP0005171_absent_coat_pigmentation1.07274937
91MP0003119_abnormal_digestive_system1.06358874
92MP0003121_genomic_imprinting1.05022866
93MP0004085_abnormal_heartbeat1.03836841
94MP0003283_abnormal_digestive_organ1.03643410
95MP0008877_abnormal_DNA_methylation1.03435293
96MP0002233_abnormal_nose_morphology1.02636322
97MP0004233_abnormal_muscle_weight1.02500877
98MP0003631_nervous_system_phenotype1.01710244
99MP0001286_abnormal_eye_development1.01453832
100MP0003385_abnormal_body_wall1.00519699
101MP0004742_abnormal_vestibular_system1.00037995
102MP0005623_abnormal_meninges_morphology0.99893868
103MP0002080_prenatal_lethality0.99608178
104MP0001177_atelectasis0.98099863
105MP0001346_abnormal_lacrimal_gland0.97529370
106MP0001502_abnormal_circadian_rhythm0.97103474
107MP0003705_abnormal_hypodermis_morpholog0.97089644
108MP0002229_neurodegeneration0.96018341
109MP0000013_abnormal_adipose_tissue0.95979396
110MP0001661_extended_life_span0.95813067
111MP0000428_abnormal_craniofacial_morphol0.95808966
112MP0003221_abnormal_cardiomyocyte_apopto0.93683617
113MP0005248_abnormal_Harderian_gland0.91915845
114MP0002938_white_spotting0.90949030
115MP0003634_abnormal_glial_cell0.89108585
116MP0005645_abnormal_hypothalamus_physiol0.88633850
117MP0003632_abnormal_nervous_system0.88426558
118MP0003942_abnormal_urinary_system0.88178624
119MP0005551_abnormal_eye_electrophysiolog0.88029217
120MP0006035_abnormal_mitochondrial_morpho0.87961408
121MP0001188_hyperpigmentation0.87406442
122MP0002269_muscular_atrophy0.87143018
123MP0000920_abnormal_myelination0.86985519
124MP0001299_abnormal_eye_distance/0.86330293
125MP0002081_perinatal_lethality0.85912647
126MP0003718_maternal_effect0.85738386
127MP0000747_muscle_weakness0.85413048
128MP0003690_abnormal_glial_cell0.85319636
129MP0000569_abnormal_digit_pigmentation0.84880799
130MP0002092_abnormal_eye_morphology0.84417273
131MP0003115_abnormal_respiratory_system0.84249701
132MP0003137_abnormal_impulse_conducting0.83875995
133MP0006292_abnormal_olfactory_placode0.83630492
134MP0002086_abnormal_extraembryonic_tissu0.83016732
135MP0001963_abnormal_hearing_physiology0.82862347
136MP0003935_abnormal_craniofacial_develop0.82116477
137MP0002752_abnormal_somatic_nervous0.81783029
138MP0003861_abnormal_nervous_system0.81659542
139MP0004043_abnormal_pH_regulation0.81573964
140MP0003315_abnormal_perineum_morphology0.80794568
141MP0002160_abnormal_reproductive_system0.80527183
142MP0002069_abnormal_eating/drinking_beha0.79795934
143MP0003755_abnormal_palate_morphology0.79781060
144MP0006072_abnormal_retinal_apoptosis0.79440388
145MP0002877_abnormal_melanocyte_morpholog0.79436361
146MP0000631_abnormal_neuroendocrine_gland0.79366359
147MP0004036_abnormal_muscle_relaxation0.76676205
148MP0004484_altered_response_of0.73570839
149MP0000762_abnormal_tongue_morphology0.73057658
150MP0010307_abnormal_tumor_latency0.72958239
151MP0000647_abnormal_sebaceous_gland0.72740219
152MP0005499_abnormal_olfactory_system0.71327308
153MP0005394_taste/olfaction_phenotype0.71327308
154MP0003646_muscle_fatigue0.69418750
155MP0002653_abnormal_ependyma_morphology0.66602710
156MP0005620_abnormal_muscle_contractility0.62945539
157MP0005187_abnormal_penis_morphology0.59792801
158MP0001943_abnormal_respiration0.59670369
159MP0008874_decreased_physiological_sensi0.59272329
160MP0004084_abnormal_cardiac_muscle0.58065656
161MP0008872_abnormal_physiological_respon0.58045617
162MP0010769_abnormal_survival0.56488494
163MP0005535_abnormal_body_temperature0.55616102
164MP0002234_abnormal_pharynx_morphology0.55098568
165MP0010770_preweaning_lethality0.54988732

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.59677841
2Myokymia (HP:0002411)5.95534811
3Focal seizures (HP:0007359)5.23682074
4Visual hallucinations (HP:0002367)4.52168096
5Atonic seizures (HP:0010819)4.44863350
6Epileptic encephalopathy (HP:0200134)4.20924544
7Absence seizures (HP:0002121)3.91528981
8Dialeptic seizures (HP:0011146)3.75216821
9Febrile seizures (HP:0002373)3.62195131
10Progressive cerebellar ataxia (HP:0002073)3.55247789
11Action tremor (HP:0002345)3.52213935
12Generalized tonic-clonic seizures (HP:0002069)3.52040998
13Impaired vibration sensation in the lower limbs (HP:0002166)3.25304059
14Broad-based gait (HP:0002136)3.20645017
15Termporal pattern (HP:0011008)3.00488439
16Insidious onset (HP:0003587)3.00488439
17Dysmetria (HP:0001310)2.99962161
18Dysdiadochokinesis (HP:0002075)2.99414935
19Cortical dysplasia (HP:0002539)2.98244061
20Hepatoblastoma (HP:0002884)2.96426056
21Ankle clonus (HP:0011448)2.94420677
22Gaze-evoked nystagmus (HP:0000640)2.94257094
23Abnormality of the lower motor neuron (HP:0002366)2.83034621
24Poor eye contact (HP:0000817)2.82824333
25Supranuclear gaze palsy (HP:0000605)2.78226212
26Chromsome breakage (HP:0040012)2.72007785
27Hyperventilation (HP:0002883)2.69322945
28Depression (HP:0000716)2.67470869
29Urinary bladder sphincter dysfunction (HP:0002839)2.67228711
30Truncal ataxia (HP:0002078)2.65379477
31Medulloblastoma (HP:0002885)2.63082524
32Impaired social interactions (HP:0000735)2.60324772
33Abnormal social behavior (HP:0012433)2.60324772
34Amblyopia (HP:0000646)2.59849771
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59843938
36Excessive salivation (HP:0003781)2.58617793
37Drooling (HP:0002307)2.58617793
38Spastic gait (HP:0002064)2.58011881
39Abnormality of the corticospinal tract (HP:0002492)2.51176857
40Anxiety (HP:0000739)2.50545270
41Nephroblastoma (Wilms tumor) (HP:0002667)2.49662500
42Scanning speech (HP:0002168)2.45450194
43Urinary urgency (HP:0000012)2.44735596
44Megalencephaly (HP:0001355)2.38305776
45Papillary thyroid carcinoma (HP:0002895)2.37446995
46Increased nuchal translucency (HP:0010880)2.36794340
47Embryonal renal neoplasm (HP:0011794)2.36062968
48Postural instability (HP:0002172)2.34125807
49Epileptiform EEG discharges (HP:0011182)2.32815872
50Intention tremor (HP:0002080)2.32359419
51Hemiparesis (HP:0001269)2.30695416
52Abnormal eating behavior (HP:0100738)2.30060688
53Ventricular fibrillation (HP:0001663)2.29519200
54Exercise-induced muscle cramps (HP:0003710)2.29352618
55Pheochromocytoma (HP:0002666)2.26964127
56Colon cancer (HP:0003003)2.24617557
57Genetic anticipation (HP:0003743)2.24307501
58EEG with generalized epileptiform discharges (HP:0011198)2.20484861
59Impaired smooth pursuit (HP:0007772)2.19669306
60Cerebral inclusion bodies (HP:0100314)2.16742516
61Lower limb muscle weakness (HP:0007340)2.16476021
62Mutism (HP:0002300)2.15840716
63Hyperinsulinemic hypoglycemia (HP:0000825)2.15272192
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.12919403
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12919403
66Hypsarrhythmia (HP:0002521)2.12121176
67Bundle branch block (HP:0011710)2.11493399
68Progressive inability to walk (HP:0002505)2.10313342
69Papilledema (HP:0001085)2.04380096
70Absent speech (HP:0001344)2.03069523
71Abnormal lung lobation (HP:0002101)2.01662406
72Bradykinesia (HP:0002067)2.01101021
73Generalized myoclonic seizures (HP:0002123)2.01075003
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.99498454
75Limb dystonia (HP:0002451)1.99366887
76Abnormality of the labia minora (HP:0012880)1.99143678
77Abnormality of ocular smooth pursuit (HP:0000617)1.98656317
78Fetal akinesia sequence (HP:0001989)1.97668518
79Volvulus (HP:0002580)1.95653125
80Gait ataxia (HP:0002066)1.95532491
81Impaired vibratory sensation (HP:0002495)1.94532707
82Clonus (HP:0002169)1.94034802
83Neurofibrillary tangles (HP:0002185)1.93808099
84Neuroendocrine neoplasm (HP:0100634)1.92971297
85Overlapping toe (HP:0001845)1.92876317
86Embryonal neoplasm (HP:0002898)1.92680311
87Abnormality of the astrocytes (HP:0100707)1.89357385
88Astrocytoma (HP:0009592)1.89357385
89Stereotypic behavior (HP:0000733)1.89123343
90Resting tremor (HP:0002322)1.88914235
91Hypoglycemic seizures (HP:0002173)1.88571975
92Torticollis (HP:0000473)1.88553329
93Dysmetric saccades (HP:0000641)1.88261827
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87964605
95Incomplete penetrance (HP:0003829)1.84577819
96Vertebral arch anomaly (HP:0008438)1.82606988
97Diplopia (HP:0000651)1.82473185
98Abnormality of binocular vision (HP:0011514)1.82473185
99Hemiplegia (HP:0002301)1.80162169
100Annular pancreas (HP:0001734)1.79421090
101Pointed chin (HP:0000307)1.79270298
102Neuroblastic tumors (HP:0004376)1.78948783
103Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.78948783
104Neuroblastoma (HP:0003006)1.78948783
105Primitive neuroectodermal tumor (HP:0030065)1.78948783
106Ependymoma (HP:0002888)1.78706591
107Thyroid carcinoma (HP:0002890)1.78188369
108Shoulder girdle muscle weakness (HP:0003547)1.78157398
109Postural tremor (HP:0002174)1.77394221
110High anterior hairline (HP:0009890)1.77183785
111Blue irides (HP:0000635)1.77020665
112Insomnia (HP:0100785)1.76256330
113Absent eyebrow (HP:0002223)1.74961593
114Focal dystonia (HP:0004373)1.74062688
115Delusions (HP:0000746)1.72547171
116Spastic diplegia (HP:0001264)1.72527041
117Abnormality of salivation (HP:0100755)1.72451207
118Microglossia (HP:0000171)1.71936100
119Multiple enchondromatosis (HP:0005701)1.71449965
120Pancreatic islet-cell hyperplasia (HP:0004510)1.70868642
121Specific learning disability (HP:0001328)1.70428712
122Rhabdomyosarcoma (HP:0002859)1.70206016
123Cutaneous finger syndactyly (HP:0010554)1.70205538
124Glioma (HP:0009733)1.69586549
125Rapidly progressive (HP:0003678)1.68974806
126Cutaneous syndactyly (HP:0012725)1.68146289
127Abnormal EKG (HP:0003115)1.68095948
128Facial cleft (HP:0002006)1.67628540
129Peripheral hypomyelination (HP:0007182)1.67011760
130Protruding tongue (HP:0010808)1.66824871
131Status epilepticus (HP:0002133)1.66775685
132Gait imbalance (HP:0002141)1.66670279
133Sudden death (HP:0001699)1.66574082
134Neoplasm of the peripheral nervous system (HP:0100007)1.66320619
135Choanal stenosis (HP:0000452)1.66033564
136Thickened helices (HP:0000391)1.65399902
137Morphological abnormality of the pyramidal tract (HP:0002062)1.64155352
138Agitation (HP:0000713)1.64073529
139Abnormality of chromosome segregation (HP:0002916)1.63739917
140Subaortic stenosis (HP:0001682)1.63464253
141Abnormality of the left ventricular outflow tract (HP:0011103)1.63464253
142Omphalocele (HP:0001539)1.62095327
143Hyperthyroidism (HP:0000836)1.61986036
144Obsessive-compulsive behavior (HP:0000722)1.57233914
145Alacrima (HP:0000522)1.56637492
146Malignant neoplasm of the central nervous system (HP:0100836)1.55430135
147Neoplasm of the small intestine (HP:0100833)1.54579949
148Neuroectodermal neoplasm (HP:0030061)1.54550886
149Neuroepithelial neoplasm (HP:0030063)1.54550886
150Nervous tissue neoplasm (HP:0030060)1.54550886
151Hypoglycemic coma (HP:0001325)1.52902614
152Abnormality of chromosome stability (HP:0003220)1.51745146
153Rimmed vacuoles (HP:0003805)1.51675871
154Hammertoe (HP:0001765)1.49829208
155Malignant gastrointestinal tract tumors (HP:0006749)1.49038696
156Gastrointestinal carcinoma (HP:0002672)1.49038696
157Birth length less than 3rd percentile (HP:0003561)1.46447417
158Abnormality of endocrine pancreas physiology (HP:0012093)1.45111220
159Abnormality of the pancreatic islet cells (HP:0006476)1.45111220
160Asymmetry of the thorax (HP:0001555)1.44913523
161Neoplasm of the oral cavity (HP:0100649)1.44561442
162Abnormality of the metopic suture (HP:0005556)1.44227223
163Ankyloglossia (HP:0010296)1.43651722
164Progressive external ophthalmoplegia (HP:0000590)1.43410516
165Missing ribs (HP:0000921)1.42852623
166Abnormality of glycolysis (HP:0004366)1.42531799
167Microvesicular hepatic steatosis (HP:0001414)1.41816273
168Neoplasm of striated muscle (HP:0009728)1.41669330
169Transposition of the great arteries (HP:0001669)1.41269168
170Abnormal connection of the cardiac segments (HP:0011545)1.41269168
171Abnormal ventriculo-arterial connection (HP:0011563)1.41269168
172Meckel diverticulum (HP:0002245)1.40926153
173Aplasia involving bones of the upper limbs (HP:0009823)1.40721744
174Aplasia of the phalanges of the hand (HP:0009802)1.40721744
175Aplasia involving bones of the extremities (HP:0009825)1.40721744
176Biliary tract neoplasm (HP:0100574)1.39916406
177Split foot (HP:0001839)1.39138000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62038786
2EPHA44.39400387
3MAP3K93.68659826
4MAP3K43.21666730
5LATS12.81934566
6SRPK12.63205746
7CDC72.46939130
8MINK12.38834100
9KSR22.36904589
10TTK2.32269358
11MAP2K72.30402070
12TSSK62.29682464
13MARK12.16037450
14PAK62.11715200
15PRKD32.10538655
16EEF2K2.06474446
17DAPK22.01511385
18STK38L1.97642165
19PNCK1.95002766
20MAP2K41.91583019
21KSR11.78571289
22NTRK21.78227880
23PLK41.75989003
24PRPF4B1.74152444
25MKNK11.73536704
26ERBB31.72614173
27PBK1.70936133
28MAP3K121.65294220
29ARAF1.64350329
30NTRK11.58000258
31BRD41.56970111
32CDK121.52150849
33BUB11.49447665
34EIF2AK11.47263179
35CDK191.43359849
36PLK21.43071501
37CASK1.42818601
38TYRO31.42528794
39CDK51.41233070
40WEE11.38520403
41CAMKK11.36058858
42MKNK21.34221834
43TNIK1.34201749
44EIF2AK31.33311568
45TRIM281.32852474
46MAP3K101.29037170
47TAF11.27663325
48UHMK11.27067196
49LATS21.26512785
50DAPK11.26447077
51OXSR11.15271817
52MAP3K21.14626310
53STK381.13422839
54SGK4941.12472157
55SGK2231.12472157
56MAPK131.11936095
57PRKCG1.11589129
58MAP3K131.10264680
59AKT31.10220540
60PLK11.10180990
61CAMK1D1.08174118
62GRK51.07328542
63CSNK1G11.06357019
64CSNK1A1L1.06347688
65PHKG21.03917030
66PHKG11.03917030
67CAMK2A1.02538214
68CHEK21.00345971
69CDK140.98528689
70NEK10.98365757
71PAK30.97402306
72CAMK2B0.96840492
73CDK180.96551669
74CDK150.96249414
75RIPK40.95658939
76BRSK20.93909186
77FES0.93789411
78CSNK1G30.88648090
79STK30.88184161
80CDK60.86966133
81RPS6KA40.86411746
82CAMKK20.85722246
83ATR0.85301108
84LMTK20.84772184
85CDK11A0.83074898
86NEK20.82849869
87ATM0.82292399
88SGK20.82264036
89BCR0.81613370
90CHEK10.80775563
91RAF10.80245657
92STK110.80002660
93FGFR10.79934990
94STK390.77891876
95CSNK1G20.77023444
96ICK0.75553156
97PINK10.74571209
98ZAK0.74135732
99DYRK30.72925434
100OBSCN0.72013093
101ALK0.71680974
102BRAF0.70914272
103RET0.70493637
104CCNB10.69725900
105FGFR20.69724687
106WNK10.69267900
107AURKB0.69164807
108CAMK10.68742208
109CDK30.68735687
110SGK30.68238923
111SGK10.68027124
112CDK10.67779749
113CAMK2D0.65887693
114PRKCH0.63749539
115CDK20.63526754
116DYRK1A0.63136232
117AKT20.62843056
118YES10.60080572
119FER0.60037365
120MET0.59796010
121PTK2B0.59395475
122MAPK100.56641981
123PRKDC0.56023386
124EIF2AK20.55836857
125BRSK10.54990869
126TAOK10.54890523
127CDK70.54563243
128ERBB40.54270054
129NEK60.53805206
130CAMK2G0.53127283
131SCYL20.51923606
132DYRK20.51329573
133RPS6KA30.51217873
134SIK20.51004710
135PDPK10.50587663
136PRKCE0.48517672
137NME10.47998224
138RPS6KB20.47917486
139RPS6KB10.47496465
140PLK30.47048555
141PDK10.46547080
142CSNK1E0.45863663
143CDC42BPA0.45630382
144ROCK20.44872655
145FGR0.44478988
146WNK30.43938943
147MARK20.43308917
148CAMK1G0.43017662
149MAP3K10.42146221
150PDK30.40117248
151PDK40.40117248
152MAP2K10.34739508
153PDGFRA0.34485110
154DMPK0.33885069

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70737911
2Synaptic vesicle cycle_Homo sapiens_hsa047213.13206462
3GABAergic synapse_Homo sapiens_hsa047272.79493862
4Long-term potentiation_Homo sapiens_hsa047202.74522488
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68652239
6Circadian entrainment_Homo sapiens_hsa047132.65777430
7Glutamatergic synapse_Homo sapiens_hsa047242.59152200
8Olfactory transduction_Homo sapiens_hsa047402.58083699
9Amphetamine addiction_Homo sapiens_hsa050312.53377221
10Morphine addiction_Homo sapiens_hsa050322.45956348
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45898865
12Dopaminergic synapse_Homo sapiens_hsa047282.24469857
13Non-homologous end-joining_Homo sapiens_hsa034502.24444639
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12444821
15DNA replication_Homo sapiens_hsa030302.07493900
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02659807
17Mismatch repair_Homo sapiens_hsa034301.98375776
18Insulin secretion_Homo sapiens_hsa049111.96904217
19Cell cycle_Homo sapiens_hsa041101.93804160
20RNA transport_Homo sapiens_hsa030131.92346754
21Salivary secretion_Homo sapiens_hsa049701.86452811
22mRNA surveillance pathway_Homo sapiens_hsa030151.86249073
23Cholinergic synapse_Homo sapiens_hsa047251.82442781
24Long-term depression_Homo sapiens_hsa047301.81783111
25Cocaine addiction_Homo sapiens_hsa050301.76145073
26Taste transduction_Homo sapiens_hsa047421.75299634
27Gastric acid secretion_Homo sapiens_hsa049711.74769979
28Spliceosome_Homo sapiens_hsa030401.72546135
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72426477
30Serotonergic synapse_Homo sapiens_hsa047261.65233851
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64821745
32Oxytocin signaling pathway_Homo sapiens_hsa049211.62306871
33Renin secretion_Homo sapiens_hsa049241.57836465
34Biosynthesis of amino acids_Homo sapiens_hsa012301.53410374
35Calcium signaling pathway_Homo sapiens_hsa040201.52595495
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52506202
37Collecting duct acid secretion_Homo sapiens_hsa049661.52337475
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48703360
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47200924
40GnRH signaling pathway_Homo sapiens_hsa049121.47089043
41Pyruvate metabolism_Homo sapiens_hsa006201.44400193
42Gap junction_Homo sapiens_hsa045401.40355341
43Steroid biosynthesis_Homo sapiens_hsa001001.37124175
44Oocyte meiosis_Homo sapiens_hsa041141.35047882
45Nucleotide excision repair_Homo sapiens_hsa034201.34672485
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.34493606
47Cardiac muscle contraction_Homo sapiens_hsa042601.29653298
48Adherens junction_Homo sapiens_hsa045201.26933732
49cAMP signaling pathway_Homo sapiens_hsa040241.25472265
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24601132
51Propanoate metabolism_Homo sapiens_hsa006401.24140152
52Fanconi anemia pathway_Homo sapiens_hsa034601.23316221
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22067749
54Nitrogen metabolism_Homo sapiens_hsa009101.21814744
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19466828
56Carbon metabolism_Homo sapiens_hsa012001.16328432
57Hippo signaling pathway_Homo sapiens_hsa043901.16267960
58Type II diabetes mellitus_Homo sapiens_hsa049301.16135814
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14591038
60Basal transcription factors_Homo sapiens_hsa030221.14554004
61Axon guidance_Homo sapiens_hsa043601.14178943
62One carbon pool by folate_Homo sapiens_hsa006701.13927175
63Estrogen signaling pathway_Homo sapiens_hsa049151.13851313
64Thyroid cancer_Homo sapiens_hsa052161.10597632
65Melanogenesis_Homo sapiens_hsa049161.10086700
66Glioma_Homo sapiens_hsa052141.10007165
67Vibrio cholerae infection_Homo sapiens_hsa051101.09186063
68Dorso-ventral axis formation_Homo sapiens_hsa043201.08377808
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06715791
70Base excision repair_Homo sapiens_hsa034101.04676345
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04341007
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02214217
73ErbB signaling pathway_Homo sapiens_hsa040121.01513230
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01441643
75Lysine degradation_Homo sapiens_hsa003100.99934783
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99536123
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97865406
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.96837120
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93874490
80Fatty acid biosynthesis_Homo sapiens_hsa000610.92976576
81Dilated cardiomyopathy_Homo sapiens_hsa054140.91805430
82Homologous recombination_Homo sapiens_hsa034400.91450771
83Fatty acid metabolism_Homo sapiens_hsa012120.89415654
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87925008
85RNA degradation_Homo sapiens_hsa030180.85301490
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.84930893
87Selenocompound metabolism_Homo sapiens_hsa004500.84593618
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.84383031
89Arginine and proline metabolism_Homo sapiens_hsa003300.81895816
90Colorectal cancer_Homo sapiens_hsa052100.81004568
91AMPK signaling pathway_Homo sapiens_hsa041520.78796983
92Phototransduction_Homo sapiens_hsa047440.78016879
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77335056
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76893080
95Choline metabolism in cancer_Homo sapiens_hsa052310.73794537
96Pancreatic secretion_Homo sapiens_hsa049720.73305310
97Fatty acid elongation_Homo sapiens_hsa000620.72485116
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71588376
99Thyroid hormone synthesis_Homo sapiens_hsa049180.71274039
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70056482
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68171046
102MicroRNAs in cancer_Homo sapiens_hsa052060.67331832
103RNA polymerase_Homo sapiens_hsa030200.67284673
104Renal cell carcinoma_Homo sapiens_hsa052110.67200975
105mTOR signaling pathway_Homo sapiens_hsa041500.66681275
106Glucagon signaling pathway_Homo sapiens_hsa049220.66537528
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65879937
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65729923
109MAPK signaling pathway_Homo sapiens_hsa040100.65576215
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63225984
111Alcoholism_Homo sapiens_hsa050340.63221955
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61197609
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57877460
114Ras signaling pathway_Homo sapiens_hsa040140.57230531
115Alzheimers disease_Homo sapiens_hsa050100.57098949
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56046352
117Circadian rhythm_Homo sapiens_hsa047100.56014019
118Basal cell carcinoma_Homo sapiens_hsa052170.56006429
119Purine metabolism_Homo sapiens_hsa002300.54912645
120TGF-beta signaling pathway_Homo sapiens_hsa043500.54290163
121Prostate cancer_Homo sapiens_hsa052150.54123319
122Arginine biosynthesis_Homo sapiens_hsa002200.53914382
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53559430
124Wnt signaling pathway_Homo sapiens_hsa043100.53184726
125Vitamin B6 metabolism_Homo sapiens_hsa007500.52928259
126Protein export_Homo sapiens_hsa030600.52257278
127Oxidative phosphorylation_Homo sapiens_hsa001900.51641753
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51145525
129Rap1 signaling pathway_Homo sapiens_hsa040150.50997650
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50417393
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49696427
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49654133
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.48906398
134VEGF signaling pathway_Homo sapiens_hsa043700.48023278
135Endometrial cancer_Homo sapiens_hsa052130.46818156
136Non-small cell lung cancer_Homo sapiens_hsa052230.46613152
137Melanoma_Homo sapiens_hsa052180.45612968
138Tight junction_Homo sapiens_hsa045300.44415667
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44371974
140Butanoate metabolism_Homo sapiens_hsa006500.44132823
141Insulin signaling pathway_Homo sapiens_hsa049100.43737795
142Parkinsons disease_Homo sapiens_hsa050120.43702505
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.43680593
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42326871
145Type I diabetes mellitus_Homo sapiens_hsa049400.41637762
146Endocytosis_Homo sapiens_hsa041440.41589849
147Hedgehog signaling pathway_Homo sapiens_hsa043400.41188130
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40633356
149Prion diseases_Homo sapiens_hsa050200.40008176
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.39547953
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39151777
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38918916
153Ovarian steroidogenesis_Homo sapiens_hsa049130.34947742
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34552648
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32974476

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